GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB P09936 UCHL1 involved_in GO:0030163 protein catabolic process biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1355274|PANTHER:PTN000063381|RGD:3928|UniProtKB:P15374 9606 Homo sapiens GO_Central Ubiquitin carboxyl-terminal hydrolase isozyme L1 20240820 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000501 IEA GO_REF:0000120 InterPro:IPR001578|InterPro:IPR036959|EC:3.4.19.12 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260428 UniProtKB P09936 UCHL1 located_in GO:0005737 cytoplasm cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260428 UniProtKB P09936 UCHL1 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0097 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260428 UniProtKB P09936 UCHL1 involved_in GO:0006511 ubiquitin-dependent protein catabolic process biological_process ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q00981|ensembl:ENSRNOP00000003248|InterPro:IPR001578|InterPro:IPR036959 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260428 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:12082530 UniProtKB:Q92905 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16049941 UniProtKB:P05067 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16169070 UniProtKB:P83916 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16169070 UniProtKB:Q15843 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19615732 UniProtKB:Q9UK80 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20029029 UniProtKB:P00533 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21044950 UniProtKB:Q9NYB0 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23543736 UniProtKB:P11802 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23543736 UniProtKB:Q00535 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:31980649 UniProtKB:P00533 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:A4FUJ8 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:O15381-5 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:O15392 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:O60739 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:O95777 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P04637 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P05067 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P05067-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P13473-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P18847 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P19474 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P61086 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P62826 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P63010-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P83916 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q13113 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q14164 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q15554-4 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q15843 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q6DN90-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q7KZS0 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q86WB0-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8N6T3-3 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8TAI7 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8TC29 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8WUW1 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8WVV9-3 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q96JM7-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9BR81 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9BSL1 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9BYZ2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9H1Y0 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9UI08-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9UK80 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9ULX5 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9UNS2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9Y4K3 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase isozyme L1 20260425 UniProtKB P09936 UCHL1 located_in GO:0005654 nucleoplasm cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251115 UniProtKB P09936 UCHL1 located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251115 UniProtKB P09936 UCHL1 involved_in GO:0016579 protein deubiquitination biological_process ECO:0000304 TAS Reactome:R-HSA-5688426 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251115 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-5690319 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251031 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:12408865 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:12705903 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:16475834 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:20439756 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:23359680 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:25615526 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:8639624 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000269 EXP PMID:9774100 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20251027 UniProtKB P09936 UCHL1 enables GO:0030547 signaling receptor inhibitor activity molecular_function ECO:0000314 IDA PMID:19477270 9606 Homo sapiens BHF-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20250219 UniProtKB P09936 UCHL1 involved_in GO:0043409 negative regulation of MAPK cascade biological_process ECO:0000314 IDA PMID:19477270 9606 Homo sapiens BHF-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20250219 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000315 IMP PMID:34244144 9606 Homo sapiens FlyBase Ubiquitin carboxyl-terminal hydrolase isozyme L1 20240202 UniProtKB P09936 UCHL1 involved_in GO:0045821 positive regulation of glycolytic process biological_process ECO:0000315 IMP PMID:34244144 9606 Homo sapiens FlyBase Ubiquitin carboxyl-terminal hydrolase isozyme L1 20240202 UniProtKB P09936 UCHL1 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000314 IDA PMID:9521656 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20180215 UniProtKB P09936 UCHL1 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5690319 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase isozyme L1 20160519 UniProtKB P09936 UCHL1 involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000304 TAS PMID:24879150 9606 Homo sapiens ParkinsonsUK-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20160218 UniProtKB P09936 UCHL1 enables GO:0031625 ubiquitin protein ligase binding molecular_function ECO:0000353 IPI PMID:19725078 UniProtKB:O60260 9606 Homo sapiens ParkinsonsUK-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20150324 UniProtKB P09936 UCHL1 involved_in GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process ECO:0000303 NAS PMID:24252804 9606 Homo sapiens ParkinsonsUK-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20140911 UniProtKB P09936 UCHL1 located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:19477270 9606 Homo sapiens BHF-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20100624 UniProtKB P09936 UCHL1 colocalizes_with GO:0005886 plasma membrane cellular_component ECO:0000314 IDA PMID:19477270 9606 Homo sapiens BHF-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20100624 UniProtKB P09936 UCHL1 enables GO:0031694 alpha-2A adrenergic receptor binding molecular_function ECO:0000353 IPI PMID:19477270 UniProtKB:P08913 9606 Homo sapiens BHF-UCL Ubiquitin carboxyl-terminal hydrolase isozyme L1 20100624 UniProtKB P09936 UCHL1 located_in GO:0005737 cytoplasm cellular_component ECO:0000304 TAS PMID:16130169 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20051220 UniProtKB P09936 UCHL1 located_in GO:0005737 cytoplasm cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9R0P9 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20041006 UniProtKB P09936 UCHL1 enables GO:0004197 cysteine-type endopeptidase activity molecular_function ECO:0000314 IDA PMID:8639624 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20040405 UniProtKB P09936 UCHL1 enables GO:0008242 omega peptidase activity molecular_function ECO:0000314 IDA PMID:9521656 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20040405 UniProtKB P09936 UCHL1 involved_in GO:0016579 protein deubiquitination biological_process ECO:0000314 IDA PMID:9521656 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20040405 UniProtKB P09936 UCHL1 enables GO:0043130 ubiquitin binding molecular_function ECO:0000314 IDA PMID:9521656 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase isozyme L1 20040405