GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q9C035 TRIM5 is_active_in GO:0005737 cytoplasm cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:106657|MGI:MGI:1337056|MGI:MGI:1338757|MGI:MGI:1913847|MGI:MGI:1914104|MGI:MGI:1923931|MGI:MGI:2137352|MGI:MGI:2137353|MGI:MGI:2137355|MGI:MGI:3612190|MGI:MGI:97904|MGI:MGI:98178|PANTHER:PTN007774218|RGD:1304877|RGD:619964|RGD:708400|UniProtKB:O15553|UniProtKB:O60858|UniProtKB:O75677|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q0PF16|UniProtKB:Q12899|UniProtKB:Q14142|UniProtKB:Q5W0U4|UniProtKB:Q6AZZ1|UniProtKB:Q6P9F5|UniProtKB:Q86WT6|UniProtKB:Q8IWZ4|UniProtKB:Q8IYM9|UniProtKB:Q8WV44|UniProtKB:Q969Q1|UniProtKB:Q96A61|UniProtKB:Q96F44|UniProtKB:Q9BVG3|UniProtKB:Q9BYJ4|UniProtKB:Q9BZY9|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9C035|UniProtKB:Q9C037|UniProtKB:Q9H2S5|UniProtKB:Q9HCM9 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20251220 UniProtKB Q9C035 TRIM5 involved_in GO:0045087 innate immune response biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338757|MGI:MGI:2137355|MGI:MGI:2385051|MGI:MGI:97904|PANTHER:PTN000762195|UniProtKB:O15553|UniProtKB:O60858|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q0PF16|UniProtKB:Q12899|UniProtKB:Q14142|UniProtKB:Q96F44|UniProtKB:Q9BVG3|UniProtKB:Q9BZY9|UniProtKB:Q9C019|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9C035|UniProtKB:Q9UPQ4 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20251220 UniProtKB Q9C035 TRIM5 involved_in GO:0010468 regulation of gene expression biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1859396|MGI:MGI:2137352|MGI:MGI:2137355|MGI:MGI:2684869|MGI:MGI:98178|PANTHER:PTN008394629|UniProtKB:O15553|UniProtKB:P19474|UniProtKB:Q9C030|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20250903 UniProtKB Q9C035 TRIM5 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000318 IBA GO_REF:0000033 MGI:MGI:2137355|MGI:MGI:2385051|MGI:MGI:2447992|MGI:MGI:2684862|MGI:MGI:2684869|MGI:MGI:3612190|PANTHER:PTN007774218|UniProtKB:P14373|UniProtKB:P19474|UniProtKB:Q12899|UniProtKB:Q86WT6|UniProtKB:Q8IWZ4|UniProtKB:Q8IYM9|UniProtKB:Q8WV44|UniProtKB:Q969Q1|UniProtKB:Q96A61|UniProtKB:Q9BVG3|UniProtKB:Q9BYV6|UniProtKB:Q9BZY9|UniProtKB:Q9C029|UniProtKB:Q9C030|UniProtKB:Q9H2S5 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20250903 UniProtKB Q9C035 TRIM5 involved_in GO:0046596 regulation of viral entry into host cell biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:98178|PANTHER:PTN002515827 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20250412 UniProtKB Q9C035 TRIM5 enables GO:0019901 protein kinase binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002515827|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20200205 UniProtKB Q9C035 TRIM5 involved_in GO:0032880 regulation of protein localization biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002515827|UniProtKB:Q0PF16|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20200205 UniProtKB Q9C035 TRIM5 enables GO:0042803 protein homodimerization activity molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002515827|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20200205 UniProtKB Q9C035 TRIM5 involved_in GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002515827|UniProtKB:Q0PF16|UniProtKB:Q9C035 9606 Homo sapiens GO_Central Tripartite motif-containing protein 5 20200205 UniProtKB Q9C035 TRIM5 located_in GO:0005634 nucleus cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 located_in GO:0005737 cytoplasm cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 enables GO:0008270 zinc ion binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000315 9606 Homo sapiens InterPro Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 enables GO:0042802 identical protein binding molecular_function ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027930 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 involved_in GO:0045893 positive regulation of DNA-templated transcription biological_process ECO:0000364 IEA GO_REF:0000108 GO:0003713 9606 Homo sapiens GOC Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 enables GO:0061630 ubiquitin protein ligase activity molecular_function ECO:0000501 IEA GO_REF:0000003 EC:2.3.2.27 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260601 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22493164 UniProtKB:Q13049 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25203322 UniProtKB:O95863 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:26618866 UniProtKB:P13569 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:35156780 UniProtKB:P13569 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:22493164 UniProtKB:Q9C035 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:22829933 UniProtKB:Q9C035 9606 Homo sapiens IntAct Tripartite motif-containing protein 5 20260530 UniProtKB Q9C035 TRIM5 involved_in GO:0140374 antiviral innate immune response biological_process ECO:0000314 IDA PMID:18248090 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260407 UniProtKB Q9C035 TRIM5 located_in GO:0036464 cytoplasmic ribonucleoprotein granule cellular_component ECO:0000314 IDA PMID:20357094 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260309 UniProtKB Q9C035 TRIM5 involved_in GO:0016567 protein ubiquitination biological_process ECO:0007322 IEA GO_REF:0000041 UniPathway:UPA00143 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20260227 UniProtKB Q9C035 TRIM5 located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Tripartite motif-containing protein 5 20251115 UniProtKB Q9C035 TRIM5 located_in GO:0005634 nucleus cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q0PF16 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20240703 UniProtKB Q9C035 TRIM5 enables GO:0003713 transcription coactivator activity molecular_function ECO:0000314 IDA PMID:23077300 9606 Homo sapiens ARUK-UCL Tripartite motif-containing protein 5 20201030 UniProtKB Q9C035 TRIM5 involved_in GO:0044790 suppression of viral release by host biological_process ECO:0000314 IDA PMID:18248090 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20171212 UniProtKB Q9C035 TRIM5 involved_in GO:0046597 host-mediated suppression of symbiont invasion biological_process ECO:0000314 IDA PMID:18248090 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20171212 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q9H492 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150817 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q14457|UniProtKB:Q6ZNE5|UniProtKB:Q9C0C7 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q9BXW4 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q9GZQ8 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:25127057 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 involved_in GO:0006914 autophagy biological_process ECO:0000314 IDA PMID:25127057 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 enables GO:0019901 protein kinase binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:O75385 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 enables GO:0030674 protein-macromolecule adaptor activity molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:O75385|UniProtKB:Q14457 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 involved_in GO:0032880 regulation of protein localization biological_process ECO:0000315 IMP PMID:25127057 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 colocalizes_with GO:1990462 omegasome cellular_component ECO:0000314 IDA PMID:25127057 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150715 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:O95166 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150714 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:P60520 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150714 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q9H0R8 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150714 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25127057 UniProtKB:Q13501 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20150713 UniProtKB Q9C035 TRIM5 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1031716 9606 Homo sapiens Reactome Tripartite motif-containing protein 5 20140925 UniProtKB Q9C035 TRIM5 involved_in GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process ECO:0000314 IDA PMID:23077300 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20131213 UniProtKB Q9C035 TRIM5 located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:18248090 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20131212 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20357094 UniProtKB:Q13501 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121211 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22078707 UniProtKB:P35998 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121211 UniProtKB Q9C035 TRIM5 involved_in GO:0051607 defense response to virus biological_process ECO:0000304 TAS PMID:22291694 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121211 UniProtKB Q9C035 TRIM5 involved_in GO:0002218 activation of innate immune response biological_process ECO:0000314 IDA PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0004842 ubiquitin-protein transferase activity molecular_function ECO:0000314 IDA PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21512573 UniProtKB:O43318 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21512573 UniProtKB:Q8N5C8 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21512573 UniProtKB:Q9NYJ8 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 involved_in GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway biological_process ECO:0000315 IMP PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0038187 pattern recognition receptor activity molecular_function ECO:0000314 IDA PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 involved_in GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process ECO:0000315 IMP PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 involved_in GO:0043410 positive regulation of MAPK cascade biological_process ECO:0000315 IMP PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 involved_in GO:0051607 defense response to virus biological_process ECO:0000304 TAS PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 involved_in GO:0070534 protein K63-linked ubiquitination biological_process ECO:0000314 IDA PMID:21512573 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20121210 UniProtKB Q9C035 TRIM5 enables GO:0042803 protein homodimerization activity molecular_function ECO:0000353 IPI PMID:11331580 UniProtKB:Q9C035 9606 Homo sapiens UniProt Tripartite motif-containing protein 5 20090505