Akt1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005737 cytoplasm	IBA GO_REF:0000033	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0004674 protein serine/threonine kinase activity	IBA GO_REF:0000033	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes file:mouse/Akt1/Akt1-deep-research-falcon.md Falcon synthesis supports Akt1 as a PH-domain AGC serine/threonine kinase activated downstream of PI3K by membrane recruitment and phosphorylation.
GO:0035556 intracellular signal transduction	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: intracellular signal transduction pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0043066 negative regulation of apoptotic process	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0008286 insulin receptor signaling pathway	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0043536 positive regulation of blood vessel endothelial cell migration	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of blood vessel endothelial cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0004672 protein kinase activity	IEA GO_REF:0000120	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0004674 protein serine/threonine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0005524 ATP binding	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: ATP binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0005634 nucleus	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005737 cytoplasm	IEA GO_REF:0000120	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005758 mitochondrial intermembrane space	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: mitochondrial intermembrane space pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005783 endoplasmic reticulum	IEA GO_REF:0000108	KEEP AS NON CORE	Summary: endoplasmic reticulum pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005886 plasma membrane	IEA GO_REF:0000120	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:1903898 negative regulation of PERK-mediated unfolded protein response	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: negative regulation of PERK-mediated unfolded protein response pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:12791994 TRB3: a tribbles homolog that inhibits Akt/PKB activation by...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:16051150 An Akt/beta-arrestin 2/PP2A signaling complex mediates dopam...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:18566586 The mammalian target of rapamycin complex 2 controls folding...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:19122674 Deficiency of a beta-arrestin-2 signal complex contributes t...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:19698782 Evidence for the involvement of FAM110C protein in cell spre...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:21339740 Selective activation of Akt1 by mammalian target of rapamyci...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:22309289 Akt augments the oncogenic potential of the HBx protein of h...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:24955524 Akt1 mediates the posterior Hoxc gene expression through epi...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0001649 osteoblast differentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: osteoblast differentiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0001938 positive regulation of endothelial cell proliferation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of endothelial cell proliferation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0002042 cell migration involved in sprouting angiogenesis	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cell migration involved in sprouting angiogenesis pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0002430 complement receptor mediated signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: complement receptor mediated signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0003376 sphingosine-1-phosphate receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: sphingosine-1-phosphate receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004712 protein serine/threonine/tyrosine kinase activity	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0005516 calmodulin binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: calmodulin binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phosphatidylinositol-3,4,5-trisphosphate binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0005654 nucleoplasm	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: nucleoplasm pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005829 cytosol	IEA GO_REF:0000107	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005979 regulation of glycogen biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of glycogen biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0007173 epidermal growth factor receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: epidermal growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0008286 insulin receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0010507 negative regulation of autophagy	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of autophagy pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010595 positive regulation of endothelial cell migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of endothelial cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010628 positive regulation of gene expression	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of gene expression pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of long-chain fatty acid import across plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010907 positive regulation of glucose metabolic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of glucose metabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0016020 membrane	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic membrane annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0016301 kinase activity	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0019900 kinase binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic kinase binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0030235 nitric-oxide synthase regulator activity	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: nitric-oxide synthase regulator activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0030307 positive regulation of cell growth	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of cell growth pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030334 regulation of cell migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030335 positive regulation of cell migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0031397 negative regulation of protein ubiquitination	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of protein ubiquitination pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0031982 vesicle	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: vesicle pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0031999 negative regulation of fatty acid beta-oxidation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of fatty acid beta-oxidation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032869 cellular response to insulin stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032991 protein-containing complex	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic protein-containing complex annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0034405 response to fluid shear stress	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to fluid shear stress pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0035655 interleukin-18-mediated signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: interleukin-18-mediated signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0042307 positive regulation of protein import into nucleus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein import into nucleus pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0042802 identical protein binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic identical protein binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0042803 protein homodimerization activity	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic protein homodimerization activity annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0043066 negative regulation of apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phosphatidylinositol-3,4-bisphosphate binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0043536 positive regulation of blood vessel endothelial cell migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of blood vessel endothelial cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045429 positive regulation of nitric oxide biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of nitric oxide biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045600 positive regulation of fat cell differentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of fat cell differentiation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045725 positive regulation of glycogen biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of glycogen biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045861 negative regulation of proteolysis	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of proteolysis pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045944 positive regulation of transcription by RNA polymerase II	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of transcription by RNA polymerase II pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046326 positive regulation of D-glucose import across plasma membrane	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of D-glucose import across plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046889 positive regulation of lipid biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of lipid biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0048009 insulin-like growth factor receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: insulin-like growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0048661 positive regulation of smooth muscle cell proliferation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of smooth muscle cell proliferation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0070141 response to UV-A	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to UV-A pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0070585 protein localization to mitochondrion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: protein localization to mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0070848 response to growth factor	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to growth factor pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071364 cellular response to epidermal growth factor stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to epidermal growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071889 14-3-3 protein binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: 14-3-3 protein binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0072656 maintenance of protein location in mitochondrion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: maintenance of protein location in mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0099104 potassium channel activator activity	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: potassium channel activator activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0106310 protein serine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0110002 regulation of tRNA methylation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of tRNA methylation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to oxidised low-density lipoprotein particle stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0150033 negative regulation of protein localization to lysosome	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of protein localization to lysosome pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0160049 negative regulation of cGAS/STING signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of cGAS/STING signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1900182 positive regulation of protein localization to nucleus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein localization to nucleus pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1902018 negative regulation of cilium assembly	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of cilium assembly pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903038 negative regulation of leukocyte cell-cell adhesion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of leukocyte cell-cell adhesion pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903078 positive regulation of protein localization to plasma membrane	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein localization to plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904263 positive regulation of TORC1 signaling	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of TORC1 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904841 TORC2 complex binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: TORC2 complex binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:1905552 positive regulation of protein localization to endoplasmic reticulum	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein localization to endoplasmic reticulum pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of anaphase-promoting complex-dependent catabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1990090 cellular response to nerve growth factor stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to nerve growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:2000402 negative regulation of lymphocyte migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of lymphocyte migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0042307 positive regulation of protein import into nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of protein import into nucleus pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005886 plasma membrane	ISO GO_REF:0000119	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0106310 protein serine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0004674 protein serine/threonine kinase activity	EXP PMID:10454575 Insulin-induced phosphorylation and activation of cyclic nuc...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-MMU-1445150	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-MMU-9857656	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-MMU-9857664	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0005634 nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005829 cytosol	ISO GO_REF:0000119	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0006468 protein phosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0006468 protein phosphorylation	ISO GO_REF:0000119	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0016310 phosphorylation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phosphorylation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0018105 peptidyl-serine phosphorylation	ISO GO_REF:0000119	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0018107 peptidyl-threonine phosphorylation	ISO GO_REF:0000119	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0032079 positive regulation of endodeoxyribonuclease activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of endodeoxyribonuclease activity pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0033011 perinuclear theca	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: perinuclear theca pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0033138 positive regulation of peptidyl-serine phosphorylation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of peptidyl-serine phosphorylation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046777 protein autophosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0097228 sperm principal piece	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: sperm principal piece pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0097229 sperm end piece	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: sperm end piece pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0120238 sperm glycocalyx	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: sperm glycocalyx pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0001649 osteoblast differentiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: osteoblast differentiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0001938 positive regulation of endothelial cell proliferation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of endothelial cell proliferation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0002042 cell migration involved in sprouting angiogenesis	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cell migration involved in sprouting angiogenesis pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0002181 cytoplasmic translation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cytoplasmic translation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0002430 complement receptor mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: complement receptor mediated signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0003376 sphingosine-1-phosphate receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: sphingosine-1-phosphate receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004672 protein kinase activity	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0004672 protein kinase activity	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0004674 protein serine/threonine kinase activity	ISO GO_REF:0000096	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004674 protein serine/threonine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004712 protein serine/threonine/tyrosine kinase activity	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0005080 protein kinase C binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: protein kinase C binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005516 calmodulin binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: calmodulin binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005524 ATP binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: ATP binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0005524 ATP binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ATP binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phosphatidylinositol-3,4,5-trisphosphate binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0005634 nucleus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005654 nucleoplasm	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: nucleoplasm pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005737 cytoplasm	ISO GO_REF:0000119	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005739 mitochondrion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005829 cytosol	ISO GO_REF:0000096	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005929 cilium	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cilium pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005978 glycogen biosynthetic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: glycogen biosynthetic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005979 regulation of glycogen biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: regulation of glycogen biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0006094 gluconeogenesis	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: gluconeogenesis pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006412 translation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: translation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006413 translational initiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: translational initiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006511 ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ubiquitin-dependent protein catabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006606 protein import into nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein import into nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006607 NLS-bearing protein import into nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: NLS-bearing protein import into nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: endoplasmic reticulum to Golgi vesicle-mediated transport pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006893 Golgi to plasma membrane transport	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Golgi to plasma membrane transport pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006974 DNA damage response	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: DNA damage response pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0007173 epidermal growth factor receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: epidermal growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0008286 insulin receptor signaling pathway	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0008286 insulin receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0009267 cellular response to starvation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to starvation pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0010507 negative regulation of autophagy	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of autophagy pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010595 positive regulation of endothelial cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of endothelial cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010628 positive regulation of gene expression	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of gene expression pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of long-chain fatty acid import across plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010907 positive regulation of glucose metabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of glucose metabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010918 positive regulation of mitochondrial membrane potential	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of mitochondrial membrane potential pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0014850 response to muscle activity	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: response to muscle activity pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0015630 microtubule cytoskeleton	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: microtubule cytoskeleton pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0016020 membrane	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic membrane annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0016477 cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cell migration pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0019899 enzyme binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: Generic enzyme binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0019900 kinase binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic kinase binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0019901 protein kinase binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: Generic protein kinase binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0021510 spinal cord development	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: spinal cord development pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0030235 nitric-oxide synthase regulator activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: nitric-oxide synthase regulator activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0030291 protein serine/threonine kinase inhibitor activity	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: protein serine/threonine kinase inhibitor activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0030307 positive regulation of cell growth	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of cell growth pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030307 positive regulation of cell growth	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of cell growth pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030334 regulation of cell migration	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030334 regulation of cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030335 positive regulation of cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030336 negative regulation of cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030425 dendrite	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendrite pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0031145 anaphase-promoting complex-dependent catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: anaphase-promoting complex-dependent catabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0031397 negative regulation of protein ubiquitination	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of protein ubiquitination pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0031667 response to nutrient levels	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: response to nutrient levels pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0031669 cellular response to nutrient levels	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to nutrient levels pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0031982 vesicle	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: vesicle pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0031999 negative regulation of fatty acid beta-oxidation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of fatty acid beta-oxidation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032794 GTPase activating protein binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: GTPase activating protein binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0032869 cellular response to insulin stimulus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032869 cellular response to insulin stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032929 negative regulation of superoxide anion generation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of superoxide anion generation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032991 protein-containing complex	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic protein-containing complex annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0034122 negative regulation of toll-like receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of toll-like receptor signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0034123 positive regulation of toll-like receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of toll-like receptor signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0034142 toll-like receptor 4 signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: toll-like receptor 4 signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0034198 cellular response to amino acid starvation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to amino acid starvation pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0034405 response to fluid shear stress	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: response to fluid shear stress pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0034605 cellular response to heat	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to heat pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0035519 protein K29-linked ubiquitination	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein K29-linked ubiquitination pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0035655 interleukin-18-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-18-mediated signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0036064 ciliary basal body	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ciliary basal body pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0036120 cellular response to platelet-derived growth factor stimulus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to platelet-derived growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: SREBP-SCAP complex retention in endoplasmic reticulum pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0036416 tRNA stabilization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: tRNA stabilization pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0036444 calcium import into the mitochondrion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: calcium import into the mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0036499 PERK-mediated unfolded protein response	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: PERK-mediated unfolded protein response pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0038202 TORC1 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TORC1 signaling pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0042802 identical protein binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic identical protein binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0042803 protein homodimerization activity	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic protein homodimerization activity annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0043001 Golgi to plasma membrane protein transport	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Golgi to plasma membrane protein transport pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0043065 positive regulation of apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0043066 negative regulation of apoptotic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: proteasome-mediated ubiquitin-dependent protein catabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phosphatidylinositol-3,4-bisphosphate binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0043536 positive regulation of blood vessel endothelial cell migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of blood vessel endothelial cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045429 positive regulation of nitric oxide biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of nitric oxide biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045542 positive regulation of cholesterol biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of cholesterol biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045600 positive regulation of fat cell differentiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of fat cell differentiation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045724 positive regulation of cilium assembly	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of cilium assembly pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045725 positive regulation of glycogen biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of glycogen biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045861 negative regulation of proteolysis	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of proteolysis pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045907 positive regulation of vasoconstriction	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of vasoconstriction pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045944 positive regulation of transcription by RNA polymerase II	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of transcription by RNA polymerase II pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045947 negative regulation of translational initiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of translational initiation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0045948 positive regulation of translational initiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of translational initiation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046326 positive regulation of D-glucose import across plasma membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of D-glucose import across plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046329 negative regulation of JNK cascade	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of JNK cascade pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0046889 positive regulation of lipid biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of lipid biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0048009 insulin-like growth factor receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: insulin-like growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0048661 positive regulation of smooth muscle cell proliferation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of smooth muscle cell proliferation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0051247 positive regulation of protein metabolic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of protein metabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0051604 protein maturation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein maturation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0051721 protein phosphatase 2A binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: protein phosphatase 2A binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0060627 regulation of vesicle-mediated transport	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: regulation of vesicle-mediated transport pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0061512 protein localization to cilium	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein localization to cilium pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0070141 response to UV-A	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: response to UV-A pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0070848 response to growth factor	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: response to growth factor pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0070972 protein localization to endoplasmic reticulum	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein localization to endoplasmic reticulum pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0070979 protein K11-linked ubiquitination	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein K11-linked ubiquitination pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0071260 cellular response to mechanical stimulus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to mechanical stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071277 cellular response to calcium ion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to calcium ion pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071364 cellular response to epidermal growth factor stimulus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to epidermal growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071364 cellular response to epidermal growth factor stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to epidermal growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071456 cellular response to hypoxia	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to hypoxia pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071475 cellular hyperosmotic salinity response	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular hyperosmotic salinity response pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0071889 14-3-3 protein binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: 14-3-3 protein binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0072350 tricarboxylic acid metabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: tricarboxylic acid metabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0072656 maintenance of protein location in mitochondrion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: maintenance of protein location in mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0072709 cellular response to sorbitol	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to sorbitol pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0085020 protein K6-linked ubiquitination	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein K6-linked ubiquitination pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0099104 potassium channel activator activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: potassium channel activator activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0106004 tRNA (guanine-N7)-methylation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: tRNA (guanine-N7)-methylation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0110002 regulation of tRNA methylation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: regulation of tRNA methylation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0110099 negative regulation of calcium import into the mitochondrion	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of calcium import into the mitochondrion pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0120283 protein serine/threonine kinase binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: protein serine/threonine kinase binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to oxidised low-density lipoprotein particle stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0140896 cGAS/STING signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cGAS/STING signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0150033 negative regulation of protein localization to lysosome	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of protein localization to lysosome pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0160049 negative regulation of cGAS/STING signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of cGAS/STING signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of G1/S transition of mitotic cell cycle pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1900182 positive regulation of protein localization to nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of protein localization to nucleus pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1902018 negative regulation of cilium assembly	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of cilium assembly pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903038 negative regulation of leukocyte cell-cell adhesion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of leukocyte cell-cell adhesion pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903078 positive regulation of protein localization to plasma membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of protein localization to plasma membrane pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1903715 regulation of aerobic respiration	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: regulation of aerobic respiration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904262 negative regulation of TORC1 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of TORC1 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904263 positive regulation of TORC1 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of TORC1 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904841 TORC2 complex binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: TORC2 complex binding supports AKT1 activation or recruitment Reason: This molecular interaction is mechanistically plausible for AKT1 regulation but is accessory to the core serine/threonine kinase activity.
GO:1905552 positive regulation of protein localization to endoplasmic reticulum	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of protein localization to endoplasmic reticulum pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of anaphase-promoting complex-dependent catabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1990090 cellular response to nerve growth factor stimulus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to nerve growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:1990090 cellular response to nerve growth factor stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to nerve growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:2000402 negative regulation of lymphocyte migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of lymphocyte migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0007224 smoothened signaling pathway	IMP PMID:31305241 Critical roles of ARHGAP36 as a signal transduction mediator...	KEEP AS NON CORE	Summary: smoothened signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0021525 lateral motor column neuron differentiation	IMP PMID:31305241 Critical roles of ARHGAP36 as a signal transduction mediator...	KEEP AS NON CORE	Summary: lateral motor column neuron differentiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0050821 protein stabilization	IMP PMID:31305241 Critical roles of ARHGAP36 as a signal transduction mediator...	KEEP AS NON CORE	Summary: protein stabilization pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0010467 gene expression	IMP PMID:12851395 Akt signaling regulates side population cell phenotype via B...	KEEP AS NON CORE	Summary: gene expression pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004674 protein serine/threonine kinase activity	IMP PMID:23684622 Dynamic adipocyte phosphoproteome reveals that Akt directly ...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0004674 protein serine/threonine kinase activity	IMP PMID:26235620 A Positive Feedback Loop between Akt and mTORC2 via SIN1 Pho...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0071363 cellular response to growth factor stimulus	IMP PMID:23684622 Dynamic adipocyte phosphoproteome reveals that Akt directly ...	KEEP AS NON CORE	Summary: cellular response to growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0071363 cellular response to growth factor stimulus	IMP PMID:26235620 A Positive Feedback Loop between Akt and mTORC2 via SIN1 Pho...	KEEP AS NON CORE	Summary: cellular response to growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:1904515 positive regulation of TORC2 signaling	IMP PMID:23684622 Dynamic adipocyte phosphoproteome reveals that Akt directly ...	KEEP AS NON CORE	Summary: positive regulation of TORC2 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904515 positive regulation of TORC2 signaling	IMP PMID:26235620 A Positive Feedback Loop between Akt and mTORC2 via SIN1 Pho...	KEEP AS NON CORE	Summary: positive regulation of TORC2 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:21954288 Akt determines cell fate through inhibition of the PERK-eIF2...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:1903898 negative regulation of PERK-mediated unfolded protein response	IDA PMID:21954288 Akt determines cell fate through inhibition of the PERK-eIF2...	KEEP AS NON CORE	Summary: negative regulation of PERK-mediated unfolded protein response pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032991 protein-containing complex	ISO PMID:23223530 Protein kinase N1, a cell inhibitor of Akt kinase, has a cen...	MARK AS OVER ANNOTATED	Summary: Generic protein-containing complex annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:30504268 Akt-mediated phosphorylation of MICU1 regulates mitochondria...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0005758 mitochondrial intermembrane space	IDA PMID:30504268 Akt-mediated phosphorylation of MICU1 regulates mitochondria...	KEEP AS NON CORE	Summary: mitochondrial intermembrane space pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0098978 glutamatergic synapse	IDA PMID:26844834 Bidirectional Synaptic Structural Plasticity after Chronic C...	KEEP AS NON CORE	Summary: glutamatergic synapse pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0098978 glutamatergic synapse	IMP PMID:26844834 Bidirectional Synaptic Structural Plasticity after Chronic C...	KEEP AS NON CORE	Summary: glutamatergic synapse pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0099175 regulation of postsynapse organization	IDA PMID:26844834 Bidirectional Synaptic Structural Plasticity after Chronic C...	KEEP AS NON CORE	Summary: regulation of postsynapse organization pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0099175 regulation of postsynapse organization	IMP PMID:26844834 Bidirectional Synaptic Structural Plasticity after Chronic C...	KEEP AS NON CORE	Summary: regulation of postsynapse organization pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1902018 negative regulation of cilium assembly	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: negative regulation of cilium assembly pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0150033 negative regulation of protein localization to lysosome	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: negative regulation of protein localization to lysosome pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:1904263 positive regulation of TORC1 signaling	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of TORC1 signaling pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:34635817 Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertil...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0022605 mammalian oogenesis stage	IMP PMID:34635817 Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertil...	KEEP AS NON CORE	Summary: mammalian oogenesis stage pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0048009 insulin-like growth factor receptor signaling pathway	IDA PMID:11784871 Molecular balance between the regulatory and catalytic subun...	KEEP AS NON CORE	Summary: insulin-like growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0106310 protein serine kinase activity	IDA PMID:11784871 Molecular balance between the regulatory and catalytic subun...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0048009 insulin-like growth factor receptor signaling pathway	IGI PMID:32439763 Vessel-derived angiocrine IGF1 promotes Meckel's cartilage p...	KEEP AS NON CORE	Summary: insulin-like growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0016301 kinase activity	IDA PMID:23886629 The Akt substrate Girdin is a regulator of insulin signaling...	MARK AS OVER ANNOTATED	Summary: kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0008286 insulin receptor signaling pathway	IDA PMID:20889126 Insulin signaling to the glomerular podocyte is critical for...	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0004672 protein kinase activity	IDA PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0005886 plasma membrane	IDA PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0006468 protein phosphorylation	IDA PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0006954 inflammatory response	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: inflammatory response pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0009408 response to heat	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: response to heat pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0048266 behavioral response to pain	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: behavioral response to pain pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0010629 negative regulation of gene expression	IDA PMID:19933931 Reciprocal regulation of microRNA-1 and insulin-like growth ...	KEEP AS NON CORE	Summary: negative regulation of gene expression pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0099104 potassium channel activator activity	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: potassium channel activator activity pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005829 cytosol	IDA PMID:28930673 PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression.	UNDECIDED	Summary: cytosol localization lacks direct support in the cached PMID:28930673 record Reason: AKT1 cytosolic localization is plausible, but the cached PexRAP/PRDM16 source does not directly support this evidence-specific annotation.
GO:0046889 positive regulation of lipid biosynthetic process	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of lipid biosynthetic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010467 gene expression	IMP PMID:31272455 Matrix metalloproteinase activity in the lung is increased i...	KEEP AS NON CORE	Summary: gene expression pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway	IMP PMID:19911006 AATF mediates an antiapoptotic effect of the unfolded protei...	KEEP AS NON CORE	Summary: negative regulation of intrinsic apoptotic signaling pathway pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005516 calmodulin binding	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: calmodulin binding pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005515 protein binding	IPI PMID:19028694 Identification and characterization of a novel gene, dapr, i...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0032880 regulation of protein localization	IMP PMID:9415393 Physiological role of Akt in insulin-stimulated translocatio...	KEEP AS NON CORE	Summary: regulation of protein localization pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:2000010 positive regulation of protein localization to cell surface	IMP PMID:9415393 Physiological role of Akt in insulin-stimulated translocatio...	KEEP AS NON CORE	Summary: positive regulation of protein localization to cell surface pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010628 positive regulation of gene expression	IMP PMID:18292230 Akt and CHIP coregulate tau degradation through coordinated ...	KEEP AS NON CORE	Summary: positive regulation of gene expression pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:23300339 BSTA promotes mTORC2-mediated phosphorylation of Akt1 to sup...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0071356 cellular response to tumor necrosis factor	IDA PMID:24349514 MicroRNA-494, upregulated by tumor necrosis factor-α, desens...	KEEP AS NON CORE	Summary: cellular response to tumor necrosis factor pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0004674 protein serine/threonine kinase activity	IMP PMID:10983986 The protooncogene TCL1 is an Akt kinase coactivator.	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0042981 regulation of apoptotic process	IDA PMID:18977203 Akt activation prevents Apop-1-induced death of cells.	KEEP AS NON CORE	Summary: regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005886 plasma membrane	ISO PMID:17202487 Nonredundant role of Akt2 for neuroprotection of rod photore...	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0046622 positive regulation of organ growth	IMP PMID:15713641 Role for Akt3/protein kinase Bgamma in attainment of normal ...	KEEP AS NON CORE	Summary: positive regulation of organ growth pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005829 cytosol	TAS Reactome:R-MMU-9863573	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005829 cytosol	TAS Reactome:R-MMU-9906595	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005634 nucleus	IDA PMID:23786676 Id4 deficiency attenuates prostate development and promotes ...	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005737 cytoplasm	IDA PMID:23786676 Id4 deficiency attenuates prostate development and promotes ...	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain. Supporting Evidence: PMID:23786676 Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.
GO:0005515 protein binding	IPI PMID:16792529 A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambd...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005634 nucleus	IDA PMID:18388859 Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes a...	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005737 cytoplasm	IDA PMID:18388859 Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes a...	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0010763 positive regulation of fibroblast migration	IMP PMID:23871832 The small GTPase N-Ras regulates extracellular matrix synthe...	KEEP AS NON CORE	Summary: positive regulation of fibroblast migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0035924 cellular response to vascular endothelial growth factor stimulus	IDA PMID:25139353 Phosphoinositide 3-kinase β mediates microvascular endotheli...	KEEP AS NON CORE	Summary: cellular response to vascular endothelial growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0005886 plasma membrane	IDA PMID:25217619 Phosphoinositide 3-kinase p85beta regulates invadopodium for...	UNDECIDED	Summary: plasma membrane localization lacks direct support in the cached PMID:25217619 record Reason: AKT1 plasma membrane recruitment is plausible in PI3K signaling, but the cached PI3K p85beta/invadopodia source does not directly support this evidence-specific localization annotation.
GO:0036294 cellular response to decreased oxygen levels	IDA PMID:24875179 PTEN degradation after ischemic stroke: a double-edged sword...	KEEP AS NON CORE	Summary: cellular response to decreased oxygen levels pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0060416 response to growth hormone	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: response to growth hormone pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:1990418 response to insulin-like growth factor stimulus	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: response to insulin-like growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0031663 lipopolysaccharide-mediated signaling pathway	IDA PMID:24740015 Myeloid-specific Rictor deletion induces M1 macrophage polar...	KEEP AS NON CORE	Summary: lipopolysaccharide-mediated signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0071380 cellular response to prostaglandin E stimulus	IDA PMID:23479225 Selective impairment of P2Y signaling by prostaglandin E2 in...	KEEP AS NON CORE	Summary: cellular response to prostaglandin E stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0005829 cytosol	TAS Reactome:R-MMU-162352	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005829 cytosol	TAS Reactome:R-MMU-9857656	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005829 cytosol	TAS Reactome:R-MMU-9857664	ACCEPT	Summary: cytosol localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0005886 plasma membrane	TAS Reactome:R-MMU-1445150	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0010975 regulation of neuron projection development	IDA PMID:21976490 Leukocyte common antigen-related phosphatase is a functional...	KEEP AS NON CORE	Summary: regulation of neuron projection development pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:23223530 Protein kinase N1, a cell inhibitor of Akt kinase, has a cen...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:18160256 A novel Akt/PKB-interacting protein promotes cell adhesion a...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:24156551 KCTD20, a relative of BTBD10, is a positive regulator of Akt...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:23495099 Oct4 interaction with Hmgb2 regulates Akt signaling and plur...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0006979 response to oxidative stress	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: response to oxidative stress pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0031641 regulation of myelination	IMP PMID:24101522 MicroRNA-23a promotes myelination in the central nervous sys...	KEEP AS NON CORE	Summary: regulation of myelination pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005886 plasma membrane	IDA PMID:22750946 External push and internal pull forces recruit curvature-sen...	UNDECIDED	Summary: plasma membrane localization lacks direct support in the cached PMID:22750946 record Reason: The cached N-BAR/plasma-membrane-curvature source does not directly support an AKT1-specific plasma membrane localization annotation.
GO:0004712 protein serine/threonine/tyrosine kinase activity	ISO PMID:22797923 ZNRF2 is released from membranes by growth factors and, toge...	MARK AS OVER ANNOTATED	Summary: protein serine/threonine/tyrosine kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0005737 cytoplasm	IDA PMID:19596798 Growth arrest induces primary-cilium formation and sensitize...	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0036064 ciliary basal body	IDA PMID:19596798 Growth arrest induces primary-cilium formation and sensitize...	KEEP AS NON CORE	Summary: ciliary basal body pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005911 cell-cell junction	IDA PMID:23793062 The lymphoid lineage-specific actin-uncapping protein Rltpr ...	KEEP AS NON CORE	Summary: cell-cell junction pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:1901653 cellular response to peptide	IDA PMID:23793062 The lymphoid lineage-specific actin-uncapping protein Rltpr ...	KEEP AS NON CORE	Summary: cellular response to peptide pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA PMID:23610142 Critical role of AZI2 in GM-CSF-induced dendritic cell diffe...	KEEP AS NON CORE	Summary: cellular response to granulocyte macrophage colony-stimulating factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0001938 positive regulation of endothelial cell proliferation	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of endothelial cell proliferation pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:16116448 Bag1 is essential for differentiation and survival of hemato...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005739 mitochondrion	IDA PMID:16116448 Bag1 is essential for differentiation and survival of hemato...	KEEP AS NON CORE	Summary: mitochondrion pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0097194 execution phase of apoptosis	IDA PMID:12124386 The role of Asp-462 in regulating Akt activity.	KEEP AS NON CORE	Summary: execution phase of apoptosis pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0010765 positive regulation of sodium ion transport	ISO GO_REF:0000008	KEEP AS NON CORE	Summary: positive regulation of sodium ion transport pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032869 cellular response to insulin stimulus	ISO GO_REF:0000008	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032880 regulation of protein localization	ISO GO_REF:0000008	KEEP AS NON CORE	Summary: regulation of protein localization pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032287 peripheral nervous system myelin maintenance	IMP PMID:20448149 Dlg1-PTEN interaction regulates myelin thickness to prevent ...	KEEP AS NON CORE	Summary: peripheral nervous system myelin maintenance pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:22057101 ZNRF1 promotes Wallerian degeneration by degrading AKT to in...	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0005515 protein binding	IPI PMID:22057101 ZNRF1 promotes Wallerian degeneration by degrading AKT to in...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0007010 cytoskeleton organization	TAS PMID:22057101 ZNRF1 promotes Wallerian degeneration by degrading AKT to in...	KEEP AS NON CORE	Summary: cytoskeleton organization pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0019901 protein kinase binding	IPI PMID:22057101 ZNRF1 promotes Wallerian degeneration by degrading AKT to in...	MARK AS OVER ANNOTATED	Summary: Generic protein kinase binding annotation Reason: The term is too broad to add useful functional information for AKT1 relative to the more specific kinase, localization, and pathway annotations.
GO:0071364 cellular response to epidermal growth factor stimulus	IDA PMID:21712384 Silencer of death domains (SODD) inhibits skeletal muscle an...	KEEP AS NON CORE	Summary: cellular response to epidermal growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0090201 negative regulation of release of cytochrome c from mitochondria	IDA PMID:18977203 Akt activation prevents Apop-1-induced death of cells.	KEEP AS NON CORE	Summary: negative regulation of release of cytochrome c from mitochondria pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0030334 regulation of cell migration	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of cell migration pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005515 protein binding	IPI PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005634 nucleus	IDA PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates...	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005886 plasma membrane	IDA PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates...	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain. Supporting Evidence: PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
GO:0006468 protein phosphorylation	IDA PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase. Supporting Evidence: PMID:20333297 Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
GO:0005515 protein binding	IPI PMID:21030605 PML regulates apoptosis at endoplasmic reticulum by modulati...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0001649 osteoblast differentiation	IGI PMID:19208758 Akt promotes BMP2-mediated osteoblast differentiation and bo...	KEEP AS NON CORE	Summary: osteoblast differentiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006006 glucose metabolic process	IMP PMID:19897600 Role of insulin-like growth factor-binding protein 5 (IGFBP5...	KEEP AS NON CORE	Summary: glucose metabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0042593 glucose homeostasis	IMP PMID:19897600 Role of insulin-like growth factor-binding protein 5 (IGFBP5...	KEEP AS NON CORE	Summary: glucose homeostasis pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0045944 positive regulation of transcription by RNA polymerase II	IGI PMID:18762576 IGFBP-5 regulates muscle cell differentiation by binding to ...	KEEP AS NON CORE	Summary: positive regulation of transcription by RNA polymerase II pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0051146 striated muscle cell differentiation	IGI PMID:18762576 IGFBP-5 regulates muscle cell differentiation by binding to ...	KEEP AS NON CORE	Summary: striated muscle cell differentiation pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005886 plasma membrane	IDA PMID:15775979 E-cadherin is essential for in vivo epidermal barrier functi...	UNDECIDED	Summary: plasma membrane localization lacks direct support in the cached PMID:15775979 record Reason: The cached E-cadherin/tight-junction source does not directly support an AKT1-specific plasma membrane localization annotation.
GO:0071363 cellular response to growth factor stimulus	IDA PMID:19744960 GIGYF2 gene disruption in mice results in neurodegeneration ...	KEEP AS NON CORE	Summary: cellular response to growth factor stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032869 cellular response to insulin stimulus	IDA PMID:19139280 ClipR-59 interacts with Akt and regulates Akt cellular compa...	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0005515 protein binding	IPI PMID:19139280 ClipR-59 interacts with Akt and regulates Akt cellular compa...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005515 protein binding	IPI PMID:15722337 Phosphorylation of grb10 regulates its interaction with 14-3...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0010975 regulation of neuron projection development	IDA PMID:19778506 DISC1 regulates new neuron development in the adult brain vi...	KEEP AS NON CORE	Summary: regulation of neuron projection development pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0001893 maternal placenta development	IMP PMID:12783884 Protein kinase B alpha/Akt1 regulates placental development ...	KEEP AS NON CORE	Summary: maternal placenta development pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0060709 glycogen cell differentiation involved in embryonic placenta development	IMP PMID:12783884 Protein kinase B alpha/Akt1 regulates placental development ...	KEEP AS NON CORE	Summary: glycogen cell differentiation involved in embryonic placenta development pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0060716 labyrinthine layer blood vessel development	IMP PMID:12783884 Protein kinase B alpha/Akt1 regulates placental development ...	KEEP AS NON CORE	Summary: labyrinthine layer blood vessel development pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005515 protein binding	IPI PMID:16357133 Akt phosphorylates and regulates Pdcd4 tumor suppressor prot...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0010765 positive regulation of sodium ion transport	IDA PMID:17715136 Akt mediates the effect of insulin on epithelial sodium chan...	KEEP AS NON CORE	Summary: positive regulation of sodium ion transport pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0010765 positive regulation of sodium ion transport	IMP PMID:17715136 Akt mediates the effect of insulin on epithelial sodium chan...	KEEP AS NON CORE	Summary: positive regulation of sodium ion transport pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0032869 cellular response to insulin stimulus	IDA PMID:17715136 Akt mediates the effect of insulin on epithelial sodium chan...	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032869 cellular response to insulin stimulus	IMP PMID:17715136 Akt mediates the effect of insulin on epithelial sodium chan...	KEEP AS NON CORE	Summary: cellular response to insulin stimulus pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0032880 regulation of protein localization	IDA PMID:17715136 Akt mediates the effect of insulin on epithelial sodium chan...	KEEP AS NON CORE	Summary: regulation of protein localization pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0006468 protein phosphorylation	IDA PMID:15937334 A role for mitogen-activated protein kinase(Erk1/2) activati...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP PMID:15937334 A role for mitogen-activated protein kinase(Erk1/2) activati...	KEEP AS NON CORE	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0018105 peptidyl-serine phosphorylation	IDA PMID:16513828 Impact of obesity on the growth hormone axis: evidence for a...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0032094 response to food	IDA PMID:16513828 Impact of obesity on the growth hormone axis: evidence for a...	KEEP AS NON CORE	Summary: response to food pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0045792 negative regulation of cell size	ISO PMID:16286931 Regulation of neuronal morphology and function by the tumor ...	KEEP AS NON CORE	Summary: negative regulation of cell size pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0005886 plasma membrane	ISO PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	ACCEPT	Summary: plasma membrane localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.
GO:0006468 protein phosphorylation	ISO PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0006924 activation-induced cell death of T cells	ISO PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	KEEP AS NON CORE	Summary: activation-induced cell death of T cells pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0016301 kinase activity	ISO PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	MARK AS OVER ANNOTATED	Summary: kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0035556 intracellular signal transduction	ISO PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	KEEP AS NON CORE	Summary: intracellular signal transduction pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005515 protein binding	IPI PMID:15753085 A novel protein kinase B (PKB)/AKT-binding protein enhances ...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding does not identify the functional interaction or catalytic role of AKT1 and should not be treated as informative core function.
GO:0005977 glycogen metabolic process	IMP PMID:12783884 Protein kinase B alpha/Akt1 regulates placental development ...	KEEP AS NON CORE	Summary: glycogen metabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI PMID:15249583 The TSC1-2 tumor suppressor controls insulin-PI3K signaling ...	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0004672 protein kinase activity	IDA PMID:16357133 Akt phosphorylates and regulates Pdcd4 tumor suppressor prot...	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0009725 response to hormone	IDA PMID:16357133 Akt phosphorylates and regulates Pdcd4 tumor suppressor prot...	KEEP AS NON CORE	Summary: response to hormone pathway context Reason: This is a valid stimulus context for AKT1 signaling but represents upstream activation or downstream cellular response rather than the core molecular function.
GO:0004674 protein serine/threonine kinase activity	ISS GO_REF:0000024	ACCEPT	Summary: Core AKT1 serine/threonine kinase activity Reason: AKT1 is an AGC protein kinase whose main molecular function is ATP-dependent phosphorylation of serine/threonine residues on downstream substrates. Supporting Evidence: file:mouse/Akt1/Akt1-bioreason-rl-predictions.md A cytoplasmic AGC-type serine/threonine kinase that uses an N-terminal pleckstrin-homology module to dock onto phosphoinositide-enriched membranes
GO:0008286 insulin receptor signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0008286 insulin receptor signaling pathway	IMP PMID:11282895 Reperfusion-activated Akt kinase prevents apoptosis in trans...	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0008286 insulin receptor signaling pathway	IMP PMID:9415393 Physiological role of Akt in insulin-stimulated translocatio...	KEEP AS NON CORE	Summary: insulin receptor signaling pathway pathway context Reason: AKT1 is a central downstream kinase in this pathway, but the pathway term is broader than the gene product core molecular activity.
GO:0043066 negative regulation of apoptotic process	IMP PMID:11282895 Reperfusion-activated Akt kinase prevents apoptosis in trans...	KEEP AS NON CORE	Summary: negative regulation of apoptotic process pathway context Reason: This regulatory term reflects downstream consequences of AKT1 signaling and is not the core molecular activity itself.
GO:0048009 insulin-like growth factor receptor signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: insulin-like growth factor receptor signaling pathway pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004672 protein kinase activity	IDA PMID:15010863 IL2-dependent phosphorylation of 40S ribosomal protein S6 is...	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0004672 protein kinase activity	IDA PMID:14730361 The costimulation-regulated duration of PKB activation contr...	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0006468 protein phosphorylation	IDA PMID:14730361 The costimulation-regulated duration of PKB activation contr...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0006954 inflammatory response	IDA PMID:14730361 The costimulation-regulated duration of PKB activation contr...	KEEP AS NON CORE	Summary: inflammatory response pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005819 spindle	IDA PMID:15509711 Serine-threonine kinases and transcription factors active in...	KEEP AS NON CORE	Summary: spindle pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0004672 protein kinase activity	IDA PMID:15192701 PS1 activates PI3K thus inhibiting GSK-3 activity and tau ov...	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than AKT1 serine/threonine kinase activity Reason: The annotation is directionally correct but over-broad because more specific AKT1 kinase activity terms are present and better capture the function.
GO:0006468 protein phosphorylation	IDA PMID:15192701 PS1 activates PI3K thus inhibiting GSK-3 activity and tau ov...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0008637 apoptotic mitochondrial changes	IDA PMID:12869584 The serine/threonine kinase Pim-2 is a transcriptionally reg...	KEEP AS NON CORE	Summary: apoptotic mitochondrial changes pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0006468 protein phosphorylation	IDA PMID:12145204 Phosphorylation-dependent ubiquitylation and degradation of ...	ACCEPT	Summary: Direct AKT1 phosphorylation activity Reason: This term directly describes the catalytic output of AKT1 as a serine/threonine protein kinase.
GO:0016567 protein ubiquitination	IDA PMID:12145204 Phosphorylation-dependent ubiquitylation and degradation of ...	KEEP AS NON CORE	Summary: protein ubiquitination pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0030163 protein catabolic process	IDA PMID:12145204 Phosphorylation-dependent ubiquitylation and degradation of ...	KEEP AS NON CORE	Summary: protein catabolic process pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0007281 germ cell development	IDA PMID:12140361 Dissection of the c-Kit signaling pathway in mouse primordia...	KEEP AS NON CORE	Summary: germ cell development pathway context Reason: The annotation is compatible with known AKT1 signaling biology but represents a pathway, location, interaction, or phenotype rather than the core catalytic function.
GO:0005737 cytoplasm	IDA PMID:12124386 The role of Asp-462 in regulating Akt activity.	ACCEPT	Summary: cytoplasm localization Reason: AKT1 is a soluble kinase that is cytosolic/cytoplasmic and is recruited to phosphoinositide-enriched plasma membrane signaling sites through its PH domain.

Gene Description

Existing Annotations Review

Core Functions

AKT1 phosphorylates serine and threonine residues on downstream protein substrates after PI3K-dependent membrane recruitment and activation by upstream kinases.

References

Deep Research

Falcon

📚 Additional Documentation

Notes

Bioreason Rl Predictions

Bioreason Rl Review

📄 View Raw YAML