ID TPC13_HUMAN Reviewed; 417 AA. AC A5PLN9; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 26-FEB-2008, sequence version 2. DT 28-JAN-2026, entry version 130. DE RecName: Full=Trafficking protein particle complex subunit 13; GN Name=TRAPPC13; Synonyms=C5orf44; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 211-417 (ISOFORM 1). RC TISSUE=Brain, and Small intestine; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 12-417 (ISOFORM 2). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-417 (ISOFORM 4). RA Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., RA Wen S., Lin L., Yang S.; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP IDENTIFICATION IN TRAPP COMPLEX. RX PubMed=21453443; DOI=10.1111/j.1600-0854.2011.01181.x; RA Choi C., Davey M., Schluter C., Pandher P., Fang Y., Foster L.J., RA Conibear E.; RT "Organization and assembly of the TRAPPII complex."; RL Traffic 12:715-725(2011). CC -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle) CC complex. {ECO:0000269|PubMed:21453443}. CC -!- INTERACTION: CC A5PLN9; Q9UL33: TRAPPC2L; NbExp=3; IntAct=EBI-2857298, EBI-747601; CC A5PLN9; O43617: TRAPPC3; NbExp=2; IntAct=EBI-2857298, EBI-743566; CC A5PLN9; Q9Y2L5: TRAPPC8; NbExp=2; IntAct=EBI-2857298, EBI-2820056; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=A5PLN9-1; Sequence=Displayed; CC Name=2; CC IsoId=A5PLN9-2; Sequence=VSP_038356; CC Name=3; CC IsoId=A5PLN9-4; Sequence=VSP_038356, VSP_038359; CC Name=4; CC IsoId=A5PLN9-5; Sequence=VSP_038359; CC Name=5; CC IsoId=A5PLN9-7; Sequence=VSP_038356, VSP_038357, VSP_038358; CC -!- MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA CC decay. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the TRAPPC13 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH47475.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; CC Sequence=BAB14633.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL713699; CAD28498.1; -; mRNA. DR EMBL; BX641157; CAE46070.1; -; mRNA. DR EMBL; AK023673; BAB14633.1; ALT_SEQ; mRNA. DR EMBL; AC008560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471137; EAW51346.1; -; Genomic_DNA. DR EMBL; BC047475; AAH47475.1; ALT_SEQ; mRNA. DR EMBL; BC117128; AAI17129.1; -; mRNA. DR EMBL; BC142994; AAI42995.1; -; mRNA. DR EMBL; DQ088673; AAY88966.1; -; mRNA. DR CCDS; CCDS47221.1; -. [A5PLN9-5] DR CCDS; CCDS47222.1; -. [A5PLN9-1] DR CCDS; CCDS47223.1; -. [A5PLN9-2] DR CCDS; CCDS58950.1; -. [A5PLN9-4] DR RefSeq; NP_001087224.1; NM_001093755.2. [A5PLN9-5] DR RefSeq; NP_001087225.1; NM_001093756.2. [A5PLN9-2] DR RefSeq; NP_001230666.1; NM_001243737.2. [A5PLN9-4] DR RefSeq; NP_079217.2; NM_024941.4. [A5PLN9-1] DR AlphaFoldDB; A5PLN9; -. DR BioGRID; 123063; 98. DR ComplexPortal; CPX-4749; TRAPP II complex, TRAPPC2 variant. DR ComplexPortal; CPX-6902; TRAPP II complex, TRAPPC2B variant. DR CORUM; A5PLN9; -. DR DIP; DIP-48284N; -. DR FunCoup; A5PLN9; 2141. DR IntAct; A5PLN9; 37. DR MINT; A5PLN9; -. DR STRING; 9606.ENSP00000409231; -. DR GlyGen; A5PLN9; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; A5PLN9; -. DR PhosphoSitePlus; A5PLN9; -. DR BioMuta; TRAPPC13; -. DR jPOST; A5PLN9; -. DR MassIVE; A5PLN9; -. DR PaxDb; 9606-ENSP00000409231; -. DR PeptideAtlas; A5PLN9; -. DR ProteomicsDB; 744; -. [A5PLN9-1] DR ProteomicsDB; 745; -. [A5PLN9-2] DR ProteomicsDB; 746; -. [A5PLN9-4] DR ProteomicsDB; 747; -. [A5PLN9-5] DR ProteomicsDB; 748; -. [A5PLN9-7] DR Pumba; A5PLN9; -. DR Antibodypedia; 43978; 44 antibodies from 16 providers. DR DNASU; 80006; -. DR Ensembl; ENST00000231526.8; ENSP00000231526.4; ENSG00000113597.19. [A5PLN9-2] DR Ensembl; ENST00000399438.8; ENSP00000382367.3; ENSG00000113597.19. [A5PLN9-1] DR Ensembl; ENST00000438419.6; ENSP00000409231.2; ENSG00000113597.19. [A5PLN9-5] DR Ensembl; ENST00000505553.5; ENSP00000423405.1; ENSG00000113597.19. [A5PLN9-4] DR Ensembl; ENST00000715762.1; ENSP00000520517.1; ENSG00000113597.19. [A5PLN9-1] DR GeneID; 80006; -. DR KEGG; hsa:80006; -. DR MANE-Select; ENST00000399438.8; ENSP00000382367.3; NM_024941.4; NP_079217.2. DR UCSC; uc003jtz.5; human. [A5PLN9-1] DR AGR; HGNC:25828; -. DR ClinPGx; PA162380280; -. DR CTD; 80006; -. DR GeneCards; TRAPPC13; -. DR HGNC; HGNC:25828; TRAPPC13. DR HPA; ENSG00000113597; Low tissue specificity. DR OpenTargets; ENSG00000113597; -. DR VEuPathDB; HostDB:ENSG00000113597; -. DR eggNOG; KOG2625; Eukaryota. DR GeneTree; ENSGT00390000015280; -. DR HOGENOM; CLU_027041_0_0_1; -. DR InParanoid; A5PLN9; -. DR OMA; YLCVHNG; -. DR OrthoDB; 10250284at2759; -. DR PAN-GO; A5PLN9; 1 GO annotation based on evolutionary models. DR PhylomeDB; A5PLN9; -. DR PathwayCommons; A5PLN9; -. DR Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs. DR SignaLink; A5PLN9; -. DR Agora; ENSG00000113597; -. DR BioGRID-ORCS; 80006; 174 hits in 1163 CRISPR screens. DR ChiTaRS; TRAPPC13; human. DR GenomeRNAi; 80006; -. DR Pharos; A5PLN9; Tdark. DR PRO; PR:A5PLN9; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; A5PLN9; protein. DR Bgee; ENSG00000113597; Expressed in buccal mucosa cell and 187 other cell types or tissues. DR ExpressionAtlas; A5PLN9; baseline and differential. DR GO; GO:0005737; C:cytoplasm; NAS:ComplexPortal. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:1990071; C:TRAPPII protein complex; NAS:ComplexPortal. DR GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central. DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; NAS:ComplexPortal. DR GO; GO:0006901; P:vesicle coating; NAS:ComplexPortal. DR GO; GO:0099022; P:vesicle tethering; NAS:ComplexPortal. DR InterPro; IPR010378; TRAPPC13. DR InterPro; IPR055428; TRAPPC13_C. DR InterPro; IPR055429; TRAPPC13_M. DR InterPro; IPR055427; TRAPPC13_N. DR PANTHER; PTHR13134; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13; 1. DR PANTHER; PTHR13134:SF3; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13; 1. DR Pfam; PF23643; TRAPPC13_C; 1. DR Pfam; PF23647; TRAPPC13_M; 1. DR Pfam; PF06159; TRAPPC13_N; 1. PE 1: Evidence at protein level; KW Alternative splicing; Proteomics identification; Reference proteome. FT CHAIN 1..417 FT /note="Trafficking protein particle complex subunit 13" FT /id="PRO_0000321547" FT VAR_SEQ 183..188 FT /note="Missing (in isoform 2, isoform 3 and isoform 5)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_038356" FT VAR_SEQ 300..315 FT /note="APGYGDVRLSLEAIPD -> VSLEKTSLGFWCVKDR (in isoform 5)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_038357" FT VAR_SEQ 316..417 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_038358" FT VAR_SEQ 332 FT /note="C -> CS (in isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6" FT /id="VSP_038359" FT CONFLICT 177 FT /note="K -> R (in Ref. 6; AAY88966)" FT /evidence="ECO:0000305" FT CONFLICT 255 FT /note="L -> P (in Ref. 6; AAY88966)" FT /evidence="ECO:0000305" FT CONFLICT 403 FT /note="I -> V (in Ref. 5; AAI42995)" FT /evidence="ECO:0000305" SQ SEQUENCE 417 AA; 46524 MW; 7E80D7B11511DC6E CRC64; MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH WCGISGRQLG KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY DDIAQVCVVS SAIKVES //