GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q9UK80 USP21 is_active_in GO:0005737 cytoplasm cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1858178|PANTHER:PTN002541863|RGD:621073|UniProtKB:O75604|UniProtKB:Q9UK80|WB:WBGene00000874 9606 Homo sapiens GO_Central Ubiquitin carboxyl-terminal hydrolase 21 20251219 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000501 IEA GO_REF:0000120 InterPro:IPR001394|InterPro:IPR018200|EC:3.4.19.12 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 located_in GO:0005634 nucleus cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 located_in GO:0005737 cytoplasm cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 enables GO:0008234 cysteine-type peptidase activity molecular_function ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027409 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 involved_in GO:0016579 protein deubiquitination biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR001394 9606 Homo sapiens InterPro Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 involved_in GO:0045893 positive regulation of DNA-templated transcription biological_process ECO:0000364 IEA GO_REF:0000108 GO:0003713 9606 Homo sapiens GOC Ubiquitin carboxyl-terminal hydrolase 21 20260601 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19615732 UniProtKB:P09936 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q6A162 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:O95967 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q16630-2 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q6UY14-3 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q7L273 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9NYD6 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P09936 9606 Homo sapiens IntAct Ubiquitin carboxyl-terminal hydrolase 21 20260530 UniProtKB Q9UK80 USP21 involved_in GO:0016579 protein deubiquitination biological_process ECO:0000304 TAS Reactome:R-HSA-5688426 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20260316 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-5690157 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20260222 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-5690159 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20260222 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000304 TAS Reactome:R-HSA-6783177 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20260222 UniProtKB Q9UK80 USP21 located_in GO:0005654 nucleoplasm cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Ubiquitin carboxyl-terminal hydrolase 21 20251115 UniProtKB Q9UK80 USP21 located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Ubiquitin carboxyl-terminal hydrolase 21 20251115 UniProtKB Q9UK80 USP21 located_in GO:0005654 nucleoplasm cellular_component ECO:0000304 TAS Reactome:R-HSA-5690157 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20231101 UniProtKB Q9UK80 USP21 located_in GO:0005654 nucleoplasm cellular_component ECO:0000304 TAS Reactome:R-HSA-6783177 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20231101 UniProtKB Q9UK80 USP21 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5690159 9606 Homo sapiens Reactome Ubiquitin carboxyl-terminal hydrolase 21 20231101 UniProtKB Q9UK80 USP21 located_in GO:0005634 nucleus cellular_component ECO:0000269 EXP PMID:21888622 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20230412 UniProtKB Q9UK80 USP21 located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:21888622 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20230412 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000314 IDA PMID:32011234 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20230216 UniProtKB Q9UK80 USP21 involved_in GO:0016579 protein deubiquitination biological_process ECO:0000314 IDA PMID:32011234 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20230216 UniProtKB Q9UK80 USP21 involved_in GO:0045815 transcription initiation-coupled chromatin remodeling biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9QZL6 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20230123 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9QZL6 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20170516 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000315 IMP PMID:26100909 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20150721 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:26100909 UniProtKB:Q5T5X7 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20150720 UniProtKB Q9UK80 USP21 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:26100909 UniProtKB:Q9UIF9 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20150720 UniProtKB Q9UK80 USP21 enables GO:0008234 cysteine-type peptidase activity molecular_function ECO:0000315 IMP PMID:10799498 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20090330 UniProtKB Q9UK80 USP21 enables GO:0004843 cysteine-type deubiquitinase activity molecular_function ECO:0000314 IDA PMID:10799498 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20090326 UniProtKB Q9UK80 USP21 enables GO:0019784 deNEDDylase activity molecular_function ECO:0000314 IDA PMID:10799498 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20090326 UniProtKB Q9UK80 USP21 enables GO:0003713 transcription coactivator activity molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9QZL6 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20090306 UniProtKB Q9UK80 USP21 enables GO:0008234 cysteine-type peptidase activity molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9QZL6 9606 Homo sapiens UniProt Ubiquitin carboxyl-terminal hydrolase 21 20090306