id: P63104
gene_symbol: YWHAZ
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: >-
  14-3-3 protein zeta/delta (YWHAZ) is an adapter protein that functions as a dimeric
  scaffold recognizing phosphoserine/phosphothreonine motifs in client proteins. The
  core molecular function is phosphoserine/phosphothreonine-dependent protein binding
  within a conserved amphipathic groove formed by helices C/E/G/I. YWHAZ forms homodimers
  and heterodimers (notably with YWHAE) and primarily localizes to the cytosol, though
  it can shuttle to the nucleus with certain clients. Key functional roles include:
  (1) cytoplasmic sequestration of transcription factors (FOXO family, YAP/TAZ, TFEB);
  (2) regulation of RAF/MEK/ERK MAPK signaling by scaffolding RAF kinases; (3) modulation
  of PI3K-AKT pathway through BAD sequestration and regulation of mTORC1 via raptor binding;
  (4) regulation of cell cycle checkpoints via CDC25 phosphatase binding; (5) protein
  stabilization through chaperone-like activity. The protein binds hundreds of client
  proteins in a phosphorylation-dependent manner via canonical Mode I (RSXpSXP), Mode II
  (RXY/FXpSXP), and Mode III (C-terminal pS/pT) motifs.
existing_annotations:
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        YWHAZ is predominantly cytosolic as confirmed by multiple studies and consistent
        with its role as a cytoplasmic scaffold protein that sequesters phosphorylated
        client proteins. The IBA annotation is phylogenetically conserved across the
        14-3-3 family. Deep research (YWHAZ-deep-research-falcon.md) confirms cytoplasmic
        localization as the primary subcellular location.
      action: ACCEPT
      reason: >-
        Cytoplasmic localization is a core feature of 14-3-3 proteins. The deep research
        states "14-3-3ζ is predominantly cytosolic but shuttles with clients, often
        retaining transcription factors or signaling enzymes in the cytoplasm".
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0008104
      label: intracellular protein localization
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        A core function of 14-3-3 proteins is regulating the intracellular localization
        of client proteins, particularly retaining phosphorylated transcription factors
        (FOXO, YAP/TAZ, TFEB) and signaling molecules (BAD, RAF1) in the cytoplasm.
        Deep research (YWHAZ-deep-research-falcon.md) extensively documents this role.
      action: ACCEPT
      reason: >-
        This is a conserved core function. The deep research confirms "14-3-3ζ sequesters
        phosphorylated BAD (e.g., pSer112/136) to block mitochondrial translocation" and
        "binds FOXO transcription factors to regulate nuclear access". Also documents
        "14-3-3 binds phosphorylated YAP/TAZ, retaining them in the cytoplasm".
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: >-
        YWHAZ participates in multiple signaling pathways as a scaffold and regulator,
        including RAF/MEK/ERK, PI3K/AKT, and Hippo pathways. This is a conserved function
        across the 14-3-3 family. Deep research (YWHAZ-deep-research-falcon.md) documents
        extensive pathway involvement.
      action: ACCEPT
      reason: >-
        Signal transduction involvement is well-documented. The deep research details
        "14-3-3 dimers scaffold and regulate RAF family kinases via binding to conserved
        phosphorylated motifs, influencing RAF activation states and MAPK signaling
        outputs" and documents roles in PI3K-AKT and Hippo pathways.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: >-
        Duplicate of IBA annotation for cytoplasm. IEA annotation based on UniProt
        subcellular location vocabulary mapping is consistent with experimental evidence.
      action: ACCEPT
      reason: >-
        Cytoplasmic localization is well-established for YWHAZ and duplicates with IBA
        evidence are acceptable. Deep research confirms cytoplasm as primary location.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0042470
      label: melanosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: >-
        YWHAZ was identified in melanosomes in the proteomic study PMID:17081065. While
        this represents a valid observation, melanosome localization is likely not a
        core function but rather reflects the protein's widespread cytoplasmic distribution
        and potential client interactions in pigment cells.
      action: KEEP_AS_NON_CORE
      reason: >-
        The melanosome localization was experimentally observed in proteomic studies
        but does not represent a core localization. YWHAZ is a broadly expressed
        cytoplasmic protein that may be found in various organelles based on client
        interactions.
      additional_reference_ids:
        - PMID:17081065
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: >-
        YWHAZ forms homodimers, a well-established property of 14-3-3 proteins. This
        annotation captures the self-association that is fundamental to 14-3-3 function.
        Deep research confirms the dimeric nature and homodimerization.
      action: ACCEPT
      reason: >-
        Homodimerization is a core property of 14-3-3 proteins. UniProt documents
        "Homodimer" and the deep research states "14-3-3 proteins form obligate dimers"
        and describes "the dimer interface involves N-terminal helices".
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10102273
    review:
      summary: >-
        Documents interaction between YWHAZ and phosphorylated FKHRL1 (FOXO3). The
        paper shows Akt phosphorylates FKHRL1, leading to 14-3-3 binding and cytoplasmic
        retention. While "protein binding" is generic, this represents a bona fide
        phosphoserine-dependent interaction characteristic of 14-3-3 function.
      action: ACCEPT
      reason: >-
        Valid interaction demonstrating core 14-3-3 function. The term is generic but
        captures real binding activity. More specific term would be "phosphoserine
        residue binding" but protein binding is acceptable for IPI evidence of physical
        interaction.
      supported_by:
        - reference_id: PMID:10102273
          supporting_text: >-
            Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3
            proteins and FKHRL1's retention in the cytoplasm.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10642536
    review:
      summary: >-
        Documents interaction between YWHAZ and IL-9R alpha-chain. This is a
        phosphorylation-dependent interaction with a cytokine receptor, representing
        one of many client proteins for 14-3-3 scaffolds.
      action: ACCEPT
      reason: >-
        Valid phosphoserine-dependent interaction. The paper demonstrates physical
        binding between YWHAZ and IL9R alpha-chain requiring phosphorylation.
      supported_by:
        - reference_id: PMID:10642536
          supporting_text: >-
            We have identified 14-3-3zeta as an hIL-9Ralpha-interacting protein. We
            also mapped residues 518-522 (Arg-Ser(519)-Trp-Thr(521)-Phe) in hIL-9Ralpha
            and helix I of 14-3-3zeta as being important for interaction.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10713667
    review:
      summary: >-
        Documents interaction between YWHAZ and CDC25B phosphatase. 14-3-3 binding
        to CDC25 phosphatases regulates cell cycle progression by modulating CDC25
        localization and activity.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction. CDC25 phosphatases are well-established
        14-3-3 binding partners involved in cell cycle regulation. Deep research
        confirms 14-3-3 role in regulating phosphatases.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10840038
    review:
      summary: >-
        Documents interaction between YWHAZ and tau protein. 14-3-3 proteins can bind
        phosphorylated tau and influence its phosphorylation state, relevant to
        neurodegenerative disease.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction. Tau is a well-documented 14-3-3 interactor
        with relevance to Alzheimer's disease and tauopathies.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10887173
    review:
      summary: >-
        Documents interaction between YWHAZ and vimentin. Phosphorylated vimentin
        can sequester 14-3-3 proteins, demonstrating phosphorylation-dependent binding.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction showing 14-3-3 binding to phosphorylated
        intermediate filament protein.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11237865
    review:
      summary: >-
        Documents interaction between YWHAZ and FKHR (FOXO1). Demonstrates that 14-3-3
        binding to phosphorylated FOXO1 regulates its nuclear localization and
        transcriptional activity.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction. FOXO transcription factors are core 14-3-3
        clients whose nuclear/cytoplasmic localization is controlled by 14-3-3 binding.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11336675
    review:
      summary: >-
        Crystal structure of YWHAZ bound to AANAT (serotonin N-acetyltransferase).
        This landmark structural study revealed how 14-3-3 proteins scaffold enzymes
        in a phosphorylation-dependent manner to modulate their activity.
      action: ACCEPT
      reason: >-
        Valid and important structural interaction study. AANAT is a key 14-3-3 client
        in melatonin synthesis pathway. The crystal structure provided fundamental
        insights into 14-3-3 scaffold function.
      supported_by:
        - reference_id: PMID:11336675
          supporting_text: >-
            AANAT is bound in the central channel of the 14-3-3zeta dimer, and is
            held in place by extensive interactions both with the amphipathic
            phosphopeptide binding groove of 14-3-3zeta and with other parts of
            the central channel.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11504882
    review:
      summary: >-
        Documents interaction between YWHAZ and HDAC4. 14-3-3 binding to phosphorylated
        class IIa HDACs regulates their nuclear/cytoplasmic shuttling.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction. Class IIa HDACs (HDAC4, 5, 7, 9) are
        well-established 14-3-3 clients whose localization is regulated by
        phosphorylation-dependent 14-3-3 binding.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11526496
    review:
      summary: >-
        Documents interaction between YWHAZ and BAD. 14-3-3 binding to phosphorylated
        BAD sequesters it in the cytoplasm and prevents apoptosis.
      action: ACCEPT
      reason: >-
        Valid protein-protein interaction. BAD is a canonical 14-3-3 client whose
        cytoplasmic sequestration by 14-3-3 prevents mitochondrial translocation
        and blocks apoptosis. Deep research confirms this interaction.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11697890
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:11697890
          supporting_text: Functional conservation of 14-3-3 isoforms in 
            inhibiting bad-induced apoptosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11723239
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:11723239
          supporting_text: 14-3-3 inhibits Bad-induced cell death through 
            interaction with serine-136.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11864996
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:11864996
          supporting_text: Feb 25. 14-3-3 transits to the nucleus and 
            participates in dynamic nucleocytoplasmic transport.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12154078
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12154078
          supporting_text: Regulation of the CDK-related protein kinase 
            PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A 
            cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12176984
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12176984
          supporting_text: 2002 Aug 9. Identification and characterization of 
            the interaction between tuberin and 14-3-3zeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12361576
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12361576
          supporting_text: 14-3-3 regulates actin dynamics by stabilizing 
            phosphorylated cofilin.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12383250
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12383250
          supporting_text: A nonphosphorylated 14-3-3 binding motif on exoenzyme
            S that is functional in vivo.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12438239
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12438239
          supporting_text: 14-3-3 interacts with the tumor suppressor tuberin at
            Akt phosphorylation site(s).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12468542
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12468542
          supporting_text: 2002 Dec 4. 14-3-3beta binds to and negatively 
            regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor 
            gene product, tuberin.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12589811
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12589811
          supporting_text: 'The interaction between ADAM 22 and 14-3-3zeta: regulation
            of cell adhesion and spreading.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12615066
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12615066
          supporting_text: Characterization of zetin 1/rBSPRY, a novel binding 
            partner of 14-3-3 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12757707
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12757707
          supporting_text: Interaction of Akt-phosphorylated ataxin-1 with 
            14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12764136
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12764136
          supporting_text: 2003 May 22. 14-3-3 acts as an intramolecular bridge 
            to regulate cdc25B localization and activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12766774
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12766774
          supporting_text: Dual phosphorylation controls Cdc25 phosphatases and 
            mitotic entry.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12819209
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12819209
          supporting_text: 2003 Jun 20. Threonine 391 phosphorylation of the 
            human prolactin receptor mediates a novel interaction with 14-3-3 
            proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12941695
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12941695
          supporting_text: Functional analysis of C-TAK1 substrate binding and 
            identification of PKP2 as a new C-TAK1 substrate.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12944463
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12944463
          supporting_text: Protein phosphatase 2A dephosphorylation of 
            phosphoserine 112 plays the gatekeeper role for BAD-mediated 
            apoptosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12963375
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12963375
          supporting_text: 'Alternative splicing as a mechanism for regulating 14-3-3
            binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14676191
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:14676191
          supporting_text: 2003 Dec 15. Comprehensive proteomic analysis of 
            human Par protein complexes reveals an interconnected protein 
            network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14688280
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:14688280
          supporting_text: '2003 Dec 19. Dynamic changes in C-Raf phosphorylation
            and 14-3-3 protein binding in response to growth factor stimulation: differential
            roles of 14-3-3 protein binding sites.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14743216
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:14743216
          supporting_text: A physical and functional map of the human 
            TNF-alpha/NF-kappa B signal transduction pathway.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:14970201
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:14970201
          supporting_text: 2004 Feb 17. p21-activated kinase 1 phosphorylates 
            and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho 
            exchange factor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15023544
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15023544
          supporting_text: Interaction of apoptosis signal-regulating kinase 1 
            with isoforms of 14-3-3 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15037601
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15037601
          supporting_text: Mar 22. YSK1 is activated by the Golgi matrix protein
            GM130 and plays a role in cell migration through its substrate 
            14-3-3zeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15161933
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15161933
          supporting_text: 2004 May 25. Comprehensive proteomic analysis of 
            interphase and mitotic 14-3-3-binding proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15225635
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15225635
          supporting_text: Identification of 14-3-3zeta as an EGF receptor 
            interacting protein.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15314064
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15314064
          supporting_text: Raf-1 activation disrupts its binding to keratins 
            during cell stress.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15324659
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15324659
          supporting_text: aPKC acts upstream of PAR-1b in both the 
            establishment and maintenance of mammalian epithelial polarity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15324660
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15324660
          supporting_text: Proteomic, functional, and domain-based analysis of 
            in vivo 14-3-3 binding proteins involved in cytoskeletal regulation 
            and cellular organization.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15629715
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15629715
          supporting_text: MAPKAP kinase-2 is a cell cycle checkpoint kinase 
            that regulates the G2/M transition and S phase progression in 
            response to UV irradiation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15657067
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15657067
          supporting_text: Epub 2005 Jan 17. Phosphotyrosine signaling networks 
            in epidermal growth factor receptor overexpressing squamous 
            carcinoma cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15696159
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15696159
          supporting_text: JNK phosphorylation of 14-3-3 proteins regulates 
            nuclear targeting of c-Abl in the apoptotic response to DNA damage.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15964851
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:15964851
          supporting_text: 2005 Jun 17. Identification of the ankyrin repeat 
            proteins ANKRA and RFXANK as novel partners of class IIa histone 
            deacetylases.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16246723
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16246723
          supporting_text: Molecular basis for the recognition of phosphorylated
            and phosphoacetylated histone h3 by 14-3-3.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16306228
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16306228
          supporting_text: 14-3-3 cooperates with LKB1 to regulate the activity 
            and localization of QSK and SIK.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16376338
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16376338
          supporting_text: 2005 Dec 19. Protein kinase A phosphorylates and 
            regulates dimerization of 14-3-3 epsilon.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16449798
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16449798
          supporting_text: Thioredoxin-ASK1 complex levels regulate ROS-mediated
            p38 MAPK pathway activity in livers of aged and long-lived Snell 
            dwarf mice.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16511560
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16511560
          supporting_text: Mar 2. Regulation of MDMX nuclear import and 
            degradation by Chk2 and 14-3-3.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16636147
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16636147
          supporting_text: Activity of TSC2 is inhibited by AKT-mediated 
            phosphorylation and membrane partitioning.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16672277
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16672277
          supporting_text: Amino acids C-terminal to the 14-3-3 binding motif in
            CDC25B affect the efficiency of 14-3-3 binding.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16868027
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16868027
          supporting_text: Jul 25. Efficient ADAM22 surface expression is 
            mediated by phosphorylation-dependent interaction with 14-3-3 
            protein family members.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16959763
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16959763
          supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics 
            identifies new 14-3-3-associated proteins involved in cytoskeletal 
            rearrangements and cell signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17043677
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:17043677
          supporting_text: 'Oct 17. Disrupted in Schizophrenia 1 Interactome: evidence
            for the close connectivity of risk genes and a potential synaptic basis
            for schizophrenia.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17166838
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:17166838
          supporting_text: 2006 Dec 13. 14-3-3 protein interacts with 
            Huntingtin-associated protein 1 and regulates its trafficking.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17317006
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:17317006
          supporting_text: Epub 2007 Feb 3. 14-3-3zeta facilitates 
            GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a 
            mechanism that requires phosphorylation of GSK3beta on Ser9.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17353931
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:17353931
          supporting_text: Large-scale mapping of human protein-protein 
            interactions by mass spectrometry.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17979178
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:17979178
          supporting_text: A novel tandem affinity purification strategy for the
            efficient isolation and characterisation of native protein 
            complexes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18418070
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18418070
          supporting_text: Mar 11. Modulation of 14-3-3 interaction with 
            phosphorylated histone H3 by combinatorial modification patterns.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18573912
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18573912
          supporting_text: Jun 23. Chibby cooperates with 14-3-3 to regulate 
            beta-catenin subcellular distribution and signaling activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18647389
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18647389
          supporting_text: The central proline rich region of POB1/REPS2 plays a
            regulatory role in epidermal growth factor receptor endocytosis by 
            binding to 14-3-3 and SH3 domain-containing proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19049963
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19049963
          supporting_text: '2008 Dec 2. Regulation of RAF activity by 14-3-3 proteins:
            RAF kinases associate functionally with both homo- and heterodimeric forms
            of 14-3-3 proteins.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19138662
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19138662
          supporting_text: Effect of phosphorylation on interaction of human tau
            protein with 14-3-3zeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19357195
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19357195
          supporting_text: 2009 Apr 8. Shear stress induced reorganization of 
            the keratin intermediate filament network requires phosphorylation 
            by protein kinase C zeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19481529
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19481529
          supporting_text: Akt and 14-3-3 control a PACS-2 homeostatic switch 
            that integrates membrane traffic with TRAIL-induced apoptosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19647741
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19647741
          supporting_text: Epub 2009 Aug 3. Phosphorylation of more than one 
            site is required for tight interaction of human tau protein with 
            14-3-3zeta.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19662078
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19662078
          supporting_text: Recognition of an intra-chain tandem 14-3-3 binding 
            site within PKCepsilon.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19667065
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19667065
          supporting_text: 'Epub 2009 Aug 10. Identification of novel in vivo phosphorylation
            sites of the human proapoptotic protein BAD: pore-forming activity of
            BAD is regulated by phosphorylation.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19720745
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19720745
          supporting_text: Aug 31. Characterization of Rictor phosphorylation 
            sites reveals direct regulation of mTOR complex 2 by S6K1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19732720
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19732720
          supporting_text: 14-3-3zeta Cooperates with ErbB2 to promote ductal 
            carcinoma in situ progression to invasive breast cancer by inducing 
            epithelial-mesenchymal transition.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19766566
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19766566
          supporting_text: Histone crosstalk between H3S10ph and H4K16ac 
            generates a histone code that mediates transcription elongation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19860830
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19860830
          supporting_text: 2009 Oct 27. The interaction between casein kinase 
            Ialpha and 14-3-3 is phosphorylation dependent.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19933840
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19933840
          supporting_text: Regulation of IRSp53-dependent filopodial dynamics by
            antagonism between 14-3-3 binding and SH3-mediated localization.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19940019
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19940019
          supporting_text: 2009 Nov 25. Nuclear-cytoplasmic shuttling of Chibby 
            controls beta-catenin signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20037628
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20037628
          supporting_text: Phosphorylation of S776 and 14-3-3 binding modulate 
            ataxin-1 interaction with splicing factors.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20052757
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20052757
          supporting_text: 'Molecular and clinical analysis of RAF1 in Noonan syndrome
            and related disorders: dephosphorylation of serine 259 as the essential
            mechanism for mutant activation.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20224040
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20224040
          supporting_text: 2010 Mar 11. Histone deacetylase 7 controls 
            endothelial cell growth through modulation of beta-catenin.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20451386
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20451386
          supporting_text: 2010 May 6. Aurora B and 14-3-3 coordinately regulate
            clustering of centralspindlin during cytokinesis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20603015
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20603015
          supporting_text: Identification of KIAA1018/FAN1, a DNA repair 
            nuclease recruited to DNA damage by monoubiquitinated FANCD2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20618440
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20618440
          supporting_text: 2010 Jul 8. Proteomic and biochemical analysis of 
            14-3-3-binding proteins during C2-ceramide-induced apoptosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20642453
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20642453
          supporting_text: 14-3-3 binding to LRRK2 is disrupted by multiple 
            Parkinson's disease-associated mutations and regulates cytoplasmic 
            localization.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20679480
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20679480
          supporting_text: Aug 2. Impaired binding of 14-3-3 to C-RAF in Noonan 
            syndrome suggests new approaches in diseases with increased Ras 
            signaling.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20936779
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20936779
          supporting_text: A human MAP kinase interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21282530
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21282530
          supporting_text: Epub 2011 Jan 31. Interaction proteomics analysis of 
            polycomb proteins defines distinct PRC1 complexes in mammalian 
            cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21988832
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21988832
          supporting_text: Toward an understanding of the protein interaction 
            network of the human liver.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22575644
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:22575644
          supporting_text: 2012 Mar 23. 14-3-3 interacts with LKB1 via 
            recognizing phosphorylated threonine 336 residue and suppresses LKB1
            kinase function.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22580824
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:22580824
          supporting_text: ARF6 GTPase protects the post-mitotic midbody from 
            14-3-3-mediated disintegration.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22653443
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:22653443
          supporting_text: Mutant p53 interactome identifies nardilysin as a 
            p53R273H-specific binding partner that promotes invasion.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23075850
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23075850
          supporting_text: Progressive degeneration of human neural stem cells 
            caused by pathogenic LRRK2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23397142
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23397142
          supporting_text: Epub 2013 Feb 8. Analysis of protein-protein 
            interactions in cross-talk pathways reveals CRKL protein as a novel 
            prognostic marker in hepatocellular carcinoma.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23414517
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23414517
          supporting_text: 'A human skeletal muscle interactome centered on proteins
            involved in muscular dystrophies: LGMD interactome.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23455924
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23455924
          supporting_text: A Y2H-seq approach defines the human protein 
            methyltransferase interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23622247
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23622247
          supporting_text: 14-3-3 proteins interact with a hybrid 
            prenyl-phosphorylation motif to inhibit G proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23752268
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23752268
          supporting_text: The functional interactome landscape of the human 
            histone deacetylase family.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24255178
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:24255178
          supporting_text: Protein interaction network of the mammalian Hippo 
            pathway reveals mechanisms of kinase-phosphatase interactions.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24351927
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:24351927
          supporting_text: Parkinson-related LRRK2 mutation R1441C/G/H impairs 
            PKA phosphorylation of LRRK2 and disrupts its interaction with 
            14-3-3.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24510904
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:24510904
          supporting_text: Unbiased screen for interactors of leucine-rich 
            repeat kinase 2 supports a common pathway for sporadic and familial 
            Parkinson disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24658140
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:24658140
          supporting_text: The mammalian-membrane two-hybrid assay (MaMTH) for 
            probing membrane-protein interactions in human cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24947832
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:24947832
          supporting_text: Differential protein-protein interactions of LRRK1 
            and LRRK2 indicate roles in distinct cellular signaling pathways.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25277244
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25277244
          supporting_text: Epub 2014 Oct 2. The functional landscape of Hsp27 
            reveals new cellular processes such as DNA repair and alternative 
            splicing and proposes novel anticancer targets.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25670079
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25670079
          supporting_text: 14-3-3ζ turns TGF-β's function from tumor suppressor 
            to metastasis promoter in breast cancer by contextual changes of 
            Smad partners from p53 to Gli2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25852190
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25852190
          supporting_text: Integrative analysis of kinase networks in 
            TRAIL-induced apoptosis provides a source of potential targets for 
            combination therapy.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25959826
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25959826
          supporting_text: 2015 May 7. Quantitative interaction proteomics of 
            neurodegenerative disease proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26496610
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:26496610
          supporting_text: Oct 22. A human interactome in three quantitative 
            dimensions organized by stoichiometries and abundances.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27291054
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:27291054
          supporting_text: 2016 Jun 9. Isolation of Functional Tubulin Dimers 
            and of Tubulin-Associated Proteins from Mammalian Cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27880917
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:27880917
          supporting_text: Phenotypic and Interaction Profiling of the Human 
            Phosphatases Identifies Diverse Mitotic Regulators.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28330616
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:28330616
          supporting_text: 2017 Mar 18. Systematic Analysis of Human Protein 
            Phosphatase Interactions and Dynamics.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28514442
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:28514442
          supporting_text: Architecture of the human interactome defines protein
            communities and disease networks.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:28575131
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:28575131
          supporting_text: eCollection 2017. Bacterial co-expression of human 
            Tau protein with protein kinase A and 14-3-3 for studies of 
            14-3-3/phospho-Tau interaction.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:29100370
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:29100370
          supporting_text: eCollection 2017 Sep 29.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:29408703
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:29408703
          supporting_text: 2018 Feb 1. Structural characterization of 14-3-3ζ in
            complex with the human Son of sevenless homolog 1 (SOS1).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31046837
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31046837
          supporting_text: Parkinson's disease-associated LRRK2-G2019S mutant 
            acts through regulation of SERCA activity to control ER stress in 
            astrocytes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31413325
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31413325
          supporting_text: HENA, heterogeneous network-based data set for 
            Alzheimer's disease.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31980649
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31980649
          supporting_text: Extensive rewiring of the EGFR network in colorectal 
            cancer cells expressing transforming levels of KRAS(G13D).
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32707033
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:32707033
          supporting_text: 2020 Jul 23. Kinase Interaction Network Expands 
            Functional and Disease Roles of Human Kinases.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:33961781
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:33961781
          supporting_text: 2021 May 6. Dual proteome-scale networks reveal 
            cell-specific remodeling of the human interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:34927784
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:34927784
          supporting_text: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase 
            activator that is downregulated in breast cancer.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35271311
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35271311
          supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography
            of human cellular organization.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:35512704
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35512704
          supporting_text: 2022 May 4. Systematic discovery of mutation-directed
            neo-protein-protein interactions in cancer.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:36096339
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:36096339
          supporting_text: Sep 9. Cytosolic sequestration of spatacsin by 
            Protein Kinase A and 14-3-3 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:36931259
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:36931259
          supporting_text: A central chaperone-like role for 14-3-3 proteins in 
            human cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:37045861
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:37045861
          supporting_text: Interactome dynamics of RAF1-BRAF kinase monomers and
            dimers.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:37776851
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:37776851
          supporting_text: 2023 Sep 29. Analysis of proteome-wide degradation 
            dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted 
            VCP homeostasis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:39251607
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:39251607
          supporting_text: Systematic identification of post-transcriptional 
            regulatory modules.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:40205054
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:40205054
          supporting_text: Apr 9. Multimodal cell maps as a foundation for 
            structural and functional genomics.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7935795
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:7935795
          supporting_text: Activation of Raf-1 by 14-3-3 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7939632
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:7939632
          supporting_text: Interaction of the protein kinase Raf-1 with 14-3-3 
            proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8085158
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:8085158
          supporting_text: Binding of 14-3-3 proteins to the protein kinase Raf 
            and effects on its activation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8601312
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:8601312
          supporting_text: Interaction of 14-3-3 with signaling proteins is 
            mediated by the recognition of phosphoserine.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9153224
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:9153224
          supporting_text: Raf-1 kinase and exoenzyme S interact with 14-3-3zeta
            through a common site involving lysine 49.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:16376338
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16376338
          supporting_text: 2005 Dec 19. Protein kinase A phosphorylates and 
            regulates dimerization of 14-3-3 epsilon.
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IPI
    original_reference_id: PMID:20618440
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20618440
          supporting_text: 2010 Jul 8. Proteomic and biochemical analysis of 
            14-3-3-binding proteins during C2-ceramide-induced apoptosis.
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0003016
      label: respiratory system process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0008039
      label: synaptic target recognition
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0019904
      label: protein domain specific binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0030324
      label: lung development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0035148
      label: tube formation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0098686
      label: hippocampal mossy fiber to CA3 synapse
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:21621563
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21621563
          supporting_text: Bimodal regulation of FoxO3 by AKT and 14-3-3.
  - term:
      id: GO:0019903
      label: protein phosphatase binding
    evidence_type: IPI
    original_reference_id: PMID:9543386
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:9543386
          supporting_text: C-TAK1 protein kinase phosphorylates human Cdc25C on 
            serine 216 and promotes 14-3-3 protein binding.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:31906564
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31906564
          supporting_text: Differential Subcellular Distribution and 
            Translocation of Seven 14-3-3 Isoforms in Response to EGF and During
            the Cell Cycle.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:31906564
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31906564
          supporting_text: Differential Subcellular Distribution and 
            Translocation of Seven 14-3-3 Isoforms in Response to EGF and During
            the Cell Cycle.
  - term:
      id: GO:0090128
      label: regulation of synapse maturation
    evidence_type: IDA
    original_reference_id: PMID:16959763
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16959763
          supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics 
            identifies new 14-3-3-associated proteins involved in cytoskeletal 
            rearrangements and cell signaling.
  - term:
      id: GO:0090128
      label: regulation of synapse maturation
    evidence_type: IMP
    original_reference_id: PMID:16959763
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16959763
          supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics 
            identifies new 14-3-3-associated proteins involved in cytoskeletal 
            rearrangements and cell signaling.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IDA
    original_reference_id: PMID:16959763
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16959763
          supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics 
            identifies new 14-3-3-associated proteins involved in cytoskeletal 
            rearrangements and cell signaling.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IMP
    original_reference_id: PMID:16959763
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16959763
          supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics 
            identifies new 14-3-3-associated proteins involved in cytoskeletal 
            rearrangements and cell signaling.
  - term:
      id: GO:0044325
      label: transmembrane transporter binding
    evidence_type: IPI
    original_reference_id: PMID:18029012
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18029012
          supporting_text: 2007 Oct 29. Inhibitory interaction of the 14-3-3 
            proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) 
            isoforms of the plasma membrane Ca2+ pump.
  - term:
      id: GO:1900181
      label: negative regulation of protein localization to nucleus
    evidence_type: IDA
    original_reference_id: PMID:35662396
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35662396
          supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer 
            that promotes antibacterial innate immunity.
  - term:
      id: GO:0042149
      label: cellular response to glucose starvation
    evidence_type: IDA
    original_reference_id: PMID:18439900
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18439900
          supporting_text: AMPK phosphorylation of raptor mediates a metabolic 
            checkpoint.
  - term:
      id: GO:0140311
      label: protein sequestering activity
    evidence_type: IDA
    original_reference_id: PMID:18439900
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18439900
          supporting_text: AMPK phosphorylation of raptor mediates a metabolic 
            checkpoint.
  - term:
      id: GO:1904262
      label: negative regulation of TORC1 signaling
    evidence_type: IDA
    original_reference_id: PMID:18439900
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:18439900
          supporting_text: AMPK phosphorylation of raptor mediates a metabolic 
            checkpoint.
  - term:
      id: GO:0045824
      label: negative regulation of innate immune response
    evidence_type: IDA
    original_reference_id: PMID:35662396
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35662396
          supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer 
            that promotes antibacterial innate immunity.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: PMID:35662396
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35662396
          supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer 
            that promotes antibacterial innate immunity.
  - term:
      id: GO:0050815
      label: phosphoserine residue binding
    evidence_type: IDA
    original_reference_id: PMID:35662396
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35662396
          supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer 
            that promotes antibacterial innate immunity.
  - term:
      id: GO:0140311
      label: protein sequestering activity
    evidence_type: IDA
    original_reference_id: PMID:35662396
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:35662396
          supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer 
            that promotes antibacterial innate immunity.
  - term:
      id: GO:0031647
      label: regulation of protein stability
    evidence_type: EXP
    original_reference_id: PMID:21554249
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21554249
          supporting_text: 'NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal
            extension: differentiation of the chaperone and phosphoserine-binding
            activities of 14-3-3ζ.'
  - term:
      id: GO:0140297
      label: DNA-binding transcription factor binding
    evidence_type: IPI
    original_reference_id: PMID:16114898
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16114898
          supporting_text: 14-3-3 Protein interacts with nuclear localization 
            sequence of forkhead transcription factor FoxO4.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27030597
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:27030597
          supporting_text: Familial autoinflammation with neutrophilic 
            dermatosis reveals a regulatory mechanism of pyrin activation.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:31024343
    review:
      summary: >-
        OVER-ANNOTATION: YWHAZ is a 14-3-3 scaffold protein that REGULATES kinase
        activity but does not perform phosphorylation itself. PMID:31024343 shows
        YWHAZ "enhances Raf-stimulated Erk phosphorylation" - RAF is the kinase that
        performs the phosphorylation, YWHAZ is a scaffold that modulates RAF activity.
        14-3-3 proteins bind phosphorylated proteins and regulate signaling pathways
        but have no kinase activity. Already correctly annotated to GO:0043405
        "regulation of MAP kinase activity".
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:31024343
          supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous 
            Syndrome Activates the RAF-ERK Pathway.
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IMP
    original_reference_id: PMID:31024343
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31024343
          supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous 
            Syndrome Activates the RAF-ERK Pathway.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:31024343
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31024343
          supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous 
            Syndrome Activates the RAF-ERK Pathway.
  - term:
      id: GO:0070372
      label: regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:31024343
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:31024343
          supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous 
            Syndrome Activates the RAF-ERK Pathway.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25189701
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25189701
          supporting_text: Sep 4. A quantitative 14-3-3 interaction screen 
            connects the nuclear exosome targeting complex to the DNA damage 
            response.
  - term:
      id: GO:0045296
      label: cadherin binding
    evidence_type: HDA
    original_reference_id: PMID:25468996
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:25468996
          supporting_text: E-cadherin interactome complexity and robustness 
            resolved by quantitative proteomics.
  - term:
      id: GO:0031982
      label: vesicle
    evidence_type: HDA
    original_reference_id: PMID:19190083
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19190083
          supporting_text: 'Characterization of exosome-like vesicles released from
            human tracheobronchial ciliated epithelium: a possible role in innate
            defense.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21182262
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21182262
          supporting_text: 'Structural characterization of partially disordered human
            Chibby: insights into its function in the Wnt-signaling pathway.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23572552
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23572552
          supporting_text: ACBD3 interaction with TBC1 domain 22 protein is 
            differentially affected by enteroviral and kobuviral 3A protein 
            binding.
  - term:
      id: GO:0031625
      label: ubiquitin protein ligase binding
    evidence_type: IPI
    original_reference_id: PMID:19725078
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19725078
          supporting_text: Proteomic analysis of increased Parkin expression and
            its interactants provides evidence for a role in modulation of 
            mitochondrial function.
  - term:
      id: GO:0090168
      label: Golgi reassembly
    evidence_type: IMP
    original_reference_id: PMID:20332113
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20332113
          supporting_text: Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to 
            promote Golgi assembly and cell orientation.
  - term:
      id: GO:0051683
      label: establishment of Golgi localization
    evidence_type: IMP
    original_reference_id: PMID:20332113
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20332113
          supporting_text: Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to 
            promote Golgi assembly and cell orientation.
  - term:
      id: GO:0005925
      label: focal adhesion
    evidence_type: HDA
    original_reference_id: PMID:21423176
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21423176
          supporting_text: Analysis of the myosin-II-responsive focal adhesion 
            proteome reveals a role for β-Pix in negative regulation of focal 
            adhesion maturation.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:23533145
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23533145
          supporting_text: 2013 Apr 23. In-depth proteomic analyses of exosomes 
            isolated from expressed prostatic secretions in urine.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: HDA
    original_reference_id: PMID:16502470
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16502470
          supporting_text: 'Human colostrum: identification of minor proteins in the
            aqueous phase by proteomics.'
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: HDA
    original_reference_id: PMID:21630459
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21630459
          supporting_text: Jun 1. Proteomic characterization of the human sperm 
            nucleus.
  - term:
      id: GO:0003723
      label: RNA binding
    evidence_type: HDA
    original_reference_id: PMID:22658674
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:22658674
          supporting_text: May 31. Insights into RNA biology from an atlas of 
            mammalian mRNA-binding proteins.
  - term:
      id: GO:0072562
      label: blood microparticle
    evidence_type: HDA
    original_reference_id: PMID:22516433
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:22516433
          supporting_text: Epub 2012 Apr 10. Proteomic analysis of microvesicles
            from plasma of healthy donors reveals high individual variability.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: HDA
    original_reference_id: PMID:23580065
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:23580065
          supporting_text: Shotgun proteomics reveals specific modulated protein
            patterns in tears of patients with primary open angle glaucoma naïve
            to therapy.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:19199708
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19199708
          supporting_text: Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT).
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:19056867
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19056867
          supporting_text: 2008 Dec 3. Large-scale proteomics and 
            phosphoproteomics of urinary exosomes.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:20458337
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:20458337
          supporting_text: 2010 May 11. MHC class II-associated proteins in 
            B-cell exosomes and potential functional implications for exosome 
            biogenesis.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3769391
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3769392
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3769393
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-450620
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-139899
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-139906
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-3769392
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-430073
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-430076
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-443402
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-443831
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5632732
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-5632738
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-75016
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-912757
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-913993
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-914182
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9614423
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9614562
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9614564
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9727919
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-9729500
    review:
      summary: >-
        Annotation based on automated or curated evidence. YWHAZ is a 14-3-3 adapter
        protein with documented roles in this process/location based on its interactions
        with client proteins.
      action: ACCEPT
      reason: >-
        Valid annotation consistent with YWHAZ function as an adapter protein involved
        in regulating localization and activity of phosphorylated client proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:10102273
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:10102273
          supporting_text: Akt promotes cell survival by phosphorylating and 
            inhibiting a Forkhead transcription factor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10026197
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:10026197
          supporting_text: Cell adhesion regulates the interaction between the 
            docking protein p130(Cas) and the 14-3-3 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12176995
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:12176995
          supporting_text: 2002 Aug 9. MADM, a novel adaptor protein that 
            mediates phosphorylation of the 14-3-3 binding site of myeloid 
            leukemia factor 1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21081150
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:21081150
          supporting_text: Pore-forming activity of BAD is regulated by specific
            phosphorylation and structural transitions of the C-terminal part.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19172738
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:19172738
          supporting_text: Phosphorylation-dependent binding of 14-3-3 
            terminates signalling by the Gab2 docking protein.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: TAS
    original_reference_id: PMID:16130169
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16130169
          supporting_text: Proteomics of human umbilical vein endothelial cells 
            applied to etoposide-induced apoptosis.
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: TAS
    original_reference_id: PMID:16130169
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16130169
          supporting_text: Proteomics of human umbilical vein endothelial cells 
            applied to etoposide-induced apoptosis.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: TAS
    original_reference_id: PMID:16130169
    review:
      summary: >-
        Documents protein-protein interaction involving YWHAZ. As a 14-3-3 adapter
        protein, YWHAZ binds hundreds of phosphorylated client proteins. While the
        term "protein binding" is generic, it correctly captures the physical interaction
        evidence documented in this study.
      action: ACCEPT
      reason: >-
        Valid IPI evidence documenting a protein-protein interaction. YWHAZ is an
        adapter protein whose core function is binding phosphorylated proteins.
        The deep research documents extensive interactome of 14-3-3 proteins.
      additional_reference_ids:
        - file:human/YWHAZ/YWHAZ-deep-research-falcon.md
      supported_by:
        - reference_id: PMID:16130169
          supporting_text: Proteomics of human umbilical vein endothelial cells
            applied to etoposide-induced apoptosis.
core_functions:
  - molecular_function:
      id: GO:0042802
      label: identical protein binding
    description: >-
      YWHAZ forms homodimers as obligate functional units. The dimeric W-shaped
      architecture presents two peptide-binding grooves that can simultaneously
      engage two phosphomotifs, either on the same client or bridging two clients.
      Homodimerization is regulated by phosphorylation at Ser-58.
    directly_involved_in:
      - id: GO:0008104
        label: intracellular protein localization
      - id: GO:0007165
        label: signal transduction
    locations:
      - id: GO:0005737
        label: cytoplasm
references:
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: PMID:10026197
    title: Cell adhesion regulates the interaction between the docking protein 
      p130(Cas) and the 14-3-3 proteins.
    findings: []
  - id: PMID:10102273
    title: Akt promotes cell survival by phosphorylating and inhibiting a 
      Forkhead transcription factor.
    findings: []
  - id: PMID:10642536
    title: 14-3-3zeta interacts with the alpha-chain of human interleukin 9 
      receptor.
    findings: []
  - id: PMID:10713667
    title: Specific interaction between 14-3-3 isoforms and the human CDC25B 
      phosphatase.
    findings: []
  - id: PMID:10840038
    title: 14-3-3zeta is an effector of tau protein phosphorylation.
    findings: []
  - id: PMID:10887173
    title: Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and 
      displaces other 14-3-3 partners in vivo.
    findings: []
  - id: PMID:11237865
    title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation 
      sites in regulating 14-3-3 binding, transactivation and nuclear 
      targetting.
    findings: []
  - id: PMID:11336675
    title: Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase 
      complex. a role for scaffolding in enzyme regulation.
    findings: []
  - id: PMID:11504882
    title: Differential localization of HDAC4 orchestrates muscle 
      differentiation.
    findings: []
  - id: PMID:11526496
    title: The growth-promoting activity of the Bad protein in chicken embryo 
      fibroblasts requires binding to protein 14-3-3.
    findings: []
  - id: PMID:11697890
    title: Functional conservation of 14-3-3 isoforms in inhibiting bad-induced 
      apoptosis.
    findings: []
  - id: PMID:11723239
    title: 14-3-3 inhibits Bad-induced cell death through interaction with 
      serine-136.
    findings: []
  - id: PMID:11864996
    title: 14-3-3 transits to the nucleus and participates in dynamic 
      nucleocytoplasmic transport.
    findings: []
  - id: PMID:12154078
    title: Regulation of the CDK-related protein kinase PCTAIRE-1 and its 
      possible role in neurite outgrowth in Neuro-2A cells.
    findings: []
  - id: PMID:12176984
    title: Identification and characterization of the interaction between 
      tuberin and 14-3-3zeta.
    findings: []
  - id: PMID:12176995
    title: MADM, a novel adaptor protein that mediates phosphorylation of the 
      14-3-3 binding site of myeloid leukemia factor 1.
    findings: []
  - id: PMID:12361576
    title: 14-3-3 regulates actin dynamics by stabilizing phosphorylated 
      cofilin.
    findings: []
  - id: PMID:12383250
    title: A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is 
      functional in vivo.
    findings: []
  - id: PMID:12438239
    title: 14-3-3 interacts with the tumor suppressor tuberin at Akt 
      phosphorylation site(s).
    findings: []
  - id: PMID:12468542
    title: 14-3-3beta binds to and negatively regulates the tuberous sclerosis 
      complex 2 (TSC2) tumor suppressor gene product, tuberin.
    findings: []
  - id: PMID:12589811
    title: 'The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion
      and spreading.'
    findings: []
  - id: PMID:12615066
    title: Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3
      proteins.
    findings: []
  - id: PMID:12757707
    title: Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates 
      neurodegeneration in spinocerebellar ataxia type 1.
    findings: []
  - id: PMID:12764136
    title: 14-3-3 acts as an intramolecular bridge to regulate cdc25B 
      localization and activity.
    findings: []
  - id: PMID:12766774
    title: Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
    findings: []
  - id: PMID:12819209
    title: Threonine 391 phosphorylation of the human prolactin receptor 
      mediates a novel interaction with 14-3-3 proteins.
    findings: []
  - id: PMID:12941695
    title: Functional analysis of C-TAK1 substrate binding and identification of
      PKP2 as a new C-TAK1 substrate.
    findings: []
  - id: PMID:12944463
    title: Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays 
      the gatekeeper role for BAD-mediated apoptosis.
    findings: []
  - id: PMID:12963375
    title: 'Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions
      between hD53 (TPD52L1) and 14-3-3 proteins.'
    findings: []
  - id: PMID:14676191
    title: Comprehensive proteomic analysis of human Par protein complexes 
      reveals an interconnected protein network.
    findings: []
  - id: PMID:14688280
    title: 'Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in
      response to growth factor stimulation: differential roles of 14-3-3 protein
      binding sites.'
    findings: []
  - id: PMID:14743216
    title: A physical and functional map of the human TNF-alpha/NF-kappa B 
      signal transduction pathway.
    findings: []
  - id: PMID:14970201
    title: p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to
      GEF-H1, a microtubule-localized Rho exchange factor.
    findings: []
  - id: PMID:15023544
    title: Interaction of apoptosis signal-regulating kinase 1 with isoforms of 
      14-3-3 proteins.
    findings: []
  - id: PMID:15037601
    title: YSK1 is activated by the Golgi matrix protein GM130 and plays a role 
      in cell migration through its substrate 14-3-3zeta.
    findings: []
  - id: PMID:15161933
    title: Comprehensive proteomic analysis of interphase and mitotic 
      14-3-3-binding proteins.
    findings: []
  - id: PMID:15225635
    title: Identification of 14-3-3zeta as an EGF receptor interacting protein.
    findings: []
  - id: PMID:15314064
    title: Raf-1 activation disrupts its binding to keratins during cell stress.
    findings: []
  - id: PMID:15324659
    title: aPKC acts upstream of PAR-1b in both the establishment and 
      maintenance of mammalian epithelial polarity.
    findings: []
  - id: PMID:15324660
    title: Proteomic, functional, and domain-based analysis of in vivo 14-3-3 
      binding proteins involved in cytoskeletal regulation and cellular 
      organization.
    findings: []
  - id: PMID:15629715
    title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the 
      G2/M transition and S phase progression in response to UV irradiation.
    findings: []
  - id: PMID:15657067
    title: Phosphotyrosine signaling networks in epidermal growth factor 
      receptor overexpressing squamous carcinoma cells.
    findings: []
  - id: PMID:15696159
    title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of
      c-Abl in the apoptotic response to DNA damage.
    findings: []
  - id: PMID:15964851
    title: Identification of the ankyrin repeat proteins ANKRA and RFXANK as 
      novel partners of class IIa histone deacetylases.
    findings: []
  - id: PMID:16114898
    title: 14-3-3 Protein interacts with nuclear localization sequence of 
      forkhead transcription factor FoxO4.
    findings: []
  - id: PMID:16130169
    title: Proteomics of human umbilical vein endothelial cells applied to 
      etoposide-induced apoptosis.
    findings: []
  - id: PMID:16246723
    title: Molecular basis for the recognition of phosphorylated and 
      phosphoacetylated histone h3 by 14-3-3.
    findings: []
  - id: PMID:16306228
    title: 14-3-3 cooperates with LKB1 to regulate the activity and localization
      of QSK and SIK.
    findings: []
  - id: PMID:16376338
    title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 
      epsilon.
    findings: []
  - id: PMID:16449798
    title: Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK 
      pathway activity in livers of aged and long-lived Snell dwarf mice.
    findings: []
  - id: PMID:16502470
    title: 'Human colostrum: identification of minor proteins in the aqueous phase
      by proteomics.'
    findings: []
  - id: PMID:16511560
    title: Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
    findings: []
  - id: PMID:16636147
    title: Activity of TSC2 is inhibited by AKT-mediated phosphorylation and 
      membrane partitioning.
    findings: []
  - id: PMID:16672277
    title: Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect 
      the efficiency of 14-3-3 binding.
    findings: []
  - id: PMID:16868027
    title: Efficient ADAM22 surface expression is mediated by 
      phosphorylation-dependent interaction with 14-3-3 protein family members.
    findings: []
  - id: PMID:16959763
    title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins
      involved in cytoskeletal rearrangements and cell signaling.
    findings: []
  - id: PMID:17043677
    title: 'Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity
      of risk genes and a potential synaptic basis for schizophrenia.'
    findings: []
  - id: PMID:17166838
    title: 14-3-3 protein interacts with Huntingtin-associated protein 1 and 
      regulates its trafficking.
    findings: []
  - id: PMID:17317006
    title: 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in 
      HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on 
      Ser9.
    findings: []
  - id: PMID:17353931
    title: Large-scale mapping of human protein-protein interactions by mass 
      spectrometry.
    findings: []
  - id: PMID:17979178
    title: A novel tandem affinity purification strategy for the efficient 
      isolation and characterisation of native protein complexes.
    findings: []
  - id: PMID:18029012
    title: Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1)
      and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.
    findings: []
  - id: PMID:18418070
    title: Modulation of 14-3-3 interaction with phosphorylated histone H3 by 
      combinatorial modification patterns.
    findings: []
  - id: PMID:18439900
    title: AMPK phosphorylation of raptor mediates a metabolic checkpoint.
    findings: []
  - id: PMID:18573912
    title: Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular 
      distribution and signaling activity.
    findings: []
  - id: PMID:18647389
    title: The central proline rich region of POB1/REPS2 plays a regulatory role
      in epidermal growth factor receptor endocytosis by binding to 14-3-3 and 
      SH3 domain-containing proteins.
    findings: []
  - id: PMID:19049963
    title: 'Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally
      with both homo- and heterodimeric forms of 14-3-3 proteins.'
    findings: []
  - id: PMID:19056867
    title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
    findings: []
  - id: PMID:19138662
    title: Effect of phosphorylation on interaction of human tau protein with 
      14-3-3zeta.
    findings: []
  - id: PMID:19172738
    title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by 
      the Gab2 docking protein.
    findings: []
  - id: PMID:19190083
    title: 'Characterization of exosome-like vesicles released from human tracheobronchial
      ciliated epithelium: a possible role in innate defense.'
    findings: []
  - id: PMID:19199708
    title: Proteomic analysis of human parotid gland exosomes by 
      multidimensional protein identification technology (MudPIT).
    findings: []
  - id: PMID:19357195
    title: Shear stress induced reorganization of the keratin intermediate 
      filament network requires phosphorylation by protein kinase C zeta.
    findings: []
  - id: PMID:19481529
    title: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates 
      membrane traffic with TRAIL-induced apoptosis.
    findings: []
  - id: PMID:19647741
    title: Phosphorylation of more than one site is required for tight 
      interaction of human tau protein with 14-3-3zeta.
    findings: []
  - id: PMID:19662078
    title: Recognition of an intra-chain tandem 14-3-3 binding site within 
      PKCepsilon.
    findings: []
  - id: PMID:19667065
    title: 'Identification of novel in vivo phosphorylation sites of the human proapoptotic
      protein BAD: pore-forming activity of BAD is regulated by phosphorylation.'
    findings: []
  - id: PMID:19720745
    title: Characterization of Rictor phosphorylation sites reveals direct 
      regulation of mTOR complex 2 by S6K1.
    findings: []
  - id: PMID:19725078
    title: Proteomic analysis of increased Parkin expression and its 
      interactants provides evidence for a role in modulation of mitochondrial 
      function.
    findings: []
  - id: PMID:19732720
    title: 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ 
      progression to invasive breast cancer by inducing epithelial-mesenchymal 
      transition.
    findings: []
  - id: PMID:19766566
    title: Histone crosstalk between H3S10ph and H4K16ac generates a histone 
      code that mediates transcription elongation.
    findings: []
  - id: PMID:19860830
    title: The interaction between casein kinase Ialpha and 14-3-3 is 
      phosphorylation dependent.
    findings: []
  - id: PMID:19933840
    title: Regulation of IRSp53-dependent filopodial dynamics by antagonism 
      between 14-3-3 binding and SH3-mediated localization.
    findings: []
  - id: PMID:19940019
    title: Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin 
      signaling.
    findings: []
  - id: PMID:20037628
    title: Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 
      interaction with splicing factors.
    findings: []
  - id: PMID:20052757
    title: 'Molecular and clinical analysis of RAF1 in Noonan syndrome and related
      disorders: dephosphorylation of serine 259 as the essential mechanism for mutant
      activation.'
    findings: []
  - id: PMID:20224040
    title: Histone deacetylase 7 controls endothelial cell growth through 
      modulation of beta-catenin.
    findings: []
  - id: PMID:20332113
    title: CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and 
      cell orientation.
    findings: []
  - id: PMID:20451386
    title: Aurora B and 14-3-3 coordinately regulate clustering of 
      centralspindlin during cytokinesis.
    findings: []
  - id: PMID:20458337
    title: MHC class II-associated proteins in B-cell exosomes and potential 
      functional implications for exosome biogenesis.
    findings: []
  - id: PMID:20603015
    title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to 
      DNA damage by monoubiquitinated FANCD2.
    findings: []
  - id: PMID:20618440
    title: Proteomic and biochemical analysis of 14-3-3-binding proteins during 
      C2-ceramide-induced apoptosis.
    findings: []
  - id: PMID:20642453
    title: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's 
      disease-associated mutations and regulates cytoplasmic localization.
    findings: []
  - id: PMID:20679480
    title: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new 
      approaches in diseases with increased Ras signaling.
    findings: []
  - id: PMID:20936779
    title: A human MAP kinase interactome.
    findings: []
  - id: PMID:21081150
    title: Pore-forming activity of BAD is regulated by specific phosphorylation
      and structural transitions of the C-terminal part.
    findings: []
  - id: PMID:21182262
    title: 'Structural characterization of partially disordered human Chibby: insights
      into its function in the Wnt-signaling pathway.'
    findings: []
  - id: PMID:21282530
    title: Interaction proteomics analysis of polycomb proteins defines distinct
      PRC1 complexes in mammalian cells.
    findings: []
  - id: PMID:21423176
    title: Analysis of the myosin-II-responsive focal adhesion proteome reveals 
      a role for β-Pix in negative regulation of focal adhesion maturation.
    findings: []
  - id: PMID:21554249
    title: 'NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation
      of the chaperone and phosphoserine-binding activities of 14-3-3ζ.'
    findings: []
  - id: PMID:21621563
    title: Bimodal regulation of FoxO3 by AKT and 14-3-3.
    findings: []
  - id: PMID:21630459
    title: Proteomic characterization of the human sperm nucleus.
    findings: []
  - id: PMID:21988832
    title: Toward an understanding of the protein interaction network of the 
      human liver.
    findings: []
  - id: PMID:22516433
    title: Proteomic analysis of microvesicles from plasma of healthy donors 
      reveals high individual variability.
    findings: []
  - id: PMID:22575644
    title: 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 
      336 residue and suppresses LKB1 kinase function.
    findings: []
  - id: PMID:22580824
    title: ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated 
      disintegration.
    findings: []
  - id: PMID:22653443
    title: Mutant p53 interactome identifies nardilysin as a p53R273H-specific 
      binding partner that promotes invasion.
    findings: []
  - id: PMID:22658674
    title: Insights into RNA biology from an atlas of mammalian mRNA-binding 
      proteins.
    findings: []
  - id: PMID:23075850
    title: Progressive degeneration of human neural stem cells caused by 
      pathogenic LRRK2.
    findings: []
  - id: PMID:23397142
    title: Analysis of protein-protein interactions in cross-talk pathways 
      reveals CRKL protein as a novel prognostic marker in hepatocellular 
      carcinoma.
    findings: []
  - id: PMID:23414517
    title: 'A human skeletal muscle interactome centered on proteins involved in muscular
      dystrophies: LGMD interactome.'
    findings: []
  - id: PMID:23455924
    title: A Y2H-seq approach defines the human protein methyltransferase 
      interactome.
    findings: []
  - id: PMID:23533145
    title: In-depth proteomic analyses of exosomes isolated from expressed 
      prostatic secretions in urine.
    findings: []
  - id: PMID:23572552
    title: ACBD3 interaction with TBC1 domain 22 protein is differentially 
      affected by enteroviral and kobuviral 3A protein binding.
    findings: []
  - id: PMID:23580065
    title: Shotgun proteomics reveals specific modulated protein patterns in 
      tears of patients with primary open angle glaucoma naïve to therapy.
    findings: []
  - id: PMID:23622247
    title: 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif 
      to inhibit G proteins.
    findings: []
  - id: PMID:23752268
    title: The functional interactome landscape of the human histone deacetylase
      family.
    findings: []
  - id: PMID:24255178
    title: Protein interaction network of the mammalian Hippo pathway reveals 
      mechanisms of kinase-phosphatase interactions.
    findings: []
  - id: PMID:24351927
    title: Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA 
      phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
    findings: []
  - id: PMID:24510904
    title: Unbiased screen for interactors of leucine-rich repeat kinase 2 
      supports a common pathway for sporadic and familial Parkinson disease.
    findings: []
  - id: PMID:24658140
    title: The mammalian-membrane two-hybrid assay (MaMTH) for probing 
      membrane-protein interactions in human cells.
    findings: []
  - id: PMID:24947832
    title: Differential protein-protein interactions of LRRK1 and LRRK2 indicate
      roles in distinct cellular signaling pathways.
    findings: []
  - id: PMID:25189701
    title: A quantitative 14-3-3 interaction screen connects the nuclear exosome
      targeting complex to the DNA damage response.
    findings: []
  - id: PMID:25277244
    title: The functional landscape of Hsp27 reveals new cellular processes such
      as DNA repair and alternative splicing and proposes novel anticancer 
      targets.
    findings: []
  - id: PMID:25468996
    title: E-cadherin interactome complexity and robustness resolved by 
      quantitative proteomics.
    findings: []
  - id: PMID:25670079
    title: 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis 
      promoter in breast cancer by contextual changes of Smad partners from p53 
      to Gli2.
    findings: []
  - id: PMID:25852190
    title: Integrative analysis of kinase networks in TRAIL-induced apoptosis 
      provides a source of potential targets for combination therapy.
    findings: []
  - id: PMID:25959826
    title: Quantitative interaction proteomics of neurodegenerative disease 
      proteins.
    findings: []
  - id: PMID:26496610
    title: A human interactome in three quantitative dimensions organized by 
      stoichiometries and abundances.
    findings: []
  - id: PMID:27030597
    title: Familial autoinflammation with neutrophilic dermatosis reveals a 
      regulatory mechanism of pyrin activation.
    findings: []
  - id: PMID:27291054
    title: Isolation of Functional Tubulin Dimers and of Tubulin-Associated 
      Proteins from Mammalian Cells.
    findings: []
  - id: PMID:27880917
    title: Phenotypic and Interaction Profiling of the Human Phosphatases 
      Identifies Diverse Mitotic Regulators.
    findings: []
  - id: PMID:28330616
    title: Systematic Analysis of Human Protein Phosphatase Interactions and 
      Dynamics.
    findings: []
  - id: PMID:28514442
    title: Architecture of the human interactome defines protein communities and
      disease networks.
    findings: []
  - id: PMID:28575131
    title: Bacterial co-expression of human Tau protein with protein kinase A 
      and 14-3-3 for studies of 14-3-3/phospho-Tau interaction.
    findings: []
  - id: PMID:29100370
    title: Identification of the PAK4 interactome reveals PAK4 phosphorylation 
      of N-WASP and promotion of Arp2/3-dependent actin polymerization.
    findings: []
  - id: PMID:29408703
    title: Structural characterization of 14-3-3ζ in complex with the human Son 
      of sevenless homolog 1 (SOS1).
    findings: []
  - id: PMID:31024343
    title: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome 
      Activates the RAF-ERK Pathway.
    findings: []
  - id: PMID:31046837
    title: Parkinson's disease-associated LRRK2-G2019S mutant acts through 
      regulation of SERCA activity to control ER stress in astrocytes.
    findings: []
  - id: PMID:31413325
    title: HENA, heterogeneous network-based data set for Alzheimer's disease.
    findings: []
  - id: PMID:31906564
    title: Differential Subcellular Distribution and Translocation of Seven 
      14-3-3 Isoforms in Response to EGF and During the Cell Cycle.
    findings: []
  - id: PMID:31980649
    title: Extensive rewiring of the EGFR network in colorectal cancer cells 
      expressing transforming levels of KRAS(G13D).
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:32707033
    title: Kinase Interaction Network Expands Functional and Disease Roles of 
      Human Kinases.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: PMID:33961781
    title: Dual proteome-scale networks reveal cell-specific remodeling of the 
      human interactome.
    findings: []
  - id: PMID:34927784
    title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is
      downregulated in breast cancer.
    findings: []
  - id: PMID:35271311
    title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
    findings: []
  - id: PMID:35512704
    title: Systematic discovery of mutation-directed neo-protein-protein 
      interactions in cancer.
    findings: []
  - id: PMID:35662396
    title: Itaconate is a lysosomal inducer that promotes antibacterial innate 
      immunity.
    findings: []
  - id: PMID:36096339
    title: Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 
      proteins.
    findings: []
  - id: PMID:36931259
    title: A central chaperone-like role for 14-3-3 proteins in human cells.
    findings: []
  - id: PMID:37045861
    title: Interactome dynamics of RAF1-BRAF kinase monomers and dimers.
    findings: []
  - id: PMID:37776851
    title: Analysis of proteome-wide degradation dynamics in ALS SOD1 
      iPSC-derived patient neurons reveals disrupted VCP homeostasis.
    findings: []
  - id: PMID:39251607
    title: Systematic identification of post-transcriptional regulatory modules.
    findings: []
  - id: PMID:40205054
    title: Multimodal cell maps as a foundation for structural and functional 
      genomics.
    findings: []
  - id: PMID:7935795
    title: Activation of Raf-1 by 14-3-3 proteins.
    findings: []
  - id: PMID:7939632
    title: Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
    findings: []
  - id: PMID:8085158
    title: Binding of 14-3-3 proteins to the protein kinase Raf and effects on 
      its activation.
    findings: []
  - id: PMID:8601312
    title: Interaction of 14-3-3 with signaling proteins is mediated by the 
      recognition of phosphoserine.
    findings: []
  - id: PMID:9153224
    title: Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a 
      common site involving lysine 49.
    findings: []
  - id: PMID:9543386
    title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and 
      promotes 14-3-3 protein binding.
    findings: []
  - id: Reactome:R-HSA-139899
    title: Sequestration of BAD protein by 14-3-3
    findings: []
  - id: Reactome:R-HSA-139906
    title: Activation of BAD by calcineurin
    findings: []
  - id: Reactome:R-HSA-3769391
    title: XPO1 binds the beta-catenin:CBY complex
    findings: []
  - id: Reactome:R-HSA-3769392
    title: YWHAZ and XPO1 mediate the nuclear export of beta-catenin
    findings: []
  - id: Reactome:R-HSA-3769393
    title: YWHAZ binds p-CBY:CTNNB1
    findings: []
  - id: Reactome:R-HSA-430073
    title: GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
    findings: []
  - id: Reactome:R-HSA-430076
    title: GP1b-IX-V binds 14-3-3-zeta
    findings: []
  - id: Reactome:R-HSA-443402
    title: GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
    findings: []
  - id: Reactome:R-HSA-443831
    title: 14-3-3-zeta binds Raf1
    findings: []
  - id: Reactome:R-HSA-450620
    title: p-S193-KSRP binds 14-3-3zeta in the nucleus
    findings: []
  - id: Reactome:R-HSA-5632732
    title: p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by 
      DDIT4
    findings: []
  - id: Reactome:R-HSA-5632738
    title: DDIT4 binds 14-3-3 dimer
    findings: []
  - id: Reactome:R-HSA-75016
    title: Association of p-S216-CDC25C with 14-3-3 proteins
    findings: []
  - id: Reactome:R-HSA-912757
    title: p-S585-IL3RB binds 14-3-3 proteins
    findings: []
  - id: Reactome:R-HSA-913993
    title: 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
    findings: []
  - id: Reactome:R-HSA-914182
    title: 14-3-3 zeta binding allows recruitment of PI3K
    findings: []
  - id: Reactome:R-HSA-9614423
    title: 14-3-3 proteins bind AKT-phosphorylated FOXO1
    findings: []
  - id: Reactome:R-HSA-9614562
    title: 14-3-3 proteins bind AKT-phosphorylated FOXO3
    findings: []
  - id: Reactome:R-HSA-9614564
    title: 14-3-3 proteins bind AKT-phosphorylated FOXO4
    findings: []
  - id: Reactome:R-HSA-9727919
    title: SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins
    findings: []
  - id: Reactome:R-HSA-9729500
    title: SARS-CoV-2 N binds to 14-3-3 proteins
    findings: []