WEE1 is a predominantly nuclear protein tyrosine kinase that inhibits cyclin-dependent kinases by phosphorylating their inhibitory tyrosine residue, especially CDK1 Tyr15. It restrains mitotic entry until DNA replication is complete and participates in replication and DNA-damage checkpoints. Its activity and abundance are controlled by phosphorylation, binding partners and ubiquitin-dependent degradation. WEE1 is distinct from the oocyte-enriched paralog WEE2.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000086 G2/M transition of mitotic cell cycle | TAS Reactome:R-HSA-69275 | ACCEPT | Summary: WEE1 restrains entry into mitosis. Reason: The primary human experiments establish inhibitory CDK phosphorylation and maintenance of mitotic timing. The broad cell-cycle terms encompass this specific checkpoint role. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0000278 mitotic cell cycle | IEA GO_REF:0000002 | ACCEPT | Summary: WEE1 restrains entry into mitosis. Reason: The primary human experiments establish inhibitory CDK phosphorylation and maintenance of mitotic timing. The broad cell-cycle terms encompass this specific checkpoint role. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0000287 magnesium ion binding | IEA GO_REF:0000002 | ACCEPT | Summary: Magnesium supports WEE1 kinase catalysis. Reason: The curated human structural record identifies two magnesium ions in the nucleotide-binding catalytic site. This cofactor annotation is consistent with the experimentally established ATP-dependent kinase reaction. Supporting Evidence: file:human/WEE1/WEE1-uniprot.txt Note=Binds 2 magnesium ions per subunit. {ECO:0000269|PubMed:15837193} |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: Protein tyrosine kinase activity is the informative catalytic assignment. Reason: Human substrate assays resolve inhibitory CDK1 Tyr15 phosphorylation; use the specific activity rather than the generic kinase ancestor. Proposed replacements: protein tyrosine kinase activity Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:8348613 Human wee1 maintains mitotic timing by protecting the nucleu... | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7743995 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during... | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:8428596 Human Wee1 kinase inhibits cell division by phosphorylating ... | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000116 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:7774574 Cell cycle regulation of human WEE1. | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-170070 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-170156 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-174164 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-69195 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: WEE1 directly phosphorylates CDK tyrosine. Reason: Purified human kinase and cellular experiments establish tyrosine specificity and the non-receptor, intracellular role. Membership in a Ser/Thr-like structural kinase family does not determine substrate specificity. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0005515 protein binding | IPI PMID:15070733 M-phase kinases induce phospho-dependent ubiquitination of s... | KEEP AS NON CORE | Summary: Phosphorylation-dependent interactions regulate WEE1 degradation. Reason: The primary study identifies beta-TrCP recognition of WEE1 phosphodegrons. Retain regulatory interaction records without making generic protein binding a core activity. Supporting Evidence: PMID:15070733 recognition of Wee1A by beta-TrCP depended on phosphorylation |
| GO:0005515 protein binding | IPI PMID:15070733 M-phase kinases induce phospho-dependent ubiquitination of s... | KEEP AS NON CORE | Summary: Phosphorylation-dependent interactions regulate WEE1 degradation. Reason: The primary study identifies beta-TrCP recognition of WEE1 phosphodegrons. Retain regulatory interaction records without making generic protein binding a core activity. Supporting Evidence: PMID:15070733 recognition of Wee1A by beta-TrCP depended on phosphorylation |
| GO:0005515 protein binding | IPI PMID:15070733 M-phase kinases induce phospho-dependent ubiquitination of s... | KEEP AS NON CORE | Summary: Phosphorylation-dependent interactions regulate WEE1 degradation. Reason: The primary study identifies beta-TrCP recognition of WEE1 phosphodegrons. Retain regulatory interaction records without making generic protein binding a core activity. Supporting Evidence: PMID:15070733 recognition of Wee1A by beta-TrCP depended on phosphorylation |
| GO:0005515 protein binding | IPI PMID:15161933 Comprehensive proteomic analysis of interphase and mitotic 1... | UNDECIDED | Summary: The specific 14-3-3 interaction needs its assay record. Reason: A 14-3-3 regulatory interaction is biologically plausible, but the abstract-only screen does not expose the WEE1-specific row or partner identity. Retain uncertainty pending the full supplementary interaction record. |
| GO:0005515 protein binding | IPI PMID:15778465 Targeted proteomic analysis of 14-3-3 sigma, a p53 effector ... | KEEP AS NON CORE | Summary: WEE1 is detected in the 14-3-3 sigma interaction study. Reason: The primary abstract explicitly identifies WEE1 among cell-cycle interactors. This is regulation of the kinase rather than an independent core binding function. Supporting Evidence: PMID:15778465 Among the 92 interactors with known function were a number of proteins previously implicated in oncogenic signaling (APC, A-RAF, B-RAF, and c-RAF) and cell cycle regulation (AJUBA, c-TAK, PTOV-1, and WEE1). |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | UNDECIDED | Summary: The exact interaction requires gene- and partner-specific evidence. Reason: The primary high-throughput interaction record has not been resolved at partner level in the accessible material. The presence of other well-established WEE1 partners does not validate this particular interaction; no removal is warranted from this evidence gap. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP is the phosphate donor for WEE1 catalysis. Reason: Direct kinase activity establishes nucleotide use; the ATP-binding site belongs to the conserved kinase domain. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005634 nucleus | IDA PMID:8348613 Human wee1 maintains mitotic timing by protecting the nucleu... | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005634 nucleus | TAS PMID:8348613 Human wee1 maintains mitotic timing by protecting the nucleu... | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-156699 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-170070 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-170156 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-174164 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-69195 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9929535 | ACCEPT | Summary: WEE1 performs its checkpoint role in the nucleus. Reason: Human localization and mitotic timing experiments establish a nuclear pool protecting the nucleus from activated CDK1. Nucleoplasm is consistent with the characterized soluble nuclear reaction. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005730 nucleolus | IDA GO_REF:0000052 | UNDECIDED | Summary: The HPA-specific nucleolar pool needs image-level assessment. Reason: The primary literature establishes nuclear WEE1, but this does not specifically establish nucleolar localization. The HPA imaging row should be retained for review of the cell-line and antibody images. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: A cytoplasmic pool is compatible with regulated WEE1 distribution. Reason: Retain the phylogenetic/ortholog-supported additional compartment; the best-defined checkpoint action is nuclear. Nuclear enrichment does not exclude cytoplasmic residence. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: A cytoplasmic pool is compatible with regulated WEE1 distribution. Reason: Retain the phylogenetic/ortholog-supported additional compartment; the best-defined checkpoint action is nuclear. Nuclear enrichment does not exclude cytoplasmic residence. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis |
| GO:0010972 negative regulation of G2/M transition of mitotic cell cycle | IBA GO_REF:0000033 | ACCEPT | Summary: WEE1 inhibits the G2/M transition by inhibiting CDK1. Reason: Inhibitory Tyr15 phosphorylation and cellular mitotic delay establish the direction and mechanism of the process. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0010972 negative regulation of G2/M transition of mitotic cell cycle | IDA PMID:7743995 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during... | ACCEPT | Summary: WEE1 inhibits the G2/M transition by inhibiting CDK1. Reason: Inhibitory Tyr15 phosphorylation and cellular mitotic delay establish the direction and mechanism of the process. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0010972 negative regulation of G2/M transition of mitotic cell cycle | IDA PMID:8348613 Human wee1 maintains mitotic timing by protecting the nucleu... | ACCEPT | Summary: WEE1 inhibits the G2/M transition by inhibiting CDK1. Reason: Inhibitory Tyr15 phosphorylation and cellular mitotic delay establish the direction and mechanism of the process. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0010972 negative regulation of G2/M transition of mitotic cell cycle | IDA PMID:8428596 Human Wee1 kinase inhibits cell division by phosphorylating ... | ACCEPT | Summary: WEE1 inhibits the G2/M transition by inhibiting CDK1. Reason: Inhibitory Tyr15 phosphorylation and cellular mitotic delay establish the direction and mechanism of the process. Supporting Evidence: PMID:8428596 purified human Wee1 phosphorylates p34cdc2 exclusively on Tyr15 in vitro; no Thr14 phosphorylation was detected. PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:0045740 positive regulation of DNA replication | TAS Reactome:R-HSA-69656 | UNDECIDED | Summary: The positive DNA-replication regulation assignment needs reaction-context tracing. Reason: WEE1 permits completion of replication by restraining CDKs and preventing premature mitosis; that does not by itself establish a direct positive regulator of replication initiation or synthesis. Inspect the cited Reactome event and its primary mechanistic basis before choosing the process term. Supporting Evidence: PMID:8348613 the human wee1-like tyrosine kinase is a nuclear protein that ensures the completion of DNA replication prior to mitosis PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
| GO:2000134 negative regulation of G1/S transition of mitotic cell cycle | TAS Reactome:R-HSA-69195 | KEEP AS NON CORE | Summary: WEE1 also restrains cell-cycle CDK activity outside mitotic entry. Reason: The broad CDK-inhibitory role is consistent with G1/S control, while its core checkpoint assignment is negative G2/M regulation. Retain the curated pathway assertion as an additional context. Supporting Evidence: PMID:7743995 WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2. |
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