ID   TPPC4_HUMAN             Reviewed;         219 AA.
AC   Q9Y296; A8K3A5; B4DME1;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   28-JAN-2026, entry version 196.
DE   RecName: Full=Trafficking protein particle complex subunit 4 {ECO:0000305};
DE   AltName: Full=Hematopoietic stem/progenitor cell protein 172;
DE   AltName: Full=Synbindin {ECO:0000250|UniProtKB:Q9ES56};
DE   AltName: Full=TRS23 homolog;
GN   Name=TRAPPC4 {ECO:0000312|HGNC:HGNC:19943};
GN   Synonyms=SBDN {ECO:0000250|UniProtKB:Q9ES56};
GN   ORFNames=CGI-104, HSPC172, PTD009;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Zhu X., Zhao X.;
RT   "Human unknown mRNA highly conserved among eukaryotes.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Pituitary tumor;
RA   Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G.,
RA   Luo M., Chen J., Hu R.;
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Umbilical cord blood;
RX   PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for 300
RT   previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT   cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA   Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT   "Identification of novel human genes evolutionarily conserved in
RT   Caenorhabditis elegans by comparative proteomics.";
RL   Genome Res. 10:703-713(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   IDENTIFICATION IN TRAPP COMPLEX.
RX   PubMed=11805826; DOI=10.1038/415141a;
RA   Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A.,
RA   Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C.,
RA   Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M.,
RA   Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C.,
RA   Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V.,
RA   Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B.,
RA   Neubauer G., Superti-Furga G.;
RT   "Functional organization of the yeast proteome by systematic analysis of
RT   protein complexes.";
RL   Nature 415:141-147(2002).
RN   [10]
RP   IDENTIFICATION IN TRAPP COMPLEX, AND INTERACTION WITH TRAPPC2L.
RX   PubMed=19416478; DOI=10.1111/j.1600-0854.2009.00906.x;
RA   Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.;
RT   "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein.";
RL   Traffic 10:724-736(2009).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [12]
RP   IDENTIFICATION IN TRAPP COMPLEX.
RX   PubMed=21525244; DOI=10.1091/mbc.e10-11-0873;
RA   Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.;
RT   "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early
RT   stage in ER-to-Golgi trafficking.";
RL   Mol. Biol. Cell 22:2083-2093(2011).
RN   [13]
RP   INVOLVEMENT IN NEDESBA, FUNCTION, AND IDENTIFICATION IN TRAPP COMPLEX.
RX   PubMed=31794024; DOI=10.1093/brain/awz374;
RA   Van Bergen N.J., Guo Y., Al-Deri N., Lipatova Z., Stanga D., Zhao S.,
RA   Murtazina R., Gyurkovska V., Pehlivan D., Mitani T., Gezdirici A.,
RA   Antony J., Collins F., Willis M.J.H., Coban Akdemir Z.H., Liu P.,
RA   Punetha J., Hunter J.V., Jhangiani S.N., Fatih J.M., Rosenfeld J.A.,
RA   Posey J.E., Gibbs R.A., Karaca E., Massey S., Ranasinghe T.G., Sleiman P.,
RA   Troedson C., Lupski J.R., Sacher M., Segev N., Hakonarson H.,
RA   Christodoulou J.;
RT   "Deficiencies in vesicular transport mediated by TRAPPC4 are associated
RT   with severe syndromic intellectual disability.";
RL   Brain 143:112-130(2020).
CC   -!- FUNCTION: Core component of the TRAPP complexes which has a function of
CC       guanine nucleotide exchange factor activity for Rab1 GTPase (Probable).
CC       Plays a role in vesicular transport from endoplasmic reticulum to Golgi
CC       and autophagy (PubMed:31794024). May play a role in dendrite
CC       postsynaptic membrane trafficking (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ES56, ECO:0000269|PubMed:31794024,
CC       ECO:0000305|PubMed:31794024}.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12 (Probable). Interacts with SDC2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ES56, ECO:0000305|PubMed:31794024}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9ES56}. Vesicle {ECO:0000250|UniProtKB:Q9ES56}.
CC       Note=Associated with postsynaptic membranes and in intracellular
CC       cisterns and vesicles (Golgi). {ECO:0000250|UniProtKB:Q9ES56}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y296-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y296-2; Sequence=VSP_056348;
CC   -!- DISEASE: Neurodevelopmental disorder with epilepsy, spasticity, and
CC       brain atrophy (NEDESBA) [MIM:618741]: An autosomal recessive disorder
CC       characterized by severely impaired global development apparent soon
CC       after birth, early-onset seizures, lack of psychomotor development,
CC       spastic quadriparesis, progressive cortical and cerebellar atrophy, and
CC       dysmorphic features, including microcephaly. Death in childhood may
CC       occur. {ECO:0000269|PubMed:31794024}. Note=The disease is caused by
CC       variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. TRAPPC4
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF105025; AAF21897.1; -; mRNA.
DR   EMBL; AF078862; AAD44494.1; -; mRNA.
DR   EMBL; AF161520; AAF29135.1; -; mRNA.
DR   EMBL; AF151862; AAD34099.1; -; mRNA.
DR   EMBL; AK290520; BAF83209.1; -; mRNA.
DR   EMBL; AK297422; BAG59853.1; -; mRNA.
DR   EMBL; AP003392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67430.1; -; Genomic_DNA.
DR   EMBL; BC010866; AAH10866.1; -; mRNA.
DR   CCDS; CCDS81633.1; -. [Q9Y296-2]
DR   CCDS; CCDS8407.1; -. [Q9Y296-1]
DR   RefSeq; NP_001305415.1; NM_001318486.1.
DR   RefSeq; NP_001305417.1; NM_001318488.1.
DR   RefSeq; NP_001305418.1; NM_001318489.2. [Q9Y296-2]
DR   RefSeq; NP_001305419.1; NM_001318490.1.
DR   RefSeq; NP_001305421.1; NM_001318492.1.
DR   RefSeq; NP_001305423.1; NM_001318494.1.
DR   RefSeq; NP_057230.1; NM_016146.6. [Q9Y296-1]
DR   PDB; 2J3T; X-ray; 2.40 A; D=1-219.
DR   PDB; 2JSN; NMR; -; A=19-106.
DR   PDB; 2ZMV; X-ray; 2.80 A; A/B=1-219.
DR   PDBsum; 2J3T; -.
DR   PDBsum; 2JSN; -.
DR   PDBsum; 2ZMV; -.
DR   AlphaFoldDB; Q9Y296; -.
DR   BMRB; Q9Y296; -.
DR   SMR; Q9Y296; -.
DR   BioGRID; 119523; 85.
DR   ComplexPortal; CPX-4749; TRAPP II complex, TRAPPC2 variant.
DR   ComplexPortal; CPX-4750; TRAPP III complex, TRAPPC2 variant.
DR   ComplexPortal; CPX-6902; TRAPP II complex, TRAPPC2B variant.
DR   ComplexPortal; CPX-6903; TRAPP III complex, TRAPPC2B variant.
DR   CORUM; Q9Y296; -.
DR   DIP; DIP-37871N; -.
DR   FunCoup; Q9Y296; 1110.
DR   STRING; 9606.ENSP00000436005; -.
DR   DrugBank; DB08342; S-palmitoyl-L-cysteine.
DR   iPTMnet; Q9Y296; -.
DR   PhosphoSitePlus; Q9Y296; -.
DR   BioMuta; TRAPPC4; -.
DR   DMDM; 20178121; -.
DR   jPOST; Q9Y296; -.
DR   MassIVE; Q9Y296; -.
DR   PaxDb; 9606-ENSP00000436005; -.
DR   PeptideAtlas; Q9Y296; -.
DR   ProteomicsDB; 4601; -.
DR   ProteomicsDB; 85704; -. [Q9Y296-1]
DR   Pumba; Q9Y296; -.
DR   Antibodypedia; 32564; 311 antibodies from 26 providers.
DR   DNASU; 51399; -.
DR   Ensembl; ENST00000434101.6; ENSP00000405033.2; ENSG00000196655.13. [Q9Y296-2]
DR   Ensembl; ENST00000533632.6; ENSP00000436005.1; ENSG00000196655.13. [Q9Y296-1]
DR   Ensembl; ENST00000629243.3; ENSP00000487467.1; ENSG00000280495.5. [Q9Y296-1]
DR   Ensembl; ENST00000629713.2; ENSP00000486496.1; ENSG00000280495.5. [Q9Y296-2]
DR   GeneID; 51399; -.
DR   KEGG; hsa:51399; -.
DR   MANE-Select; ENST00000533632.6; ENSP00000436005.1; NM_016146.6; NP_057230.1.
DR   UCSC; uc010ryo.4; human. [Q9Y296-1]
DR   AGR; HGNC:19943; -.
DR   ClinPGx; PA134906910; -.
DR   CTD; 51399; -.
DR   DisGeNET; 51399; -.
DR   GeneCards; TRAPPC4; -.
DR   HGNC; HGNC:19943; TRAPPC4.
DR   HPA; ENSG00000196655; Low tissue specificity.
DR   MalaCards; TRAPPC4; -.
DR   MIM; 610971; gene.
DR   MIM; 618741; phenotype.
DR   OpenTargets; ENSG00000196655; -.
DR   Orphanet; 528084; Non-specific syndromic intellectual disability.
DR   VEuPathDB; HostDB:ENSG00000196655; -.
DR   eggNOG; KOG3369; Eukaryota.
DR   GeneTree; ENSGT00940000153761; -.
DR   InParanoid; Q9Y296; -.
DR   OMA; GQRDGIN; -.
DR   OrthoDB; 246406at2759; -.
DR   PAN-GO; Q9Y296; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; Q9Y296; -.
DR   PathwayCommons; Q9Y296; -.
DR   Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-HSA-3000170; Syndecan interactions.
DR   Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   SignaLink; Q9Y296; -.
DR   Agora; ENSG00000196655; -.
DR   BioGRID-ORCS; 51399; 503 hits in 1161 CRISPR screens.
DR   ChiTaRS; TRAPPC4; human.
DR   EvolutionaryTrace; Q9Y296; -.
DR   GeneWiki; TRAPPC4; -.
DR   GenomeRNAi; 51399; -.
DR   Pharos; Q9Y296; Tbio.
DR   PRO; PR:Q9Y296; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9Y296; protein.
DR   Bgee; ENSG00000196655; Expressed in cortical plate and 101 other cell types or tissues.
DR   ExpressionAtlas; Q9Y296; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; NAS:ComplexPortal.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005795; C:Golgi stack; ISS:UniProtKB.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR   GO; GO:0048786; C:presynaptic active zone; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0030008; C:TRAPP complex; IDA:UniProtKB.
DR   GO; GO:1990071; C:TRAPPII protein complex; NAS:ComplexPortal.
DR   GO; GO:1990072; C:TRAPPIII protein complex; NAS:ComplexPortal.
DR   GO; GO:0006914; P:autophagy; IMP:UniProtKB.
DR   GO; GO:0048208; P:COPII vesicle coating; NAS:ComplexPortal.
DR   GO; GO:0016358; P:dendrite development; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IMP:UniProtKB.
DR   GO; GO:0006901; P:vesicle coating; NAS:ComplexPortal.
DR   GO; GO:0099022; P:vesicle tethering; NAS:ComplexPortal.
DR   CDD; cd14856; TRAPPC4_synbindin; 1.
DR   DisProt; DP00562; -.
DR   FunFam; 3.30.450.70:FF:000002; Trafficking protein particle complex subunit 4; 1.
DR   Gene3D; 3.30.450.70; -; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR007233; TRAPPC.
DR   PANTHER; PTHR23249; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT; 1.
DR   PANTHER; PTHR23249:SF15; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF04099; Sybindin; 1.
DR   SMART; SM01399; Sybindin; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell membrane; Endoplasmic reticulum;
KW   ER-Golgi transport; Golgi apparatus; Membrane; Postsynaptic cell membrane;
KW   Proteomics identification; Reference proteome; Synapse; Transport.
FT   CHAIN           1..219
FT                   /note="Trafficking protein particle complex subunit 4"
FT                   /id="PRO_0000211569"
FT   VAR_SEQ         81..134
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056348"
FT   VARIANT         78
FT                   /note="D -> A (in dbSNP:rs11640)"
FT                   /id="VAR_052397"
FT   STRAND          3..9
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          15..20
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          28..32
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          37..42
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          44..51
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          54..56
FT                   /evidence="ECO:0007829|PDB:2JSN"
FT   TURN            57..60
FT                   /evidence="ECO:0007829|PDB:2JSN"
FT   STRAND          62..66
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          79..81
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   HELIX           82..85
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   HELIX           89..91
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          93..99
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   HELIX           105..124
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          127..130
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          135..141
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          143..148
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   STRAND          154..159
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   HELIX           166..181
FT                   /evidence="ECO:0007829|PDB:2J3T"
FT   HELIX           196..209
FT                   /evidence="ECO:0007829|PDB:2J3T"
SQ   SEQUENCE   219 AA;  24340 MW;  C6ADE525B7CFB731 CRC64;
     MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG
     HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA
     IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF
     ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS
//