TOLLIP

UniProt ID: Q9H0E2
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for TOLLIP

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043130 ubiquitin binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002376 immune system process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005768 endosome
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005769 early endosome
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006914 autophagy
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006954 inflammatory response
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043130 ubiquitin binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045087 innate immune response
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:14563850
Tom1, a VHS domain-containing protein, interacts with tollip... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14563850
2003 Oct 15. Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
GO:0005515 protein binding
IPI
PMID:16189514
Towards a proteome-scale map of the human protein-protein in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
GO:0005515 protein binding
IPI
PMID:16713569
A protein-protein interaction network for human inherited at... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
GO:0005515 protein binding
IPI
PMID:19060904
An empirical framework for binary interactome mapping. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19060904
An empirical framework for binary interactome mapping.
GO:0005515 protein binding
IPI
PMID:19447967
Shifted Transversal Design smart-pooling for high coverage i... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19447967
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
GO:0005515 protein binding
IPI
PMID:20936779
A human MAP kinase interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20936779
A human MAP kinase interactome.
GO:0005515 protein binding
IPI
PMID:21903422
Mapping a dynamic innate immunity protein interaction networ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21903422
2011 Sep 8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
GO:0005515 protein binding
IPI
PMID:21988832
Toward an understanding of the protein interaction network o... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
GO:0005515 protein binding
IPI
PMID:25042851
Autophagic clearance of polyQ proteins mediated by ubiquitin... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25042851
Jul 18. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25416956
A proteome-scale map of the human interactome network.
GO:0005515 protein binding
IPI
PMID:25910212
Widespread macromolecular interaction perturbations in human... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25910212
Widespread macromolecular interaction perturbations in human genetic disorders.
GO:0005515 protein binding
IPI
PMID:27107014
An inter-species protein-protein interaction network across ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:33961781
2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GO:0005515 protein binding
IPI
PMID:34524948
Global Proximity Interactome of the Human Macroautophagy Pat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:34524948
2021 Sep 15. Global Proximity Interactome of the Human Macroautophagy Pathway.
GO:0005515 protein binding
IPI
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human ce... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:35271311
2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization.
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:40205054
Apr 9. Multimodal cell maps as a foundation for structural and functional genomics.
GO:0005150 interleukin-1, type I receptor binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016604 nuclear body
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032183 SUMO binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032991 protein-containing complex
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033235 positive regulation of protein sumoylation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070498 interleukin-1-mediated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26320582
Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-P... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26320582
2015 Aug 27. Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
GO:0005515 protein binding
IPI
PMID:31263572
Dominant TOM1 mutation associated with combined immunodefici... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31263572
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.
GO:0005515 protein binding
IPI
PMID:15047686
Tollip and Tom1 form a complex and recruit ubiquitin-conjuga... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15047686
2004 Mar 26. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.
GO:0019897 extrinsic component of plasma membrane
IC
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
GO:0060090 molecular adaptor activity
IDA
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
GO:0070498 interleukin-1-mediated signaling pathway
IDA
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
GO:0060090 molecular adaptor activity
IDA
PMID:27368102
An ER-Associated Pathway Defines Endosomal Architecture for ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:27368102
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.
GO:0019900 kinase binding
IPI
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
GO:0032991 protein-containing complex
IDA
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
GO:0005515 protein binding
IPI
PMID:11397809
IRAK1b, a novel alternative splice variant of interleukin-1 ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11397809
2001 Jun 7. IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6798749 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6798751 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035578 azurophil granule lumen
TAS
Reactome:R-HSA-6798751 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035580 specific granule lumen
TAS
Reactome:R-HSA-6798749 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070062 extracellular exosome
HDA
PMID:23533145
In-depth proteomic analyses of exosomes isolated from expres... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23533145
2013 Apr 23. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
GO:0030855 epithelial cell differentiation
IEP
PMID:21492153
Analysis of proteomic changes induced upon cellular differen... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21492153
Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
GO:0005515 protein binding
IPI
PMID:16412388
Recruitment of clathrin onto endosomes by the Tom1-Tollip co... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16412388
Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
GO:0036010 protein localization to endosome
IDA
PMID:16412388
Recruitment of clathrin onto endosomes by the Tom1-Tollip co... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16412388
Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
GO:0070062 extracellular exosome
HDA
PMID:19056867
Large-scale proteomics and phosphoproteomics of urinary exos... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19056867
2008 Dec 3. Large-scale proteomics and phosphoproteomics of urinary exosomes.
GO:0005829 cytosol
TAS
Reactome:R-HSA-446634 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446684 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446692 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446694 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446701 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446862 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446868 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-446894 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IC
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
GO:0007165 signal transduction
IPI
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
GO:0035325 Toll-like receptor binding
IPI
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
GO:0016310 phosphorylation
IDA
PMID:1085432
Malignant lymphoma and rheumatic symptoms. 		REMOVE
Summary: MISANNOTATION with WRONG PMID: PMID:1085432 is about "Malignant lymphoma and rheumatic symptoms" from 1976 - completely unrelated to TOLLIP! Furthermore, TOLLIP is a signaling adapter protein, NOT a kinase. UniProt states TOLLIP "Inhibits IRAK1 phosphorylation and kinase activity" - it REGULATES kinases, not performs phosphorylation itself.
Supporting Evidence:
PMID:1085432
Malignant lymphoma and rheumatic symptoms.
GO:0045321 leukocyte activation
NAS
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
PMID:1085432
Malignant lymphoma and rheumatic symptoms.
PMID:10854325
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
PMID:11397809
IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
PMID:11441107
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
PMID:14563850
Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
PMID:15047686
Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
PMID:16412388
Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
PMID:16713569
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
PMID:19056867
Large-scale proteomics and phosphoproteomics of urinary exosomes.
PMID:19060904
An empirical framework for binary interactome mapping.
PMID:19447967
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
PMID:20936779
A human MAP kinase interactome.
PMID:21492153
Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
PMID:21903422
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:23533145
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
PMID:25042851
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:25910212
Widespread macromolecular interaction perturbations in human genetic disorders.
PMID:26320582
Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
PMID:27107014
An inter-species protein-protein interaction network across vast evolutionary distance.
PMID:27368102
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport.
PMID:31263572
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:34524948
Global Proximity Interactome of the Human Macroautophagy Pathway.
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human cellular organization.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.
Reactome:R-HSA-446634
IRAK4 is activated by autophosphorylation
Reactome:R-HSA-446684
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
Reactome:R-HSA-446692
IRAK1 binds to MYD88 within the IL1R complex
Reactome:R-HSA-446694
IRAK4 phosphorylates IRAK1
Reactome:R-HSA-446701
IRAK4-activated IRAK1 autophosphorylates
Reactome:R-HSA-446862
Hyperphosphorylated IRAK1 associates with TRAF6
Reactome:R-HSA-446868
The Interleukin 1 receptor complex binds Tollip
Reactome:R-HSA-446894
TRAF6 binding leads to IRAK1:TRAF6 release
Reactome:R-HSA-6798749
Exocytosis of specific granule lumen proteins
Reactome:R-HSA-6798751
Exocytosis of azurophil granule lumen proteins

📄 View Raw YAML

 
id: Q9H0E2
gene_symbol: TOLLIP
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for TOLLIP'
alternative_products:
  - id: Q9H0E2-1
    name: '1'
  - id: Q9H0E2-2
    name: '2'
existing_annotations:
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006511
      label: ubiquitin-dependent protein catabolic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031624
      label: ubiquitin conjugating enzyme binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043130
      label: ubiquitin binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002376
      label: immune system process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005768
      label: endosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005769
      label: early endosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006914
      label: autophagy
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043130
      label: ubiquitin binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14563850
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14563850
          supporting_text: 2003 Oct 15. Tom1, a VHS domain-containing protein, 
            interacts with tollip, ubiquitin, and clathrin.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16189514
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16189514
          supporting_text: Towards a proteome-scale map of the human 
            protein-protein interaction network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16713569
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16713569
          supporting_text: A protein-protein interaction network for human 
            inherited ataxias and disorders of Purkinje cell degeneration.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19060904
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19060904
          supporting_text: An empirical framework for binary interactome 
            mapping.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19447967
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19447967
          supporting_text: Shifted Transversal Design smart-pooling for high 
            coverage interactome mapping.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20936779
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20936779
          supporting_text: A human MAP kinase interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21903422
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21903422
          supporting_text: 2011 Sep 8. Mapping a dynamic innate immunity protein
            interaction network regulating type I interferon production.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21988832
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21988832
          supporting_text: Toward an understanding of the protein interaction 
            network of the human liver.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25042851
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25042851
          supporting_text: Jul 18. Autophagic clearance of polyQ proteins 
            mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein 
            family.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25416956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25416956
          supporting_text: A proteome-scale map of the human interactome 
            network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25910212
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25910212
          supporting_text: Widespread macromolecular interaction perturbations 
            in human genetic disorders.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27107014
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27107014
          supporting_text: An inter-species protein-protein interaction network 
            across vast evolutionary distance.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31515488
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31515488
          supporting_text: Extensive disruption of protein interactions by 
            genetic variants across the allele frequency spectrum in human 
            populations.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:34524948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34524948
          supporting_text: 2021 Sep 15. Global Proximity Interactome of the 
            Human Macroautophagy Pathway.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35271311
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:35271311
          supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography
            of human cellular organization.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0005150
      label: interleukin-1, type I receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016604
      label: nuclear body
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031624
      label: ubiquitin conjugating enzyme binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031625
      label: ubiquitin protein ligase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032183
      label: SUMO binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033235
      label: positive regulation of protein sumoylation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070498
      label: interleukin-1-mediated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26320582
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26320582
          supporting_text: 2015 Aug 27. Tom1 Modulates Binding of Tollip to 
            Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding 
            Mechanism.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31263572
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31263572
          supporting_text: Dominant TOM1 mutation associated with combined 
            immunodeficiency and autoimmune disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15047686
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15047686
          supporting_text: 2004 Mar 26. Tollip and Tom1 form a complex and 
            recruit ubiquitin-conjugated proteins onto early endosomes.
  - term:
      id: GO:0019897
      label: extrinsic component of plasma membrane
    evidence_type: IC
    original_reference_id: PMID:10854325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10854325
          supporting_text: Tollip, a new component of the IL-1RI pathway, links 
            IRAK to the IL-1 receptor.
  - term:
      id: GO:0060090
      label: molecular adaptor activity
    evidence_type: IDA
    original_reference_id: PMID:10854325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10854325
          supporting_text: Tollip, a new component of the IL-1RI pathway, links 
            IRAK to the IL-1 receptor.
  - term:
      id: GO:0070498
      label: interleukin-1-mediated signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:10854325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10854325
          supporting_text: Tollip, a new component of the IL-1RI pathway, links 
            IRAK to the IL-1 receptor.
  - term:
      id: GO:0060090
      label: molecular adaptor activity
    evidence_type: IDA
    original_reference_id: PMID:27368102
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27368102
          supporting_text: An ER-Associated Pathway Defines Endosomal 
            Architecture for Controlled Cargo Transport.
  - term:
      id: GO:0019900
      label: kinase binding
    evidence_type: IPI
    original_reference_id: PMID:10854325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10854325
          supporting_text: Tollip, a new component of the IL-1RI pathway, links 
            IRAK to the IL-1 receptor.
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IDA
    original_reference_id: PMID:10854325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10854325
          supporting_text: Tollip, a new component of the IL-1RI pathway, links 
            IRAK to the IL-1 receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11397809
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11397809
          supporting_text: 2001 Jun 7. IRAK1b, a novel alternative splice 
            variant of interleukin-1 receptor-associated kinase (IRAK), mediates
            interleukin-1 signaling and has prolonged stability.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035578
      label: azurophil granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798751
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035580
      label: specific granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:23533145
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23533145
          supporting_text: 2013 Apr 23. In-depth proteomic analyses of exosomes 
            isolated from expressed prostatic secretions in urine.
  - term:
      id: GO:0030855
      label: epithelial cell differentiation
    evidence_type: IEP
    original_reference_id: PMID:21492153
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21492153
          supporting_text: Analysis of proteomic changes induced upon cellular 
            differentiation of the human intestinal cell line Caco-2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16412388
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16412388
          supporting_text: Recruitment of clathrin onto endosomes by the 
            Tom1-Tollip complex.
  - term:
      id: GO:0036010
      label: protein localization to endosome
    evidence_type: IDA
    original_reference_id: PMID:16412388
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16412388
          supporting_text: Recruitment of clathrin onto endosomes by the 
            Tom1-Tollip complex.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:19056867
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19056867
          supporting_text: 2008 Dec 3. Large-scale proteomics and 
            phosphoproteomics of urinary exosomes.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446634
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446692
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446694
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446701
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446862
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446868
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-446894
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IC
    original_reference_id: PMID:11441107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11441107
          supporting_text: 'Cooperation of Toll-like receptor 2 and 6 for cellular
            activation by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and IL-1
            receptor signaling molecules in Toll-like receptor 2 signaling.'
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IPI
    original_reference_id: PMID:11441107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11441107
          supporting_text: 'Cooperation of Toll-like receptor 2 and 6 for cellular
            activation by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and IL-1
            receptor signaling molecules in Toll-like receptor 2 signaling.'
  - term:
      id: GO:0035325
      label: Toll-like receptor binding
    evidence_type: IPI
    original_reference_id: PMID:11441107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11441107
          supporting_text: 'Cooperation of Toll-like receptor 2 and 6 for cellular
            activation by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and IL-1
            receptor signaling molecules in Toll-like receptor 2 signaling.'
  - term:
      id: GO:0016310
      label: phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:1085432
    review:
      summary: >-
        MISANNOTATION with WRONG PMID: PMID:1085432 is about "Malignant lymphoma and
        rheumatic symptoms" from 1976 - completely unrelated to TOLLIP! Furthermore,
        TOLLIP is a signaling adapter protein, NOT a kinase. UniProt states TOLLIP
        "Inhibits IRAK1 phosphorylation and kinase activity" - it REGULATES kinases,
        not performs phosphorylation itself.
      action: REMOVE
      supported_by:
        - reference_id: PMID:1085432
          supporting_text: Malignant lymphoma and rheumatic symptoms.
  - term:
      id: GO:0045321
      label: leukocyte activation
    evidence_type: NAS
    original_reference_id: PMID:11441107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11441107
          supporting_text: 'Cooperation of Toll-like receptor 2 and 6 for cellular
            activation by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and IL-1
            receptor signaling molecules in Toll-like receptor 2 signaling.'
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: PMID:1085432
    title: Malignant lymphoma and rheumatic symptoms.
    findings: []
  - id: PMID:10854325
    title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1
      receptor.
    findings: []
  - id: PMID:11397809
    title: IRAK1b, a novel alternative splice variant of interleukin-1 
      receptor-associated kinase (IRAK), mediates interleukin-1 signaling and 
      has prolonged stability.
    findings: []
  - id: PMID:11441107
    title: 'Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble
      tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein:
      role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like
      receptor 2 signaling.'
    findings: []
  - id: PMID:14563850
    title: Tom1, a VHS domain-containing protein, interacts with tollip, 
      ubiquitin, and clathrin.
    findings: []
  - id: PMID:15047686
    title: Tollip and Tom1 form a complex and recruit ubiquitin-conjugated 
      proteins onto early endosomes.
    findings: []
  - id: PMID:16189514
    title: Towards a proteome-scale map of the human protein-protein interaction
      network.
    findings: []
  - id: PMID:16412388
    title: Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
    findings: []
  - id: PMID:16713569
    title: A protein-protein interaction network for human inherited ataxias and
      disorders of Purkinje cell degeneration.
    findings: []
  - id: PMID:19056867
    title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
    findings: []
  - id: PMID:19060904
    title: An empirical framework for binary interactome mapping.
    findings: []
  - id: PMID:19447967
    title: Shifted Transversal Design smart-pooling for high coverage 
      interactome mapping.
    findings: []
  - id: PMID:20936779
    title: A human MAP kinase interactome.
    findings: []
  - id: PMID:21492153
    title: Analysis of proteomic changes induced upon cellular differentiation 
      of the human intestinal cell line Caco-2.
    findings: []
  - id: PMID:21903422
    title: Mapping a dynamic innate immunity protein interaction network 
      regulating type I interferon production.
    findings: []
  - id: PMID:21988832
    title: Toward an understanding of the protein interaction network of the 
      human liver.
    findings: []
  - id: PMID:23533145
    title: In-depth proteomic analyses of exosomes isolated from expressed 
      prostatic secretions in urine.
    findings: []
  - id: PMID:25042851
    title: Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 
      adaptors of the conserved CUET protein family.
    findings: []
  - id: PMID:25416956
    title: A proteome-scale map of the human interactome network.
    findings: []
  - id: PMID:25910212
    title: Widespread macromolecular interaction perturbations in human genetic 
      disorders.
    findings: []
  - id: PMID:26320582
    title: Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate 
      via a Coupled Folding and Binding Mechanism.
    findings: []
  - id: PMID:27107014
    title: An inter-species protein-protein interaction network across vast 
      evolutionary distance.
    findings: []
  - id: PMID:27368102
    title: An ER-Associated Pathway Defines Endosomal Architecture for 
      Controlled Cargo Transport.
    findings: []
  - id: PMID:31263572
    title: Dominant TOM1 mutation associated with combined immunodeficiency and 
      autoimmune disease.
    findings: []
  - id: PMID:31515488
    title: Extensive disruption of protein interactions by genetic variants 
      across the allele frequency spectrum in human populations.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:34524948
    title: Global Proximity Interactome of the Human Macroautophagy Pathway.
    findings: []
  - id: PMID:35271311
    title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []
  - id: Reactome:R-HSA-446634
    title: IRAK4 is activated by autophosphorylation
    findings: []
  - id: Reactome:R-HSA-446684
    title: IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor 
      activation
    findings: []
  - id: Reactome:R-HSA-446692
    title: IRAK1 binds to MYD88 within the IL1R complex
    findings: []
  - id: Reactome:R-HSA-446694
    title: IRAK4 phosphorylates IRAK1
    findings: []
  - id: Reactome:R-HSA-446701
    title: IRAK4-activated IRAK1 autophosphorylates
    findings: []
  - id: Reactome:R-HSA-446862
    title: Hyperphosphorylated IRAK1 associates with TRAF6
    findings: []
  - id: Reactome:R-HSA-446868
    title: The Interleukin 1 receptor complex binds Tollip
    findings: []
  - id: Reactome:R-HSA-446894
    title: TRAF6 binding leads to IRAK1:TRAF6 release
    findings: []
  - id: Reactome:R-HSA-6798749
    title: Exocytosis of specific granule lumen proteins
    findings: []
  - id: Reactome:R-HSA-6798751
    title: Exocytosis of azurophil granule lumen proteins
    findings: []