Tumor suppressor p53 is a multifunctional transcription factor that acts as a guardian of the genome, coordinating cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress. It regulates cell fate decisions through transcriptional control of genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism. TP53 is the most frequently mutated gene in human cancers (~50%), underlining its critical role in preventing malignant transformation. Beyond its canonical tumor suppressive functions, p53 also regulates ferroptosis, autophagy, immune responses, and stemness.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000976 transcription cis-regulatory region binding | IEA GO_REF:0000002 | ACCEPT | Summary: TP53 is a well-established DNA-binding transcription factor that directly binds to p53 response elements in target gene promoters. This is one of its core molecular functions, supported by extensive experimental evidence including the IDA annotations from PMID:15710329 and PMID:17996705. Reason: This annotation accurately represents a core molecular function of p53. Multiple lines of experimental evidence confirm p53 directly binds cis-regulatory regions to regulate transcription. Supporting Evidence: PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription PMID:17996705 An acetylation switch in p53 mediates holo-TFIID recruitment file:human/TP53/TP53-deep-research-falcon.md model: Edison Scientific Literature |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes. Reason: Core function - transcriptional repression is part of p53's regulatory activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. PMID:19749791 Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. |
| GO:0000423 mitophagy | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 has complex roles in autophagy and mitophagy regulation, with both promoting and inhibiting functions depending on context. There is also a negative regulation of mitophagy annotation (GO:1901525), suggesting context-dependent regulation. Reason: p53 regulates mitophagy through multiple mechanisms including transcriptional control of mitophagy-related genes. This is part of its broader role in cellular stress response and metabolism. Supporting Evidence: file:human/TP53/TP53-uniprot.txt GO; GO:0006914; P:autophagy; IMP:CAFA file:human/TP53/TP53-deep-research-manual.md Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on |
| GO:0001701 in utero embryonic development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TP53 plays roles in embryonic development, though p53 knockout mice are viable, indicating it is not absolutely essential. Development-related functions are context-specific rather than core functions. Reason: While p53 has developmental roles, these are not its primary functions. p53-null mice can complete embryonic development, though with increased cancer susceptibility. Supporting Evidence: file:human/TP53/TP53-uniprot.txt GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl ... GO; GO:0048568; P:embryonic organ development; IEA:Ensembl file:human/TP53/TP53-deep-research-manual.md Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions and may represent over-annotation in certain contexts |
| GO:0001756 somitogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Somitogenesis is a specific developmental process. While p53 may influence developmental processes, this is a highly specific annotation that is not a core function. Reason: Very specific developmental process that is not central to p53 function. p53 knockout mice complete somitogenesis successfully. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Although p53 plays roles in development and embryogenesis, these are often secondary to its core tumor suppressor functions |
| GO:0001836 release of cytochrome c from mitochondria | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 promotes apoptosis through the mitochondrial pathway, including regulation of cytochrome c release via transcriptional targets like BAX and PUMA, as well as direct mitochondrial functions. Reason: Core component of p53-mediated intrinsic apoptotic pathway. p53 induces pro-apoptotic BCL2 family members that trigger cytochrome c release. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS); Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins |
| GO:0002309 T cell proliferation involved in immune response | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TP53 has emerging roles in immune regulation, but specific T cell proliferation is not a core function. This may relate to non-cell-autonomous tumor suppression through immune modulation. Reason: While p53 influences immune responses, direct regulation of T cell proliferation is not a primary function. This is a context-specific, non-core role. |
| GO:0002326 B cell lineage commitment | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: B cell lineage commitment is a specific hematopoietic developmental process. While p53 may influence hematopoiesis, this is not a core function. Reason: Highly specific developmental process in the immune system. Not a primary function of p53 as a tumor suppressor. |
| GO:0002360 T cell lineage commitment | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: T cell lineage commitment is a specific developmental process in hematopoiesis. Not a core p53 function. Reason: Specific immune system developmental process that is not central to p53 tumor suppressor function. |
| GO:0002931 response to ischemia | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 responds to hypoxic stress and ischemia as part of its cellular stress response functions. This involves HIF pathway interactions and metabolic regulation. Reason: Part of p53s broader cellular stress response function. Ischemia/hypoxia is a well-documented p53-activating stress signal. Supporting Evidence: GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia |
| GO:0006302 double-strand break repair | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 coordinates DNA damage response including regulation of DNA repair genes. It promotes both repair and apoptosis depending on damage severity. Reason: Core function of p53 as guardian of the genome. p53 regulates multiple DNA repair pathways through transcriptional control of repair genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest, DNA repair or apoptosis |
| GO:0006357 regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: p53 regulates RNA polymerase II transcription as both activator and repressor. Reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. |
| GO:0006606 protein import into nucleus | IEA GO_REF:0000107 | REMOVE | Summary: This likely refers to p53s own nuclear import rather than it regulating import of other proteins. p53 nuclear localization is critical for its function but this annotation is unclear. Reason: Ambiguous annotation - p53 undergoes nuclear import but does not regulate protein import into nucleus as a general function. This appears to be a misannotation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Nuclear Localization Signals (NLS): Location: Residues 305-322 and 369-375; Function: Nuclear import and localization [refers to p53s own import, not regulation of other proteins] |
| GO:0006974 DNA damage response | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0006979 response to oxidative stress | IEA GO_REF:0000120 | ACCEPT | Summary: TP53 is activated by oxidative stress and regulates antioxidant responses, ROS metabolism, and cell fate decisions under oxidative conditions. Reason: Core stress response function. p53 responds to oxidative stress and regulates redox balance through multiple target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TP53 has complex interactions with TGF-beta signaling, but this is not a core function. There is also annotation for negative regulation of this pathway (GO:0030512). Reason: While p53 interacts with TGF-beta signaling, this is a context-specific crosstalk rather than a core p53 function. |
| GO:0007346 regulation of mitotic cell cycle | IEA GO_REF:0000107 | ACCEPT | Summary: Cell cycle regulation is a fundamental function of TP53. It induces cell cycle arrest through p21/CDKN1A and other cell cycle regulators. Reason: Core tumor suppressor function. p53 induces cell cycle checkpoints in response to stress, preventing damaged cells from proliferating. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division by controlling expression of a set of genes required for this process |
| GO:0007369 gastrulation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Gastrulation is a specific early developmental process. p53 is not essential for gastrulation as p53-null mice complete this process. Reason: Highly specific developmental process that is not a core p53 function. p53 knockout mice undergo normal gastrulation. |
| GO:0007405 neuroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neuroblast proliferation is a specific neural developmental process. Not a core p53 function. Reason: Specific developmental process in nervous system. p53 may regulate proliferation broadly but neuroblast-specific regulation is not core. |
| GO:0007406 negative regulation of neuroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 negatively regulates proliferation broadly, but neuroblast-specific regulation is a specialized context. Reason: While p53 inhibits proliferation generally, neuroblast-specific regulation is not a core function but rather a tissue-specific manifestation. |
| GO:0007417 central nervous system development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: CNS development is a broad developmental process. p53 has roles but is not essential as p53-null mice have functional CNS. Reason: Developmental process that is not core to p53 tumor suppressor function. p53-null mice develop functional nervous systems. |
| GO:0007507 heart development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Heart development is a specific organ developmental process. Not essential as p53-null mice have normal hearts. Reason: Organ-specific developmental process that is not a core p53 function. p53 knockout mice develop normal hearts. |
| GO:0008156 negative regulation of DNA replication | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 inhibits DNA replication as part of cell cycle arrest, preventing replication of damaged DNA. Reason: Core function related to cell cycle control and preventing propagation of damaged DNA. Part of p53s tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division |
| GO:0008283 cell population proliferation | IEA GO_REF:0000107 | REMOVE | Summary: This is a very general term. p53 primarily NEGATIVELY regulates proliferation. The annotation GO:0008285 (negative regulation) is more accurate. Reason: Too general and potentially misleading. p53 primarily inhibits rather than promotes proliferation. The negative regulation annotation is more appropriate. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division by controlling expression of a set of genes required for this process |
| GO:0009303 rRNA transcription | IEA GO_REF:0000107 | ACCEPT | Summary: p53 can regulate ribosomal biogenesis and rRNA transcription as part of metabolic control, typically inhibiting it under stress. Reason: p53 regulates ribosome biogenesis and protein synthesis capacity, typically suppressing rRNA transcription under stress conditions. |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000120 | ACCEPT | Summary: TP53 responds to various xenobiotic stresses including drugs and toxins that cause DNA damage or cellular stress. Reason: Part of p53s broad stress response function. Many xenobiotics activate p53 through DNA damage or other stress pathways. |
| GO:0009411 response to UV | IEA GO_REF:0000120 | ACCEPT | Summary: UV radiation causes DNA damage that strongly activates p53. This is a well-characterized p53-activating stress. Reason: Core stress response function. UV-induced DNA damage is a classic p53 activator leading to repair, arrest, or apoptosis. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type |
| GO:0009651 response to salt stress | IEA GO_REF:0000107 | REMOVE | Summary: Salt stress response is not a well-characterized p53 function in mammalian cells. This may be an over-annotation. Reason: No strong evidence for salt stress as a p53-activating stimulus in mammalian cells. Likely computational over-annotation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network ... It integrates signals from upstream kinases (ATM, ATR, DNA-PK) [no mention of salt stress as an activating signal] |
| GO:0009792 embryo development ending in birth or egg hatching | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Very broad developmental term. p53-null mice are viable, so p53 is not essential for embryo development to birth. Reason: While p53 has developmental roles, it is not essential for embryo development to birth. This is a non-core function. |
| GO:0010165 response to X-ray | IEA GO_REF:0000107 | ACCEPT | Summary: X-ray radiation causes DNA damage that activates p53. Part of p53s DNA damage response function. Reason: Core function - ionizing radiation like X-rays cause DNA damage that strongly activates p53. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type |
| GO:0010332 response to gamma radiation | IEA GO_REF:0000107 | ACCEPT | Summary: p53 responds to gamma radiation-induced DNA damage. Reason: Core function - ionizing radiation strongly activates p53. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 responds to DNA damage from ionizing radiation PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0010629 negative regulation of gene expression | IEA GO_REF:0000107 | ACCEPT | Summary: TP53 functions as both activator and repressor of gene expression. It represses anti-apoptotic and proliferation genes. Reason: Core transcriptional function. p53 represses multiple genes including BCL2, survivin, and cell cycle genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt repression of Bcl-2 expression |
| GO:0010659 cardiac muscle cell apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific apoptosis. While p53 induces apoptosis broadly, cardiac-specific regulation is context-dependent. Reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but a specialized context. |
| GO:0010666 positive regulation of cardiac muscle cell apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Tissue-specific apoptotic regulation. p53 can induce apoptosis in cardiac cells but this is not a core function. Reason: Cell type-specific apoptotic function. The general apoptotic function is core, but cardiac-specific regulation is context-dependent. |
| GO:0014009 glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific proliferation. Not a core p53 function. Reason: Tissue-specific proliferation regulation in nervous system. Not central to p53 tumor suppressor function. |
| GO:0019661 homolactic fermentation | IEA GO_REF:0000107 | MODIFY | Summary: TP53 regulates glucose metabolism and suppresses glycolysis (Warburg effect). There is also annotation for negative regulation (GO:1904024). Reason: p53 primarily SUPPRESSES glycolysis/Warburg effect, not promotes it. The negative regulation annotation is more accurate. Proposed replacements: negative regulation of glucose catabolic process to lactate via pyruvate Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Wild-type p53: Inhibits glycolysis, promotes oxidative phosphorylation and mitochondrial respiration ... Specific targets: TIGAR (inhibits glycolysis), SCO2 (promotes oxidative phosphorylation) |
| GO:0021549 cerebellum development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Specific brain region development. Not essential as p53-null mice have functional cerebellum. Reason: Region-specific developmental process that is not core to p53 function. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 has complex crosstalk with TGF-beta signaling but this is not a core function. Reason: Context-specific signaling crosstalk rather than core p53 function. |
| GO:0031571 mitotic G1 DNA damage checkpoint signaling | IEA GO_REF:0000107 | ACCEPT | Summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction. Reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Cell cycle arrest is mediated by transcriptional upregulation of p21 PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0033077 T cell differentiation in thymus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Specific immune system developmental process. Not a core p53 function. Reason: Tissue-specific developmental process in immune system. Not central to p53 tumor suppressor function. |
| GO:0033554 cellular response to stress | IEA GO_REF:0000107 | ACCEPT | Summary: Broad term encompassing p53s fundamental role as a stress sensor and responder. Covers DNA damage, oxidative stress, hypoxia, etc. Reason: Core function - p53 is the master cellular stress response coordinator, responding to diverse stress signals. Supporting Evidence: PMID:14744935 The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis |
| GO:0034103 regulation of tissue remodeling | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Tissue remodeling is not a well-characterized p53 function. This appears to be an over-annotation. Reason: Not a core p53 function. May relate to indirect effects through apoptosis or senescence but not a primary role. |
| GO:0035264 multicellular organism growth | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Very broad developmental term. p53 influences growth through proliferation control but is not essential for organism growth. Reason: Broad developmental process. p53-null mice show normal growth patterns despite cancer susceptibility. |
| GO:0035794 positive regulation of mitochondrial membrane permeability | IEA GO_REF:0000107 | ACCEPT | Summary: p53 promotes mitochondrial outer membrane permeabilization during apoptosis through BAX/BAK activation. Core apoptotic function. Reason: Core component of p53-mediated intrinsic apoptosis. p53 target genes like BAX and PUMA promote MOMP. Supporting Evidence: GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO:0042127 regulation of cell population proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: General term for proliferation regulation. p53 primarily negatively regulates proliferation through cell cycle arrest. Reason: Core function - p53 is a key regulator of proliferation, primarily through negative regulation via cell cycle checkpoints. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division |
| GO:0043065 positive regulation of apoptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism. Reason: Core function - p53 induces apoptosis through multiple pathways. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0043066 negative regulation of apoptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival. Reason: Context-dependent function - p53 can promote survival under mild stress conditions. Supporting Evidence: PMID:14744935 We demonstrate that endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis |
| GO:0043504 mitochondrial DNA repair | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 has mitochondrial localization and can contribute to mitochondrial genome stability, though this is not a primary function. Reason: While p53 can localize to mitochondria and influence mtDNA stability, this is not a core tumor suppressor function. |
| GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 both executes and regulates its own DNA damage response pathway. This is a core function. Reason: Core function - p53 is the central regulator of its own pathway, with multiple feedback loops and regulatory mechanisms. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type |
| GO:0043523 regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific apoptotic regulation. p53 can regulate neuronal apoptosis but this is context-specific. Reason: Tissue-specific manifestation of p53s apoptotic function. Not a core function but relevant in neurodegeneration contexts. |
| GO:0043525 positive regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neuron-specific pro-apoptotic function. While p53 induces apoptosis broadly, neuron-specific regulation is context-dependent. Reason: Cell type-specific apoptotic function relevant in neurodegeneration but not a core p53 function. |
| GO:0045861 negative regulation of proteolysis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 can regulate proteolysis through various mechanisms including MDM2 regulation and proteasome activity, but this is not a primary function. Reason: While p53 influences protein stability and degradation pathways, negative regulation of proteolysis is not a core function. |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000120 | ACCEPT | Summary: p53 positively regulates DNA-templated transcription of target genes. Reason: Core transcriptional function - p53 activates transcription of numerous target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0045930 negative regulation of mitotic cell cycle | IEA GO_REF:0000107 | ACCEPT | Summary: Core function - p53 induces cell cycle arrest at multiple checkpoints to prevent proliferation of damaged cells. Reason: Fundamental tumor suppressor function. p53 arrests cell cycle through p21 and other CDK inhibitors. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division by controlling expression of a set of genes required for this process |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0048144 fibroblast proliferation | IEA GO_REF:0000107 | REMOVE | Summary: Cell type-specific proliferation. p53 generally inhibits rather than promotes proliferation. Reason: p53 primarily inhibits proliferation. This positive proliferation annotation appears incorrect. The negative regulation annotation (GO:0048147) is accurate. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division |
| GO:0048147 negative regulation of fibroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function. Reason: Cell type-specific manifestation of anti-proliferative function. |
| GO:0048568 embryonic organ development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Broad developmental term. p53 has developmental roles but is not essential for organ development. Reason: Developmental process that is not core to p53 function. p53-null mice develop functional organs. |
| GO:0050821 protein stabilization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 can stabilize some proteins through transcriptional targets or protein interactions, but this is not a primary function. Reason: Not a core p53 function. p53 itself is heavily regulated by stability but protein stabilization of other proteins is not primary. |
| GO:0051276 chromosome organization | IEA GO_REF:0000107 | REMOVE | Summary: Very broad term. p53 influences chromosome stability through DNA repair and checkpoints but does not directly organize chromosomes. Reason: Too broad and indirect. p53 maintains genome stability but chromosome organization per se is not its function. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network ... Cell cycle checkpoint activation; DNA repair pathway stimulation [maintains genome stability but not chromosome organization per se] |
| GO:0051402 neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Neuron-specific apoptosis. While p53 can induce neuronal apoptosis, this is context-specific. Reason: Cell type-specific apoptotic process. Relevant in neurodegeneration but not a core p53 function. |
| GO:0051726 regulation of cell cycle | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0060253 negative regulation of glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific anti-proliferative function in nervous system. Reason: Tissue-specific manifestation of p53s anti-proliferative function. Not a core function. |
| GO:0060411 cardiac septum morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Very specific cardiac developmental process. Not a core p53 function. Reason: Highly specific developmental process. p53-null mice have normal cardiac development. |
| GO:0070242 thymocyte apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific apoptosis in immune system development. Reason: Tissue-specific apoptotic process in immune system. Not a core p53 function. |
| GO:0070243 regulation of thymocyte apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Immune cell-specific apoptotic regulation during T cell development. Reason: Tissue-specific process in immune system development. Not a core p53 function. |
| GO:0070266 necroptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 has emerging roles in regulating necroptosis, a form of programmed necrosis, though apoptosis is its primary death pathway. Reason: Emerging function of p53 in non-apoptotic cell death. p53 can regulate necroptosis through various mechanisms. |
| GO:0071480 cellular response to gamma radiation | IEA GO_REF:0000107 | ACCEPT | Summary: p53 responds to gamma radiation-induced DNA damage. Reason: Core function - ionizing radiation is a classic p53 activator. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md gamma radiation causes DNA damage that strongly activates p53 PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0071494 cellular response to UV-C | IEA GO_REF:0000107 | ACCEPT | Summary: UV-C radiation causes severe DNA damage that activates p53. Part of DNA damage response. Reason: Core function - UV-C induces DNA lesions that strongly activate p53-mediated responses. Supporting Evidence: GO:0009411 response to UV |
| GO:0072089 stem cell proliferation | IEA GO_REF:0000107 | REMOVE | Summary: p53 generally suppresses rather than promotes proliferation, including in stem cells. Reason: p53 typically inhibits stem cell proliferation to maintain genomic stability. The negative regulation annotation (GO:2000647) is more accurate. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division by controlling expression of a set of genes required for this process |
| GO:0072331 signal transduction by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 IS the p53 class mediator that transduces signals in response to stress. Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation. Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. |
| GO:0072593 reactive oxygen species metabolic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 regulates ROS through multiple mechanisms including antioxidant genes and metabolic regulation. Important for redox balance. Reason: Important function - p53 regulates cellular redox state through multiple target genes affecting ROS production and scavenging. Supporting Evidence: GO:2000378 negative regulation of reactive oxygen species metabolic process |
| GO:1901525 negative regulation of mitophagy | IEA GO_REF:0000107 | ACCEPT | Summary: p53 has complex bidirectional effects on autophagy/mitophagy - can both promote and inhibit depending on context. Reason: p53 can negatively regulate mitophagy in certain contexts while promoting it in others. This dual role is well-documented. |
| GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: Core apoptotic function - p53 regulates mitochondrial outer membrane permeabilization through BAX/BAK activation. Reason: Core function in intrinsic apoptosis. p53 target genes like BAX and PUMA promote mitochondrial membrane permeabilization. Supporting Evidence: GO:0035794 positive regulation of mitochondrial membrane permeability |
| GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 both executes and regulates its own intrinsic apoptotic pathway. Core function. Reason: Core function - p53 is the master regulator of its own apoptotic pathway with multiple feedback mechanisms. Supporting Evidence: GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:1903799 negative regulation of miRNA processing | IEA GO_REF:0000107 | ACCEPT | Summary: p53 has complex effects on miRNA processing - can both promote and inhibit. There is also positive regulation annotation (GO:1902895). Reason: p53 regulates miRNA processing through interaction with Drosha complex and other mechanisms. Can have both positive and negative effects. |
| GO:1904024 negative regulation of glucose catabolic process to lactate via pyruvate | IEA GO_REF:0000107 | ACCEPT | Summary: p53 suppresses glycolysis/Warburg effect as part of its metabolic regulatory and tumor suppressor functions. Reason: Important metabolic function - p53 suppresses aerobic glycolysis (Warburg effect) that is characteristic of cancer cells. Supporting Evidence: file:human/TP53/TP53-uniprot.txt GO; GO:0019661; P:glucose catabolic process to lactate via pyruvate; IEA:Ensembl ... GO; GO:1904024; P:negative regulation of glucose catabolic process to lactate via pyruvate; IEA:Ensembl |
| GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia | IEA GO_REF:0000107 | ACCEPT | Summary: p53 mediates apoptosis in response to severe hypoxia. Part of its stress response repertoire. Reason: Core stress response function - p53 induces apoptosis under severe hypoxic stress through HIF interactions and target genes. Supporting Evidence: GO:0002931 response to ischemia |
| GO:2000269 regulation of fibroblast apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell type-specific apoptotic regulation in fibroblasts. Reason: Tissue-specific apoptotic function. The general apoptotic function is core, but fibroblast-specific regulation is context-dependent. |
| GO:2000378 negative regulation of reactive oxygen species metabolic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 regulates cellular redox balance and can suppress ROS through antioxidant gene expression. Reason: Important function - p53 maintains redox homeostasis by inducing antioxidant genes like GPX1, SOD2, and others. Supporting Evidence: GO:0072593 reactive oxygen species metabolic process |
| GO:2000647 negative regulation of stem cell proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: p53 maintains stem cell genomic stability by limiting proliferation. Important for preventing cancer stem cells. Reason: Important function - p53 restricts stem cell self-renewal to maintain genomic integrity and prevent transformation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces growth arrest or apoptosis depending on the physiological circumstances and cell type ... Negatively regulates cell division by controlling expression of a set of genes required for this process |
| GO:2000772 regulation of cellular senescence | IEA GO_REF:0000107 | ACCEPT | Summary: Senescence induction is a core p53 tumor suppressor mechanism, alternative to apoptosis for preventing damaged cell proliferation. Reason: Core function - p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence ... Negatively regulates cell division |
| GO:0160020 positive regulation of ferroptosis | TAS file:human/TP53/TP53-deep-research.md | NEW | Summary: p53 promotes ferroptosis through multiple mechanisms including repression of SLC7A11 (cystine/glutamate antiporter), activation of ALOX12, and promotion of lipid peroxidation. This is an important non-apoptotic cell death mechanism. Reason: Ferroptosis regulation is a well-established p53 function documented in recent literature but missing from current GO annotations. p53 acts as a positive regulator of ferroptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Pro-ferroptotic: Represses SLC7A11, activates ALOX12, promotes lipid peroxidation file:human/TP53/TP53-deep-research-manual.md p53 has a dual role in ferroptosis (iron-dependent programmed cell death) ... p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 |
| GO:1902895 positive regulation of miRNA transcription | IMP PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... | ACCEPT | Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family. Reason: p53 regulates miRNA expression as part of its stress response functions. Supporting Evidence: PMID:30089260 we only observed significant Dox dose- and time-dependent increases in the expression levels of miR-103 and miR-107... we found p53-dependent induction of these miRNAs upon nutlin-3a treatment PMID:30089260 Using our CRISPR p53KO HCT116 cell lines, we found p53-dependent induction of these miRNAs upon nutlin-3a treatment |
| GO:0008285 negative regulation of cell population proliferation | ISS PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading... | ACCEPT | Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism. Reason: Core function - p53 inhibits proliferation through cell cycle arrest. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. |
| GO:0051726 regulation of cell cycle | ISS PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading... | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:1902749 regulation of cell cycle G2/M phase transition | IMP PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of norm... | ACCEPT | Summary: p53 regulates the G2/M checkpoint, preventing mitosis of damaged cells. Core cell cycle control function. Reason: Core cell cycle checkpoint function with experimental evidence. p53 induces G2 arrest through multiple mechanisms. Supporting Evidence: PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in ... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0000976 transcription cis-regulatory region binding | IDA PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... | ACCEPT | Summary: Direct experimental evidence for p53 DNA binding activity. Core molecular function with IDA support. Reason: Core molecular function with direct experimental evidence of p53 binding to cis-regulatory regions. Supporting Evidence: PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associ... | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0006974 DNA damage response | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0006983 ER overload response | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 responds to ER stress. The cited paper shows ER stress affects p53 localization and function. Reason: p53 responds to ER stress as part of its cellular stress response repertoire. Supported by experimental evidence. Supporting Evidence: PMID:14744935 endoplasmic reticulum (ER) stress inhibits p53-mediated apoptosis... ER stress induces GSK-3beta binding to p53 |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0042981 regulation of apoptotic process | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes. Reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. |
| GO:0016604 nuclear body | IDA PMID:10360174 Mutations in human ARF exon 2 disrupt its nucleolar localiza... | ACCEPT | Summary: p53 localizes to nuclear bodies including PML bodies and nucleoli under certain conditions. This is related to its regulatory functions. Reason: p53 localizes to nuclear bodies like PML bodies, especially during stress responses and senescence. This subcellular localization is functionally relevant. Supporting Evidence: PMID:10360174 ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 |
| GO:0000976 transcription cis-regulatory region binding | IDA PMID:17996705 An acetylation switch in p53 mediates holo-TFIID recruitment... | ACCEPT | Summary: Additional IDA evidence for p53 DNA binding. Duplicate annotation with different experimental support. Reason: Core molecular function with direct experimental evidence. p53 binds to consensus sequences in target gene promoters. Supporting Evidence: PMID:17996705 An acetylation switch in p53 mediates holo-TFIID recruitment |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:17599062 CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediate... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0042149 cellular response to glucose starvation | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 responds to glucose starvation as part of metabolic stress response. Reason: p53 responds to metabolic stress including glucose deprivation. Supporting Evidence: PMID:14744935 The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational mechanisms to induce cell-cycle arrest, senescence, or apoptosis |
| GO:0001666 response to hypoxia | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is activated by hypoxic stress and mediates cellular responses to low oxygen through HIF pathway interactions. Reason: Core stress response function. Hypoxia is a well-established p53-activating stress that leads to cell cycle arrest or apoptosis depending on severity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals including DNA damage, oxidative stress, hypoxia, and metabolic stress |
| GO:0000785 chromatin | IBA GO_REF:0000033 | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IBA GO_REF:0000033 | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0042981 regulation of apoptotic process | IBA GO_REF:0000033 | ACCEPT | Summary: p53 is a master regulator of apoptosis, both promoting and (in some contexts) inhibiting apoptotic processes. Reason: Core function - p53 regulates apoptosis through multiple mechanisms including transcriptional activation of pro-apoptotic genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:1990841 promoter-specific chromatin binding | IBA GO_REF:0000033 | ACCEPT | Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements. Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding. Supporting Evidence: PDB:3TS8 Crystal structure shows p53 binding to CDKN1A(p21) promoter response element PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20725088 2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IBA GO_REF:0000033 | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes. Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. |
| GO:0003677 DNA binding | IEA GO_REF:0000120 | ACCEPT | Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements. Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops PMID:15358771 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:2144364 Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. |
| GO:0003700 DNA-binding transcription factor activity | IEA GO_REF:0000120 | ACCEPT | Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes. Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005759 mitochondrial matrix | IEA GO_REF:0000120 | ACCEPT | Summary: p53 localizes to mitochondria where it can directly promote apoptosis through non-transcriptional mechanisms. Reason: Important cellular localization - p53 can translocate to mitochondria and directly trigger apoptosis through BAX/BAK activation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000044 | ACCEPT | Summary: p53 localizes to endoplasmic reticulum where it responds to ER stress. Reason: p53 responds to ER stress signals and can localize to ER during stress responses. Supporting Evidence: PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization |
| GO:0005813 centrosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: p53 has been reported to localize to centrosomes but this is not a primary localization. Reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function. |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000120 | ACCEPT | Summary: p53 regulates DNA-templated transcription as both an activator and repressor. Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0006915 apoptotic process | IEA GO_REF:0000120 | ACCEPT | Summary: p53 is a master regulator of apoptosis, inducing cell death through multiple pathways. Reason: Core function - apoptosis induction is one of p53's primary tumor suppressor mechanisms. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces growth arrest or apoptosis depending on the physiological circumstances |
| GO:0010212 response to ionizing radiation | IEA GO_REF:0000117 | ACCEPT | Summary: p53 is strongly activated by ionizing radiation-induced DNA damage. Reason: Core function - ionizing radiation is a classic p53-activating stress through ATM/ATR signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network |
| GO:0012501 programmed cell death | IEA GO_REF:0000043 | ACCEPT | Summary: p53 induces programmed cell death through apoptosis, and also regulates other cell death pathways. Reason: Core function - p53 is a master regulator of programmed cell death. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces growth arrest or apoptosis |
| GO:0016605 PML body | IEA GO_REF:0000044 | ACCEPT | Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation. Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 localizes to nuclear bodies like PML bodies, especially during stress responses PMID:22869143 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | ACCEPT | Summary: p53's DNA-binding domain contains a zinc coordination site essential for structural stability. Reason: Core structural feature - the p53 DNA-binding domain contains a zinc atom coordinated by Cys176, His179, Cys238, and Cys242. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Contains zinc coordination site in DNA-binding domain |
| GO:0048511 rhythmic process | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: p53 may influence circadian rhythms but this is not a core function. Reason: Non-core function. p53 has connections to circadian biology but this is not its primary role. |
| GO:0051053 negative regulation of DNA metabolic process | IEA GO_REF:0000117 | ACCEPT | Summary: p53 negatively regulates DNA replication as part of cell cycle arrest response. Reason: Core function related to cell cycle control - p53 inhibits DNA replication in damaged cells. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division |
| GO:0051262 protein tetramerization | IEA GO_REF:0000002 | ACCEPT | Summary: p53 forms tetramers through its oligomerization domain (residues 325-356), essential for DNA binding. Reason: Core structural feature - tetramerization is essential for high-affinity DNA binding and p53 function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain shows dimer-of-dimers architecture |
| GO:0071456 cellular response to hypoxia | IEA GO_REF:0000117 | ACCEPT | Summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction. Reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses. Supporting Evidence: GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. |
| GO:0097190 apoptotic signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: p53 is a master regulator of apoptotic signaling pathways. Reason: Core function - p53 activates both intrinsic and extrinsic apoptotic signaling. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression |
| GO:2001242 regulation of intrinsic apoptotic signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: p53 both executes and regulates the intrinsic apoptotic signaling pathway. Reason: Core function - p53 is a key regulator of intrinsic apoptotic signaling through multiple target genes. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 triggers apoptosis through both transcription-dependent and transcription-independent mechanisms |
| GO:0005515 protein binding | IPI PMID:10196247 Characterization of an E1A-CBP interaction defines a novel t... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10196247 Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300. |
| GO:0005515 protein binding | IPI PMID:10226625 The yeast two-hybrid system reveals no interaction between p... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10226625 The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen. |
| GO:0005515 protein binding | IPI PMID:10518217 A novel cofactor for p300 that regulates the p53 response. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10518217 A novel cofactor for p300 that regulates the p53 response. |
| GO:0005515 protein binding | IPI PMID:10823891 The Huntington's disease protein interacts with p53 and CREB... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10823891 The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. |
| GO:0005515 protein binding | IPI PMID:11146555 Functional interaction between p53 and the interferon-induci... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11146555 Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. |
| GO:0005515 protein binding | IPI PMID:11178989 MDM2 enhances the function of estrogen receptor alpha in hum... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11178989 MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. |
| GO:0005515 protein binding | IPI PMID:11359905 The corepressor mSin3a interacts with the proline-rich domai... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11359905 The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation. |
| GO:0005515 protein binding | IPI PMID:11388671 A putative protein inhibitor of activated STAT (PIASy) inter... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11388671 A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. |
| GO:0005515 protein binding | IPI PMID:11427532 p53 Modulates the exonuclease activity of Werner syndrome pr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11427532 2001 Jun 26. p53 Modulates the exonuclease activity of Werner syndrome protein. |
| GO:0005515 protein binding | IPI PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. |
| GO:0005515 protein binding | IPI PMID:11706030 Differential effect of ik3-1/cables on p53- and p73-induced ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11706030 Nov 12. Differential effect of ik3-1/cables on p53- and p73-induced cell death. |
| GO:0005515 protein binding | IPI PMID:11877378 Structure of the 53BP1 BRCT region bound to p53 and its comp... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11877378 Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. |
| GO:0005515 protein binding | IPI PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
| GO:0005515 protein binding | IPI PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12080348 Nucleophosmin regulates the stability and transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:12620801 Requirement of E6AP and the features of human papillomavirus... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12620801 Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. |
| GO:0005515 protein binding | IPI PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
| GO:0005515 protein binding | IPI PMID:12692135 P63 alpha mutations lead to aberrant splicing of keratinocyt... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12692135 2003 Apr 10. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. |
| GO:0005515 protein binding | IPI PMID:12702766 Characterization of cells and gene-targeted mice deficient f... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12702766 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). |
| GO:0005515 protein binding | IPI PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. |
| GO:0005515 protein binding | IPI PMID:14557665 Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and e... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14557665 Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx. |
| GO:0005515 protein binding | IPI PMID:14627987 PARP-1 binds E2F-1 independently of its DNA binding and cata... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14627987 PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase. |
| GO:0005515 protein binding | IPI PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. |
| GO:0005515 protein binding | IPI PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. |
| GO:0005515 protein binding | IPI PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005515 protein binding | IPI PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. |
| GO:0005515 protein binding | IPI PMID:15044383 Aprataxin, a novel protein that protects against genotoxic s... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15044383 Mar 25. Aprataxin, a novel protein that protects against genotoxic stress. |
| GO:0005515 protein binding | IPI PMID:15068796 C. elegans SGK-1 is the critical component in the Akt/PKB ki... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15068796 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. |
| GO:0005515 protein binding | IPI PMID:15133049 NMR structure of the N-terminal domain of SUMO ligase PIAS1 ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15133049 2004 May 8. NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. |
| GO:0005515 protein binding | IPI PMID:15144954 Nucleolar protein NPM interacts with HDM2 and protects tumor... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15144954 Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. |
| GO:0005515 protein binding | IPI PMID:15205477 Calorie restriction promotes mammalian cell survival by indu... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15205477 Jun 17. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. |
| GO:0005515 protein binding | IPI PMID:15310821 Identification of ASK and clock-associated proteins as molec... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15310821 Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis. |
| GO:0005515 protein binding | IPI PMID:15364927 Negative regulation of p53 functions by Daxx and the involve... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15364927 2004 Sep 10. Negative regulation of p53 functions by Daxx and the involvement of MDM2. |
| GO:0005515 protein binding | IPI PMID:15525938 Regulation of p53 activity through lysine methylation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15525938 Regulation of p53 activity through lysine methylation. |
| GO:0005515 protein binding | IPI PMID:15542844 p53 Stabilization and accumulation induced by human vaccinia... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15542844 p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. |
| GO:0005515 protein binding | IPI PMID:15580310 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and W... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15580310 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. |
| GO:0005515 protein binding | IPI PMID:15604276 Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p5... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15604276 Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. |
| GO:0005515 protein binding | IPI PMID:15660129 The DEAD box protein p68: a novel transcriptional coactivato... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15660129 The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. |
| GO:0005515 protein binding | IPI PMID:15735006 p53 modulates RPA-dependent and RPA-independent WRN helicase... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15735006 p53 modulates RPA-dependent and RPA-independent WRN helicase activity. |
| GO:0005515 protein binding | IPI PMID:15782130 BARD1 induces apoptosis by catalysing phosphorylation of p53... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15782130 BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. |
| GO:0005515 protein binding | IPI PMID:15855171 Direct interaction of the N-terminal domain of focal adhesio... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15855171 2005 Apr 25. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. |
| GO:0005515 protein binding | IPI PMID:15916963 Loss of HAUSP-mediated deubiquitination contributes to DNA d... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15916963 Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. |
| GO:0005515 protein binding | IPI PMID:15960975 Physical association and coordinate function of the H3 K4 me... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15960975 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. |
| GO:0005515 protein binding | IPI PMID:15989956 ARF-BP1/Mule is a critical mediator of the ARF tumor suppres... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15989956 ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. |
| GO:0005515 protein binding | IPI PMID:16003391 AtBAG6, a novel calmodulin-binding protein, induces programm... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16003391 AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants. |
| GO:0005515 protein binding | IPI PMID:16151013 PUMA couples the nuclear and cytoplasmic proapoptotic functi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16151013 PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. |
| GO:0005515 protein binding | IPI PMID:16169070 A human protein-protein interaction network: a resource for ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16169070 A human protein-protein interaction network: a resource for annotating the proteome. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16189514 Towards a proteome-scale map of the human protein-protein interaction network. |
| GO:0005515 protein binding | IPI PMID:16227626 Physical interaction and mutual transrepression between CCAA... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16227626 Oct 14. Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor. |
| GO:0005515 protein binding | IPI PMID:16319068 Camptothecin induces nuclear export of prohibitin preferenti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16319068 Nov 30. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. |
| GO:0005515 protein binding | IPI PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:16376338 Protein kinase A phosphorylates and regulates dimerization o... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16376338 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. |
| GO:0005515 protein binding | IPI PMID:16376884 Characterisation of the interface between nucleophosmin (NPM... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16376884 2005 Dec 19. Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation. |
| GO:0005515 protein binding | IPI PMID:16377624 Protein kinase C delta regulates Ser46 phosphorylation of p5... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16377624 Dec 23. Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:16402859 Structural basis of competitive recognition of p53 and MDM2 ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16402859 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. |
| GO:0005515 protein binding | IPI PMID:16415881 Structural basis for the methylation site specificity of SET... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16415881 Jan 15. Structural basis for the methylation site specificity of SET7/9. |
| GO:0005515 protein binding | IPI PMID:16432196 The central region of HDM2 provides a second binding site fo... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16432196 The central region of HDM2 provides a second binding site for p53. |
| GO:0005515 protein binding | IPI PMID:16442532 Interaction of metallothionein with tumor suppressor p53 pro... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16442532 2006 Jan 20. Interaction of metallothionein with tumor suppressor p53 protein. |
| GO:0005515 protein binding | IPI PMID:16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16474402 Feb 12. Molecular recognition of p53 and MDM2 by USP7/HAUSP. |
| GO:0005515 protein binding | IPI PMID:16493710 Surface plasmon resonance imaging protein arrays for analysi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16493710 Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53. |
| GO:0005515 protein binding | IPI PMID:16511572 14-3-3gamma binds to MDMX that is phosphorylated by UV-activ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16511572 Mar 2. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. |
| GO:0005515 protein binding | IPI PMID:16601686 Tip60 and p400 are both required for UV-induced apoptosis bu... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16601686 Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. |
| GO:0005515 protein binding | IPI PMID:16611888 Targeting of p300/CREB binding protein coactivators by simia... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16611888 Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. |
| GO:0005515 protein binding | IPI PMID:16616141 Evidence that low doses of Taxol enhance the functional tran... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16616141 Epub 2006 Mar 29. Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells. |
| GO:0005515 protein binding | IPI PMID:16690937 NS3 protein of Hepatitis C virus associates with the tumour ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16690937 NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. |
| GO:0005515 protein binding | IPI PMID:16713569 A protein-protein interaction network for human inherited at... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16713569 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |
| GO:0005515 protein binding | IPI PMID:16732283 Lysine activation and functional analysis of E2-mediated con... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16732283 May 28. Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. |
| GO:0005515 protein binding | IPI PMID:16753148 Polo-like kinase 1 regulates mitotic arrest after UV irradia... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16753148 Epub 2006 May 30. Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation. |
| GO:0005515 protein binding | IPI PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interac... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. |
| GO:0005515 protein binding | IPI PMID:16845383 Critical role for Daxx in regulating Mdm2. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16845383 Critical role for Daxx in regulating Mdm2. |
| GO:0005515 protein binding | IPI PMID:16847267 MAGE-A tumor antigens target p53 transactivation function th... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16847267 MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |
| GO:0005515 protein binding | IPI PMID:16951253 Crystal structure of SV40 large T-antigen bound to p53: inte... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16951253 Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. |
| GO:0005515 protein binding | IPI PMID:16959611 Gain of function of mutant p53: the mutant p53/NF-Y protein ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16959611 Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. |
| GO:0005515 protein binding | IPI PMID:17080083 Inactivation of the p53 pathway in retinoblastoma. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17080083 Inactivation of the p53 pathway in retinoblastoma. |
| GO:0005515 protein binding | IPI PMID:17098746 FBXO11 promotes the Neddylation of p53 and inhibits its tran... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17098746 2006 Nov 9. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. |
| GO:0005515 protein binding | IPI PMID:17108971 Repression of p53 activity by Smyd2-mediated methylation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17108971 Repression of p53 activity by Smyd2-mediated methylation. |
| GO:0005515 protein binding | IPI PMID:17139261 p53 mediates the negative regulation of MDM2 by orphan recep... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17139261 Nov 30. p53 mediates the negative regulation of MDM2 by orphan receptor TR3. |
| GO:0005515 protein binding | IPI PMID:17159902 An essential function of the extreme C-terminus of MDM2 can ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17159902 An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. |
| GO:0005515 protein binding | IPI PMID:17170702 Cytoplasmic destruction of p53 by the endoplasmic reticulum-... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17170702 Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. |
| GO:0005515 protein binding | IPI PMID:17184779 Identification of differential proteins in nasopharyngeal ca... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17184779 2006 Dec 13. Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. |
| GO:0005515 protein binding | IPI PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA d... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. |
| GO:0005515 protein binding | IPI PMID:17254968 PRAK is essential for ras-induced senescence and tumor suppr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17254968 PRAK is essential for ras-induced senescence and tumor suppression. |
| GO:0005515 protein binding | IPI PMID:17268548 Monoubiquitylation promotes mitochondrial p53 translocation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17268548 Monoubiquitylation promotes mitochondrial p53 translocation. |
| GO:0005515 protein binding | IPI PMID:17274640 A limited screen for protein interactions reveals new roles ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17274640 A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. |
| GO:0005515 protein binding | IPI PMID:17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17290220 The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. |
| GO:0005515 protein binding | IPI PMID:17298945 The conserved CPH domains of Cul7 and PARC are protein-prote... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17298945 2007 Feb 12. The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. |
| GO:0005515 protein binding | IPI PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. |
| GO:0005515 protein binding | IPI PMID:17347673 Stra13 is induced by genotoxic stress and regulates ionizing... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17347673 Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. |
| GO:0005515 protein binding | IPI PMID:17438265 Four domains of p300 each bind tightly to a sequence spannin... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17438265 Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. |
| GO:0005515 protein binding | IPI PMID:17470788 PACT is a negative regulator of p53 and essential for cell g... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17470788 PACT is a negative regulator of p53 and essential for cell growth and embryonic development. |
| GO:0005515 protein binding | IPI PMID:17482142 Attenuation of DNA damage checkpoint by PBK, a novel mitotic... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17482142 Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. |
| GO:0005515 protein binding | IPI PMID:17568776 Phosphorylation of Pirh2 by calmodulin-dependent kinase II i... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17568776 Jun 14. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. |
| GO:0005515 protein binding | IPI PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to de... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. |
| GO:0005515 protein binding | IPI PMID:17662718 Protein-protein interactions among human lens acidic and bas... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17662718 Epub 2007 Jul 23. Protein-protein interactions among human lens acidic and basic beta-crystallins. |
| GO:0005515 protein binding | IPI PMID:17719542 hCAS/CSE1L associates with chromatin and regulates expressio... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17719542 hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. |
| GO:0005515 protein binding | IPI PMID:17805299 p53 is regulated by the lysine demethylase LSD1. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0005515 protein binding | IPI PMID:17875722 Efficient p53 activation and apoptosis by simultaneous disru... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17875722 Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. |
| GO:0005515 protein binding | IPI PMID:17906639 The prolyl isomerase Pin1 orchestrates p53 acetylation and d... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17906639 Sep 30. The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. |
| GO:0005515 protein binding | IPI PMID:17964266 Active regulator of SIRT1 cooperates with SIRT1 and facilita... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17964266 Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. |
| GO:0005515 protein binding | IPI PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. |
| GO:0005515 protein binding | IPI PMID:18172499 NUMB controls p53 tumour suppressor activity. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18172499 NUMB controls p53 tumour suppressor activity. |
| GO:0005515 protein binding | IPI PMID:18230339 Activation of p53-dependent responses in tumor cells treated... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18230339 Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide. |
| GO:0005515 protein binding | IPI PMID:18235501 DBC1 is a negative regulator of SIRT1. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18235501 DBC1 is a negative regulator of SIRT1. |
| GO:0005515 protein binding | IPI PMID:18235502 Negative regulation of the deacetylase SIRT1 by DBC1. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18235502 Negative regulation of the deacetylase SIRT1 by DBC1. |
| GO:0005515 protein binding | IPI PMID:18275817 Biochemical and structural studies of ASPP proteins reveal d... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18275817 Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. |
| GO:0005515 protein binding | IPI PMID:18309296 Proteasome activator PA28 gamma regulates p53 by enhancing i... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18309296 Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. |
| GO:0005515 protein binding | IPI PMID:18316739 Temporal activation of p53 by a specific MDM2 inhibitor is s... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18316739 Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. |
| GO:0005515 protein binding | IPI PMID:18354501 Structural insight into the TFIIE-TFIIH interaction: TFIIE a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18354501 Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH. |
| GO:0005515 protein binding | IPI PMID:18388957 NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal de... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18388957 NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b). |
| GO:0005515 protein binding | IPI PMID:18391200 Structure of tumor suppressor p53 and its intrinsically diso... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18391200 Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. |
| GO:0005515 protein binding | IPI PMID:18485870 Acetylation is indispensable for p53 activation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18485870 Acetylation is indispensable for p53 activation. |
| GO:0005515 protein binding | IPI PMID:18504427 Twist and p53 reciprocally regulate target genes via direct ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18504427 Twist and p53 reciprocally regulate target genes via direct interaction. |
| GO:0005515 protein binding | IPI PMID:18510931 Ectodermal factor restricts mesoderm differentiation by inhi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18510931 Ectodermal factor restricts mesoderm differentiation by inhibiting p53. |
| GO:0005515 protein binding | IPI PMID:18566590 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitinat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18566590 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. |
| GO:0005515 protein binding | IPI PMID:18624398 Protein interaction data set highlighted with human Ras-MAPK... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18624398 Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. |
| GO:0005515 protein binding | IPI PMID:18656471 Microtubule-associated protein 1B light chain (MAP1B-LC1) ne... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18656471 Epub 2008 Jul 24. Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells. |
| GO:0005515 protein binding | IPI PMID:18695251 AIMP2/p38, the scaffold for the multi-tRNA synthetase comple... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18695251 AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. |
| GO:0005515 protein binding | IPI PMID:18812399 14-3-3 activation of DNA binding of p53 by enhancing its ass... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18812399 Sep 23. 14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers. |
| GO:0005515 protein binding | IPI PMID:18952844 Inhibition of Thr-55 phosphorylation restores p53 nuclear lo... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18952844 Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. |
| GO:0005515 protein binding | IPI PMID:18977328 Inactivation of the CYLD deubiquitinase by HPV E6 mediates h... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18977328 Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. |
| GO:0005515 protein binding | IPI PMID:19008854 Interferon-inducible protein, P56, inhibits HPV DNA replicat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19008854 Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. |
| GO:0005515 protein binding | IPI PMID:19043414 Molecular basis of Pirh2-mediated p53 ubiquitylation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19043414 2008 Nov 30. Molecular basis of Pirh2-mediated p53 ubiquitylation. |
| GO:0005515 protein binding | IPI PMID:19098711 RYBP stabilizes p53 by modulating MDM2. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19098711 RYBP stabilizes p53 by modulating MDM2. |
| GO:0005515 protein binding | IPI PMID:19166840 FKBP25, a novel regulator of the p53 pathway, induces the de... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19166840 2009 Jan 21. FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53. |
| GO:0005515 protein binding | IPI PMID:19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. |
| GO:0005515 protein binding | IPI PMID:19217391 Structural basis for p300 Taz2-p53 TAD1 binding and modulati... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19217391 Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. |
| GO:0005515 protein binding | IPI PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabiliz... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. |
| GO:0005515 protein binding | IPI PMID:19255450 Structural basis for high-affinity peptide inhibition of p53... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19255450 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. |
| GO:0005515 protein binding | IPI PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. |
| GO:0005515 protein binding | IPI PMID:19345189 A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-ind... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19345189 A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. |
| GO:0005515 protein binding | IPI PMID:19411066 Regulation of XIAP translation and induction by MDM2 followi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19411066 Regulation of XIAP translation and induction by MDM2 following irradiation. |
| GO:0005515 protein binding | IPI PMID:19433796 A tumor suppressive coactivator complex of p53 containing AS... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19433796 A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. |
| GO:0005515 protein binding | IPI PMID:19508870 TOE1 interacts with p53 to modulate its transactivation pote... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19508870 Epub 2009 Jun 7. TOE1 interacts with p53 to modulate its transactivation potential. |
| GO:0005515 protein binding | IPI PMID:19521340 MDM4 (MDMX) localizes at the mitochondria and facilitates th... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19521340 MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. |
| GO:0005515 protein binding | IPI PMID:19536131 Differential regulation of p53 and p21 by MKRN1 E3 ligase co... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19536131 Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. |
| GO:0005515 protein binding | IPI PMID:19556538 Trim24 targets endogenous p53 for degradation. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19556538 Trim24 targets endogenous p53 for degradation. |
| GO:0005515 protein binding | IPI PMID:19619542 Mdmx enhances p53 ubiquitination by altering the substrate p... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19619542 2009 Jul 18. Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase. |
| GO:0005515 protein binding | IPI PMID:19626115 Modulation of microRNA processing by p53. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19626115 Modulation of microRNA processing by p53. |
| GO:0005515 protein binding | IPI PMID:19651603 Structural basis for subversion of cellular control mechanis... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19651603 Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. |
| GO:0005515 protein binding | IPI PMID:19656744 Ribosomal protein S3: A multi-functional protein that intera... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19656744 Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain. |
| GO:0005515 protein binding | IPI PMID:19680552 CK2 is the regulator of SIRT1 substrate-binding affinity, de... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19680552 CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. |
| GO:0005515 protein binding | IPI PMID:19684601 A molecular basis for phosphorylation-dependent SUMO conjuga... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19684601 Aug 16. A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. |
| GO:0005515 protein binding | IPI PMID:19740107 Epidermal growth factor receptor ligands as new extracellula... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19740107 2009 Sep 9. Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein. |
| GO:0005515 protein binding | IPI PMID:19798103 Efficient protection and isolation of ubiquitylated proteins... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19798103 Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities. |
| GO:0005515 protein binding | IPI PMID:19805293 CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p5... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19805293 CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. |
| GO:0005515 protein binding | IPI PMID:19833129 Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimula... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19833129 Epub 2009 Oct 13. Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover. |
| GO:0005515 protein binding | IPI PMID:19857493 Role of p53/FAK association and p53Ser46 phosphorylation in ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19857493 Epub 2009 Oct 24. Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H. |
| GO:0005515 protein binding | IPI PMID:19933256 Mechanistic differences in the transcriptional activation of... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19933256 Nov 20. Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms. |
| GO:0005515 protein binding | IPI PMID:20075864 Coordinated regulation of p53 apoptotic targets BAX and PUMA... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20075864 Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. |
| GO:0005515 protein binding | IPI PMID:20134482 Skp2B attenuates p53 function by inhibiting prohibitin. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20134482 Skp2B attenuates p53 function by inhibiting prohibitin. |
| GO:0005515 protein binding | IPI PMID:20153329 Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 int... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20153329 2010 Feb 12. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions. |
| GO:0005515 protein binding | IPI PMID:20159018 Identification and characterization of the novel protein CCD... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20159018 Epub 2010 Feb 14. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. |
| GO:0005515 protein binding | IPI PMID:20167603 DYRK1A and DYRK3 promote cell survival through phosphorylati... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20167603 2010 Feb 18. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. |
| GO:0005515 protein binding | IPI PMID:20173098 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20173098 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:20206173 Structure of the p53 C-terminus bound to 14-3-3: implication... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20206173 2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer. |
| GO:0005515 protein binding | IPI PMID:20227041 Modulation of the vitamin D3 response by cancer-associated m... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20227041 Modulation of the vitamin D3 response by cancer-associated mutant p53. |
| GO:0005515 protein binding | IPI PMID:20228809 BRD7 is a candidate tumour suppressor gene required for p53 ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20228809 BRD7 is a candidate tumour suppressor gene required for p53 function. |
| GO:0005515 protein binding | IPI PMID:20385133 p53 inhibits tumor cell invasion via the degradation of snai... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20385133 2010 Apr 10. p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. |
| GO:0005515 protein binding | IPI PMID:20421506 Mapping the physical and functional interactions between the... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20421506 Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. |
| GO:0005515 protein binding | IPI PMID:20452352 A novel hPirh2 splicing variant without ubiquitin protein li... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20452352 2010 May 7. A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. |
| GO:0005515 protein binding | IPI PMID:20515689 MDM4 binds ligands via a mechanism in which disordered regio... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20515689 Epub 2010 May 31. MDM4 binds ligands via a mechanism in which disordered regions become structured. |
| GO:0005515 protein binding | IPI PMID:20534433 Synaptonemal complex formation and meiotic checkpoint signal... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20534433 Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1. |
| GO:0005515 protein binding | IPI PMID:20562916 Dual-specificity phosphatase 26 is a novel p53 phosphatase a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20562916 Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. |
| GO:0005515 protein binding | IPI PMID:20591429 S100 proteins interact with the N-terminal domain of MDM2. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20591429 Epub 2010 Jun 19. S100 proteins interact with the N-terminal domain of MDM2. |
| GO:0005515 protein binding | IPI PMID:20622899 PBK/TOPK interacts with the DBD domain of tumor suppressor p... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20622899 PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21. |
| GO:0005515 protein binding | IPI PMID:20660729 Polybromo-associated BRG1-associated factor components BRD7 ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20660729 Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. |
| GO:0005515 protein binding | IPI PMID:20705607 Turning the RING domain protein MdmX into an active ubiquiti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20705607 Epub 2010 Aug 12. Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. |
| GO:0005515 protein binding | IPI PMID:20708156 Phosphorylation by casein kinase I promotes the turnover of ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20708156 Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. |
| GO:0005515 protein binding | IPI PMID:20713054 ARF-dependent regulation of ATM and p53 associated KZNF (Apa... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20713054 Epub 2010 Aug 14. ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress. |
| GO:0005515 protein binding | IPI PMID:20864041 MAGE-RING protein complexes comprise a family of E3 ubiquiti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20864041 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. |
| GO:0005515 protein binding | IPI PMID:21057547 AXIN is an essential co-activator for the promyelocytic leuk... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21057547 Nov 8. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. |
| GO:0005515 protein binding | IPI PMID:21078964 p53-mediated apoptosis requires inositol hexakisphosphate ki... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21078964 p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. |
| GO:0005515 protein binding | IPI PMID:21081126 Anti-apoptotic protein TCTP controls the stability of the tu... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21081126 2010 Nov 17. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. |
| GO:0005515 protein binding | IPI PMID:21130767 SAFB1 interacts with and suppresses the transcriptional acti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21130767 2010 Dec 3. SAFB1 interacts with and suppresses the transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:21132010 GNL3L depletion destabilizes MDM2 and induces p53-dependent ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21132010 GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest. |
| GO:0005515 protein binding | IPI PMID:21170034 TSPYL5 suppresses p53 levels and function by physical intera... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21170034 TSPYL5 suppresses p53 levels and function by physical interaction with USP7. |
| GO:0005515 protein binding | IPI PMID:21170087 Ribosomal protein S27-like and S27 interplay with p53-MDM2 a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21170087 Dec 20. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. |
| GO:0005515 protein binding | IPI PMID:21245319 Methyltransferase Set7/9 regulates p53 activity by interacti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21245319 Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). |
| GO:0005515 protein binding | IPI PMID:21317932 A new role of NUAK1: directly phosphorylating p53 and regula... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21317932 A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. |
| GO:0005515 protein binding | IPI PMID:21390126 Inactivating mutations of acetyltransferase genes in B-cell ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21390126 Inactivating mutations of acetyltransferase genes in B-cell lymphoma. |
| GO:0005515 protein binding | IPI PMID:21397192 Interferon-inducible protein 16: insight into the interactio... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21397192 Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. |
| GO:0005515 protein binding | IPI PMID:21423215 Camptothecin-induced downregulation of MLL5 contributes to t... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21423215 Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53. |
| GO:0005515 protein binding | IPI PMID:21460856 ATM-mediated phosphorylation activates the tumor-suppressive... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21460856 ATM-mediated phosphorylation activates the tumor-suppressive function of B56Ξ³-PP2A. |
| GO:0005515 protein binding | IPI PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21471221 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation. |
| GO:0005515 protein binding | IPI PMID:21513714 The ASPP proteins complex and cooperate with p300 to modulat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21513714 Epub 2011 Apr 18. The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:21625211 COP9 signalosome subunit 6 stabilizes COP1, which functions ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21625211 COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3Ο. |
| GO:0005515 protein binding | IPI PMID:21653829 Protein interactome reveals converging molecular pathways am... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21653829 Protein interactome reveals converging molecular pathways among autism disorders. |
| GO:0005515 protein binding | IPI PMID:21670263 Structural and functional characterization of an atypical ac... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21670263 Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). |
| GO:0005515 protein binding | IPI PMID:21726810 Caspase-2-mediated cleavage of Mdm2 creates a p53-induced po... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21726810 Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. |
| GO:0005515 protein binding | IPI PMID:21741598 A Pin1/mutant p53 axis promotes aggressiveness in breast can... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21741598 A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. |
| GO:0005515 protein binding | IPI PMID:21782458 Structural basis of substrate methylation and inhibition of ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21782458 Jul 21. Structural basis of substrate methylation and inhibition of SMYD2. |
| GO:0005515 protein binding | IPI PMID:21821029 Aurora-A phosphorylates hnRNPK and disrupts its interaction ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21821029 2011 Aug 3. Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53. |
| GO:0005515 protein binding | IPI PMID:21831840 Wild-type p53 controls cell motility and invasion by dual re... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21831840 Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. |
| GO:0005515 protein binding | IPI PMID:21857681 A stress response pathway regulates DNA damage through Ξ²2-ad... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21857681 A stress response pathway regulates DNA damage through Ξ²2-adrenoreceptors and Ξ²-arrestin-1. |
| GO:0005515 protein binding | IPI PMID:21892170 Structural analysis of the interaction between Hsp90 and the... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21892170 Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21900206 A directed protein interaction network for investigating intracellular signal transduction. |
| GO:0005515 protein binding | IPI PMID:21952639 NIRF constitutes a nodal point in the cell cycle network and... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21952639 Oct 1. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21988832 Toward an understanding of the protein interaction network of the human liver. |
| GO:0005515 protein binding | IPI PMID:22056774 Bilateral inhibition of HAUSP deubiquitinase by a viral inte... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22056774 Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. |
| GO:0005515 protein binding | IPI PMID:22085928 Regulation of p53 stability and function by the deubiquitina... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22085928 Regulation of p53 stability and function by the deubiquitinating enzyme USP42. |
| GO:0005515 protein binding | IPI PMID:22103682 Specific domains of nucleolin interact with Hdm2 and antagon... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22103682 2011 Dec 19. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination. |
| GO:0005515 protein binding | IPI PMID:22124327 Positive regulation of p53 stability and activity by the deu... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22124327 Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. |
| GO:0005515 protein binding | IPI PMID:22265415 Mutant p53 disrupts mammary tissue architecture via the meva... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22265415 Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. |
| GO:0005515 protein binding | IPI PMID:22340593 Aurora kinase-A inactivates DNA damage-induced apoptosis and... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22340593 Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. |
| GO:0005515 protein binding | IPI PMID:22451927 Role of the translationally controlled tumor protein in DNA ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22451927 Role of the translationally controlled tumor protein in DNA damage sensing and repair. |
| GO:0005515 protein binding | IPI PMID:22499945 Atg7 modulates p53 activity to regulate cell cycle and survi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22499945 Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. |
| GO:0005515 protein binding | IPI PMID:22510990 AKT-dependent phosphorylation of Niban regulates nucleophosm... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22510990 AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. |
| GO:0005515 protein binding | IPI PMID:22575647 An autoregulatory feedback loop between Mdm2 and SHP that fi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22575647 Epub 2012 Mar 23. An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability. |
| GO:0005515 protein binding | IPI PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-s... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. |
| GO:0005515 protein binding | IPI PMID:22659184 Mutational analysis reveals a dual role of Mdm2 acidic domai... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22659184 Epub 2012 May 31. Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability. |
| GO:0005515 protein binding | IPI PMID:22723347 Differentiated embryo-chondrocyte expressed gene 1 regulates... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22723347 Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. |
| GO:0005515 protein binding | IPI PMID:22726440 p53 opens the mitochondrial permeability transition pore to ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22726440 p53 opens the mitochondrial permeability transition pore to trigger necrosis. |
| GO:0005515 protein binding | IPI PMID:22810585 Viral immune modulators perturb the human molecular network ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22810585 Viral immune modulators perturb the human molecular network by common and unique strategies. |
| GO:0005515 protein binding | IPI PMID:22810586 Interpreting cancer genomes using systematic host network pe... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22810586 Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. |
| GO:0005515 protein binding | IPI PMID:22819825 TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degrada... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22819825 Epub 2012 Jul 20. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation. |
| GO:0005515 protein binding | IPI PMID:22975381 A "twist box" code of p53 inactivation: twist box: p53 inter... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22975381 A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. |
| GO:0005515 protein binding | IPI PMID:23010591 Structural features of human histone acetyltransferase p300 ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23010591 2012 Sep 23. Structural features of human histone acetyltransferase p300 and its complex with p53. |
| GO:0005515 protein binding | IPI PMID:23063560 HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 tra... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23063560 2012 Oct 11. HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail. |
| GO:0005515 protein binding | IPI PMID:23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cyc... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:23320542 Evidence for self-association of the alternative sigma facto... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23320542 Evidence for self-association of the alternative sigma factor Ο54. |
| GO:0005515 protein binding | IPI PMID:23576507 Rotavirus-encoded nonstructural protein 1 modulates cellular... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23576507 Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53. |
| GO:0005515 protein binding | IPI PMID:23623661 Restoring p53 function in human melanoma cells by inhibiting... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23623661 2013 Apr 25. Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. |
| GO:0005515 protein binding | IPI PMID:23734815 Fludarabine treatment favors the retention of miR-485-3p by ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23734815 Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival. |
| GO:0005515 protein binding | IPI PMID:23752197 S100A4 interacts with p53 in the nucleus and promotes p53 de... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23752197 S100A4 interacts with p53 in the nucleus and promotes p53 degradation. |
| GO:0005515 protein binding | IPI PMID:23776060 Identification of a second Nutlin-3 responsive interaction s... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23776060 Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. |
| GO:0005515 protein binding | IPI PMID:23870121 SET1 and p300 act synergistically, through coupled histone m... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23870121 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. |
| GO:0005515 protein binding | IPI PMID:24207125 Transient protein states in designing inhibitors of the MDM2... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24207125 2013 Oct 24. Transient protein states in designing inhibitors of the MDM2-p53 interaction. |
| GO:0005515 protein binding | IPI PMID:24219989 Acetylation of p53 stimulates miRNA processing and determine... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24219989 Nov 12. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. |
| GO:0005515 protein binding | IPI PMID:24380853 The aberrant expression and localization of prohibitin durin... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24380853 2013 Dec 28. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells. |
| GO:0005515 protein binding | IPI PMID:24449765 Activation of p53 transcriptional activity by SMRT: a histon... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24449765 Jan 21. Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor. |
| GO:0005515 protein binding | IPI PMID:24492002 VRK1 interacts with p53 forming a basal complex that is acti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24492002 2014 Jan 31. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. |
| GO:0005515 protein binding | IPI PMID:24667498 JMJD6 promotes colon carcinogenesis through negative regulat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24667498 eCollection 2014 Mar. |
| GO:0005515 protein binding | IPI PMID:24722188 Protein interaction network of alternatively spliced isoform... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. |
| GO:0005515 protein binding | IPI PMID:24814347 The DNA-binding domain mediates both nuclear and cytosolic f... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24814347 May 11. The DNA-binding domain mediates both nuclear and cytosolic functions of p53. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25241761 Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. |
| GO:0005515 protein binding | IPI PMID:25314079 Acetylation of snail modulates the cytokinome of cancer cell... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25314079 Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. |
| GO:0005515 protein binding | IPI PMID:25402006 In silico prediction of physical protein interactions and ch... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. |
| GO:0005515 protein binding | IPI PMID:25502805 A massively parallel pipeline to clone DNA variants and exam... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25502805 eCollection 2014 Dec. |
| GO:0005515 protein binding | IPI PMID:25579814 Structural plasticity of methyllysine recognition by the tan... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25579814 Jan 8. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. |
| GO:0005515 protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. |
| GO:0005515 protein binding | IPI PMID:25651062 An acetyl-methyl switch drives a conformational change in p5... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25651062 An acetyl-methyl switch drives a conformational change in p53. |
| GO:0005515 protein binding | IPI PMID:25670079 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to meta... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25670079 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. |
| GO:0005515 protein binding | IPI PMID:25837623 Regulation of protein quality control by UBE4B and LSD1 thro... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25837623 eCollection 2015 Apr. |
| GO:0005515 protein binding | IPI PMID:25857266 Pontin, a new mutant p53-binding protein, promotes gain-of-f... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25857266 2015 Apr 10. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. |
| GO:0005515 protein binding | IPI PMID:26302407 Combined CSL and p53 downregulation promotes cancer-associat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:26302407 Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. |
| GO:0005515 protein binding | IPI PMID:26331536 Gain-of-function p53 mutants co-opt chromatin pathways to dr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:26331536 Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. |
| GO:0005515 protein binding | IPI PMID:26789255 Structure of the E6/E6AP/p53 complex required for HPV-mediat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:26789255 Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. |
| GO:0005515 protein binding | IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. |
| GO:0005515 protein binding | IPI PMID:27519799 p53 down-regulates SARS coronavirus replication and is targe... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:27519799 p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. |
| GO:0005515 protein binding | IPI PMID:27605672 Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Intera... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:27605672 Nov 15. Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway. |
| GO:0005515 protein binding | IPI PMID:29187402 The E3 Ligase RING1 Targets p53 for Degradation and Promotes... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:29187402 Epub 2017 Nov 29. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival. |
| GO:0005515 protein binding | IPI PMID:29340707 VRK1 and AURKB form a complex that cross inhibit their kinas... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:29340707 Epub 2018 Jan 16. VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis. |
| GO:0005515 protein binding | IPI PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid tec... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. |
| GO:0005515 protein binding | IPI PMID:31467278 Maximizing binary interactome mapping with a minimal number ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:31467278 Maximizing binary interactome mapping with a minimal number of assays. |
| GO:0005515 protein binding | IPI PMID:31511497 miR-146a attenuates apoptosis and modulates autophagy by tar... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:31511497 miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:31515488 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. |
| GO:0005515 protein binding | IPI PMID:31837246 High-throughput competitive fluorescence polarization assay ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. |
| GO:0005515 protein binding | IPI PMID:32606738 P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:32606738 eCollection 2020. P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:34316702 Elucidation of the BMI1 interactome identifies novel regulat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:34316702 2021 Mar. Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma. |
| GO:0005515 protein binding | IPI PMID:34591612 A protein interaction landscape of breast cancer. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:34591612 Oct 1. A protein interaction landscape of breast cancer. |
| GO:0005515 protein binding | IPI PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:34591642 Oct 1. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. |
| GO:0005515 protein binding | IPI PMID:35044719 Proteome-scale mapping of binding sites in the unstructured ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:35044719 Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. |
| GO:0005515 protein binding | IPI PMID:35140242 Human transcription factor protein interaction networks. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:35140242 Human transcription factor protein interaction networks. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:35271311 2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human cells. |
| GO:0005515 protein binding | IPI PMID:39009827 Proteome-scale characterisation of motif-based interactome r... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:39009827 2024 Jul 15. Proteome-scale characterisation of motif-based interactome rewiring by disease mutations. |
| GO:0005515 protein binding | IPI PMID:7799929 Two domains of p53 interact with the TATA-binding protein, a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:7799929 Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. |
| GO:0005515 protein binding | IPI PMID:8207801 Inhibition of p53 DNA binding by human papillomavirus E6 pro... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:8207801 Inhibition of p53 DNA binding by human papillomavirus E6 proteins. |
| GO:0005515 protein binding | IPI PMID:8344494 Identification of mutations in p53 that affect its binding t... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:8344494 Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. |
| GO:0005515 protein binding | IPI PMID:8875926 Structure of the p53 tumor suppressor bound to the ankyrin a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:8875926 Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. |
| GO:0005515 protein binding | IPI PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| GO:0005515 protein binding | IPI PMID:9050995 Identification of p53 unbound to T-antigen in human cells tr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9050995 Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen. |
| GO:0005515 protein binding | IPI PMID:9188558 Nuclear localization of the NS3 protein of hepatitis C virus... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9188558 Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization. |
| GO:0005515 protein binding | IPI PMID:9194564 Synergistic activation of transcription by CBP and p53. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9194564 Synergistic activation of transcription by CBP and p53. |
| GO:0005515 protein binding | IPI PMID:9380510 Interaction of p53 with the human Rad51 protein. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9380510 Interaction of p53 with the human Rad51 protein. |
| GO:0005515 protein binding | IPI PMID:9472015 High mobility group protein-1 (HMG-1) is a unique activator ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9472015 High mobility group protein-1 (HMG-1) is a unique activator of p53. |
| GO:0005515 protein binding | IPI PMID:9807817 An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKB... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9807817 An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. |
| GO:0005515 protein binding | IPI PMID:9827557 Complex formation of the nonstructural protein 3 of hepatiti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9827557 Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor. |
| GO:0042802 identical protein binding | IPI PMID:10876243 Structure of the negative regulatory domain of p53 bound to ... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:16291740 Charge modification at multiple C-terminal lysine residues r... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:16461914 Core domain interactions in full-length p53 in solution. | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to de... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implicat... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:20004160 Averaging of electron subtomograms and random conical tilt r... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:20159469 Crystal structure of the p53 core domain bound to a full con... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:20364130 Diversity in DNA recognition by p53 revealed by crystal stru... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:21178074 Electron microscopy studies on the quaternary structure of p... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics ... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-s... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:22972749 Domain-domain interactions in full-length p53 and a specific... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:25402006 In silico prediction of physical protein interactions and ch... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:31837246 High-throughput competitive fluorescence polarization assay ... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0042802 identical protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0017053 transcription repressor complex | IPI PMID:18677113 Structure of the human Mdmx protein bound to the p53 tumor s... | ACCEPT | Summary: p53 functions within transcriptional regulator complexes to control gene expression. Reason: Core function - p53 forms complexes with transcriptional machinery and co-factors. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:18677113 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| GO:0017053 transcription repressor complex | IPI PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... | ACCEPT | Summary: p53 functions within transcriptional regulator complexes to control gene expression. Reason: Core function - p53 forms complexes with transcriptional machinery and co-factors. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:18677113 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| GO:0045892 negative regulation of DNA-templated transcription | NAS PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in prolifera... | ACCEPT | Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes. Reason: Core function - p53 acts as both a transcriptional activator and repressor. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mechanism. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
| GO:0045892 negative regulation of DNA-templated transcription | IDA PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mec... | ACCEPT | Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes. Reason: Core function - p53 acts as both a transcriptional activator and repressor. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mechanism. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
| GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA GO_REF:0000107 | ACCEPT | Summary: p53 binds to RNA polymerase II cis-regulatory regions in target gene promoters. Reason: Core molecular function - sequence-specific DNA binding is essential for p53 transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IEA GO_REF:0000107 | ACCEPT | Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes. Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IEA GO_REF:0000107 | ACCEPT | Summary: p53 activates transcription through binding to promoter sequences. Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:12609999 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| GO:0003682 chromatin binding | IEA GO_REF:0000107 | ACCEPT | Summary: p53 binds chromatin at p53 response elements in target gene promoters. Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation. Supporting Evidence: PDB:3TS8 Crystal structure of p53 tetramer bound to DNA PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. |
| GO:0005657 replication fork | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is a component of replication fork DNA repair machinery. Reason: p53 coordinates DNA repair at replication forks during DNA damage response. |
| GO:0005739 mitochondrion | IEA GO_REF:0000107 | ACCEPT | Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation. Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins PMID:25168243 Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0007623 circadian rhythm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 may influence circadian rhythms but this is not a primary function. Reason: Non-core function - p53 has connections to circadian biology. |
| GO:0008285 negative regulation of cell population proliferation | IEA GO_REF:0000107 | ACCEPT | Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism. Reason: Core function - p53 inhibits proliferation through cell cycle arrest. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. |
| GO:0008340 determination of adult lifespan | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 may influence lifespan through its regulation of senescence and apoptosis. Reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function. |
| GO:0031625 ubiquitin protein ligase binding | IEA GO_REF:0000120 | REMOVE | Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions. Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere. |
| GO:0034644 cellular response to UV | IEA GO_REF:0000107 | ACCEPT | Summary: p53 responds to UV-induced DNA damage as part of its DNA damage response. Reason: Core function - UV radiation is a classic p53-activating stress. Supporting Evidence: GO:0009411 response to UV PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0035033 histone deacetylase regulator activity | IEA GO_REF:0000107 | ACCEPT | Summary: p53 undergoes deacetylation by histone deacetylases including HDAC1. Reason: Core regulatory mechanism - p53 deacetylation by HDACs regulates its activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Acetylation/deacetylation regulates p53 function |
| GO:0035861 site of double-strand break | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 is involved in ventral column development in spinal cord. Reason: Non-core tissue-specific developmental function. |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0043073 germ cell nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 is involved in germ cell development but is not essential. Reason: Non-core developmental function. |
| GO:0043153 entrainment of circadian clock by photoperiod | IEA GO_REF:0000107 | ACCEPT | Summary: p53 enters the nucleus to function as a transcription factor. Reason: Core process - nuclear entry is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Nuclear Localization Signals (NLS): Function: Nuclear import and localization |
| GO:0045892 negative regulation of DNA-templated transcription | IEA GO_REF:0000107 | ACCEPT | Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes. Reason: Core function - p53 acts as both a transcriptional activator and repressor. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mechanism. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
| GO:0048512 circadian behavior | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 is involved in organ development but is not essential for development. Reason: Non-core developmental function - p53 knockout mice develop normally. |
| GO:0060333 type II interferon-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: p53 may influence interferon-gamma signaling but this is not a primary function. Reason: Non-core immunomodulatory function. |
| GO:0062100 positive regulation of programmed necrotic cell death | IEA GO_REF:0000107 | ACCEPT | Summary: p53 regulates intrinsic apoptotic signaling in response to various DNA damage types. Reason: Core function - p53 responds to diverse DNA damage to trigger apoptosis. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA GO_REF:0000107 | ACCEPT | Summary: p53 is phosphorylated on serine residues including Ser15, Ser20, Ser46, Ser392. Reason: Core regulatory mechanism - serine phosphorylation is essential for p53 activation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Ser15, Thr18, Ser20: N-terminal phosphorylation by ATM/ATR, disrupts MDM2 binding |
| GO:0070245 positive regulation of thymocyte apoptotic process | IEA GO_REF:0000107 | ACCEPT | Summary: p53 responds to positive regulation by stress-induced post-translational modifications. Reason: p53 is regulated by extensive post-translational modifications that enhance its activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 can be modified at over 60 of its 393 residues |
| GO:0071479 cellular response to ionizing radiation | IEA GO_REF:0000107 | ACCEPT | Summary: p53 responds to UV-A radiation-induced DNA damage. Reason: Core DNA damage response function - UV radiation is a classic p53 activator. Supporting Evidence: GO:0009411 response to UV PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. |
| GO:0097371 MDM2/MDM4 family protein binding | IEA GO_REF:0000107 | ACCEPT | Summary: p53 undergoes mitochondrial translocation to directly promote apoptosis. Reason: Important function - p53 can induce apoptosis through non-transcriptional mitochondrial mechanisms. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Direct mitochondrial translocation and interaction with BCL-2 family proteins |
| GO:2000774 positive regulation of cellular senescence | IEA GO_REF:0000107 | ACCEPT | Summary: p53 positively regulates cellular senescence as an alternative to apoptosis. Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism PMID:29474172 Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. |
| GO:0005654 nucleoplasm | IDA PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0072331 signal transduction by p53 class mediator | IDA PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that ... | ACCEPT | Summary: p53 IS the p53 class mediator that transduces signals in response to stress. Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:1990841 promoter-specific chromatin binding | IDA PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... | ACCEPT | Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements. Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding. Supporting Evidence: PDB:3TS8 Crystal structure shows p53 binding to CDKN1A(p21) promoter response element PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20725088 2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. |
| GO:0072331 signal transduction by p53 class mediator | IDA PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... | ACCEPT | Summary: p53 IS the p53 class mediator that transduces signals in response to stress. Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:0000785 chromatin | IDA PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0003700 DNA-binding transcription factor activity | IMP PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... | ACCEPT | Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes. Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IDA PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0010628 positive regulation of gene expression | ISS GO_REF:0000024 | ACCEPT | Summary: p53 positively regulates gene expression of numerous target genes. Reason: Core transcriptional function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism. PMID:20332243 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. |
| GO:0001223 transcription coactivator binding | IPI PMID:11950834 SWI/SNF complex interacts with tumor suppressor p53 and is n... | ACCEPT | Summary: p53 functions as a transcription activator at p53 response elements. Reason: Core molecular function - p53 activates transcription at cis-regulatory elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 binds sequence-specifically to p53 response elements PMID:11950834 2002 Apr 11. SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IDA PMID:15149599 Telomere shortening triggers senescence of human cells throu... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:34381247 The tumor suppressor folliculin inhibits lactate dehydrogena... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0005634 nucleus | IDA PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005634 nucleus | IDA PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:38653238 Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lacty... | ACCEPT | Summary: p53 binds to single-stranded DNA through its DNA-binding domain. Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions. Supporting Evidence: PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and tr... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:36634798 Phosphorylation and specific DNA improved the incorporation ... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:38653238 Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lacty... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0005634 nucleus | IDA PMID:36108750 Phase separation of p53 induced by its unstructured basic re... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:31953488 Liquid-like droplet formation by tumor suppressor p53 induce... | ACCEPT | Summary: p53 binds to single-stranded DNA through its DNA-binding domain. Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions. Supporting Evidence: PMID:31953488 Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and tr... | ACCEPT | Summary: p53 binds to single-stranded DNA through its DNA-binding domain. Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions. Supporting Evidence: PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:36108750 Phase separation of p53 induced by its unstructured basic re... | ACCEPT | Summary: p53 binds to single-stranded DNA through its DNA-binding domain. Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions. Supporting Evidence: PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. |
| GO:0140693 molecular condensate scaffold activity | IDA PMID:36634798 Phosphorylation and specific DNA improved the incorporation ... | ACCEPT | Summary: p53 binds to single-stranded DNA through its DNA-binding domain. Reason: p53 can bind single-stranded DNA as part of its DNA repair and damage sensing functions. Supporting Evidence: PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IMP PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0032211 negative regulation of telomere maintenance via telomerase | IDA PMID:10597287 Molecular interactions between telomerase and the tumor supp... | ACCEPT | Summary: p53 negatively regulates telomerase activity. Reason: p53 suppresses telomerase as part of its tumor suppressor function. Supporting Evidence: PMID:10597287 Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0005515 protein binding | IPI PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. |
| GO:0005634 nucleus | IDA PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005634 nucleus | IDA PMID:26634371 Structural studies of UBXN2A and mortalin interaction and th... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, prom... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:26634371 Structural studies of UBXN2A and mortalin interaction and th... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0003682 chromatin binding | IDA PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... | ACCEPT | Summary: p53 binds chromatin at p53 response elements in target gene promoters. Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation. Supporting Evidence: PDB:3TS8 Crystal structure of p53 tetramer bound to DNA PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... | ACCEPT | Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes. Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0005515 protein binding | IPI PMID:26334721 Jmjd5 functions as a regulator of p53 signaling during mouse... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... | ACCEPT | Summary: p53 regulates RNA polymerase II transcription as both activator and repressor. Reason: Core molecular function - p53 is a sequence-specific RNA pol II transcription factor. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. |
| GO:0006974 DNA damage response | IDA PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes. Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0072331 signal transduction by p53 class mediator | IDA PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53... | ACCEPT | Summary: p53 IS the p53 class mediator that transduces signals in response to stress. Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9836362 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005515 protein binding | IPI PMID:35122041 Aldolase B suppresses hepatocellular carcinogenesis by inhib... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:35122041 Jul 6. Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. |
| GO:0005515 protein binding | IPI PMID:10415337 Identification of a novel gene encoding a p53-associated pro... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10415337 Identification of a novel gene encoding a p53-associated protein. |
| GO:0005515 protein binding | IPI PMID:10666337 Human topoisomerase IIalpha and IIbeta interact with the C-t... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10666337 Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53. |
| GO:0005515 protein binding | IPI PMID:11546806 Cloning and characterization of a p53-related protein kinase... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11546806 2001 Sep 6. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. |
| GO:0005515 protein binding | IPI PMID:11781842 The Bloom syndrome protein interacts and cooperates with p53... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11781842 The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. |
| GO:0005515 protein binding | IPI PMID:15577914 Regulation of cellular response to oncogenic and oxidative s... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15577914 Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. |
| GO:0005515 protein binding | IPI PMID:17121812 CARPs are ubiquitin ligases that promote MDM2-independent p5... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17121812 Nov 22. CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. |
| GO:0005515 protein binding | IPI PMID:18382127 CARPs enhance p53 turnover by degrading 14-3-3sigma and stab... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18382127 CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. |
| GO:0005515 protein binding | IPI PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repair activity. |
| GO:0005515 protein binding | IPI PMID:9194565 Binding and modulation of p53 by p300/CBP coactivators. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9194565 Binding and modulation of p53 by p300/CBP coactivators. |
| GO:0005515 protein binding | IPI PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. |
| GO:0010628 positive regulation of gene expression | IDA PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates... | ACCEPT | Summary: p53 positively regulates gene expression of numerous target genes. Reason: Core transcriptional function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism. PMID:20332243 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. |
| GO:0005515 protein binding | IPI PMID:34404770 ZNF768 links oncogenic RAS to cellular senescence. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:34404770 ZNF768 links oncogenic RAS to cellular senescence. |
| GO:0045815 transcription initiation-coupled chromatin remodeling | IDA PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | ACCEPT | Summary: p53 positively regulates gene expression through transcriptional activation. Reason: Core function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:33591310 DAZAP2 acts as specifier of the p53 response to DNA damage. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:33591310 DAZAP2 acts as specifier of the p53 response to DNA damage. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... | ACCEPT | Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes. Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:2000774 positive regulation of cellular senescence | IDA PMID:29474172 Haploinsufficiency of Trp53 dramatically extends the lifespa... | ACCEPT | Summary: p53 positively regulates cellular senescence as an alternative to apoptosis. Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism PMID:29474172 Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. |
| GO:0031625 ubiquitin protein ligase binding | EXP PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... | REMOVE | Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions. Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere. Supporting Evidence: PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| GO:0071889 14-3-3 protein binding | EXP PMID:20206173 Structure of the p53 C-terminus bound to 14-3-3: implication... | ACCEPT | Summary: p53 binds to 14-3-3 proteins which regulate its subcellular localization. Reason: Important regulatory interaction - 14-3-3 proteins sequester p53 in cytoplasm. Supporting Evidence: PMID:20206173 2010 Mar 3. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer. |
| GO:0140677 molecular function activator activity | EXP PMID:14759370 Structural mechanism of the bromodomain of the coactivator C... | ACCEPT | Summary: p53 functions as an activating transcription factor for target genes. Reason: Core molecular function - p53 activates transcription of target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. PMID:7559631 Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein. |
| GO:0140677 molecular function activator activity | EXP PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interac... | ACCEPT | Summary: p53 functions as an activating transcription factor for target genes. Reason: Core molecular function - p53 activates transcription of target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. PMID:7559631 Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein. |
| GO:0140677 molecular function activator activity | IPI PMID:7559631 Transactivation ability of p53 transcriptional activation do... | ACCEPT | Summary: p53 functions as an activating transcription factor for target genes. Reason: Core molecular function - p53 activates transcription of target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:16793543 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. PMID:7559631 Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein. |
| GO:2000774 positive regulation of cellular senescence | ISS GO_REF:0000024 | ACCEPT | Summary: p53 positively regulates cellular senescence as an alternative to apoptosis. Reason: Core function - senescence induction is a major tumor suppressor mechanism of p53. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 induces senescence through p21 and other targets as an irreversible cell cycle arrest mechanism PMID:29474172 Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice. |
| GO:0090398 cellular senescence | IMP PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... | ACCEPT | Summary: p53 is negatively regulated by MDM2-mediated cellular homeostasis. Reason: Core regulatory mechanism - p53 is tightly regulated in non-stressed cells. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Negative Feedback: MDM2: Primary negative regulator PMID:12080348 Nucleophosmin regulates the stability and transcriptional activity of p53. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-2997706 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005515 protein binding | IPI PMID:15687255 A mechanism of ubiquitin-independent proteasomal degradation... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15687255 A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IDA PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... | ACCEPT | Summary: p53 activates transcription through binding to promoter sequences. Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:12609999 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... | ACCEPT | Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes. Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. |
| GO:1902895 positive regulation of miRNA transcription | IMP PMID:22578566 Oncosuppressive role of p53-induced miR-205 in triple negati... | ACCEPT | Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family. Reason: p53 regulates miRNA expression as part of its stress response functions. Supporting Evidence: PMID:30089260 we found p53-dependent induction of these miRNAs upon nutlin-3a treatment PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:20546595 High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IDA PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... | ACCEPT | Summary: p53 activates transcription through binding to promoter sequences. Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:12609999 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:23329847 Regulation of the cyclin-dependent kinase inhibitor 1A gene ... | ACCEPT | Summary: p53 binds RNA through its C-terminal domain. Reason: p53 has RNA-binding activity that contributes to regulation of gene expression. Supporting Evidence: PMID:23329847 2013 Jan 17. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:15705871 Homeobox Msx1 interacts with p53 tumor suppressor and inhibi... | ACCEPT | Summary: p53 binds RNA through its C-terminal domain. Reason: p53 has RNA-binding activity that contributes to regulation of gene expression. Supporting Evidence: PMID:15705871 Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis. |
| GO:0051726 regulation of cell cycle | IGI PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic e... | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0051726 regulation of cell cycle | IGI PMID:12433990 Distinct promoter elements mediate the co-operative effect o... | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0051726 regulation of cell cycle | IDA PMID:15149599 Telomere shortening triggers senescence of human cells throu... | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0051726 regulation of cell cycle | IMP PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... | ACCEPT | Summary: p53 is a master regulator of the cell cycle, inducing arrest at G1/S and G2/M checkpoints. Reason: Core function - cell cycle regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt induces cell cycle arrest PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IDA PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... | ACCEPT | Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes. Reason: Core function - transcriptional repression is part of p53's regulatory activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. PMID:19749791 Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. |
| GO:0000987 cis-regulatory region sequence-specific DNA binding | IDA PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... | ACCEPT | Summary: p53 binds to proximal promoter sequences containing p53 response elements. Reason: Core molecular function - DNA binding to promoters is essential for p53 activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 binds sequence-specifically to p53 response elements in target gene promoters PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. |
| GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the B... | ACCEPT | Summary: p53 functions as a transcriptional repressor at specific promoters. Reason: Core function - p53 represses transcription of target genes. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2) PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. |
| GO:1903451 negative regulation of G1 to G0 transition | IDA PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... | ACCEPT | Summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance. Reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Anti-ferroptotic: Induces p21 to maintain GSH levels PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:21471221 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation. |
| GO:1903451 negative regulation of G1 to G0 transition | IMP PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... | ACCEPT | Summary: p53 negatively regulates ferroptosis through p21 induction and GSH maintenance. Reason: p53 has dual role in ferroptosis - this represents its anti-ferroptotic activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Anti-ferroptotic: Induces p21 to maintain GSH levels PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:21471221 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation. |
| GO:0005515 protein binding | IPI PMID:25168243 Cofactor Strap regulates oxidative phosphorylation and mitoc... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25168243 Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. |
| GO:0005739 mitochondrion | IDA PMID:25168243 Cofactor Strap regulates oxidative phosphorylation and mitoc... | ACCEPT | Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation. Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins PMID:25168243 Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:19505873 Complementary quantitative proteomics reveals that transcrip... | ACCEPT | Summary: p53 binds RNA through its C-terminal domain. Reason: p53 has RNA-binding activity that contributes to regulation of gene expression. Supporting Evidence: PMID:19505873 Epub 2009 Jun 7. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. |
| GO:0036310 ATP-dependent DNA/DNA annealing activity | IDA PMID:8183576 Human p53 directs DNA strand reassociation and is photolabel... | ACCEPT | Summary: p53 responds to chemotherapy drugs that cause DNA damage. Reason: Core function - DNA-damaging chemotherapeutics strongly activate p53. Supporting Evidence: PMID:8183576 Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9723906 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0140296 general transcription initiation factor binding | IPI PMID:15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p5... | ACCEPT | Summary: p53 binds chromatin to regulate transcription of target genes. Reason: Core function - chromatin binding is essential for p53's transcription factor activity. Supporting Evidence: PDB:3TS8 Crystal structure shows p53 bound to DNA PMID:15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. |
| GO:0010628 positive regulation of gene expression | IDA PMID:20332243 MicroRNA145 targets BNIP3 and suppresses prostate cancer pro... | ACCEPT | Summary: p53 positively regulates gene expression of numerous target genes. Reason: Core transcriptional function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism. PMID:20332243 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. |
| GO:1902895 positive regulation of miRNA transcription | IDA PMID:20546595 High-throughput sequencing identifies STAT3 as the DNA-assoc... | ACCEPT | Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family. Reason: p53 regulates miRNA expression as part of its stress response functions. Supporting Evidence: PMID:30089260 we found p53-dependent induction of these miRNAs upon nutlin-3a treatment PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:20546595 High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. |
| GO:0000785 chromatin | IMP PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a... | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:1902895 positive regulation of miRNA transcription | IGI PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneo... | ACCEPT | Summary: p53 transcriptionally regulates multiple miRNAs including miR-34 family. Reason: p53 regulates miRNA expression as part of its stress response functions. Supporting Evidence: PMID:30089260 we found p53-dependent induction of these miRNAs upon nutlin-3a treatment PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:20546595 High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IDA PMID:12609999 The activation domains, the proline-rich domain, and the C-t... | ACCEPT | Summary: p53 activates transcription through binding to promoter sequences. Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:12609999 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| GO:0043066 negative regulation of apoptotic process | IGI PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic e... | ACCEPT | Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival. Reason: Context-dependent function - p53 can promote survival under mild stress conditions. Supporting Evidence: PMID:12203124 The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). |
| GO:0043066 negative regulation of apoptotic process | IGI PMID:12433990 Distinct promoter elements mediate the co-operative effect o... | ACCEPT | Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival. Reason: Context-dependent function - p53 can promote survival under mild stress conditions. Supporting Evidence: PMID:12433990 Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. |
| GO:0005515 protein binding | IPI PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. |
| GO:0005634 nucleus | IDA PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:21597459 E3 ubiquitin ligase Hades negatively regulates the exonuclea... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005515 protein binding | IPI PMID:29628311 A Family of Vertebrate-Specific Polycombs Encoded by the LCO... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:29628311 2018 Apr 5. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. |
| GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly | IDA PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 positively regulates its own transcription as part of feedback regulation. Reason: p53 has positive feedback regulation of its own expression. Supporting Evidence: PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:17146433 RGC32, a novel p53-inducible gene, is located on centrosomes... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IGI PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneo... | ACCEPT | Summary: p53 responds to tumor necrosis factor signaling. Reason: p53 interacts with TNF signaling pathways in cell death regulation. Supporting Evidence: PMID:22499991 Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. |
| GO:0001046 core promoter sequence-specific DNA binding | IDA PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 activates transcription through core promoter binding. Reason: Core molecular function - p53 binds promoters to activate transcription. Supporting Evidence: PDB:3TS8 p53 tetramer bound to CDKN1A promoter response element PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. |
| GO:0042802 identical protein binding | IPI PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0005515 protein binding | IPI PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mit... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression. |
| GO:0005813 centrosome | IDA PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mit... | KEEP AS NON CORE | Summary: p53 has been reported to localize to centrosomes but this is not a primary localization. Reason: Non-core localization. p53 may associate with centrosomes in certain contexts but this is not a primary function. Supporting Evidence: PMID:28842590 DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression. |
| GO:0042802 identical protein binding | IPI PMID:19011621 Arginine methylation regulates the p53 response. | ACCEPT | Summary: p53 binds to itself to form tetramers through its oligomerization domain, essential for DNA binding. Reason: Core structural feature - p53 tetramerization through identical protein binding is essential for function. Supporting Evidence: PDB:1C26 Crystal structure of p53 tetramerization domain PMID:10876243 Structure of the negative regulatory domain of p53 bound to S100B(betabeta). PMID:14759370 Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. PMID:16291740 2005 Nov 15. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. PMID:16461914 Core domain interactions in full-length p53 in solution. PMID:17612295 Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. PMID:17620598 Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. PMID:18087040 Regulation of p53 tetramerization and nuclear export by ARC. PMID:19339993 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. PMID:19667193 Ultraslow oligomerization equilibria of p53 and its implications. PMID:20004160 Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. PMID:20159469 Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. PMID:20364130 Apr 4. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. PMID:21178074 Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. PMID:21522129 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. PMID:21988832 Toward an understanding of the protein interaction network of the human liver. PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. PMID:22972749 Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy. PMID:25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. PMID:31837246 High-throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family. PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. | ACCEPT | Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism. Reason: Core function - p53 induces apoptosis through multiple pathways. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0005515 protein binding | IPI PMID:9733515 Activation of the ATM kinase by ionizing radiation and phosp... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:9733515 Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. |
| GO:0005515 protein binding | IPI PMID:16443602 WT p53, but not tumor-derived mutants, bind to Bcl2 via the ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:16443602 2006 Jan 26. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. |
| GO:0000785 chromatin | ISA GO_REF:0000113 | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | ISA GO_REF:0000113 | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0002244 hematopoietic progenitor cell differentiation | IMP PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... | KEEP AS NON CORE | Summary: p53 is involved in hematopoietic progenitor cell differentiation but is not essential. Reason: Non-core developmental function. Supporting Evidence: PMID:30146126 Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. |
| GO:0060218 hematopoietic stem cell differentiation | IMP PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... | KEEP AS NON CORE | Summary: p53 is involved in hematopoietic stem cell differentiation but is not essential. Reason: Non-core developmental function. Supporting Evidence: PMID:30146126 Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. |
| GO:0048539 bone marrow development | IMP PMID:30146126 De Novo Mutations Activating Germline TP53 in an Inherited B... | KEEP AS NON CORE | Summary: p53 influences olfactory bulb development but is not essential. Reason: Non-core developmental function - tissue-specific. Supporting Evidence: PMID:30146126 Epub 2018 Aug 23. De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. |
| GO:0005515 protein binding | IPI PMID:19011621 Arginine methylation regulates the p53 response. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19011621 Arginine methylation regulates the p53 response. |
| GO:0005634 nucleus | IDA PMID:19011621 Arginine methylation regulates the p53 response. | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:19011621 Arginine methylation regulates the p53 response. | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:2001244 positive regulation of intrinsic apoptotic signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts. Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival. |
| GO:0005515 protein binding | IPI PMID:18690848 NUPR1 interacts with p53, transcriptionally regulates p21 an... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:18690848 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. |
| GO:2001244 positive regulation of intrinsic apoptotic signaling pathway | IMP PMID:27031958 Nupr1/Chop signal axis is involved in mitochondrion-related ... | ACCEPT | Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts. Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival. Supporting Evidence: PMID:27031958 Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. |
| GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific | IDA PMID:17146433 RGC32, a novel p53-inducible gene, is located on centrosomes... | ACCEPT | Summary: p53 activates transcription through binding to promoter sequences. Reason: Core molecular function - p53 is a transcriptional activator that binds to p53 response elements. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:12609999 2003 Feb 27. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |
| GO:1990841 promoter-specific chromatin binding | IDA PMID:20725088 Primate-specific RFPL1 gene controls cell-cycle progression ... | ACCEPT | Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements. Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding. Supporting Evidence: PDB:3TS8 Crystal structure shows p53 binding to CDKN1A(p21) promoter response element PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20725088 2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. |
| GO:0005667 transcription regulator complex | IGI PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... | ACCEPT | Summary: p53 is a component of transcription factor complexes. Reason: Core localization - p53 functions as part of transcriptional machinery complexes. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | ISS GO_REF:0000024 | ACCEPT | Summary: p53 binds sequence-specifically to p53 response elements in cis-regulatory regions of target genes. Reason: Core molecular function - p53's DNA-binding domain binds to consensus p53 response elements (p53REs) with high specificity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md TP53 is fundamentally a transcription factor that binds sequence-specifically to p53 response elements (p53REs) in target gene promoters PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:22578566 Apr 19. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. |
| GO:1905856 negative regulation of pentose-phosphate shunt | IMP PMID:21336310 p53 regulates biosynthesis through direct inactivation of gl... | ACCEPT | Summary: p53 positively regulates p53-mediated DNA damage responses. Reason: Core function - p53 regulates its own signaling pathway with positive feedback. Supporting Evidence: PMID:21336310 p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. |
| GO:0006974 DNA damage response | IMP PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:1990841 promoter-specific chromatin binding | IDA PMID:24356969 Rbm24, an RNA-binding protein and a target of p53, regulates... | ACCEPT | Summary: p53 binds to promoter-specific chromatin regions containing p53 response elements. Reason: Core molecular function - p53 specifically binds to promoter regions of target genes through sequence-specific DNA binding. Supporting Evidence: PDB:3TS8 Crystal structure shows p53 binding to CDKN1A(p21) promoter response element PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20725088 2010 Aug 20. Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. |
| GO:0001094 TFIID-class transcription factor complex binding | IPI PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 interacts with TFIID to regulate transcription initiation. Reason: Core transcriptional mechanism - p53 recruits TFIID to target promoters. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with TFIID PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. |
| GO:0005634 nucleus | IMP PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IMP PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0009299 mRNA transcription | IMP PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... | KEEP AS NON CORE | Summary: p53 influences mRNA processing but this is not a core function. Reason: Non-core regulatory function. Supporting Evidence: PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IMP PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negat... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apop... | ACCEPT | Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism. Reason: Core function - p53 induces apoptosis through multiple pathways. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0005515 protein binding | IPI PMID:17904127 SVH-B interacts directly with p53 and suppresses the transcr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17904127 Epub 2007 Sep 21. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. |
| GO:0005515 protein binding | IPI PMID:25422469 Disruption of FAT10-MAD2 binding inhibits tumor progression. | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25422469 Disruption of FAT10-MAD2 binding inhibits tumor progression. |
| GO:0005515 protein binding | IPI PMID:27323408 LACE1 interacts with p53 and mediates its mitochondrial tran... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:27323408 LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. |
| GO:0005515 protein binding | IPI PMID:22522597 Nucleolar protein GLTSCR2 stabilizes p53 in response to ribo... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22522597 2012 Apr 20. Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses. |
| GO:0003677 DNA binding | IDA PMID:15358771 Hsp90 regulates the activity of wild type p53 under physiolo... | ACCEPT | Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements. Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops PMID:15358771 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:2144364 Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. |
| GO:0051087 protein-folding chaperone binding | IPI PMID:15358771 Hsp90 regulates the activity of wild type p53 under physiolo... | KEEP AS NON CORE | Summary: p53 has chaperone binding activity related to its folding and stability. Reason: Non-core function related to protein folding and quality control. Supporting Evidence: PMID:15358771 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. |
| GO:0005515 protein binding | IPI PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0003730 mRNA 3'-UTR binding | IDA PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 binds mRNA and regulates gene expression post-transcriptionally. Reason: p53 has RNA-binding activity that contributes to gene regulation. Supporting Evidence: PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0010628 positive regulation of gene expression | IDA PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... | ACCEPT | Summary: p53 positively regulates gene expression of numerous target genes. Reason: Core transcriptional function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism. PMID:20332243 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. |
| GO:0010628 positive regulation of gene expression | IMP PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mi... | ACCEPT | Summary: p53 positively regulates gene expression of numerous target genes. Reason: Core transcriptional function - p53 is a transcriptional activator. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:26100857 A metabolic stress-inducible miR-34a-HNF4Ξ± pathway regulates lipid and lipoprotein metabolism. PMID:20332243 2010 Mar 23. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. PMID:19160485 A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IDA PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0030330 DNA damage response, signal transduction by p53 class mediator | IMP PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 mediates DNA damage response signal transduction as THE p53 class mediator. Reason: Absolutely core function - p53 is the defining member of the p53 class mediator family. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15149599 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0032991 protein-containing complex | IDA PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... | ACCEPT | Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators. Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. |
| GO:0034644 cellular response to UV | IDA PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 responds to UV-induced DNA damage as part of its DNA damage response. Reason: Core function - UV radiation is a classic p53-activating stress. Supporting Evidence: GO:0009411 response to UV PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IMP PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0071480 cellular response to gamma radiation | IDA PMID:16213212 Regulation of p53 translation and induction after DNA damage... | ACCEPT | Summary: p53 responds to gamma radiation-induced DNA damage. Reason: Core function - ionizing radiation is a classic p53 activator. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md gamma radiation causes DNA damage that strongly activates p53 PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. |
| GO:0072331 signal transduction by p53 class mediator | IDA PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... | ACCEPT | Summary: p53 IS the p53 class mediator that transduces signals in response to stress. Reason: Absolutely core function - this term specifically describes p53's central role in stress signaling. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 coordinates cellular responses to diverse stress signals PMID:25384516 Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:29681526 A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity. PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator | IMP PMID:17310983 Ribosomal protein S7 as a novel modulator of p53-MDM2 intera... | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation. Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. |
| GO:0072717 cellular response to actinomycin D | IDA PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 funct... | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling in response to DNA damage. Reason: Core function - DNA damage-induced apoptosis is a major p53 mechanism. Supporting Evidence: GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PMID:15314173 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. |
| GO:0005515 protein binding | IPI PMID:25591766 RNF125 is a ubiquitin-protein ligase that promotes p53 degra... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:25591766 RNF125 is a ubiquitin-protein ligase that promotes p53 degradation. |
| GO:0002039 p53 binding | IPI PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. | ACCEPT | Summary: p53 is a substrate of p21 (CDKN1A), creating a regulatory feedback loop. Reason: Regulatory interaction - p21 is both a target and regulator of p53. Supporting Evidence: PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. |
| GO:0006355 regulation of DNA-templated transcription | IMP PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. | ACCEPT | Summary: p53 regulates DNA-templated transcription as both an activator and repressor. Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0003677 DNA binding | IMP PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. | ACCEPT | Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements. Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops PMID:15358771 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:2144364 Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. |
| GO:0032991 protein-containing complex | IMP PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. | ACCEPT | Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators. Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. |
| GO:0097718 disordered domain specific binding | IPI PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. | KEEP AS NON CORE | Summary: p53 is involved in dimerization of proteins. Reason: Non-core - while p53 dimerizes, this is covered by more specific tetramerization terms. Supporting Evidence: PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. |
| GO:0000785 chromatin | IDA PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0005737 cytoplasm | IDA PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0006914 autophagy | IMP PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 regulates autophagy both positively and negatively depending on context. Reason: p53 regulates autophagy as part of cellular stress response. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 also regulates autophagy PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. |
| GO:0042826 histone deacetylase binding | IPI PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 undergoes deacetylation as part of its regulatory cycle. Reason: Core regulatory mechanism - p53 acetylation/deacetylation cycle regulates its activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md C-terminal acetylation regulates p53 activity PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. |
| GO:0045892 negative regulation of DNA-templated transcription | IMP PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf ex... | ACCEPT | Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes. Reason: Core function - p53 acts as both a transcriptional activator and repressor. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mechanism. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
| GO:0005515 protein binding | IPI PMID:17237821 Transcription factor TAFII250 promotes Mdm2-dependent turnov... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17237821 Jan 22. Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. |
| GO:0005634 nucleus | IDA PMID:24289924 Phosphorylation of p53 by TAF1 inactivates p53-dependent tra... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5689950 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5689973 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5690843 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-6793685 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8852351 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8852354 | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005515 protein binding | IPI PMID:10597287 Molecular interactions between telomerase and the tumor supp... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10597287 Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222116 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222237 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5628871 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805638 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805730 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805740 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805755 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6811508 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805276 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805399 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805103 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805109 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805126 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3215310 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6793685 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804441 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804879 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805059 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8852337 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8852351 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851077 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804383 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3215152 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3215251 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222093 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222128 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3700981 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3700997 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4331331 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4331340 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5633295 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5633414 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791285 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791302 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791327 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791349 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791387 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6796649 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6797766 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6797993 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798020 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798082 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798129 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798138 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798282 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798304 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798374 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799246 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799409 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799418 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799462 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799761 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799777 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799815 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6800042 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6800253 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6800279 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6800836 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6801087 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6801166 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6801209 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6801355 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6801641 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6802165 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803391 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803425 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803719 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803801 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803858 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803914 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6803935 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804191 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804242 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804379 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804402 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804425 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805122 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805285 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805620 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6806408 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6806412 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6806413 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6806417 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6806419 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6811479 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-69685 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9710323 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9749464 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9851076 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6798615 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005515 protein binding | IPI PMID:12730672 Physical and functional interaction between HCV core protein... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. |
| GO:0008285 negative regulation of cell population proliferation | IMP PMID:12730672 Physical and functional interaction between HCV core protein... | ACCEPT | Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism. Reason: Core function - p53 inhibits proliferation through cell cycle arrest. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. |
| GO:1900119 positive regulation of execution phase of apoptosis | IMP PMID:14985081 Hepatitis C virus core protein interacts with p53-binding pr... | ACCEPT | Summary: p53 positively regulates intrinsic apoptotic signaling in response to ER stress. Reason: p53 responds to ER stress and can induce apoptosis under severe ER stress. Supporting Evidence: PMID:14985081 Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. |
| GO:0043153 entrainment of circadian clock by photoperiod | ISS GO_REF:0000024 | ACCEPT | Summary: p53 enters the nucleus to function as a transcription factor. Reason: Core process - nuclear entry is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Nuclear Localization Signals (NLS): Function: Nuclear import and localization |
| GO:0045892 negative regulation of DNA-templated transcription | IDA PMID:24051492 p53 regulates Period2 expression and the circadian clock. | ACCEPT | Summary: p53 negatively regulates transcription of various target genes including anti-apoptotic and cell cycle genes. Reason: Core function - p53 acts as both a transcriptional activator and repressor. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:16492744 Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. PMID:9271120 Repression of p53-mediated transcription by MDM2: a dual mechanism. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:24051492 p53 regulates Period2 expression and the circadian clock. |
| GO:0048512 circadian behavior | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: p53 is involved in organ development but is not essential for development. Reason: Non-core developmental function - p53 knockout mice develop normally. |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IDA PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... | ACCEPT | Summary: p53 is a DNA-binding transcription factor that regulates RNA polymerase II transcription of target genes. Reason: Core molecular function - p53 is a well-characterized sequence-specific transcription factor for RNA pol II. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:34381247 Epub 2021 Aug 11. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect. PMID:35618207 Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates. PMID:36634798 Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates. PMID:38653238 2024 Apr 22. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:24652652 DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0005634 nucleus | IDA PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005739 mitochondrion | IDA PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... | ACCEPT | Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation. Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins PMID:25168243 Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
| GO:0005829 cytosol | IDA PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 ... | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0005634 nucleus | IDA PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0006974 DNA damage response | IDA PMID:17938203 Protein kinase C delta induces transcription of the TP53 tum... | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0046677 response to antibiotic | IEP PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... | ACCEPT | Summary: p53 responds to antibiotic stress that causes cellular stress or DNA damage. Reason: p53 responds to various xenobiotic stresses including antibiotics. Supporting Evidence: PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. |
| GO:0071456 cellular response to hypoxia | IEP PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... | ACCEPT | Summary: p53 mediates cellular responses to hypoxia, including cell cycle arrest and apoptosis induction. Reason: Core stress response function - p53 responds to hypoxic stress and coordinates appropriate cellular responses. Supporting Evidence: GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. |
| GO:0090200 positive regulation of release of cytochrome c from mitochondria | IDA PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... | ACCEPT | Summary: p53 positively regulates mitochondrial DNA replication through its DNA repair functions. Reason: p53 maintains mitochondrial genome stability through various mechanisms. Supporting Evidence: PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:2001244 positive regulation of intrinsic apoptotic signaling pathway | IMP PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... | ACCEPT | Summary: p53 negatively regulates intrinsic apoptotic signaling in certain contexts. Reason: p53 can have context-dependent anti-apoptotic effects through p21-mediated survival. Supporting Evidence: PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator | IMP PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation. Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222259 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3239014 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005515 protein binding | IPI PMID:17719541 Hzf Determines cell survival upon genotoxic stress by modula... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-264435 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3221982 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222006 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3222020 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3786258 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4395236 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4647593 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5628899 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5629187 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5632759 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5632887 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5632914 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5632939 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5633460 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5693609 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6789960 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6791409 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799332 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6799431 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804188 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804762 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804996 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6804998 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805035 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805470 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6805479 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8853911 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8952128 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-992753 | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0097252 oligodendrocyte apoptotic process | IDA PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... | ACCEPT | Summary: p53 undergoes various post-translational modifications in response to stress. Reason: Core regulatory mechanism - p53 is extensively modified at over 60 residues. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 can be modified at over 60 of its 393 residues PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005515 protein binding | IPI PMID:22945289 ZNF385B is characteristically expressed in germinal center B... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:22945289 Oct 16. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy met... | ACCEPT | Summary: p53 positively regulates DNA-templated transcription of target genes. Reason: Core transcriptional function - p53 activates transcription of numerous target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0008285 negative regulation of cell population proliferation | IDA PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-typ... | ACCEPT | Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism. Reason: Core function - p53 inhibits proliferation through cell cycle arrest. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. |
| GO:0005515 protein binding | IPI PMID:23431171 MOZ increases p53 acetylation and premature senescence throu... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML. |
| GO:0016605 PML body | IDA PMID:22869143 BMK1 is involved in the regulation of p53 through disrupting... | ACCEPT | Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation. Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 localizes to nuclear bodies like PML bodies, especially during stress responses PMID:22869143 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:20124405 G-protein-coupled receptor kinase 5 phosphorylates p53 and i... | ACCEPT | Summary: p53 can negatively regulate apoptosis in certain contexts through p21-mediated survival. Reason: Context-dependent function - p53 can promote survival under mild stress conditions. Supporting Evidence: PMID:20124405 2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis. |
| GO:0016032 viral process | IMP PMID:22574148 p53 Activation following Rift Valley fever virus infection c... | KEEP AS NON CORE | Summary: p53 is involved in viral processes through its antiviral functions. Reason: Non-core function - p53 has antiviral activity but this is not its primary role. Supporting Evidence: PMID:22574148 p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. |
| GO:0000785 chromatin | IDA PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D t... | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0030971 receptor tyrosine kinase binding | IPI PMID:23027130 TrkC signaling is activated in adenoid cystic carcinoma and ... | ACCEPT | Summary: p53 interacts with receptor tyrosine kinases as part of signal transduction. Reason: p53 integrates signals from growth factor signaling pathways. Supporting Evidence: PMID:23027130 TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. |
| GO:0005515 protein binding | IPI PMID:19483087 Identification and characterization of two novel isoforms of... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19483087 Epub 2009 May 29. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. |
| GO:0005515 protein binding | IPI PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0005829 cytosol | IDA PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membr... | ACCEPT | Summary: p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling. Reason: p53 shuttles between nucleus and cytoplasm, with cytosolic localization important for regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. |
| GO:0000785 chromatin | IDA PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0005515 protein binding | IPI PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0006974 DNA damage response | IDA PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcr... | ACCEPT | Summary: p53 is central to the DNA damage response, being activated by and coordinating responses to DNA damage. Reason: Core function - p53 is the 'guardian of the genome' that coordinates DNA damage responses. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 serves as a central node in the DNA damage response network PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17938203 Oct 15. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. |
| GO:0048147 negative regulation of fibroblast proliferation | IMP PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of norm... | KEEP AS NON CORE | Summary: p53 negatively regulates fibroblast proliferation as part of its anti-proliferative function. Reason: Cell type-specific manifestation of anti-proliferative function. Supporting Evidence: PMID:10962037 Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. |
| GO:0005515 protein binding | IPI PMID:20123734 NIR, an inhibitor of histone acetyltransferases, regulates t... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20123734 Jan 31. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. |
| GO:0005515 protein binding | IPI PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... | ACCEPT | Summary: p53 positively regulates apoptosis as a major tumor suppressor mechanism. Reason: Core function - p53 induces apoptosis through multiple pathways. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. PMID:15565177 A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylat... | ACCEPT | Summary: p53 is a sequence-specific transcriptional activator that upregulates target genes including p21, PUMA, BAX. Reason: Fundamental molecular function - p53 activates transcription of numerous target genes through binding to p53 response elements. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16061649 Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. PMID:11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. PMID:17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. PMID:17146433 Dec 4. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:24356969 2013 Dec 19. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:24652652 2014 Mar 20. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. PMID:20959462 2010 Oct 19. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. |
| GO:0003682 chromatin binding | IDA PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | ACCEPT | Summary: p53 binds chromatin at p53 response elements in target gene promoters. Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation. Supporting Evidence: PDB:3TS8 Crystal structure of p53 tetramer bound to DNA PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:16322561 NIR is a novel INHAT repressor that modulates the transcript... | ACCEPT | Summary: p53 positively regulates DNA-templated transcription of target genes. Reason: Core transcriptional function - p53 activates transcription of numerous target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0005515 protein binding | IPI PMID:20124405 G-protein-coupled receptor kinase 5 phosphorylates p53 and i... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20124405 2010 Feb 2. G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis. |
| GO:0042149 cellular response to glucose starvation | IDA PMID:21471221 Novel nucleolar pathway connecting intracellular energy stat... | ACCEPT | Summary: p53 responds to glucose starvation as part of metabolic stress response. Reason: p53 responds to metabolic stress including glucose deprivation. Supporting Evidence: PMID:21471221 2011 Apr 6. Novel nucleolar pathway connecting intracellular energy status with p53 activation. |
| GO:0005634 nucleus | IDA PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabiliz... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts wi... | ACCEPT | Summary: p53 binds RNA through its C-terminal domain. Reason: p53 has RNA-binding activity that contributes to regulation of gene expression. Supporting Evidence: PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. |
| GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator | IMP PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis i... | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling through BAX, PUMA, NOXA activation. Reason: Core apoptotic function - p53 is the master regulator of intrinsic apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:12172011 Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. |
| GO:0000785 chromatin | IDA PMID:17805299 p53 is regulated by the lysine demethylase LSD1. | ACCEPT | Summary: p53 associates with chromatin at target gene promoters to regulate transcription. Reason: Core molecular function - p53 binds to chromatin at p53 response elements to regulate target gene expression. Supporting Evidence: PDB:3TS8 Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:30089260 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:22521434 Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. PMID:15710329 Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0019899 enzyme binding | IPI PMID:17805299 p53 is regulated by the lysine demethylase LSD1. | REMOVE | Summary: Generic 'enzyme binding' is uninformative for p53 function. Reason: Too generic - p53 binds many enzymes but this term provides no functional insight. Supporting Evidence: PMID:17805299 p53 is regulated by the lysine demethylase LSD1. |
| GO:0071466 cellular response to xenobiotic stimulus | IEP PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances... | ACCEPT | Summary: p53 mediates cellular response to xenobiotic stress. Reason: p53 responds to various xenobiotic stresses that cause DNA damage or cellular stress. Supporting Evidence: PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. |
| GO:2000379 positive regulation of reactive oxygen species metabolic process | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | ACCEPT | Summary: p53 positively regulates intrinsic apoptotic signaling in response to DNA damage. Reason: Core function - DNA damage-induced apoptosis is a primary p53 tumor suppressor mechanism. Supporting Evidence: GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. |
| GO:0005737 cytoplasm | IDA PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0008285 negative regulation of cell population proliferation | ISS GO_REF:0000024 | ACCEPT | Summary: p53 negatively regulates cell proliferation as a fundamental tumor suppressor mechanism. Reason: Core function - p53 inhibits proliferation through cell cycle arrest. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division PMID:30514107 CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. PMID:12730672 Physical and functional interaction between HCV core protein and the different p73 isoforms. PMID:22783376 Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. |
| GO:0008340 determination of adult lifespan | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: p53 may influence lifespan through its regulation of senescence and apoptosis. Reason: Non-core function - while p53 influences aging, this is secondary to its tumor suppressor function. |
| GO:0070245 positive regulation of thymocyte apoptotic process | ISS GO_REF:0000024 | ACCEPT | Summary: p53 responds to positive regulation by stress-induced post-translational modifications. Reason: p53 is regulated by extensive post-translational modifications that enhance its activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 can be modified at over 60 of its 393 residues |
| GO:0005515 protein binding | IPI PMID:17707234 Modulation of p53 function by SET8-mediated methylation at l... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17707234 Modulation of p53 function by SET8-mediated methylation at lysine 382. |
| GO:0005515 protein binding | IPI PMID:20118233 G9a and Glp methylate lysine 373 in the tumor suppressor p53... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:20118233 2010 Jan 29. G9a and Glp methylate lysine 373 in the tumor suppressor p53. |
| GO:0090399 replicative senescence | IMP PMID:19951988 WNT16B is a new marker of cellular senescence that regulates... | ACCEPT | Summary: p53 is stabilized and activated under stress conditions. Reason: Core mechanism - p53 protein stabilization is essential for its tumor suppressor function. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 is activated through post-translational modifications which stabilize the protein PMID:19951988 WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. |
| GO:0090403 oxidative stress-induced premature senescence | IMP PMID:19951988 WNT16B is a new marker of cellular senescence that regulates... | ACCEPT | Summary: p53 induces oxidative stress during apoptosis induction. Reason: p53 regulates cellular redox and can promote ROS production in apoptosis. Supporting Evidence: PMID:19951988 WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. |
| GO:0005634 nucleus | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005634 nucleus | IDA PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... | ACCEPT | Summary: p53 is THE p53 class mediator that induces intrinsic apoptosis in response to DNA damage through BAX, PUMA, NOXA activation. Reason: Absolutely core function - this term specifically describes p53's role as the central mediator of DNA damage-induced apoptosis. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Transcriptional: Activation of pro-apoptotic genes (PUMA, BAX, NOXA, FAS) PMID:14654789 A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:16213212 Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for... | ACCEPT | Summary: p53 positively regulates DNA-templated transcription of target genes. Reason: Core transcriptional function - p53 activates transcription of numerous target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0071479 cellular response to ionizing radiation | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | ACCEPT | Summary: p53 responds to UV-A radiation-induced DNA damage. Reason: Core DNA damage response function - UV radiation is a classic p53 activator. Supporting Evidence: GO:0009411 response to UV PMID:20160708 Feedback between p21 and reactive oxygen production is necessary for cell senescence. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | ISS PMID:19749791 Repression of SHP-1 expression by p53 leads to trkA tyrosine... | ACCEPT | Summary: p53 functions as a transcriptional repressor for genes including BCL2 and cell cycle genes. Reason: Core function - transcriptional repression is part of p53's regulatory activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Repression: Downregulates anti-apoptotic genes (BCL2), cell cycle progression genes PMID:10329733 p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. PMID:19749791 Sep 14. Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. |
| GO:0002020 protease binding | IPI PMID:11923872 Deubiquitination of p53 by HAUSP is an important pathway for... | ACCEPT | Summary: p53 binds protease inhibitors as part of regulatory interactions. Reason: Regulatory protein-protein interaction. Supporting Evidence: PMID:11923872 Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor sup... | REMOVE | Summary: Generic 'ubiquitin protein ligase binding' is less informative than specific MDM2/MDM4 interactions. Reason: While p53 binds MDM2 (E3 ligase), this generic term is uninformative. The specific MDM2 interaction is well-documented elsewhere. Supporting Evidence: PMID:8875929 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. |
| GO:0051721 protein phosphatase 2A binding | IPI PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA d... | ACCEPT | Summary: p53 interacts with tubulin during mitosis and cell division control. Reason: p53 regulates cell division and can interact with cytoskeletal components. Supporting Evidence: PMID:17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. |
| GO:0005634 nucleus | IDA PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:20096447 USP10 regulates p53 localization and stability by deubiquiti... | ACCEPT | Summary: p53 positively regulates DNA-templated transcription of target genes. Reason: Core transcriptional function - p53 activates transcription of numerous target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:20378837 Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. |
| GO:0032991 protein-containing complex | IDA PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a ... | ACCEPT | Summary: p53 forms part of protein-containing complexes including the p53 tetramer and complexes with co-activators. Reason: p53 functions in complexes with CBP/p300, MDM2, and forms tetramers. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:17310983 Feb 19. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:9529249 ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. |
| GO:0007265 Ras protein signal transduction | IEP PMID:9054499 Oncogenic ras provokes premature cell senescence associated ... | ACCEPT | Summary: p53 is regulated by Ras signaling pathway which can activate p53. Reason: p53 is activated by oncogenic Ras signaling as a tumor suppressor mechanism. Supporting Evidence: PMID:9054499 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. |
| GO:0005634 nucleus | IDA PMID:18756595 Prognostic significance of BMP and activin membrane-bound in... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0010332 response to gamma radiation | IMP PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... | ACCEPT | Summary: p53 responds to gamma radiation-induced DNA damage. Reason: Core function - ionizing radiation strongly activates p53. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 responds to DNA damage from ionizing radiation PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0031571 mitotic G1 DNA damage checkpoint signaling | IMP PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and ... | ACCEPT | Summary: p53 mediates G1 DNA damage checkpoint signaling through p21 induction. Reason: Core function - G1/S checkpoint is a major p53-mediated cell cycle control. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Cell cycle arrest is mediated by transcriptional upregulation of p21 PMID:7958916 DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. |
| GO:0005515 protein binding | IPI PMID:17317671 The notch regulator MAML1 interacts with p53 and functions a... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:17317671 2007 Feb 22. The notch regulator MAML1 interacts with p53 and functions as a coactivator. |
| GO:0005515 protein binding | IPI PMID:19151705 CHD8 suppresses p53-mediated apoptosis through histone H1 re... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:19151705 CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. |
| GO:0008270 zinc ion binding | TAS PMID:10065153 Covalent and noncovalent modifiers of the p53 protein. | ACCEPT | Summary: p53 DNA-binding domain coordinates a zinc ion essential for structural stability. Reason: Core structural feature - zinc coordination is essential for p53 DNA-binding domain structure. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA-Binding Domain contains critical zinc coordination site PMID:10065153 Covalent and noncovalent modifiers of the p53 protein. |
| GO:0016605 PML body | IDA PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced ... | ACCEPT | Summary: p53 localizes to PML nuclear bodies, which is important for its post-translational modification and activation. Reason: Important regulatory localization - p53 accumulates in PML bodies during stress responses where it undergoes acetylation. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md p53 localizes to nuclear bodies like PML bodies, especially during stress responses PMID:22869143 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. PMID:12006491 Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
| GO:0051087 protein-folding chaperone binding | IPI PMID:18086682 Hsp60 regulation of tumor cell apoptosis. | KEEP AS NON CORE | Summary: p53 has chaperone binding activity related to its folding and stability. Reason: Non-core function related to protein folding and quality control. Supporting Evidence: PMID:18086682 2007 Dec 17. Hsp60 regulation of tumor cell apoptosis. |
| GO:0003682 chromatin binding | IDA PMID:17599062 CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediate... | ACCEPT | Summary: p53 binds chromatin at p53 response elements in target gene promoters. Reason: Core molecular function - chromatin binding is essential for p53's transcriptional regulation. Supporting Evidence: PDB:3TS8 Crystal structure of p53 tetramer bound to DNA PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:17599062 Jun 28. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. |
| GO:0097193 intrinsic apoptotic signaling pathway | TAS PMID:16462759 Inhibition of Bax activity is crucial for the antiapoptotic ... | ACCEPT | Summary: p53 mediates intrinsic apoptotic signaling through mitochondrial pathway activation. Reason: Core function - intrinsic apoptotic signaling is a major p53 tumor suppressor mechanism. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Apoptosis induction seems to be mediated either by stimulation of BAX PMID:16462759 Feb 6. Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein. |
| GO:0005634 nucleus | IDA PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival p... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0008104 intracellular protein localization | IDA PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival p... | ACCEPT | Summary: p53 localization is regulated by nuclear import and export mechanisms. Reason: Core regulatory mechanism - nucleo-cytoplasmic shuttling regulates p53 activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Nuclear Localization Signals (NLS): Function: Nuclear import and localization PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. |
| GO:0046982 protein heterodimerization activity | IPI PMID:10837489 MCL-1S, a splicing variant of the antiapoptotic BCL-2 family... | ACCEPT | Summary: p53 binds to hetero-dimeric protein partners as part of its regulatory function. Reason: p53 forms heterodimers with various regulatory proteins. Supporting Evidence: PMID:10837489 MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. |
| GO:0005515 protein binding | IPI PMID:15735003 p53CSV, a novel p53-inducible gene involved in the p53-depen... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:15735003 p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. |
| GO:0005515 protein binding | IPI PMID:11861836 Human immunodeficiency virus type 1 Nef binds to tumor suppr... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11861836 Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. |
| GO:0005515 protein binding | IPI PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0005654 nucleoplasm | IDA PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... | ACCEPT | Summary: p53 is a nuclear transcription factor that localizes to the nucleoplasm. Reason: Core cellular localization - p53 functions as a transcription factor in the nucleoplasm. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0016363 nuclear matrix | IDA PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific P... | ACCEPT | Summary: p53 regulates nuclear matrix organization. Reason: p53 interacts with nuclear matrix components and influences nuclear organization. Supporting Evidence: PMID:11080164 Regulation of p53 activity in nuclear bodies by a specific PML isoform. |
| GO:0065003 protein-containing complex assembly | IDA PMID:12915590 Cellular stress and DNA damage invoke temporally distinct Md... | ACCEPT | Summary: p53 forms protein-containing complexes with transcriptional machinery and regulators. Reason: Core function - p53 assembles into functional complexes to regulate transcription. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Complex formation with transcriptional co-activators (CBP/p300, TFIID) PMID:12915590 Aug 12. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. |
| GO:0005515 protein binding | IPI PMID:11684014 ASPP proteins specifically stimulate the apoptotic function ... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:11684014 ASPP proteins specifically stimulate the apoptotic function of p53. |
| GO:0005515 protein binding | IPI PMID:8675009 The XPB and XPD DNA helicases are components of the p53-medi... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:8675009 The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. |
| GO:0005515 protein binding | IPI PMID:10608892 Stabilization of the MDM2 oncoprotein by interaction with th... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:10608892 Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. |
| GO:0005515 protein binding | IPI PMID:12750254 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 ac... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:12750254 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. |
| GO:0051097 negative regulation of helicase activity | TAS PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... | ACCEPT | Summary: p53 inhibits helicase activity as part of DNA repair regulation. Reason: p53 can regulate DNA repair processes including helicase activity during damage response. Supporting Evidence: PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repair activity. |
| GO:0006289 nucleotide-excision repair | IMP PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repai... | ACCEPT | Summary: p53 promotes nucleotide-excision repair (NER) through transcriptional regulation of XPC and DDB2. Reason: Core DNA repair function - p53 regulates multiple DNA repair genes including those in the NER pathway. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA Repair: XPC: Nucleotide excision repair; DDB2: DNA damage-binding protein PMID:7663514 p53 modulation of TFIIH-associated nucleotide excision repair activity. |
| GO:0005515 protein binding | IPI PMID:1465435 Wild-type p53 binds to the TATA-binding protein and represse... | REMOVE | Summary: Generic 'protein binding' term provides no functional information about p53's specific protein-protein interactions with MDM2, TFIID, CBP/p300, etc. Reason: The term 'protein binding' is uninformative and should be removed per GO curation guidelines. p53 has many well-characterized functional protein interactions (MDM2, CBP/p300, TFIID, etc.) that are better represented by more specific terms. Supporting Evidence: PMID:1465435 Wild-type p53 binds to the TATA-binding protein and represses transcription. |
| GO:0005739 mitochondrion | IDA PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. | ACCEPT | Summary: p53 translocates to mitochondria to directly promote apoptosis through BAX activation. Reason: Important localization for non-transcriptional apoptosis - p53 can directly induce MOMP at mitochondria. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md Non-transcriptional: Direct mitochondrial translocation and interaction with BCL-2 family proteins PMID:25168243 Aug 29. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:12667443 p53 has a direct apoptogenic role at the mitochondria. |
| GO:0005507 copper ion binding | IDA PMID:7824276 Modulation by copper of p53 conformation and sequence-specif... | ACCEPT | Summary: p53 DNA-binding domain binds copper ions which can affect its function. Reason: Structural feature - copper binding can affect p53 structure and function. Supporting Evidence: PMID:7824276 Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism. |
| GO:0030308 negative regulation of cell growth | IMP PMID:8986812 Identification of a novel p53 functional domain that is nece... | ACCEPT | Summary: p53 negatively regulates cell growth as a fundamental tumor suppressor mechanism. Reason: Core function - growth inhibition is a primary tumor suppressor activity of p53. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Negatively regulates cell division by controlling expression of a set of genes required for this process PMID:8986812 Identification of a novel p53 functional domain that is necessary for efficient growth suppression. |
| GO:0005634 nucleus | IDA PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... | ACCEPT | Summary: p53 is primarily a nuclear transcription factor, with nuclear localization essential for its function. Reason: Core cellular component - p53's nuclear localization is essential for its transcription factor activity. Contains nuclear localization signals at residues 305-322 and 369-375. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. PMID:14963330 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. PMID:16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. PMID:36108750 Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:24289924 Nov 27. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. PMID:24101517 Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:19234109 Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:17403783 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:18756595 Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. PMID:16507995 Myosin VI is a mediator of the p53-dependent cell survival pathway. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0005737 cytoplasm | IDA PMID:7720704 Direct involvement of p53 in programmed cell death of oligod... | ACCEPT | Summary: p53 localizes to cytoplasm as well as nucleus, with cytoplasmic localization important for regulation. Reason: Core cellular component - p53 shuttles between nucleus and cytoplasm, with cytoplasmic localization important for MDM2-mediated regulation. Supporting Evidence: file:human/TP53/TP53-uniprot.txt SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PMID:24625977 Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. PMID:26634371 Epub 2015 Dec 4. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. PMID:21597459 2011 May 20. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. PMID:19011621 Arginine methylation regulates the p53 response. PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:23629966 Deacetylation of p53 induces autophagy by suppressing Bmf expression. PMID:20810912 Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. PMID:16131611 p53 isoforms can regulate p53 transcriptional activity. PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. PMID:20096447 USP10 regulates p53 localization and stability by deubiquitinating p53. PMID:7720704 Direct involvement of p53 in programmed cell death of oligodendrocytes. |
| GO:0003677 DNA binding | IMP PMID:2144364 Transcriptional activation by wild-type but not transforming... | ACCEPT | Summary: p53 binds DNA through its central DNA-binding domain (residues 102-292) to p53 response elements. Reason: Core molecular function - DNA binding is essential for p53's transcription factor activity. Supporting Evidence: file:human/TP53/TP53-deep-research-manual.md DNA-Binding Domain (DBD): Location: Residues 102-292; Structure: beta-sandwich core with DNA-binding loops PMID:15358771 2004 Sep 9. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. PMID:15629713 Binding of natively unfolded HIF-1alpha ODD domain to p53. PMID:2144364 Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. |
| GO:0003700 DNA-binding transcription factor activity | IDA PMID:7587074 Targets for transcriptional activation by wild-type p53: end... | ACCEPT | Summary: p53 is a well-characterized DNA-binding transcription factor that activates and represses target genes. Reason: Core molecular function - p53 is one of the best-characterized transcription factors, regulating >500 target genes. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:16479015 Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. PMID:26334721 2015 Sep 3. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. PMID:18549481 TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
| GO:0005730 nucleolus | IDA PMID:12080348 Nucleophosmin regulates the stability and transcriptional ac... | ACCEPT | Summary: p53 localizes to nucleolus, particularly during stress responses and ribosome biogenesis regulation. Reason: p53 can localize to nucleolus and regulate ribosomal biogenesis as part of stress response. Supporting Evidence: PMID:12080348 Nucleophosmin regulates the stability and transcriptional activity of p53. |
| GO:0006355 regulation of DNA-templated transcription | IDA PMID:7587074 Targets for transcriptional activation by wild-type p53: end... | ACCEPT | Summary: p53 regulates DNA-templated transcription as both an activator and repressor. Reason: Core molecular function - transcription regulation is fundamental to p53's tumor suppressor activity. Supporting Evidence: file:human/TP53/TP53-uniprot.txt Multifunctional transcription factor PMID:25417702 Functional interplay between MDM2, p63/p73 and mutant p53. PMID:7587074 Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. |
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Download this section (compressed HTML)Q: How does p53 integrate diverse stress signals to determine cell fate decisions between survival, senescence, and apoptosis?
Q: What determines the selectivity of p53 for different target gene promoters and how is this modulated by post-translational modifications?
Q: How do p53 isoforms and mutant forms interact to modulate tumor suppressor function in heterozygous cancer cells?
Experiment: Single-cell time-lapse imaging to track p53 dynamics and correlate oscillation patterns with specific cell fate outcomes
Experiment: ChIP-seq coupled with PRO-seq to map p53 binding and transcriptional outcomes under different stress conditions
Experiment: Proximity labeling proteomics to identify context-specific p53 interactors that determine target gene selectivity
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