UQCRQ

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0045275 respiratory chain complex III	IBA GO_REF:0000033	ACCEPT	Summary: UQCRQ is a bona fide structural subunit of respiratory chain complex III. Phylogenetically-inferred (IBA) complex membership is fully consistent with UniProt, ComplexPortal (CPX-560) and cryo-EM structural data, and represents a core cellular-component annotation. Reason: UQCRQ/QCR8 is one of the six low-molecular-weight subunits of the 11-subunit cytochrome b-c1 complex; membership is conserved across eukaryotes, so the IBA call is well-founded. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c	IBA GO_REF:0000033	ACCEPT	Summary: As a subunit of Complex III, UQCRQ participates in mitochondrial electron transport from ubiquinol to cytochrome c. This is the core biological process of the complex and the appropriate BP term; the IBA inference is well supported. Reason: Complex III catalyzes electron transfer from ubiquinol to cytochrome c; UQCRQ is an integral structural subunit contributing to this process. Correct level of specificity for the gene's core role. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt The cytochrome b-c1 complex catalyzes electron
GO:0005743 mitochondrial inner membrane	IEA GO_REF:0000120	ACCEPT	Summary: Electronic annotation to the mitochondrial inner membrane, consistent with UniProt subcellular location and the protein's single transmembrane helix. Correct core localization. Reason: UQCRQ is an integral single-pass protein of the mitochondrial inner membrane; the IEA localization agrees with experimental (IDA/ISS/TAS) evidence in the same GOA and with UniProt. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c	IEA GO_REF:0000002	ACCEPT	Summary: InterPro2GO electronic annotation mapping the UcrQ/cytochrome b-c1 subunit 8 domain (IPR004205/IPR036642) to the ubiquinol-to-cytochrome-c electron transport process. Consistent with the manually curated and IBA annotations. Reason: The domain-to-process mapping correctly captures the core process of the complex that this subunit belongs to; duplicates the IBA/NAS BP call at the right level. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt The cytochrome b-c1 complex catalyzes electron
GO:0045275 respiratory chain complex III	IEA GO_REF:0000120	ACCEPT	Summary: Electronic complex-membership annotation, redundant with the IBA and IPI annotations to the same term. Correct core cellular-component annotation. Reason: Consistent with all other lines of evidence for UQCRQ as a Complex III subunit. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,
GO:0021539 subthalamus development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara transfer from a mouse ortholog annotation (ECO:0000265), reflecting the ortholog's developmental expression/phenotype rather than a UQCRQ-specific developmental function. UQCRQ is a ubiquitously required housekeeping respiratory-chain subunit; specific brain-region development is not its core evolved function. Reason: This is an over-annotation: the gene is broadly required for oxidative phosphorylation and its loss (MC3DN4) has neurological consequences, but that does not make discrete subthalamus development a molecular function of UQCRQ. The BP is better captured by mitochondrial electron transport / cellular respiration. Not removed because the annotation stems from a phenotype-based ortholog transfer rather than a demonstrably wrong domain mapping. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021548 pons development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265) capturing the mouse ortholog's developmental expression/phenotype, not a UQCRQ-specific pons development function. Reason: Over-annotation of a housekeeping respiratory subunit; core role is oxidative phosphorylation electron transport, not region-specific hindbrain development. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021680 cerebellar Purkinje cell layer development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265); reflects ortholog developmental expression/phenotype rather than a UQCRQ-specific function. Reason: Over-annotation; UQCRQ's core evolved function is as a structural subunit of Complex III in mitochondrial electron transport, not Purkinje cell layer development. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021766 hippocampus development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265) reflecting ortholog developmental expression/phenotype, not a UQCRQ-specific hippocampus development function. Reason: Over-annotation of a ubiquitous respiratory subunit; core BP is electron transport / cellular respiration. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021794 thalamus development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265); captures the mouse ortholog's developmental expression/phenotype rather than a UQCRQ-specific thalamus development function. Reason: Over-annotation; the gene's core function is Complex III-mediated electron transport, not region-specific brain development. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021854 hypothalamus development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265) reflecting ortholog developmental expression/phenotype, not a UQCRQ-specific hypothalamus development function. Reason: Over-annotation of a housekeeping respiratory-chain subunit; core BP is mitochondrial electron transport / cellular respiration. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0021860 pyramidal neuron development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265); reflects ortholog developmental expression/phenotype rather than a UQCRQ-specific neuronal development function. Reason: Over-annotation; core evolved function is as a Complex III structural subunit in oxidative phosphorylation, not pyramidal neuron development. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0030901 midbrain development	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Automatic Ensembl-Compara ortholog transfer (ECO:0000265) reflecting the mouse ortholog's developmental expression/phenotype, not a UQCRQ-specific midbrain development function. Reason: Over-annotation of a ubiquitous respiratory subunit; core BP is mitochondrial electron transport / cellular respiration. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Component of the ubiquinol-cytochrome c oxidoreductase, a
GO:0005739 mitochondrion	IDA GO_REF:0000052	ACCEPT	Summary: HPA immunofluorescence IDA localizing UQCRQ to the mitochondrion. Correct but less specific than the inner-membrane annotations; retained as a valid, experimentally supported (if general) localization. Reason: Mitochondrial localization is correct and experimentally supported; the more specific inner-membrane annotations refine it but do not contradict it. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0005743 mitochondrial inner membrane	IDA PMID:28844695 Architecture of Human Mitochondrial Respiratory Megacomplex ...	ACCEPT	Summary: ComplexPortal IDA localizing UQCRQ to the mitochondrial inner membrane, backed by the cryo-EM megacomplex structure in which UQCRQ is assigned as a CIII subunit with a defined matrix/transmembrane/intermembrane topology. Core localization annotation. Reason: Directly supported by the structural study and consistent with the single-pass inner-membrane topology recorded in UniProt. Supporting Evidence: PMID:28844695 the precise assignment of individual subunits of file:human/UQCRQ/UQCRQ-uniprot.txt Single-pass membrane protein
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c	NAS PMID:28844695 Architecture of Human Mitochondrial Respiratory Megacomplex ...	ACCEPT	Summary: ComplexPortal NAS annotation of UQCRQ to the ubiquinol-to-cytochrome-c electron transport process, the core biological process of Complex III. Consistent with IBA and InterPro2GO calls to the same term. Reason: Correct core BP; UQCRQ is a structural subunit of the complex that mediates this electron transfer. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt The cytochrome b-c1 complex catalyzes electron
GO:0045275 respiratory chain complex III	IPI PMID:28844695 Architecture of Human Mitochondrial Respiratory Megacomplex ...	ACCEPT	Summary: ComplexPortal IPI complex-membership annotation (CPX-560) placing UQCRQ in respiratory chain complex III, supported by the cryo-EM structure that assigns UQCRQ within the CIII dimer. This is a core, well-evidenced annotation. Reason: Complex III subunit membership is directly demonstrated structurally and by biochemical purification; the appropriate specific cellular-component term. Supporting Evidence: PMID:28844695 the precise assignment of individual subunits of file:human/UQCRQ/UQCRQ-uniprot.txt weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,
GO:0045333 cellular respiration	NAS PMID:28844695 Architecture of Human Mitochondrial Respiratory Megacomplex ...	ACCEPT	Summary: ComplexPortal NAS annotation to cellular respiration. This is a correct broader BP that encompasses the electron-transport role of Complex III; retained as a valid (if more general) process annotation. Reason: Cellular respiration is a correct parent process for UQCRQ's role; not contradicted by any evidence. The more specific GO:0006122 is the preferred core term, but this broader term is legitimate. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt part of the mitochondrial
GO:0005739 mitochondrion	HTP PMID:34800366 Quantitative high-confidence human mitochondrial proteome an...	ACCEPT	Summary: High-throughput proteomics (MitoCoP) placing UQCRQ within the high-confidence human mitochondrial proteome. Supports mitochondrial localization; less specific than the inner-membrane annotations but consistent with them. Reason: Correct, experimentally derived (high-throughput) mitochondrial localization, corroborating the more specific inner-membrane annotations. Supporting Evidence: PMID:34800366 mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP)
GO:0005743 mitochondrial inner membrane	ISS GO_REF:0000024	ACCEPT	Summary: Sequence-similarity localization to the mitochondrial inner membrane, transferred from the bovine ortholog (UniProtKB:P08525). Consistent with the experimental IDA/TAS annotations and UniProt. Reason: Correct core localization; agrees with independent experimental evidence in the same GOA. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0005743 mitochondrial inner membrane	TAS Reactome:R-HSA-164651	ACCEPT	Summary: Reactome TAS localization to the mitochondrial inner membrane, from the pathway "Electron transfer from ubiquinol to cytochrome c of complex III". Correct core localization for a CIII subunit. Reason: Consistent with all other localization evidence; UQCRQ acts within the inner membrane as part of Complex III's Q cycle. Supporting Evidence: Reactome:R-HSA-164651 complex III transfers electrons from ubiquinol to cytochrome c
GO:0005743 mitochondrial inner membrane	TAS Reactome:R-HSA-9837978	ACCEPT	Summary: Reactome TAS localization to the mitochondrial inner membrane, from a mitochondrial-protein-degradation reaction (LONP1 binding inner-membrane proteins). Correct localization annotation. Reason: The inner-membrane localization is correct and consistent with all other evidence for UQCRQ. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0005743 mitochondrial inner membrane	TAS Reactome:R-HSA-9838004	ACCEPT	Summary: Reactome TAS localization to the mitochondrial inner membrane, from a mitochondrial-protein-degradation reaction (LONP1 degrading inner-membrane proteins). Correct localization annotation. Reason: Consistent with the experimentally supported inner-membrane localization. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0005743 mitochondrial inner membrane	TAS Reactome:R-HSA-9906017	ACCEPT	Summary: Reactome TAS localization to the mitochondrial inner membrane, from a Complex III assembly/maturation reaction (cleavage of the UQCRFS1 subunit). Correct localization for a CIII subunit. Reason: Consistent with all other inner-membrane localization evidence. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane
GO:0005743 mitochondrial inner membrane	TAS Reactome:R-HSA-9906042	ACCEPT	Summary: Reactome TAS localization to the mitochondrial inner membrane, from a Complex III maturation reaction (TTC19 clearing UQCRFS1 fragments). Correct localization. Reason: Consistent with the well-supported inner-membrane localization of this CIII subunit. Supporting Evidence: file:human/UQCRQ/UQCRQ-uniprot.txt Mitochondrion inner membrane

Gene Description

Existing Annotations Review

Core Functions

References

📚 Additional Documentation

Notes

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