Ang2

UniProt ID: Q64438
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Ang2

Existing Annotations Review

GO Term Evidence Action Reason
GO:0004540 RNA nuclease activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019731 antibacterial humoral response
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045087 innate immune response
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050830 defense response to Gram-positive bacterium
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001525 angiogenesis
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003676 nucleic acid binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003677 DNA binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004518 nuclease activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004519 endonuclease activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004540 RNA nuclease activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005730 nucleolus
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016787 hydrolase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031410 cytoplasmic vesicle
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046872 metal ion binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001525 angiogenesis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001666 response to hypoxia
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001878 response to yeast
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001938 positive regulation of endothelial cell proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002181 cytoplasmic translation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003779 actin binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004540 RNA nuclease activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004549 tRNA-specific ribonuclease activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005507 copper ion binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005604 basement membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005694 chromosome
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005730 nucleolus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006898 receptor-mediated endocytosis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008201 heparin binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009303 rRNA transcription
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009725 response to hormone
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010494 cytoplasmic stress granule
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0015629 actin cytoskeleton
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016477 cell migration
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019731 antibacterial humoral response
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019732 antifungal humoral response
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0023052 signaling
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030139 endocytic vesicle
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032055 negative regulation of translation in response to stress
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032311 angiogenin-PRI complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033554 cellular response to stress
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034063 stress granule assembly
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036416 tRNA stabilization
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042277 peptide binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042327 positive regulation of phosphorylation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042803 protein homodimerization activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043022 ribosome binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045087 innate immune response
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048662 negative regulation of smooth muscle cell proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050714 positive regulation of protein secretion
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050830 defense response to Gram-positive bacterium
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071425 hematopoietic stem cell proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
IMP
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates... 		REMOVE
Summary: MISANNOTATION: This annotation appears to be on the WRONG GENE. PMID:25313067 titled "Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation" is about Angiotensin II (AngII), a peptide hormone, NOT Angiogenin-2 (Ang2, gene symbol confusion). The paper describes how Angiotensin II activates PKC which phosphorylates KLHL3 - the phosphorylation is performed by PKC, not by Angiotensin II itself. Ang2/Angiogenin-2 is a ribonuclease (EC 3.1.27.-) with no involvement in angiotensin signaling or phosphorylation. This annotation should be removed from Angiogenin-2 entirely.
Supporting Evidence:
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
GO:0006468 protein phosphorylation
IDA
PMID:28096417
Phosphorylation by PKC and PKA regulate the kinase activity ... 		REMOVE
Summary: MISANNOTATION: This annotation appears to be on the WRONG GENE. PMID:28096417 titled "Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4" is about Angiotensin II (AngII) signaling, NOT Angiogenin-2 (Ang2). The paper explicitly states "AngII signaling" activates PKC/PKA which then phosphorylate WNK4. The phosphorylation is performed by PKC and PKA, not by Angiotensin II. Ang2/Angiogenin-2 (UniProt Q64438) is a ribonuclease with EC 3.1.27.- activity (UniProt: "Has ribonuclease activity"). There appears to be gene symbol confusion between Ang2 and AngII. This annotation should be removed from Angiogenin-2 entirely.
Supporting Evidence:
PMID:28096417
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
GO:0010467 gene expression
IDA
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
GO:0010467 gene expression
IDA
PMID:28096417
Phosphorylation by PKC and PKA regulate the kinase activity ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:28096417
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
GO:0038166 angiotensin-activated signaling pathway
IDA
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
GO:0070293 renal absorption
IDA
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
GO:0001934 positive regulation of protein phosphorylation
IDA
PMID:29065170
Zinc-finger protein 418 overexpression protects against card... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29065170
eCollection 2017. Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis.
GO:0003300 cardiac muscle hypertrophy
IDA
PMID:29065170
Zinc-finger protein 418 overexpression protects against card... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29065170
eCollection 2017. Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis.
GO:0061049 cell growth involved in cardiac muscle cell development
IDA
PMID:29065170
Zinc-finger protein 418 overexpression protects against card... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29065170
eCollection 2017. Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis.
GO:0004540 RNA nuclease activity
IDA
PMID:23170778
Crystal structures of murine angiogenin-2 and -3-probing 'st... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23170778
Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.
GO:0071333 cellular response to glucose stimulus
IDA
PMID:17670746
High glucose increases angiopoietin-2 transcription in micro... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17670746
2007 Aug 1. High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:17670746
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
PMID:23170778
Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.
PMID:25313067
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.
PMID:28096417
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
PMID:29065170
Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis.

📄 View Raw YAML

 
id: Q64438
gene_symbol: Ang2
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ang2'
existing_annotations:
  - term:
      id: GO:0004540
      label: RNA nuclease activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019731
      label: antibacterial humoral response
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050830
      label: defense response to Gram-positive bacterium
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061844
      label: antimicrobial humoral immune response mediated by antimicrobial 
        peptide
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003676
      label: nucleic acid binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004518
      label: nuclease activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004519
      label: endonuclease activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004540
      label: RNA nuclease activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005730
      label: nucleolus
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016787
      label: hydrolase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031410
      label: cytoplasmic vesicle
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001878
      label: response to yeast
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002181
      label: cytoplasmic translation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003779
      label: actin binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004540
      label: RNA nuclease activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004549
      label: tRNA-specific ribonuclease activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005507
      label: copper ion binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005604
      label: basement membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005694
      label: chromosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005730
      label: nucleolus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006898
      label: receptor-mediated endocytosis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008201
      label: heparin binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009303
      label: rRNA transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009725
      label: response to hormone
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010494
      label: cytoplasmic stress granule
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0015629
      label: actin cytoskeleton
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016477
      label: cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019731
      label: antibacterial humoral response
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019732
      label: antifungal humoral response
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0023052
      label: signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030139
      label: endocytic vesicle
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032055
      label: negative regulation of translation in response to stress
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032311
      label: angiogenin-PRI complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033554
      label: cellular response to stress
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034063
      label: stress granule assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036416
      label: tRNA stabilization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042277
      label: peptide binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042327
      label: positive regulation of phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043022
      label: ribosome binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045087
      label: innate immune response
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048662
      label: negative regulation of smooth muscle cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050714
      label: positive regulation of protein secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050830
      label: defense response to Gram-positive bacterium
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061844
      label: antimicrobial humoral immune response mediated by antimicrobial 
        peptide
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071425
      label: hematopoietic stem cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:25313067
    review:
      summary: >-
        MISANNOTATION: This annotation appears to be on the WRONG GENE. PMID:25313067
        titled
        "Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3,
        preventing
        WNK4 degradation" is about Angiotensin II (AngII), a peptide hormone, NOT
        Angiogenin-2
        (Ang2, gene symbol confusion). The paper describes how Angiotensin II activates
        PKC
        which phosphorylates KLHL3 - the phosphorylation is performed by PKC, not
        by
        Angiotensin II itself. Ang2/Angiogenin-2 is a ribonuclease (EC 3.1.27.-) with
        no
        involvement in angiotensin signaling or phosphorylation. This annotation should
        be
        removed from Angiogenin-2 entirely.
      action: REMOVE
      supported_by:
        - reference_id: PMID:25313067
          supporting_text: Angiotensin II signaling via protein kinase C 
            phosphorylates Kelch-like 3, preventing WNK4 degradation.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:28096417
    review:
      summary: >-
        MISANNOTATION: This annotation appears to be on the WRONG GENE. PMID:28096417
        titled
        "Phosphorylation by PKC and PKA regulate the kinase activity and downstream
        signaling
        of WNK4" is about Angiotensin II (AngII) signaling, NOT Angiogenin-2 (Ang2).
        The paper
        explicitly states "AngII signaling" activates PKC/PKA which then phosphorylate
        WNK4.
        The phosphorylation is performed by PKC and PKA, not by Angiotensin II. Ang2/Angiogenin-2
        (UniProt Q64438) is a ribonuclease with EC 3.1.27.- activity (UniProt: "Has
        ribonuclease
        activity"). There appears to be gene symbol confusion between Ang2 and AngII.
        This
        annotation should be removed from Angiogenin-2 entirely.
      action: REMOVE
      supported_by:
        - reference_id: PMID:28096417
          supporting_text: Phosphorylation by PKC and PKA regulate the kinase 
            activity and downstream signaling of WNK4.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:25313067
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25313067
          supporting_text: Angiotensin II signaling via protein kinase C 
            phosphorylates Kelch-like 3, preventing WNK4 degradation.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:28096417
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28096417
          supporting_text: Phosphorylation by PKC and PKA regulate the kinase 
            activity and downstream signaling of WNK4.
  - term:
      id: GO:0038166
      label: angiotensin-activated signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:25313067
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25313067
          supporting_text: Angiotensin II signaling via protein kinase C 
            phosphorylates Kelch-like 3, preventing WNK4 degradation.
  - term:
      id: GO:0070293
      label: renal absorption
    evidence_type: IDA
    original_reference_id: PMID:25313067
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25313067
          supporting_text: Angiotensin II signaling via protein kinase C 
            phosphorylates Kelch-like 3, preventing WNK4 degradation.
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:29065170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29065170
          supporting_text: eCollection 2017. Zinc-finger protein 418 
            overexpression protects against cardiac hypertrophy and fibrosis.
  - term:
      id: GO:0003300
      label: cardiac muscle hypertrophy
    evidence_type: IDA
    original_reference_id: PMID:29065170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29065170
          supporting_text: eCollection 2017. Zinc-finger protein 418 
            overexpression protects against cardiac hypertrophy and fibrosis.
  - term:
      id: GO:0061049
      label: cell growth involved in cardiac muscle cell development
    evidence_type: IDA
    original_reference_id: PMID:29065170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29065170
          supporting_text: eCollection 2017. Zinc-finger protein 418 
            overexpression protects against cardiac hypertrophy and fibrosis.
  - term:
      id: GO:0004540
      label: RNA nuclease activity
    evidence_type: IDA
    original_reference_id: PMID:23170778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23170778
          supporting_text: Crystal structures of murine angiogenin-2 and 
            -3-probing 'structure--function' relationships amongst angiogenin 
            homologues.
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: IDA
    original_reference_id: PMID:17670746
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17670746
          supporting_text: 2007 Aug 1. High glucose increases angiopoietin-2 
            transcription in microvascular endothelial cells through 
            methylglyoxal modification of mSin3A.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:17670746
    title: High glucose increases angiopoietin-2 transcription in microvascular 
      endothelial cells through methylglyoxal modification of mSin3A.
    findings: []
  - id: PMID:23170778
    title: Crystal structures of murine angiogenin-2 and -3-probing 
      'structure--function' relationships amongst angiogenin homologues.
    findings: []
  - id: PMID:25313067
    title: Angiotensin II signaling via protein kinase C phosphorylates 
      Kelch-like 3, preventing WNK4 degradation.
    findings: []
  - id: PMID:28096417
    title: Phosphorylation by PKC and PKA regulate the kinase activity and 
      downstream signaling of WNK4.
    findings: []
  - id: PMID:29065170
    title: Zinc-finger protein 418 overexpression protects against cardiac 
      hypertrophy and fibrosis.
    findings: []