Agtr1a

UniProt ID: P29754
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Agtr1a

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001822 kidney development
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008217 regulation of blood pressure
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038166 angiotensin-activated signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007204 positive regulation of cytosolic calcium ion concentration
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001596 angiotensin type I receptor activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006954 inflammatory response
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004930 G protein-coupled receptor activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004945 angiotensin type II receptor activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007186 G protein-coupled receptor signaling pathway
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019229 regulation of vasoconstriction
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10358057
Cloning and characterization of ATRAP, a novel protein that ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10358057
Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.
GO:0005515 protein binding
IPI
PMID:15757644
The novel angiotensin II type 1 receptor (AT1R)-associated p... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15757644
The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.
GO:0001596 angiotensin type I receptor activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001921 positive regulation of receptor recycling
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002018 renin-angiotensin regulation of aldosterone production
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006885 regulation of pH
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009651 response to salt stress
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014823 response to activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016323 basolateral plasma membrane
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030425 dendrite
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031410 cytoplasmic vesicle
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031748 D1 dopamine receptor binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031968 organelle outer membrane
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032930 positive regulation of superoxide anion generation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038166 angiotensin-activated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042310 vasoconstriction
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042416 dopamine biosynthetic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042756 drinking behavior
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043627 response to estrogen
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045766 positive regulation of angiogenesis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045777 positive regulation of blood pressure
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051412 response to corticosterone
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0055037 recycling endosome
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071549 cellular response to dexamethasone stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905665 positive regulation of calcium ion import across plasma membrane
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990776 response to angiotensin
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042976 activation of Janus kinase activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001596 angiotensin type I receptor activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001596 angiotensin type I receptor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001822 kidney development
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001921 positive regulation of receptor recycling
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002018 renin-angiotensin regulation of aldosterone production
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004945 angiotensin type II receptor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006885 regulation of pH
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007186 G protein-coupled receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007186 G protein-coupled receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007204 positive regulation of cytosolic calcium ion concentration
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007266 Rho protein signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016323 basolateral plasma membrane
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019229 regulation of vasoconstriction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019722 calcium-mediated signaling
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030425 dendrite
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031410 cytoplasmic vesicle
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031711 bradykinin receptor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031748 D1 dopamine receptor binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031968 organelle outer membrane
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032930 positive regulation of superoxide anion generation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038166 angiotensin-activated signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038166 angiotensin-activated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042310 vasoconstriction
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042416 dopamine biosynthetic process
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042756 drinking behavior
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043627 response to estrogen
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045766 positive regulation of angiogenesis
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045777 positive regulation of blood pressure
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046718 symbiont entry into host cell
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046982 protein heterodimerization activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0055037 recycling endosome
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060326 cell chemotaxis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071549 cellular response to dexamethasone stimulus
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090205 positive regulation of cholesterol metabolic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905665 positive regulation of calcium ion import across plasma membrane
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010467 gene expression
IMP
PMID:24206662
Mineralocorticoid receptor phosphorylation regulates ligand ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24206662
Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.
GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008217 regulation of blood pressure
IMP
PMID:26531127
Age-dependent blood pressure elevation is due to increased v... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26531127
Nov 3. Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.
GO:0006954 inflammatory response
IGI
PMID:19404405
Angiotensin-(1-7) and the g protein-coupled receptor MAS are... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19404405
Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation.
GO:0034391 regulation of smooth muscle cell apoptotic process
IGI
PMID:19508861
The heterogenous nuclear riboprotein S1-1 regulates AT1 rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19508861
Epub 2009 Jun 7. The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
GO:0034392 negative regulation of smooth muscle cell apoptotic process
IMP
PMID:19508861
The heterogenous nuclear riboprotein S1-1 regulates AT1 rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19508861
Epub 2009 Jun 7. The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
GO:0008284 positive regulation of cell population proliferation
IMP
PMID:19508861
The heterogenous nuclear riboprotein S1-1 regulates AT1 rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19508861
Epub 2009 Jun 7. The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
GO:0002035 brain renin-angiotensin system
IMP
PMID:16585392
Role of p90 ribosomal S6 kinase-mediated prorenin-converting... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16585392
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
GO:0007507 heart development
IMP
PMID:16585392
Role of p90 ribosomal S6 kinase-mediated prorenin-converting... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16585392
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
GO:0001819 positive regulation of cytokine production
IMP
PMID:19023134
Serotonin and angiotensin receptors in cardiac fibroblasts c... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19023134
2008 Nov 20. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.
GO:0045777 positive regulation of blood pressure
IMP
PMID:12486173
Mice lacking D5 dopamine receptors have increased sympatheti... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12486173
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.
GO:0045777 positive regulation of blood pressure
IGI
PMID:9691085
Disruption of the dopamine D3 receptor gene produces renin-d... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9691085
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.
GO:0045777 positive regulation of blood pressure
IDA
PMID:12486173
Mice lacking D5 dopamine receptors have increased sympatheti... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12486173
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.
GO:0005737 cytoplasm
IDA
PMID:15499027
Angiotensin II impairs neurovascular coupling in neocortex t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15499027
Epub 2004 Oct 21. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
GO:0005886 plasma membrane
IDA
PMID:15499027
Angiotensin II impairs neurovascular coupling in neocortex t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15499027
Epub 2004 Oct 21. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
GO:0001568 blood vessel development
IGI
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
GO:0001822 kidney development
IMP
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and so... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
GO:0001822 kidney development
IGI
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
IGI
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
GO:0002001 renin secretion into blood stream
IMP
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and so... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
GO:0002018 renin-angiotensin regulation of aldosterone production
IMP
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and so... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
GO:0002019 regulation of renal output by angiotensin
IMP
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and so... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
GO:0042756 drinking behavior
IMP
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and so... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
GO:0001596 angiotensin type I receptor activity
IDA
PMID:12657564
A role for angiotensin II AT1 receptors in ureteric bud cell... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12657564
A role for angiotensin II AT1 receptors in ureteric bud cell branching.
GO:0002035 brain renin-angiotensin system
IMP
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in the brain.
GO:0042756 drinking behavior
IMP
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in the brain.
GO:0042756 drinking behavior
IGI
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in t... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in the brain.
GO:0005768 endosome
IDA
PMID:14718562
Phospholipase D2 localizes to the plasma membrane and regula... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14718562
Jan 12. Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.
GO:0005886 plasma membrane
IDA
PMID:14718562
Phospholipase D2 localizes to the plasma membrane and regula... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14718562
Jan 12. Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.
GO:0007186 G protein-coupled receptor signaling pathway
IC
PMID:12657564
A role for angiotensin II AT1 receptors in ureteric bud cell... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12657564
A role for angiotensin II AT1 receptors in ureteric bud cell branching.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10358057
Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.
PMID:10880053
Divergent functions of angiotensin II receptor isoforms in the brain.
PMID:12167595
Effects of AT(1A) receptor deletion on blood pressure and sodium excretion during altered dietary salt intake.
PMID:12486173
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.
PMID:12657564
A role for angiotensin II AT1 receptors in ureteric bud cell branching.
PMID:14718562
Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.
PMID:15499027
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
PMID:15757644
The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.
PMID:16585392
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
PMID:19023134
Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.
PMID:19404405
Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation.
PMID:19508861
The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms.
PMID:24206662
Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia.
PMID:26531127
Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.
PMID:9466969
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
PMID:9691085
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.

📄 View Raw YAML

 
id: P29754
gene_symbol: Agtr1a
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Agtr1a'
existing_annotations:
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001822
      label: kidney development
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038166
      label: angiotensin-activated signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007204
      label: positive regulation of cytosolic calcium ion concentration
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001596
      label: angiotensin type I receptor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003081
      label: regulation of systemic arterial blood pressure by renin-angiotensin
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004945
      label: angiotensin type II receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019229
      label: regulation of vasoconstriction
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10358057
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10358057
          supporting_text: Cloning and characterization of ATRAP, a novel 
            protein that interacts with the angiotensin II type 1 receptor.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15757644
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15757644
          supporting_text: The novel angiotensin II type 1 receptor 
            (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates 
            cardiomyocyte hypertrophy.
  - term:
      id: GO:0001596
      label: angiotensin type I receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001921
      label: positive regulation of receptor recycling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002018
      label: renin-angiotensin regulation of aldosterone production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006885
      label: regulation of pH
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007200
      label: phospholipase C-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009651
      label: response to salt stress
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014823
      label: response to activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016323
      label: basolateral plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031410
      label: cytoplasmic vesicle
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031748
      label: D1 dopamine receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031968
      label: organelle outer membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032930
      label: positive regulation of superoxide anion generation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038166
      label: angiotensin-activated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042416
      label: dopamine biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042756
      label: drinking behavior
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043627
      label: response to estrogen
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045766
      label: positive regulation of angiogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045777
      label: positive regulation of blood pressure
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051412
      label: response to corticosterone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0055037
      label: recycling endosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071549
      label: cellular response to dexamethasone stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090190
      label: positive regulation of branching involved in ureteric bud 
        morphogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905665
      label: positive regulation of calcium ion import across plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990776
      label: response to angiotensin
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042976
      label: activation of Janus kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001596
      label: angiotensin type I receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001596
      label: angiotensin type I receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001822
      label: kidney development
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001921
      label: positive regulation of receptor recycling
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002018
      label: renin-angiotensin regulation of aldosterone production
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002034
      label: maintenance of blood vessel diameter homeostasis by 
        renin-angiotensin
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004945
      label: angiotensin type II receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006885
      label: regulation of pH
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007200
      label: phospholipase C-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007200
      label: phospholipase C-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007204
      label: positive regulation of cytosolic calcium ion concentration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007266
      label: Rho protein signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010744
      label: positive regulation of macrophage derived foam cell differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016323
      label: basolateral plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019229
      label: regulation of vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019722
      label: calcium-mediated signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031410
      label: cytoplasmic vesicle
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031711
      label: bradykinin receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031748
      label: D1 dopamine receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031968
      label: organelle outer membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032930
      label: positive regulation of superoxide anion generation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038166
      label: angiotensin-activated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038166
      label: angiotensin-activated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042416
      label: dopamine biosynthetic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042756
      label: drinking behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043627
      label: response to estrogen
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045766
      label: positive regulation of angiogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045777
      label: positive regulation of blood pressure
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046718
      label: symbiont entry into host cell
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046982
      label: protein heterodimerization activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0055037
      label: recycling endosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060326
      label: cell chemotaxis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071549
      label: cellular response to dexamethasone stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0086097
      label: phospholipase C-activating angiotensin-activated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090190
      label: positive regulation of branching involved in ureteric bud 
        morphogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090205
      label: positive regulation of cholesterol metabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1903589
      label: positive regulation of blood vessel endothelial cell proliferation 
        involved in sprouting angiogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905665
      label: positive regulation of calcium ion import across plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:24206662
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24206662
          supporting_text: Mineralocorticoid receptor phosphorylation regulates 
            ligand binding and renal response to volume depletion and 
            hyperkalemia.
  - term:
      id: GO:0002034
      label: maintenance of blood vessel diameter homeostasis by 
        renin-angiotensin
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:26531127
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26531127
          supporting_text: Nov 3. Age-dependent blood pressure elevation is due 
            to increased vascular smooth muscle tone mediated by G-protein 
            signalling.
  - term:
      id: GO:0006954
      label: inflammatory response
    evidence_type: IGI
    original_reference_id: PMID:19404405
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19404405
          supporting_text: Angiotensin-(1-7) and the g protein-coupled receptor 
            MAS are key players in renal inflammation.
  - term:
      id: GO:0034391
      label: regulation of smooth muscle cell apoptotic process
    evidence_type: IGI
    original_reference_id: PMID:19508861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19508861
          supporting_text: Epub 2009 Jun 7. The heterogenous nuclear riboprotein
            S1-1 regulates AT1 receptor gene expression via transcriptional and 
            posttranscriptional mechanisms.
  - term:
      id: GO:0034392
      label: negative regulation of smooth muscle cell apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:19508861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19508861
          supporting_text: Epub 2009 Jun 7. The heterogenous nuclear riboprotein
            S1-1 regulates AT1 receptor gene expression via transcriptional and 
            posttranscriptional mechanisms.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IMP
    original_reference_id: PMID:19508861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19508861
          supporting_text: Epub 2009 Jun 7. The heterogenous nuclear riboprotein
            S1-1 regulates AT1 receptor gene expression via transcriptional and 
            posttranscriptional mechanisms.
  - term:
      id: GO:0002035
      label: brain renin-angiotensin system
    evidence_type: IMP
    original_reference_id: PMID:16585392
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16585392
          supporting_text: Role of p90 ribosomal S6 kinase-mediated 
            prorenin-converting enzyme in ischemic and diabetic myocardium.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IMP
    original_reference_id: PMID:16585392
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16585392
          supporting_text: Role of p90 ribosomal S6 kinase-mediated 
            prorenin-converting enzyme in ischemic and diabetic myocardium.
  - term:
      id: GO:0001819
      label: positive regulation of cytokine production
    evidence_type: IMP
    original_reference_id: PMID:19023134
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19023134
          supporting_text: 2008 Nov 20. Serotonin and angiotensin receptors in 
            cardiac fibroblasts coregulate adrenergic-dependent cardiac 
            hypertrophy.
  - term:
      id: GO:0045777
      label: positive regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:12486173
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12486173
          supporting_text: Mice lacking D5 dopamine receptors have increased 
            sympathetic tone and are hypertensive.
  - term:
      id: GO:0045777
      label: positive regulation of blood pressure
    evidence_type: IGI
    original_reference_id: PMID:9691085
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9691085
          supporting_text: Disruption of the dopamine D3 receptor gene produces 
            renin-dependent hypertension.
  - term:
      id: GO:0045777
      label: positive regulation of blood pressure
    evidence_type: IDA
    original_reference_id: PMID:12486173
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12486173
          supporting_text: Mice lacking D5 dopamine receptors have increased 
            sympathetic tone and are hypertensive.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:15499027
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15499027
          supporting_text: Epub 2004 Oct 21. Angiotensin II impairs 
            neurovascular coupling in neocortex through NADPH oxidase-derived 
            radicals.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:15499027
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15499027
          supporting_text: Epub 2004 Oct 21. Angiotensin II impairs 
            neurovascular coupling in neocortex through NADPH oxidase-derived 
            radicals.
  - term:
      id: GO:0001568
      label: blood vessel development
    evidence_type: IGI
    original_reference_id: PMID:9466969
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9466969
          supporting_text: Murine double nullizygotes of the angiotensin type 1A
            and 1B receptor genes duplicate severe abnormal phenotypes of 
            angiotensinogen nullizygotes.
  - term:
      id: GO:0001822
      label: kidney development
    evidence_type: IMP
    original_reference_id: PMID:12167595
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12167595
          supporting_text: Effects of AT(1A) receptor deletion on blood pressure
            and sodium excretion during altered dietary salt intake.
  - term:
      id: GO:0001822
      label: kidney development
    evidence_type: IGI
    original_reference_id: PMID:9466969
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9466969
          supporting_text: Murine double nullizygotes of the angiotensin type 1A
            and 1B receptor genes duplicate severe abnormal phenotypes of 
            angiotensinogen nullizygotes.
  - term:
      id: GO:0001991
      label: regulation of systemic arterial blood pressure by circulatory 
        renin-angiotensin
    evidence_type: IGI
    original_reference_id: PMID:9466969
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9466969
          supporting_text: Murine double nullizygotes of the angiotensin type 1A
            and 1B receptor genes duplicate severe abnormal phenotypes of 
            angiotensinogen nullizygotes.
  - term:
      id: GO:0002001
      label: renin secretion into blood stream
    evidence_type: IMP
    original_reference_id: PMID:12167595
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12167595
          supporting_text: Effects of AT(1A) receptor deletion on blood pressure
            and sodium excretion during altered dietary salt intake.
  - term:
      id: GO:0002018
      label: renin-angiotensin regulation of aldosterone production
    evidence_type: IMP
    original_reference_id: PMID:12167595
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12167595
          supporting_text: Effects of AT(1A) receptor deletion on blood pressure
            and sodium excretion during altered dietary salt intake.
  - term:
      id: GO:0002019
      label: regulation of renal output by angiotensin
    evidence_type: IMP
    original_reference_id: PMID:12167595
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12167595
          supporting_text: Effects of AT(1A) receptor deletion on blood pressure
            and sodium excretion during altered dietary salt intake.
  - term:
      id: GO:0042756
      label: drinking behavior
    evidence_type: IMP
    original_reference_id: PMID:12167595
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12167595
          supporting_text: Effects of AT(1A) receptor deletion on blood pressure
            and sodium excretion during altered dietary salt intake.
  - term:
      id: GO:0001596
      label: angiotensin type I receptor activity
    evidence_type: IDA
    original_reference_id: PMID:12657564
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12657564
          supporting_text: A role for angiotensin II AT1 receptors in ureteric 
            bud cell branching.
  - term:
      id: GO:0002035
      label: brain renin-angiotensin system
    evidence_type: IMP
    original_reference_id: PMID:10880053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10880053
          supporting_text: Divergent functions of angiotensin II receptor 
            isoforms in the brain.
  - term:
      id: GO:0042756
      label: drinking behavior
    evidence_type: IMP
    original_reference_id: PMID:10880053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10880053
          supporting_text: Divergent functions of angiotensin II receptor 
            isoforms in the brain.
  - term:
      id: GO:0042756
      label: drinking behavior
    evidence_type: IGI
    original_reference_id: PMID:10880053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10880053
          supporting_text: Divergent functions of angiotensin II receptor 
            isoforms in the brain.
  - term:
      id: GO:0005768
      label: endosome
    evidence_type: IDA
    original_reference_id: PMID:14718562
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14718562
          supporting_text: Jan 12. Phospholipase D2 localizes to the plasma 
            membrane and regulates angiotensin II receptor endocytosis.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:14718562
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14718562
          supporting_text: Jan 12. Phospholipase D2 localizes to the plasma 
            membrane and regulates angiotensin II receptor endocytosis.
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IC
    original_reference_id: PMID:12657564
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12657564
          supporting_text: A role for angiotensin II AT1 receptors in ureteric 
            bud cell branching.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10358057
    title: Cloning and characterization of ATRAP, a novel protein that interacts
      with the angiotensin II type 1 receptor.
    findings: []
  - id: PMID:10880053
    title: Divergent functions of angiotensin II receptor isoforms in the brain.
    findings: []
  - id: PMID:12167595
    title: Effects of AT(1A) receptor deletion on blood pressure and sodium 
      excretion during altered dietary salt intake.
    findings: []
  - id: PMID:12486173
    title: Mice lacking D5 dopamine receptors have increased sympathetic tone 
      and are hypertensive.
    findings: []
  - id: PMID:12657564
    title: A role for angiotensin II AT1 receptors in ureteric bud cell 
      branching.
    findings: []
  - id: PMID:14718562
    title: Phospholipase D2 localizes to the plasma membrane and regulates 
      angiotensin II receptor endocytosis.
    findings: []
  - id: PMID:15499027
    title: Angiotensin II impairs neurovascular coupling in neocortex through 
      NADPH oxidase-derived radicals.
    findings: []
  - id: PMID:15757644
    title: The novel angiotensin II type 1 receptor (AT1R)-associated protein 
      ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.
    findings: []
  - id: PMID:16585392
    title: Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme 
      in ischemic and diabetic myocardium.
    findings: []
  - id: PMID:19023134
    title: Serotonin and angiotensin receptors in cardiac fibroblasts coregulate
      adrenergic-dependent cardiac hypertrophy.
    findings: []
  - id: PMID:19404405
    title: Angiotensin-(1-7) and the g protein-coupled receptor MAS are key 
      players in renal inflammation.
    findings: []
  - id: PMID:19508861
    title: The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene
      expression via transcriptional and posttranscriptional mechanisms.
    findings: []
  - id: PMID:24206662
    title: Mineralocorticoid receptor phosphorylation regulates ligand binding 
      and renal response to volume depletion and hyperkalemia.
    findings: []
  - id: PMID:26531127
    title: Age-dependent blood pressure elevation is due to increased vascular 
      smooth muscle tone mediated by G-protein signalling.
    findings: []
  - id: PMID:9466969
    title: Murine double nullizygotes of the angiotensin type 1A and 1B receptor
      genes duplicate severe abnormal phenotypes of angiotensinogen 
      nullizygotes.
    findings: []
  - id: PMID:9691085
    title: Disruption of the dopamine D3 receptor gene produces renin-dependent 
      hypertension.
    findings: []