TMED10 (TMP21 / p23 / p24-delta) is a type I single-pass membrane glycoprotein of the p24/emp24/gp25L family that acts as a cargo receptor in the early secretory pathway. Through its lumenal GOLD domain it selects secretory cargo - notably GPI-anchored proteins, together with TMED2 - for packaging into COPII vesicles, and through its cytoplasmic tail it binds COPI and COPII coats and the ARF1 GTPase, participating in vesicle coat formation; it cycles between the endoplasmic reticulum, the ER-Golgi intermediate compartment and the Golgi. TMED10 can also oligomerize into a protein-conducting channel that translocates leaderless cytoplasmic proteins (such as IL-1beta) into the ERGIC for unconventional secretion, and it is a component of the presenilin/gamma-secretase complex that modulates its activity.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000139 Golgi membrane | EXP PMID:10852829 Coupled transport of p24 family members. | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | EXP PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | EXP PMID:21219331 Proteinase-activated receptors, nucleotide P2Y receptors, an... | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | EXP PMID:9382861 Involvement of the transmembrane protein p23 in biosynthetic... | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | EXP PMID:9472029 gp25L/emp24/p24 protein family members of the cis-Golgi netw... | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-6809006 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-6809010 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-6809011 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-6811417 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0000139 Golgi membrane | TAS Reactome:R-HSA-6811418 | ACCEPT | Summary: Golgi membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005515 protein binding | IPI PMID:10359607 Localization and recycling of gp27 (hp24gamma3): complex for... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:16595549 Evidence for a role of transmembrane protein p25 in localiza... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:18287528 The cargo receptors Surf4, endoplasmic reticulum-Golgi inter... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:19837036 GPI glycan remodeling by PGAP5 regulates transport of GPI-an... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:20427317 Selective export of human GPI-anchored proteins from the end... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:23434013 The enterohemorrhagic Escherichia coli effector protein NleF... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:25959826 Quantitative interaction proteomics of neurodegenerative dis... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:31455601 RAB21 interacts with TMED10 and modulates its localization a... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI), many partners. Reason: GO:0005515 is uninformative; removal follows the protein-binding policy and does not dispute the interactions. TMED10 informative interactions (TMED2, syntaxin, gamma-secretase) are captured by specific terms. |
| GO:0005783 endoplasmic reticulum | IBA GO_REF:0000033 | ACCEPT | Summary: endoplasmic reticulum - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005783 endoplasmic reticulum | IDA PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: endoplasmic reticulum - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | EXP PMID:10852829 Coupled transport of p24 family members. | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | EXP PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | EXP PMID:9472029 gp25L/emp24/p24 protein family members of the cis-Golgi netw... | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000044 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-203973 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-204008 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5694410 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5694417 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5694522 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-5694527 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-6811423 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005789 endoplasmic reticulum membrane | TAS Reactome:R-HSA-6811427 | ACCEPT | Summary: endoplasmic reticulum membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005793 endoplasmic reticulum-Golgi intermediate compartment | IBA GO_REF:0000033 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005793 endoplasmic reticulum-Golgi intermediate compartment | IDA PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005793 endoplasmic reticulum-Golgi intermediate compartment | IDA PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005793 endoplasmic reticulum-Golgi intermediate compartment | IEA GO_REF:0000117 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005794 Golgi apparatus | IBA GO_REF:0000033 | ACCEPT | Summary: Golgi apparatus - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005794 Golgi apparatus | IDA GO_REF:0000052 | ACCEPT | Summary: Golgi apparatus - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005794 Golgi apparatus | IDA PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: Golgi apparatus - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005794 Golgi apparatus | IEA GO_REF:0000044 | ACCEPT | Summary: Golgi apparatus - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005801 cis-Golgi network | ISS GO_REF:0000024 | ACCEPT | Summary: cis-Golgi network - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | MARK AS OVER ANNOTATED | Summary: Plasma membrane (ortholog ISS / SubCell IEA). Reason: TMED10 is an early-secretory-pathway (ER/ERGIC/Golgi) cargo receptor, not a plasma-membrane-resident protein. Its link to the surface is that it chaperones certain GPCRs there; a steady-state PM location overstates the evidence. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: Plasma membrane (ortholog ISS / SubCell IEA). Reason: TMED10 is an early-secretory-pathway (ER/ERGIC/Golgi) cargo receptor, not a plasma-membrane-resident protein. Its link to the surface is that it chaperones certain GPCRs there; a steady-state PM location overstates the evidence. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0006886 intracellular protein transport | IBA GO_REF:0000033 | ACCEPT | Summary: intracellular protein transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0006886 intracellular protein transport | IDA PMID:20427317 Selective export of human GPI-anchored proteins from the end... | ACCEPT | Summary: intracellular protein transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport | IBA GO_REF:0000033 | ACCEPT | Summary: endoplasmic reticulum to Golgi vesicle-mediated transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport | TAS PMID:20427317 Selective export of human GPI-anchored proteins from the end... | ACCEPT | Summary: endoplasmic reticulum to Golgi vesicle-mediated transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | ISS GO_REF:0000024 | ACCEPT | Summary: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0007030 Golgi organization | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Golgi organization. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0007030 Golgi organization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Golgi organization. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0008320 transmembrane protein transporter activity | IMP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | ACCEPT | Summary: transmembrane protein transporter activity. Reason: Core: TMED10 oligomerizes into a protein-conducting channel for unconventional secretion (TMED10-channeled UPS). Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt may also CC act as a protein channel after oligomerization, facilitating the post- |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-203973 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-5694409 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-5694418 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-5694439 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-5694441 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0012507 ER to Golgi transport vesicle membrane | TAS Reactome:R-HSA-5694446 | ACCEPT | Summary: ER-to-Golgi transport vesicle membrane, a core site of the p24 cargo-receptor function. Reason: TMED10 is a p24-family cargo receptor that cycles in COPI/COPII transport vesicles between the ER, ERGIC and Golgi; the transport-vesicle membrane is where it captures and releases cargo, so this is a core location of its function rather than a peripheral one. |
| GO:0016020 membrane | ISS GO_REF:0000024 | TOO GENERAL | Summary: Membrane (ISS). Reason: Uninformative; the specific ER, ERGIC and Golgi membrane locations are asserted elsewhere in this review. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0019905 syntaxin binding | IPI PMID:21545355 Syntaxin 17 cycles between the ER and ERGIC and is required ... | KEEP AS NON CORE | Summary: syntaxin binding. Reason: An IPI interaction with syntaxin 17 (Q9Z158), a real but non-core SNARE/trafficking-machinery binding rather than the core cargo-receptor activity; TMED10 is the p23 subunit in this interaction. Supporting Evidence: PMID:21545355 Syntaxin 17 showed direct interaction with transmembrane proteins p23 and p25 |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6807877 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6809003 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6809006 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6811418 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6811423 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030133 transport vesicle | TAS Reactome:R-HSA-6811426 | TOO GENERAL | Summary: transport vesicle. Reason: True but less specific than the core location this review already asserts; the specific COPI/COPII and ER to Golgi transport-vesicle terms, with GO:0012507 transport vesicle membrane, name this compartment at the granularity the cargo-receptor function requires. |
| GO:0030134 COPII-coated ER to Golgi transport vesicle | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: COPII-coated ER to Golgi transport vesicle. Reason: The COPII-coated ER to Golgi vesicle is one coat variant of the transport vesicles in which TMED10 performs anterograde cargo-receptor cycling; part of the same core itinerary rather than a peripheral location, with the canonical core vesicle-membrane location captured by GO:0012507. |
| GO:0030137 COPI-coated vesicle | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: COPI-coated vesicle. Reason: The COPI-coated vesicle is the retrograde coat variant of the transport vesicles in which TMED10 performs cargo-receptor cycling; part of the same core itinerary rather than a peripheral location, with the canonical core vesicle-membrane location captured by GO:0012507. |
| GO:0030137 COPI-coated vesicle | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: COPI-coated vesicle. Reason: The COPI-coated vesicle is the retrograde coat variant of the transport vesicles in which TMED10 performs cargo-receptor cycling; part of the same core itinerary rather than a peripheral location, with the canonical core vesicle-membrane location captured by GO:0012507. |
| GO:0030140 trans-Golgi network transport vesicle | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: trans-Golgi network transport vesicle. Reason: The trans-Golgi network transport vesicle is a source variant within TMED10's cargo-receptor cycling itinerary; part of the same core vesicle system rather than a peripheral location, with the canonical core vesicle-membrane location captured by GO:0012507. |
| GO:0030658 transport vesicle membrane | IEA GO_REF:0000044 | TOO GENERAL | Summary: transport vesicle membrane. Reason: True but less specific than the core location this review already asserts; GO:0012507 ER to Golgi transport vesicle membrane names the same cargo-carrying vesicle membrane at the granularity TMED10's cargo-receptor function requires. |
| GO:0030667 secretory granule membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: secretory granule membrane. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0030667 secretory granule membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: secretory granule membrane. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0032732 positive regulation of interleukin-1 production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of interleukin-1 production. Reason: IL-1-beta is a canonical leaderless cargo exported by TMED10's unconventional-secretion channel, which this entry names as a core function; this IL-1 output belongs to that channel role rather than being peripheral to the cargo-receptor function. |
| GO:0032732 positive regulation of interleukin-1 production | IMP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | KEEP AS NON CORE | Summary: positive regulation of interleukin-1 production. Reason: IL-1-beta is a canonical leaderless cargo exported by TMED10's unconventional-secretion channel, which this entry names as a core function; this IL-1 output belongs to that channel role rather than being peripheral to the cargo-receptor function. Supporting Evidence: PMID:32272059 We identify TMED10 as a protein channel for the vesicle entry and secretion of many leaderless cargoes |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | EXP PMID:12237308 Oligomeric state and stoichiometry of p24 proteins in the ea... | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | EXP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | EXP PMID:9382861 Involvement of the transmembrane protein p23 in biosynthetic... | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | IEA GO_REF:0000044 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | TAS Reactome:R-HSA-5694446 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | TAS Reactome:R-HSA-6807875 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane | TAS Reactome:R-HSA-6807877 | ACCEPT | Summary: endoplasmic reticulum-Golgi intermediate compartment membrane - early secretory pathway residence of TMED10. Reason: Core location of this cycling p24-family cargo receptor. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0035459 vesicle cargo loading | TAS PMID:20427317 Selective export of human GPI-anchored proteins from the end... | ACCEPT | Summary: vesicle cargo loading. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0035964 COPI-coated vesicle budding | IDA PMID:10052452 Coupling of coat assembly and vesicle budding to packaging o... | ACCEPT | Summary: COPI-coated vesicle budding. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0042470 melanosome | EXP PMID:17081065 Proteomic and bioinformatic characterization of the biogenes... | KEEP AS NON CORE | Summary: melanosome. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0042470 melanosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: melanosome. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0042589 zymogen granule membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: zymogen granule membrane. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0042589 zymogen granule membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: zymogen granule membrane. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0045055 regulated exocytosis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulated exocytosis. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0045055 regulated exocytosis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulated exocytosis. Reason: A genuine but non-core/transient location or secondary role of TMED10, downstream of or peripheral to its core early-secretory-pathway cargo-receptor function. |
| GO:0048193 Golgi vesicle transport | IEA GO_REF:0000107 | TOO GENERAL | Summary: Golgi vesicle transport. Reason: True but less specific than the core transport process this review asserts; GO:0006888 ER to Golgi vesicle-mediated transport, accepted as core, entails this general Golgi vesicle transport term. |
| GO:0048193 Golgi vesicle transport | ISS GO_REF:0000024 | TOO GENERAL | Summary: Golgi vesicle transport. Reason: True but less specific than the core transport process this review asserts; GO:0006888 ER to Golgi vesicle-mediated transport, accepted as core, entails this general Golgi vesicle transport term. |
| GO:0048205 COPI coating of Golgi vesicle | TAS PMID:10761932 Decoding of sorting signals by coatomer through a GTPase swi... | ACCEPT | Summary: COPI coating of Golgi vesicle. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0048208 COPII vesicle coat assembly | TAS PMID:20427317 Selective export of human GPI-anchored proteins from the end... | ACCEPT | Summary: COPII vesicle coat assembly. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0050714 positive regulation of protein secretion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of protein secretion. Reason: Positive regulation of protein secretion is the process output of TMED10's unconventional-secretion channel (named as a core function of this entry), which exports leaderless cargoes; tied to that channel role rather than peripheral to the cargo-receptor function. |
| GO:0050714 positive regulation of protein secretion | IMP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | KEEP AS NON CORE | Summary: positive regulation of protein secretion. Reason: Positive regulation of protein secretion is the process output of TMED10's unconventional-secretion channel (named as a core function of this entry), which exports leaderless cargoes; tied to that channel role rather than peripheral to the cargo-receptor function. Supporting Evidence: PMID:32272059 We identify TMED10 as a protein channel for the vesicle entry and secretion of many leaderless cargoes |
| GO:0070765 gamma-secretase complex | IDA PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | KEEP AS NON CORE | Summary: gamma-secretase complex. Reason: TMED10 (TMP21) is a component of presenilin/gamma-secretase complexes and modulates gamma-secretase cleavage; a real secondary (moonlighting) role distinct from its core early-secretory cargo-receptor function. Supporting Evidence: PMID:16641999 TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes |
| GO:0070765 gamma-secretase complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: gamma-secretase complex. Reason: TMED10 (TMP21) is a component of presenilin/gamma-secretase complexes and modulates gamma-secretase cleavage; a real secondary (moonlighting) role distinct from its core early-secretory cargo-receptor function. Supporting Evidence: PMID:16641999 TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes |
| GO:0071806 protein transmembrane transport | IEA GO_REF:0000108 | ACCEPT | Summary: protein transmembrane transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0106272 protein localization to ERGIC | IMP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | ACCEPT | Summary: protein localization to ERGIC. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:0106273 cytosol to ERGIC protein transport | IMP PMID:32272059 A Translocation Pathway for Vesicle-Mediated Unconventional ... | ACCEPT | Summary: cytosol to ERGIC protein transport. Reason: Core function of TMED10 as a p24 cargo receptor / protein channel in the early secretory pathway. Supporting Evidence: file:human/TMED10/TMED10-uniprot.txt Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi |
| GO:1902003 regulation of amyloid-beta formation | IMP PMID:16641999 TMP21 is a presenilin complex component that modulates gamma... | KEEP AS NON CORE | Summary: regulation of amyloid-beta formation. Reason: TMED10 (TMP21) differentially regulates gamma-secretase cleavage of APP, which generates amyloid-beta; a real secondary role of the gamma-secretase moonlighting function, distinct from the core cargo-receptor function. Supporting Evidence: PMID:16641999 differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity |
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Experiment: Reconstitute TMED10 oligomers in proteoliposomes to measure protein-translocation channel activity and cargo selectivity, and map COPII cargo dependence in TMED10/TMED2 double-depleted cells.
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