# SSR2 Gene Review Notes

## 2026-05-30 - PROTEOSTASIS PN TRAP-complex positive-control pass

Full review is present and marked complete. The local review supports SSR2/TRAP-beta as an ER membrane subunit of the TRAP complex that associates with Sec61 during co-translational protein translocation, especially for nascent chains with weak or suboptimal signal peptides. The review modifies the `GO:0031204 post-translational protein targeting to membrane, translocation` annotation toward `GO:0006613 cotranslational protein targeting to membrane`. [file:human/SSR2/SSR2-ai-review.yaml; PMID:7789174; PMID:36697828]

PN curation conclusion: the PN placement under `ER proteostasis > Protein transport > TRAP complex component` is a strong positive control. As with SSR1, broad protein-transport propagation is biologically compatible but should be read against the more specific cotranslational ER-translocon function already curated locally.