id: Q9H9H4
gene_symbol: VPS37B
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: VPS37B is a VPS37-family ESCRT-I subunit that complexes with TSG101, VPS28, and MVB12/UBAP-family
  subunits. It supports ESCRT-I-dependent endosomal sorting of ubiquitinated cargo into multivesicular bodies 
  and contributes to ESCRT-I membrane-remodeling contexts. Current local evidence does not support 
  transferring the VPS37A-specific phagophore-closure role to VPS37B as a core annotation.
existing_annotations:
- term:
    id: GO:0043162
    label: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway is 
      supported as part of the core VPS37B/ESCRT-I endosomal cargo-sorting role.
    action: ACCEPT
    reason: VPS37B/ESCRT-I supports ubiquitin-dependent endosomal cargo sorting and MVB biogenesis.
    additional_reference_ids: &id001
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id002
    - &id012
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: Required for the sorting of endocytic
    - &id013
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: ubiquitinated cargos into multivesicular bodies
    - &id014
      reference_id: PMID:15218037
      supporting_text: sorting ubiquitylated protein cargoes into multivesicular bodies
    - &id015
      reference_id: PMID:21757351
      supporting_text: required for sorting EGFR to the MVB
    - &id016
      reference_id: PMID:22405001
      supporting_text: endosomal sorting of ubiquitinated cargo, MVB biogenesis
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: &id003
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id004
    - &id005
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: Component of the ESCRT-I complex
    - &id006
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: which consists of TSG101, VPS28, a VPS37
    - &id007
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: Interacts with TSG101, VPS28, MVB12A and MVB12B
    - &id008
      reference_id: PMID:15218037
      supporting_text: VPS37A and VPS37B bind TSG101
    - &id009
      reference_id: PMID:15218037
      supporting_text: TSG101 and VPS28 co-immunoprecipitated with VPS37B-FLAG
    - &id010
      reference_id: PMID:18005716
      supporting_text: All ESCRT-I complexes contain three
    - &id011
      reference_id: PMID:32424346
      supporting_text: comprising TSG101-VPS28-VPS37B-MVB12A
- term:
    id: GO:0006612
    label: protein targeting to membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: protein targeting to membrane is too broad for VPS37B ESCRT-I function.
    action: MODIFY
    reason: The supported process is ESCRT-I-dependent endosomal cargo sorting into the MVB pathway, not 
      generic protein targeting.
    proposed_replacement_terms:
    - id: GO:0043162
      label: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
    - id: GO:0036258
      label: multivesicular body assembly
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0006623
    label: protein targeting to vacuole
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: protein targeting to vacuole is too broad for VPS37B ESCRT-I function.
    action: MODIFY
    reason: The supported process is ESCRT-I-dependent endosomal cargo sorting into the MVB pathway, not 
      generic protein targeting.
    proposed_replacement_terms:
    - id: GO:0043162
      label: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
    - id: GO:0036258
      label: multivesicular body assembly
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0016236
    label: macroautophagy
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: Macroautophagy is over-annotated for VPS37B.
    action: MARK_AS_OVER_ANNOTATED
    reason: The accessible ESCRT autophagy evidence is broad or VPS37A-specific; there is not enough direct 
      evidence to make VPS37B a phagophore-closure/autophagosome assembly factor.
    proposed_replacement_terms:
    - id: GO:0000813
      label: ESCRT I complex
    - id: GO:0090148
      label: membrane fission
    additional_reference_ids: &id020
    - PMID:20588296
    - PMID:31519728
    - PMID:32424346
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id021
    - reference_id: PMID:20588296
      supporting_text: viral budding, cytokinesis and, probably, autophagy
    - reference_id: PMID:31519728
      supporting_text: the ESCRT-I subunit VPS37A as a critical component for phagophore closure
    - reference_id: PMID:31519728
      supporting_text: required for autophagosome completion but dispensable for ESCRT-I complex formation
- term:
    id: GO:0031902
    label: late endosome membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: late endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: &id018
    - PMID:15218037
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id019
    - &id026
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: Late endosome membrane
    - &id027
      reference_id: file:human/VPS37B/VPS37B-uniprot.txt
      supporting_text: Recruited to the endosomal membrane
    - &id028
      reference_id: PMID:15218037
      supporting_text: VPS37B became trapped on aberrant endosomal compartments
- term:
    id: GO:0036258
    label: multivesicular body assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: multivesicular body assembly is supported as part of the core VPS37B/ESCRT-I endosomal 
      cargo-sorting role.
    action: ACCEPT
    reason: VPS37B/ESCRT-I supports ubiquitin-dependent endosomal cargo sorting and MVB biogenesis.
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0039702
    label: viral budding via host ESCRT complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: viral budding via host ESCRT complex is supported as a secondary context but is not the core 
      VPS37B proteostasis function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: &id022
    - PMID:15218037
    - PMID:18005716
    - PMID:19129479
    - PMID:20588296
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id023
    - reference_id: PMID:15218037
      supporting_text: recruit TSG101/ESCRT-I activity and thereby rescue the budding
    - reference_id: PMID:18005716
      supporting_text: plays essential roles in HIV budding and endosomal protein sorting
    - reference_id: PMID:19129479
      supporting_text: functions in the terminal stages of cytokinesis
    - reference_id: PMID:20588296
      supporting_text: viral budding, cytokinesis and, probably, autophagy
- term:
    id: GO:0048306
    label: calcium-dependent protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: enables
  review:
    summary: Calcium-dependent protein binding is supported but secondary.
    action: KEEP_AS_NON_CORE
    reason: VPS37B participates in an ALG-2/ALIX/ESCRT-I calcium-dependent ternary complex, but this is not 
      the core VPS37B proteostasis function.
    additional_reference_ids: &id024
    - PMID:23924735
    - file:human/VPS37B/VPS37B-notes.md
    supported_by: &id025
    - reference_id: PMID:23924735
      supporting_text: VPS37B and VPS37C appeared to interact with ALG-2
    - reference_id: PMID:23924735
      supporting_text: adaptor protein that bridges ALIX and ESCRT-I
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21516116
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: &id017
    - id: GO:0000813
      label: ESCRT I complex
    - id: GO:0043162
      label: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416956
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26871637
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31515488
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IPI
  original_reference_id: PMID:18005716
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IPI
  original_reference_id: PMID:21757351
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IPI
  original_reference_id: PMID:32424346
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: NAS
  original_reference_id: PMID:32424346
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0036258
    label: multivesicular body assembly
  evidence_type: NAS
  original_reference_id: PMID:32424346
  qualifier: involved_in
  review:
    summary: multivesicular body assembly is supported as part of the core VPS37B/ESCRT-I endosomal 
      cargo-sorting role.
    action: ACCEPT
    reason: VPS37B/ESCRT-I supports ubiquitin-dependent endosomal cargo sorting and MVB biogenesis.
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0043328
    label: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the 
      multivesicular body sorting pathway
  evidence_type: NAS
  original_reference_id: PMID:32424346
  qualifier: involved_in
  review:
    summary: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the 
      multivesicular body sorting pathway is supported as part of the core VPS37B/ESCRT-I endosomal 
      cargo-sorting role.
    action: ACCEPT
    reason: VPS37B/ESCRT-I supports ubiquitin-dependent endosomal cargo sorting and MVB biogenesis.
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0090148
    label: membrane fission
  evidence_type: NAS
  original_reference_id: PMID:32424346
  qualifier: involved_in
  review:
    summary: Membrane fission is supported for ESCRT-I reverse-topology membrane remodeling.
    action: ACCEPT
    reason: VPS37B is part of the human ESCRT-I headpiece structure, and ESCRT-I scaffolds reverse-topology 
      membrane remodeling upstream of ESCRT-III.
    additional_reference_ids:
    - PMID:20588296
    - PMID:32424346
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - &id029
      reference_id: PMID:20588296
      supporting_text: ESCRT-I and ESCRT-II direct membrane budding away from the cytosol
    - &id030
      reference_id: PMID:32424346
      supporting_text: A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission
    - &id031
      reference_id: PMID:32424346
      supporting_text: ESCRT-I is not merely a bridging adaptor
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18005716
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0016236
    label: macroautophagy
  evidence_type: TAS
  original_reference_id: PMID:20588296
  qualifier: involved_in
  review:
    summary: Macroautophagy is over-annotated for VPS37B.
    action: MARK_AS_OVER_ANNOTATED
    reason: The accessible ESCRT autophagy evidence is broad or VPS37A-specific; there is not enough direct 
      evidence to make VPS37B a phagophore-closure/autophagosome assembly factor.
    proposed_replacement_terms:
    - id: GO:0000813
      label: ESCRT I complex
    - id: GO:0090148
      label: membrane fission
    additional_reference_ids: *id020
    supported_by: *id021
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: TAS
  original_reference_id: PMID:20588296
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0036258
    label: multivesicular body assembly
  evidence_type: TAS
  original_reference_id: PMID:20588296
  qualifier: involved_in
  review:
    summary: multivesicular body assembly is supported as part of the core VPS37B/ESCRT-I endosomal 
      cargo-sorting role.
    action: ACCEPT
    reason: VPS37B/ESCRT-I supports ubiquitin-dependent endosomal cargo sorting and MVB biogenesis.
    additional_reference_ids: *id001
    supported_by: *id002
- term:
    id: GO:0039702
    label: viral budding via host ESCRT complex
  evidence_type: TAS
  original_reference_id: PMID:20588296
  qualifier: involved_in
  review:
    summary: viral budding via host ESCRT complex is supported as a secondary context but is not the core 
      VPS37B proteostasis function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IDA
  original_reference_id: PMID:18005716
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0005768
    label: endosome
  evidence_type: IDA
  original_reference_id: PMID:17940959
  qualifier: located_in
  review:
    summary: endosome localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:17940959
  qualifier: located_in
  review:
    summary: plasma membrane is supported as a secondary context but is not the core VPS37B proteostasis 
      function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:1903774
    label: positive regulation of viral budding via host ESCRT complex
  evidence_type: IMP
  original_reference_id: PMID:15218037
  qualifier: involved_in
  review:
    summary: positive regulation of viral budding via host ESCRT complex is supported as a secondary context 
      but is not the core VPS37B proteostasis function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15218037
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:15218037
  qualifier: located_in
  review:
    summary: cytoplasm is supported as a secondary context but is not the core VPS37B proteostasis function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: IDA
  original_reference_id: PMID:15218037
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0019076
    label: viral release from host cell
  evidence_type: IMP
  original_reference_id: PMID:15218037
  qualifier: involved_in
  review:
    summary: viral release from host cell is supported as a secondary context but is not the core VPS37B 
      proteostasis function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0048306
    label: calcium-dependent protein binding
  evidence_type: IPI
  original_reference_id: PMID:23924735
  qualifier: enables
  review:
    summary: Calcium-dependent protein binding is supported but secondary.
    action: KEEP_AS_NON_CORE
    reason: VPS37B participates in an ALG-2/ALIX/ESCRT-I calcium-dependent ternary complex, but this is not 
      the core VPS37B proteostasis function.
    additional_reference_ids: *id024
    supported_by: *id025
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:23533145
  qualifier: located_in
  review:
    summary: extracellular exosome is supported as a secondary context but is not the core VPS37B proteostasis
      function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IDA
  original_reference_id: PMID:22232651
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:19056867
  qualifier: located_in
  review:
    summary: extracellular exosome is supported as a secondary context but is not the core VPS37B proteostasis
      function.
    action: KEEP_AS_NON_CORE
    reason: Viral budding/release, exosome, plasma membrane, and broad cytoplasmic contexts use or detect 
      ESCRT machinery but are secondary to the core endosomal ESCRT-I sorting role.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0000813
    label: ESCRT I complex
  evidence_type: IDA
  original_reference_id: PMID:22405001
  qualifier: part_of
  review:
    summary: ESCRT-I complex membership is the central VPS37B cellular-component annotation.
    action: ACCEPT
    reason: VPS37B is a VPS37-family ESCRT-I subunit in TSG101-VPS28-VPS37-MVB12/UBAP variant complexes.
    additional_reference_ids: *id003
    supported_by: *id004
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-184269
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3149434
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3159232
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-917696
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0010008
    label: endosome membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-917730
  qualifier: located_in
  review:
    summary: endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
    action: ACCEPT
    reason: VPS37B is a peripheral late-endosome/endosome-membrane ESCRT-I component recruited to endosomal 
      membranes in the VPS4-dependent ESCRT cycle.
    additional_reference_ids: *id018
    supported_by: *id019
- term:
    id: GO:0030496
    label: midbody
  evidence_type: IDA
  original_reference_id: PMID:19129479
  qualifier: located_in
  review:
    summary: Midbody localization is a secondary ESCRT/cytokinesis context and is not core for VPS37B.
    action: KEEP_AS_NON_CORE
    reason: ESCRT machinery functions in cytokinesis, and VPS37B interacts with IST1, but the core 
      proteostasis review focus is endosomal ESCRT-I sorting and membrane remodeling.
    additional_reference_ids: *id022
    supported_by: *id023
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19129479
  qualifier: enables
  review:
    summary: Protein binding is too generic to represent VPS37B function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The informative function is ESCRT-I complex membership and ESCRT-I-mediated endosomal 
      sorting/membrane remodeling, not generic protein binding from interaction assays.
    proposed_replacement_terms: *id017
    additional_reference_ids:
    - PMID:15218037
    - PMID:18005716
    - PMID:21757351
    - PMID:22405001
    - PMID:32424346
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    - PMID:15218037
    - PMID:21757351
    - PMID:22405001
    - file:human/VPS37B/VPS37B-uniprot.txt
    - file:human/VPS37B/VPS37B-notes.md
    supported_by:
    - *id005
    - *id006
    - *id007
    - *id008
    - *id009
    - *id010
    - *id011
    - *id012
    - *id013
    - *id014
    - *id015
    - *id016
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, 
    accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:15218037
  title: The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.
  findings: []
- id: PMID:17940959
  title: Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 
    interaction.
  findings: []
- id: PMID:18005716
  title: Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.
  findings: []
- id: PMID:19056867
  title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  findings: []
- id: PMID:19129479
  title: Biochemical analyses of human IST1 and its function in cytokinesis.
  findings: []
- id: PMID:20588296
  title: "Membrane budding and scission by the ESCRT machinery: it's all in the neck."
  findings: []
- id: PMID:21516116
  title: Next-generation sequencing to generate interactome datasets.
  findings: []
- id: PMID:21757351
  title: UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
  findings: []
- id: PMID:22232651
  title: Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I 
    MVB12 subunit.
  findings: []
- id: PMID:22405001
  title: The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
  findings: []
- id: PMID:23533145
  title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  findings: []
- id: PMID:23924735
  title: VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.
  findings: []
- id: PMID:25416956
  title: A proteome-scale map of the human interactome network.
  findings: []
- id: PMID:26871637
  title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
  findings: []
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and disease networks.
  findings: []
- id: PMID:31515488
  title: Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum
    in human populations.
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32424346
  title: A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: Reactome:R-HSA-184269
  title: Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by 
    the ESCRT-I complex
  findings: []
- id: Reactome:R-HSA-3149434
  title: Transport of GAG to the Plasma Membrane
  findings: []
- id: Reactome:R-HSA-3159232
  title: Recruitment Of HIV Virion Budding Machinery
  findings: []
- id: Reactome:R-HSA-917696
  title: Cargo Sequestration
  findings: []
- id: Reactome:R-HSA-917730
  title: Cargo Recognition And Sorting
  findings: []
- id: PMID:31519728
  title: VPS37A directs ESCRT recruitment for phagophore closure.
  findings: []
- id: file:human/VPS37B/VPS37B-uniprot.txt
  title: UniProtKB record for human VPS37B
  findings: []
- id: file:human/VPS37B/VPS37B-notes.md
  title: VPS37B review notes
  findings: []
core_functions:
- description: VPS37B is a structural ESCRT-I subunit that helps organize the TSG101-VPS28-VPS37-MVB12/UBAP 
    complex for ubiquitin-dependent endosomal cargo sorting, MVB assembly, and ESCRT-I-linked reverse-topology
    membrane remodeling.
  directly_involved_in:
  - id: GO:0043162
    label: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  - id: GO:0036258
    label: multivesicular body assembly
  - id: GO:0090148
    label: membrane fission
  locations:
  - id: GO:0010008
    label: endosome membrane
  - id: GO:0031902
    label: late endosome membrane
  - id: GO:0005768
    label: endosome
  in_complex:
    id: GO:0000813
    label: ESCRT I complex
  supported_by:
  - *id005
  - *id006
  - *id007
  - *id008
  - *id009
  - *id010
  - *id011
  - *id012
  - *id013
  - *id014
  - *id015
  - *id016
  - *id026
  - *id027
  - *id028
  - *id029
  - *id030
  - *id031
proposed_new_terms: []
suggested_questions:
- question: Should VPS37B macroautophagy annotations be retired or kept non-core given that the direct 
    phagophore-closure evidence is VPS37A-specific?
  experts:
  - GO autophagy editors
  - GO ESCRT curators
- question: Should generic VPS37B protein-binding annotations be replaced by ESCRT-I complex membership and 
    specific endosomal sorting terms?
  experts:
  - GO molecular function editors
  - UniProt curators
suggested_experiments:
- experiment_type: VPS37 paralog phagophore closure comparison
  hypothesis: VPS37A, but not VPS37B, is the VPS37 paralog specialized for phagophore closure because VPS37B 
    lacks the VPS37A PUEV-dependent targeting function.
  description: Compare VPS37A, VPS37B, and VPS37C depletion/rescue in HT-LC3 autophagosome closure assays and 
    parallel EGFR MVB-sorting assays, using endogenous expression or matched rescue levels.