14-3-3 protein zeta/delta (YWHAZ) is an adapter protein that functions as a dimeric scaffold recognizing phosphoserine/phosphothreonine motifs in client proteins. The core molecular function is phosphoserine/phosphothreonine-dependent protein binding within a conserved amphipathic groove formed by helices C/E/G/I. YWHAZ forms homodimers and heterodimers (notably with YWHAE) and primarily localizes to the cytosol, though it can shuttle to the nucleus with certain clients. Key functional roles include: (1) cytoplasmic sequestration of transcription factors (FOXO family, YAP/TAZ, TFEB); (2) regulation of RAF/MEK/ERK MAPK signaling by scaffolding RAF kinases; (3) modulation of PI3K-AKT pathway through BAD sequestration and regulation of mTORC1 via raptor binding; (4) regulation of cell cycle checkpoints via CDC25 phosphatase binding; (5) protein stabilization through chaperone-like activity. The protein binds hundreds of client proteins in a phosphorylation-dependent manner via canonical Mode I (RSXpSXP), Mode II (RXY/FXpSXP), and Mode III (C-terminal pS/pT) motifs.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS). Reason: Core cytoplasmic localization of the adapter. |
| GO:0008104 intracellular protein localization | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA-inferred role in positioning client proteins; a generic restatement of the localization control achieved through phospho-client binding. Reason: Generic IBA localization-control process; subsumed by sequestration. |
| GO:0007165 signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS). Reason: Adapter coupling of phospho-clients is the core signaling role. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS). Reason: Core cytoplasmic localization of the adapter. |
| GO:0042470 melanosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Detected in melanosome proteomes (PMID:17081065); an organelle-association from large-scale profiling rather than a defining site of function. Reason: Proteomic organelle association; non-core localization. |
| GO:0042802 identical protein binding | IEA GO_REF:0000117 | ACCEPT | Summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338). Reason: Homodimerization is structurally core, not generic protein binding. |
| GO:0005515 protein binding | IPI PMID:10102273 Akt promotes cell survival by phosphorylating and inhibiting... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:10102273 Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3 proteins and FKHRL1's retention in the cytoplasm. |
| GO:0005515 protein binding | IPI PMID:10642536 14-3-3zeta interacts with the alpha-chain of human interleuk... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:10642536 We have identified 14-3-3zeta as an hIL-9Ralpha-interacting protein. We also mapped residues 518-522 (Arg-Ser(519)-Trp-Thr(521)-Phe) in hIL-9Ralpha and helix I of 14-3-3zeta as being important for interaction. |
| GO:0005515 protein binding | IPI PMID:10713667 Specific interaction between 14-3-3 isoforms and the human C... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:10840038 14-3-3zeta is an effector of tau protein phosphorylation. | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:10887173 Calyculin A-induced vimentin phosphorylation sequesters 14-3... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:11237865 Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphoryla... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:11336675 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransf... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:11336675 AANAT is bound in the central channel of the 14-3-3zeta dimer, and is held in place by extensive interactions both with the amphipathic phosphopeptide binding groove of 14-3-3zeta and with other parts of the central channel. |
| GO:0005515 protein binding | IPI PMID:11504882 Differential localization of HDAC4 orchestrates muscle diffe... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:11526496 The growth-promoting activity of the Bad protein in chicken ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. |
| GO:0005515 protein binding | IPI PMID:11697890 Functional conservation of 14-3-3 isoforms in inhibiting bad... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:11697890 Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis. |
| GO:0005515 protein binding | IPI PMID:11723239 14-3-3 inhibits Bad-induced cell death through interaction w... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:11723239 14-3-3 inhibits Bad-induced cell death through interaction with serine-136. |
| GO:0005515 protein binding | IPI PMID:11864996 14-3-3 transits to the nucleus and participates in dynamic n... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:11864996 Feb 25. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. |
| GO:0005515 protein binding | IPI PMID:12154078 Regulation of the CDK-related protein kinase PCTAIRE-1 and i... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12154078 Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. |
| GO:0005515 protein binding | IPI PMID:12176984 Identification and characterization of the interaction betwe... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12176984 2002 Aug 9. Identification and characterization of the interaction between tuberin and 14-3-3zeta. |
| GO:0005515 protein binding | IPI PMID:12361576 14-3-3 regulates actin dynamics by stabilizing phosphorylate... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12361576 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. |
| GO:0005515 protein binding | IPI PMID:12383250 A nonphosphorylated 14-3-3 binding motif on exoenzyme S that... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12383250 A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo. |
| GO:0005515 protein binding | IPI PMID:12438239 14-3-3 interacts with the tumor suppressor tuberin at Akt ph... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12438239 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). |
| GO:0005515 protein binding | IPI PMID:12468542 14-3-3beta binds to and negatively regulates the tuberous sc... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12468542 2002 Dec 4. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. |
| GO:0005515 protein binding | IPI PMID:12589811 The interaction between ADAM 22 and 14-3-3zeta: regulation o... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12589811 The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. |
| GO:0005515 protein binding | IPI PMID:12615066 Characterization of zetin 1/rBSPRY, a novel binding partner ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12615066 Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:12757707 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 media... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12757707 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. |
| GO:0005515 protein binding | IPI PMID:12764136 14-3-3 acts as an intramolecular bridge to regulate cdc25B l... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12764136 2003 May 22. 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity. |
| GO:0005515 protein binding | IPI PMID:12766774 Dual phosphorylation controls Cdc25 phosphatases and mitotic... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12766774 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. |
| GO:0005515 protein binding | IPI PMID:12819209 Threonine 391 phosphorylation of the human prolactin recepto... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12819209 2003 Jun 20. Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:12941695 Functional analysis of C-TAK1 substrate binding and identifi... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12941695 Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. |
| GO:0005515 protein binding | IPI PMID:12944463 Protein phosphatase 2A dephosphorylation of phosphoserine 11... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12944463 Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. |
| GO:0005515 protein binding | IPI PMID:12963375 Alternative splicing as a mechanism for regulating 14-3-3 bi... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12963375 Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:14676191 Comprehensive proteomic analysis of human Par protein comple... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:14676191 2003 Dec 15. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |
| GO:0005515 protein binding | IPI PMID:14688280 Dynamic changes in C-Raf phosphorylation and 14-3-3 protein ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:14688280 2003 Dec 19. Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites. |
| GO:0005515 protein binding | IPI PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kapp... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:14743216 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |
| GO:0005515 protein binding | IPI PMID:14970201 p21-activated kinase 1 phosphorylates and regulates 14-3-3 b... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:14970201 2004 Feb 17. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. |
| GO:0005515 protein binding | IPI PMID:15023544 Interaction of apoptosis signal-regulating kinase 1 with iso... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15023544 Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:15037601 YSK1 is activated by the Golgi matrix protein GM130 and play... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15037601 Mar 22. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. |
| GO:0005515 protein binding | IPI PMID:15161933 Comprehensive proteomic analysis of interphase and mitotic 1... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15161933 2004 May 25. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. |
| GO:0005515 protein binding | IPI PMID:15225635 Identification of 14-3-3zeta as an EGF receptor interacting ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15225635 Identification of 14-3-3zeta as an EGF receptor interacting protein. |
| GO:0005515 protein binding | IPI PMID:15314064 Raf-1 activation disrupts its binding to keratins during cel... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15314064 Raf-1 activation disrupts its binding to keratins during cell stress. |
| GO:0005515 protein binding | IPI PMID:15324659 aPKC acts upstream of PAR-1b in both the establishment and m... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15324659 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. |
| GO:0005515 protein binding | IPI PMID:15324660 Proteomic, functional, and domain-based analysis of in vivo ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15324660 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |
| GO:0005515 protein binding | IPI PMID:15629715 MAPKAP kinase-2 is a cell cycle checkpoint kinase that regul... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15629715 MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. |
| GO:0005515 protein binding | IPI PMID:15657067 Phosphotyrosine signaling networks in epidermal growth facto... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15657067 Epub 2005 Jan 17. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. |
| GO:0005515 protein binding | IPI PMID:15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear tar... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:15964851 Identification of the ankyrin repeat proteins ANKRA and RFXA... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:15964851 2005 Jun 17. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. |
| GO:0005515 protein binding | IPI PMID:16246723 Molecular basis for the recognition of phosphorylated and ph... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16246723 Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. |
| GO:0005515 protein binding | IPI PMID:16306228 14-3-3 cooperates with LKB1 to regulate the activity and loc... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16306228 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. |
| GO:0005515 protein binding | IPI PMID:16376338 Protein kinase A phosphorylates and regulates dimerization o... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16376338 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. |
| GO:0005515 protein binding | IPI PMID:16449798 Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MA... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16449798 Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. |
| GO:0005515 protein binding | IPI PMID:16511560 Regulation of MDMX nuclear import and degradation by Chk2 an... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16511560 Mar 2. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. |
| GO:0005515 protein binding | IPI PMID:16636147 Activity of TSC2 is inhibited by AKT-mediated phosphorylatio... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16636147 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. |
| GO:0005515 protein binding | IPI PMID:16672277 Amino acids C-terminal to the 14-3-3 binding motif in CDC25B... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16672277 Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding. |
| GO:0005515 protein binding | IPI PMID:16868027 Efficient ADAM22 surface expression is mediated by phosphory... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16868027 Jul 25. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. |
| GO:0005515 protein binding | IPI PMID:16959763 Transgenic mouse proteomics identifies new 14-3-3-associated... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:16959763 Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. |
| GO:0005515 protein binding | IPI PMID:17043677 Disrupted in Schizophrenia 1 Interactome: evidence for the c... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:17043677 Oct 17. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. |
| GO:0005515 protein binding | IPI PMID:17166838 14-3-3 protein interacts with Huntingtin-associated protein ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:17166838 2006 Dec 13. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. |
| GO:0005515 protein binding | IPI PMID:17317006 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylatio... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:17317006 Epub 2007 Feb 3. 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9. |
| GO:0005515 protein binding | IPI PMID:17353931 Large-scale mapping of human protein-protein interactions by... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:17353931 Large-scale mapping of human protein-protein interactions by mass spectrometry. |
| GO:0005515 protein binding | IPI PMID:17979178 A novel tandem affinity purification strategy for the effici... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:17979178 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. |
| GO:0005515 protein binding | IPI PMID:18418070 Modulation of 14-3-3 interaction with phosphorylated histone... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:18418070 Mar 11. Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns. |
| GO:0005515 protein binding | IPI PMID:18573912 Chibby cooperates with 14-3-3 to regulate beta-catenin subce... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:18573912 Jun 23. Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity. |
| GO:0005515 protein binding | IPI PMID:18647389 The central proline rich region of POB1/REPS2 plays a regula... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:18647389 The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins. |
| GO:0005515 protein binding | IPI PMID:19049963 Regulation of RAF activity by 14-3-3 proteins: RAF kinases a... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19049963 2008 Dec 2. Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:19138662 Effect of phosphorylation on interaction of human tau protei... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19138662 Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta. |
| GO:0005515 protein binding | IPI PMID:19357195 Shear stress induced reorganization of the keratin intermedi... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19357195 2009 Apr 8. Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta. |
| GO:0005515 protein binding | IPI PMID:19481529 Akt and 14-3-3 control a PACS-2 homeostatic switch that inte... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19481529 Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. |
| GO:0005515 protein binding | IPI PMID:19647741 Phosphorylation of more than one site is required for tight ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19647741 Epub 2009 Aug 3. Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta. |
| GO:0005515 protein binding | IPI PMID:19662078 Recognition of an intra-chain tandem 14-3-3 binding site wit... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19662078 Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. |
| GO:0005515 protein binding | IPI PMID:19667065 Identification of novel in vivo phosphorylation sites of the... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19667065 Epub 2009 Aug 10. Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. |
| GO:0005515 protein binding | IPI PMID:19720745 Characterization of Rictor phosphorylation sites reveals dir... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19720745 Aug 31. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. |
| GO:0005515 protein binding | IPI PMID:19732720 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19732720 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. |
| GO:0005515 protein binding | IPI PMID:19766566 Histone crosstalk between H3S10ph and H4K16ac generates a hi... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19766566 Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. |
| GO:0005515 protein binding | IPI PMID:19860830 The interaction between casein kinase Ialpha and 14-3-3 is p... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19860830 2009 Oct 27. The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent. |
| GO:0005515 protein binding | IPI PMID:19933840 Regulation of IRSp53-dependent filopodial dynamics by antago... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19933840 Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. |
| GO:0005515 protein binding | IPI PMID:19940019 Nuclear-cytoplasmic shuttling of Chibby controls beta-cateni... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19940019 2009 Nov 25. Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. |
| GO:0005515 protein binding | IPI PMID:20037628 Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20037628 Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors. |
| GO:0005515 protein binding | IPI PMID:20052757 Molecular and clinical analysis of RAF1 in Noonan syndrome a... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20052757 Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. |
| GO:0005515 protein binding | IPI PMID:20224040 Histone deacetylase 7 controls endothelial cell growth throu... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20224040 2010 Mar 11. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. |
| GO:0005515 protein binding | IPI PMID:20451386 Aurora B and 14-3-3 coordinately regulate clustering of cent... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20451386 2010 May 6. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. |
| GO:0005515 protein binding | IPI PMID:20603015 Identification of KIAA1018/FAN1, a DNA repair nuclease recru... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20603015 Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. |
| GO:0005515 protein binding | IPI PMID:20618440 Proteomic and biochemical analysis of 14-3-3-binding protein... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20618440 2010 Jul 8. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. |
| GO:0005515 protein binding | IPI PMID:20642453 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20642453 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. |
| GO:0005515 protein binding | IPI PMID:20679480 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome sugge... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20679480 Aug 2. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:20936779 A human MAP kinase interactome. |
| GO:0005515 protein binding | IPI PMID:21282530 Interaction proteomics analysis of polycomb proteins defines... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:21282530 Epub 2011 Jan 31. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:21988832 Toward an understanding of the protein interaction network of the human liver. |
| GO:0005515 protein binding | IPI PMID:22575644 14-3-3 interacts with LKB1 via recognizing phosphorylated th... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:22575644 2012 Mar 23. 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function. |
| GO:0005515 protein binding | IPI PMID:22580824 ARF6 GTPase protects the post-mitotic midbody from 14-3-3-me... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:22580824 ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration. |
| GO:0005515 protein binding | IPI PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-s... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:22653443 Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. |
| GO:0005515 protein binding | IPI PMID:23075850 Progressive degeneration of human neural stem cells caused b... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23075850 Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. |
| GO:0005515 protein binding | IPI PMID:23397142 Analysis of protein-protein interactions in cross-talk pathw... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23397142 Epub 2013 Feb 8. Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. |
| GO:0005515 protein binding | IPI PMID:23414517 A human skeletal muscle interactome centered on proteins inv... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23414517 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. |
| GO:0005515 protein binding | IPI PMID:23455924 A Y2H-seq approach defines the human protein methyltransfera... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23455924 A Y2H-seq approach defines the human protein methyltransferase interactome. |
| GO:0005515 protein binding | IPI PMID:23622247 14-3-3 proteins interact with a hybrid prenyl-phosphorylatio... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23622247 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. |
| GO:0005515 protein binding | IPI PMID:23752268 The functional interactome landscape of the human histone de... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23752268 The functional interactome landscape of the human histone deacetylase family. |
| GO:0005515 protein binding | IPI PMID:24255178 Protein interaction network of the mammalian Hippo pathway r... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:24255178 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. |
| GO:0005515 protein binding | IPI PMID:24351927 Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phos... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:24351927 Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. |
| GO:0005515 protein binding | IPI PMID:24510904 Unbiased screen for interactors of leucine-rich repeat kinas... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:24510904 Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. |
| GO:0005515 protein binding | IPI PMID:24947832 Differential protein-protein interactions of LRRK1 and LRRK2... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:24947832 Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:25277244 Epub 2014 Oct 2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. |
| GO:0005515 protein binding | IPI PMID:25670079 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to meta... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:25670079 14-3-3ΞΆ turns TGF-Ξ²'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. |
| GO:0005515 protein binding | IPI PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apo... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. |
| GO:0005515 protein binding | IPI PMID:25959826 Quantitative interaction proteomics of neurodegenerative dis... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:25959826 2015 May 7. Quantitative interaction proteomics of neurodegenerative disease proteins. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:26496610 Oct 22. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
| GO:0005515 protein binding | IPI PMID:27291054 Isolation of Functional Tubulin Dimers and of Tubulin-Associ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:27291054 2016 Jun 9. Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells. |
| GO:0005515 protein binding | IPI PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatas... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:27880917 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. |
| GO:0005515 protein binding | IPI PMID:28330616 Systematic Analysis of Human Protein Phosphatase Interaction... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:28330616 2017 Mar 18. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:28514442 Architecture of the human interactome defines protein communities and disease networks. |
| GO:0005515 protein binding | IPI PMID:28575131 Bacterial co-expression of human Tau protein with protein ki... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:28575131 eCollection 2017. Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction. |
| GO:0005515 protein binding | IPI PMID:29100370 Identification of the PAK4 interactome reveals PAK4 phosphor... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:29100370 eCollection 2017 Sep 29. |
| GO:0005515 protein binding | IPI PMID:29408703 Structural characterization of 14-3-3ΞΆ in complex with the h... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:29408703 2018 Feb 1. Structural characterization of 14-3-3ΞΆ in complex with the human Son of sevenless homolog 1 (SOS1). |
| GO:0005515 protein binding | IPI PMID:31046837 Parkinson's disease-associated LRRK2-G2019S mutant acts thro... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:31046837 Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes. |
| GO:0005515 protein binding | IPI PMID:31413325 HENA, heterogeneous network-based data set for Alzheimer's d... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:31413325 HENA, heterogeneous network-based data set for Alzheimer's disease. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:32296183 Apr 8. A reference map of the human binary protein interactome. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:32707033 2020 Jul 23. Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:34927784 ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activato... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:34927784 ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:35271311 2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:35512704 2022 May 4. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. |
| GO:0005515 protein binding | IPI PMID:36096339 Cytosolic sequestration of spatacsin by Protein Kinase A and... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:36096339 Sep 9. Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human cells. |
| GO:0005515 protein binding | IPI PMID:37045861 Interactome dynamics of RAF1-BRAF kinase monomers and dimers... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:37045861 Interactome dynamics of RAF1-BRAF kinase monomers and dimers. |
| GO:0005515 protein binding | IPI PMID:37776851 Analysis of proteome-wide degradation dynamics in ALS SOD1 i... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:37776851 2023 Sep 29. Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis. |
| GO:0005515 protein binding | IPI PMID:39251607 Systematic identification of post-transcriptional regulatory... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:39251607 Systematic identification of post-transcriptional regulatory modules. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:40205054 Apr 9. Multimodal cell maps as a foundation for structural and functional genomics. |
| GO:0005515 protein binding | IPI PMID:7935795 Activation of Raf-1 by 14-3-3 proteins. | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:7935795 Activation of Raf-1 by 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:7939632 Interaction of the protein kinase Raf-1 with 14-3-3 proteins... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:7939632 Interaction of the protein kinase Raf-1 with 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:8085158 Binding of 14-3-3 proteins to the protein kinase Raf and eff... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:8085158 Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. |
| GO:0005515 protein binding | IPI PMID:8601312 Interaction of 14-3-3 with signaling proteins is mediated by... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:8601312 Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. |
| GO:0005515 protein binding | IPI PMID:9153224 Raf-1 kinase and exoenzyme S interact with 14-3-3zeta throug... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:9153224 Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49. |
| GO:0042802 identical protein binding | IPI PMID:16376338 Protein kinase A phosphorylates and regulates dimerization o... | ACCEPT | Summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338). Reason: Homodimerization is structurally core, not generic protein binding. Supporting Evidence: PMID:16376338 2005 Dec 19. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. |
| GO:0042802 identical protein binding | IPI PMID:20618440 Proteomic and biochemical analysis of 14-3-3-binding protein... | ACCEPT | Summary: 14-3-3 zeta forms structurally obligate homodimers (and heterodimers with YWHAE); dimerization, regulated by Ser58 phosphorylation, is required to present two binding grooves (PMID:12865427, PMID:16376338). Reason: Homodimerization is structurally core, not generic protein binding. Supporting Evidence: PMID:20618440 2010 Jul 8. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Indirect transcriptional repression via cytoplasmic retention of TFs and binding of class-IIa HDACs; a downstream consequence rather than a direct DNA/chromatin function (IDA/IEA). Reason: Indirect transcriptional effect of TF sequestration; non-core. |
| GO:0001525 angiogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-projected role in angiogenesis reflecting 14-3-3 zeta's involvement in growth/survival signaling; a broad pleiotropic physiological output. Reason: Broad IEA physiological process; non-core. |
| GO:0003016 respiratory system process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-projected physiological process; a pleiotropic organ-system annotation far removed from the molecular adapter function. Reason: Pleiotropic IEA physiological process; non-core. |
| GO:0005634 nucleus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool. Reason: Secondary nuclear pool; non-core localization. |
| GO:0008039 synaptic target recognition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-inferred role in synaptic target recognition; a specialized neuronal process attributable to 14-3-3 client regulation rather than its core MF. Reason: Specialized IEA neuronal process; non-core. |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000107 | ACCEPT | Summary: 14-3-3 zeta engages defined phospho-motif segments (Mode I/II/III linear motifs) of partner domains rather than binding indiscriminately, the basis of its scaffold function. Reason: Reflects specific motif/domain recognition central to 14-3-3 function. |
| GO:0030324 lung development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-projected developmental role; a pleiotropic organ-development annotation downstream of ubiquitous signaling functions, not a defining role. Reason: Pleiotropic IEA developmental process; non-core. |
| GO:0035148 tube formation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-projected morphogenetic process (e.g. vascular/epithelial tube formation); a broad developmental output of signaling roles, not core. Reason: Broad IEA morphogenetic process; non-core. |
| GO:0098686 hippocampal mossy fiber to CA3 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA electronic localization to a specific hippocampal synapse type; reflects neuronal synaptic roles but is highly specialized and non-core. Reason: Highly specialized IEA synaptic localization; non-core. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IDA PMID:21621563 Bimodal regulation of FoxO3 by AKT and 14-3-3. | KEEP AS NON CORE | Summary: Indirect transcriptional repression via cytoplasmic retention of TFs and binding of class-IIa HDACs; a downstream consequence rather than a direct DNA/chromatin function (IDA/IEA). Reason: Indirect transcriptional effect of TF sequestration; non-core. Supporting Evidence: PMID:21621563 Bimodal regulation of FoxO3 by AKT and 14-3-3. |
| GO:0019903 protein phosphatase binding | IPI PMID:9543386 C-TAK1 protein kinase phosphorylates human Cdc25C on serine ... | KEEP AS NON CORE | Summary: Reflects binding to phosphatase clients such as the cofilin phosphatase Slingshot (SSH1); a partner-class binding, not the defining MF (PMID:15159416, PMID:15660133). Reason: Partner-class binding; corroborating but non-core. Supporting Evidence: PMID:9543386 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. |
| GO:0005634 nucleus | IDA PMID:31906564 Differential Subcellular Distribution and Translocation of S... | KEEP AS NON CORE | Summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool. Reason: Secondary nuclear pool; non-core localization. Supporting Evidence: PMID:31906564 Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle. |
| GO:0005737 cytoplasm | IDA PMID:31906564 Differential Subcellular Distribution and Translocation of S... | ACCEPT | Summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS). Reason: Core cytoplasmic localization of the adapter. Supporting Evidence: PMID:31906564 Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle. |
| GO:0090128 regulation of synapse maturation | IDA PMID:16959763 Transgenic mouse proteomics identifies new 14-3-3-associated... | KEEP AS NON CORE | Summary: 14-3-3 zeta regulates spine/synapse maturation by modulating ARHGEF7 activity on RAC1; a neuron-specific developmental role downstream of adapter binding (IDA/IMP). Reason: Neuron-specific developmental output; non-core. Supporting Evidence: PMID:16959763 Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. |
| GO:0090128 regulation of synapse maturation | IMP PMID:16959763 Transgenic mouse proteomics identifies new 14-3-3-associated... | KEEP AS NON CORE | Summary: 14-3-3 zeta regulates spine/synapse maturation by modulating ARHGEF7 activity on RAC1; a neuron-specific developmental role downstream of adapter binding (IDA/IMP). Reason: Neuron-specific developmental output; non-core. Supporting Evidence: PMID:16959763 Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. |
| GO:0098978 glutamatergic synapse | IDA PMID:16959763 Transgenic mouse proteomics identifies new 14-3-3-associated... | KEEP AS NON CORE | Summary: Synaptic localization tied to 14-3-3 zeta roles in spine/synapse maturation via ARHGEF7; a tissue-specific site rather than its general adapter compartment. Reason: Neuron-specific localization; non-core. Supporting Evidence: PMID:16959763 Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. |
| GO:0098978 glutamatergic synapse | IMP PMID:16959763 Transgenic mouse proteomics identifies new 14-3-3-associated... | KEEP AS NON CORE | Summary: Synaptic localization tied to 14-3-3 zeta roles in spine/synapse maturation via ARHGEF7; a tissue-specific site rather than its general adapter compartment. Reason: Neuron-specific localization; non-core. Supporting Evidence: PMID:16959763 Epub 2006 Sep 6. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. |
| GO:0044325 transmembrane transporter binding | IPI PMID:18029012 Inhibitory interaction of the 14-3-3 proteins with ubiquitou... | KEEP AS NON CORE | Summary: Reflects binding to membrane transporter/channel clients (e.g. ITGB2, ADAM22); a specific partner interaction, not the defining phospho-adapter MF. Reason: Specific partner-class binding; peripheral to core function. Supporting Evidence: PMID:18029012 2007 Oct 29. Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump. |
| GO:1900181 negative regulation of protein localization to nucleus | IDA PMID:35662396 Itaconate is a lysosomal inducer that promotes antibacterial... | KEEP AS NON CORE | Summary: 14-3-3 zeta retains phospho-clients (FOXO, TFEB, ABL1) in the cytoplasm, blocking their nuclear entry; a direct but downstream consequence of sequestration (IDA). Reason: Downstream localization-control output of adapter binding; non-core. Supporting Evidence: PMID:35662396 Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. |
| GO:0042149 cellular response to glucose starvation | IDA PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | KEEP AS NON CORE | Summary: IDA-supported response to glucose starvation, consistent with 14-3-3 zeta integrating metabolic/AMPK-AKT signaling (e.g. TFEB control); a specific stress response, not core MF. Reason: Specific stress-response process; downstream of adapter activity. Supporting Evidence: PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint. |
| GO:0140311 protein sequestering activity | IDA PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | ACCEPT | Summary: Core mechanistic output: by binding phospho-clients (TFEB, BAX, ABL1, FOXO, MLF1) 14-3-3 zeta sequesters them, controlling localization/activation (PMID:35662396, PMID:15071501). Reason: Sequestration is the direct functional consequence of adapter binding; IDA core. Supporting Evidence: PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint. |
| GO:1904262 negative regulation of TORC1 signaling | IDA PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoi... | KEEP AS NON CORE | Summary: 14-3-3 zeta binds TSC2/PRAS40-type clients to modulate mTORC1; a specific pathway-level effect downstream of its adapter activity (IDA). Reason: Specific pathway regulation; downstream of core MF. Supporting Evidence: PMID:18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint. |
| GO:0045824 negative regulation of innate immune response | IDA PMID:35662396 Itaconate is a lysosomal inducer that promotes antibacterial... | KEEP AS NON CORE | Summary: 14-3-3 zeta binds TRIM25 to dampen RIG-I-dependent type-I IFN signaling (exploited by EBV BPLF1); a specific immunoregulatory output (PMID:29357390, PMID:31710640). Reason: Specific immune-pathway regulation; downstream effect. Supporting Evidence: PMID:35662396 Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. |
| GO:0005829 cytosol | IDA PMID:35662396 Itaconate is a lysosomal inducer that promotes antibacterial... | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. Supporting Evidence: PMID:35662396 Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. |
| GO:0050815 phosphoserine residue binding | IDA PMID:35662396 Itaconate is a lysosomal inducer that promotes antibacterial... | ACCEPT | Summary: Directly captures the defining 14-3-3 zeta MF: binding phosphoserine motifs in client proteins. Crystal structures show pSer/pThr coordination in the amphipathic groove (PMID:10488331, PMID:16246723). Reason: Defining phospho-Ser-binding adapter activity; IDA-supported core MF. Supporting Evidence: PMID:35662396 Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. |
| GO:0140311 protein sequestering activity | IDA PMID:35662396 Itaconate is a lysosomal inducer that promotes antibacterial... | ACCEPT | Summary: Core mechanistic output: by binding phospho-clients (TFEB, BAX, ABL1, FOXO, MLF1) 14-3-3 zeta sequesters them, controlling localization/activation (PMID:35662396, PMID:15071501). Reason: Sequestration is the direct functional consequence of adapter binding; IDA core. Supporting Evidence: PMID:35662396 Epub 2022 Jun 3. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. |
| GO:0031647 regulation of protein stability | EXP PMID:21554249 NMR spectroscopy of 14-3-3ΞΆ reveals a flexible C-terminal ex... | KEEP AS NON CORE | Summary: 14-3-3 zeta binding protects clients such as AANAT from dephosphorylation and proteasomal degradation; a downstream stabilizing effect of adapter binding (EXP, PMID:15644438). Reason: Downstream client-stability effect; non-core. Supporting Evidence: PMID:21554249 NMR spectroscopy of 14-3-3ΞΆ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ΞΆ. |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:16114898 14-3-3 Protein interacts with nuclear localization sequence ... | KEEP AS NON CORE | Summary: 14-3-3 zeta binds phosphorylated transcription factors (TP53, FOXO1/3/4, TFEB) to control their nuclear access; a specific client-class interaction underlying transcriptional regulation (PMID:16114898). Reason: Specific TF-client binding; mechanistic context, not core MF. Supporting Evidence: PMID:16114898 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. |
| GO:0005515 protein binding | IPI PMID:27030597 Familial autoinflammation with neutrophilic dermatosis revea... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:27030597 Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. |
| GO:0006468 protein phosphorylation | IMP PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrom... | MODIFY | Summary: 14-3-3 zeta has no kinase activity; it is phosphorylated by clients (AKT1, CK1, PKA) and regulates kinases. The IMP-supported observation is best recast as regulation of phosphorylation, not catalysis. Reason: 14-3-3 is not a kinase; reframe to regulation of phosphorylation. Proposed replacements: regulation of phosphorylation Supporting Evidence: PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway. |
| GO:0007165 signal transduction | IMP PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrom... | ACCEPT | Summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS). Reason: Adapter coupling of phospho-clients is the core signaling role. Supporting Evidence: PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway. |
| GO:0005515 protein binding | IPI PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrom... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway. |
| GO:0070372 regulation of ERK1 and ERK2 cascade | IDA PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrom... | KEEP AS NON CORE | Summary: By scaffolding phospho-RAF1/BRAF, 14-3-3 zeta tunes RAF-ERK signaling (a YWHAZ CFC-syndrome variant hyperactivates it); a pathway-specific downstream role (PMID:31024343). Reason: Specific MAPK-pathway regulation; downstream consequence. Supporting Evidence: PMID:31024343 A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway. |
| GO:0005515 protein binding | IPI PMID:25189701 A quantitative 14-3-3 interaction screen connects the nuclea... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:25189701 Sep 4. A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response. |
| GO:0045296 cadherin binding | HDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | KEEP AS NON CORE | Summary: High-throughput (HDA) capture of 14-3-3 zeta at cadherin/junctional complexes; a specific partner association rather than its core adapter activity. Reason: Specific HDA partner association; non-core. Supporting Evidence: PMID:25468996 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
| GO:0031982 vesicle | HDA PMID:19190083 Characterization of exosome-like vesicles released from huma... | KEEP AS NON CORE | Summary: HDA vesicle-associated detection, in line with exosome/microparticle capture of abundant cytosolic 14-3-3 zeta; not a defining functional site. Reason: HDA vesicle-fraction capture; non-core localization. Supporting Evidence: PMID:19190083 Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. |
| GO:0005515 protein binding | IPI PMID:21182262 Structural characterization of partially disordered human Ch... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:21182262 Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway. |
| GO:0005515 protein binding | IPI PMID:23572552 ACBD3 interaction with TBC1 domain 22 protein is differentia... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:23572552 ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:19725078 Proteomic analysis of increased Parkin expression and its in... | KEEP AS NON CORE | Summary: Captures binding to E3-ligase clients (e.g. TRIM25, NEDD4-2) where 14-3-3 modulates ligase activity; specific partner-class interaction rather than core MF (PMID:31710640). Reason: Specific partner-class binding; downstream regulatory context. Supporting Evidence: PMID:19725078 Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function. |
| GO:0090168 Golgi reassembly | IMP PMID:20332113 CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi asse... | KEEP AS NON CORE | Summary: IMP-supported role in post-mitotic Golgi reassembly, consistent with 14-3-3 binding trafficking regulators; a specialized trafficking process downstream of adapter activity. Reason: Specialized trafficking process; non-core. Supporting Evidence: PMID:20332113 Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. |
| GO:0051683 establishment of Golgi localization | IMP PMID:20332113 CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi asse... | KEEP AS NON CORE | Summary: IMP-supported contribution to positioning the Golgi, in line with 14-3-3 zeta binding trafficking/cytoskeletal regulators; a specialized downstream process. Reason: Specialized trafficking-positioning process; non-core. Supporting Evidence: PMID:20332113 Mar 23. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | KEEP AS NON CORE | Summary: HDA detection at focal adhesions, consistent with 14-3-3 zeta acting on adhesion/cytoskeletal regulators (ARHGEF2, SSH1); a specific subcellular association, not core. Reason: HDA adhesion-site association; non-core localization. Supporting Evidence: PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ξ²-Pix in negative regulation of focal adhesion maturation. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment. Reason: Abundant-protein exosome capture; non-core localization. Supporting Evidence: PMID:23533145 2013 Apr 23. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| GO:0005615 extracellular space | HDA PMID:16502470 Human colostrum: identification of minor proteins in the aqu... | KEEP AS NON CORE | Summary: HDA extracellular detection, consistent with vesicle-mediated release of this cytosolic adapter rather than a secreted function. Reason: HDA extracellular capture; non-core localization. Supporting Evidence: PMID:16502470 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. |
| GO:0005634 nucleus | HDA PMID:21630459 Proteomic characterization of the human sperm nucleus. | KEEP AS NON CORE | Summary: 14-3-3 zeta is found in the nucleus where it engages TP53, FOXO and histone H3 phosphopeptides; a secondary localization relative to its cytosolic pool. Reason: Secondary nuclear pool; non-core localization. Supporting Evidence: PMID:21630459 Jun 1. Proteomic characterization of the human sperm nucleus. |
| GO:0003723 RNA binding | HDA PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... | MARK AS OVER ANNOTATED | Summary: HDA RNA-interactome capture lists 14-3-3 zeta, but it is a phosphopeptide adapter with no recognized sequence-specific RNA-binding role; likely an indirect/RNP co-capture artifact. Reason: HDA interactome capture; no established direct RNA-binding function. Supporting Evidence: PMID:22658674 May 31. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. |
| GO:0072562 blood microparticle | HDA PMID:22516433 Proteomic analysis of microvesicles from plasma of healthy d... | KEEP AS NON CORE | Summary: HDA detection in blood microparticles reflects abundance/release of this cytosolic protein into extracellular vesicles, not an intrinsic functional site. Reason: Extracellular-vesicle proteomic capture; non-core. Supporting Evidence: PMID:22516433 Epub 2012 Apr 10. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. |
| GO:0005615 extracellular space | HDA PMID:23580065 Shotgun proteomics reveals specific modulated protein patter... | KEEP AS NON CORE | Summary: HDA extracellular detection, consistent with vesicle-mediated release of this cytosolic adapter rather than a secreted function. Reason: HDA extracellular capture; non-core localization. Supporting Evidence: PMID:23580065 Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naΓ―ve to therapy. |
| GO:0070062 extracellular exosome | HDA PMID:19199708 Proteomic analysis of human parotid gland exosomes by multid... | KEEP AS NON CORE | Summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment. Reason: Abundant-protein exosome capture; non-core localization. Supporting Evidence: PMID:19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment. Reason: Abundant-protein exosome capture; non-core localization. Supporting Evidence: PMID:19056867 2008 Dec 3. Large-scale proteomics and phosphoproteomics of urinary exosomes. |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | KEEP AS NON CORE | Summary: HDA exosome-proteome detection (4 annotations); 14-3-3 zeta is an abundant cytosolic protein commonly captured in exosomes, not its functional compartment. Reason: Abundant-protein exosome capture; non-core localization. Supporting Evidence: PMID:20458337 2010 May 11. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769391 | KEEP AS NON CORE | Summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site. Reason: Secondary nuclear-compartment localization; non-core. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769392 | KEEP AS NON CORE | Summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site. Reason: Secondary nuclear-compartment localization; non-core. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769393 | KEEP AS NON CORE | Summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site. Reason: Secondary nuclear-compartment localization; non-core. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-450620 | KEEP AS NON CORE | Summary: TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site. Reason: Secondary nuclear-compartment localization; non-core. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139899 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-139906 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3769392 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-430073 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-430076 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-443402 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-443831 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5632732 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5632738 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-75016 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912757 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913993 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-914182 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9614423 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9614562 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9614564 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9727919 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9729500 | ACCEPT | Summary: 14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS). Reason: Primary site of 14-3-3 zeta adapter activity; core localization. |
| GO:0019901 protein kinase binding | IPI PMID:10102273 Akt promotes cell survival by phosphorylating and inhibiting... | KEEP AS NON CORE | Summary: 14-3-3 zeta binds many phosphorylated kinases (RAF1, AKT1, MARK3, DAPK2) as clients; useful context but a generic partner-class term rather than the core adapter MF. Reason: Specific-partner-class binding; subsumed by phospho-motif adapter activity. Supporting Evidence: PMID:10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. |
| GO:0005515 protein binding | IPI PMID:10026197 Cell adhesion regulates the interaction between the docking ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:10026197 Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. |
| GO:0005515 protein binding | IPI PMID:12176995 MADM, a novel adaptor protein that mediates phosphorylation ... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:12176995 2002 Aug 9. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. |
| GO:0005515 protein binding | IPI PMID:21081150 Pore-forming activity of BAD is regulated by specific phosph... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:21081150 Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. |
| GO:0005515 protein binding | IPI PMID:19172738 Phosphorylation-dependent binding of 14-3-3 terminates signa... | MARK AS OVER ANNOTATED | Summary: 139 IPI annotations of bare protein binding reflect 14-3-3 zeta being a hub interactor in interactome screens; the term conveys no specific function and is superseded by the phospho-motif-binding adapter terms. Reason: Textbook generic-interactor over-annotation; uninformative bare GO:0005515. Supporting Evidence: PMID:19172738 Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. |
| GO:0005737 cytoplasm | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | ACCEPT | Summary: Broad cytoplasmic localization consistent with 14-3-3 zeta's role retaining phospho-clients (BAX, ABL1, MLF1) in the cytoplasm; multiply supported (IBA/IDA/IEA/TAS). Reason: Core cytoplasmic localization of the adapter. Supporting Evidence: PMID:16130169 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |
| GO:0007165 signal transduction | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | ACCEPT | Summary: 14-3-3 zeta couples phosphorylated clients into signaling outputs across many pathways; its adapter activity intrinsically functions in signal transduction (IBA/IMP/TAS). Reason: Adapter coupling of phospho-clients is the core signaling role. Supporting Evidence: PMID:16130169 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |
| GO:0043066 negative regulation of apoptotic process | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | KEEP AS NON CORE | Summary: 14-3-3 zeta promotes survival by sequestering pro-apoptotic clients (phospho-BAX, BAD, ABL1) in the cytoplasm; a downstream consequence of adapter binding (PMID:15071501). Reason: Pleiotropic survival output of client sequestration; non-core. Supporting Evidence: PMID:16130169 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |
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