ID   UMAD1_HUMAN             Reviewed;         137 AA.
AC   C9J7I0; A4D104;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   28-JAN-2026, entry version 92.
DE   RecName: Full=UBAP1-MVB12-associated (UMA)-domain containing protein 1 {ECO:0000312|HGNC:HGNC:48955};
DE   AltName: Full=RPA3 antisense RNA 1 {ECO:0000312|HGNC:HGNC:48955};
DE   AltName: Full=RPA3 opposite strand {ECO:0000312|HGNC:HGNC:48955};
GN   Name=UMAD1 {ECO:0000312|HGNC:HGNC:48955};
GN   Synonyms=RPA3-AS1 {ECO:0000312|HGNC:HGNC:48955}, RPA3OS
GN   {ECO:0000312|HGNC:HGNC:48955};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Caudate nucleus;
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       C9J7I0; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-10989060, EBI-746969;
CC       C9J7I0; P07101-3: TH; NbExp=3; IntAct=EBI-10989060, EBI-12001016;
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DR   EMBL; AK295253; BAG58242.1; -; mRNA.
DR   EMBL; AC004948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236948; EAL24303.1; -; Genomic_DNA.
DR   EMBL; CH471073; EAW93606.1; -; Genomic_DNA.
DR   CCDS; CCDS83158.1; -.
DR   RefSeq; NP_001289277.1; NM_001302348.2.
DR   RefSeq; NP_001289278.1; NM_001302349.2.
DR   AlphaFoldDB; C9J7I0; -.
DR   BioGRID; 610246; 15.
DR   FunCoup; C9J7I0; 329.
DR   IntAct; C9J7I0; 14.
DR   STRING; 9606.ENSP00000489648; -.
DR   iPTMnet; C9J7I0; -.
DR   PhosphoSitePlus; C9J7I0; -.
DR   BioMuta; UMAD1; -.
DR   jPOST; C9J7I0; -.
DR   MassIVE; C9J7I0; -.
DR   PaxDb; 9606-ENSP00000386039; -.
DR   PeptideAtlas; C9J7I0; -.
DR   ProteomicsDB; 601; -.
DR   Pumba; C9J7I0; -.
DR   DNASU; 729852; -.
DR   Ensembl; ENST00000636849.1; ENSP00000489648.1; ENSG00000219545.13.
DR   Ensembl; ENST00000682710.1; ENSP00000507605.1; ENSG00000219545.13.
DR   GeneID; 729852; -.
DR   KEGG; hsa:729852; -.
DR   MANE-Select; ENST00000682710.1; ENSP00000507605.1; NM_001302348.2; NP_001289277.1.
DR   AGR; HGNC:48955; -.
DR   CTD; 729852; -.
DR   DisGeNET; 729852; -.
DR   GeneCards; UMAD1; -.
DR   HGNC; HGNC:48955; UMAD1.
DR   HPA; ENSG00000219545; Low tissue specificity.
DR   NIAGADS; ENSG00000219545; -.
DR   OpenTargets; ENSG00000219545; -.
DR   VEuPathDB; HostDB:ENSG00000219545; -.
DR   eggNOG; ENOG502S575; Eukaryota.
DR   GeneTree; ENSGT00390000003051; -.
DR   InParanoid; C9J7I0; -.
DR   OMA; SPRDINH; -.
DR   OrthoDB; 9872568at2759; -.
DR   PAN-GO; C9J7I0; 0 GO annotations based on evolutionary models.
DR   PathwayCommons; C9J7I0; -.
DR   SignaLink; C9J7I0; -.
DR   Agora; ENSG00000219545; -.
DR   BioGRID-ORCS; 729852; 0 hits in 205 CRISPR screens.
DR   ChiTaRS; UMAD1; human.
DR   GenomeRNAi; 729852; -.
DR   Pharos; C9J7I0; Tdark.
DR   PRO; PR:C9J7I0; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; C9J7I0; protein.
DR   Bgee; ENSG00000219545; Expressed in body of pancreas and 180 other cell types or tissues.
DR   ExpressionAtlas; C9J7I0; baseline and differential.
DR   InterPro; IPR053292; UBAP1-MVB12_assoc_domain.
DR   InterPro; IPR023340; UMA.
DR   PANTHER; PTHR36291; UBAP1-MVB12-ASSOCIATED (UMA)-DOMAIN CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR36291:SF1; UBAP1-MVB12-ASSOCIATED (UMA)-DOMAIN CONTAINING PROTEIN 1; 1.
DR   PROSITE; PS51497; UMA; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification; Reference proteome.
FT   CHAIN           1..137
FT                   /note="UBAP1-MVB12-associated (UMA)-domain containing
FT                   protein 1"
FT                   /id="PRO_0000431388"
FT   DOMAIN          86..134
FT                   /note="UMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00830"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   137 AA;  15200 MW;  BD85FC03B5AF255B CRC64;
     MFHFFRKPPE SKKPSVPETE ADGFVLLGDT TDEQRMTARG KTSDIEANQP LETNKENSSS
     VTVSDPEMEN KAGQTLENSS LMAELLSDVP FTLAPHVLAV QGTITDLPDH LLSYDGSENL
     SRFWYDFTLE NSVLCDS
//