TERT (Telomerase Reverse Transcriptase) is the catalytic protein subunit of telomerase, a ribonucleoprotein enzyme essential for telomere maintenance. TERT catalyzes the template-directed addition of TTAGGG repeats to the 3' ends of telomeres using RNA-directed DNA polymerase activity, with the telomerase RNA component (TERC) providing the template. The enzyme operates as part of the telomerase holoenzyme complex containing TERT, TERC, DKC1, NOP10, NHP2, GAR1, and WRAP53/TCAB1. TERT is essential for cellular immortalization and is reactivated in ~90% of cancers. Beyond telomere maintenance, TERT exhibits non-canonical functions including RNA-dependent RNA polymerase activity when complexed with RMRP RNA, modulation of Wnt signaling, mitochondrial DNA protection, and regulation of cellular senescence and apoptosis. Germline mutations in TERT cause dyskeratosis congenita, aplastic anemia, and pulmonary fibrosis due to defective telomere maintenance.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0003720 telomerase activity | IDA PMID:9398860 Reconstitution of human telomerase with the template RNA com... | ACCEPT | Summary: Core enzymatic activity of TERT. The defining molecular function - catalyzes addition of TTAGGG repeats to telomeres using the TERC RNA template. Supporting Evidence: PMID:9398860 in vitro transcription and translation of hTRT when co-synthesized or mixed with hTR reconstitutes telomerase activity file:human/TERT/TERT-deep-research-openai.md See deep research file for comprehensive analysis |
| GO:0003720 telomerase activity | IDA PMID:9443919 Reconstitution of human telomerase activity in vitro. | ACCEPT | Summary: Additional evidence for telomerase activity from independent reconstitution study. Supporting Evidence: PMID:9443919 only exogenous hTR and TP2 are required for telomerase activity in vitro |
| GO:0003720 telomerase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference supports telomerase activity. |
| GO:0003720 telomerase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Automated annotation supports telomerase activity. |
| GO:0003964 RNA-directed DNA polymerase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core molecular function - TERT is a reverse transcriptase that synthesizes DNA using RNA template. |
| GO:0070034 telomerase RNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: Essential for telomerase function - TERT binds to TERC which provides the template for telomere synthesis. |
| GO:0070034 telomerase RNA binding | IEA GO_REF:0000107 | ACCEPT | Summary: Ortholog transfer. |
| GO:0042162 telomeric DNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: TERT binds to telomeric DNA substrate for extension. |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: TERT requires metal ions (Mg2+) for catalysis, but this is generic. Reason: Required for catalysis but not specifically informative about function |
| GO:0003968 RNA-directed RNA polymerase activity | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Non-canonical function - TERT forms complex with RMRP RNA that exhibits RdRP activity. Reason: Non-canonical function when complexed with RMRP, not TERC Supporting Evidence: PMID:19701182 Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner |
| GO:0000333 telomerase catalytic core complex | IDA PMID:9398860 Reconstitution of human telomerase with the template RNA com... | ACCEPT | Summary: Core complex - TERT forms the catalytic core with TERC. Supporting Evidence: PMID:9398860 in vitro transcription and translation of hTRT when co-synthesized or mixed with hTR reconstitutes telomerase activity |
| GO:0000333 telomerase catalytic core complex | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference. |
| GO:0000333 telomerase catalytic core complex | IEA GO_REF:0000107 | ACCEPT | Summary: Ortholog transfer. |
| GO:0005697 telomerase holoenzyme complex | IDA PMID:29695869 Cryo-EM structure of substrate-bound human telomerase holoen... | ACCEPT | Summary: Complete holoenzyme complex containing TERT, TERC, DKC1, NOP10, NHP2, GAR1, and WRAP53/TCAB1. Supporting Evidence: PMID:29695869 Apr 25. Cryo-EM structure of substrate-bound human telomerase holoenzyme. |
| GO:1990572 TERT-RMRP complex | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Distinct complex from telomerase, TERT with RMRP RNA for RdRP activity. Reason: Non-canonical complex with RMRP Supporting Evidence: PMID:19701182 Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Primary localization. TERT shuttles between cytoplasm and nucleus. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: Primary nuclear localization is in nucleoplasm. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-163090 | ACCEPT | Summary: Reactome pathway annotation for telomere elongation. |
| GO:0005654 nucleoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: UniProt subcellular location. |
| GO:0005730 nucleolus | IEA GO_REF:0000044 | ACCEPT | Summary: TERT localizes to nucleolus for holoenzyme assembly. |
| GO:0000781 chromosome, telomeric region | IEA GO_REF:0000044 | ACCEPT | Summary: TERT is recruited to telomeres. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: TERT can be cytoplasmic under certain conditions. Reason: Condition-dependent localization |
| GO:0005739 mitochondrion | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: TERT has non-canonical function in mitochondria protecting mtDNA. Reason: Non-canonical localization for mtDNA protection |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:9443919 Reconstitution of human telomerase activity in vitro. | ACCEPT | Summary: Primary biological process - TERT maintains telomeres by adding TTAGGG repeats. Supporting Evidence: PMID:9443919 only exogenous hTR and TP2 are required for telomerase activity in vitro |
| GO:0007004 telomere maintenance via telomerase | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference. |
| GO:0030177 positive regulation of Wnt signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Non-canonical function - TERT modulates Wnt signaling. Reason: Non-canonical transcriptional regulatory function Supporting Evidence: PMID:19571879 The telomerase protein component TERT (telomerase reverse transcriptase) interacts with BRG1 (also called SMARCA4), a SWI/SNF-related chromatin remodelling protein, and activates Wnt-dependent reporters in cultured cells and in vivo |
| GO:0043066 negative regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TERT has anti-apoptotic effects via telomere maintenance. Reason: Secondary effect of telomere maintenance |
| GO:0000723 telomere maintenance | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Parent term of telomere maintenance via telomerase. More specific child term is preferred. Reason: More specific child term GO:0007004 (telomere maintenance via telomerase) is annotated |
| GO:0003677 DNA binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Generic term - more specific telomeric DNA binding is annotated for canonical function. Reason: More specific GO:0042162 (telomeric DNA binding) is preferred, but DNA binding is retained as non-core |
| GO:0016605 PML body | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: TERT localizes to PML bodies under certain conditions, interacts with PML-IV. Reason: Condition-dependent localization for regulation |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Too generic - more specific telomerase activity is annotated. Reason: More specific child term GO:0003720 (telomerase activity) is annotated |
| GO:0016779 nucleotidyltransferase activity | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Too generic - more specific telomerase activity is annotated. Reason: More specific child term GO:0003720 (telomerase activity) is annotated |
| GO:0034061 DNA polymerase activity | IEA GO_REF:0000116 | MARK AS OVER ANNOTATED | Summary: Generic term - TERT is specifically an RNA-directed DNA polymerase (reverse transcriptase). Reason: More specific GO:0003964 (RNA-directed DNA polymerase activity) is annotated |
| GO:1990904 ribonucleoprotein complex | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Too generic - more specific telomerase complex terms are annotated. Reason: More specific terms GO:0000333 and GO:0005697 are annotated |
| GO:0005515 protein binding | IPI PMID:15381700 Characterization of interactions between PinX1 and human tel... | MARK AS OVER ANNOTATED | Summary: Interaction with PinX1 - generic protein binding term is uninformative. Reason: Protein binding is too generic; the specific interaction with PinX1 is already captured Supporting Evidence: PMID:15381700 2004 Sep 20. Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. |
| GO:0005515 protein binding | IPI PMID:17237767 TPP1 is a homologue of ciliate TEBP-beta and interacts with ... | MARK AS OVER ANNOTATED | Summary: Interaction with TPP1 for telomerase recruitment - generic term is uninformative. Reason: Protein binding is too generic; TPP1 interaction is part of shelterin recruitment Supporting Evidence: PMID:17237767 TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. |
| GO:0005515 protein binding | IPI PMID:18358808 Identification of ATPases pontin and reptin as telomerase co... | MARK AS OVER ANNOTATED | Summary: Interaction with Pontin/Reptin AAA+ ATPases for holoenzyme assembly. Reason: Protein binding is too generic Supporting Evidence: PMID:18358808 Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. |
| GO:0005515 protein binding | IPI PMID:19567472 PML-IV functions as a negative regulator of telomerase by in... | MARK AS OVER ANNOTATED | Summary: Interaction with PML-IV for telomerase inhibition. Reason: Protein binding is too generic Supporting Evidence: PMID:19567472 Jun 30. PML-IV functions as a negative regulator of telomerase by interacting with TERT. |
| GO:0005515 protein binding | IPI PMID:19571879 Telomerase modulates Wnt signalling by association with targ... | MARK AS OVER ANNOTATED | Summary: Interaction with BRG1 for Wnt signaling modulation. Reason: Protein binding is too generic; non-canonical Wnt function captured elsewhere Supporting Evidence: PMID:19571879 Telomerase modulates Wnt signalling by association with target gene chromatin. |
| GO:0005515 protein binding | IPI PMID:19843693 HPV E6 protein interacts physically and functionally with th... | MARK AS OVER ANNOTATED | Summary: Interaction with HPV E6 protein. Reason: Protein binding is too generic Supporting Evidence: PMID:19843693 HPV E6 protein interacts physically and functionally with the cellular telomerase complex. |
| GO:0005515 protein binding | IPI PMID:21829167 Human UPF1 interacts with TPP1 and telomerase and sustains t... | MARK AS OVER ANNOTATED | Summary: Interaction with UPF1 for telomere replication. Reason: Protein binding is too generic Supporting Evidence: PMID:21829167 Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. |
| GO:0005515 protein binding | IPI PMID:24550003 Involvement of telomerase reverse transcriptase in heterochr... | MARK AS OVER ANNOTATED | Summary: Interaction involved in heterochromatin maintenance. Reason: Protein binding is too generic Supporting Evidence: PMID:24550003 Feb 18. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. |
| GO:0005515 protein binding | IPI PMID:28255170 Nucleophosmin Interacts with PIN2/TERF1-interacting Telomera... | MARK AS OVER ANNOTATED | Summary: Interaction with nucleophosmin and PinX1. Reason: Protein binding is too generic Supporting Evidence: PMID:28255170 Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity. |
| GO:0042802 identical protein binding | IPI PMID:23474713 Structure of active dimeric human telomerase. | KEEP AS NON CORE | Summary: TERT forms functional dimers. Important for telomerase activity regulation. Reason: Dimerization is part of telomerase regulation Supporting Evidence: PMID:23474713 Mar 10. Structure of active dimeric human telomerase. |
| GO:0001223 transcription coactivator binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TERT binds BRG1 for Wnt signaling modulation - non-canonical function. Reason: Non-canonical function in gene regulation |
| GO:0003723 RNA binding | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Generic term - more specific telomerase RNA binding is annotated. Reason: More specific GO:0070034 (telomerase RNA binding) is annotated |
| GO:0005886 plasma membrane | IEA GO_REF:0000107 | REMOVE | Summary: Unlikely localization for TERT - nuclear/nucleolar protein. Reason: No strong evidence for plasma membrane localization |
| GO:0007507 heart development | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream pleiotropic effect, not core function. Reason: Downstream effect of telomere maintenance in cardiac progenitors |
| GO:0042635 positive regulation of hair cycle | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream pleiotropic effect in hair follicle stem cells. Reason: Downstream effect in stem cells, not core function |
| GO:0043524 negative regulation of neuron apoptotic process | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream anti-apoptotic effect. Reason: Downstream effect of telomere maintenance |
| GO:0045766 positive regulation of angiogenesis | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream pleiotropic effect in endothelial cells. Reason: Downstream effect of telomere maintenance in endothelial cells |
| GO:0046686 response to cadmium ion | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Stress response involving TERT - not core function. Reason: Indirect stress response |
| GO:0071456 cellular response to hypoxia | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TERT is regulated by and responds to hypoxia. Non-canonical function. Reason: TERT nuclear export under hypoxia is documented |
| GO:1900087 positive regulation of G1/S transition of mitotic cell cycle | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream effect of telomere maintenance enabling cell cycle progression. Reason: Downstream effect of telomere maintenance |
| GO:1903620 positive regulation of transdifferentiation | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream pleiotropic effect. Reason: Downstream effect, not core function |
| GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream effect in vascular smooth muscle cells. Reason: Downstream effect of telomere maintenance |
| GO:1904754 positive regulation of vascular associated smooth muscle cell migration | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Downstream effect in vascular smooth muscle cells. Reason: Downstream effect of telomere maintenance |
| GO:2000352 negative regulation of endothelial cell apoptotic process | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Anti-apoptotic effect in endothelial cells. Reason: Downstream effect of telomere maintenance |
| GO:2000648 positive regulation of stem cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TERT enables stem cell proliferation through telomere maintenance. Reason: Important for stem cell maintenance but downstream of core function |
| GO:0005829 cytosol | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: TERT can be cytoplasmic before nuclear import or under certain regulatory conditions. Reason: Transient localization before nuclear import |
| GO:0016607 nuclear speck | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: TERT may localize to nuclear speckles as part of nuclear organization. Reason: Secondary localization site |
| GO:0000722 telomere maintenance via recombination | NAS PMID:20351177 Specificity and stoichiometry of subunit interactions in the... | REMOVE | Summary: This is ALT pathway - TERT functions in telomerase-mediated maintenance, not recombination. Reason: TERT is not involved in recombination-based ALT; this is the alternative to telomerase Supporting Evidence: PMID:20351177 Mar 29. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. |
| GO:0007004 telomere maintenance via telomerase | NAS PMID:20351177 Specificity and stoichiometry of subunit interactions in the... | ACCEPT | Summary: Additional evidence for core telomerase function. Supporting Evidence: PMID:20351177 Mar 29. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. |
| GO:0030422 siRNA processing | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Non-canonical function via TERT-RMRP complex producing dsRNA processed by Dicer. Reason: Non-canonical RdRP function when complexed with RMRP Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0003723 RNA binding | IPI PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | MARK AS OVER ANNOTATED | Summary: RNA binding in context of RMRP interaction - more specific term preferred. Reason: More specific telomerase RNA binding is annotated Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0005515 protein binding | IPI PMID:25172512 The shelterin component TPP1 is a binding partner and substr... | MARK AS OVER ANNOTATED | Summary: Interaction with TPP1 and USP7. Reason: Protein binding is too generic Supporting Evidence: PMID:25172512 2014 Aug 29. The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7. |
| GO:0140745 siRNA transcription | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Non-canonical function via TERT-RMRP complex producing dsRNA precursors to siRNA. Reason: Non-canonical RdRP function when complexed with RMRP Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0006606 protein import into nucleus | IMP PMID:25999477 Akt-mediated phosphorylation increases the binding affinity ... | KEEP AS NON CORE | Summary: TERT nuclear import is regulated by Akt phosphorylation of Ser227. Reason: Regulatory process for TERT localization Supporting Evidence: PMID:25999477 May 21. Akt-mediated phosphorylation increases the binding affinity of hTERT for importin Ξ± to promote nuclear translocation. |
| GO:0005515 protein binding | IPI PMID:21846770 The DEAH-box RNA helicase RHAU binds an intramolecular RNA G... | MARK AS OVER ANNOTATED | Summary: Interaction with RHAU helicase. Reason: Protein binding is too generic Supporting Evidence: PMID:21846770 2011 Aug 16. The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. |
| GO:0003720 telomerase activity | IDA PMID:29695869 Cryo-EM structure of substrate-bound human telomerase holoen... | ACCEPT | Summary: Core function confirmed by cryo-EM structure of substrate-bound telomerase. Supporting Evidence: PMID:29695869 Apr 25. Cryo-EM structure of substrate-bound human telomerase holoenzyme. |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:29695869 Cryo-EM structure of substrate-bound human telomerase holoen... | ACCEPT | Summary: Core biological process confirmed by structural analysis. Supporting Evidence: PMID:29695869 Apr 25. Cryo-EM structure of substrate-bound human telomerase holoenzyme. |
| GO:0003720 telomerase activity | IDA PMID:16507993 Regulation of cellular immortalization and steady-state leve... | ACCEPT | Summary: Telomerase activity mediated by TERT C-terminal domain. Supporting Evidence: PMID:16507993 Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. |
| GO:0003720 telomerase activity | IDA PMID:17940095 Protein RNA and protein protein interactions mediate associa... | ACCEPT | Summary: Telomerase activity via EST1A/SMG6 interactions. Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0003720 telomerase activity | IDA PMID:18082603 Purification of human telomerase complexes identifies factor... | ACCEPT | Summary: Telomerase activity from purified holoenzyme complexes. Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0003720 telomerase activity | TAS PMID:23474713 Structure of active dimeric human telomerase. | ACCEPT | Summary: Telomerase activity in dimeric structure. Supporting Evidence: PMID:23474713 Mar 10. Structure of active dimeric human telomerase. |
| GO:0003720 telomerase activity | TAS PMID:23784080 HTLV-1 bZIP factor impedes the menin tumor suppressor and up... | ACCEPT | Summary: Telomerase activity in context of HTLV-1 regulation. Supporting Evidence: PMID:23784080 Jun 19. HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. |
| GO:0098680 template-free RNA nucleotidyltransferase activity | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Non-canonical RdRP function when complexed with RMRP. Reason: Non-canonical function with RMRP, not TERC Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0005515 protein binding | IPI PMID:11701125 The Pin2/TRF1-interacting protein PinX1 is a potent telomera... | MARK AS OVER ANNOTATED | Summary: Interaction with PinX1 telomerase inhibitor. Reason: Protein binding is too generic Supporting Evidence: PMID:11701125 The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. |
| GO:0003723 RNA binding | IPI PMID:16507993 Regulation of cellular immortalization and steady-state leve... | MARK AS OVER ANNOTATED | Summary: Generic term - telomerase RNA binding is more specific. Reason: More specific GO:0070034 (telomerase RNA binding) is annotated Supporting Evidence: PMID:16507993 Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. |
| GO:0003723 RNA binding | IPI PMID:17940095 Protein RNA and protein protein interactions mediate associa... | MARK AS OVER ANNOTATED | Summary: Generic term - telomerase RNA binding is more specific. Reason: More specific GO:0070034 (telomerase RNA binding) is annotated Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0003723 RNA binding | IPI PMID:18082603 Purification of human telomerase complexes identifies factor... | MARK AS OVER ANNOTATED | Summary: Generic term - telomerase RNA binding is more specific. Reason: More specific GO:0070034 (telomerase RNA binding) is annotated Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0003723 RNA binding | IPI PMID:20351177 Specificity and stoichiometry of subunit interactions in the... | MARK AS OVER ANNOTATED | Summary: Generic term - telomerase RNA binding is more specific. Reason: More specific GO:0070034 (telomerase RNA binding) is annotated Supporting Evidence: PMID:20351177 Mar 29. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. |
| GO:0003720 telomerase activity | TAS PMID:11927518 Endothelial cell senescence in human atherosclerosis: role o... | ACCEPT | Summary: Telomerase activity in endothelial senescence context. Supporting Evidence: PMID:11927518 Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. |
| GO:0003964 RNA-directed DNA polymerase activity | TAS PMID:25569094 Telomerase reverse transcriptase regulates microRNAs. | ACCEPT | Summary: Core reverse transcriptase activity of TERT. Supporting Evidence: PMID:25569094 Telomerase reverse transcriptase regulates microRNAs. |
| GO:0042635 positive regulation of hair cycle | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: Downstream pleiotropic effect from mouse orthologs. Reason: Downstream effect in stem cells |
| GO:2000648 positive regulation of stem cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Downstream effect of telomere maintenance in stem cells. Reason: Important for stem cell maintenance but downstream of core function |
| GO:0005515 protein binding | IPI PMID:22011238 The TPR-containing domain within Est1 homologs exhibits spec... | MARK AS OVER ANNOTATED | Summary: Interaction with EST1 homologs. Reason: Protein binding is too generic Supporting Evidence: PMID:22011238 The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. |
| GO:0005697 telomerase holoenzyme complex | TAS PMID:10757788 In vitro assembly of human H/ACA small nucleolar RNPs reveal... | ACCEPT | Summary: TERT is component of telomerase holoenzyme with H/ACA RNPs. Supporting Evidence: PMID:10757788 In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. |
| GO:0005697 telomerase holoenzyme complex | TAS PMID:22527283 An enhanced H/ACA RNP assembly mechanism for human telomeras... | ACCEPT | Summary: Enhanced H/ACA RNP assembly mechanism for telomerase. Supporting Evidence: PMID:22527283 Apr 23. An enhanced H/ACA RNP assembly mechanism for human telomerase RNA. |
| GO:0051087 protein-folding chaperone binding | IPI PMID:10197982 Functional requirement of p23 and Hsp90 in telomerase comple... | KEEP AS NON CORE | Summary: TERT requires p23 and Hsp90 for proper folding and assembly. Reason: Important for telomerase biogenesis Supporting Evidence: PMID:10197982 Functional requirement of p23 and Hsp90 in telomerase complexes. |
| GO:0051087 protein-folding chaperone binding | IPI PMID:19751963 Curcumin inhibits nuclear localization of telomerase by diss... | KEEP AS NON CORE | Summary: Curcumin dissociates Hsp90 co-chaperone p23 from TERT. Reason: Part of telomerase assembly regulation Supporting Evidence: PMID:19751963 2009 Sep 13. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. |
| GO:0042803 protein homodimerization activity | IPI PMID:23474713 Structure of active dimeric human telomerase. | KEEP AS NON CORE | Summary: TERT forms functional homodimers for telomerase activity. Reason: Important for telomerase regulation Supporting Evidence: PMID:23474713 Mar 10. Structure of active dimeric human telomerase. |
| GO:0000333 telomerase catalytic core complex | IDA PMID:9443919 Reconstitution of human telomerase activity in vitro. | ACCEPT | Summary: Core complex formation with TERC demonstrated by reconstitution. Supporting Evidence: PMID:9443919 Reconstitution of human telomerase activity in vitro. |
| GO:0000781 chromosome, telomeric region | IDA PMID:25589350 Single-strand DNA-binding protein SSB1 facilitates TERT recr... | ACCEPT | Summary: TERT is recruited to telomeres via SSB1 interaction. Supporting Evidence: PMID:25589350 2015 Jan 14. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. |
| GO:0005515 protein binding | IPI PMID:25589350 Single-strand DNA-binding protein SSB1 facilitates TERT recr... | MARK AS OVER ANNOTATED | Summary: Interaction with SSB1 for telomere recruitment. Reason: Protein binding is too generic Supporting Evidence: PMID:25589350 2015 Jan 14. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. |
| GO:0070200 establishment of protein localization to telomere | IDA PMID:25589350 Single-strand DNA-binding protein SSB1 facilitates TERT recr... | KEEP AS NON CORE | Summary: SSB1 facilitates TERT recruitment to telomeres. Reason: Part of telomerase recruitment mechanism Supporting Evidence: PMID:25589350 2015 Jan 14. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. |
| GO:0005634 nucleus | IDA PMID:21829167 Human UPF1 interacts with TPP1 and telomerase and sustains t... | ACCEPT | Summary: Nuclear localization for telomere maintenance. Supporting Evidence: PMID:21829167 Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. |
| GO:0005515 protein binding | IPI PMID:12377759 Human Ku70/80 associates physically with telomerase through ... | MARK AS OVER ANNOTATED | Summary: Interaction with Ku70/80 complex. Reason: Protein binding is too generic Supporting Evidence: PMID:12377759 2002 Oct 10. Human Ku70/80 associates physically with telomerase through interaction with hTERT. |
| GO:0070034 telomerase RNA binding | IPI PMID:17940095 Protein RNA and protein protein interactions mediate associa... | ACCEPT | Summary: TERT binds TERC RNA as essential component of telomerase. Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0000333 telomerase catalytic core complex | IDA PMID:17940095 Protein RNA and protein protein interactions mediate associa... | ACCEPT | Summary: Core complex with EST1A/SMG6 interactions. Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0000333 telomerase catalytic core complex | IPI PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | ACCEPT | Summary: Core complex component, distinct from RMRP complex. Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0005515 protein binding | IPI PMID:17940095 Protein RNA and protein protein interactions mediate associa... | MARK AS OVER ANNOTATED | Summary: Interaction with EST1A/SMG6. Reason: Protein binding is too generic Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:17940095 Protein RNA and protein protein interactions mediate associa... | ACCEPT | Summary: Core biological process of TERT. Supporting Evidence: PMID:17940095 Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. |
| GO:0000333 telomerase catalytic core complex | IDA PMID:16507993 Regulation of cellular immortalization and steady-state leve... | ACCEPT | Summary: C-terminal domain required for core complex function. Supporting Evidence: PMID:16507993 Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. |
| GO:0005515 protein binding | IPI PMID:19487455 GNL3L stabilizes the TRF1 complex and promotes mitotic trans... | MARK AS OVER ANNOTATED | Summary: Interaction with GNL3L. Reason: Protein binding is too generic Supporting Evidence: PMID:19487455 GNL3L stabilizes the TRF1 complex and promotes mitotic transition. |
| GO:0070034 telomerase RNA binding | IPI PMID:16507993 Regulation of cellular immortalization and steady-state leve... | ACCEPT | Summary: TERT C-terminal domain binds TERC. Supporting Evidence: PMID:16507993 Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. |
| GO:0000333 telomerase catalytic core complex | IDA PMID:18082603 Purification of human telomerase complexes identifies factor... | ACCEPT | Summary: Core complex from purified telomerase. Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0001172 RNA-templated transcription | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: Non-canonical RdRP function with RMRP RNA. Reason: Non-canonical function when complexed with RMRP Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0003964 RNA-directed DNA polymerase activity | IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip... | ACCEPT | Summary: TERT has RT activity in mitochondria independent of TERC - same core MF in a different cellular context. Supporting Evidence: PMID:21937513 Sep 21. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. |
| GO:0005697 telomerase holoenzyme complex | IDA PMID:18082603 Purification of human telomerase complexes identifies factor... | ACCEPT | Summary: TERT is core component of telomerase holoenzyme. Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0030177 positive regulation of Wnt signaling pathway | IGI PMID:19571879 Telomerase modulates Wnt signalling by association with targ... | KEEP AS NON CORE | Summary: Non-canonical function - TERT activates Wnt signaling via BRG1 interaction. Reason: Non-canonical transcriptional regulatory function Supporting Evidence: PMID:19571879 Telomerase modulates Wnt signalling by association with target gene chromatin. |
| GO:0031379 RNA-directed RNA polymerase complex | IPI PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | KEEP AS NON CORE | Summary: TERT-RMRP complex with RdRP activity. Reason: Non-canonical complex with RMRP, not TERC Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0070034 telomerase RNA binding | IPI PMID:18082603 Purification of human telomerase complexes identifies factor... | ACCEPT | Summary: Essential binding of TERT to TERC. Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0003720 telomerase activity | IDA PMID:21531765 High-throughput RNAi screening reveals novel regulators of t... | ACCEPT | Summary: RNAi screen identifying telomerase regulators. Supporting Evidence: PMID:21531765 High-throughput RNAi screening reveals novel regulators of telomerase. |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:21531765 High-throughput RNAi screening reveals novel regulators of t... | ACCEPT | Summary: Core biological process. Supporting Evidence: PMID:21531765 High-throughput RNAi screening reveals novel regulators of telomerase. |
| GO:0005515 protein binding | IPI PMID:21119197 Telomerase inhibitor PinX1 provides a link between TRF1 and ... | MARK AS OVER ANNOTATED | Summary: Interaction with PinX1/TRF1. Reason: Protein binding is too generic Supporting Evidence: PMID:21119197 2010 Nov 30. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. |
| GO:1904751 positive regulation of protein localization to nucleolus | IDA PMID:24415760 PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting... | KEEP AS NON CORE | Summary: TERT regulates PinX1 nucleolar localization. Reason: Regulatory function on PinX1 Supporting Evidence: PMID:24415760 2014 Jan 10. PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. |
| GO:0005515 protein binding | IPI PMID:18082603 Purification of human telomerase complexes identifies factor... | MARK AS OVER ANNOTATED | Summary: Interaction in telomerase holoenzyme. Reason: Protein binding is too generic Supporting Evidence: PMID:18082603 Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. |
| GO:0005515 protein binding | IPI PMID:15044100 Human MCRS2, a cell-cycle-dependent protein, associates with... | MARK AS OVER ANNOTATED | Summary: Interaction with MCRS2/PinX1. Reason: Protein binding is too generic Supporting Evidence: PMID:15044100 Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. |
| GO:0031647 regulation of protein stability | IDA PMID:26194824 Increased Stability of Nucleolar PinX1 in the Presence of TE... | KEEP AS NON CORE | Summary: TERT stabilizes nucleolar PinX1. Reason: Regulatory function on PinX1 Supporting Evidence: PMID:26194824 Jul 21. Increased Stability of Nucleolar PinX1 in the Presence of TERT. |
| GO:0031647 regulation of protein stability | IMP PMID:26194824 Increased Stability of Nucleolar PinX1 in the Presence of TE... | KEEP AS NON CORE | Summary: TERT stabilizes PinX1 protein. Reason: Regulatory function on PinX1 Supporting Evidence: PMID:26194824 Jul 21. Increased Stability of Nucleolar PinX1 in the Presence of TERT. |
| GO:0005634 nucleus | IDA PMID:24415760 PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting... | ACCEPT | Summary: Nuclear localization with PinX1. Supporting Evidence: PMID:24415760 2014 Jan 10. PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. |
| GO:0031647 regulation of protein stability | IDA PMID:24415760 PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting... | KEEP AS NON CORE | Summary: TERT modulates TRF1 homeostasis. Reason: Regulatory function Supporting Evidence: PMID:24415760 2014 Jan 10. PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. |
| GO:0005730 nucleolus | NAS PMID:26194824 Increased Stability of Nucleolar PinX1 in the Presence of TE... | ACCEPT | Summary: TERT localizes to nucleolus for holoenzyme assembly. Supporting Evidence: PMID:26194824 Jul 21. Increased Stability of Nucleolar PinX1 in the Presence of TERT. |
| GO:0070034 telomerase RNA binding | IPI PMID:20351177 Specificity and stoichiometry of subunit interactions in the... | ACCEPT | Summary: TERT-TERC binding specificity and stoichiometry. Supporting Evidence: PMID:20351177 Mar 29. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. |
| GO:0005515 protein binding | IPI PMID:22226966 The AAA-ATPase NVL2 is a telomerase component essential for ... | MARK AS OVER ANNOTATED | Summary: Interaction with NVL2 AAA-ATPase. Reason: Protein binding is too generic Supporting Evidence: PMID:22226966 The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. |
| GO:0005730 nucleolus | IDA PMID:22226966 The AAA-ATPase NVL2 is a telomerase component essential for ... | ACCEPT | Summary: Nucleolar localization for telomerase biogenesis. Supporting Evidence: PMID:22226966 The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. |
| GO:0005697 telomerase holoenzyme complex | IPI PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | ACCEPT | Summary: TERT component of holoenzyme (study also shows RMRP complex). Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | ACCEPT | Summary: Core biological process of TERT. Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0070034 telomerase RNA binding | IPI PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP ... | ACCEPT | Summary: TERT binds both TERC and RMRP RNAs. Supporting Evidence: PMID:19701182 An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. |
| GO:0000333 telomerase catalytic core complex | IMP PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cell... | ACCEPT | Summary: Core complex in hypoxia-induced telomerase activation. Supporting Evidence: PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. |
| GO:1902895 positive regulation of miRNA transcription | IMP PMID:25569094 Telomerase reverse transcriptase regulates microRNAs. | KEEP AS NON CORE | Summary: Non-canonical function - TERT regulates miRNA expression. Reason: Non-canonical gene regulatory function Supporting Evidence: PMID:25569094 Telomerase reverse transcriptase regulates microRNAs. |
| GO:0071456 cellular response to hypoxia | IMP PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cell... | KEEP AS NON CORE | Summary: TERT is induced by hypoxia, extends lifespan of vascular smooth muscle cells. Reason: Stress response function Supporting Evidence: PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. |
| GO:2000773 negative regulation of cellular senescence | IMP PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cell... | KEEP AS NON CORE | Summary: TERT prevents cellular senescence through telomere maintenance. Reason: Downstream consequence of telomere maintenance Supporting Evidence: PMID:11313459 Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. |
| GO:2000773 negative regulation of cellular senescence | IDA PMID:11927518 Endothelial cell senescence in human atherosclerosis: role o... | KEEP AS NON CORE | Summary: TERT prevents endothelial senescence. Reason: Downstream consequence of telomere maintenance Supporting Evidence: PMID:11927518 Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. |
| GO:0006278 RNA-templated DNA biosynthetic process | IDA PMID:9398860 Reconstitution of human telomerase with the template RNA com... | ACCEPT | Summary: Core function - TERT synthesizes DNA using RNA template. Supporting Evidence: PMID:9398860 Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. |
| GO:0007004 telomere maintenance via telomerase | IDA PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telome... | ACCEPT | Summary: POT1 disrupts G-quadruplexes allowing telomerase extension. Supporting Evidence: PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. |
| GO:0071897 DNA biosynthetic process | IDA PMID:9398860 Reconstitution of human telomerase with the template RNA com... | MARK AS OVER ANNOTATED | Summary: Generic term - more specific RNA-templated DNA biosynthesis is preferred. Reason: More specific GO:0006278 is annotated Supporting Evidence: PMID:9398860 Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. |
| GO:0007005 mitochondrion organization | IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip... | KEEP AS NON CORE | Summary: Non-canonical mitochondrial function of TERT. Reason: Non-canonical function in mitochondria Supporting Evidence: PMID:21937513 Sep 21. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. |
| GO:0000049 tRNA binding | IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip... | KEEP AS NON CORE | Summary: TERT binds mitochondrial tRNAs. Reason: Non-canonical mitochondrial function Supporting Evidence: PMID:21937513 Sep 21. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. |
| GO:0003677 DNA binding | IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip... | KEEP AS NON CORE | Summary: TERT binds mitochondrial DNA. Reason: Non-canonical mitochondrial DNA binding Supporting Evidence: PMID:21937513 Sep 21. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. |
| GO:0042645 mitochondrial nucleoid | IDA PMID:21937513 Human telomerase acts as a hTR-independent reverse transcrip... | KEEP AS NON CORE | Summary: TERT localizes to mitochondrial nucleoids. Reason: Non-canonical mitochondrial localization Supporting Evidence: PMID:21937513 Sep 21. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. |
| GO:0001223 transcription coactivator binding | IPI PMID:19571879 Telomerase modulates Wnt signalling by association with targ... | KEEP AS NON CORE | Summary: TERT binds BRG1 chromatin remodeler for Wnt signaling. Reason: Non-canonical transcriptional function Supporting Evidence: PMID:19571879 Telomerase modulates Wnt signalling by association with target gene chromatin. |
| GO:0007004 telomere maintenance via telomerase | NAS PMID:2805070 The human telomere terminal transferase enzyme is a ribonucl... | ACCEPT | Summary: Early foundational study on telomerase function. Supporting Evidence: PMID:2805070 The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. |
| GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP PMID:10449030 Resistance to apoptosis in human cells conferred by telomera... | KEEP AS NON CORE | Summary: TERT confers resistance to apoptosis via telomere stabilization. Reason: Downstream consequence of telomere maintenance Supporting Evidence: PMID:10449030 Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-163096 | ACCEPT | Summary: Nucleoplasm localization for telomerase RNP recruitment to telomeres. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-163099 | ACCEPT | Summary: Nucleoplasm localization for RNA template alignment. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-163120 | ACCEPT | Summary: Nucleoplasm localization for telomerase RNP disassociation. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-164616 | ACCEPT | Summary: Nucleoplasm localization for telomerase biogenesis. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-164617 | ACCEPT | Summary: Nucleoplasm localization for telomere elongation. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-164620 | ACCEPT | Summary: Nucleoplasm localization for template translocation. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3322422 | ACCEPT | Summary: Nucleoplasm localization for beta-catenin/SMARCA4 interaction. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9858734 | ACCEPT | Summary: Nucleoplasm localization for MITF-mediated TERT expression. |
| GO:0005515 protein binding | IPI PMID:19179534 A human telomerase holoenzyme protein required for Cajal bod... | MARK AS OVER ANNOTATED | Summary: Interaction with TCAB1 for Cajal body localization. Reason: Protein binding is too generic Supporting Evidence: PMID:19179534 A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. |
| GO:0005654 nucleoplasm | IDA PMID:19567472 PML-IV functions as a negative regulator of telomerase by in... | ACCEPT | Summary: Nucleoplasm localization with PML-IV interaction. Supporting Evidence: PMID:19567472 Jun 30. PML-IV functions as a negative regulator of telomerase by interacting with TERT. |
| GO:0016605 PML body | IDA PMID:19567472 PML-IV functions as a negative regulator of telomerase by in... | KEEP AS NON CORE | Summary: TERT localizes to PML bodies where PML-IV inhibits telomerase. Reason: Regulatory localization for telomerase inhibition Supporting Evidence: PMID:19567472 Jun 30. PML-IV functions as a negative regulator of telomerase by interacting with TERT. |
| GO:0090399 replicative senescence | IMP PMID:9454332 Extension of life-span by introduction of telomerase into no... | KEEP AS NON CORE | Summary: TERT expression extends lifespan and bypasses replicative senescence. Reason: Downstream consequence of telomere maintenance Supporting Evidence: PMID:9454332 Extension of life-span by introduction of telomerase into normal human cells. |
| GO:0000783 nuclear telomere cap complex | IC PMID:15632080 Human protection of telomeres 1 (POT1) is a negative regulat... | ACCEPT | Summary: TERT interaction with POT1 at telomere cap. Supporting Evidence: PMID:15632080 Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. |
| GO:0007004 telomere maintenance via telomerase | IMP PMID:9454332 Extension of life-span by introduction of telomerase into no... | ACCEPT | Summary: Landmark paper showing TERT extends cell lifespan via telomere maintenance. Supporting Evidence: PMID:9454332 Extension of life-span by introduction of telomerase into normal human cells. |
| GO:0042803 protein homodimerization activity | IDA PMID:11432839 Human telomerase contains two cooperating telomerase RNA mol... | KEEP AS NON CORE | Summary: Telomerase contains two cooperating TERT molecules. Reason: Dimerization mechanism Supporting Evidence: PMID:11432839 Human telomerase contains two cooperating telomerase RNA molecules. |
| GO:0070034 telomerase RNA binding | IDA PMID:11432839 Human telomerase contains two cooperating telomerase RNA mol... | ACCEPT | Summary: Two TERT molecules bind two TERC RNA molecules. Supporting Evidence: PMID:11432839 Human telomerase contains two cooperating telomerase RNA molecules. |
| GO:0003720 telomerase activity | IDA PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telome... | ACCEPT | Summary: Telomerase activity demonstrated with POT1 regulation. Supporting Evidence: PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. |
| GO:0022616 DNA strand elongation | IDA PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telome... | ACCEPT | Summary: TERT elongates telomeric DNA strand. Supporting Evidence: PMID:16043710 Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. |
| GO:0005515 protein binding | IPI PMID:12699629 Functional conservation of the telomerase protein Est1p in h... | MARK AS OVER ANNOTATED | Summary: Interaction with EST1 homologs. Reason: Protein binding is too generic Supporting Evidence: PMID:12699629 Functional conservation of the telomerase protein Est1p in humans. |
| GO:0000781 chromosome, telomeric region | IC PMID:12135483 Differential regulation of telomerase activity by six telome... | ACCEPT | Summary: TERT localizes to telomeres. Supporting Evidence: PMID:12135483 Differential regulation of telomerase activity by six telomerase subunits. |
| GO:0000723 telomere maintenance | TAS PMID:12135483 Differential regulation of telomerase activity by six telome... | MARK AS OVER ANNOTATED | Summary: Parent term - more specific telomere maintenance via telomerase preferred. Reason: More specific GO:0007004 is annotated Supporting Evidence: PMID:12135483 Differential regulation of telomerase activity by six telomerase subunits. |
| GO:0003720 telomerase activity | IDA PMID:12135483 Differential regulation of telomerase activity by six telome... | ACCEPT | Summary: Differential regulation by telomerase subunits. Supporting Evidence: PMID:12135483 Differential regulation of telomerase activity by six telomerase subunits. |
| GO:0003720 telomerase activity | TAS PMID:14991929 Modulation of human telomerase reverse transcriptase in hepa... | ACCEPT | Summary: Telomerase modulation in hepatocellular carcinoma. Supporting Evidence: PMID:14991929 Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma. |
| GO:0005697 telomerase holoenzyme complex | IDA PMID:12135483 Differential regulation of telomerase activity by six telome... | ACCEPT | Summary: TERT as holoenzyme component with differential subunit regulation. Supporting Evidence: PMID:12135483 Differential regulation of telomerase activity by six telomerase subunits. |
| GO:0042162 telomeric DNA binding | TAS PMID:9288757 hEST2, the putative human telomerase catalytic subunit gene,... | ACCEPT | Summary: TERT (hEST2) binds telomeric DNA substrate. Supporting Evidence: PMID:9288757 hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. |
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Download this section (compressed HTML)Q: What is the physiological significance of the TERT-RMRP RdRP complex?
Suggested experts: telomerase biology, RNA biology
Q: How significant are TERT's non-canonical functions (Wnt signaling, mitochondrial protection) relative to its telomerase function?
Suggested experts: cancer biology, aging research
Experiment: Separation-of-function TERT mutants that retain telomerase activity but lack RdRP activity to assess in vivo importance of non-canonical functions.
Hypothesis: Non-canonical TERT functions contribute to cellular fitness independent of telomere maintenance.
Type: genetic
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