ID   TPPC5_HUMAN             Reviewed;         188 AA.
AC   Q8IUR0; A8K7I6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   28-JAN-2026, entry version 161.
DE   RecName: Full=Trafficking protein particle complex subunit 5;
GN   Name=TRAPPC5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5]
RP   IDENTIFICATION IN TRAPP COMPLEX.
RX   PubMed=21525244; DOI=10.1091/mbc.e10-11-0873;
RA   Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.;
RT   "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early
RT   stage in ER-to-Golgi trafficking.";
RL   Mol. Biol. Cell 22:2083-2093(2011).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12. {ECO:0000269|PubMed:21525244}.
CC   -!- INTERACTION:
CC       Q8IUR0; O95273: CCNDBP1; NbExp=8; IntAct=EBI-3246160, EBI-748961;
CC       Q8IUR0; Q9NP66: HMG20A; NbExp=5; IntAct=EBI-3246160, EBI-740641;
CC       Q8IUR0; P0DI81-3: TRAPPC2; NbExp=5; IntAct=EBI-3246160, EBI-11961968;
CC       Q8IUR0; O43617: TRAPPC3; NbExp=9; IntAct=EBI-3246160, EBI-743566;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AK292001; BAF84690.1; -; mRNA.
DR   EMBL; CH471139; EAW69012.1; -; Genomic_DNA.
DR   EMBL; BC042161; AAH42161.1; -; mRNA.
DR   CCDS; CCDS42490.1; -.
DR   RefSeq; NP_001035926.1; NM_001042461.3.
DR   RefSeq; NP_001035927.1; NM_001042462.2.
DR   RefSeq; NP_777554.1; NM_174894.3.
DR   AlphaFoldDB; Q8IUR0; -.
DR   SMR; Q8IUR0; -.
DR   BioGRID; 125945; 144.
DR   ComplexPortal; CPX-4749; TRAPP II complex, TRAPPC2 variant.
DR   ComplexPortal; CPX-4750; TRAPP III complex, TRAPPC2 variant.
DR   ComplexPortal; CPX-6902; TRAPP II complex, TRAPPC2B variant.
DR   ComplexPortal; CPX-6903; TRAPP III complex, TRAPPC2B variant.
DR   CORUM; Q8IUR0; -.
DR   FunCoup; Q8IUR0; 1222.
DR   IntAct; Q8IUR0; 82.
DR   MINT; Q8IUR0; -.
DR   STRING; 9606.ENSP00000470262; -.
DR   ChEMBL; CHEMBL4295892; -.
DR   DrugBank; DB08342; S-palmitoyl-L-cysteine.
DR   iPTMnet; Q8IUR0; -.
DR   PhosphoSitePlus; Q8IUR0; -.
DR   BioMuta; TRAPPC5; -.
DR   DMDM; 71153352; -.
DR   jPOST; Q8IUR0; -.
DR   MassIVE; Q8IUR0; -.
DR   PaxDb; 9606-ENSP00000470262; -.
DR   PeptideAtlas; Q8IUR0; -.
DR   ProteomicsDB; 70597; -.
DR   Pumba; Q8IUR0; -.
DR   Antibodypedia; 24583; 98 antibodies from 24 providers.
DR   DNASU; 126003; -.
DR   Ensembl; ENST00000317378.5; ENSP00000316990.4; ENSG00000181029.10.
DR   Ensembl; ENST00000426877.2; ENSP00000399025.1; ENSG00000181029.10.
DR   Ensembl; ENST00000596148.3; ENSP00000470262.1; ENSG00000181029.10.
DR   GeneID; 126003; -.
DR   KEGG; hsa:126003; -.
DR   MANE-Select; ENST00000596148.3; ENSP00000470262.1; NM_001042462.2; NP_001035927.1.
DR   UCSC; uc002mhi.2; human.
DR   AGR; HGNC:23067; -.
DR   ClinPGx; PA134875218; -.
DR   CTD; 126003; -.
DR   DisGeNET; 126003; -.
DR   GeneCards; TRAPPC5; -.
DR   HGNC; HGNC:23067; TRAPPC5.
DR   HPA; ENSG00000181029; Low tissue specificity.
DR   OpenTargets; ENSG00000181029; -.
DR   VEuPathDB; HostDB:ENSG00000181029; -.
DR   eggNOG; KOG3315; Eukaryota.
DR   GeneTree; ENSGT00390000000976; -.
DR   HOGENOM; CLU_073154_2_0_1; -.
DR   InParanoid; Q8IUR0; -.
DR   OMA; YMVKFDD; -.
DR   OrthoDB; 10254842at2759; -.
DR   PAN-GO; Q8IUR0; 4 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8IUR0; -.
DR   PathwayCommons; Q8IUR0; -.
DR   Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   SignaLink; Q8IUR0; -.
DR   Agora; ENSG00000181029; -.
DR   BioGRID-ORCS; 126003; 703 hits in 1088 CRISPR screens.
DR   ChiTaRS; TRAPPC5; human.
DR   GenomeRNAi; 126003; -.
DR   Pharos; Q8IUR0; Tdark.
DR   PRO; PR:Q8IUR0; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8IUR0; protein.
DR   Bgee; ENSG00000181029; Expressed in left testis and 97 other cell types or tissues.
DR   ExpressionAtlas; Q8IUR0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; NAS:ComplexPortal.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IDA:UniProtKB.
DR   GO; GO:1990070; C:TRAPPI protein complex; IBA:GO_Central.
DR   GO; GO:1990071; C:TRAPPII protein complex; IBA:GO_Central.
DR   GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central.
DR   GO; GO:0048208; P:COPII vesicle coating; NAS:ComplexPortal.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006901; P:vesicle coating; NAS:ComplexPortal.
DR   GO; GO:0099022; P:vesicle tethering; NAS:ComplexPortal.
DR   CDD; cd14943; TRAPPC5_Trs31; 1.
DR   FunFam; 3.30.1380.20:FF:000005; Trafficking protein particle complex subunit 5; 1.
DR   Gene3D; 3.30.1380.20; Trafficking protein particle complex subunit 3; 1.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR016696; TRAPP-I_su5.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR20902; 41-2 PROTEIN ANTIGEN-RELATED; 1.
DR   PANTHER; PTHR20902:SF0; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF017479; TRAPP_I_complex_Trs31; 1.
DR   SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Phosphoprotein;
KW   Proteomics identification; Reference proteome; Transport.
FT   CHAIN           1..188
FT                   /note="Trafficking protein particle complex subunit 5"
FT                   /id="PRO_0000211579"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         52
FT                   /note="S -> A (in dbSNP:rs6952)"
FT                   /id="VAR_052398"
SQ   SEQUENCE   188 AA;  20783 MW;  BBB876232286CE28 CRC64;
     MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL QSRLAALGRQ
     VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK EADKLEQAND DARTFYIIER
     EPLINTYISV PKENSTLNCA SFTAGIVEAV LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA
     RDRALEGR
//