Akt1

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: negative regulation of apoptotic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: insulin receptor signaling pathway pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: positive regulation of blood vessel endothelial cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: ATP binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: mitochondrial intermembrane space pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Location inferred solely from the over-annotated GO:0036316 process row.

Reason: GO_REF:0000108 infers a location from a process annotation; the supporting entity here is GO:0036316 (SREBP-SCAP complex retention in endoplasmic reticulum), itself an over-annotation transferred from a human GO-CAM (see that row). In the source model AKT1 acts in the cytosol and it is PCK1, after AKT phosphorylation, that moves to the ER. This row therefore carries no independent evidence that Akt1 resides in the ER, and it should fall away with the process row.

Summary: plasma membrane localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: negative regulation of PERK-mediated unfolded protein response pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: osteoblast differentiation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of endothelial cell proliferation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cell migration involved in sprouting angiogenesis pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: complement receptor mediated signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: sphingosine-1-phosphate receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: calmodulin binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: phosphatidylinositol-3,4,5-trisphosphate binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: nucleoplasm pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: regulation of glycogen biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: epidermal growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: insulin receptor signaling pathway pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: negative regulation of autophagy pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of endothelial cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of gene expression pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of long-chain fatty acid import across plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of glucose metabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic membrane annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: Generic kinase binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: nitric-oxide synthase regulator activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of cell growth pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of protein ubiquitination pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: vesicle pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of fatty acid beta-oxidation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to insulin stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: Generic protein-containing complex annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: response to fluid shear stress pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: interleukin-18-mediated signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of protein import into nucleus pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic identical protein binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Generic protein homodimerization activity annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: negative regulation of apoptotic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: phosphatidylinositol-3,4-bisphosphate binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: positive regulation of blood vessel endothelial cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of nitric oxide biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of fat cell differentiation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of glycogen biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of proteolysis pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of transcription by RNA polymerase II pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of D-glucose import across plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of lipid biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: insulin-like growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of smooth muscle cell proliferation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: response to UV-A pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: protein localization to mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: response to growth factor pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to epidermal growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: 14-3-3 protein binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: maintenance of protein location in mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: potassium channel activator activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: regulation of tRNA methylation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to oxidised low-density lipoprotein particle stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: negative regulation of protein localization to lysosome pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cGAS/STING signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein localization to nucleus pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cilium assembly pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of leukocyte cell-cell adhesion pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein localization to plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of TORC1 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: TORC2 complex binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: positive regulation of protein localization to endoplasmic reticulum pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of anaphase-promoting complex-dependent catabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to nerve growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: negative regulation of lymphocyte migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein import into nucleus pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: plasma membrane localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: phosphorylation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: positive regulation of endodeoxyribonuclease activity pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: perinuclear theca pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of peptidyl-serine phosphorylation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: sperm principal piece pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: sperm end piece pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: sperm glycocalyx pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: osteoblast differentiation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of endothelial cell proliferation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cell migration involved in sprouting angiogenesis pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytoplasmic translation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: complement receptor mediated signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: sphingosine-1-phosphate receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: protein kinase C binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: calmodulin binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: ATP binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: ATP binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: phosphatidylinositol-3,4,5-trisphosphate binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: nucleoplasm pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: cilium pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: glycogen biosynthetic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: regulation of glycogen biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: gluconeogenesis pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: translation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: translational initiation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: ubiquitin-dependent protein catabolic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein import into nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: NLS-bearing protein import into nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: endoplasmic reticulum to Golgi vesicle-mediated transport pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Golgi to plasma membrane transport pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: DNA damage response pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: epidermal growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: insulin receptor signaling pathway pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: insulin receptor signaling pathway pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: cellular response to starvation pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: negative regulation of autophagy pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of endothelial cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of gene expression pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of long-chain fatty acid import across plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of glucose metabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of mitochondrial membrane potential pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: response to muscle activity pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: microtubule cytoskeleton pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Generic membrane annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: cell migration pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Generic enzyme binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Generic kinase binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Generic protein kinase binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: spinal cord development pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: nitric-oxide synthase regulator activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein serine/threonine kinase inhibitor activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of cell growth pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of cell growth pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: dendrite pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: anaphase-promoting complex-dependent catabolic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of protein ubiquitination pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: response to nutrient levels pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to nutrient levels pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: vesicle pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of fatty acid beta-oxidation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: GTPase activating protein binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to insulin stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to insulin stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: negative regulation of superoxide anion generation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein-containing complex annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: negative regulation of toll-like receptor signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of toll-like receptor signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: toll-like receptor 4 signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to amino acid starvation pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: response to fluid shear stress pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to heat pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: protein K29-linked ubiquitination pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: interleukin-18-mediated signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: ciliary basal body pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to platelet-derived growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: Orthology transfer of a GO-CAM-derived 'acts upstream of' row; AKT1 is two steps upstream of, and opposes, INSIG-mediated ER retention.

Reason: This ISO row is transferred from human AKT1 (P31749), whose source is the human GO-CAM gomodel:6205c24300000880 built from a single study of human hepatocellular carcinoma cells (PMID:32322062). In that model AKT1 kinase activity directly positively regulates PCK1, whose GTP-dependent kinase activity directly negatively regulates the INSIG activities that are part of GO:0036316. The row matches what a GO-CAM-to-GAF export yields for that two-step causal chain (an acts_upstream_of_or_within row for the process of the downstream activity). AKT1 is not part of the retention machinery (INSIG1/2 with sterol-bound SCAP), and the reported effect is the opposite of retention: PCK1 phosphorylation of INSIG lowers sterol binding and releases SCAP-SREBP to the Golgi. There is no mouse experiment behind the row, and the source annotation is absent from current human AKT1 GOA. AKT1's contribution to lipogenic SREBP activation is better captured by the experimentally supported human AKT1 terms (GO:0004674 kinase activity on PCK1 and GO:0046889 positive regulation of lipid biosynthetic process) than by a retention-process term.

Summary: tRNA stabilization pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: calcium import into the mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: PERK-mediated unfolded protein response pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: TORC1 signaling pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Generic identical protein binding annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Generic protein homodimerization activity annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Golgi to plasma membrane protein transport pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of apoptotic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of apoptotic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: proteasome-mediated ubiquitin-dependent protein catabolic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: phosphatidylinositol-3,4-bisphosphate binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: positive regulation of blood vessel endothelial cell migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of nitric oxide biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of cholesterol biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of fat cell differentiation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of cilium assembly pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of glycogen biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of proteolysis pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of vasoconstriction pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of transcription by RNA polymerase II pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of translational initiation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of translational initiation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of D-glucose import across plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of JNK cascade pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of lipid biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: insulin-like growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of smooth muscle cell proliferation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein metabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: protein maturation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein phosphatase 2A binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: regulation of vesicle-mediated transport pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: protein localization to cilium pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: response to UV-A pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: response to growth factor pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: protein localization to endoplasmic reticulum pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein K11-linked ubiquitination pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to mechanical stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to calcium ion pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to epidermal growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to epidermal growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to hypoxia pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular hyperosmotic salinity response pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: 14-3-3 protein binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: tricarboxylic acid metabolic process pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: maintenance of protein location in mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to sorbitol pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: protein K6-linked ubiquitination pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: potassium channel activator activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: tRNA (guanine-N7)-methylation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: regulation of tRNA methylation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of calcium import into the mitochondrion pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: protein serine/threonine kinase binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to oxidised low-density lipoprotein particle stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cGAS/STING signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of protein localization to lysosome pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cGAS/STING signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of G1/S transition of mitotic cell cycle pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein localization to nucleus pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cilium assembly pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of leukocyte cell-cell adhesion pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein localization to plasma membrane pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: regulation of aerobic respiration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of TORC1 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of TORC1 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: TORC2 complex binding supports AKT1 activation or recruitment

Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.

Summary: positive regulation of protein localization to endoplasmic reticulum pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of anaphase-promoting complex-dependent catabolic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to nerve growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to nerve growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: negative regulation of lymphocyte migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: smoothened signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: lateral motor column neuron differentiation pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: protein stabilization pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: gene expression pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: cellular response to growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: positive regulation of TORC2 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of TORC2 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: negative regulation of PERK-mediated unfolded protein response pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein-containing complex annotation

Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: mitochondrial intermembrane space pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: glutamatergic synapse pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: glutamatergic synapse pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: regulation of postsynapse organization pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: regulation of postsynapse organization pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of cilium assembly pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: negative regulation of protein localization to lysosome pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of TORC1 signaling pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: mammalian oogenesis stage pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: insulin-like growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: insulin-like growth factor receptor signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: insulin receptor signaling pathway pathway context

Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.

Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: plasma membrane localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: Direct AKT1 phosphorylation activity

Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.

Summary: inflammatory response pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: response to heat pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: behavioral response to pain pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of gene expression pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: potassium channel activator activity pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytosol localization lacks direct support in the cached PMID:28930673 record

Reason: AKT1 cytosolic localization is plausible, but the cached PexRAP/PRDM16 source does not directly support this evidence-specific annotation.

Summary: positive regulation of lipid biosynthetic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: gene expression pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: negative regulation of intrinsic apoptotic signaling pathway pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: calmodulin binding pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: regulation of protein localization pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of protein localization to cell surface pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: positive regulation of gene expression pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: cellular response to tumor necrosis factor pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: regulation of apoptotic process pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: plasma membrane localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: positive regulation of organ growth pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: nucleus pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: positive regulation of fibroblast migration pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to vascular endothelial growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: plasma membrane localization lacks direct support in the cached PMID:25217619 record

Reason: AKT1 plasma membrane recruitment is plausible in PI3K signaling, but the cached PI3K p85beta/invadopodia source does not directly support this evidence-specific localization annotation.

Summary: cellular response to decreased oxygen levels pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: response to growth hormone pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: response to insulin-like growth factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: lipopolysaccharide-mediated signaling pathway pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to prostaglandin E stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: cytosol localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: plasma membrane localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: regulation of neuron projection development pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.

Summary: response to oxidative stress pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: regulation of myelination pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: plasma membrane localization lacks direct support in the cached PMID:22750946 record

Reason: The cached N-BAR/plasma-membrane-curvature source does not directly support an AKT1-specific plasma membrane localization annotation.

Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity

Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.

Summary: cytoplasm localization

Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Summary: ciliary basal body pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cell-cell junction pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: cellular response to peptide pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: cellular response to granulocyte macrophage colony-stimulating factor stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: positive regulation of endothelial cell proliferation pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: Generic protein binding

Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.

Summary: mitochondrion pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: execution phase of apoptosis pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: positive regulation of sodium ion transport pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: cellular response to insulin stimulus pathway context

Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.

Summary: regulation of protein localization pathway context

Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.

Summary: peripheral nervous system myelin maintenance pathway context

Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.

Summary: Core AKT1 serine/threonine kinase activity

Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates.