# SSR1 Gene Review Notes

## 2026-05-30 - PROTEOSTASIS PN TRAP-complex positive-control pass

Full review is present and marked complete. The local review supports SSR1/TRAP-alpha as an ER membrane component of the translocon-associated protein complex, associated with Sec61 and ribosome-bound translocons during co-translational protein targeting/translocation. The review modifies broad or misleading `protein binding` and post-translational-translocation annotations toward `GO:0140597 protein localization to ribosome-translocon complex` and `GO:0006613 cotranslational protein targeting to membrane`. [file:human/SSR1/SSR1-ai-review.yaml; PMID:36697828]

PN curation conclusion: the PN placement under `ER proteostasis > Protein transport > TRAP complex component` is a strong positive control. Broad PN projection to `GO:0015031 protein transport` is entailed by the more specific local translocation annotations and should be treated as confirmatory rather than a novel gene-review change.