TRAF2 is a cytoplasmic signaling adaptor of the TNF receptor-associated factor family. Through its C-terminal TRAF/MATH domain it binds the cytoplasmic tails of TNF receptor superfamily members (directly, as for TNFR2, CD40, CD27 and FN14, or via TRADD for TNFR1), and through its trimeric coiled coil it recruits the cIAP1/cIAP2 ubiquitin ligases together with MAP3Ks such as ASK1 and MEKK1. These assemblies drive K63-linked ubiquitination of RIPK1 and other targets, activation of canonical NF-kappaB and JNK, and suppression of TNF-induced cell death; with TRAF3 and cIAPs, TRAF2 also limits non-canonical NF-kappaB by controlling NIK. TRAF2 couples IRE1 to ASK1/JNK during ER stress. Its N-terminal RING domain has weak ubiquitin ligase activity in reconstituted reactions with sphingosine-1-phosphate, but in several cellular settings the RING is dispensable, and much of its ubiquitin signaling is carried out by recruited E3 ligases.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000151 ubiquitin ligase complex | IPI PMID:17314283 Parkin mediates neuroprotection through activation of Ikappa... | ACCEPT | Summary: TRAF2 forms stable complexes with the cIAP1/cIAP2 E3 ligases (one cIAP per TRAF2 trimer) and is also reported in complexes with other E3s such as Parkin; it is therefore part of ubiquitin ligase complexes. Reason: Membership of TRAF2-cIAP E3 assemblies is directly shown by reconstitution of the cIAP1 BIR1-TRAF2 coiled-coil complex. This holds whether or not TRAF2 itself contributes catalysis. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0000151 ubiquitin ligase complex | IPI PMID:29581234 TRAF-interacting protein with forkhead-associated domain (TI... | ACCEPT | Summary: TRAF2 forms stable complexes with the cIAP1/cIAP2 E3 ligases (one cIAP per TRAF2 trimer) and is also reported in complexes with other E3s such as Parkin; it is therefore part of ubiquitin ligase complexes. Reason: Membership of TRAF2-cIAP E3 assemblies is directly shown by reconstitution of the cIAP1 BIR1-TRAF2 coiled-coil complex. This holds whether or not TRAF2 itself contributes catalysis. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0002224 toll-like receptor signaling pathway | IDA PMID:26458771 Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis thro... | UNDECIDED | Summary: The cited study (TIFAB) uses TRAF2 only as a comparator: TIFAB does not repress TRAF2-driven NF-kappaB, which the authors attribute to TNFR2/TRAF2 rather than TLR/TRAF6 signaling. Reason: The cited text does not show TRAF2 acting in a TLR pathway; if anything it contrasts TRAF2 with the TLR/TRAF6 branch. Other work (TICAM1 ubiquitination, MAVS-dependent signaling) suggests TRAF2 can act in innate-immune pathways, so the claim is not rejected, but this reference does not support it. Supporting Evidence: PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0002700 regulation of production of molecular mediator of immune response | IEA GO_REF:0000117 | MODIFY | Summary: ARBA-derived broad term. TRAF2 knockdown reduces TCR-induced IKK activation and IL-2 production. Reason: The general term is true but is better expressed by the more specific descendant positive regulation of T cell cytokine production (GO:0002726), which the gene already carries by IMP. This is a downstream cellular output of TRAF2-dependent NF-kappaB signaling and non-core. Proposed replacements: positive regulation of T cell cytokine production Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0002726 positive regulation of T cell cytokine production | IMP PMID:15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activ... | KEEP AS NON CORE | Summary: RNAi against TRAF2 in T cells reduces TCR-dependent IKK activation and IL-2 production. Reason: Experimentally supported in human T cells, but cytokine output is a consequence of TRAF2's adaptor role in NF-kappaB activation, not its core activity. Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0002947 tumor necrosis factor receptor superfamily complex | IDA PMID:23429285 EVER2 protein binds TRADD to promote TNF-Ξ±-induced apoptosis... | ACCEPT | Summary: TRAF2 is a constitutive component of ligand-engaged TNF receptor superfamily signaling complexes (e.g. TNFR1 complex I via TRADD; CD40, TNFR2 and FN14 complexes by direct receptor binding). Reason: Receptor-complex membership is the central location of TRAF2 function and is directly supported by the recruitment of TRAF2 into TNFR1 complex I and into the FN14-TRAF2-cIAP1 complex. Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 PMID:21525013 TWEAK assembled a proximal signaling complex containing its cognate receptor FN14, the adaptor TRAF2, and cellular inhibitor of apoptosis protein 1 (cIAP1). |
| GO:0002947 tumor necrosis factor receptor superfamily complex | NAS PMID:15861135 TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ub... | ACCEPT | Summary: TRAF2 is a constitutive component of ligand-engaged TNF receptor superfamily signaling complexes (e.g. TNFR1 complex I via TRADD; CD40, TNFR2 and FN14 complexes by direct receptor binding). Reason: Receptor-complex membership is the central location of TRAF2 function and is directly supported by the recruitment of TRAF2 into TNFR1 complex I and into the FN14-TRAF2-cIAP1 complex. Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 PMID:21525013 TWEAK assembled a proximal signaling complex containing its cognate receptor FN14, the adaptor TRAF2, and cellular inhibitor of apoptosis protein 1 (cIAP1). |
| GO:0002947 tumor necrosis factor receptor superfamily complex | NAS PMID:36179048 Novel biochemical, structural, and systems insights into inf... | ACCEPT | Summary: TRAF2 is a constitutive component of ligand-engaged TNF receptor superfamily signaling complexes (e.g. TNFR1 complex I via TRADD; CD40, TNFR2 and FN14 complexes by direct receptor binding). Reason: Receptor-complex membership is the central location of TRAF2 function and is directly supported by the recruitment of TRAF2 into TNFR1 complex I and into the FN14-TRAF2-cIAP1 complex. Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 PMID:21525013 TWEAK assembled a proximal signaling complex containing its cognate receptor FN14, the adaptor TRAF2, and cellular inhibitor of apoptosis protein 1 (cIAP1). |
| GO:0004842 ubiquitin-protein transferase activity | EXP PMID:26620909 Reversible ubiquitination shapes NLRC5 function and modulate... | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0004842 ubiquitin-protein transferase activity | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0004842 ubiquitin-protein transferase activity | IDA PMID:15258597 De-ubiquitination and ubiquitin ligase domains of A20 downre... | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0004842 ubiquitin-protein transferase activity | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0004842 ubiquitin-protein transferase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0005164 tumor necrosis factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005164 tumor necrosis factor receptor binding | IPI PMID:11728344 A novel TNF receptor family member binds TWEAK and is implic... | ACCEPT | Summary: TRAF2 binds the cytoplasmic tails of many TNF receptor superfamily members (TNFR2, CD40, CD27, LTBR, HVEM, FN14 and others) through its C-terminal TRAF/MATH domain. PAINT places this term at node PTN000805720 covering TRAF1/TRAF2. Reason: Direct binding of recombinant TRAF2 to the CD40 cytoplasmic domain, together with the PAINT node and the many receptor IPIs, establishes TNF receptor binding as a core TRAF2 activity. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005174 CD40 receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Projected from mouse Traf2 (same PANTHER subfamily PTHR10131:SF21). Human TRAF2 binds the CD40 cytoplasmic domain directly. Reason: Direct human evidence agrees with the orthology-based transfer. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005174 CD40 receptor binding | ISS GO_REF:0000024 | ACCEPT | Summary: Projected from mouse Traf2 (same PANTHER subfamily PTHR10131:SF21). Human TRAF2 binds the CD40 cytoplasmic domain directly. Reason: Direct human evidence agrees with the orthology-based transfer. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005515 protein binding | IPI PMID:10075662 Activation of NF-kappaB by RANK requires tumor necrosis fact... | MODIFY | Summary: PMID:10075662 reports a TRAF2 interaction with TNFRSF11A/RANK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF11A/RANK) is the informative part of this IPI. Binding of TRAF2 to TNFRSF11A/RANK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:10514511 TRAF family proteins interact with the common neurotrophin r... | MODIFY | Summary: PMID:10514511 reports a TRAF2 interaction with rat NGFR/TNFRSF16. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (rat NGFR/TNFRSF16) is the informative part of this IPI. Binding of TRAF2 to rat NGFR/TNFRSF16 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:10518213 The structural basis for the recognition of diverse receptor... | MODIFY | Summary: PMID:10518213 reports a TRAF2 interaction with mouse TNFRSF9/4-1BB. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (mouse TNFRSF9/4-1BB) is the informative part of this IPI. Binding of TRAF2 to mouse TNFRSF9/4-1BB is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:10518213 The structural basis for the recognition of diverse receptor... | MODIFY | Summary: PMID:10518213 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:10521462 TNIK, a novel member of the germinal center kinase family th... | MODIFY | Summary: PMID:10521462 reports a TRAF2 interaction with TNIK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNIK) is the informative part of this IPI. Binding of TRAF2 to TNIK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:10892748 A novel mechanism of TRAF signaling revealed by structural a... | MODIFY | Summary: PMID:10892748 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | REMOVE | Summary: Generic protein-binding IPI from PMID:11278723 (partner UniProtKB:O08736). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | MODIFY | Summary: PMID:11278723 reports a TRAF2 interaction with ERN1/IRE1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (ERN1/IRE1) is the informative part of this IPI. Binding of TRAF2 to ERN1/IRE1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | MODIFY | Summary: PMID:11278723 reports a TRAF2 interaction with TAOK3. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TAOK3) is the informative part of this IPI. Binding of TRAF2 to TAOK3 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:11466612 Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulate... | REMOVE | Summary: Generic protein-binding IPI from PMID:11466612 (partner UniProtKB:O95999). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11777919 Sphingosine kinase interacts with TRAF2 and dissects tumor n... | REMOVE | Summary: Generic protein-binding IPI from PMID:11777919 (partner UniProtKB:Q9NRA0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11798190 T2BP, a novel TRAF2 binding protein, can activate NF-kappaB ... | REMOVE | Summary: Generic protein-binding IPI from PMID:11798190 (partner UniProtKB:Q96CG3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | MODIFY | Summary: PMID:11907583 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | MODIFY | Summary: PMID:11907583 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | MODIFY | Summary: PMID:14743216 reports a TRAF2 interaction with TNFRSF1B/TNFR2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF1B/TNFR2) is the informative part of this IPI. Binding of TRAF2 to TNFRSF1B/TNFR2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein-binding IPI from PMID:14743216 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | MODIFY | Summary: PMID:14743216 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein-binding IPI from PMID:14743216 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | REMOVE | Summary: Generic protein-binding IPI from PMID:14743216 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:15121867 TRAF family proteins link PKR with NF-kappa B activation. | MODIFY | Summary: PMID:15121867 reports a TRAF2 interaction with EIF2AK2/PKR. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (EIF2AK2/PKR) is the informative part of this IPI. Binding of TRAF2 to EIF2AK2/PKR is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:O60941). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:O75604). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:P24278). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:P46527). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:P48380). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:P54725). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q05516). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | MODIFY | Summary: PMID:16189514 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q13526). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q15560). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q5T124). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q6FIF0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q8N2X6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q8N9N5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q8TBB1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q8TBE0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q96CG3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q96EK7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q96IX9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q99618). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9BT49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9H0I2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9H8Y8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9NRN7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9NVF7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9NZD8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9UKG1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein-binding IPI from PMID:16189514 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16282325 Distinct BIR domains of cIAP1 mediate binding to and ubiquit... | MODIFY | Summary: PMID:16282325 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:16282325 Distinct BIR domains of cIAP1 mediate binding to and ubiquit... | MODIFY | Summary: PMID:16282325 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:16311516 The KSHV oncoprotein vFLIP contains a TRAF-interacting motif... | REMOVE | Summary: Generic protein-binding IPI from PMID:16311516 (partner UniProtKB:P88961). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | REMOVE | Summary: Generic protein-binding IPI from PMID:16636664 (partner UniProtKB:P09211). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | MODIFY | Summary: PMID:16636664 reports a TRAF2 interaction with MAP3K5/ASK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K5/ASK1) is the informative part of this IPI. Binding of TRAF2 to MAP3K5/ASK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:16713569 A protein-protein interaction network for human inherited at... | REMOVE | Summary: Generic protein-binding IPI from PMID:16713569 (partner UniProtKB:P54253). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:17389591 RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site ... | REMOVE | Summary: Generic protein-binding IPI from PMID:17389591 (partner UniProtKB:Q5VWQ8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:19332782 Unconventional ligand activation of herpesvirus entry mediat... | MODIFY | Summary: PMID:19332782 reports a TRAF2 interaction with TNFRSF14/HVEM. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF14/HVEM) is the informative part of this IPI. Binding of TRAF2 to TNFRSF14/HVEM is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:19805025 CIB1 functions as a Ca(2+)-sensitive modulator of stress-ind... | MODIFY | Summary: PMID:19805025 reports a TRAF2 interaction with MAP3K5/ASK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K5/ASK1) is the informative part of this IPI. Binding of TRAF2 to MAP3K5/ASK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:20447407 Asymmetric recruitment of cIAPs by TRAF2. | MODIFY | Summary: PMID:20447407 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | REMOVE | Summary: Generic protein-binding IPI from PMID:20562859 (partner UniProtKB:O43464). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | MODIFY | Summary: PMID:20562859 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | MODIFY | Summary: PMID:20562859 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | REMOVE | Summary: Generic protein-binding IPI from PMID:20562859 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | REMOVE | Summary: Generic protein-binding IPI from PMID:20562859 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:20676093 The transmembrane activator TACI triggers immunoglobulin cla... | MODIFY | Summary: PMID:20676093 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:20732415 The MYND domain-containing protein BRAM1 inhibits lymphotoxi... | MODIFY | Summary: PMID:20732415 reports a TRAF2 interaction with LTBR/TNFRSF3. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (LTBR/TNFRSF3) is the informative part of this IPI. Binding of TRAF2 to LTBR/TNFRSF3 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:O43741). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:Q06547). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:Q5T124). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:Q8N448). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:Q9P2K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein-binding IPI from PMID:21516116 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21525013 TWEAK induces apoptosis through a death-signaling complex co... | MODIFY | Summary: PMID:21525013 reports a TRAF2 interaction with TNFRSF12A/FN14. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF12A/FN14) is the informative part of this IPI. Binding of TRAF2 to TNFRSF12A/FN14 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:21653699 Cellular inhibitor of apoptosis protein-1 (cIAP1) can regula... | MODIFY | Summary: PMID:21653699 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:21782231 MAVS forms functional prion-like aggregates to activate and ... | REMOVE | Summary: Generic protein-binding IPI from PMID:21782231 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21810480 AWP1 binds to tumor necrosis factor receptor-associated fact... | MODIFY | Summary: PMID:21810480 reports a TRAF2 interaction with RIPK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK1) is the informative part of this IPI. Binding of TRAF2 to RIPK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:21810480 AWP1 binds to tumor necrosis factor receptor-associated fact... | REMOVE | Summary: Generic protein-binding IPI from PMID:21810480 (partner UniProtKB:Q6FIF0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | MODIFY | Summary: PMID:21903422 reports a TRAF2 interaction with RIPK2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK2) is the informative part of this IPI. Binding of TRAF2 to RIPK2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein-binding IPI from PMID:21903422 (partner UniProtKB:P70191). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein-binding IPI from PMID:21903422 (partner UniProtKB:Q7Z434). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein-binding IPI from PMID:21903422 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21903422 Mapping a dynamic innate immunity protein interaction networ... | REMOVE | Summary: Generic protein-binding IPI from PMID:21903422 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | MODIFY | Summary: PMID:21988832 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | MODIFY | Summary: PMID:21988832 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein-binding IPI from PMID:21988832 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:22095282 Arginine methylation-dependent regulation of ASK1 signaling ... | MODIFY | Summary: PMID:22095282 reports a TRAF2 interaction with MAP3K5/ASK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K5/ASK1) is the informative part of this IPI. Binding of TRAF2 to MAP3K5/ASK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:22904686 The germinal center kinase TNIK is required for canonical NF... | MODIFY | Summary: PMID:22904686 reports a TRAF2 interaction with TNIK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNIK) is the informative part of this IPI. Binding of TRAF2 to TNIK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:23088713 Protein interactions of the transcription factor Hoxa1. | REMOVE | Summary: Generic protein-binding IPI from PMID:23088713 (partner UniProtKB:P09022). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:23332158 NleB, a bacterial effector with glycosyltransferase activity... | REMOVE | Summary: Generic protein-binding IPI from PMID:23332158 (partner UniProtKB:P04406). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:23524849 OTUB1 modulates c-IAP1 stability to regulate signalling path... | MODIFY | Summary: PMID:23524849 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:23524849 OTUB1 modulates c-IAP1 stability to regulate signalling path... | MODIFY | Summary: PMID:23524849 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:23890813 Rotavirus NSP1 inhibits interferon induced non-canonical NFΞΊ... | REMOVE | Summary: Generic protein-binding IPI from PMID:23890813 (partner UniProtKB:P89055). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:23955153 Pathogen blocks host death receptor signalling by arginine G... | MODIFY | Summary: PMID:23955153 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic protein-binding IPI from PMID:24658140 (partner UniProtKB:P00533). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:24722188 Protein interaction network of alternatively spliced isoform... | REMOVE | Summary: Generic protein-binding IPI from PMID:24722188 (partner UniProtKB:O43741). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:24722188 Protein interaction network of alternatively spliced isoform... | REMOVE | Summary: Generic protein-binding IPI from PMID:24722188 (partner UniProtKB:X5D778). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25029497 FBXO7 Y52C polymorphism as a potential protective factor in ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25029497 (partner UniProtKB:Q9Y3I1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: PMID:25241761 reports a TRAF2 interaction with ERN1/IRE1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (ERN1/IRE1) is the informative part of this IPI. Binding of TRAF2 to ERN1/IRE1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25241761 (partner UniProtKB:P09211). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25241761 (partner UniProtKB:P46527). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25241761 (partner UniProtKB:Q05516). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25241761 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: PMID:25241761 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: PMID:25241761 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein-binding IPI from PMID:25241761 (partner UniProtKB:Q9UKG1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25260751 The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in respon... | MODIFY | Summary: PMID:25260751 reports a TRAF2 interaction with rat MAP3K1/MEKK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (rat MAP3K1/MEKK1) is the informative part of this IPI. Binding of TRAF2 to rat MAP3K1/MEKK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:B2R8Y4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:G2XKQ0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O43741). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O60437). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O60941). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O75604). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O76041). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:O95999). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P07947). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P21580). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P22415). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P24278). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | MODIFY | Summary: PMID:25416956 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P29972). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P54253). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P54725). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:P57682). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q01844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q02930-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q06547). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q08117). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q0D2K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q12805). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q12815). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q13526). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | MODIFY | Summary: PMID:25416956 reports a TRAF2 interaction with RIPK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK1) is the informative part of this IPI. Binding of TRAF2 to RIPK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q15560). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q16649). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q16656). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q2KHT4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q32MK9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q53EP0-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q53FD0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q5GFL6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q5T124). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q5T8I9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q63HK5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q6BCY4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q6NX49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q6NYC8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q6PF18). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q6ZS27-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q86SE9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q86VK4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q86X59). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q86Y33). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q86YD7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8IV13). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8IWZ5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8IYX8-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N2X6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N5N6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N6N6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N720). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N9N2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8N9N5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8NA54). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8NEC5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8TD31-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8WWW0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q8WWZ3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q92917). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96CG3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96CV8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96IX9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96IZ5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96JS3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96MN9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q96NC0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | MODIFY | Summary: PMID:25416956 reports a TRAF2 interaction with MAP3K14/NIK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K14/NIK) is the informative part of this IPI. Binding of TRAF2 to MAP3K14/NIK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q99618). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BRJ7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BRP7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BSW7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BT49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BV90). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BVG8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BXF9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9BXY8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9GZQ4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9GZU8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9H0I2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9H0W8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9H788). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9H875). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9H8Y8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9HC52). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9NRN7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9NTX7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9NVL8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9NX65). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9NZD8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9P2K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9UHB7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9UHB7-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9Y2J4-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein-binding IPI from PMID:25416956 (partner UniProtKB:Q9Y5U2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25502805 A massively parallel pipeline to clone DNA variants and exam... | MODIFY | Summary: PMID:25502805 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:25609706 Aminopeptidase P3, a new member of the TNF-TNFR2 signaling c... | REMOVE | Summary: Generic protein-binding IPI from PMID:25609706 (partner UniProtKB:Q9NQH7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: Generic protein-binding IPI from PMID:25910212 (partner UniProtKB:O95999). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | MODIFY | Summary: PMID:25910212 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: Generic protein-binding IPI from PMID:25910212 (partner UniProtKB:P46527). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: Generic protein-binding IPI from PMID:25910212 (partner UniProtKB:Q12805). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: Generic protein-binding IPI from PMID:25910212 (partner UniProtKB:Q5JVL4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: Generic protein-binding IPI from PMID:25910212 (partner UniProtKB:Q96JS3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:A0A0S2Z3N6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:A0A0S2Z3V1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:A0A0S2Z6P0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:B4DE54). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:O15169). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:Q12805). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein-binding IPI from PMID:26871637 (partner UniProtKB:Q8N9N5-7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:27135603 A TRAF-like motif of the inducible costimulator ICOS control... | REMOVE | Summary: Generic protein-binding IPI from PMID:27135603 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:29329668 Helicobacter pylori induces direct activation of the lymphot... | MODIFY | Summary: PMID:29329668 reports a TRAF2 interaction with LTBR/TNFRSF3. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (LTBR/TNFRSF3) is the informative part of this IPI. Binding of TRAF2 to LTBR/TNFRSF3 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:29844572 RANK-c attenuates aggressive properties of ER-negative breas... | MODIFY | Summary: PMID:29844572 reports a TRAF2 interaction with TNFRSF11A/RANK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF11A/RANK) is the informative part of this IPI. Binding of TRAF2 to TNFRSF11A/RANK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:29844572 RANK-c attenuates aggressive properties of ER-negative breas... | MODIFY | Summary: PMID:29844572 reports a TRAF2 interaction with TNFRSF11A/RANK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF11A/RANK) is the informative part of this IPI. Binding of TRAF2 to TNFRSF11A/RANK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:29883609 PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylat... | REMOVE | Summary: Generic protein-binding IPI from PMID:29883609 (partner UniProtKB:Q9Y572). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein-binding IPI from PMID:29892012 (partner UniProtKB:P48380). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein-binding IPI from PMID:29892012 (partner UniProtKB:Q8TBB1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein-binding IPI from PMID:29892012 (partner UniProtKB:Q9H8Y8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30402268 Haploinsufficiency of A20 impairs protein-protein interactom... | REMOVE | Summary: Generic protein-binding IPI from PMID:30402268 (partner UniProtKB:P21580). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:P21580). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q12815). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | MODIFY | Summary: PMID:30561431 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | MODIFY | Summary: PMID:30561431 reports a TRAF2 interaction with RIPK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK1) is the informative part of this IPI. Binding of TRAF2 to RIPK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q13627). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | MODIFY | Summary: PMID:30561431 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q6FIF0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q7Z434). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | REMOVE | Summary: Generic protein-binding IPI from PMID:30561431 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:O60941). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:O76041). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:P21580). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | MODIFY | Summary: PMID:31515488 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:P46527). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:P54725). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q6NX49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q92917). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q96JS3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q9BT49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q9NZD8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein-binding IPI from PMID:31515488 (partner UniProtKB:Q9UKG1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31617661 Global Interactome Mapping of Mitochondrial Intermembrane Sp... | REMOVE | Summary: Generic protein-binding IPI from PMID:31617661 (partner UniProtKB:O43464). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein-binding IPI from PMID:31980649 (partner UniProtKB:P00533). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | MODIFY | Summary: PMID:31980649 reports a TRAF2 interaction with MAP3K14/NIK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K14/NIK) is the informative part of this IPI. Binding of TRAF2 to MAP3K14/NIK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:A0A0A0MR80). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:A0A384ME25). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:C9JRZ8-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:E9PSE9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O00233). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O00463). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O15273). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O15353). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O43167). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O43708). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O43741). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O60437). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O60941-5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O75367). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O75604). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O75808). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O75928-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O76041). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95363). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95863). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95872). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95990-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95994). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95995). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:O95999). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P00540). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P07947). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P09067). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P10599). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P12268). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P13682). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P15622-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P20618). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P21580). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: PMID:32296183 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P26196). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P28676). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P35227). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P35711-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P41182). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P41225). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P47897). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P48380). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P48751). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P49639). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P49711). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P51800-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P53672). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P54253). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P54725). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P55040). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P55081). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P56279). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P57055). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P57682). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P63165). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:P78317). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q02930-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q05516). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q06547). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q07002). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q08426). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q08495). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q0D2K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q12805). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q13064). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: PMID:32296183 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q13526). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: PMID:32296183 reports a TRAF2 interaction with RIPK1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK1) is the informative part of this IPI. Binding of TRAF2 to RIPK1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q13671). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q13895). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q14119). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q14142). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q14511-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q14687). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q15052). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q15560). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: PMID:32296183 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q15742). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q16512). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q16543). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q16656-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q17RB8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q17RL8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q2TAL8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q2TBE0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q3B820). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q3MJ62). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q3SY00). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q496Y0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q49AN0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q4G0R1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q4V328). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q4VC44). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q53FD0-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q53TS8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5HYW2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5JVL4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5T124-6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5T5P2-6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5T619). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5T7P8-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5T8A7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5TAP6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q5W5X9-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q63ZY3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6B0K9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6BCY4-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6GPH6-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6NX45). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6PF18). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6X4W1-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6ZN55-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q6ZSB9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7KZS0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7L5A3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7Z3I7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7Z434). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7Z4V0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q7Z5V6-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86TN4-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86UR1-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86VK4-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86XT4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86Y33-5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q86YD7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IVT2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IVT4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IXW0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IY51). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IYH5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IYS8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8IZU1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8N3R9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8N6R0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8N8B7-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8N9N2-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8N9N5-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8NHY3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8NI38). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8TAU3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8TBB1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8TBE0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8TD31-3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8WTU0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q8WYQ4-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q92529). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q92558). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q92917). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q92997). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96BZ8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96CG3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96EK7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96HA1-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96IZ5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96JC9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96JP2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96MM6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96MP5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96MY7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96NC0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96NU1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96PC2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q96S90). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q99618). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q99633). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BRJ7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BRP7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BRR0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BRU9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BSW7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BT49). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BUI4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BVG8-5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BWG6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BXF9). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9BXY8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9C086). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9H0I2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9H0W8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9H5Z6-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9H8Y8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9HAK2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9HBE1-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9HC52). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9HC98-4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9NRE2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9NRN7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9NTX7-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9NVF7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9NZD8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9UBU8-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9UHP6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9UIF8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9UJ78-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9UN79). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y247). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y3D2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y4B4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y4C2-2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:Q9Y6H1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:32296183 (partner UniProtKB:X5D778). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | MODIFY | Summary: PMID:32707033 reports a TRAF2 interaction with RIPK2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (RIPK2) is the informative part of this IPI. Binding of TRAF2 to RIPK2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by protein kinase binding (GO:0019901), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: protein kinase binding |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein-binding IPI from PMID:32707033 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein-binding IPI from PMID:32814053 (partner UniProtKB:P42858). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein-binding IPI from PMID:32814053 (partner UniProtKB:P54253). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:O43464). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:O95999). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with TNFRSF1B/TNFR2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF1B/TNFR2) is the informative part of this IPI. Binding of TRAF2 to TNFRSF1B/TNFR2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with CD27/TNFRSF7. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD27/TNFRSF7) is the informative part of this IPI. Binding of TRAF2 to CD27/TNFRSF7 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with LTBR/TNFRSF3. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (LTBR/TNFRSF3) is the informative part of this IPI. Binding of TRAF2 to LTBR/TNFRSF3 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with BIRC3/cIAP2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC3/cIAP2) is the informative part of this IPI. Binding of TRAF2 to BIRC3/cIAP2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: PMID:33961781 reports a TRAF2 interaction with BIRC2/cIAP1. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (BIRC2/cIAP1) is the informative part of this IPI. Binding of TRAF2 to BIRC2/cIAP1 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by ubiquitin protein ligase binding (GO:0031625), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: ubiquitin protein ligase binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q6FIF0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q92844). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q9NVF7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q9UHD2). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein-binding IPI from PMID:33961781 (partner UniProtKB:Q9Y4K3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:35914814 Chr21 protein-protein interactions: enrichment in proteins i... | REMOVE | Summary: Generic protein-binding IPI from PMID:35914814 (partner UniProtKB:Q13627). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:A4D2P6). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:O43464). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:O75970). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:P78352). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q02410). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q07157). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q12959). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q14005). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q14160). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q15700). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q5T2W1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q68DX3). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q86UL8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q86UT5). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q8N448). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q8NI35). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q8TBB1). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q92796). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q92997). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q96QZ7). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q99767). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q9C0E4). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q9H8Y8). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q9P202). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Generic protein-binding IPI from PMID:36115835 (partner UniProtKB:Q9Y3R0). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:36217029 A proteome-scale map of the SARS-CoV-2-human contactome. | REMOVE | Summary: Generic protein-binding IPI from PMID:36217029 (partner UniProtKB:P0DTD1-PRO_0000449631). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | MODIFY | Summary: PMID:40205054 reports a TRAF2 interaction with TNFRSF1B/TNFR2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF1B/TNFR2) is the informative part of this IPI. Binding of TRAF2 to TNFRSF1B/TNFR2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | MODIFY | Summary: PMID:40205054 reports a TRAF2 interaction with CD40/TNFRSF5. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD40/TNFRSF5) is the informative part of this IPI. Binding of TRAF2 to CD40/TNFRSF5 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein-binding IPI from PMID:40205054 (partner UniProtKB:P54725). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | MODIFY | Summary: PMID:8069916 reports a TRAF2 interaction with TNFRSF1B/TNFR2. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF1B/TNFR2) is the informative part of this IPI. Binding of TRAF2 to TNFRSF1B/TNFR2 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | REMOVE | Summary: Generic protein-binding IPI from PMID:8069916 (partner UniProtKB:Q13077). The interaction may well be real, but the annotation conveys no molecular function. Reason: Per the protein-binding policy, bare GO:0005515 is uninformative. The partner is not one of the receptor, cIAP, MAP3K, kinase or adaptor partners through which TRAF2's established signaling-adaptor role is expressed, so no more informative molecular function can be stated from this record alone. Removal records that the term is uninformative, not that the interaction is false. |
| GO:0005515 protein binding | IPI PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | MODIFY | Summary: PMID:8565075 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | MODIFY | Summary: PMID:9020361 reports a TRAF2 interaction with TRADD. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TRADD) is the informative part of this IPI. Binding of TRAF2 to TRADD is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by signaling adaptor activity (GO:0035591), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: signaling adaptor activity |
| GO:0005515 protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | MODIFY | Summary: PMID:9020361 reports a TRAF2 interaction with MAP3K14/NIK. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (MAP3K14/NIK) is the informative part of this IPI. Binding of TRAF2 to MAP3K14/NIK is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by mitogen-activated protein kinase kinase kinase binding (GO:0031435), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: mitogen-activated protein kinase kinase kinase binding |
| GO:0005515 protein binding | IPI PMID:9153189 ATAR, a novel tumor necrosis factor receptor family member, ... | MODIFY | Summary: PMID:9153189 reports a TRAF2 interaction with TNFRSF14/HVEM. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (TNFRSF14/HVEM) is the informative part of this IPI. Binding of TRAF2 to TNFRSF14/HVEM is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:9418902 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-... | MODIFY | Summary: PMID:9418902 reports a TRAF2 interaction with mouse TNFRSF9/4-1BB. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (mouse TNFRSF9/4-1BB) is the informative part of this IPI. Binding of TRAF2 to mouse TNFRSF9/4-1BB is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005515 protein binding | IPI PMID:9692890 The TNF receptor family member CD27 signals to Jun N-termina... | MODIFY | Summary: PMID:9692890 reports a TRAF2 interaction with CD27/TNFRSF7. Generic protein binding does not say what kind of partner is bound; the partner identity does. Reason: The partner (CD27/TNFRSF7) is the informative part of this IPI. Binding of TRAF2 to CD27/TNFRSF7 is a well-documented step in TNF receptor superfamily signaling and is captured more informatively by tumor necrosis factor receptor binding (GO:0005164), a term this review already carries or proposes for TRAF2. The interaction itself is not disputed. Proposed replacements: tumor necrosis factor receptor binding |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8862184 | MARK AS OVER ANNOTATED | Summary: Reactome places the USP48-TRAF2 deubiquitination reaction in the nucleoplasm because of USP48, not because of evidence for nuclear TRAF2. Reason: UniProt curates TRAF2 as cytoplasmic from experimental data, and all well-characterised TRAF2 functions are at the cytoplasmic face of receptors or in cytosolic complexes. A nuclear TRAF2 pool is not excluded, but this pathway-database compartment assignment is not evidence for it. Supporting Evidence: Reactome:R-HSA-8862184 USP48 can interact with TRAF2 file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | MODIFY | Summary: TRAF2 is cytoplasmic (UniProt, experimental; PAINT IBA at PTN008938480 across the TRAF family). Reason: Correct but general. The evidence supports the more specific cytosol (GO:0005829) and cytoplasmic side of plasma membrane (GO:0009898), both already carried by the gene. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH Sources checked: PANTHER:PTN008938480 SUPPORTS TRANSFER Deep TRAF-family node seeded by experimental cytoplasm annotations from TRAF1-6 and Drosophila/Dictyostelium TRAFs, including TRAF2 itself. The node placement is sound; for TRAF2 the experimental data allow the more specific cytosol and cytoplasmic side of plasma membrane. Proposed replacements: cytosol cytoplasmic side of plasma membrane Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005737 cytoplasm | IDA PMID:15383523 TRAF3 forms heterotrimers with TRAF2 and modulates its abili... | MODIFY | Summary: TRAF2 is cytoplasmic (UniProt, experimental; PAINT IBA at PTN008938480 across the TRAF family). Reason: Correct but general. The evidence supports the more specific cytosol (GO:0005829) and cytoplasmic side of plasma membrane (GO:0009898), both already carried by the gene. Proposed replacements: cytosol cytoplasmic side of plasma membrane Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005737 cytoplasm | IDA PMID:19150425 PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitm... | MODIFY | Summary: TRAF2 is cytoplasmic (UniProt, experimental; PAINT IBA at PTN008938480 across the TRAF family). Reason: Correct but general. The evidence supports the more specific cytosol (GO:0005829) and cytoplasmic side of plasma membrane (GO:0009898), both already carried by the gene. Proposed replacements: cytosol cytoplasmic side of plasma membrane Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | MODIFY | Summary: TRAF2 is cytoplasmic (UniProt, experimental; PAINT IBA at PTN008938480 across the TRAF family). Reason: Correct but general. The evidence supports the more specific cytosol (GO:0005829) and cytoplasmic side of plasma membrane (GO:0009898), both already carried by the gene. Proposed replacements: cytosol cytoplasmic side of plasma membrane Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | IC PMID:40097387 Ubiquitination of gasdermin D N-terminal domain directs its ... | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139952 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-140978 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-141159 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3371360 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3465429 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3465448 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357757 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357776 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357780 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357828 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357845 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357860 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357904 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5357928 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5634221 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668414 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668417 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668454 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668481 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668534 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5668543 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5675456 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676593 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676595 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676596 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676597 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5676598 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5693055 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5693108 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5696627 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-75240 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-83582 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-83656 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8869456 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-918230 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933525 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933527 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933530 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933537 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-933538 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9693929 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9697747 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9697750 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705145 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9705323 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9750946 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9793679 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9793680 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796342 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796346 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9796379 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9815501 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817362 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817397 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817400 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817411 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9818789 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9818975 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9819106 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9824874 | ACCEPT | Summary: TRAF2 is a soluble cytosolic adaptor that is recruited from the cytosol to receptor complexes; Reactome places TRAF2-containing reactions in the cytosol. Reason: Consistent with the experimentally determined cytoplasmic location and with the lack of transmembrane or organelle-targeting features. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, |
| GO:0005886 plasma membrane | NAS PMID:21081755 Solution of the structure of the TNF-TNFR2 complex. | MODIFY | Summary: Author statement placing TRAF2 at the plasma membrane in TNF receptor signaling. Reason: TRAF2 is a peripheral protein recruited to the cytoplasmic tails of receptors, so cytoplasmic side of plasma membrane (GO:0009898), which the gene already carries, is the precise term. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005886 plasma membrane | NAS PMID:33495445 A conformation-selective monoclonal antibody against a small... | MODIFY | Summary: Author statement placing TRAF2 at the plasma membrane in TNF receptor signaling. Reason: TRAF2 is a peripheral protein recruited to the cytoplasmic tails of receptors, so cytoplasmic side of plasma membrane (GO:0009898), which the gene already carries, is the precise term. Proposed replacements: cytoplasmic side of plasma membrane Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0005938 cell cortex | IEA GO_REF:0000107 | UNDECIDED | Summary: Projected from rat Traf2 by Ensembl Compara orthology. Reason: No human or mouse evidence for a specific cell-cortex pool was found; the source rat annotation could not be traced. Not contradicted, but not supported either. |
| GO:0006954 inflammatory response | NAS PMID:20194223 Transmembrane TNF-alpha: structure, function and interaction... | KEEP AS NON CORE | Summary: Statement from a TNF review that TRAF2-mediated TNF signaling drives inflammation. Reason: TRAF2 contributes to inflammatory responses through TNF/NF-kappaB signaling (and loss of TRAF2 in keratinocytes causes TNF-driven skin inflammation), but this is an organism-level outcome of its adaptor role, not a core function. Supporting Evidence: PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0006954 inflammatory response | NAS PMID:33800290 The Role of Tumor Necrosis Factor Alpha (TNF-Ξ±) in Autoimmun... | KEEP AS NON CORE | Summary: Statement from a TNF review that TRAF2-mediated TNF signaling drives inflammation. Reason: TRAF2 contributes to inflammatory responses through TNF/NF-kappaB signaling (and loss of TRAF2 in keratinocytes causes TNF-driven skin inflammation), but this is an organism-level outcome of its adaptor role, not a core function. Supporting Evidence: PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | MODIFY | Summary: Generic signal transduction. Reason: True but general; TRAF2 acts in tumor necrosis factor-mediated signaling (GO:0033209), which the gene already carries with IBA and experimental support. Proposed replacements: tumor necrosis factor-mediated signaling pathway Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0007165 signal transduction | TAS PMID:8702708 Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB... | MODIFY | Summary: Generic signal transduction. Reason: True but general; TRAF2 acts in tumor necrosis factor-mediated signaling (GO:0033209), which the gene already carries with IBA and experimental support. Proposed replacements: tumor necrosis factor-mediated signaling pathway Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0007249 canonical NF-kappaB signal transduction | IEA GO_REF:0000107 | ACCEPT | Summary: Projected from rat. TRAF2 is a component of TNFR-proximal complexes that activate IKK and canonical NF-kappaB. Reason: Consistent with human experimental evidence that TRAF2 contributes to TNF-induced NF-kappaB activation. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0008270 zinc ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: TRAF2 contains a RING-type and two TRAF-type zinc fingers. Reason: Zinc coordination is structural; it is true but not a functional activity in its own right. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt /note="RING-type" file:human/TRAF2/TRAF2-uniprot.txt /note="TRAF-type 1" |
| GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors | NAS PMID:36380021 Death by TNF: a road to inflammation. | KEEP AS NON CORE | Summary: TRAF2 is recruited with TRADD and RIPK1 into TNFR1 complex I, and is reported in complex II; it is part of the death-receptor signaling machinery. Reason: TRAF2 sits in the receptor complexes of this pathway, but its main effect there is to restrain cell death by recruiting cIAPs; it is not a death executor. Non-core. Supporting Evidence: PMID:36380021 allowing the subsequent recruitment of TNFR-associated factor 2 (TRAF2) and of the ubiquitin ligases cellular inhibitor of apoptosis protein 1 (cIAP1), cIAP2 |
| GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage | NAS PMID:21458669 NEMO and RIP1 control cell fate in response to extensive DNA... | UNDECIDED | Summary: Author statement from a study of NEMO/RIP1 and TNF feed-forward signaling after DNA damage. Reason: The cached abstract does not mention TRAF2, and the full text was not available, so the basis of the statement could not be checked. |
| GO:0009898 cytoplasmic side of plasma membrane | IC PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | ACCEPT | Summary: TRAF2 binds the cytoplasmic domains of TNF receptor superfamily members and so acts at the cytoplasmic side of the plasma membrane. Reason: Supported by direct binding to the CD40 cytoplasmic domain and by recruitment to ligand-engaged receptors. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0009898 cytoplasmic side of plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 binds the cytoplasmic domains of TNF receptor superfamily members and so acts at the cytoplasmic side of the plasma membrane. Reason: Supported by direct binding to the CD40 cytoplasmic domain and by recruitment to ligand-engaged receptors. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0009898 cytoplasmic side of plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: TRAF2 binds the cytoplasmic domains of TNF receptor superfamily members and so acts at the cytoplasmic side of the plasma membrane. Reason: Supported by direct binding to the CD40 cytoplasmic domain and by recruitment to ligand-engaged receptors. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ARBA rule; TRAF2 signaling activates NF-kappaB and AP-1 dependent transcription. Reason: An indirect consequence of signaling, too broad to describe TRAF2 function; kept as non-core. |
| GO:0012501 programmed cell death | IEA GO_REF:0000117 | MODIFY | Summary: ARBA rule placing TRAF2 in programmed cell death. Reason: TRAF2 does not execute cell death; it regulates whether TNF-family receptors give survival or apoptosis. Regulation of apoptotic process (GO:0042981), already carried with IDA, describes this correctly. Proposed replacements: regulation of apoptotic process Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0012506 vesicle membrane | IEA GO_REF:0000107 | UNDECIDED | Summary: Projected from mouse Traf2 by orthology. Reason: TRAF2 can traffic with internalised receptors, and a cIAP1/TRAF2 complex moves to a Ubc6-containing compartment after TNF, but the specific mouse vesicle-membrane evidence was not traced. |
| GO:0016567 protein ubiquitination | IEA GO_REF:0000041 | MODIFY | Summary: UniPathway mapping to protein ubiquitination. Reason: True but general; the experimental evidence specifies K63-linked chains, so protein K63-linked ubiquitination (GO:0070534), already carried, is the better term. Proposed replacements: protein K63-linked ubiquitination Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). |
| GO:0019899 enzyme binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: TRAF2 binds GSTP1, which restrains TRAF2-ASK1 signaling. Reason: Binding is direct and regulatory, but the enzyme partner acts on TRAF2 rather than TRAF2 acting through it; non-core. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0019899 enzyme binding | IPI PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | KEEP AS NON CORE | Summary: TRAF2 binds GSTP1, which restrains TRAF2-ASK1 signaling. Reason: Binding is direct and regulatory, but the enzyme partner acts on TRAF2 rather than TRAF2 acting through it; non-core. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 binds and recruits protein kinases, including IRE1 (ERN1), RIPK1 and the MAP3Ks ASK1, MEKK1 and NIK. Reason: Bringing kinases into receptor-proximal complexes is part of its adaptor function; the IRE1 cytoplasmic region binds TRAF2 directly. Supporting Evidence: PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:0019901 protein kinase binding | IPI PMID:10650002 Coupling of stress in the ER to activation of JNK protein ki... | ACCEPT | Summary: TRAF2 binds and recruits protein kinases, including IRE1 (ERN1), RIPK1 and the MAP3Ks ASK1, MEKK1 and NIK. Reason: Bringing kinases into receptor-proximal complexes is part of its adaptor function; the IRE1 cytoplasmic region binds TRAF2 directly. Supporting Evidence: PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:0019903 protein phosphatase binding | IPI PMID:15696169 Selective regulation of tumor necrosis factor-induced Erk si... | KEEP AS NON CORE | Summary: TCPTP (PTPN2) interacts with TRAF2 and modulates TNF-induced Src/ERK signaling. Reason: A regulatory interaction in which the phosphatase acts on TRAF2-dependent signaling; non-core. Supporting Evidence: PMID:15696169 TCPTP interacted with the adaptor protein TRAF2, and dephosphorylated and inactivated Src tyrosine kinases to suppress downstream signaling through extracellular signal-regulated kinases and production of interleukin 6. |
| GO:0023035 CD40 signaling pathway | IDA PMID:15708970 TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an ... | ACCEPT | Summary: TRAF2 (with TRAF5) mediates CD40 activation of canonical and non-canonical NF-kappaB. Reason: CD40 is a prototypical TRAF2-binding receptor; the process annotation follows from direct receptor binding and mutant analysis. Supporting Evidence: PMID:15708970 Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | MODIFY | Summary: TRAF2 bridges receptors (directly or via TRADD) to cIAP1/2, MAP3Ks and other signaling enzymes. Reason: Correct, but the adaptor acts within signaling pathways, so the descendant signaling adaptor activity (GO:0035591; IBA at PTN008301857) is the precise term. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | MODIFY | Summary: TRAF2 bridges receptors (directly or via TRADD) to cIAP1/2, MAP3Ks and other signaling enzymes. Reason: Correct, but the adaptor acts within signaling pathways, so the descendant signaling adaptor activity (GO:0035591; IBA at PTN008301857) is the precise term. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0030674 protein-macromolecule adaptor activity | IEA GO_REF:0000117 | MODIFY | Summary: TRAF2 bridges receptors (directly or via TRADD) to cIAP1/2, MAP3Ks and other signaling enzymes. Reason: Correct, but the adaptor acts within signaling pathways, so the descendant signaling adaptor activity (GO:0035591; IBA at PTN008301857) is the precise term. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0030674 protein-macromolecule adaptor activity | IPI PMID:20447407 Asymmetric recruitment of cIAPs by TRAF2. | MODIFY | Summary: TRAF2 bridges receptors (directly or via TRADD) to cIAP1/2, MAP3Ks and other signaling enzymes. Reason: Correct, but the adaptor acts within signaling pathways, so the descendant signaling adaptor activity (GO:0035591; IBA at PTN008301857) is the precise term. Proposed replacements: signaling adaptor activity Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0031435 mitogen-activated protein kinase kinase kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: Projected from rat. Human TRAF2 binds ASK1/MAP3K5, MEKK1/MAP3K1 and NIK/MAP3K14 in TNF signaling. Reason: MAP3K recruitment links TRAF2 to JNK and NF-kappaB activation; consistent with direct IRE1-TRAF2-ASK1 complex data. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0031625 ubiquitin protein ligase binding | IDA PMID:23951545 MAVS recruits multiple ubiquitin E3 ligases to activate anti... | ACCEPT | Summary: TRAF2 binds the E3 ligases cIAP1 and cIAP2 (and others such as TRIM37 and Parkin). Reason: Recruitment of cIAP E3 ligases is the mechanism by which TRAF2 couples receptors to ubiquitin signaling; reconstitution maps the binding. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | ACCEPT | Summary: TRAF2 binds the E3 ligases cIAP1 and cIAP2 (and others such as TRIM37 and Parkin). Reason: Recruitment of cIAP E3 ligases is the mechanism by which TRAF2 couples receptors to ubiquitin signaling; reconstitution maps the binding. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0031996 thioesterase binding | IPI PMID:11279055 A diverse family of proteins containing tumor necrosis facto... | KEEP AS NON CORE | Summary: IPI with USP7 (Q93009), a MATH-domain deubiquitinase, from a study of TRAF-domain proteins. Reason: The interaction is plausible but its function for TRAF2 is unknown; non-core. |
| GO:0032743 positive regulation of interleukin-2 production | IMP PMID:15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activ... | KEEP AS NON CORE | Summary: RNAi against TRAF2 in T cells reduces TCR-dependent IKK activation and IL-2 production. Reason: Experimentally supported in human T cells, but cytokine output is a consequence of TRAF2's adaptor role in NF-kappaB activation, not its core activity. Supporting Evidence: PMID:15125833 RNAi-mediated silencing of MALT1, TAK1, TRAF6, and TRAF2 suppressed TCR-dependent IKK activation and interleukin-2 production in T cells. |
| GO:0032813 tumor necrosis factor receptor superfamily binding | IEA GO_REF:0000117 | MODIFY | Summary: ARBA rule for TNFR superfamily binding. Reason: True but general; the gene carries the descendant tumor necrosis factor receptor binding (GO:0005164) with direct evidence. Proposed replacements: tumor necrosis factor receptor binding Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | MODIFY | Summary: Generic protein-containing complex, projected from rat. Reason: True but uninformative; TRAF2's complexes are TNF receptor superfamily signaling complexes (GO:0002947). Proposed replacements: tumor necrosis factor receptor superfamily complex Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | IMP PMID:12296995 TAK1-dependent activation of AP-1 and c-Jun N-terminal kinas... | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | NAS PMID:20194223 Transmembrane TNF-alpha: structure, function and interaction... | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0033209 tumor necrosis factor-mediated signaling pathway | NAS PMID:33495441 Structural insights into the disruption of TNF-TNFR1 signall... | ACCEPT | Summary: TRAF2 is a core component of TNF signaling through TNFR1 (via TRADD) and TNFR2 (directly), activating JNK and NF-kappaB and supplying anti-apoptotic signals. PAINT places this process at node PTN000805720. Reason: Directly supported by TRAF2 loss-of-function and by its recruitment to TNF receptor complexes; core process. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0034351 negative regulation of glial cell apoptotic process | IEA GO_REF:0000107 | UNDECIDED | Summary: Projected from rat Traf2. Reason: TRAF2 generally promotes survival through NF-kappaB, but the glial-specific rat evidence was not traced, and a cell-type-specific term cannot be judged without it. |
| GO:0034976 response to endoplasmic reticulum stress | NAS PMID:10650002 Coupling of stress in the ER to activation of JNK protein ki... | KEEP AS NON CORE | Summary: IRE1 recruits TRAF2 during ER stress, linking the unfolded protein response to JNK. Reason: TRAF2 acts in this response as the adaptor between IRE1 and ASK1; a real but stimulus-specific deployment. Supporting Evidence: PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:0035591 signaling adaptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 is a signaling adaptor that links ligand-engaged TNF receptor superfamily members to cIAP E3 ligases, MAP3Ks and IKK. PAINT places this activity at node PTN008301857. Reason: This is the core molecular activity of TRAF2, directly supported by reconstitution of the cIAP1-TRAF2 complex and receptor-binding data. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0035591 signaling adaptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: TRAF2 is a signaling adaptor that links ligand-engaged TNF receptor superfamily members to cIAP E3 ligases, MAP3Ks and IKK. PAINT places this activity at node PTN008301857. Reason: This is the core molecular activity of TRAF2, directly supported by reconstitution of the cIAP1-TRAF2 complex and receptor-binding data. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0035631 CD40 receptor complex | IEA GO_REF:0000107 | ACCEPT | Summary: Projected from mouse Traf2 (same subfamily). Human TRAF2 binds CD40 directly. Reason: Consistent with direct human data. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0035631 CD40 receptor complex | ISS GO_REF:0000024 | ACCEPT | Summary: Projected from mouse Traf2 (same subfamily). Human TRAF2 binds CD40 directly. Reason: Consistent with direct human data. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0038061 non-canonical NF-kappaB signal transduction | IDA PMID:8565075 TRADD-TRAF2 and TRADD-FADD interactions define two distinct ... | ACCEPT | Summary: TRAF2 participates in non-canonical NF-kappaB signaling, both downstream of CD40 and as part of the TRAF2-TRAF3-cIAP assembly that controls NIK. Reason: Experimentally supported involvement in the pathway, though the original reference (TRADD-TRAF2) is mainly about TNFR1 signaling. Supporting Evidence: PMID:15708970 Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. |
| GO:0042110 T cell activation | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | KEEP AS NON CORE | Summary: Internalised CD27 recruits TRAF2 and SHP-1 to modulate TCR/CD28 signals in naive T cells. Reason: Supported, but T cell activation is a cell-level outcome of a specific receptor's signaling; non-core. Supporting Evidence: PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:0042802 identical protein binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:20562859 Network organization of the human autophagy system. | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:30561431 A protein-protein interaction map of the TNF-induced NF-ΞΊB s... | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:8069916 A novel family of putative signal transducers associated wit... | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042802 identical protein binding | IPI PMID:9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF,... | KEEP AS NON CORE | Summary: TRAF2 forms homotrimers through its coiled-coil/TRAF domain, and the RING-zinc finger region dimerises in vitro. Reason: Self-association is a structural requirement for receptor clustering and cIAP binding, not an activity in itself. Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt Homotrimer (PubMed:8069916). PMID:20447407 Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. |
| GO:0042981 regulation of apoptotic process | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 controls survival versus apoptosis downstream of TNF-family receptors, mainly by suppressing death. Reason: Directly supported; the general regulation term is appropriate because TRAF2 can act both anti- and pro-apoptotically depending on the receptor. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0042981 regulation of apoptotic process | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 controls survival versus apoptosis downstream of TNF-family receptors, mainly by suppressing death. Reason: Directly supported; the general regulation term is appropriate because TRAF2 can act both anti- and pro-apoptotically depending on the receptor. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0043120 tumor necrosis factor binding | IPI PMID:23429285 EVER2 protein binds TRADD to promote TNF-Ξ±-induced apoptosis... | REMOVE | Summary: IPI with TRADD from a study of EVER2-TRADD in TNFR1 signaling. The paper shows TRAF2 recruitment into TNFR1 complex I. Reason: TNF binding means binding the cytokine itself. TRAF2 is an intracellular adaptor that cannot contact extracellular TNF; co-recovery with a ligand-engaged receptor reflects receptor-complex membership, already captured by tumor necrosis factor receptor superfamily complex (GO:0002947) from the same paper. The annotated partner (TRADD) is not TNF. Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:26458771 Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis thro... | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IDA PMID:29581234 TRAF-interacting protein with forkhead-associated domain (TI... | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IMP PMID:12296995 TAK1-dependent activation of AP-1 and c-Jun N-terminal kinas... | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043123 positive regulation of canonical NF-kappaB signal transduction | IMP PMID:15121867 TRAF family proteins link PKR with NF-kappa B activation. | ACCEPT | Summary: TRAF2 promotes canonical NF-kappaB activation downstream of TNFR1/2, CD40, PKR and other receptors; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Supported by TRAF2 overexpression and loss-of-function data in human cells and by the phylogenetic inference. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. PMID:26458771 In contrast, TIFAB did not repress ΞΊB-site activation after transfection of TRAF2, a functionally related paralog of TRAF6 (Fig. 5 I). TIFAB represses TRAF6-, but not TRAF2-mediated NF-ΞΊB activation, implying that TIFAB selectively inhibits TLR/TRAF6-dependent NF-ΞΊB stimuli while having no effect on TNFR2/TRAF2-dependent NF-ΞΊB stimuli. |
| GO:0043235 signaling receptor complex | IEA GO_REF:0000117 | MODIFY | Summary: ARBA rule for signaling receptor complex. Reason: True but general; TRAF2's receptor complexes are TNF receptor superfamily complexes (GO:0002947). Proposed replacements: tumor necrosis factor receptor superfamily complex Supporting Evidence: PMID:23429285 TRADD recruits TNF receptor-associated factor 2 (TRAF2) protein, which in turn interacts with the E3 ligases' cellular inhibitor of apoptosis protein (cIAP)-1 and cIAP-2 |
| GO:0043254 regulation of protein-containing complex assembly | IMP PMID:11278723 Activation of caspase-12, an endoplastic reticulum (ER) resi... | KEEP AS NON CORE | Summary: TRAF2 is required for ER-stress-induced association of IRE1 with downstream components in a caspase-12 study. Reason: Plausible, as TRAF2 is an assembly scaffold, but the abstract-only record does not allow closer checking; kept as non-core. |
| GO:0043408 regulation of MAPK cascade | IEA GO_REF:0000117 | MODIFY | Summary: ARBA rule for regulation of MAPK cascade. Reason: True but general; the evidence specifies the JNK cascade, so regulation of JNK cascade (GO:0046328), already carried, is the better term. Proposed replacements: regulation of JNK cascade Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0043507 positive regulation of JUN kinase activity | IDA PMID:11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of... | ACCEPT | Summary: TRAF2 is required for TNF-induced JNK activation, via recruitment of MAP3Ks such as ASK1 and MEKK1. Reason: Directly supported by TRAF2 loss-of-function data. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0044877 protein-containing complex binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Projected from mouse/rat Traf2. Reason: TRAF2 binds multi-protein receptor complexes and cIAP-containing assemblies, so the term is true, but it is uninformative beside the specific receptor and E3 binding terms. |
| GO:0045121 membrane raft | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Projected from mouse Traf2, where TRAF2 is recruited with CD40 into membrane rafts. Reason: Consistent with TRAF2's recruitment to clustered receptors at the plasma membrane; a context-specific location, kept as non-core. Supporting Evidence: PMID:9718306 Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and used to finely map TRAF binding regions in the human CD40 cytoplasmic domain. TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain. |
| GO:0046328 regulation of JNK cascade | IEA GO_REF:0000002 | ACCEPT | Summary: TRAF2 is required for TNF-induced JNK activation, via recruitment of MAP3Ks such as ASK1 and MEKK1. Reason: Directly supported by TRAF2 loss-of-function data. Supporting Evidence: PMID:11907583 TRAF2 is required for TNF-alpha-mediated activation of c-Jun N-terminal kinase (JNK), contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,. |
| GO:0046625 sphingolipid binding | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | KEEP AS NON CORE | Summary: Recombinant TRAF2 binds S1P beads, and binding needs the RING domain. Reason: Direct binding is shown, but whether S1P is a physiological TRAF2 cofactor is contested by genetic evidence that Sphk1 is dispensable for TRAF2 function. Supporting Evidence: PMID:20577214 Moreover, recombinant TRAF2 purified from Sf9 insect cells also bound to S1P beads, whereas RIP1 and ΞRING-TRAF2 did not (Supplementary Fig. 7d,e,f). PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0046872 metal ion binding | IEA GO_REF:0000002 | MODIFY | Summary: InterPro-based metal ion binding for the RING/TRAF zinc fingers. Reason: The bound metal is zinc; zinc ion binding (GO:0008270), already carried, is the precise term. Proposed replacements: zinc ion binding Supporting Evidence: file:human/TRAF2/TRAF2-uniprot.txt /note="RING-type" |
| GO:0048255 mRNA stabilization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Projected from mouse Traf2 (same PANTHER subfamily), where TRAF2/TRAF5 act with Act1 in IL-17 receptor signaling, including stabilization of chemokine mRNAs. Reason: Orthology transfer within PTHR10131:SF21 is sound, and the mouse role fits TRAF2's general adaptor function; a receptor-specific context, kept as non-core. |
| GO:0051865 protein autoubiquitination | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | KEEP AS NON CORE | Summary: S1P stimulates autoubiquitination of recombinant TRAF2 purified from insect cells, free of cIAPs. Reason: Supported by in vitro reconstitution, but follows the same caveats as the E3 activity itself. In cells, TRAF2 is also ubiquitinated by cIAP1, so ubiquitinated TRAF2 alone is not evidence of autoubiquitination. Supporting Evidence: PMID:20577214 S1P also stimulated in vitro autoubiquitination of recombinant TRAF2 (Supplementary Fig. 8d). PMID:11907583 Although c-IAP1 bound TRAF2 and TRAF1 in vitro, it ubiquitinated only TRAF2. |
| GO:0051865 protein autoubiquitination | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: S1P stimulates autoubiquitination of recombinant TRAF2 purified from insect cells, free of cIAPs. Reason: Supported by in vitro reconstitution, but follows the same caveats as the E3 activity itself. In cells, TRAF2 is also ubiquitinated by cIAP1, so ubiquitinated TRAF2 alone is not evidence of autoubiquitination. Supporting Evidence: PMID:20577214 S1P also stimulated in vitro autoubiquitination of recombinant TRAF2 (Supplementary Fig. 8d). PMID:11907583 Although c-IAP1 bound TRAF2 and TRAF1 in vitro, it ubiquitinated only TRAF2. |
| GO:0061630 ubiquitin protein ligase activity | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0061630 ubiquitin protein ligase activity | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0061630 ubiquitin protein ligase activity | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: TRAF2 has a RING domain, and recombinant TRAF2 free of cIAPs catalyses K63-linked ubiquitination of RIP1 and itself in vitro, but only in the presence of sphingosine-1-phosphate. PAINT places ubiquitin-protein transferase activity at the vertebrate TRAF2 node (PTN002562154). However, the TRAF2 RING interface is structurally unable to engage Ubc13-type E2s, Sphk1 is dispensable for TRAF2 function in vivo, and the TRAF2 RING is dispensable for MAVS signaling, where its E3 activity is redundant with LUBAC. Reason: The activity is supported by in vitro reconstitution and is accepted by PAINT, so it is not removed. It is non-core: most TRAF2 signaling output can be explained by recruitment of cIAP1/2 and other E3s, and genetic tests show the RING is often dispensable. Cell-based ubiquitination results (GbetaL/MLST8, NLRC5) do not separate TRAF2 catalysis from that of associated cIAPs. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:19810754 These structural differences prevent TRAF2 from interacting with Ubc13 and other related E2s via steric clash and unfavorable interfaces. Our structural observation should prompt a re-evaluation of the role of TRAF2 in TNFalpha signaling and may indicate that TRAF2-associated proteins such as cIAPs may be the ubiquitin ligases for NF-kappaB signaling. PMID:23951545 whereas the E3 ligase activity of TRAF2 is redundant with that of LUBAC in the Traf2-dependent pathway downstream of MAVS PMID:26701909 Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-ΞΊB and MAP kinase signalling |
| GO:0065003 protein-containing complex assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: TRAF2 domains drive assembly of receptor signaling complexes. Reason: True (TRAF2 trimers scaffold receptor-cIAP-kinase assemblies), but general; kept as non-core rather than replaced, because no single specific assembly term covers the range of complexes. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0065003 protein-containing complex assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: TRAF2 domains drive assembly of receptor signaling complexes. Reason: True (TRAF2 trimers scaffold receptor-cIAP-kinase assemblies), but general; kept as non-core rather than replaced, because no single specific assembly term covers the range of complexes. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0065003 protein-containing complex assembly | TAS PMID:8702708 Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB... | KEEP AS NON CORE | Summary: TRAF2 domains drive assembly of receptor signaling complexes. Reason: True (TRAF2 trimers scaffold receptor-cIAP-kinase assemblies), but general; kept as non-core rather than replaced, because no single specific assembly term covers the range of complexes. Supporting Evidence: PMID:20447407 To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | TAS PMID:14685163 Roles of CHOP/GADD153 in endoplasmic reticulum stress. | KEEP AS NON CORE | Summary: Under severe ER stress, IRE1-TRAF2-ASK1 complexes drive pro-apoptotic JNK signaling. Reason: TRAF2 is the adaptor in this branch; a stimulus-specific role. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | TAS PMID:22013210 The unfolded protein response: integrating stress signals th... | KEEP AS NON CORE | Summary: Under severe ER stress, IRE1-TRAF2-ASK1 complexes drive pro-apoptotic JNK signaling. Reason: TRAF2 is the adaptor in this branch; a stimulus-specific role. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:15258597 De-ubiquitination and ubiquitin ligase domains of A20 downre... | ACCEPT | Summary: TRAF2 drives K63-linked ubiquitination of RIP1, GbetaL/MLST8 and other targets, either by recruiting cIAP1/2 or, in reconstituted S1P-containing reactions, directly. Reason: TRAF2 does work in this process as the scaffold that brings E3s and substrates together, and possibly as a cofactor-dependent E3; either way the process annotation holds. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:20577214 Sphingosine-1-phosphate is a missing cofactor for the E3 ubi... | ACCEPT | Summary: TRAF2 drives K63-linked ubiquitination of RIP1, GbetaL/MLST8 and other targets, either by recruiting cIAP1/2 or, in reconstituted S1P-containing reactions, directly. Reason: TRAF2 does work in this process as the scaffold that brings E3s and substrates together, and possibly as a cofactor-dependent E3; either way the process annotation holds. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:0070534 protein K63-linked ubiquitination | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | ACCEPT | Summary: TRAF2 drives K63-linked ubiquitination of RIP1, GbetaL/MLST8 and other targets, either by recruiting cIAP1/2 or, in reconstituted S1P-containing reactions, directly. Reason: TRAF2 does work in this process as the scaffold that brings E3s and substrates together, and possibly as a cofactor-dependent E3; either way the process annotation holds. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:0070534 protein K63-linked ubiquitination | IEA GO_REF:0000120 | ACCEPT | Summary: TRAF2 drives K63-linked ubiquitination of RIP1, GbetaL/MLST8 and other targets, either by recruiting cIAP1/2 or, in reconstituted S1P-containing reactions, directly. Reason: TRAF2 does work in this process as the scaffold that brings E3s and substrates together, and possibly as a cofactor-dependent E3; either way the process annotation holds. Supporting Evidence: PMID:20577214 In agreement with previous studies 20,21, incubation of purified RIP1 with recombinant TRAF2, ubiquitin, the ubiquitin-activating enzyme E1, and Ubc13/Uev1a, an E2 that facilitates Lys 63 polyubiquitination, failed to produce ubiquitinated RIP1. Remarkably however, addition of S1P induced efficient TRAF2-mediated ubiquitination of RIP1 (Fig. 3a). PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:0097057 TRAF2-GSTP1 complex | IDA PMID:16636664 Human glutathione S-transferase P1-1 interacts with TRAF2 an... | KEEP AS NON CORE | Summary: GSTP1 associates with TRAF2 in vivo and in vitro. Reason: Directly supported but a regulatory complex peripheral to TRAF2's main role. Supporting Evidence: PMID:16636664 The present experiments showed that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro. |
| GO:0097400 interleukin-17-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Projected from mouse Traf2 (same PANTHER subfamily), where TRAF2/TRAF5 act with Act1 in IL-17 receptor signaling, including stabilization of chemokine mRNAs. Reason: Orthology transfer within PTHR10131:SF21 is sound, and the mouse role fits TRAF2's general adaptor function; a receptor-specific context, kept as non-core. |
| GO:0140639 positive regulation of pyroptotic inflammatory response | IDA PMID:40097387 Ubiquitination of gasdermin D N-terminal domain directs its ... | KEEP AS NON CORE | Summary: TRAF2 coexpression enhances GSDMD-NT ubiquitination and restores pyroptosis by a tagged GSDMD-NT. Reason: Experimental, but overexpression-based and indirect (no direct TRAF2-GSDMD-NT binding); non-core. Supporting Evidence: PMID:40097387 Moreover, we found that 3βΓβFlag-GD-NT, which loses its pore-forming activity due to the addition of triple Flag-tag on its N-terminal [3], regained the ability to mediate pyroptosis with the assistance of TRAF1 and TRAF2 (Fig. 2IβK). |
| GO:0160162 CD27 signaling pathway | IDA PMID:38354704 Signaling via a CD27-TRAF2-SHP-1 axis during naive TΒ cell ac... | ACCEPT | Summary: CD27 recruits TRAF2 as its signaling adaptor. Reason: TRAF2 does the adaptor work in this TNFR-superfamily pathway, as it does for CD40 and TNFR2. Supporting Evidence: PMID:38354704 Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. |
| GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Projected from mouse Traf2. Reason: TRAF2 is part of TNF signaling rather than an external regulator of it; core participation is captured by GO:0033209. The regulatory term is kept as non-core. |
| GO:1905669 TORC1 complex assembly | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | KEEP AS NON CORE | Summary: TRAF2-promoted K63 ubiquitination of GbetaL/MLST8 disrupts its binding to SIN1, favouring mTORC1 over mTORC2 assembly. Reason: Experimentally supported, but the same study concludes that OTUD7B deubiquitination, rather than TRAF2, is the step regulated by growth signals; a non-core role. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905669 TORC1 complex assembly | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: TRAF2-promoted K63 ubiquitination of GbetaL/MLST8 disrupts its binding to SIN1, favouring mTORC1 over mTORC2 assembly. Reason: Experimentally supported, but the same study concludes that OTUD7B deubiquitination, rather than TRAF2, is the step regulated by growth signals; a non-core role. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905670 TORC2 complex disassembly | IDA PMID:28489822 TRAF2 and OTUD7B govern a ubiquitin-dependent switch that re... | KEEP AS NON CORE | Summary: TRAF2-promoted K63 ubiquitination of GbetaL/MLST8 disrupts its binding to SIN1, favouring mTORC1 over mTORC2 assembly. Reason: Experimentally supported, but the same study concludes that OTUD7B deubiquitination, rather than TRAF2, is the step regulated by growth signals; a non-core role. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1905670 TORC2 complex disassembly | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: TRAF2-promoted K63 ubiquitination of GbetaL/MLST8 disrupts its binding to SIN1, favouring mTORC1 over mTORC2 assembly. Reason: Experimentally supported, but the same study concludes that OTUD7B deubiquitination, rather than TRAF2, is the step regulated by growth signals; a non-core role. Supporting Evidence: PMID:28489822 Mechanistically, the TRAF2 E3 ubiquitin ligase promotes K63-linked polyubiquitination of GΞ²L, which disrupts its interaction with the unique mTORC2 component SIN1 (refs 12, 13, 14) to favour mTORC1 formation. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IBA GO_REF:0000033 | ACCEPT | Summary: IRE1-TRAF2-ASK1 complexes form during ER stress; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Directly shown in human cells and supported by the phylogenetic inference. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IDA PMID:23000344 Ursolic acid induces ER stress response to activate ASK1-JNK... | ACCEPT | Summary: IRE1-TRAF2-ASK1 complexes form during ER stress; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Directly shown in human cells and supported by the phylogenetic inference. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:1990604 IRE1-TRAF2-ASK1 complex | IEA GO_REF:0000120 | ACCEPT | Summary: IRE1-TRAF2-ASK1 complexes form during ER stress; PAINT places this at the vertebrate TRAF2 node PTN002562154. Reason: Directly shown in human cells and supported by the phylogenetic inference. Supporting Evidence: PMID:23000344 Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling. PMID:10650002 The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. |
| GO:2001238 positive regulation of extrinsic apoptotic signaling pathway | IMP PMID:21525013 TWEAK induces apoptosis through a death-signaling complex co... | UNDECIDED | Summary: IMP from a TWEAK study in which FN14 recruits TRAF2 and cIAP1 and TWEAK drives apoptosis through autocrine TNF. Reason: The abstract shows TRAF2 in the FN14 complex but does not report the TRAF2 loss-of-function result behind this IMP; the full text was not available. Supporting Evidence: PMID:21525013 TWEAK assembled a proximal signaling complex containing its cognate receptor FN14, the adaptor TRAF2, and cellular inhibitor of apoptosis protein 1 (cIAP1). |
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Download this section (compressed HTML)Q: Under which receptor and cell contexts is TRAF2 RING-dependent ubiquitin ligase activity required in vivo, given that the RING is dispensable for MAVS signaling and Sphk1 is dispensable for TRAF2 function?
Q: Does any E2 other than the Ubc13/UbcH5 family productively engage the atypical TRAF2 RING, and is sphingosine-1-phosphate a physiological cofactor?
Experiment: Knock-in of a catalytically inactive TRAF2 RING mutant (with the cIAP-binding coiled coil intact) in mouse, comparing TNFR1, CD40 and IL-17R signaling with Traf2-null and cIAP1/2-deficient cells.
Experiment: Defined in vitro reconstitution of TRAF2 with a panel of E2s, with and without S1P, using cIAP-free TRAF2 from several expression systems and RING point mutants as controls.
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