TRAF2 is a cytoplasmic adaptor that organizes TNF receptor superfamily signaling complexes. Its C-terminal TRAF region engages receptors and associated proteins, while oligomerization and recruitment of cIAP ubiquitin ligases connect receptor activation to NF-kappaB, MAP kinase signaling and regulation of cell survival. TRAF2 also participates in selected immune-receptor and ER-stress signaling assemblies. Intrinsic ubiquitin-ligase activity has been reported in cofactor-dependent assays but remains mechanistically contested.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000151 ubiquitin ligase complex | IPI PMID:17314283 Parkin mediates neuroprotection through activation of Ikappa... | ACCEPT | Summary: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Reason: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0000151 ubiquitin ligase complex | IPI PMID:29581234 TRAF-interacting protein with forkhead-associated domain (TI... | ACCEPT | Summary: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Reason: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0002224 toll-like receptor signaling pathway | IDA PMID:26458771 Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis thro... | UNDECIDED | Summary: The full text assays TRAF2-driven NF-kappaB as a TNFR2 comparison and explicitly contrasts it with TLR/TRAF6 signaling. This supports TRAF2-dependent NF-kappaB activity but does not directly resolve the broader TLR-pathway annotation. The specific annotation should be traced without assuming absence of all TRAF2 involvement in TLR biology. Reason: The full text assays TRAF2-driven NF-kappaB as a TNFR2 comparison and explicitly contrasts it with TLR/TRAF6 signaling. This supports TRAF2-dependent NF-kappaB activity but does not directly resolve the broader TLR-pathway annotation. The specific annotation should be traced without assuming absence of all TRAF2 involvement in TLR biology. Supporting Evidence: PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0002700 regulation of production of molecular mediator of immune response | IEA GO_REF:0000117 | ACCEPT | Summary: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Reason: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0002726 positive regulation of T cell cytokine production | IMP PMID:15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activ... | ACCEPT | Summary: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Reason: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0002947 tumor necrosis factor receptor superfamily complex | IDA PMID:23429285 EVER2 protein binds TRADD to promote TNF-Ξ±-induced apoptosis... | ACCEPT | Summary: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Reason: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0002947 tumor necrosis factor receptor superfamily complex | NAS PMID:15861135 TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ub... | ACCEPT | Summary: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Reason: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0002947 tumor necrosis factor receptor superfamily complex | NAS PMID:36179048 Novel biochemical, structural, and systems insights into inf... | ACCEPT | Summary: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Reason: TRAF2 recruits cIAP1/2 into TNF receptor signaling assemblies. Reconstituted binding supports membership in a ubiquitin-ligase-containing complex without requiring TRAF2 itself to supply the E3 catalytic activity. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0004842 ubiquitin-protein transferase activity | EXP PMID:26620909 Reversible ubiquitination shapes NLRC5 function and modulate... | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0004842 ubiquitin-protein transferase activity | IBA GO_REF:0000033 | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0004842 ubiquitin-protein transferase activity | IDA PMID:15258597 De-ubiquitination and ubiquitin ligase domains of A20 downre... | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0004842 ubiquitin-protein transferase activity | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0004842 ubiquitin-protein transferase activity | IEA GO_REF:0000002 | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0005164 tumor necrosis factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IEA GO_REF:0000002 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11728344 A novel TNF receptor family member binds TWEAK and is implic... | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005174 CD40 receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005174 CD40 receptor binding | ISS GO_REF:0000024 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005515 protein binding | IPI PMID:10075662 Activation of NF-kappaB by RANK requires tumor necrosis fact... | UNDECIDED | Summary: The PMID:10075662 interaction assertion for partner(s) UniProtKB:Q9Y6Q6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10075662 interaction assertion for partner(s) UniProtKB:Q9Y6Q6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:10514511 TRAF family proteins interact with the common neurotrophin r... | UNDECIDED | Summary: The PMID:10514511 interaction assertion for partner(s) UniProtKB:P07174 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10514511 interaction assertion for partner(s) UniProtKB:P07174 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:10518213 The structural basis for the recognition of diverse receptor... | UNDECIDED | Summary: The PMID:10518213 interaction assertion for partner(s) UniProtKB:P20334 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10518213 interaction assertion for partner(s) UniProtKB:P20334 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:10518213 The structural basis for the recognition of diverse receptor... | UNDECIDED | Summary: The PMID:10518213 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10518213 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:10521462 TNIK, a novel member of the germinal center kinase family th... | UNDECIDED | Summary: The PMID:10521462 interaction assertion for partner(s) UniProtKB:Q9UKE5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10521462 interaction assertion for partner(s) UniProtKB:Q9UKE5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:10892748 A novel mechanism of TRAF signaling revealed by structural a... | UNDECIDED | Summary: The PMID:10892748 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:10892748 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | UNDECIDED | Summary: The PMID:11278723 interaction assertion for partner(s) UniProtKB:O08736 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11278723 interaction assertion for partner(s) UniProtKB:O08736 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | UNDECIDED | Summary: The PMID:11278723 interaction assertion for partner(s) UniProtKB:O75460 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11278723 interaction assertion for partner(s) UniProtKB:O75460 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | UNDECIDED | Summary: The PMID:11278723 interaction assertion for partner(s) UniProtKB:Q9H2K8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11278723 interaction assertion for partner(s) UniProtKB:Q9H2K8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11466612 Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulate... | UNDECIDED | Summary: The PMID:11466612 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11466612 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11777919 Sphingosine kinase interacts with TRAF2 and dissects tumor n... | UNDECIDED | Summary: The PMID:11777919 interaction assertion for partner(s) UniProtKB:Q9NRA0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11777919 interaction assertion for partner(s) UniProtKB:Q9NRA0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11798190 T2BP, a novel TRAF2 binding protein, can activate NF-kappaB ... | UNDECIDED | Summary: The PMID:11798190 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11798190 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | UNDECIDED | Summary: The PMID:11907583 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11907583 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | UNDECIDED | Summary: The PMID:11907583 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:11907583 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | UNDECIDED | Summary: The PMID:14743216 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:14743216 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | UNDECIDED | Summary: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | UNDECIDED | Summary: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | UNDECIDED | Summary: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | UNDECIDED | Summary: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:14743216 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:15121867 TRAF family proteins link PKR with NF-kappa B activation. | UNDECIDED | Summary: The PMID:15121867 interaction assertion for partner(s) UniProtKB:P19525 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:15121867 interaction assertion for partner(s) UniProtKB:P19525 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P24278 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P24278 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8N2X6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8N2X6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8N9N5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8N9N5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q8TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96EK7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96EK7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96IX9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q96IX9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | UNDECIDED | Summary: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16189514 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16282325 Distinct BIR domains of cIAP1 mediate binding to and ubiquit... | UNDECIDED | Summary: The PMID:16282325 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16282325 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16282325 Distinct BIR domains of cIAP1 mediate binding to and ubiquit... | UNDECIDED | Summary: The PMID:16282325 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16282325 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16311516 The KSHV oncoprotein vFLIP contains a TRAF-interacting motif... | UNDECIDED | Summary: The PMID:16311516 interaction assertion for partner(s) UniProtKB:P88961 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16311516 interaction assertion for partner(s) UniProtKB:P88961 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | KEEP AS NON CORE | Summary: The GSTP1βTRAF2 study directly investigates TRAF2 binding and regulation of ASK1 signaling. The interaction is credible in this context, while the generic binding term alone is not a sufficient core molecular-function summary. Reason: The GSTP1βTRAF2 study directly investigates TRAF2 binding and regulation of ASK1 signaling. The interaction is credible in this context, while the generic binding term alone is not a sufficient core molecular-function summary. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0005515 protein binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | KEEP AS NON CORE | Summary: The GSTP1βTRAF2 study directly investigates TRAF2 binding and regulation of ASK1 signaling. The interaction is credible in this context, while the generic binding term alone is not a sufficient core molecular-function summary. Reason: The GSTP1βTRAF2 study directly investigates TRAF2 binding and regulation of ASK1 signaling. The interaction is credible in this context, while the generic binding term alone is not a sufficient core molecular-function summary. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0005515 protein binding | IPI PMID:16713569 A protein-protein interaction network for human inherited at... | UNDECIDED | Summary: The PMID:16713569 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:16713569 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:17389591 RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site ... | UNDECIDED | Summary: The PMID:17389591 interaction assertion for partner(s) UniProtKB:Q5VWQ8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:17389591 interaction assertion for partner(s) UniProtKB:Q5VWQ8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:19332782 Unconventional ligand activation of herpesvirus entry mediat... | UNDECIDED | Summary: The PMID:19332782 interaction assertion for partner(s) UniProtKB:Q92956 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:19332782 interaction assertion for partner(s) UniProtKB:Q92956 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:19805025 CIB1 functions as a Ca(2+)-sensitive modulator of stress-ind... | UNDECIDED | Summary: The PMID:19805025 interaction assertion for partner(s) UniProtKB:Q99683 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:19805025 interaction assertion for partner(s) UniProtKB:Q99683 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20447407 Asymmetric recruitment of cIAPs by TRAF2. | MODIFY | Summary: The directly characterized TRAF2 interaction recruits a component of receptor signaling machinery. Signaling adaptor activity captures the established role more precisely than generic protein binding. Reason: The directly characterized TRAF2 interaction recruits a component of receptor signaling machinery. Signaling adaptor activity captures the established role more precisely than generic protein binding. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | UNDECIDED | Summary: The PMID:20562859 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20562859 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | UNDECIDED | Summary: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | UNDECIDED | Summary: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | UNDECIDED | Summary: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | UNDECIDED | Summary: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20562859 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20676093 The transmembrane activator TACI triggers immunoglobulin cla... | UNDECIDED | Summary: The PMID:20676093 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20676093 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:20732415 The MYND domain-containing protein BRAM1 inhibits lymphotoxi... | UNDECIDED | Summary: The PMID:20732415 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:20732415 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q8N448 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q8N448 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q9P2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q9P2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | UNDECIDED | Summary: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21516116 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21525013 TWEAK induces apoptosis through a death-signaling complex co... | UNDECIDED | Summary: The PMID:21525013 interaction assertion for partner(s) UniProtKB:Q9NP84 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21525013 interaction assertion for partner(s) UniProtKB:Q9NP84 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21653699 Cellular inhibitor of apoptosis protein-1 (cIAP1) can regula... | UNDECIDED | Summary: The PMID:21653699 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21653699 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21782231 MAVS forms functional prion-like aggregates to activate and ... | UNDECIDED | Summary: The PMID:21782231 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21782231 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21810480 AWP1 binds to tumor necrosis factor receptor-associated fact... | UNDECIDED | Summary: The PMID:21810480 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21810480 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21810480 AWP1 binds to tumor necrosis factor receptor-associated fact... | UNDECIDED | Summary: The PMID:21810480 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21810480 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | UNDECIDED | Summary: The PMID:21903422 interaction assertion for partner(s) UniProtKB:O43353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21903422 interaction assertion for partner(s) UniProtKB:O43353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | UNDECIDED | Summary: The PMID:21903422 interaction assertion for partner(s) UniProtKB:P70191 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21903422 interaction assertion for partner(s) UniProtKB:P70191 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | UNDECIDED | Summary: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | UNDECIDED | Summary: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | UNDECIDED | Summary: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21903422 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | UNDECIDED | Summary: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | UNDECIDED | Summary: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | UNDECIDED | Summary: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:21988832 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:22095282 Arginine methylation-dependent regulation of ASK1 signaling ... | UNDECIDED | Summary: The PMID:22095282 interaction assertion for partner(s) UniProtKB:Q99683 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:22095282 interaction assertion for partner(s) UniProtKB:Q99683 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:22904686 The germinal center kinase TNIK is required for canonical NF... | UNDECIDED | Summary: The PMID:22904686 interaction assertion for partner(s) UniProtKB:Q9UKE5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:22904686 interaction assertion for partner(s) UniProtKB:Q9UKE5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23088713 Protein interactions of the transcription factor Hoxa1. | UNDECIDED | Summary: The PMID:23088713 interaction assertion for partner(s) UniProtKB:P09022 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23088713 interaction assertion for partner(s) UniProtKB:P09022 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23332158 NleB, a bacterial effector with glycosyltransferase activity... | UNDECIDED | Summary: The PMID:23332158 interaction assertion for partner(s) UniProtKB:P04406 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23332158 interaction assertion for partner(s) UniProtKB:P04406 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23524849 OTUB1 modulates c-IAP1 stability to regulate signalling path... | UNDECIDED | Summary: The PMID:23524849 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23524849 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23524849 OTUB1 modulates c-IAP1 stability to regulate signalling path... | UNDECIDED | Summary: The PMID:23524849 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23524849 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23890813 Rotavirus NSP1 inhibits interferon induced non-canonical NFΞΊ... | UNDECIDED | Summary: The PMID:23890813 interaction assertion for partner(s) UniProtKB:P89055 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23890813 interaction assertion for partner(s) UniProtKB:P89055 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:23955153 Pathogen blocks host death receptor signalling by arginine G... | UNDECIDED | Summary: The PMID:23955153 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:23955153 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | UNDECIDED | Summary: The PMID:24658140 interaction assertion for partner(s) UniProtKB:P00533 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:24658140 interaction assertion for partner(s) UniProtKB:P00533 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:24722188 Protein interaction network of alternatively spliced isoform... | UNDECIDED | Summary: The PMID:24722188 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:24722188 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:24722188 Protein interaction network of alternatively spliced isoform... | UNDECIDED | Summary: The PMID:24722188 interaction assertion for partner(s) UniProtKB:X5D778 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:24722188 interaction assertion for partner(s) UniProtKB:X5D778 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25029497 FBXO7 Y52C polymorphism as a potential protective factor in ... | UNDECIDED | Summary: The PMID:25029497 interaction assertion for partner(s) UniProtKB:Q9Y3I1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25029497 interaction assertion for partner(s) UniProtKB:Q9Y3I1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:O75460 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:O75460 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:P09211 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:P09211 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25241761 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25260751 The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in respon... | UNDECIDED | Summary: The PMID:25260751 interaction assertion for partner(s) UniProtKB:Q62925 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25260751 interaction assertion for partner(s) UniProtKB:Q62925 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:B2R8Y4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:B2R8Y4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:G2XKQ0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:G2XKQ0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O60437 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O60437 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P07947 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P07947 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P22415 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P22415 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P24278 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P24278 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P29972 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P29972 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P57682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:P57682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q01844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q01844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q02930-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q02930-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q08117 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q08117 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q0D2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q0D2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q12815 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q12815 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q16649 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q16649 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q16656 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q16656 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q2KHT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q2KHT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q32MK9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q32MK9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q53EP0-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q53EP0-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q53FD0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q53FD0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5GFL6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5GFL6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5T124 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5T8I9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q5T8I9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q63HK5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q63HK5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6BCY4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6BCY4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6NX49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6NX49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6NYC8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6NYC8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6PF18 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6PF18 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6ZS27-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q6ZS27-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86SE9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86SE9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86VK4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86VK4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86X59 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86X59 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86Y33 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86Y33 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86YD7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q86YD7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IV13 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IV13 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IWZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IWZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IYX8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8IYX8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N2X6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N2X6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N5N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N5N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N6N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N6N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N720 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N720 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N9N2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N9N2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N9N5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8N9N5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8NA54 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8NA54 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8NEC5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8NEC5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8TD31-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8TD31-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8WWW0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8WWW0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8WWZ3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q8WWZ3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96CV8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96CV8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96IX9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96IX9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96IZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96IZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96MN9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96MN9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96NC0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q96NC0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BRJ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BRJ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BRP7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BRP7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BSW7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BSW7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BV90 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BV90 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BVG8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BVG8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BXF9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BXF9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BXY8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9BXY8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9GZQ4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9GZQ4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9GZU8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9GZU8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H0W8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H0W8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H788 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H788 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H875 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H875 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9HC52 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9HC52 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NTX7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NTX7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NVL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NVL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NX65 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NX65 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9P2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9P2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9UHB7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9UHB7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9UHB7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9UHB7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y2J4-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y2J4-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y5U2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25416956 interaction assertion for partner(s) UniProtKB:Q9Y5U2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25502805 A massively parallel pipeline to clone DNA variants and exam... | UNDECIDED | Summary: The PMID:25502805 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25502805 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25609706 Aminopeptidase P3, a new member of the TNF-TNFR2 signaling c... | UNDECIDED | Summary: The PMID:25609706 interaction assertion for partner(s) UniProtKB:Q9NQH7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25609706 interaction assertion for partner(s) UniProtKB:Q9NQH7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q5JVL4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q5JVL4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | UNDECIDED | Summary: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:25910212 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z3N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z3N6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z3V1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z3V1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z6P0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:A0A0S2Z6P0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:B4DE54 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:B4DE54 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:O15169 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:O15169 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | UNDECIDED | Summary: The PMID:26871637 interaction assertion for partner(s) UniProtKB:Q8N9N5-7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:26871637 interaction assertion for partner(s) UniProtKB:Q8N9N5-7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:27135603 A TRAF-like motif of the inducible costimulator ICOS control... | UNDECIDED | Summary: The PMID:27135603 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:27135603 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29329668 Helicobacter pylori induces direct activation of the lymphot... | UNDECIDED | Summary: The PMID:29329668 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29329668 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29844572 RANK-c attenuates aggressive properties of ER-negative breas... | UNDECIDED | Summary: The PMID:29844572 interaction assertion for partner(s) UniProtKB:Q9Y6Q6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29844572 interaction assertion for partner(s) UniProtKB:Q9Y6Q6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29844572 RANK-c attenuates aggressive properties of ER-negative breas... | UNDECIDED | Summary: The PMID:29844572 interaction assertion for partner(s) UniProtKB:Q9Y6Q6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29844572 interaction assertion for partner(s) UniProtKB:Q9Y6Q6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29883609 PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylat... | UNDECIDED | Summary: The PMID:29883609 interaction assertion for partner(s) UniProtKB:Q9Y572 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29883609 interaction assertion for partner(s) UniProtKB:Q9Y572 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: The PMID:29892012 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29892012 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: The PMID:29892012 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29892012 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | UNDECIDED | Summary: The PMID:29892012 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:29892012 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30402268 Haploinsufficiency of A20 impairs protein-protein interactom... | UNDECIDED | Summary: The PMID:30402268 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30402268 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q12815 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q12815 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13627 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q13627 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | UNDECIDED | Summary: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:30561431 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:O60941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P46527 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q6NX49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q6NX49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q96JS3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | UNDECIDED | Summary: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31515488 interaction assertion for partner(s) UniProtKB:Q9UKG1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31617661 Global Interactome Mapping of Mitochondrial Intermembrane Sp... | UNDECIDED | Summary: The PMID:31617661 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31617661 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | UNDECIDED | Summary: The PMID:31980649 interaction assertion for partner(s) UniProtKB:P00533 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31980649 interaction assertion for partner(s) UniProtKB:P00533 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | UNDECIDED | Summary: The PMID:31980649 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:31980649 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:A0A0A0MR80 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:A0A0A0MR80 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:A0A384ME25 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:A0A384ME25 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:C9JRZ8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:C9JRZ8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:E9PSE9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:E9PSE9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O00233 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O00233 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O00463 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O00463 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O15273 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O15273 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O15353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O15353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43167 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43167 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43708 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43708 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O43741 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O60437 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O60437 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O60941-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O60941-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75367 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75367 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75604 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75808 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75808 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75928-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O75928-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O76041 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95363 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95363 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95863 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95863 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95872 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95872 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95990-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95990-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95994 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95994 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95995 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95995 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P00540 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P00540 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P07947 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P07947 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P09067 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P09067 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P10599 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P10599 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P12268 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P12268 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P13682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P13682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P15622-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P15622-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P20618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P20618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P21580 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P26196 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P26196 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P28676 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P28676 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P35227 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P35227 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P35711-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P35711-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P41182 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P41182 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P41225 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P41225 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P47897 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P47897 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P48380 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P48751 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P48751 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P49639 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P49639 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P49711 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P49711 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P51800-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P51800-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P53672 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P53672 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P55040 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P55040 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P55081 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P55081 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P56279 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P56279 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P57055 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P57055 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P57682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P57682 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P63165 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P63165 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P78317 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:P78317 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q02930-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q02930-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q05516 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q06547 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q07002 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q07002 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q08426 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q08426 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q08495 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q08495 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q0D2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q0D2K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q12805 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13064 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13064 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13526 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13546 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13671 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13671 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13895 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q13895 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14119 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14119 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14142 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14142 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14511-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14511-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14687 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q14687 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15052 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15052 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15560 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15742 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q15742 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16512 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16512 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16543 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16543 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16656-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q16656-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q17RB8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q17RB8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q17RL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q17RL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q2TAL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q2TAL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q2TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q2TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3B820 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3B820 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3MJ62 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3MJ62 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3SY00 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q3SY00 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q496Y0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q496Y0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q49AN0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q49AN0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4G0R1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4G0R1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4V328 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4V328 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4VC44 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q4VC44 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q53FD0-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q53FD0-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q53TS8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q53TS8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5HYW2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5HYW2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5JVL4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5JVL4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T124-6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T124-6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T5P2-6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T5P2-6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T619 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T619 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T7P8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T7P8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T8A7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5T8A7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5TAP6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5TAP6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5W5X9-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q5W5X9-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q63ZY3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q63ZY3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6B0K9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6B0K9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6BCY4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6BCY4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6GPH6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6GPH6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6NX45 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6NX45 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6PF18 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6PF18 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6X4W1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6X4W1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6ZN55-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6ZN55-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6ZSB9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q6ZSB9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7KZS0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7KZS0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7L5A3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7L5A3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z3I7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z3I7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z434 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z4V0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z4V0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z5V6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q7Z5V6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86TN4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86TN4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86UR1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86UR1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86VK4-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86VK4-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86XT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86XT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86Y33-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86Y33-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86YD7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q86YD7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IVT2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IVT2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IVT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IVT4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IXW0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IXW0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IY51 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IY51 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IYH5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IYH5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IYS8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IYS8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IZU1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8IZU1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N3R9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N3R9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N6R0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N6R0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N8B7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N8B7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N9N2-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N9N2-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N9N5-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8N9N5-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8NHY3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8NHY3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8NI38 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8NI38 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TAU3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TAU3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TBE0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TD31-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8TD31-3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8WTU0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8WTU0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8WYQ4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q8WYQ4-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92529 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92529 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92917 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92997 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q92997 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96BZ8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96BZ8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96CG3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96EK7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96EK7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96HA1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96HA1-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96IZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96IZ5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96JC9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96JC9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96JP2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96JP2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MM6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MM6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MP5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MP5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MY7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96MY7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96NC0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96NC0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96NU1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96NU1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96PC2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96PC2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96S90 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q96S90 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q99618 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q99633 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q99633 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRJ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRJ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRP7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRP7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRR0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRR0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRU9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BRU9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BSW7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BSW7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BT49 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BUI4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BUI4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BVG8-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BVG8-5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BWG6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BWG6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BXF9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BXF9 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BXY8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9BXY8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9C086 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9C086 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H0I2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H0W8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H0W8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H5Z6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H5Z6-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HAK2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HAK2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HBE1-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HBE1-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HC52 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HC52 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HC98-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9HC98-4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NRE2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NRE2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NRN7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NTX7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NTX7-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9NZD8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UBU8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UBU8-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UHP6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UHP6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UIF8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UIF8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UJ78-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UJ78-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UN79 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9UN79 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y247 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y247 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y3D2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y3D2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4B4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4B4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4C2-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4C2-2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y6H1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:Q9Y6H1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: The PMID:32296183 interaction assertion for partner(s) UniProtKB:X5D778 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32296183 interaction assertion for partner(s) UniProtKB:X5D778 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | UNDECIDED | Summary: The PMID:32707033 interaction assertion for partner(s) UniProtKB:O43353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32707033 interaction assertion for partner(s) UniProtKB:O43353 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | UNDECIDED | Summary: The PMID:32707033 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32707033 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | UNDECIDED | Summary: The PMID:32814053 interaction assertion for partner(s) UniProtKB:P42858 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32814053 interaction assertion for partner(s) UniProtKB:P42858 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | UNDECIDED | Summary: The PMID:32814053 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:32814053 interaction assertion for partner(s) UniProtKB:P54253 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:O95999 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P26842 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P26842 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:P36941 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13489 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q13490 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q6FIF0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q92844 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9NVF7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9UHD2 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:33961781 interaction assertion for partner(s) UniProtKB:Q9Y4K3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:35914814 Chr21 protein-protein interactions: enrichment in proteins i... | UNDECIDED | Summary: The PMID:35914814 interaction assertion for partner(s) UniProtKB:Q13627 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:35914814 interaction assertion for partner(s) UniProtKB:Q13627 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:A4D2P6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:A4D2P6 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:O43464 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:O75970 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:O75970 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:P78352 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:P78352 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q02410 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q02410 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q07157 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q07157 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q12959 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q12959 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q14005 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q14005 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q14160 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q14160 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q15700 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q15700 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q5T2W1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q5T2W1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q68DX3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q68DX3 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q86UL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q86UL8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q86UT5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q86UT5 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8N448 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8N448 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8NI35 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8NI35 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q8TBB1 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q92796 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q92796 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q92997 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q92997 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q96QZ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q96QZ7 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q99767 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q99767 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9C0E4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9C0E4 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9H8Y8 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9P202 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9P202 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9Y3R0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36115835 interaction assertion for partner(s) UniProtKB:Q9Y3R0 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:36217029 A proteome-scale map of the SARS-CoV-2-human contactome. | UNDECIDED | Summary: The PMID:36217029 interaction assertion for partner(s) UniProtKB:P0DTD1-PRO_0000449631 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:36217029 interaction assertion for partner(s) UniProtKB:P0DTD1-PRO_0000449631 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P25942 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:40205054 interaction assertion for partner(s) UniProtKB:P54725 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | UNDECIDED | Summary: The PMID:8069916 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:8069916 interaction assertion for partner(s) UniProtKB:P20333 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | UNDECIDED | Summary: The PMID:8069916 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:8069916 interaction assertion for partner(s) UniProtKB:Q13077 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | MODIFY | Summary: The directly characterized TRAF2 interaction recruits a component of receptor signaling machinery. Signaling adaptor activity captures the established role more precisely than generic protein binding. Reason: The directly characterized TRAF2 interaction recruits a component of receptor signaling machinery. Signaling adaptor activity captures the established role more precisely than generic protein binding. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0005515 protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | UNDECIDED | Summary: The PMID:9020361 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:9020361 interaction assertion for partner(s) UniProtKB:Q15628 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | UNDECIDED | Summary: The PMID:9020361 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:9020361 interaction assertion for partner(s) UniProtKB:Q99558 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:9153189 ATAR, a novel tumor necrosis factor receptor family member, ... | UNDECIDED | Summary: The PMID:9153189 interaction assertion for partner(s) UniProtKB:Q92956 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:9153189 interaction assertion for partner(s) UniProtKB:Q92956 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:9418902 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-... | UNDECIDED | Summary: The PMID:9418902 interaction assertion for partner(s) UniProtKB:P20334 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:9418902 interaction assertion for partner(s) UniProtKB:P20334 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005515 protein binding | IPI PMID:9692890 The TNF receptor family member CD27 signals to Jun N-termina... | UNDECIDED | Summary: The PMID:9692890 interaction assertion for partner(s) UniProtKB:P26842 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. Reason: The PMID:9692890 interaction assertion for partner(s) UniProtKB:P26842 has not been traced to its bait/prey or complex experiment. Generic protein binding does not identify a molecular role, and source-specific interaction evidence is needed before selecting a more informative term. The annotation is not rejected because of a study title or an incomplete abstract. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8862184 | UNDECIDED | Summary: The specific nucleoplasm assertion from Reactome:R-HSA-8862184 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific nucleoplasm assertion from Reactome:R-HSA-8862184 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005737 cytoplasm | IDA PMID:15383523 TRAF3 forms heterotrimers with TRAF2 and modulates its abili... | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005737 cytoplasm | IDA PMID:19150425 PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitm... | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | IC PMID:40097387 Ubiquitination of gasdermin D N-terminal domain directs its ... | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139952 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-140978 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-141159 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3371360 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3465429 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3465448 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357757 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357776 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357780 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357828 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357845 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357860 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357904 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357928 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5634221 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668414 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668417 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668454 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668481 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668534 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668543 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5675456 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676593 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676595 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676596 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676597 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676598 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5693055 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5693108 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5696627 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-75240 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-83582 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-83656 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8869456 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-918230 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933525 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933527 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933530 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933537 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933538 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9693929 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9697747 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9697750 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705145 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705323 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9750946 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9793679 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9793680 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796342 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796346 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796379 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9815501 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817362 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817397 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817400 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817411 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9818789 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9818975 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9819106 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9824874 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005886 plasma membrane | NAS PMID:21081755 Solution of the structure of the TNF-TNFR2 complex. | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005886 plasma membrane | NAS PMID:33495445 A conformation-selective monoclonal antibody against a small... | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005938 cell cortex | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific cell cortex assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific cell cortex assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0006954 inflammatory response | NAS PMID:20194223 Transmembrane TNF-alpha: structure, function and interaction... | KEEP AS NON CORE | Summary: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Reason: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0006954 inflammatory response | NAS PMID:33800290 The Role of Tumor Necrosis Factor Alpha (TNF-Ξ±) in Autoimmun... | KEEP AS NON CORE | Summary: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Reason: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0007165 signal transduction | TAS PMID:8702708 Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0007249 canonical NF-kappaB signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0008270 zinc ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: The experimentally resolved RING/zinc-finger architecture supports structural metal coordination. This structural property is compatible with adaptor function and does not establish ubiquitin-ligase activity. Reason: The experimentally resolved RING/zinc-finger architecture supports structural metal coordination. This structural property is compatible with adaptor function and does not establish ubiquitin-ligase activity. Supporting Evidence: PMID:19810754 Here we report the crystal structure of the RING and the first zinc finger domains of TRAF2. |
| GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors | NAS PMID:36380021 Death by TNF: a road to inflammation. | UNDECIDED | Summary: The specific extrinsic apoptotic signaling pathway via death domain receptors assertion from PMID:36380021 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific extrinsic apoptotic signaling pathway via death domain receptors assertion from PMID:36380021 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage | NAS PMID:21458669 NEMO and RIP1 control cell fate in response to extensive DNA... | UNDECIDED | Summary: The specific intrinsic apoptotic signaling pathway in response to DNA damage assertion from PMID:21458669 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific intrinsic apoptotic signaling pathway in response to DNA damage assertion from PMID:21458669 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0009898 cytoplasmic side of plasma membrane | IC PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0009898 cytoplasmic side of plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0009898 cytoplasmic side of plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Reason: TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Reason: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0012501 programmed cell death | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Reason: Cell-death regulation and altered inflammatory gene expression are contextual outputs of TRAF2-dependent NF-kappaB/MAPK signaling. These broad outcomes do not replace the molecular adaptor mechanism. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0012506 vesicle membrane | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific vesicle membrane assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific vesicle membrane assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0016567 protein ubiquitination | IEA GO_REF:0000041 | ACCEPT | Summary: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Reason: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0019899 enzyme binding | IEA GO_REF:0000117 | ACCEPT | Summary: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Reason: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0019899 enzyme binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | ACCEPT | Summary: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Reason: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: IRE1 and ASK1 recruitment connects TRAF2 to kinase-containing ER-stress signaling assemblies. The original IRE1 study reports direct interaction of the IRE1 cytoplasmic region with TRAF2. Reason: IRE1 and ASK1 recruitment connects TRAF2 to kinase-containing ER-stress signaling assemblies. The original IRE1 study reports direct interaction of the IRE1 cytoplasmic region with TRAF2. Supporting Evidence: PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:0019901 protein kinase binding | IPI PMID:10650002 Coupling of stress in the ER to activation of JNK protein ki... | ACCEPT | Summary: IRE1 and ASK1 recruitment connects TRAF2 to kinase-containing ER-stress signaling assemblies. The original IRE1 study reports direct interaction of the IRE1 cytoplasmic region with TRAF2. Reason: IRE1 and ASK1 recruitment connects TRAF2 to kinase-containing ER-stress signaling assemblies. The original IRE1 study reports direct interaction of the IRE1 cytoplasmic region with TRAF2. Supporting Evidence: PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:0019903 protein phosphatase binding | IPI PMID:15696169 Selective regulation of tumor necrosis factor-induced Erk si... | ACCEPT | Summary: The TCPTP study explicitly reports interaction with TRAF2 and links the phosphatase/Src axis to selective TNF-induced ERK signaling. Protein phosphatase binding is mechanistically informative here. Reason: The TCPTP study explicitly reports interaction with TRAF2 and links the phosphatase/Src axis to selective TNF-induced ERK signaling. Protein phosphatase binding is mechanistically informative here. Supporting Evidence: PMID:15696169 TCPTP interacted with the adaptor protein TRAF2, and dephosphorylated and inactivated Src tyrosine kinases to suppress downstream signaling through extracellular signal-regulated kinases and production of interleukin 6. |
| GO:0023035 CD40 signaling pathway | IDA PMID:15708970 TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an ... | ACCEPT | Summary: CD40 mutant experiments distinguish TRAF2/5-dependent canonical and noncanonical NF-kappaB signaling from TRAF6-dependent canonical signaling. TRAF2 participates in this receptor-dependent regulatory circuitry; this does not assert unconditional positive regulation of NIK in unstimulated cells. Reason: CD40 mutant experiments distinguish TRAF2/5-dependent canonical and noncanonical NF-kappaB signaling from TRAF6-dependent canonical signaling. TRAF2 participates in this receptor-dependent regulatory circuitry; this does not assert unconditional positive regulation of NIK in unstimulated cells. Supporting Evidence: PMID:15708970 Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0030674 protein-macromolecule adaptor activity | IEA GO_REF:0000117 | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0030674 protein-macromolecule adaptor activity | IPI PMID:20447407 Asymmetric recruitment of cIAPs by TRAF2. | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0031435 mitogen-activated protein kinase kinase kinase binding | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific mitogen-activated protein kinase kinase kinase binding assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific mitogen-activated protein kinase kinase kinase binding assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0031625 ubiquitin protein ligase binding | IDA PMID:23951545 MAVS recruits multiple ubiquitin E3 ligases to activate anti... | ACCEPT | Summary: The reconstituted cIAP1βTRAF2 interaction establishes ubiquitin-ligase binding as a functional recruitment mechanism. This supports the molecular claim without treating every interaction-paper annotation as independently reverified. Reason: The reconstituted cIAP1βTRAF2 interaction establishes ubiquitin-ligase binding as a functional recruitment mechanism. This supports the molecular claim without treating every interaction-paper annotation as independently reverified. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: The reconstituted cIAP1βTRAF2 interaction establishes ubiquitin-ligase binding as a functional recruitment mechanism. This supports the molecular claim without treating every interaction-paper annotation as independently reverified. Reason: The reconstituted cIAP1βTRAF2 interaction establishes ubiquitin-ligase binding as a functional recruitment mechanism. This supports the molecular claim without treating every interaction-paper annotation as independently reverified. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0031996 thioesterase binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | UNDECIDED | Summary: The specific thioesterase binding assertion from PMID:11279055 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific thioesterase binding assertion from PMID:11279055 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0032743 positive regulation of interleukin-2 production | IMP PMID:15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activ... | ACCEPT | Summary: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Reason: RNAi against TRAF2 suppresses TCR-dependent IKK activation and interleukin-2 production. The abstract explicitly includes TRAF2 despite emphasizing TRAF6 in the title; the cytokine-production claim is experimentally supported. Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0032813 tumor necrosis factor receptor superfamily binding | IEA GO_REF:0000117 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | ACCEPT | Summary: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Reason: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IMP PMID:12296995 TAK1-dependent activation of AP-1 and c-Jun N-terminal kinas... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | NAS PMID:20194223 Transmembrane TNF-alpha: structure, function and interaction... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | NAS PMID:33495441 Structural insights into the disruption of TNF-TNFR1 signall... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0034351 negative regulation of glial cell apoptotic process | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific negative regulation of glial cell apoptotic process assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific negative regulation of glial cell apoptotic process assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0034976 response to endoplasmic reticulum stress | NAS PMID:10650002 Coupling of stress in the ER to activation of JNK protein ki... | ACCEPT | Summary: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Reason: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0035591 signaling adaptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0035591 signaling adaptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Reason: TRAF2 assembles receptor-associated signaling machinery by recruiting cIAP ubiquitin ligases and other partners. The reconstituted TRAF2βcIAP1 complex directly establishes an adaptor role independently of disputed intrinsic ubiquitin-transfer chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0035631 CD40 receptor complex | IEA GO_REF:0000107 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0035631 CD40 receptor complex | ISS GO_REF:0000024 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0038061 non-canonical NF-kappaB signal transduction | IDA PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | ACCEPT | Summary: CD40 mutant experiments distinguish TRAF2/5-dependent canonical and noncanonical NF-kappaB signaling from TRAF6-dependent canonical signaling. TRAF2 participates in this receptor-dependent regulatory circuitry; this does not assert unconditional positive regulation of NIK in unstimulated cells. Reason: CD40 mutant experiments distinguish TRAF2/5-dependent canonical and noncanonical NF-kappaB signaling from TRAF6-dependent canonical signaling. TRAF2 participates in this receptor-dependent regulatory circuitry; this does not assert unconditional positive regulation of NIK in unstimulated cells. Supporting Evidence: PMID:15708970 Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0042110 T cell activation | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | KEEP AS NON CORE | Summary: CD27-dependent recruitment of TRAF2 and SHP-1 regulates naive T-cell fate and memory differentiation. This is a specific receptor/cell-state deployment of the broader adaptor role. Reason: CD27-dependent recruitment of TRAF2 and SHP-1 regulates naive T-cell fate and memory differentiation. This is a specific receptor/cell-state deployment of the broader adaptor role. Supporting Evidence: PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0042802 identical protein binding | IEA GO_REF:0000117 | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | ACCEPT | Summary: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Reason: Biophysical reconstitution establishes a trimeric TRAF2 coiled-coil scaffold. Self-association is a functional assembly property, although individual high-throughput interaction records are not independent mechanistic demonstrations. Supporting Evidence: PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042981 regulation of apoptotic process | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0042981 regulation of apoptotic process | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043120 tumor necrosis factor binding | IPI PMID:23429285 EVER2 protein binds TRADD to promote TNF-Ξ±-induced apoptosis... | UNDECIDED | Summary: QuickGO defines this as binding the TNF cytokine itself, not its receptor. The full EVER2/TRADD paper measures recruitment of TRAF2 into TNFR1 complex I; ligand-mediated affinity isolation can recover an indirectly associated intracellular adaptor. Direct cytokine contact is not established by those complexes. The precise curated interaction evidence requires resolution before choosing a replacement. Reason: QuickGO defines this as binding the TNF cytokine itself, not its receptor. The full EVER2/TRADD paper measures recruitment of TRAF2 into TNFR1 complex I; ligand-mediated affinity isolation can recover an indirectly associated intracellular adaptor. Direct cytokine contact is not established by those complexes. The precise curated interaction evidence requires resolution before choosing a replacement. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:26458771 Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis thro... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:29581234 TRAF-interacting protein with forkhead-associated domain (TI... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IMP PMID:12296995 TAK1-dependent activation of AP-1 and c-Jun N-terminal kinas... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IMP PMID:15121867 TRAF family proteins link PKR with NF-kappa B activation. | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043235 signaling receptor complex | IEA GO_REF:0000117 | ACCEPT | Summary: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Reason: Direct binding of recombinant human TRAF2 to the CD40 cytoplasmic tail and recruitment to TNF receptor signaling assemblies establish receptor binding and receptor-complex membership. This is intracellular receptor engagement, not binding to extracellular TNF cytokine. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043254 regulation of protein-containing complex assembly | IMP PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | ACCEPT | Summary: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Reason: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0043408 regulation of MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0043507 positive regulation of JUN kinase activity | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000120 | UNDECIDED | Summary: The specific protein-containing complex binding assertion from GO_REF:0000120 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific protein-containing complex binding assertion from GO_REF:0000120 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0045121 membrane raft | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific membrane raft assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific membrane raft assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0046328 regulation of JNK cascade | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0046625 sphingolipid binding | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | KEEP AS NON CORE | Summary: Direct S1P affinity binding by recombinant TRAF2 supports this lipid-binding annotation. Its proposed catalytic cofactor role is mechanistically contested and lipid binding alone is not the central receptor-adaptor function. Reason: Direct S1P affinity binding by recombinant TRAF2 supports this lipid-binding annotation. Its proposed catalytic cofactor role is mechanistically contested and lipid binding alone is not the central receptor-adaptor function. Supporting Evidence: PMID:20577214 Moreover, recombinant TRAF2 purified from Sf9 insect cells also bound to S1P beads, whereas RIP1 and ΞRING-TRAF2 did not (Supplementary Fig. 7d,e,f). |
| GO:0046872 metal ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: The experimentally resolved RING/zinc-finger architecture supports structural metal coordination. This structural property is compatible with adaptor function and does not establish ubiquitin-ligase activity. Reason: The experimentally resolved RING/zinc-finger architecture supports structural metal coordination. This structural property is compatible with adaptor function and does not establish ubiquitin-ligase activity. Supporting Evidence: PMID:19810754 Here we report the crystal structure of the RING and the first zinc finger domains of TRAF2. |
| GO:0048255 mRNA stabilization | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific mRNA stabilization assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific mRNA stabilization assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0051865 protein autoubiquitination | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | UNDECIDED | Summary: S1P-dependent recombinant TRAF2 autoubiquitination is reported, but TRAF2 is also a directly demonstrated cIAP substrate. A ubiquitinated TRAF2 band alone does not establish self-catalysis; the conflicting E2-interface evidence requires a cofactor- and preparation-specific interpretation. Reason: S1P-dependent recombinant TRAF2 autoubiquitination is reported, but TRAF2 is also a directly demonstrated cIAP substrate. A ubiquitinated TRAF2 band alone does not establish self-catalysis; the conflicting E2-interface evidence requires a cofactor- and preparation-specific interpretation. Supporting Evidence: PMID:20577214 S1P also stimulated in vitro autoubiquitination of recombinant TRAF2 (Supplementary Fig. 8d). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:11907583 Although c-IAP1 bound TRAF2 and TRAF1 in vitro, it ubiquitinated only TRAF2. |
| GO:0051865 protein autoubiquitination | IEA GO_REF:0000002 | UNDECIDED | Summary: S1P-dependent recombinant TRAF2 autoubiquitination is reported, but TRAF2 is also a directly demonstrated cIAP substrate. A ubiquitinated TRAF2 band alone does not establish self-catalysis; the conflicting E2-interface evidence requires a cofactor- and preparation-specific interpretation. Reason: S1P-dependent recombinant TRAF2 autoubiquitination is reported, but TRAF2 is also a directly demonstrated cIAP substrate. A ubiquitinated TRAF2 band alone does not establish self-catalysis; the conflicting E2-interface evidence requires a cofactor- and preparation-specific interpretation. Supporting Evidence: PMID:20577214 S1P also stimulated in vitro autoubiquitination of recombinant TRAF2 (Supplementary Fig. 8d). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:11907583 Although c-IAP1 bound TRAF2 and TRAF1 in vitro, it ubiquitinated only TRAF2. |
| GO:0061630 ubiquitin protein ligase activity | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0061630 ubiquitin protein ligase activity | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0061630 ubiquitin protein ligase activity | IEA GO_REF:0000120 | UNDECIDED | Summary: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Reason: Intrinsic TRAF2 ubiquitin-transfer activity is contested at the mechanistic level: the RING/E2 structural and biochemical study finds an unfavorable E2 interface, whereas a later purified-protein study reports S1P-dependent RIP1 ubiquitination and excludes detectable cIAP1/2 contamination. The positive assay cannot be discarded from the negative study alone, nor can cIAP recruitment establish TRAF2 catalysis. A universal autonomous E3 assignment remains unresolved. Supporting Evidence: PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0065003 protein-containing complex assembly | IEA GO_REF:0000107 | ACCEPT | Summary: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Reason: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0065003 protein-containing complex assembly | ISS GO_REF:0000024 | ACCEPT | Summary: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Reason: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0065003 protein-containing complex assembly | TAS PMID:8702708 Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB... | ACCEPT | Summary: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Reason: Reconstitution of the TRAF2βcIAP1 complex and receptor-tail recruitment directly demonstrate assembly of signaling machinery. Broad complex terms are biologically correct but less descriptive than the named receptor/ligase assemblies. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | TAS PMID:14685163 Roles of CHOP/GADD153 in endoplasmic reticulum stress. | KEEP AS NON CORE | Summary: IRE1βTRAF2βASK1 complex formation connects severe ER stress to pro-apoptotic ASK1/JNK signaling. This stimulus-dependent outcome is supported by primary human-cell evidence in addition to the original review citations. Reason: IRE1βTRAF2βASK1 complex formation connects severe ER stress to pro-apoptotic ASK1/JNK signaling. This stimulus-dependent outcome is supported by primary human-cell evidence in addition to the original review citations. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | TAS PMID:22013210 The unfolded protein response: integrating stress signals th... | KEEP AS NON CORE | Summary: IRE1βTRAF2βASK1 complex formation connects severe ER stress to pro-apoptotic ASK1/JNK signaling. This stimulus-dependent outcome is supported by primary human-cell evidence in addition to the original review citations. Reason: IRE1βTRAF2βASK1 complex formation connects severe ER stress to pro-apoptotic ASK1/JNK signaling. This stimulus-dependent outcome is supported by primary human-cell evidence in addition to the original review citations. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:15258597 De-ubiquitination and ubiquitin ligase domains of A20 downre... | ACCEPT | Summary: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Reason: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | ACCEPT | Summary: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Reason: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | ACCEPT | Summary: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Reason: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0070534 protein K63-linked ubiquitination | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Reason: TRAF2 participates in ubiquitination signaling through recruitment of cIAPs and reported TRAF2-dependent K63-chain formation. Biological-process participation does not identify which complex subunit provides intrinsic E3 chemistry. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0097057 TRAF2-GSTP1 complex | IDA PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | ACCEPT | Summary: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Reason: The GSTP1 study directly establishes a TRAF2-containing complex and links GSTP1 binding to suppression of TRAF2βASK1 signaling. This is a regulatory protein interaction, not evidence that TRAF2 is a GST enzyme. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0097400 interleukin-17-mediated signaling pathway | IEA GO_REF:0000107 | UNDECIDED | Summary: The specific interleukin-17-mediated signaling pathway assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific interleukin-17-mediated signaling pathway assertion from GO_REF:0000107 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
| GO:0140639 positive regulation of pyroptotic inflammatory response | IDA PMID:40097387 Ubiquitination of gasdermin D N-terminal domain directs its ... | KEEP AS NON CORE | Summary: The full text directly tests TRAF2, reports enhanced GD-NT ubiquitination and restored cytolytic activity of tagged GD-NT upon TRAF2 coexpression. This supports a positive process effect in the reported overexpression system; it neither establishes direct GSDMD binding nor identifies TRAF2 as the autonomous ligase. Reason: The full text directly tests TRAF2, reports enhanced GD-NT ubiquitination and restored cytolytic activity of tagged GD-NT upon TRAF2 coexpression. This supports a positive process effect in the reported overexpression system; it neither establishes direct GSDMD binding nor identifies TRAF2 as the autonomous ligase. Supporting Evidence: PMID:40097387 Moreover, we found that 3βΓβFlag-GD-NT, which loses its pore-forming activity due to the addition of triple Flag-tag on its N-terminal [3], regained the ability to mediate pyroptosis with the assistance of TRAF1 and TRAF2 (Fig. 2IβK). |
| GO:0160162 CD27 signaling pathway | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | KEEP AS NON CORE | Summary: CD27-dependent recruitment of TRAF2 and SHP-1 regulates naive T-cell fate and memory differentiation. This is a specific receptor/cell-state deployment of the broader adaptor role. Reason: CD27-dependent recruitment of TRAF2 and SHP-1 regulates naive T-cell fate and memory differentiation. This is a specific receptor/cell-state deployment of the broader adaptor role. Supporting Evidence: PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Reason: TRAF2 coordinates TNF-family receptor signaling, activating NF-kappaB/JNK and controlling survival versus apoptosis through receptor-associated assemblies. This process participation is supported even when the ubiquitin chemistry is performed by recruited cIAPs. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:1905669 TORC1 complex assembly | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | KEEP AS NON CORE | Summary: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Reason: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905669 TORC1 complex assembly | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Reason: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905670 TORC2 complex disassembly | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | KEEP AS NON CORE | Summary: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Reason: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905670 TORC2 complex disassembly | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Reason: The full GbetaL/OTUD7B study reports TRAF2-dependent K63 ubiquitination of GbetaL, impaired SIN1 association, and a shift from mTORC2 toward mTORC1. These complex-assembly outcomes are supported in the studied cell systems independently of whether the isolated TRAF2 polypeptide alone supplies ubiquitin-transfer chemistry. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IBA GO_REF:0000033 | ACCEPT | Summary: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Reason: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IDA PMID:23000344 Ursolic acid induces ER stress response to activate ASK1-JNK... | ACCEPT | Summary: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Reason: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IEA GO_REF:0000120 | ACCEPT | Summary: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Reason: Human bladder-cell experiments demonstrate formation of an IRE1βTRAF2βASK1 assembly during ER stress, with JNK signaling. This complex role does not imply that TRAF2 is an ER membrane-spanning protein. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:2001238 positive regulation of extrinsic apoptotic signaling pathway | IMP PMID:21525013 TWEAK induces apoptosis through a death-signaling complex co... | UNDECIDED | Summary: The specific positive regulation of extrinsic apoptotic signaling pathway assertion from PMID:21525013 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. Reason: The specific positive regulation of extrinsic apoptotic signaling pathway assertion from PMID:21525013 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role. |
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