STAT3 (Signal transducer and activator of transcription 3) is a latent cytoplasmic transcription factor that is activated by tyrosine phosphorylation (Tyr705) in response to cytokines and growth factors. Upon phosphorylation by JAK kinases, STAT3 forms dimers via reciprocal SH2 domain-phosphotyrosine interactions, translocates to the nucleus, binds DNA via its DNA-binding domain at GAS (gamma-activated sequence) elements, and regulates transcription of target genes involved in cell proliferation, survival, differentiation, and immune responses. STAT3 is a central mediator of the JAK-STAT signaling pathway, particularly downstream of IL-6 family cytokines (IL-6, LIF, CNTF, IL-11). The protein contains an N-terminal domain, coiled-coil domain, DNA-binding domain, linker domain, SH2 domain, and C-terminal transactivation domain. Serine phosphorylation (Ser727) modulates transcriptional activity and contributes to non-canonical mitochondrial functions (mitoSTAT3). STAT3 plays critical roles in immune regulation, inflammation, embryonic development, and is frequently constitutively activated in various cancers where it promotes oncogenic programs. In neural development, STAT3 promotes gliogenesis and astrocyte differentiation. ISOFORM BIOLOGY - Alternative splicing produces STAT3alpha (P40763-1, 770 AA) and STAT3beta (P40763-2, 722 AA). STAT3beta lacks the C-terminal transactivation domain (TAD) and can act as a dominant-negative for some alpha-specific target genes, but also has distinct transcriptional activities. The alpha/beta ratio modulates cellular responses, with STAT3beta showing tumor-suppressive functions in some contexts.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: file:human/STAT3/STAT3-deep-research-falcon.md model: Edison Scientific Literature |
| GO:0006952 defense response | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Defense response is a pleiotropic effect of STAT3 activation in immune cells, not the core molecular function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0042127 regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Cell proliferation regulation is a downstream effect of STAT3 target gene expression (e.g., MYC, CCND1), not core function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: Core cis-regulatory DNA binding; STAT3 recognizes and binds to GAS (gamma-activated sequence) elements in target gene promoters [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0006357 regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: Core regulation of transcription by RNA polymerase II [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IBA GO_REF:0000033 | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0090575 RNA polymerase II transcription regulator complex | IBA GO_REF:0000033 | ACCEPT | Summary: RNA polymerase II transcription regulator complex; STAT3 functions as part of transcriptional regulatory complexes [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0033210 leptin-mediated signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Leptin signaling is one of many STAT3-activating pathways, not defining core function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0043434 response to peptide hormone | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Response to peptide hormone is context-specific [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Growth hormone signaling is one pathway activating STAT3, not the defining function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0001817 regulation of cytokine production | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Regulation of cytokine production [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0003677 DNA binding | IEA GO_REF:0000120 | ACCEPT | Summary: Core DNA binding activity essential for STAT3 transcription factor function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0003700 DNA-binding transcription factor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000002 | ACCEPT | Summary: Regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0006955 immune response | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Immune response is a pleiotropic downstream effect, not core STAT3 transcription factor function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Signal transduction is too broad; STAT3's specific function is JAK-STAT signaling and transcriptional regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0019221 cytokine-mediated signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000117 | ACCEPT | Summary: Positive regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0051240 positive regulation of multicellular organismal process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Positive regulation of multicellular organismal process is too broad, not specific to STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0090575 RNA polymerase II transcription regulator complex | IEA GO_REF:0000117 | ACCEPT | Summary: RNA polymerase II transcription regulator complex; STAT3 functions as part of transcriptional regulatory complexes [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005515 protein binding | IPI PMID:11536047 MEN2A-RET-induced cellular transformation by activation of S... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:11536047 MEN2A-RET-induced cellular transformation by activation of STAT3. |
| GO:0005515 protein binding | IPI PMID:11585385 Human leptin signaling in human peripheral blood mononuclear... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:11585385 Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. |
| GO:0005515 protein binding | IPI PMID:11940572 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent ma... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:11940572 2002 Apr 8. ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. |
| GO:0005515 protein binding | IPI PMID:11970898 PTP1B regulates leptin signal transduction in vivo. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:11970898 PTP1B regulates leptin signal transduction in vivo. |
| GO:0005515 protein binding | IPI PMID:14966128 Structural requirements for signal transducer and activator ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:14966128 2004 Feb 13. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. |
| GO:0005515 protein binding | IPI PMID:15286705 Implication of BRG1 and cdk9 in the STAT3-mediated activatio... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:15286705 Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene. |
| GO:0005515 protein binding | IPI PMID:15657067 Phosphotyrosine signaling networks in epidermal growth facto... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:15657067 Epub 2005 Jan 17. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. |
| GO:0005515 protein binding | IPI PMID:15764709 STAT3 regulates Nemo-like kinase by mediating its interactio... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:15764709 STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. |
| GO:0005515 protein binding | IPI PMID:15821101 Mechanism of protein tyrosine phosphatase 1B-mediated inhibi... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:15821101 Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16273093 A quantitative protein interaction network for the ErbB receptors using protein microarrays. |
| GO:0005515 protein binding | IPI PMID:16331268 Physical and functional interactions between Daxx and STAT3. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16331268 Physical and functional interactions between Daxx and STAT3. |
| GO:0005515 protein binding | IPI PMID:16364321 Physical and functional interactions between STAT3 and Kapos... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16364321 2005 Dec 6. Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA. |
| GO:0005515 protein binding | IPI PMID:18200042 Crif1 is a novel transcriptional coactivator of STAT3. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:18200042 Crif1 is a novel transcriptional coactivator of STAT3. |
| GO:0005515 protein binding | IPI PMID:18330356 Construction and characterization of a normalized yeast two-... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:18330356 Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection. |
| GO:0005515 protein binding | IPI PMID:19345327 Persistently activated Stat3 maintains constitutive NF-kappa... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:19345327 Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. |
| GO:0005515 protein binding | IPI PMID:19372587 ErbB2-mediated Src and signal transducer and activator of tr... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:19372587 ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. |
| GO:0005515 protein binding | IPI PMID:20133729 STAT3 is a substrate of SYK tyrosine kinase in B-lineage leu... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:20133729 STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. |
| GO:0005515 protein binding | IPI PMID:20871632 The role of the c-Jun N-terminal kinase 2-Ξ±-isoform in non-s... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:20871632 The role of the c-Jun N-terminal kinase 2-Ξ±-isoform in non-small cell lung carcinoma tumorigenesis. |
| GO:0005515 protein binding | IPI PMID:20876300 Progesterone receptor induces ErbB-2 nuclear translocation t... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:20876300 Sep 27. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. |
| GO:0005515 protein binding | IPI PMID:20929579 Epigenetic regulation of CpG promoter methylation in invasiv... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:20929579 Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells. |
| GO:0005515 protein binding | IPI PMID:21184768 Novel role of signal transducer and activator of transcripti... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:21184768 2010 Dec 22. Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:21516116 Next-generation sequencing to generate interactome datasets. |
| GO:0005515 protein binding | IPI PMID:21643014 The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian c... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:21643014 The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. |
| GO:0005515 protein binding | IPI PMID:21953450 A complex of nuclear factor I-X3 and STAT3 regulates astrocy... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:21953450 2011 Sep 27. A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:21988832 Toward an understanding of the protein interaction network of the human liver. |
| GO:0005515 protein binding | IPI PMID:23416296 ECHS1 interacts with STAT3 and negatively regulates STAT3 si... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:23416296 2013 Feb 14. ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling. |
| GO:0005515 protein binding | IPI PMID:23684459 Phosphorylation of EZH2 activates STAT3 signaling via STAT3 ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:23684459 2013 May 16. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. |
| GO:0005515 protein binding | IPI PMID:24135280 EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 a... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:24135280 EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:24189400 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. |
| GO:0005515 protein binding | IPI PMID:24396070 SH2B1Ξ² interacts with STAT3 and enhances fibroblast growth f... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:24396070 Jan 6. SH2B1Ξ² interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. |
| GO:0005515 protein binding | IPI PMID:25065853 Drug resistance via feedback activation of Stat3 in oncogene... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25065853 2014 Jul 24. Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25241761 Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. |
| GO:0005515 protein binding | IPI PMID:25402766 Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signal... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25402766 Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25416956 A proteome-scale map of the human interactome network. |
| GO:0005515 protein binding | IPI PMID:25417160 A noncanonical Frizzled2 pathway regulates epithelial-mesenc... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25417160 A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. |
| GO:0005515 protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25814554 Phospho-tyrosine dependent protein-protein interaction network. |
| GO:0005515 protein binding | IPI PMID:26966684 PIPINO: A Software Package to Facilitate the Identification ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:26966684 PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:29892012 Jun 11. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. |
| GO:0005515 protein binding | IPI PMID:30042492 STAT3 localizes to the ER, acting as a gatekeeper for ER-mit... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:30042492 Epub 2018 Jul 24. STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses. |
| GO:0005515 protein binding | IPI PMID:30413785 ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:30413785 ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:31515488 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:32296183 Apr 8. A reference map of the human binary protein interactome. |
| GO:0005515 protein binding | IPI PMID:32852592 Biochanin A impedes STAT3 activation by upregulating p38Ξ΄ MA... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:32852592 2020 Aug 27. Biochanin A impedes STAT3 activation by upregulating p38Ξ΄ MAPK phosphorylation in IL-6-stimulated macrophages. |
| GO:0005515 protein binding | IPI PMID:32911434 A functionally defined high-density NRF2 interactome reveals... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:32911434 Aug 20. A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:35140242 Human transcription factor protein interaction networks. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:35140242 Human transcription factor protein interaction networks. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. |
| GO:0005515 protein binding | IPI PMID:38844957 Integrin Ξ±VΞ²1-activated PYK2 promotes the progression of non... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:38844957 Integrin Ξ±VΞ²1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis. |
| GO:0005515 protein binding | IPI PMID:8662591 Differential activation of acute phase response factor/STAT3... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:8662591 Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. |
| GO:0005515 protein binding | IPI PMID:9864141 Identification of a novel Stat3 recruitment and activation m... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:9864141 Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. |
| GO:0042802 identical protein binding | IPI PMID:17676033 Dominant-negative mutations in the DNA-binding domain of STA... | ACCEPT | Summary: Experimental evidence (IPI) supports identical protein binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:17676033 Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. |
| GO:0042802 identical protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | ACCEPT | Summary: Experimental evidence (IPI) supports identical protein binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:21988832 Toward an understanding of the protein interaction network of the human liver. |
| GO:0042802 identical protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | ACCEPT | Summary: Experimental evidence (IPI) supports identical protein binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. |
| GO:0042802 identical protein binding | IPI PMID:7510216 Interferon activation of the transcription factor Stat91 inv... | ACCEPT | Summary: Experimental evidence (IPI) supports identical protein binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. |
| GO:0000785 chromatin | IEA GO_REF:0000107 | ACCEPT | Summary: Chromatin localization for gene regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0000976 transcription cis-regulatory region binding | IEA GO_REF:0000107 | ACCEPT | Summary: Core transcription cis-regulatory region binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IEA GO_REF:0000107 | ACCEPT | Summary: Core cis-regulatory DNA binding; STAT3 recognizes and binds to GAS (gamma-activated sequence) elements in target gene promoters [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IEA GO_REF:0000107 | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0001666 response to hypoxia | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to hypoxia is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0002317 plasma cell differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for plasma cell differentiation is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0002931 response to ischemia | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to ischemia is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0005667 transcription regulator complex | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for transcription regulator complex is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0005743 mitochondrial inner membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for mitochondrial inner membrane is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0005829 cytosol | IEA GO_REF:0000120 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005886 plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for plasma membrane is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0006953 acute-phase response | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for acute-phase response is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0006954 inflammatory response | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for inflammatory response is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of cell proliferation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Positive regulation of gene expression [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0010730 negative regulation of hydrogen peroxide biosynthetic process | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of hydrogen peroxide biosynthetic process is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0014069 postsynaptic density | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for postsynaptic density is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for protein kinase binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0030968 endoplasmic reticulum unfolded protein response | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for endoplasmic reticulum unfolded protein response is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0031730 CCR5 chemokine receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for CCR5 chemokine receptor binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0032355 response to estradiol | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to estradiol is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for protein-containing complex is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0033210 leptin-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Leptin signaling is one of many STAT3-activating pathways, not defining core function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0034097 response to cytokine | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to cytokine is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0035259 nuclear glucocorticoid receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for nuclear glucocorticoid receptor binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0042802 identical protein binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for identical protein binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0042803 protein homodimerization activity | IEA GO_REF:0000107 | ACCEPT | Summary: Homodimerization via SH2 domain-phosphotyrosine (pY705) interactions is essential for STAT3 activation and nuclear translocation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Specific protein interaction critical for STAT3 function |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of canonical NF-kappaB signal transduction is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0043124 negative regulation of canonical NF-kappaB signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of canonical NF-kappaB signal transduction is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0043434 response to peptide hormone | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Response to peptide hormone is context-specific [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for phosphatidylinositol 3-kinase/protein kinase B signal transduction is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0043524 negative regulation of neuron apoptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of neuron apoptotic process is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0043565 sequence-specific DNA binding | IEA GO_REF:0000120 | ACCEPT | Summary: IEA annotation for sequence-specific DNA binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0044321 response to leptin | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to leptin is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0045471 response to ethanol | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for response to ethanol is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0045747 positive regulation of Notch signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of Notch signaling pathway is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0045766 positive regulation of angiogenesis | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of angiogenesis is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0046902 regulation of mitochondrial membrane permeability | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for regulation of mitochondrial membrane permeability is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0046983 protein dimerization activity | IEA GO_REF:0000107 | ACCEPT | Summary: Heterodimerization activity with other STAT family members (e.g., STAT1, STAT5) documented [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Specific protein interaction critical for STAT3 function |
| GO:0048708 astrocyte differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: Astrocyte differentiation promoted by STAT3 signaling, key role in gliogenesis; STAT3 activation promotes astrocyte over neuron fate [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Well-established differentiation function, relevant to NEURON_DEVELOPMENT |
| GO:0050728 negative regulation of inflammatory response | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of inflammatory response is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0050804 modulation of chemical synaptic transmission | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for modulation of chemical synaptic transmission is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0051726 regulation of cell cycle | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for regulation of cell cycle is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0060019 radial glial cell differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for radial glial cell differentiation is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0060259 regulation of feeding behavior | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: STAT3 acts downstream of hypothalamic leptin/JAK signalling, but as a highly pleiotropic transcription factor its link to feeding behaviour is an electronically-inferred, distal organismal output rather than a core STAT3 function. Reason: Electronic (IEA/ISS) behavioural annotation on a pleiotropic transcription factor; distal to its core JAK-STAT signalling role; non-core. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Growth hormone signaling is one pathway activating STAT3, not the defining function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0072540 T-helper 17 cell lineage commitment | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: T-helper 17 cell lineage commitment [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0097009 energy homeostasis | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for energy homeostasis is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0097398 cellular response to interleukin-17 | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for cellular response to interleukin-17 is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0097696 cell surface receptor signaling pathway via STAT | IEA GO_REF:0000107 | ACCEPT | Summary: STAT cascade is the core signaling mechanism [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for Schaffer collateral - CA1 synapse is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for glutamatergic synapse is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0099527 postsynapse to nucleus signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for postsynapse to nucleus signaling pathway is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0106015 negative regulation of inflammatory response to wounding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of inflammatory response to wounding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0140297 DNA-binding transcription factor binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for DNA-binding transcription factor binding is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0140311 protein sequestering activity | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for protein sequestering activity is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:1900016 negative regulation of cytokine production involved in inflammatory response | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of cytokine production involved in inflammatory response is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:1900037 regulation of cellular response to hypoxia | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for regulation of cellular response to hypoxia is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of growth factor dependent skeletal muscle satellite cell proliferation is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:1902895 positive regulation of miRNA transcription | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of miRNA transcription is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:1905564 positive regulation of vascular endothelial cell proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of vascular endothelial cell proliferation is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:2001171 positive regulation of ATP biosynthetic process | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for positive regulation of ATP biosynthetic process is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:2001243 negative regulation of intrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA annotation for negative regulation of intrinsic apoptotic signaling pathway is consistent with STAT3 function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Consistent computational annotation |
| GO:0048861 leukemia inhibitory factor signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: Experimental evidence (IDA) supports leukemia inhibitory factor signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:11294841 2001 Apr 6. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:10500198 Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine... | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:10500198 Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:11294841 2001 Apr 6. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |
| GO:0070120 ciliary neurotrophic factor-mediated signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: Experimental evidence (IDA) supports ciliary neurotrophic factor-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:11294841 2001 Apr 6. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:11285233 The ciliary neurotrophic factor receptor alpha component ind... | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:11285233 The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. |
| GO:0019221 cytokine-mediated signaling pathway | IDA PMID:11294841 Signaling pathways recruited by the cardiotrophin-like cytok... | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:11294841 2001 Apr 6. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |
| GO:0043524 negative regulation of neuron apoptotic process | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for negative regulation of neuron apoptotic process based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0097696 cell surface receptor signaling pathway via STAT | ISS GO_REF:0000024 | ACCEPT | Summary: STAT cascade is the core signaling mechanism [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0072540 T-helper 17 cell lineage commitment | ISS PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required fo... | KEEP AS NON CORE | Summary: T-helper 17 cell lineage commitment [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:27893700 Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | NAS PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signal... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signalling. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | NAS PMID:24058793 STAT heterodimers in immunity: A mixed message or a unique s... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:24058793 STAT heterodimers in immunity: A mixed message or a unique signal? Delgoffe GM(1), Vignali DA. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | NAS PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signal... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:15864272 Mechanisms of type-I- and type-II-interferon-mediated signalling. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | NAS PMID:24058793 STAT heterodimers in immunity: A mixed message or a unique s... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:24058793 STAT heterodimers in immunity: A mixed message or a unique signal? Delgoffe GM(1), Vignali DA. |
| GO:0050729 positive regulation of inflammatory response | IDA PMID:23125416 CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expre... | ACCEPT | Summary: Experimental evidence (IDA) supports positive regulation of inflammatory response for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:23125416 2012 Nov 2. CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive GΞ±(14/16) signaling and IL-6 release. |
| GO:0005515 protein binding | IPI PMID:29743632 A double helical motif in OCIAD2 is essential for its locali... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:29743632 A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation. |
| GO:0010629 negative regulation of gene expression | IDA PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to ... | ACCEPT | Summary: Experimental evidence (IDA) supports negative regulation of gene expression for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. |
| GO:0090091 positive regulation of extracellular matrix disassembly | IGI PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to ... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of extracellular matrix disassembly for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. |
| GO:0005634 nucleus | IDA PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. |
| GO:0050766 positive regulation of phagocytosis | IDA PMID:27994074 Novel Resolvin D2 Receptor Axis in Infectious Inflammation. | ACCEPT | Summary: Experimental evidence (IDA) supports positive regulation of phagocytosis for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:27994074 2016 Dec 19. Novel Resolvin D2 Receptor Axis in Infectious Inflammation. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0005737 cytoplasm | IDA PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. |
| GO:0140311 protein sequestering activity | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for protein sequestering activity based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:1900016 negative regulation of cytokine production involved in inflammatory response | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for negative regulation of cytokine production involved in inflammatory response based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0043124 negative regulation of canonical NF-kappaB signal transduction | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for negative regulation of canonical NF-kappaB signal transduction based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0003723 RNA binding | IPI PMID:31507089 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... | ACCEPT | Summary: Experimental evidence (IPI) supports RNA binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:31507089 Sep 10. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IMP PMID:38404237 A novel gain-of-function STAT3 variant in infantile-onset di... | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:38404237 A novel gain-of-function STAT3 variant in infantile-onset diabetes associated with multiorgan autoimmunity. |
| GO:0032755 positive regulation of interleukin-6 production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Positive regulation of interleukin-6 production [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for positive regulation of canonical NF-kappaB signal transduction based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0106222 lncRNA binding | IDA PMID:24744378 The STAT3-binding long noncoding RNA lnc-DC controls human d... | ACCEPT | Summary: Experimental evidence (IDA) supports lncRNA binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:24744378 The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a ... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic a... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:18782771 The STAT3 NH2-terminal domain stabilizes enhanceosome assemb... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:18782771 2008 Sep 9. The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain. |
| GO:0005634 nucleus | IDA PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a ... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. |
| GO:0005634 nucleus | IDA PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic a... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. |
| GO:0005737 cytoplasm | IDA PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a ... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. |
| GO:0005737 cytoplasm | IDA PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic a... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. |
| GO:0042803 protein homodimerization activity | IDA PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a ... | ACCEPT | Summary: Homodimerization via SH2 domain-phosphotyrosine (pY705) interactions is essential for STAT3 activation and nuclear translocation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Specific protein interaction critical for STAT3 function Supporting Evidence: PMID:15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic a... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:16285960 STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112565 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112602 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112727 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433456 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470009 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1888198 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-380782 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-452515 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784006 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784323 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786095 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786124 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788571 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788582 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8848087 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8848124 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875816 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875817 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950269 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950441 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950485 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950518 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952749 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982163 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982165 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983059 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983371 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983378 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984014 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984021 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985929 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985988 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8986985 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987014 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987063 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987070 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987080 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987096 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987097 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987104 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987141 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987150 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987255 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987266 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006870 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9006873 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9009072 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670412 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670416 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672159 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672176 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9701524 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9701525 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9701529 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9712079 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9712085 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9835443 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9850958 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9851142 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0010575 positive regulation of vascular endothelial growth factor production | IMP PMID:25596740 miR-874 functions as a tumor suppressor by inhibiting angiog... | ACCEPT | Summary: Experimental evidence (IMP) supports positive regulation of vascular endothelial growth factor production for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IMP) Supporting Evidence: PMID:25596740 miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. |
| GO:0097696 cell surface receptor signaling pathway via STAT | IMP PMID:25596740 miR-874 functions as a tumor suppressor by inhibiting angiog... | ACCEPT | Summary: STAT cascade is the core signaling mechanism [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:25596740 miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. |
| GO:0030335 positive regulation of cell migration | IMP PMID:31638206 MicroRNAβ4500 suppresses tumor progression in nonβsmall cell... | UNDECIDED | Summary: Experimental evidence (IMP) supports positive regulation of cell migration for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Real but borderline core vs non-core. STAT3's core molecular function is signal-dependent DNA-binding transcription factor activity (JAK-STAT); cell migration is a downstream transcriptional consequence rather than an activity STAT3 itself performs, and STAT3 is not part of the cytoskeletal/ adhesion motility machinery. The IMP evidence (knockdown/overexpression migration phenotype) is the classic indirect "perturb gene -> phenotype" inference. Flagged by the ASSAY_TO_FUNCTION CELL_MIGRATION_INVASION readout class; given STAT3 is high-profile and the call is genuinely contested (oncogenic migration driver vs downstream consequence), deferred to expert review rather than unilaterally demoted (issue #1422; staged OpenScientist hypothesis job under STAT3-hypotheses/). The OpenScientist cited adjudication (29 refs, verified) converged on NON-CORE (retain, not remove). Verification of its citations independently found that the supporting reference PMID:31638206 is indexed by PubMed as a RETRACTED publication, and surfaced a genuine non-transcriptional STAT3-stathmin microtubule mechanism (PMID:16401721) that currently has no GO cytoskeletal annotation - both noted for the expert (issue #1422). Supporting Evidence: PMID:31638206 Oct 11. MicroRNAβ4500 suppresses tumor progression in nonβsmall cell lung cancer by regulating STAT3. file:human/STAT3/STAT3-hypotheses/readout-go-0030335/openscientist.md Verdict NON-CORE (over-annotated as core): cell migration is a real, well-documented downstream consequence of STAT3's core transcription factor activity (e.g. transcriptional induction of Twist1, MMPs) rather than evidence STAT3 is part of the migration machinery; bidirectional context-dependent effects (also GO:2001223) are the hallmark of a transcription factor. Retain but reclassify non-core. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:32929201 PD-L1-mediated gasdermin C expression switches apoptosis to ... | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:32929201 2020 Sep 14. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. |
| GO:0070878 primary miRNA binding | IPI PMID:31507089 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... | ACCEPT | Summary: Experimental evidence (IPI) supports primary miRNA binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:31507089 Sep 10. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. |
| GO:0140610 RNA sequestering activity | IDA PMID:31507089 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... | ACCEPT | Summary: Experimental evidence (IDA) supports RNA sequestering activity for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:31507089 Sep 10. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. |
| GO:0019221 cytokine-mediated signaling pathway | NAS PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress... | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:12743296 STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-... | ACCEPT | Summary: Experimental evidence (IDA) supports phosphatidylinositol 3-kinase/protein kinase B signal transduction for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. |
| GO:0106015 negative regulation of inflammatory response to wounding | IDA PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-... | ACCEPT | Summary: Experimental evidence (IDA) supports negative regulation of inflammatory response to wounding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:27830702 Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. |
| GO:0005634 nucleus | IC PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. |
| GO:0035723 interleukin-15-mediated signaling pathway | IDA PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and... | ACCEPT | Summary: Interleukin-10-mediated signaling pathway activates STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. |
| GO:0038110 interleukin-2-mediated signaling pathway | IDA PMID:7568005 Critical role of the interleukin 2 (IL-2) receptor gamma-cha... | ACCEPT | Summary: Experimental evidence (IDA) supports interleukin-2-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:7568005 Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0005634 nucleus | IC PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0030154 cell differentiation | IDA PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | ACCEPT | Summary: Cell differentiation is a well-established STAT3 function across multiple cell types [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Well-established differentiation function, relevant to NEURON_DEVELOPMENT Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0038154 interleukin-11-mediated signaling pathway | IDA PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor ... | ACCEPT | Summary: Experimental evidence (IDA) supports interleukin-11-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:28781374 IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway. |
| GO:0003700 DNA-binding transcription factor activity | IC PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. |
| GO:0005634 nucleus | IC PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. |
| GO:0140105 interleukin-10-mediated signaling pathway | IDA PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 ... | ACCEPT | Summary: Experimental evidence (IDA) supports interleukin-10-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 ... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. |
| GO:0005634 nucleus | IC PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is re... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |
| GO:0038113 interleukin-9-mediated signaling pathway | IDA PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 ... | ACCEPT | Summary: Experimental evidence (IDA) supports interleukin-9-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. |
| GO:0005634 nucleus | IDA PMID:7528668 Interleukin-2 induces tyrosine phosphorylation and nuclear t... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:7528668 Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes. |
| GO:0038155 interleukin-23-mediated signaling pathway | IDA PMID:12023369 A receptor for the heterodimeric cytokine IL-23 is composed ... | ACCEPT | Summary: Experimental evidence (IDA) supports interleukin-23-mediated signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:12023369 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IDA PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. |
| GO:0005634 nucleus | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Core transcription activator activity; activated STAT3 dimers drive transcription of target genes including MYC, CCND1, BCL-XL, VEGF [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0032731 positive regulation of interleukin-1 beta production | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of interleukin-1 beta production for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0032733 positive regulation of interleukin-10 production | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of interleukin-10 production for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0032757 positive regulation of interleukin-8 production | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of interleukin-8 production for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0032760 positive regulation of tumor necrosis factor production | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of tumor necrosis factor production for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:1900017 positive regulation of cytokine production involved in inflammatory response | IGI PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Sys... | ACCEPT | Summary: Experimental evidence (IGI) supports positive regulation of cytokine production involved in inflammatory response for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:31886314 miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA. |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:15664994 Signal transducers and activators of transcription 3 augment... | ACCEPT | Summary: Experimental evidence (IPI) supports DNA-binding transcription factor binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:15664994 2005 Jan 21. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:28467929 PPARΞ³ Links BMP2 and TGFΞ²1 Pathways in Vascular Smooth Muscl... | ACCEPT | Summary: Experimental evidence (IPI) supports RNA polymerase II-specific DNA-binding transcription factor binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:28467929 PPARΞ³ Links BMP2 and TGFΞ²1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism. |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IGI PMID:28467929 PPARΞ³ Links BMP2 and TGFΞ²1 Pathways in Vascular Smooth Muscl... | ACCEPT | Summary: Experimental evidence (IGI) supports transforming growth factor beta receptor signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IGI) Supporting Evidence: PMID:28467929 PPARΞ³ Links BMP2 and TGFΞ²1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107... | ACCEPT | Summary: Experimental evidence (IPI) supports RNA polymerase II-specific DNA-binding transcription factor binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. |
| GO:0005102 signaling receptor binding | IPI PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | ACCEPT | Summary: Experimental evidence (IPI) supports signaling receptor binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:31145836 Jun 23. Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts. |
| GO:0035591 signaling adaptor activity | IPI PMID:31145836 Physical proximity and functional cooperation of glycoprotei... | ACCEPT | Summary: Experimental evidence (IPI) supports signaling adaptor activity for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:31145836 Jun 23. Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701529 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701531 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701534 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701537 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701549 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701557 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9701565 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9850958 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851058 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851062 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851064 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851071 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851106 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851118 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851122 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:2000635 negative regulation of primary miRNA processing | IMP PMID:31507089 Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... | ACCEPT | Summary: Experimental evidence (IMP) supports negative regulation of primary miRNA processing for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IMP) Supporting Evidence: PMID:31507089 Sep 10. Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. |
| GO:0005515 protein binding | IPI PMID:31899195 Prohibitin 1 interacts with signal transducer and activator ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:31899195 Dec 31. Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. |
| GO:0005634 nucleus | IDA PMID:31899195 Prohibitin 1 interacts with signal transducer and activator ... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:31899195 Dec 31. Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. |
| GO:0005737 cytoplasm | IDA PMID:31899195 Prohibitin 1 interacts with signal transducer and activator ... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:31899195 Dec 31. Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. |
| GO:0072538 T-helper 17 type immune response | IDA PMID:31899195 Prohibitin 1 interacts with signal transducer and activator ... | ACCEPT | Summary: Experimental evidence (IDA) supports T-helper 17 type immune response for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:31899195 Dec 31. Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells. |
| GO:0000785 chromatin | ISA GO_REF:0000113 | ACCEPT | Summary: Chromatin localization for gene regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | ISA GO_REF:0000113 | ACCEPT | Summary: Core transcription factor activity for STAT3, canonical function of STAT family proteins [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0005667 transcription regulator complex | IDA PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107... | ACCEPT | Summary: Experimental evidence (IDA) supports transcription regulator complex for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:24429361 Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. |
| GO:0010507 negative regulation of autophagy | IDA PMID:26962683 IL10 inhibits starvation-induced autophagy in hypertrophic s... | ACCEPT | Summary: Experimental evidence (IDA) supports negative regulation of autophagy for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:26962683 IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IDA PMID:16835372 Interleukin-6 induces hepcidin expression through STAT3. | ACCEPT | Summary: Core transcription activator activity; activated STAT3 dimers drive transcription of target genes including MYC, CCND1, BCL-XL, VEGF [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:16835372 Jul 11. Interleukin-6 induces hepcidin expression through STAT3. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IMP PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | ACCEPT | Summary: Core transcription activator activity; activated STAT3 dimers drive transcription of target genes including MYC, CCND1, BCL-XL, VEGF [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:16946298 Aug 31. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:16835372 Interleukin-6 induces hepcidin expression through STAT3. | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:16835372 Jul 11. Interleukin-6 induces hepcidin expression through STAT3. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:16946298 Aug 31. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. |
| GO:0005634 nucleus | IDA PMID:17360477 Identification of STAT3 as a substrate of receptor protein t... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:17360477 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. |
| GO:0005634 nucleus | IDA PMID:24846175 Ξ²1,6 GlcNAc branches-modified PTPRT attenuates its activity ... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:24846175 eCollection 2014. Ξ²1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway. |
| GO:0005737 cytoplasm | IDA PMID:17360477 Identification of STAT3 as a substrate of receptor protein t... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:17360477 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. |
| GO:0019903 protein phosphatase binding | IPI PMID:17360477 Identification of STAT3 as a substrate of receptor protein t... | ACCEPT | Summary: Experimental evidence (IPI) supports protein phosphatase binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:17360477 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. |
| GO:0030335 positive regulation of cell migration | IMP PMID:24846175 Ξ²1,6 GlcNAc branches-modified PTPRT attenuates its activity ... | UNDECIDED | Summary: Experimental evidence (IMP) supports positive regulation of cell migration for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Real but borderline core vs non-core (companion IMP annotation to the GO:0030335 call on PMID:31638206). STAT3's core is signal-dependent DNA-binding TF activity; cell migration is a downstream transcriptional consequence, not in the motility machinery. Flagged by ASSAY_TO_FUNCTION (CELL_MIGRATION_INVASION); deferred to expert review rather than unilaterally demoted. See issue #1422. Supporting Evidence: PMID:24846175 eCollection 2014. Ξ²1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8983379 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8985981 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983373 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983374 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983379 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985966 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985981 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983078 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8984023 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987033 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987052 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987156 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987161 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987214 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987230 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987270 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8987052 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0045648 positive regulation of erythrocyte differentiation | IMP PMID:28283061 Functional Selectivity in Cytokine Signaling Revealed Throug... | KEEP AS NON CORE | Summary: Positive regulation of erythrocyte differentiation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:28283061 Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. |
| GO:1902895 positive regulation of miRNA transcription | IDA PMID:19390056 Interleukin-6 modulates the expression of the bone morphogen... | ACCEPT | Summary: Experimental evidence (IDA) supports positive regulation of miRNA transcription for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:19390056 Epub 2009 Apr 23. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. |
| GO:0005515 protein binding | IPI PMID:24172987 A small GTPaseβlike protein fragment of Mycoplasma promotes ... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:24172987 A small GTPaseβlike protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3. |
| GO:0005515 protein binding | IPI PMID:28065600 Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STA... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:28065600 2017 Jan 5. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. |
| GO:0005634 nucleus | IDA PMID:28065600 Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STA... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:28065600 2017 Jan 5. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. |
| GO:0006954 inflammatory response | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for inflammatory response based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0042803 protein homodimerization activity | ISS GO_REF:0000024 | ACCEPT | Summary: Homodimerization via SH2 domain-phosphotyrosine (pY705) interactions is essential for STAT3 activation and nuclear translocation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Specific protein interaction critical for STAT3 function |
| GO:0072540 T-helper 17 cell lineage commitment | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: T-helper 17 cell lineage commitment [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:27050391 Rac1 modulates the formation of primordial follicles by faci... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:27050391 Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. |
| GO:0010628 positive regulation of gene expression | IMP PMID:24255059 Inhibition of microRNA-92a prevents endothelial dysfunction ... | KEEP AS NON CORE | Summary: Positive regulation of gene expression [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:24255059 2013 Nov 19. Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. |
| GO:1902895 positive regulation of miRNA transcription | IDA PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to ... | ACCEPT | Summary: Experimental evidence (IDA) supports positive regulation of miRNA transcription for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. |
| GO:0010628 positive regulation of gene expression | IDA PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to ... | KEEP AS NON CORE | Summary: Positive regulation of gene expression [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:23820254 STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. |
| GO:0005515 protein binding | IPI PMID:25476455 Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STA... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:25476455 Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA PMID:19390056 Interleukin-6 modulates the expression of the bone morphogen... | ACCEPT | Summary: Core cis-regulatory DNA binding; STAT3 recognizes and binds to GAS (gamma-activated sequence) elements in target gene promoters [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:19390056 Epub 2009 Apr 23. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:19390056 Interleukin-6 modulates the expression of the bone morphogen... | ACCEPT | Summary: Positive regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:19390056 Epub 2009 Apr 23. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. |
| GO:0060259 regulation of feeding behavior | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: STAT3 acts downstream of hypothalamic leptin/JAK signalling, but as a highly pleiotropic transcription factor its link to feeding behaviour is an electronically-inferred, distal organismal output rather than a core STAT3 function. Reason: Electronic (IEA/ISS) behavioural annotation on a pleiotropic transcription factor; distal to its core JAK-STAT signalling role; non-core. |
| GO:0097009 energy homeostasis | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for energy homeostasis based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0006355 regulation of DNA-templated transcription | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0031490 chromatin DNA binding | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Experimental evidence (IDA) supports chromatin DNA binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0033210 leptin-mediated signaling pathway | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | KEEP AS NON CORE | Summary: Leptin signaling is one of many STAT3-activating pathways, not defining core function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0044320 cellular response to leptin stimulus | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Experimental evidence (IDA) supports cellular response to leptin stimulus for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0044321 response to leptin | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Experimental evidence (IDA) supports response to leptin for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0051726 regulation of cell cycle | IDA PMID:17344214 leptin-induced growth stimulation of breast cancer cells inv... | ACCEPT | Summary: Experimental evidence (IDA) supports regulation of cell cycle for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17344214 2007 Mar 7. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. |
| GO:0070102 interleukin-6-mediated signaling pathway | IMP PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:16946298 Aug 31. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. |
| GO:0090575 RNA polymerase II transcription regulator complex | IMP PMID:16946298 STAT3 mediates hepatic hepcidin expression and its inflammat... | ACCEPT | Summary: RNA polymerase II transcription regulator complex; STAT3 functions as part of transcriptional regulatory complexes [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:16946298 Aug 31. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. |
| GO:0090575 RNA polymerase II transcription regulator complex | IC PMID:16835372 Interleukin-6 induces hepcidin expression through STAT3. | ACCEPT | Summary: RNA polymerase II transcription regulator complex; STAT3 functions as part of transcriptional regulatory complexes [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:16835372 Jul 11. Interleukin-6 induces hepcidin expression through STAT3. |
| GO:0070102 interleukin-6-mediated signaling pathway | IMP PMID:16835372 Interleukin-6 induces hepcidin expression through STAT3. | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:16835372 Jul 11. Interleukin-6 induces hepcidin expression through STAT3. |
| GO:0000785 chromatin | IDA PMID:16835372 Interleukin-6 induces hepcidin expression through STAT3. | ACCEPT | Summary: Chromatin localization for gene regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:16835372 Jul 11. Interleukin-6 induces hepcidin expression through STAT3. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:19754877 Hsp105beta upregulates hsp70 gene expression through signal ... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:19754877 2009 Sep 15. Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112538 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112587 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1112604 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470010 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1470012 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784763 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784765 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6784791 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786072 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786097 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6786293 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788622 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788623 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6788628 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950724 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950733 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950780 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8950782 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952823 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8982162 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8985900 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8987236 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670417 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670426 | ACCEPT | Summary: Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0019903 protein phosphatase binding | IPI PMID:12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP r... | ACCEPT | Summary: Experimental evidence (IPI) supports protein phosphatase binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP r... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-1112587 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-1470012 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2895778 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6784763 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6786293 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6788623 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8848150 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8950724 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8950733 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9670426 | ACCEPT | Summary: Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005737 cytoplasm | IDA PMID:22783022 The Sin3a repressor complex is a master regulator of STAT tr... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:22783022 The Sin3a repressor complex is a master regulator of STAT transcriptional activity. |
| GO:0005634 nucleus | IDA PMID:22783022 The Sin3a repressor complex is a master regulator of STAT tr... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:22783022 The Sin3a repressor complex is a master regulator of STAT transcriptional activity. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:22783022 The Sin3a repressor complex is a master regulator of STAT tr... | ACCEPT | Summary: Experimental evidence (IPI) supports RNA polymerase II-specific DNA-binding transcription factor binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IPI) Supporting Evidence: PMID:22783022 The Sin3a repressor complex is a master regulator of STAT transcriptional activity. |
| GO:0005515 protein binding | IPI PMID:12867595 The cell death regulator GRIM-19 is an inhibitor of signal t... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:12867595 The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. |
| GO:0005515 protein binding | IPI PMID:20826784 Acetylation directs survivin nuclear localization to repress... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:20826784 2010 Sep 8. Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. |
| GO:0004879 nuclear receptor activity | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Experimental evidence (IDA) supports nuclear receptor activity for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0030522 intracellular receptor signaling pathway | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Experimental evidence (IDA) supports intracellular receptor signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0005515 protein binding | IPI PMID:15998644 JAK/STAT3 pathway is involved in survival of neurons in resp... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:15998644 2005 Jul 5. JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. |
| GO:0005515 protein binding | IPI PMID:16568091 Identification of STAT3 as a specific substrate of breast tu... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16568091 Mar 27. Identification of STAT3 as a specific substrate of breast tumor kinase. |
| GO:0005515 protein binding | IPI PMID:10688651 Etk, a Btk family tyrosine kinase, mediates cellular transfo... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:10688651 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. |
| GO:0045747 positive regulation of Notch signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for positive regulation of Notch signaling pathway based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0048708 astrocyte differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: Astrocyte differentiation promoted by STAT3 signaling, key role in gliogenesis; STAT3 activation promotes astrocyte over neuron fate [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Well-established differentiation function, relevant to NEURON_DEVELOPMENT |
| GO:0060019 radial glial cell differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for radial glial cell differentiation based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0000976 transcription cis-regulatory region binding | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Core transcription cis-regulatory region binding for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0005634 nucleus | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Positive regulation of transcription by RNA polymerase II is the canonical STAT3 output [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:17324931 Interleukin-6 transcriptionally regulates prohibitin express... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:17324931 2007 Feb 26. Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. |
| GO:0060396 growth hormone receptor signaling pathway | IDA PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormon... | ACCEPT | Summary: Experimental evidence (IDA) supports growth hormone receptor signaling pathway for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:10925297 Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. |
| GO:0005634 nucleus | IDA PMID:18234692 BART is essential for nuclear retention of STAT3. | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:18234692 BART is essential for nuclear retention of STAT3. |
| GO:0005737 cytoplasm | IDA PMID:18234692 BART is essential for nuclear retention of STAT3. | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:18234692 BART is essential for nuclear retention of STAT3. |
| GO:0006606 protein import into nucleus | IDA PMID:18234692 BART is essential for nuclear retention of STAT3. | ACCEPT | Summary: Experimental evidence (IDA) supports protein import into nucleus for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:18234692 BART is essential for nuclear retention of STAT3. |
| GO:0005515 protein binding | IPI PMID:18234692 BART is essential for nuclear retention of STAT3. | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:18234692 BART is essential for nuclear retention of STAT3. |
| GO:0001659 temperature homeostasis | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for temperature homeostasis based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0001754 eye photoreceptor cell differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for eye photoreceptor cell differentiation based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0003677 DNA binding | ISS GO_REF:0000024 | ACCEPT | Summary: Core DNA binding activity essential for STAT3 transcription factor function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor |
| GO:0005634 nucleus | ISS GO_REF:0000024 | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for plasma membrane based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0006357 regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: Core regulation of transcription by RNA polymerase II [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0019901 protein kinase binding | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for protein kinase binding based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0042593 glucose homeostasis | ISS GO_REF:0000024 | ACCEPT | Summary: ISS annotation for glucose homeostasis based on sequence/structure similarity is reasonable for conserved STAT family function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Annotation inferred from sequence/structural similarity |
| GO:0042755 eating behavior | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Eating-behaviour effects of STAT3 reflect its role in leptin-responsive hypothalamic transcription, a distal consequence of STAT3 signalling rather than a direct STAT3 function; evidence is ISS only. Reason: Electronic (ISS) behavioural annotation on a pleiotropic transcription factor; non-core. |
| GO:0045893 positive regulation of DNA-templated transcription | ISS GO_REF:0000024 | ACCEPT | Summary: Positive regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation |
| GO:0046983 protein dimerization activity | ISS GO_REF:0000024 | ACCEPT | Summary: Heterodimerization activity with other STAT family members (e.g., STAT1, STAT5) documented [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Specific protein interaction critical for STAT3 function |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Growth hormone signaling is one pathway activating STAT3, not the defining function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function |
| GO:0005515 protein binding | IPI PMID:16531398 Tid1 isoforms are mitochondrial DnaJ-like chaperones with un... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16531398 Epub 2006 Mar 10. Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate. |
| GO:0060397 growth hormone receptor signaling pathway via JAK-STAT | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | KEEP AS NON CORE | Summary: Growth hormone signaling is one pathway activating STAT3, not the defining function [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. |
| GO:0032355 response to estradiol | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | ACCEPT | Summary: Experimental evidence (IDA) supports response to estradiol for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. |
| GO:0032870 cellular response to hormone stimulus | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | ACCEPT | Summary: Experimental evidence (IDA) supports cellular response to hormone stimulus for STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Direct experimental evidence (IDA) Supporting Evidence: PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. |
| GO:0070102 interleukin-6-mediated signaling pathway | IDA PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK... | ACCEPT | Summary: Interleukin-6-mediated signaling pathway [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. |
| GO:0005634 nucleus | IDA PMID:12444102 Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and i... | ACCEPT | Summary: Nucleus localization upon activation is core to STAT3 function; activated dimers translocate to nucleus [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:12444102 Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. |
| GO:0005515 protein binding | IPI PMID:16306601 Respiratory syncytial virus-inducible BCL-3 expression antag... | REMOVE | Summary: Generic 'protein binding' (GO:0005515) is uninformative and should be removed per GO curation guidelines. STAT3 has specific protein interactions (SH2-mediated homodimerization GO:0042803, heterodimerization GO:0046983, kinase binding GO:0019904) that are better represented by more specific terms [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Uninformative generic term per curation guidelines Supporting Evidence: PMID:16306601 Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. |
| GO:0006355 regulation of DNA-templated transcription | IDA PMID:15664994 Signal transducers and activators of transcription 3 augment... | ACCEPT | Summary: Regulation of DNA-templated transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:15664994 2005 Jan 21. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | TAS PMID:15664994 Signal transducers and activators of transcription 3 augment... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:15664994 2005 Jan 21. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. |
| GO:0019221 cytokine-mediated signaling pathway | NAS PMID:15664994 Signal transducers and activators of transcription 3 augment... | ACCEPT | Summary: Cytokine-mediated signaling is a core STAT3 function; responds to IL-6 family cytokines, interferons, and others [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:15664994 2005 Jan 21. Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | TAS PMID:8675499 STAT3beta, a splice variant of transcription factor STAT3, i... | ACCEPT | Summary: Curated annotation (TAS) supports negative regulation of transcription by RNA polymerase II [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Curated annotation (TAS) Supporting Evidence: PMID:8675499 STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. |
| GO:0003700 DNA-binding transcription factor activity | TAS PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene facto... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. |
| GO:0003700 DNA-binding transcription factor activity | TAS PMID:8675499 STAT3beta, a splice variant of transcription factor STAT3, i... | ACCEPT | Summary: Core DNA-binding transcription factor activity; STAT3 binds DNA via its DNA-binding domain to regulate target gene transcription [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core molecular function of STAT3 as transcription factor Supporting Evidence: PMID:8675499 STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. |
| GO:0005737 cytoplasm | TAS PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene facto... | ACCEPT | Summary: Cytoplasm localization of latent STAT3 before activation; unphosphorylated STAT3 resides in cytoplasm [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Correct cellular localization for STAT3 Supporting Evidence: PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. |
| GO:0006357 regulation of transcription by RNA polymerase II | TAS PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene facto... | ACCEPT | Summary: Core regulation of transcription by RNA polymerase II [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. |
| GO:0007165 signal transduction | TAS PMID:10205054 Synergistic signaling in fetal brain by STAT3-Smad1 complex ... | KEEP AS NON CORE | Summary: Signal transduction is too broad; STAT3's specific function is JAK-STAT signaling and transcriptional regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:10205054 Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. |
| GO:0007165 signal transduction | TAS PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene facto... | KEEP AS NON CORE | Summary: Signal transduction is too broad; STAT3's specific function is JAK-STAT signaling and transcriptional regulation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Valid annotation but peripheral to core STAT3 transcription factor function Supporting Evidence: PMID:7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | TAS PMID:9670957 The chemokine monocyte chemotactic protein 1 triggers Janus ... | ACCEPT | Summary: Core JAK-STAT signaling pathway; STAT3 is phosphorylated by JAKs (JAK1/2/3, TYK2) in response to cytokine receptor activation [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Core biological process - JAK-STAT signaling and transcriptional regulation Supporting Evidence: PMID:9670957 The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. |
| GO:0007399 nervous system development | TAS PMID:10205054 Synergistic signaling in fetal brain by STAT3-Smad1 complex ... | ACCEPT | Summary: Curated annotation (TAS) supports nervous system development [file:human/STAT3/STAT3-deep-research-falcon.md] Reason: Curated annotation (TAS) Supporting Evidence: PMID:10205054 Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. |
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