YWHAZ

id: P63104
gene_symbol: YWHAZ
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: >-
  14-3-3 protein zeta/delta (YWHAZ) is an adapter protein that functions as a dimeric
  scaffold recognizing phosphoserine/phosphothreonine motifs in client proteins. The
  core molecular function is phosphoserine/phosphothreonine-dependent protein binding
  within a conserved amphipathic groove formed by helices C/E/G/I. YWHAZ forms homodimers
  and heterodimers (notably with YWHAE) and primarily localizes to the cytosol, though
  it can shuttle to the nucleus with certain clients. Key functional roles include:
  (1) cytoplasmic sequestration of transcription factors (FOXO family, YAP/TAZ, TFEB);
  (2) regulation of RAF/MEK/ERK MAPK signaling by scaffolding RAF kinases; (3) modulation
  of PI3K-AKT pathway through BAD sequestration and regulation of mTORC1 via raptor binding;
  (4) regulation of cell cycle checkpoints via CDC25 phosphatase binding; (5) protein
  stabilization through chaperone-like activity. The protein binds hundreds of client
  proteins in a phosphorylation-dependent manner via canonical Mode I (RSXpSXP), Mode II
  (RXY/FXpSXP), and Mode III (C-terminal pS/pT) motifs.
existing_annotations:
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS).
    action: ACCEPT
    reason: Core cytoplasmic localization of the adapter.
- term:
    id: GO:0008104
    label: intracellular protein localization
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: IBA-inferred role in positioning client proteins; a generic restatement of the localization control achieved through phospho-client binding.
    action: KEEP_AS_NON_CORE
    reason: Generic IBA localization-control process; subsumed by sequestration.
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS).
    action: ACCEPT
    reason: Adapter coupling of phospho-clients is the core signaling role.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS).
    action: ACCEPT
    reason: Core cytoplasmic localization of the adapter.
- term:
    id: GO:0042470
    label: melanosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: Detected in melanosome proteomes (PMID:17081065); an organelle-association from large-scale profiling rather than a defining site of function.
    action: KEEP_AS_NON_CORE
    reason: Proteomic organelle association; non-core localization.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338).
    action: ACCEPT
    reason: Homodimerization is structurally core, not generic protein binding.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10102273
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:10102273
      supporting_text: >-
        Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3
        proteins and FKHRL1's retention in the cytoplasm.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10642536
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:10642536
      supporting_text: >-
        We have identified 14-3-3zeta as an hIL-9Ralpha-interacting protein. We
        also mapped residues 518-522 (Arg-Ser(519)-Trp-Thr(521)-Phe) in hIL-9Ralpha
        and helix I of 14-3-3zeta as being important for interaction.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10713667
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10840038
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10887173
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11237865
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11336675
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:11336675
      supporting_text: >-
        AANAT is bound in the central channel of the 14-3-3zeta dimer, and is
        held in place by extensive interactions both with the amphipathic
        phosphopeptide binding groove of 14-3-3zeta and with other parts of
        the central channel.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11504882
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11526496
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11697890
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:11697890
      supporting_text: Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11723239
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:11723239
      supporting_text: 14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11864996
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:11864996
      supporting_text: Feb 25. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12154078
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12154078
      supporting_text: Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12176984
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12176984
      supporting_text: 2002 Aug 9. Identification and characterization of the interaction between tuberin and 14-3-3zeta.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12361576
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12361576
      supporting_text: 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12383250
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12383250
      supporting_text: A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12438239
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12438239
      supporting_text: 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12468542
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12468542
      supporting_text: 2002 Dec 4. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12589811
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12589811
      supporting_text: 'The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12615066
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12615066
      supporting_text: Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12757707
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12757707
      supporting_text: Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12764136
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12764136
      supporting_text: 2003 May 22. 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12766774
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12766774
      supporting_text: Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12819209
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12819209
      supporting_text: 2003 Jun 20. Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12941695
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12941695
      supporting_text: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12944463
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12944463
      supporting_text: Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12963375
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12963375
      supporting_text: 'Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14676191
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:14676191
      supporting_text: 2003 Dec 15. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14688280
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:14688280
      supporting_text: '2003 Dec 19. Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14743216
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:14743216
      supporting_text: A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14970201
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:14970201
      supporting_text: 2004 Feb 17. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15023544
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15023544
      supporting_text: Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15037601
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15037601
      supporting_text: Mar 22. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15161933
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15161933
      supporting_text: 2004 May 25. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15225635
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15225635
      supporting_text: Identification of 14-3-3zeta as an EGF receptor interacting protein.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15314064
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15314064
      supporting_text: Raf-1 activation disrupts its binding to keratins during cell stress.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15324659
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15324659
      supporting_text: aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15324660
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15324660
      supporting_text: Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15629715
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15629715
      supporting_text: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15657067
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15657067
      supporting_text: Epub 2005 Jan 17. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15696159
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15696159
      supporting_text: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15964851
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:15964851
      supporting_text: 2005 Jun 17. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16246723
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16246723
      supporting_text: Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16306228
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16306228
      supporting_text: 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16376338
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16376338
      supporting_text: 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16449798
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16449798
      supporting_text: Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16511560
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16511560
      supporting_text: Mar 2. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16636147
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16636147
      supporting_text: Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16672277
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16672277
      supporting_text: Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16868027
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16868027
      supporting_text: Jul 25. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16959763
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:16959763
      supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17043677
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:17043677
      supporting_text: 'Oct 17. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17166838
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:17166838
      supporting_text: 2006 Dec 13. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17317006
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:17317006
      supporting_text: Epub 2007 Feb 3. 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17353931
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:17353931
      supporting_text: Large-scale mapping of human protein-protein interactions by mass spectrometry.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17979178
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:17979178
      supporting_text: A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18418070
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:18418070
      supporting_text: Mar 11. Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18573912
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:18573912
      supporting_text: Jun 23. Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18647389
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:18647389
      supporting_text: The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19049963
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19049963
      supporting_text: '2008 Dec 2. Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19138662
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19138662
      supporting_text: Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19357195
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19357195
      supporting_text: 2009 Apr 8. Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19481529
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19481529
      supporting_text: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19647741
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19647741
      supporting_text: Epub 2009 Aug 3. Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19662078
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19662078
      supporting_text: Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19667065
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19667065
      supporting_text: 'Epub 2009 Aug 10. Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19720745
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19720745
      supporting_text: Aug 31. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19732720
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19732720
      supporting_text: 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19766566
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19766566
      supporting_text: Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19860830
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19860830
      supporting_text: 2009 Oct 27. The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19933840
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19933840
      supporting_text: Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19940019
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19940019
      supporting_text: 2009 Nov 25. Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20037628
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20037628
      supporting_text: Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20052757
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20052757
      supporting_text: 'Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20224040
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20224040
      supporting_text: 2010 Mar 11. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20451386
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20451386
      supporting_text: 2010 May 6. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20603015
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20603015
      supporting_text: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20618440
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20618440
      supporting_text: 2010 Jul 8. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20642453
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20642453
      supporting_text: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20679480
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20679480
      supporting_text: Aug 2. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20936779
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:20936779
      supporting_text: A human MAP kinase interactome.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21282530
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:21282530
      supporting_text: Epub 2011 Jan 31. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21988832
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:21988832
      supporting_text: Toward an understanding of the protein interaction network of the human liver.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22575644
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:22575644
      supporting_text: 2012 Mar 23. 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22580824
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:22580824
      supporting_text: ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22653443
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:22653443
      supporting_text: Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23075850
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23075850
      supporting_text: Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23397142
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23397142
      supporting_text: Epub 2013 Feb 8. Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23414517
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23414517
      supporting_text: 'A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23455924
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23455924
      supporting_text: A Y2H-seq approach defines the human protein methyltransferase interactome.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23622247
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23622247
      supporting_text: 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23752268
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23752268
      supporting_text: The functional interactome landscape of the human histone deacetylase family.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24255178
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:24255178
      supporting_text: Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24351927
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:24351927
      supporting_text: Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24510904
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:24510904
      supporting_text: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24658140
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:24658140
      supporting_text: The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24947832
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:24947832
      supporting_text: Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25277244
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:25277244
      supporting_text: Epub 2014 Oct 2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25670079
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:25670079
      supporting_text: 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25852190
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:25852190
      supporting_text: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25959826
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:25959826
      supporting_text: 2015 May 7. Quantitative interaction proteomics of neurodegenerative disease proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26496610
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:26496610
      supporting_text: Oct 22. A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27291054
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:27291054
      supporting_text: 2016 Jun 9. Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27880917
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:27880917
      supporting_text: Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28330616
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:28330616
      supporting_text: 2017 Mar 18. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:28514442
      supporting_text: Architecture of the human interactome defines protein communities and disease networks.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28575131
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:28575131
      supporting_text: eCollection 2017. Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29100370
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:29100370
      supporting_text: eCollection 2017 Sep 29.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29408703
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:29408703
      supporting_text: 2018 Feb 1. Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31046837
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:31046837
      supporting_text: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31413325
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:31413325
      supporting_text: HENA, heterogeneous network-based data set for Alzheimer's disease.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31980649
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:31980649
      supporting_text: Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:32296183
      supporting_text: Apr 8. A reference map of the human binary protein interactome.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32707033
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:32707033
      supporting_text: 2020 Jul 23. Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32814053
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:32814053
      supporting_text: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:33961781
      supporting_text: 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:34927784
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:34927784
      supporting_text: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:35271311
      supporting_text: '2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35512704
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:35512704
      supporting_text: 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:36096339
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:36096339
      supporting_text: Sep 9. Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:36931259
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:36931259
      supporting_text: A central chaperone-like role for 14-3-3 proteins in human cells.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37045861
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:37045861
      supporting_text: Interactome dynamics of RAF1-BRAF kinase monomers and dimers.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37776851
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:37776851
      supporting_text: 2023 Sep 29. Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:39251607
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:39251607
      supporting_text: Systematic identification of post-transcriptional regulatory modules.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:40205054
      supporting_text: Apr 9. Multimodal cell maps as a foundation for structural and functional genomics.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7935795
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:7935795
      supporting_text: Activation of Raf-1 by 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7939632
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:7939632
      supporting_text: Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8085158
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:8085158
      supporting_text: Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8601312
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:8601312
      supporting_text: Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9153224
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:9153224
      supporting_text: Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:16376338
  review:
    summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338).
    action: ACCEPT
    reason: Homodimerization is structurally core, not generic protein binding.
    supported_by: &id001
    - reference_id: PMID:16376338
      supporting_text: 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:20618440
  review:
    summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338).
    action: ACCEPT
    reason: Homodimerization is structurally core, not generic protein binding.
    supported_by:
    - reference_id: PMID:20618440
      supporting_text: 2010 Jul 8. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: Indirect transcriptional repression via cytoplasmic retention of TFs and binding of class-IIa HDACs; a downstream consequence rather than a direct DNA/chromatin function (IDA/IEA).
    action: KEEP_AS_NON_CORE
    reason: Indirect transcriptional effect of TF sequestration; non-core.
- term:
    id: GO:0001525
    label: angiogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA-projected role in angiogenesis reflecting 14-3-3 zeta's involvement in growth/survival signaling; a broad pleiotropic physiological output.
    action: KEEP_AS_NON_CORE
    reason: Broad IEA physiological process; non-core.
- term:
    id: GO:0003016
    label: respiratory system process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA-projected physiological process; a pleiotropic organ-system annotation far removed from the molecular adapter function.
    action: KEEP_AS_NON_CORE
    reason: Pleiotropic IEA physiological process; non-core.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear pool; non-core localization.
- term:
    id: GO:0008039
    label: synaptic target recognition
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA-inferred role in synaptic target recognition; a specialized neuronal process attributable to 14-3-3 client regulation rather than its core MF.
    action: KEEP_AS_NON_CORE
    reason: Specialized IEA neuronal process; non-core.
- term:
    id: GO:0019904
    label: protein domain specific binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 14-3-3 zeta engages defined phospho-motif segments (Mode I/II/III linear motifs) of partner domains rather than binding indiscriminately, the basis of its scaffold function.
    action: ACCEPT
    reason: Reflects specific motif/domain recognition central to 14-3-3 function.
- term:
    id: GO:0030324
    label: lung development
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA-projected developmental role; a pleiotropic organ-development annotation downstream of ubiquitous signaling functions, not a defining role.
    action: KEEP_AS_NON_CORE
    reason: Pleiotropic IEA developmental process; non-core.
- term:
    id: GO:0035148
    label: tube formation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA-projected morphogenetic process (e.g. vascular/epithelial tube formation); a broad developmental output of signaling roles, not core.
    action: KEEP_AS_NON_CORE
    reason: Broad IEA morphogenetic process; non-core.
- term:
    id: GO:0098686
    label: hippocampal mossy fiber to CA3 synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: IEA electronic localization to a specific hippocampal synapse type; reflects neuronal synaptic roles but is highly specialized and non-core.
    action: KEEP_AS_NON_CORE
    reason: Highly specialized IEA synaptic localization; non-core.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:21621563
  review:
    summary: Indirect transcriptional repression via cytoplasmic retention of TFs and binding of class-IIa HDACs; a downstream consequence rather than a direct DNA/chromatin function (IDA/IEA).
    action: KEEP_AS_NON_CORE
    reason: Indirect transcriptional effect of TF sequestration; non-core.
    supported_by:
    - reference_id: PMID:21621563
      supporting_text: Bimodal regulation of FoxO3 by AKT and 14-3-3.
- term:
    id: GO:0019903
    label: protein phosphatase binding
  evidence_type: IPI
  original_reference_id: PMID:9543386
  review:
    summary: Reflects binding to phosphatase clients such as the cofilin phosphatase Slingshot (SSH1); a partner-class binding, not the defining MF (PMID:15159416, PMID:15660133).
    action: KEEP_AS_NON_CORE
    reason: Partner-class binding; corroborating but non-core.
    supported_by:
    - reference_id: PMID:9543386
      supporting_text: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:31906564
  review:
    summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear pool; non-core localization.
    supported_by:
    - reference_id: PMID:31906564
      supporting_text: Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:31906564
  review:
    summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS).
    action: ACCEPT
    reason: Core cytoplasmic localization of the adapter.
    supported_by:
    - reference_id: PMID:31906564
      supporting_text: Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle.
- term:
    id: GO:0090128
    label: regulation of synapse maturation
  evidence_type: IDA
  original_reference_id: PMID:16959763
  review:
    summary: 14-3-3 zeta regulates spine/synapse maturation by modulating ARHGEF7 activity on RAC1; a neuron-specific developmental role downstream of adapter binding (IDA/IMP).
    action: KEEP_AS_NON_CORE
    reason: Neuron-specific developmental output; non-core.
    supported_by:
    - reference_id: PMID:16959763
      supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
- term:
    id: GO:0090128
    label: regulation of synapse maturation
  evidence_type: IMP
  original_reference_id: PMID:16959763
  review:
    summary: 14-3-3 zeta regulates spine/synapse maturation by modulating ARHGEF7 activity on RAC1; a neuron-specific developmental role downstream of adapter binding (IDA/IMP).
    action: KEEP_AS_NON_CORE
    reason: Neuron-specific developmental output; non-core.
    supported_by:
    - reference_id: PMID:16959763
      supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:16959763
  review:
    summary: Synaptic localization tied to 14-3-3 zeta roles in spine/synapse maturation via ARHGEF7; a tissue-specific site rather than its general adapter compartment.
    action: KEEP_AS_NON_CORE
    reason: Neuron-specific localization; non-core.
    supported_by:
    - reference_id: PMID:16959763
      supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IMP
  original_reference_id: PMID:16959763
  review:
    summary: Synaptic localization tied to 14-3-3 zeta roles in spine/synapse maturation via ARHGEF7; a tissue-specific site rather than its general adapter compartment.
    action: KEEP_AS_NON_CORE
    reason: Neuron-specific localization; non-core.
    supported_by:
    - reference_id: PMID:16959763
      supporting_text: Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: IPI
  original_reference_id: PMID:18029012
  review:
    summary: Reflects binding to membrane transporter/channel clients (e.g. ITGB2, ADAM22); a specific partner interaction, not the defining phospho-adapter MF.
    action: KEEP_AS_NON_CORE
    reason: Specific partner-class binding; peripheral to core function.
    supported_by:
    - reference_id: PMID:18029012
      supporting_text: 2007 Oct 29. Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.
- term:
    id: GO:1900181
    label: negative regulation of protein localization to nucleus
  evidence_type: IDA
  original_reference_id: PMID:35662396
  review:
    summary: 14-3-3 zeta retains phospho-clients (FOXO, TFEB, ABL1) in the cytoplasm, blocking their nuclear entry; a direct but downstream consequence of sequestration (IDA).
    action: KEEP_AS_NON_CORE
    reason: Downstream localization-control output of adapter binding; non-core.
    supported_by:
    - reference_id: PMID:35662396
      supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
- term:
    id: GO:0042149
    label: cellular response to glucose starvation
  evidence_type: IDA
  original_reference_id: PMID:18439900
  review:
    summary: IDA-supported response to glucose starvation, consistent with 14-3-3 zeta integrating metabolic/AMPK-AKT signaling (e.g. TFEB control); a specific stress response, not core MF.
    action: KEEP_AS_NON_CORE
    reason: Specific stress-response process; downstream of adapter activity.
    supported_by:
    - reference_id: PMID:18439900
      supporting_text: AMPK phosphorylation of raptor mediates a metabolic checkpoint.
- term:
    id: GO:0140311
    label: protein sequestering activity
  evidence_type: IDA
  original_reference_id: PMID:18439900
  review:
    summary: 'Core mechanistic output: by binding phospho-clients (TFEB, BAX, ABL1, FOXO, MLF1) 14-3-3 zeta sequesters them, controlling localization/activation (PMID:35662396, PMID:15071501).'
    action: ACCEPT
    reason: Sequestration is the direct functional consequence of adapter binding; IDA core.
    supported_by:
    - reference_id: PMID:18439900
      supporting_text: AMPK phosphorylation of raptor mediates a metabolic checkpoint.
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: IDA
  original_reference_id: PMID:18439900
  review:
    summary: 14-3-3 zeta binds TSC2/PRAS40-type clients to modulate mTORC1; a specific pathway-level effect downstream of its adapter activity (IDA).
    action: KEEP_AS_NON_CORE
    reason: Specific pathway regulation; downstream of core MF.
    supported_by:
    - reference_id: PMID:18439900
      supporting_text: AMPK phosphorylation of raptor mediates a metabolic checkpoint.
- term:
    id: GO:0045824
    label: negative regulation of innate immune response
  evidence_type: IDA
  original_reference_id: PMID:35662396
  review:
    summary: 14-3-3 zeta binds TRIM25 to dampen RIG-I-dependent type-I IFN signaling (exploited by EBV BPLF1); a specific immunoregulatory output (PMID:29357390, PMID:31710640).
    action: KEEP_AS_NON_CORE
    reason: Specific immune-pathway regulation; downstream effect.
    supported_by:
    - reference_id: PMID:35662396
      supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:35662396
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
    supported_by:
    - reference_id: PMID:35662396
      supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
- term:
    id: GO:0050815
    label: phosphoserine residue binding
  evidence_type: IDA
  original_reference_id: PMID:35662396
  review:
    summary: 'Directly captures the defining 14-3-3 zeta MF: binding phosphoserine motifs in client proteins. Crystal structures show pSer/pThr coordination in the amphipathic groove (PMID:10488331, PMID:16246723).'
    action: ACCEPT
    reason: Defining phospho-Ser-binding adapter activity; IDA-supported core MF.
    supported_by:
    - reference_id: PMID:35662396
      supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
- term:
    id: GO:0140311
    label: protein sequestering activity
  evidence_type: IDA
  original_reference_id: PMID:35662396
  review:
    summary: 'Core mechanistic output: by binding phospho-clients (TFEB, BAX, ABL1, FOXO, MLF1) 14-3-3 zeta sequesters them, controlling localization/activation (PMID:35662396, PMID:15071501).'
    action: ACCEPT
    reason: Sequestration is the direct functional consequence of adapter binding; IDA core.
    supported_by:
    - reference_id: PMID:35662396
      supporting_text: Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
- term:
    id: GO:0031647
    label: regulation of protein stability
  evidence_type: EXP
  original_reference_id: PMID:21554249
  review:
    summary: 14-3-3 zeta binding protects clients such as AANAT from dephosphorylation and proteasomal degradation; a downstream stabilizing effect of adapter binding (EXP, PMID:15644438).
    action: KEEP_AS_NON_CORE
    reason: Downstream client-stability effect; non-core.
    supported_by:
    - reference_id: PMID:21554249
      supporting_text: 'NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.'
- term:
    id: GO:0140297
    label: DNA-binding transcription factor binding
  evidence_type: IPI
  original_reference_id: PMID:16114898
  review:
    summary: 14-3-3 zeta binds phosphorylated transcription factors (TP53, FOXO1/3/4, TFEB) to control their nuclear access; a specific client-class interaction underlying transcriptional regulation (PMID:16114898).
    action: KEEP_AS_NON_CORE
    reason: Specific TF-client binding; mechanistic context, not core MF.
    supported_by:
    - reference_id: PMID:16114898
      supporting_text: 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27030597
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:27030597
      supporting_text: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:31024343
  review:
    summary: 14-3-3 zeta has no kinase activity; it is phosphorylated by clients (AKT1, CK1, PKA) and regulates kinases. The IMP-supported observation is best recast as regulation of phosphorylation, not catalysis.
    action: MODIFY
    reason: 14-3-3 is not a kinase; reframe to regulation of phosphorylation.
    proposed_replacement_terms:
    - id: GO:0042325
      label: regulation of phosphorylation
    supported_by:
    - reference_id: PMID:31024343
      supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: IMP
  original_reference_id: PMID:31024343
  review:
    summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS).
    action: ACCEPT
    reason: Adapter coupling of phospho-clients is the core signaling role.
    supported_by:
    - reference_id: PMID:31024343
      supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31024343
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:31024343
      supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
- term:
    id: GO:0070372
    label: regulation of ERK1 and ERK2 cascade
  evidence_type: IDA
  original_reference_id: PMID:31024343
  review:
    summary: By scaffolding phospho-RAF1/BRAF, 14-3-3 zeta tunes RAF-ERK signaling (a YWHAZ CFC-syndrome variant hyperactivates it); a pathway-specific downstream role (PMID:31024343).
    action: KEEP_AS_NON_CORE
    reason: Specific MAPK-pathway regulation; downstream consequence.
    supported_by:
    - reference_id: PMID:31024343
      supporting_text: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25189701
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:25189701
      supporting_text: Sep 4. A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.
- term:
    id: GO:0045296
    label: cadherin binding
  evidence_type: HDA
  original_reference_id: PMID:25468996
  review:
    summary: High-throughput (HDA) capture of 14-3-3 zeta at cadherin/junctional complexes; a specific partner association rather than its core adapter activity.
    action: KEEP_AS_NON_CORE
    reason: Specific HDA partner association; non-core.
    supported_by:
    - reference_id: PMID:25468996
      supporting_text: E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
- term:
    id: GO:0031982
    label: vesicle
  evidence_type: HDA
  original_reference_id: PMID:19190083
  review:
    summary: HDA vesicle-associated detection, in line with exosome/microparticle capture of abundant cytosolic 14-3-3 zeta; not a defining functional site.
    action: KEEP_AS_NON_CORE
    reason: HDA vesicle-fraction capture; non-core localization.
    supported_by:
    - reference_id: PMID:19190083
      supporting_text: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21182262
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:21182262
      supporting_text: 'Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.'
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23572552
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:23572552
      supporting_text: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:19725078
  review:
    summary: Captures binding to E3-ligase clients (e.g. TRIM25, NEDD4-2) where 14-3-3 modulates ligase activity; specific partner-class interaction rather than core MF (PMID:31710640).
    action: KEEP_AS_NON_CORE
    reason: Specific partner-class binding; downstream regulatory context.
    supported_by:
    - reference_id: PMID:19725078
      supporting_text: Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
- term:
    id: GO:0090168
    label: Golgi reassembly
  evidence_type: IMP
  original_reference_id: PMID:20332113
  review:
    summary: IMP-supported role in post-mitotic Golgi reassembly, consistent with 14-3-3 binding trafficking regulators; a specialized trafficking process downstream of adapter activity.
    action: KEEP_AS_NON_CORE
    reason: Specialized trafficking process; non-core.
    supported_by:
    - reference_id: PMID:20332113
      supporting_text: Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
- term:
    id: GO:0051683
    label: establishment of Golgi localization
  evidence_type: IMP
  original_reference_id: PMID:20332113
  review:
    summary: IMP-supported contribution to positioning the Golgi, in line with 14-3-3 zeta binding trafficking/cytoskeletal regulators; a specialized downstream process.
    action: KEEP_AS_NON_CORE
    reason: Specialized trafficking-positioning process; non-core.
    supported_by:
    - reference_id: PMID:20332113
      supporting_text: Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: HDA
  original_reference_id: PMID:21423176
  review:
    summary: HDA detection at focal adhesions, consistent with 14-3-3 zeta acting on adhesion/cytoskeletal regulators (ARHGEF2, SSH1); a specific subcellular association, not core.
    action: KEEP_AS_NON_CORE
    reason: HDA adhesion-site association; non-core localization.
    supported_by:
    - reference_id: PMID:21423176
      supporting_text: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:23533145
  review:
    summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment.
    action: KEEP_AS_NON_CORE
    reason: Abundant-protein exosome capture; non-core localization.
    supported_by:
    - reference_id: PMID:23533145
      supporting_text: 2013 Apr 23. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
- term:
    id: GO:0005615
    label: extracellular space
  evidence_type: HDA
  original_reference_id: PMID:16502470
  review:
    summary: HDA extracellular detection, consistent with vesicle-mediated release of this cytosolic adapter rather than a secreted function.
    action: KEEP_AS_NON_CORE
    reason: HDA extracellular capture; non-core localization.
    supported_by:
    - reference_id: PMID:16502470
      supporting_text: 'Human colostrum: identification of minor proteins in the aqueous phase by proteomics.'
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: HDA
  original_reference_id: PMID:21630459
  review:
    summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear pool; non-core localization.
    supported_by:
    - reference_id: PMID:21630459
      supporting_text: Jun 1. Proteomic characterization of the human sperm nucleus.
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22658674
  review:
    summary: HDA RNA-interactome capture lists 14-3-3 zeta, but it is a phosphopeptide adapter with no recognized sequence-specific RNA-binding role; likely an indirect/RNP co-capture artifact.
    action: MARK_AS_OVER_ANNOTATED
    reason: HDA interactome capture; no established direct RNA-binding function.
    supported_by:
    - reference_id: PMID:22658674
      supporting_text: May 31. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
- term:
    id: GO:0072562
    label: blood microparticle
  evidence_type: HDA
  original_reference_id: PMID:22516433
  review:
    summary: HDA detection in blood microparticles reflects abundance/release of this cytosolic protein into extracellular vesicles, not an intrinsic functional site.
    action: KEEP_AS_NON_CORE
    reason: Extracellular-vesicle proteomic capture; non-core.
    supported_by:
    - reference_id: PMID:22516433
      supporting_text: Epub 2012 Apr 10. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
- term:
    id: GO:0005615
    label: extracellular space
  evidence_type: HDA
  original_reference_id: PMID:23580065
  review:
    summary: HDA extracellular detection, consistent with vesicle-mediated release of this cytosolic adapter rather than a secreted function.
    action: KEEP_AS_NON_CORE
    reason: HDA extracellular capture; non-core localization.
    supported_by:
    - reference_id: PMID:23580065
      supporting_text: Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:19199708
  review:
    summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment.
    action: KEEP_AS_NON_CORE
    reason: Abundant-protein exosome capture; non-core localization.
    supported_by:
    - reference_id: PMID:19199708
      supporting_text: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:19056867
  review:
    summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment.
    action: KEEP_AS_NON_CORE
    reason: Abundant-protein exosome capture; non-core localization.
    supported_by:
    - reference_id: PMID:19056867
      supporting_text: 2008 Dec 3. Large-scale proteomics and phosphoproteomics of urinary exosomes.
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:20458337
  review:
    summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment.
    action: KEEP_AS_NON_CORE
    reason: Abundant-protein exosome capture; non-core localization.
    supported_by:
    - reference_id: PMID:20458337
      supporting_text: 2010 May 11. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3769391
  review:
    summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear-compartment localization; non-core.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3769392
  review:
    summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear-compartment localization; non-core.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3769393
  review:
    summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear-compartment localization; non-core.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-450620
  review:
    summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
    action: KEEP_AS_NON_CORE
    reason: Secondary nuclear-compartment localization; non-core.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-139899
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-139906
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3769392
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-430073
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-430076
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-443402
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-443831
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5632732
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5632738
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-75016
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-912757
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-913993
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-914182
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9614423
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9614562
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9614564
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9727919
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9729500
  review:
    summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
    action: ACCEPT
    reason: Primary site of 14-3-3 zeta adapter activity; core localization.
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IPI
  original_reference_id: PMID:10102273
  review:
    summary: 14-3-3 zeta binds many phosphorylated kinases (RAF1, AKT1, MARK3, DAPK2) as clients; useful context but a generic partner-class term rather than the core adapter MF.
    action: KEEP_AS_NON_CORE
    reason: Specific-partner-class binding; subsumed by phospho-motif adapter activity.
    supported_by:
    - reference_id: PMID:10102273
      supporting_text: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10026197
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:10026197
      supporting_text: Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12176995
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:12176995
      supporting_text: 2002 Aug 9. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21081150
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:21081150
      supporting_text: Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19172738
  review:
    summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms.
    action: MARK_AS_OVER_ANNOTATED
    reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515.
    supported_by:
    - reference_id: PMID:19172738
      supporting_text: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: TAS
  original_reference_id: PMID:16130169
  review:
    summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS).
    action: ACCEPT
    reason: Core cytoplasmic localization of the adapter.
    supported_by:
    - reference_id: PMID:16130169
      supporting_text: Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: TAS
  original_reference_id: PMID:16130169
  review:
    summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS).
    action: ACCEPT
    reason: Adapter coupling of phospho-clients is the core signaling role.
    supported_by:
    - reference_id: PMID:16130169
      supporting_text: Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
- term:
    id: GO:0043066
    label: negative regulation of apoptotic process
  evidence_type: TAS
  original_reference_id: PMID:16130169
  review:
    summary: 14-3-3 zeta promotes survival by sequestering pro-apoptotic clients (phospho-BAX, BAD, ABL1) in the cytoplasm; a downstream consequence of adapter binding (PMID:15071501).
    action: KEEP_AS_NON_CORE
    reason: Pleiotropic survival output of client sequestration; non-core.
    supported_by:
    - reference_id: PMID:16130169
      supporting_text: Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
core_functions:
- molecular_function:
    id: GO:0042802
    label: identical protein binding
  description: >-
    YWHAZ forms homodimers as obligate functional units. The dimeric W-shaped
    architecture presents two peptide-binding grooves that can simultaneously
    engage two phosphomotifs, either on the same client or bridging two clients.
    Homodimerization is regulated by phosphorylation at Ser-58.
  directly_involved_in:
  - id: GO:0008104
    label: intracellular protein localization
  - id: GO:0007165
    label: signal transduction
  locations:
  - id: GO:0005737
    label: cytoplasm
  supported_by: *id001
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: PMID:10026197
  title: Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.
  findings: []
- id: PMID:10102273
  title: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
  findings: []
- id: PMID:10642536
  title: 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor.
  findings: []
- id: PMID:10713667
  title: Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase.
  findings: []
- id: PMID:10840038
  title: 14-3-3zeta is an effector of tau protein phosphorylation.
  findings: []
- id: PMID:10887173
  title: Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo.
  findings: []
- id: PMID:11237865
  title: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
  findings: []
- id: PMID:11336675
  title: Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
  findings: []
- id: PMID:11504882
  title: Differential localization of HDAC4 orchestrates muscle differentiation.
  findings: []
- id: PMID:11526496
  title: The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3.
  findings: []
- id: PMID:11697890
  title: Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
  findings: []
- id: PMID:11723239
  title: 14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
  findings: []
- id: PMID:11864996
  title: 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
  findings: []
- id: PMID:12154078
  title: Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
  findings: []
- id: PMID:12176984
  title: Identification and characterization of the interaction between tuberin and 14-3-3zeta.
  findings: []
- id: PMID:12176995
  title: MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
  findings: []
- id: PMID:12361576
  title: 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
  findings: []
- id: PMID:12383250
  title: A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo.
  findings: []
- id: PMID:12438239
  title: 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
  findings: []
- id: PMID:12468542
  title: 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
  findings: []
- id: PMID:12589811
  title: 'The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.'
  findings: []
- id: PMID:12615066
  title: Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins.
  findings: []
- id: PMID:12757707
  title: Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
  findings: []
- id: PMID:12764136
  title: 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity.
  findings: []
- id: PMID:12766774
  title: Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
  findings: []
- id: PMID:12819209
  title: Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
  findings: []
- id: PMID:12941695
  title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
  findings: []
- id: PMID:12944463
  title: Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
  findings: []
- id: PMID:12963375
  title: 'Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.'
  findings: []
- id: PMID:14676191
  title: Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
  findings: []
- id: PMID:14688280
  title: 'Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.'
  findings: []
- id: PMID:14743216
  title: A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
  findings: []
- id: PMID:14970201
  title: p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
  findings: []
- id: PMID:15023544
  title: Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.
  findings: []
- id: PMID:15037601
  title: YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
  findings: []
- id: PMID:15161933
  title: Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
  findings: []
- id: PMID:15225635
  title: Identification of 14-3-3zeta as an EGF receptor interacting protein.
  findings: []
- id: PMID:15314064
  title: Raf-1 activation disrupts its binding to keratins during cell stress.
  findings: []
- id: PMID:15324659
  title: aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
  findings: []
- id: PMID:15324660
  title: Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
  findings: []
- id: PMID:15629715
  title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
  findings: []
- id: PMID:15657067
  title: Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
  findings: []
- id: PMID:15696159
  title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
  findings: []
- id: PMID:15964851
  title: Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.
  findings: []
- id: PMID:16114898
  title: 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.
  findings: []
- id: PMID:16130169
  title: Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
  findings: []
- id: PMID:16246723
  title: Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
  findings: []
- id: PMID:16306228
  title: 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
  findings: []
- id: PMID:16376338
  title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
  findings: []
- id: PMID:16449798
  title: Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.
  findings: []
- id: PMID:16502470
  title: 'Human colostrum: identification of minor proteins in the aqueous phase by proteomics.'
  findings: []
- id: PMID:16511560
  title: Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
  findings: []
- id: PMID:16636147
  title: Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
  findings: []
- id: PMID:16672277
  title: Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding.
  findings: []
- id: PMID:16868027
  title: Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.
  findings: []
- id: PMID:16959763
  title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
  findings: []
- id: PMID:17043677
  title: 'Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.'
  findings: []
- id: PMID:17166838
  title: 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
  findings: []
- id: PMID:17317006
  title: 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
  findings: []
- id: PMID:17353931
  title: Large-scale mapping of human protein-protein interactions by mass spectrometry.
  findings: []
- id: PMID:17979178
  title: A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
  findings: []
- id: PMID:18029012
  title: Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.
  findings: []
- id: PMID:18418070
  title: Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns.
  findings: []
- id: PMID:18439900
  title: AMPK phosphorylation of raptor mediates a metabolic checkpoint.
  findings: []
- id: PMID:18573912
  title: Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.
  findings: []
- id: PMID:18647389
  title: The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
  findings: []
- id: PMID:19049963
  title: 'Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.'
  findings: []
- id: PMID:19056867
  title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  findings: []
- id: PMID:19138662
  title: Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta.
  findings: []
- id: PMID:19172738
  title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
  findings: []
- id: PMID:19190083
  title: 'Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.'
  findings: []
- id: PMID:19199708
  title: Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
  findings: []
- id: PMID:19357195
  title: Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.
  findings: []
- id: PMID:19481529
  title: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
  findings: []
- id: PMID:19647741
  title: Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta.
  findings: []
- id: PMID:19662078
  title: Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
  findings: []
- id: PMID:19667065
  title: 'Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.'
  findings: []
- id: PMID:19720745
  title: Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.
  findings: []
- id: PMID:19725078
  title: Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
  findings: []
- id: PMID:19732720
  title: 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
  findings: []
- id: PMID:19766566
  title: Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
  findings: []
- id: PMID:19860830
  title: The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent.
  findings: []
- id: PMID:19933840
  title: Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
  findings: []
- id: PMID:19940019
  title: Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.
  findings: []
- id: PMID:20037628
  title: Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.
  findings: []
- id: PMID:20052757
  title: 'Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.'
  findings: []
- id: PMID:20224040
  title: Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin.
  findings: []
- id: PMID:20332113
  title: CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
  findings: []
- id: PMID:20451386
  title: Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.
  findings: []
- id: PMID:20458337
  title: MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
  findings: []
- id: PMID:20603015
  title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
  findings: []
- id: PMID:20618440
  title: Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
  findings: []
- id: PMID:20642453
  title: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
  findings: []
- id: PMID:20679480
  title: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
  findings: []
- id: PMID:20936779
  title: A human MAP kinase interactome.
  findings: []
- id: PMID:21081150
  title: Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.
  findings: []
- id: PMID:21182262
  title: 'Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.'
  findings: []
- id: PMID:21282530
  title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
  findings: []
- id: PMID:21423176
  title: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
  findings: []
- id: PMID:21554249
  title: 'NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.'
  findings: []
- id: PMID:21621563
  title: Bimodal regulation of FoxO3 by AKT and 14-3-3.
  findings: []
- id: PMID:21630459
  title: Proteomic characterization of the human sperm nucleus.
  findings: []
- id: PMID:21988832
  title: Toward an understanding of the protein interaction network of the human liver.
  findings: []
- id: PMID:22516433
  title: Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
  findings: []
- id: PMID:22575644
  title: 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.
  findings: []
- id: PMID:22580824
  title: ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.
  findings: []
- id: PMID:22653443
  title: Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
  findings: []
- id: PMID:22658674
  title: Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
  findings: []
- id: PMID:23075850
  title: Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
  findings: []
- id: PMID:23397142
  title: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
  findings: []
- id: PMID:23414517
  title: 'A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.'
  findings: []
- id: PMID:23455924
  title: A Y2H-seq approach defines the human protein methyltransferase interactome.
  findings: []
- id: PMID:23533145
  title: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
  findings: []
- id: PMID:23572552
  title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
  findings: []
- id: PMID:23580065
  title: Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
  findings: []
- id: PMID:23622247
  title: 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
  findings: []
- id: PMID:23752268
  title: The functional interactome landscape of the human histone deacetylase family.
  findings: []
- id: PMID:24255178
  title: Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
  findings: []
- id: PMID:24351927
  title: Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
  findings: []
- id: PMID:24510904
  title: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
  findings: []
- id: PMID:24658140
  title: The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
  findings: []
- id: PMID:24947832
  title: Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
  findings: []
- id: PMID:25189701
  title: A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.
  findings: []
- id: PMID:25277244
  title: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
  findings: []
- id: PMID:25468996
  title: E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
  findings: []
- id: PMID:25670079
  title: 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
  findings: []
- id: PMID:25852190
  title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
  findings: []
- id: PMID:25959826
  title: Quantitative interaction proteomics of neurodegenerative disease proteins.
  findings: []
- id: PMID:26496610
  title: A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
  findings: []
- id: PMID:27030597
  title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.
  findings: []
- id: PMID:27291054
  title: Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells.
  findings: []
- id: PMID:27880917
  title: Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
  findings: []
- id: PMID:28330616
  title: Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
  findings: []
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and disease networks.
  findings: []
- id: PMID:28575131
  title: Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction.
  findings: []
- id: PMID:29100370
  title: Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization.
  findings: []
- id: PMID:29408703
  title: Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).
  findings: []
- id: PMID:31024343
  title: A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
  findings: []
- id: PMID:31046837
  title: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
  findings: []
- id: PMID:31413325
  title: HENA, heterogeneous network-based data set for Alzheimer's disease.
  findings: []
- id: PMID:31906564
  title: Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle.
  findings: []
- id: PMID:31980649
  title: Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32707033
  title: Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
  findings: []
- id: PMID:32814053
  title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
  findings: []
- id: PMID:34927784
  title: ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:35512704
  title: Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
  findings: []
- id: PMID:35662396
  title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
  findings: []
- id: PMID:36096339
  title: Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
  findings: []
- id: PMID:36931259
  title: A central chaperone-like role for 14-3-3 proteins in human cells.
  findings: []
- id: PMID:37045861
  title: Interactome dynamics of RAF1-BRAF kinase monomers and dimers.
  findings: []
- id: PMID:37776851
  title: Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
  findings: []
- id: PMID:39251607
  title: Systematic identification of post-transcriptional regulatory modules.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: PMID:7935795
  title: Activation of Raf-1 by 14-3-3 proteins.
  findings: []
- id: PMID:7939632
  title: Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
  findings: []
- id: PMID:8085158
  title: Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.
  findings: []
- id: PMID:8601312
  title: Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
  findings: []
- id: PMID:9153224
  title: Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
  findings: []
- id: PMID:9543386
  title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
  findings: []
- id: Reactome:R-HSA-139899
  title: Sequestration of BAD protein by 14-3-3
  findings: []
- id: Reactome:R-HSA-139906
  title: Activation of BAD by calcineurin
  findings: []
- id: Reactome:R-HSA-3769391
  title: XPO1 binds the beta-catenin:CBY complex
  findings: []
- id: Reactome:R-HSA-3769392
  title: YWHAZ and XPO1 mediate the nuclear export of beta-catenin
  findings: []
- id: Reactome:R-HSA-3769393
  title: YWHAZ binds p-CBY:CTNNB1
  findings: []
- id: Reactome:R-HSA-430073
  title: GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
  findings: []
- id: Reactome:R-HSA-430076
  title: GP1b-IX-V binds 14-3-3-zeta
  findings: []
- id: Reactome:R-HSA-443402
  title: GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
  findings: []
- id: Reactome:R-HSA-443831
  title: 14-3-3-zeta binds Raf1
  findings: []
- id: Reactome:R-HSA-450620
  title: p-S193-KSRP binds 14-3-3zeta in the nucleus
  findings: []
- id: Reactome:R-HSA-5632732
  title: p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
  findings: []
- id: Reactome:R-HSA-5632738
  title: DDIT4 binds 14-3-3 dimer
  findings: []
- id: Reactome:R-HSA-75016
  title: Association of p-S216-CDC25C with 14-3-3 proteins
  findings: []
- id: Reactome:R-HSA-912757
  title: p-S585-IL3RB binds 14-3-3 proteins
  findings: []
- id: Reactome:R-HSA-913993
  title: 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
  findings: []
- id: Reactome:R-HSA-914182
  title: 14-3-3 zeta binding allows recruitment of PI3K
  findings: []
- id: Reactome:R-HSA-9614423
  title: 14-3-3 proteins bind AKT-phosphorylated FOXO1
  findings: []
- id: Reactome:R-HSA-9614562
  title: 14-3-3 proteins bind AKT-phosphorylated FOXO3
  findings: []
- id: Reactome:R-HSA-9614564
  title: 14-3-3 proteins bind AKT-phosphorylated FOXO4
  findings: []
- id: Reactome:R-HSA-9727919
  title: SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins
  findings: []
- id: Reactome:R-HSA-9729500
  title: SARS-CoV-2 N binds to 14-3-3 proteins
  findings: []