TNKS

id: O95271
gene_symbol: TNKS
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for TNKS'
existing_annotations:
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070198
      label: protein localization to chromosome, telomeric region
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904355
      label: positive regulation of telomere capping
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000209
      label: protein polyubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000242
      label: pericentriolar material
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000781
      label: chromosome, telomeric region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000922
      label: spindle pole
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005635
      label: nuclear envelope
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005643
      label: nuclear pore
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0015031
      label: protein transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016055
      label: Wnt signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016740
      label: transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016757
      label: glycosyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016779
      label: nucleotidyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032212
      label: positive regulation of telomere maintenance via telomerase
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051028
      label: mRNA transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051301
      label: cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070198
      label: protein localization to chromosome, telomeric region
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070212
      label: protein poly-ADP-ribosylation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070213
      label: protein auto-ADP-ribosylation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140806
      label: NAD+-protein-aspartate ADP-ribosyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000116
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140807
      label: NAD+-protein-glutamate ADP-ribosyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000116
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904355
      label: positive regulation of telomere capping
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904357
      label: negative regulation of telomere maintenance via telomere 
        lengthening
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990404
      label: NAD+-protein mono-ADP-ribosyltransferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12080061
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12080061
          supporting_text: 2002 Jun 21. Identification of a tankyrase-binding 
            motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14596906
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14596906
          supporting_text: The formin-binding protein 17, FBP17, binds via a 
            TNKS binding motif to tankyrase, a protein involved in telomere 
            maintenance.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17003112
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17003112
          supporting_text: Posttranslational hydroxylation of ankyrin repeats in
            IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl 
            hydroxylase, factor inhibiting HIF (FIH).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17043677
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17043677
          supporting_text: 'Oct 17. Disrupted in Schizophrenia 1 Interactome: evidence
            for the close connectivity of risk genes and a potential synaptic basis
            for schizophrenia.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19759537
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19759537
          supporting_text: Tankyrase inhibition stabilizes axin and antagonizes 
            Wnt signalling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20696165
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20696165
          supporting_text: Epub 2010 Aug 7. Tankyrase-1 assembly to large 
            protein complexes blocks its telomeric function.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21251231
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21251231
          supporting_text: 2011 Feb 23. Factor-inhibiting hypoxia-inducible 
            factor (FIH) catalyses the post-translational hydroxylation of 
            histidinyl residues within ankyrin repeat domains.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21799911
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21799911
          supporting_text: Ubiquitin ligase RNF146 regulates tankyrase and Axin 
            to promote Wnt signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22699936
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22699936
          supporting_text: Tankyrase 1 regulates centrosome function by 
            controlling CPAP stability.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25327252
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25327252
          supporting_text: Allosteric activation of the RNF146 ubiquitin ligase 
            by a poly(ADP-ribosyl)ation signal.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26373281
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26373281
          supporting_text: Loss of ATRX Suppresses Resolution of Telomere 
            Cohesion to Control Recombination in ALT Cancer Cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26496610
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26496610
          supporting_text: Oct 22. A human interactome in three quantitative 
            dimensions organized by stoichiometries and abundances.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26972000
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26972000
          supporting_text: 2016 Mar 10. Substrate-Trapped Interactors of PHD3 
            and FIH Cluster in Distinct Signaling Pathways.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28514442
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28514442
          supporting_text: Architecture of the human interactome defines protein
            communities and disease networks.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31413325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31413325
          supporting_text: HENA, heterogeneous network-based data set for 
            Alzheimer's disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-4641257
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8948800
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010521
      label: telomerase inhibitor activity
    evidence_type: IMP
    original_reference_id: PMID:25939383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25939383
          supporting_text: May 4. Disruption of Wnt/β-Catenin Signaling and 
            Telomeric Shortening Are Inextricable Consequences of Tankyrase 
            Inhibition in Human Cells.
  - term:
      id: GO:0010521
      label: telomerase inhibitor activity
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:0032210
      label: regulation of telomere maintenance via telomerase
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:1904358
      label: positive regulation of telomere maintenance via telomere 
        lengthening
    evidence_type: IDA
    original_reference_id: PMID:12782650
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12782650
          supporting_text: TRF1 is degraded by ubiquitin-mediated proteolysis 
            after release from telomeres.
  - term:
      id: GO:1990404
      label: NAD+-protein mono-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:15133513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15133513
          supporting_text: TIN2 is a tankyrase 1 PARP modulator in the TRF1 
            telomere length control complex.
  - term:
      id: GO:1990404
      label: NAD+-protein mono-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:0070212
      label: protein poly-ADP-ribosylation
    evidence_type: IDA
    original_reference_id: PMID:25043379
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25043379
          supporting_text: Family-wide analysis of poly(ADP-ribose) polymerase 
            activity.
  - term:
      id: GO:1990404
      label: NAD+-protein mono-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:25043379
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25043379
          supporting_text: Family-wide analysis of poly(ADP-ribose) polymerase 
            activity.
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:16076287
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16076287
          supporting_text: NuMA is a major acceptor of poly(ADP-ribosyl)ation by
            tankyrase 1 in mitosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16076287
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16076287
          supporting_text: NuMA is a major acceptor of poly(ADP-ribosyl)ation by
            tankyrase 1 in mitosis.
  - term:
      id: GO:0070212
      label: protein poly-ADP-ribosylation
    evidence_type: IDA
    original_reference_id: PMID:16076287
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16076287
          supporting_text: NuMA is a major acceptor of poly(ADP-ribosyl)ation by
            tankyrase 1 in mitosis.
  - term:
      id: GO:0097431
      label: mitotic spindle pole
    evidence_type: IDA
    original_reference_id: PMID:16076287
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16076287
          supporting_text: NuMA is a major acceptor of poly(ADP-ribosyl)ation by
            tankyrase 1 in mitosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11854288
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11854288
          supporting_text: 2002 Feb 19. The telomeric poly(ADP-ribose) 
            polymerase, tankyrase 1, contains multiple binding sites for 
            telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 
            182-kDa tankyrase-binding protein (TAB182).
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:11854288
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11854288
          supporting_text: 2002 Feb 19. The telomeric poly(ADP-ribose) 
            polymerase, tankyrase 1, contains multiple binding sites for 
            telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 
            182-kDa tankyrase-binding protein (TAB182).
  - term:
      id: GO:1904908
      label: negative regulation of maintenance of mitotic sister chromatid 
        cohesion, telomeric
    evidence_type: IMP
    original_reference_id: PMID:26373281
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26373281
          supporting_text: Loss of ATRX Suppresses Resolution of Telomere 
            Cohesion to Control Recombination in ALT Cancer Cells.
  - term:
      id: GO:0000781
      label: chromosome, telomeric region
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:0042393
      label: histone binding
    evidence_type: IPI
    original_reference_id: PMID:26373281
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26373281
          supporting_text: Loss of ATRX Suppresses Resolution of Telomere 
            Cohesion to Control Recombination in ALT Cancer Cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15133513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15133513
          supporting_text: TIN2 is a tankyrase 1 PARP modulator in the TRF1 
            telomere length control complex.
  - term:
      id: GO:0032212
      label: positive regulation of telomere maintenance via telomerase
    evidence_type: IDA
    original_reference_id: PMID:12782650
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12782650
          supporting_text: TRF1 is degraded by ubiquitin-mediated proteolysis 
            after release from telomeres.
  - term:
      id: GO:0070198
      label: protein localization to chromosome, telomeric region
    evidence_type: IMP
    original_reference_id: PMID:15133513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15133513
          supporting_text: TIN2 is a tankyrase 1 PARP modulator in the TRF1 
            telomere length control complex.
  - term:
      id: GO:0070212
      label: protein poly-ADP-ribosylation
    evidence_type: IMP
    original_reference_id: PMID:25939383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25939383
          supporting_text: May 4. Disruption of Wnt/β-Catenin Signaling and 
            Telomeric Shortening Are Inextricable Consequences of Tankyrase 
            Inhibition in Human Cells.
  - term:
      id: GO:0070212
      label: protein poly-ADP-ribosylation
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:1904357
      label: negative regulation of telomere maintenance via telomere 
        lengthening
    evidence_type: IMP
    original_reference_id: PMID:25939383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25939383
          supporting_text: May 4. Disruption of Wnt/β-Catenin Signaling and 
            Telomeric Shortening Are Inextricable Consequences of Tankyrase 
            Inhibition in Human Cells.
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:25939383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25939383
          supporting_text: May 4. Disruption of Wnt/β-Catenin Signaling and 
            Telomeric Shortening Are Inextricable Consequences of Tankyrase 
            Inhibition in Human Cells.
  - term:
      id: GO:1904355
      label: positive regulation of telomere capping
    evidence_type: IMP
    original_reference_id: PMID:25939383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25939383
          supporting_text: May 4. Disruption of Wnt/β-Catenin Signaling and 
            Telomeric Shortening Are Inextricable Consequences of Tankyrase 
            Inhibition in Human Cells.
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:21270334
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21270334
          supporting_text: Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in 
            cellular response to DNA damage and mitotic progression.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640844
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640862
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640872
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3640874
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5262606
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8948800
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:22864114
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22864114
          supporting_text: 2012 Aug 2. Poly-ADP ribosylation of Miki by 
            tankyrase-1 promotes centrosome maturation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22864114
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22864114
          supporting_text: 2012 Aug 2. Poly-ADP ribosylation of Miki by 
            tankyrase-1 promotes centrosome maturation.
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: IDA
    original_reference_id: PMID:22864114
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22864114
          supporting_text: 2012 Aug 2. Poly-ADP ribosylation of Miki by 
            tankyrase-1 promotes centrosome maturation.
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:19245366
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19245366
          supporting_text: MYPT1, the targeting subunit of smooth-muscle myosin 
            phosphatase, is a substrate for the asparaginyl hydroxylase factor 
            inhibiting hypoxia-inducible factor (FIH).
  - term:
      id: GO:0000209
      label: protein polyubiquitination
    evidence_type: IDA
    original_reference_id: PMID:19759537
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19759537
          supporting_text: Tankyrase inhibition stabilizes axin and antagonizes 
            Wnt signalling.
  - term:
      id: GO:0000209
      label: protein polyubiquitination
    evidence_type: IDA
    original_reference_id: PMID:21478859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21478859
          supporting_text: RNF146 is a poly(ADP-ribose)-directed E3 ligase that 
            regulates axin degradation and Wnt signalling.
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:19759537
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19759537
          supporting_text: Tankyrase inhibition stabilizes axin and antagonizes 
            Wnt signalling.
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:21478859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21478859
          supporting_text: RNF146 is a poly(ADP-ribose)-directed E3 ligase that 
            regulates axin degradation and Wnt signalling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21478859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21478859
          supporting_text: RNF146 is a poly(ADP-ribose)-directed E3 ligase that 
            regulates axin degradation and Wnt signalling.
  - term:
      id: GO:0070213
      label: protein auto-ADP-ribosylation
    evidence_type: IDA
    original_reference_id: PMID:21478859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21478859
          supporting_text: RNF146 is a poly(ADP-ribose)-directed E3 ligase that 
            regulates axin degradation and Wnt signalling.
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:19759537
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19759537
          supporting_text: Tankyrase inhibition stabilizes axin and antagonizes 
            Wnt signalling.
  - term:
      id: GO:0070198
      label: protein localization to chromosome, telomeric region
    evidence_type: IMP
    original_reference_id: PMID:18221737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18221737
          supporting_text: Epub 2007 Dec 14. Telomere elongation by a mutant 
            tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
  - term:
      id: GO:0000242
      label: pericentriolar material
    evidence_type: TAS
    original_reference_id: PMID:11454873
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11454873
          supporting_text: 2001 Jul 13. TANK2, a new TRF1-associated 
            poly(ADP-ribose) polymerase, causes rapid induction of cell death 
            upon overexpression.
  - term:
      id: GO:0000781
      label: chromosome, telomeric region
    evidence_type: IDA
    original_reference_id: PMID:11739745
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11739745
          supporting_text: Role for the related poly(ADP-Ribose) polymerases 
            tankyrase 1 and 2 at human telomeres.
  - term:
      id: GO:0005643
      label: nuclear pore
    evidence_type: TAS
    original_reference_id: PMID:11454873
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11454873
          supporting_text: 2001 Jul 13. TANK2, a new TRF1-associated 
            poly(ADP-ribose) polymerase, causes rapid induction of cell death 
            upon overexpression.
  - term:
      id: GO:0007052
      label: mitotic spindle organization
    evidence_type: TAS
    original_reference_id: PMID:17026964
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17026964
          supporting_text: Mitotic phosphorylation of tankyrase, a PARP that 
            promotes spindle assembly, by GSK3.
  - term:
      id: GO:0008270
      label: zinc ion binding
    evidence_type: IDA
    original_reference_id: PMID:18436240
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18436240
          supporting_text: 2008 Apr 3. Zinc binding catalytic domain of human 
            tankyrase 1.
  - term:
      id: GO:0031965
      label: nuclear membrane
    evidence_type: TAS
    original_reference_id: PMID:11454873
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11454873
          supporting_text: 2001 Jul 13. TANK2, a new TRF1-associated 
            poly(ADP-ribose) polymerase, causes rapid induction of cell death 
            upon overexpression.
  - term:
      id: GO:0032212
      label: positive regulation of telomere maintenance via telomerase
    evidence_type: IMP
    original_reference_id: PMID:11739745
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11739745
          supporting_text: Role for the related poly(ADP-Ribose) polymerases 
            tankyrase 1 and 2 at human telomeres.
  - term:
      id: GO:0032212
      label: positive regulation of telomere maintenance via telomerase
    evidence_type: IDA
    original_reference_id: PMID:18221737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18221737
          supporting_text: Epub 2007 Dec 14. Telomere elongation by a mutant 
            tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
  - term:
      id: GO:0051225
      label: spindle assembly
    evidence_type: TAS
    original_reference_id: PMID:17026964
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17026964
          supporting_text: Mitotic phosphorylation of tankyrase, a PARP that 
            promotes spindle assembly, by GSK3.
  - term:
      id: GO:0018105
      label: peptidyl-serine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17026964
    review:
      summary: >-
        MISANNOTATION: TNKS (tankyrase-1) is a Poly ADP-ribose polymerase (PARP, EC
        2.4.2.30) that performs poly-ADP-ribosylation, NOT phosphorylation. PMID:17026964
        title is "Mitotic phosphorylation of tankyrase... by GSK3" - TNKS is the SUBSTRATE
        of GSK3 kinase. The paper states "GSK3 in vitro phosphorylates tankyrase on
        S978,
        T982, S987, and S991". TNKS has no kinase activity - it is a PARP enzyme.
      action: REMOVE
      supported_by:
        - reference_id: PMID:17026964
          supporting_text: Mitotic phosphorylation of tankyrase, a PARP that 
            promotes spindle assembly, by GSK3.
  - term:
      id: GO:0018107
      label: peptidyl-threonine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:17026964
    review:
      summary: >-
        MISANNOTATION: TNKS (tankyrase-1) is a Poly ADP-ribose polymerase (PARP, EC
        2.4.2.30), not a kinase. PMID:17026964 describes GSK3 phosphorylating tankyrase
        at threonine residues (T982) - TNKS is the SUBSTRATE, GSK3 is the kinase.
        The
        actual enzymatic activity of TNKS is poly-ADP-ribosylation (GO:0003950).
      action: REMOVE
      supported_by:
        - reference_id: PMID:17026964
          supporting_text: Mitotic phosphorylation of tankyrase, a PARP that 
            promotes spindle assembly, by GSK3.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12768206
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12768206
          supporting_text: POT1 as a terminal transducer of TRF1 telomere length
            control.
  - term:
      id: GO:0003950
      label: NAD+ poly-ADP-ribosyltransferase activity
    evidence_type: IDA
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9822378
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9822378
          supporting_text: Tankyrase, a poly(ADP-ribose) polymerase at human 
            telomeres.
references:
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000116
    title: Automatic Gene Ontology annotation based on Rhea mapping
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:11454873
    title: TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes 
      rapid induction of cell death upon overexpression.
    findings: []
  - id: PMID:11739745
    title: >-
      Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human
      telomeres.
    findings: []
  - id: PMID:11854288
    title: The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains 
      multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a 
      novel acceptor, 182-kDa tankyrase-binding protein (TAB182).
    findings: []
  - id: PMID:12080061
    title: Identification of a tankyrase-binding motif shared by IRAP, TAB182, 
      and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is 
      a novel tankyrase partner.
    findings: []
  - id: PMID:12768206
    title: POT1 as a terminal transducer of TRF1 telomere length control.
    findings: []
  - id: PMID:12782650
    title: TRF1 is degraded by ubiquitin-mediated proteolysis after release from
      telomeres.
    findings: []
  - id: PMID:14596906
    title: The formin-binding protein 17, FBP17, binds via a TNKS binding motif 
      to tankyrase, a protein involved in telomere maintenance.
    findings: []
  - id: PMID:15133513
    title: TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length 
      control complex.
    findings: []
  - id: PMID:16076287
    title: NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in 
      mitosis.
    findings: []
  - id: PMID:17003112
    title: Posttranslational hydroxylation of ankyrin repeats in IkappaB 
      proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, 
      factor inhibiting HIF (FIH).
    findings: []
  - id: PMID:17026964
    title: Mitotic phosphorylation of tankyrase, a PARP that promotes spindle 
      assembly, by GSK3.
    findings: []
  - id: PMID:17043677
    title: 'Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity
      of risk genes and a potential synaptic basis for schizophrenia.'
    findings: []
  - id: PMID:18221737
    title: Telomere elongation by a mutant tankyrase 1 without TRF1 
      poly(ADP-ribosyl)ation.
    findings: []
  - id: PMID:18436240
    title: Zinc binding catalytic domain of human tankyrase 1.
    findings: []
  - id: PMID:19245366
    title: MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is 
      a substrate for the asparaginyl hydroxylase factor inhibiting 
      hypoxia-inducible factor (FIH).
    findings: []
  - id: PMID:19759537
    title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
    findings: []
  - id: PMID:20696165
    title: Tankyrase-1 assembly to large protein complexes blocks its telomeric 
      function.
    findings: []
  - id: PMID:21251231
    title: Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the 
      post-translational hydroxylation of histidinyl residues within ankyrin 
      repeat domains.
    findings: []
  - id: PMID:21270334
    title: Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular 
      response to DNA damage and mitotic progression.
    findings: []
  - id: PMID:21478859
    title: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin 
      degradation and Wnt signalling.
    findings: []
  - id: PMID:21799911
    title: Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt 
      signaling.
    findings: []
  - id: PMID:22699936
    title: Tankyrase 1 regulates centrosome function by controlling CPAP 
      stability.
    findings: []
  - id: PMID:22864114
    title: Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome 
      maturation.
    findings: []
  - id: PMID:25043379
    title: Family-wide analysis of poly(ADP-ribose) polymerase activity.
    findings: []
  - id: PMID:25327252
    title: Allosteric activation of the RNF146 ubiquitin ligase by a 
      poly(ADP-ribosyl)ation signal.
    findings: []
  - id: PMID:25939383
    title: Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are 
      Inextricable Consequences of Tankyrase Inhibition in Human Cells.
    findings: []
  - id: PMID:26373281
    title: Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control 
      Recombination in ALT Cancer Cells.
    findings: []
  - id: PMID:26496610
    title: A human interactome in three quantitative dimensions organized by 
      stoichiometries and abundances.
    findings: []
  - id: PMID:26972000
    title: Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct 
      Signaling Pathways.
    findings: []
  - id: PMID:28514442
    title: Architecture of the human interactome defines protein communities and
      disease networks.
    findings: []
  - id: PMID:31413325
    title: HENA, heterogeneous network-based data set for Alzheimer's disease.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []
  - id: PMID:9822378
    title: Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.
    findings: []
  - id: Reactome:R-HSA-3640844
    title: RNF146 binds RibC-AXIN:TNKS complex
    findings: []
  - id: Reactome:R-HSA-3640858
    title: Tankyrase ADP-ribosylates AXIN
    findings: []
  - id: Reactome:R-HSA-3640861
    title: RNF146 ubiquitinates ADP-ribosylated AXIN
    findings: []
  - id: Reactome:R-HSA-3640862
    title: Tankyrase binds AXIN
    findings: []
  - id: Reactome:R-HSA-3640872
    title: USP34 deubiquitinates AXIN1,AXIN2
    findings: []
  - id: Reactome:R-HSA-3640874
    title: Ub-RibC-AXIN is degraded by the proteasome
    findings: []
  - id: Reactome:R-HSA-4641257
    title: Degradation of AXIN
    findings: []
  - id: Reactome:R-HSA-5262606
    title: XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling
    findings: []
  - id: Reactome:R-HSA-8948800
    title: TNKS and TNKS2 PARylate PTEN
    findings: []