Calmodulin-1 is a ubiquitous calcium-binding messenger protein that serves as the primary intracellular calcium sensor in eukaryotic cells. Through its four EF-hand domains, Calm1 binds calcium ions and undergoes conformational changes enabling interaction with and regulation of over 100 target proteins including kinases (CaMKII), phosphatases (calcineurin), ion channels (RyR1, RyR2, SCN8A), and cytoskeletal proteins (MYO5A). Essential for calcium signal transduction, muscle contraction, cardiac function, and neurotransmission. Highly conserved - identical in sequence to human CALM1, CALM2, and CALM3. Mitotic spindle, centrosome, and cytokinesis annotations are retained as supported non-core contexts.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005509 calcium ion binding | IBA GO_REF:0000033 | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization |
| GO:0005634 nucleus | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Nuclear localization in some contexts Reason: Tissue-specific or specialized function |
| GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IBA GO_REF:0000033 | ACCEPT | Summary: Regulates RyR-mediated calcium release from SR Reason: Core calmodulin function or localization |
| GO:0005513 detection of calcium ion | IBA GO_REF:0000033 | ACCEPT | Summary: Core calcium sensing function Reason: Core calmodulin function or localization |
| GO:0097720 calcineurin-mediated signaling | IBA GO_REF:0000033 | ACCEPT | Summary: Activates calcineurin phosphatase for NFAT signaling Reason: Core calmodulin function or localization |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Primary cytoplasmic localization Reason: Core calmodulin function or localization |
| GO:0005813 centrosome | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Centrosomal localization for cell division Reason: Tissue-specific or specialized function |
| GO:0043209 myelin sheath | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Myelin sheath localization Reason: Tissue-specific or specialized function |
| GO:0000086 G2/M transition of mitotic cell cycle | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Cell cycle regulation at G2/M transition Reason: Tissue-specific or specialized function |
| GO:0000922 spindle pole | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Spindle pole localization during mitosis Reason: Tissue-specific or specialized function |
| GO:0005509 calcium ion binding | IEA GO_REF:0000120 | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization |
| GO:0005813 centrosome | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Centrosomal localization for cell division Reason: Tissue-specific or specialized function |
| GO:0005819 spindle | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Spindle localization for cell division Reason: Tissue-specific or specialized function |
| GO:0006897 endocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Endocytosis regulation Reason: Tissue-specific or specialized function |
| GO:0031514 motile cilium | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Ciliary localization Reason: Tissue-specific or specialized function |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Parent term - too general Reason: Too general - more specific terms are available |
| GO:0051649 establishment of localization in cell | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Intracellular localization establishment Reason: Tissue-specific or specialized function |
| GO:0150034 distal axon | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Distal axon localization Reason: Tissue-specific or specialized function |
| GO:0000785 chromatin | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Chromatin association Reason: Tissue-specific or specialized function |
| GO:0001975 response to amphetamine | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Amphetamine response in neurons Reason: Tissue-specific or specialized function |
| GO:0002027 regulation of heart rate | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Heart-rate physiology is a downstream tissue-level consequence of calmodulin ion-channel regulation, not the primary molecular function of Calm1. Reason: Tissue-specific or specialized function |
| GO:0005246 calcium channel regulator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Regulates L-type calcium channels and ryanodine receptors Reason: Core calmodulin function or localization |
| GO:0005513 detection of calcium ion | IEA GO_REF:0000120 | ACCEPT | Summary: Core calcium sensing function Reason: Core calmodulin function or localization |
| GO:0005634 nucleus | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Nuclear localization in some contexts Reason: Tissue-specific or specialized function |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: Primary cytoplasmic localization Reason: Core calmodulin function or localization |
| GO:0005829 cytosol | IEA GO_REF:0000120 | ACCEPT | Summary: Soluble cytosolic protein Reason: Core calmodulin function or localization |
| GO:0005876 spindle microtubule | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Spindle microtubule association Reason: Tissue-specific or specialized function |
| GO:0008179 adenylate cyclase binding | IEA GO_REF:0000120 | ACCEPT | Summary: Binds adenylate cyclase Reason: Core calmodulin function or localization |
| GO:0010856 adenylate cyclase activator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Activates adenylate cyclase for cAMP signaling Reason: Core calmodulin function or localization |
| GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IEA GO_REF:0000120 | ACCEPT | Summary: Regulates RyR-mediated calcium release from SR Reason: Core calmodulin function or localization |
| GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Cardiac calcium-induced calcium release is a tissue-specific physiological context downstream of calmodulin channel regulation. Reason: Tissue-specific or specialized function |
| GO:0016240 autophagosome membrane docking | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Autophagosome docking regulation Reason: Tissue-specific or specialized function |
| GO:0019855 calcium channel inhibitor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Inhibits IP3 receptors and certain calcium channels Reason: Core calmodulin function or localization |
| GO:0019901 protein kinase binding | IEA GO_REF:0000120 | ACCEPT | Summary: Binds CaMK family and other protein kinases Reason: Core calmodulin function or localization |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: IQ motif and calmodulin-binding domain recognition Reason: Tissue-specific or specialized function |
| GO:0030017 sarcomere | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Sarcomere localization in muscle Reason: Tissue-specific or specialized function |
| GO:0030235 nitric-oxide synthase regulator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Regulates NOS enzymes Reason: Core calmodulin function or localization |
| GO:0030426 growth cone | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Neuronal growth cone localization Reason: Tissue-specific or specialized function |
| GO:0030672 synaptic vesicle membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Synaptic vesicle localization Reason: Tissue-specific or specialized function |
| GO:0031432 titin binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Titin binding in muscle Reason: Tissue-specific or specialized function |
| GO:0031800 type 3 metabotropic glutamate receptor binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: mGluR3 binding in neurons Reason: Tissue-specific or specialized function |
| GO:0031966 mitochondrial membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Mitochondrial membrane association Reason: Tissue-specific or specialized function |
| GO:0032465 regulation of cytokinesis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Cytokinesis regulation with CP110 and centrin Reason: Tissue-specific or specialized function |
| GO:0032991 protein-containing complex | IEA GO_REF:0000120 | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available |
| GO:0034704 calcium channel complex | IEA GO_REF:0000120 | ACCEPT | Summary: Component of calcium channel complexes Reason: Core calmodulin function or localization |
| GO:0035458 cellular response to interferon-beta | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Interferon-beta response Reason: Tissue-specific or specialized function |
| GO:0043209 myelin sheath | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Myelin sheath localization Reason: Tissue-specific or specialized function |
| GO:0043539 protein serine/threonine kinase activator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Activates CaMKII and other calcium-dependent kinases Reason: Core calmodulin function or localization |
| GO:0043548 phosphatidylinositol 3-kinase binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: PI3K binding for signaling Reason: Tissue-specific or specialized function |
| GO:0044325 transmembrane transporter binding | IEA GO_REF:0000120 | ACCEPT | Summary: Binds ion channels and transporters Reason: Core calmodulin function or localization |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: JAK-STAT pathway regulation Reason: Tissue-specific or specialized function |
| GO:0048306 calcium-dependent protein binding | IEA GO_REF:0000120 | ACCEPT | Summary: Calcium-dependent target protein binding Reason: Core calmodulin function or localization |
| GO:0050998 nitric-oxide synthase binding | IEA GO_REF:0000120 | ACCEPT | Summary: Binds NOS for activation Reason: Core calmodulin function or localization |
| GO:0051412 response to corticosterone | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Corticosterone response Reason: Tissue-specific or specialized function |
| GO:0051592 response to calcium ion | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Response to calcium ion Reason: Tissue-specific or specialized function |
| GO:0055117 regulation of cardiac muscle contraction | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Cardiac contraction is a downstream tissue-level process; the direct supported function is calcium/channel regulation. Reason: Tissue-specific or specialized function |
| GO:0071346 cellular response to type II interferon | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Interferon-gamma response Reason: Tissue-specific or specialized function |
| GO:0072542 protein phosphatase activator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Activates calcineurin (PP2B) phosphatase Reason: Core calmodulin function or localization |
| GO:0090150 establishment of protein localization to membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Membrane protein localization Reason: Tissue-specific or specialized function |
| GO:0090151 obsolete establishment of protein localization to mitochondrial membrane | IEA GO_REF:0000120 | REMOVE | Summary: Term is obsolete - should be removed Reason: GO term is obsolete |
| GO:0097720 calcineurin-mediated signaling | IEA GO_REF:0000120 | ACCEPT | Summary: Activates calcineurin phosphatase for NFAT signaling Reason: Core calmodulin function or localization |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Hippocampal synapse localization Reason: Tissue-specific or specialized function |
| GO:0098901 regulation of cardiac muscle cell action potential | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Cardiac action potential regulation Reason: Tissue-specific or specialized function |
| GO:0099523 presynaptic cytosol | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Presynaptic localization Reason: Tissue-specific or specialized function |
| GO:0099524 postsynaptic cytosol | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Postsynaptic localization Reason: Tissue-specific or specialized function |
| GO:0140056 organelle localization by membrane tethering | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Organelle membrane tethering Reason: Tissue-specific or specialized function |
| GO:1900242 regulation of synaptic vesicle endocytosis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Synaptic vesicle endocytosis regulation Reason: Tissue-specific or specialized function |
| GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Cardiac electrical coupling regulation Reason: Tissue-specific or specialized function |
| GO:1902494 catalytic complex | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Part of enzyme complexes Reason: Tissue-specific or specialized function |
| GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ER-mitochondria contact regulation Reason: Tissue-specific or specialized function |
| GO:2000300 regulation of synaptic vesicle exocytosis | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Synaptic vesicle exocytosis regulation Reason: Tissue-specific or specialized function |
| GO:0000922 spindle pole | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Spindle pole localization during mitosis Reason: Tissue-specific or specialized function |
| GO:0002027 regulation of heart rate | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Heart-rate physiology is a downstream tissue-level consequence of calmodulin ion-channel regulation, not the primary molecular function of Calm1. Reason: Tissue-specific or specialized function |
| GO:0005246 calcium channel regulator activity | ISO GO_REF:0000119 | ACCEPT | Summary: Regulates L-type calcium channels and ryanodine receptors Reason: Core calmodulin function or localization |
| GO:0005509 calcium ion binding | ISO GO_REF:0000119 | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization |
| GO:0005513 detection of calcium ion | ISO GO_REF:0000119 | ACCEPT | Summary: Core calcium sensing function Reason: Core calmodulin function or localization |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Primary cytoplasmic localization Reason: Core calmodulin function or localization |
| GO:0005813 centrosome | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Centrosomal localization for cell division Reason: Tissue-specific or specialized function |
| GO:0005829 cytosol | ISO GO_REF:0000119 | ACCEPT | Summary: Soluble cytosolic protein Reason: Core calmodulin function or localization |
| GO:0005876 spindle microtubule | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Spindle microtubule association Reason: Tissue-specific or specialized function |
| GO:0010856 adenylate cyclase activator activity | ISO GO_REF:0000119 | ACCEPT | Summary: Activates adenylate cyclase for cAMP signaling Reason: Core calmodulin function or localization |
| GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | ISO GO_REF:0000119 | ACCEPT | Summary: Regulates RyR-mediated calcium release from SR Reason: Core calmodulin function or localization |
| GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Cardiac calcium-induced calcium release is a tissue-specific physiological context downstream of calmodulin channel regulation. Reason: Tissue-specific or specialized function |
| GO:0016240 autophagosome membrane docking | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Autophagosome docking regulation Reason: Tissue-specific or specialized function |
| GO:0019855 calcium channel inhibitor activity | ISO GO_REF:0000119 | ACCEPT | Summary: Inhibits IP3 receptors and certain calcium channels Reason: Core calmodulin function or localization |
| GO:0019901 protein kinase binding | ISO GO_REF:0000119 | ACCEPT | Summary: Binds CaMK family and other protein kinases Reason: Core calmodulin function or localization |
| GO:0030017 sarcomere | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Sarcomere localization in muscle Reason: Tissue-specific or specialized function |
| GO:0031432 titin binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Titin binding in muscle Reason: Tissue-specific or specialized function |
| GO:0032465 regulation of cytokinesis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Cytokinesis regulation with CP110 and centrin Reason: Tissue-specific or specialized function |
| GO:0032991 protein-containing complex | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available |
| GO:0034704 calcium channel complex | ISO GO_REF:0000119 | ACCEPT | Summary: Component of calcium channel complexes Reason: Core calmodulin function or localization |
| GO:0035458 cellular response to interferon-beta | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Interferon-beta response Reason: Tissue-specific or specialized function |
| GO:0043539 protein serine/threonine kinase activator activity | ISO GO_REF:0000119 | ACCEPT | Summary: Activates CaMKII and other calcium-dependent kinases Reason: Core calmodulin function or localization |
| GO:0044325 transmembrane transporter binding | ISO GO_REF:0000119 | ACCEPT | Summary: Binds ion channels and transporters Reason: Core calmodulin function or localization |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: JAK-STAT pathway regulation Reason: Tissue-specific or specialized function |
| GO:0051592 response to calcium ion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Response to calcium ion Reason: Tissue-specific or specialized function |
| GO:0055117 regulation of cardiac muscle contraction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Cardiac contraction is a downstream tissue-level process; the direct supported function is calcium/channel regulation. Reason: Tissue-specific or specialized function |
| GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity | ISO GO_REF:0000119 | ACCEPT | Summary: Regulates RyR1 and RyR2 activity Reason: Core calmodulin function or localization |
| GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity | ISO GO_REF:0000119 | ACCEPT | Summary: Inhibits ryanodine receptor under certain conditions Reason: Core calmodulin function or localization |
| GO:0071346 cellular response to type II interferon | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Interferon-gamma response Reason: Tissue-specific or specialized function |
| GO:0072542 protein phosphatase activator activity | ISO GO_REF:0000119 | ACCEPT | Summary: Activates calcineurin (PP2B) phosphatase Reason: Core calmodulin function or localization |
| GO:0097720 calcineurin-mediated signaling | ISO GO_REF:0000119 | ACCEPT | Summary: Activates calcineurin phosphatase for NFAT signaling Reason: Core calmodulin function or localization |
| GO:0098901 regulation of cardiac muscle cell action potential | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Cardiac action potential regulation Reason: Tissue-specific or specialized function |
| GO:0140056 organelle localization by membrane tethering | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Organelle membrane tethering Reason: Tissue-specific or specialized function |
| GO:1901842 negative regulation of high voltage-gated calcium channel activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Calcium channel activity regulation Reason: Tissue-specific or specialized function |
| GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Cardiac electrical coupling regulation Reason: Tissue-specific or specialized function |
| GO:1902494 catalytic complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Part of enzyme complexes Reason: Tissue-specific or specialized function |
| GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: ER-mitochondria contact regulation Reason: Tissue-specific or specialized function |
| GO:0000785 chromatin | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Chromatin association Reason: Tissue-specific or specialized function |
| GO:0005509 calcium ion binding | ISO GO_REF:0000096 | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization |
| GO:0005634 nucleus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Nuclear localization in some contexts Reason: Tissue-specific or specialized function |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: JAK-STAT signaling pathway Reason: Tissue-specific or specialized function |
| GO:0019904 protein domain specific binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: IQ motif and calmodulin-binding domain recognition Reason: Tissue-specific or specialized function |
| GO:0030235 nitric-oxide synthase regulator activity | ISO GO_REF:0000096 | ACCEPT | Summary: Regulates NOS enzymes Reason: Core calmodulin function or localization |
| GO:0030426 growth cone | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Neuronal growth cone localization Reason: Tissue-specific or specialized function |
| GO:0030672 synaptic vesicle membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic vesicle localization Reason: Tissue-specific or specialized function |
| GO:0031800 type 3 metabotropic glutamate receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: mGluR3 binding in neurons Reason: Tissue-specific or specialized function |
| GO:0031966 mitochondrial membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Mitochondrial membrane association Reason: Tissue-specific or specialized function |
| GO:0043209 myelin sheath | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Myelin sheath localization Reason: Tissue-specific or specialized function |
| GO:0043548 phosphatidylinositol 3-kinase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: PI3K binding for signaling Reason: Tissue-specific or specialized function |
| GO:0044325 transmembrane transporter binding | ISO GO_REF:0000096 | ACCEPT | Summary: Binds ion channels and transporters Reason: Core calmodulin function or localization |
| GO:0048306 calcium-dependent protein binding | ISO GO_REF:0000096 | ACCEPT | Summary: Calcium-dependent target protein binding Reason: Core calmodulin function or localization |
| GO:0050998 nitric-oxide synthase binding | ISO GO_REF:0000096 | ACCEPT | Summary: Binds NOS for activation Reason: Core calmodulin function or localization |
| GO:0098685 Schaffer collateral - CA1 synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Hippocampal synapse localization Reason: Tissue-specific or specialized function |
| GO:0099523 presynaptic cytosol | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Presynaptic localization Reason: Tissue-specific or specialized function |
| GO:0099524 postsynaptic cytosol | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Postsynaptic localization Reason: Tissue-specific or specialized function |
| GO:0005515 protein binding | IPI PMID:10620513 Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2... | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available Supporting Evidence: PMID:10620513 Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors. |
| GO:0005515 protein binding | IPI PMID:11955285 Localization and function of a calmodulin-apocalmodulin-bind... | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available Supporting Evidence: PMID:11955285 Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor. |
| GO:0044305 calyx of Held | NAS PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Calyx of Held synapse localization Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0044305 calyx of Held | IMP PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Calyx of Held synapse localization Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0044305 calyx of Held | IDA PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Calyx of Held synapse localization Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0140238 presynaptic endocytosis | NAS PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Presynaptic vesicle endocytosis Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0140238 presynaptic endocytosis | IMP PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Presynaptic vesicle endocytosis Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0140238 presynaptic endocytosis | IDA PMID:31628181 Protein Kinase C and Calmodulin Serve As Calcium Sensors for... | KEEP AS NON CORE | Summary: Presynaptic vesicle endocytosis Reason: Tissue-specific or specialized function Supporting Evidence: PMID:31628181 Epub 2019 Oct 18. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. |
| GO:0005515 protein binding | IPI PMID:29025071 The expression characteristics of FAM71D and its association... | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available Supporting Evidence: PMID:29025071 The expression characteristics of FAM71D and its association with sperm motility. |
| GO:0097225 sperm midpiece | IDA PMID:29025071 The expression characteristics of FAM71D and its association... | KEEP AS NON CORE | Summary: Sperm midpiece localization Reason: Tissue-specific or specialized function Supporting Evidence: PMID:29025071 The expression characteristics of FAM71D and its association with sperm motility. |
| GO:0005515 protein binding | IPI PMID:31088288 The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc-... | MARK AS OVER ANNOTATED | Summary: Too general - more specific terms available Reason: Too general - more specific terms are available Supporting Evidence: PMID:31088288 Epub 2019 Jun 24. The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. |
| GO:0016240 autophagosome membrane docking | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Autophagosome docking regulation Reason: Tissue-specific or specialized function |
| GO:0140056 organelle localization by membrane tethering | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Organelle membrane tethering Reason: Tissue-specific or specialized function |
| GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ER-mitochondria contact regulation Reason: Tissue-specific or specialized function |
| GO:0043209 myelin sheath | IDA PMID:19855925 Structural analysis of the complex between calmodulin and fu... | KEEP AS NON CORE | Summary: Myelin sheath localization Reason: Tissue-specific or specialized function Supporting Evidence: PMID:19855925 Oct 24. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9005848 | KEEP AS NON CORE | Summary: Nucleoplasm localization Reason: Tissue-specific or specialized function |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9005872 | KEEP AS NON CORE | Summary: Nucleoplasm localization Reason: Tissue-specific or specialized function |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9007015 | KEEP AS NON CORE | Summary: Nucleoplasm localization Reason: Tissue-specific or specialized function |
| GO:0005829 cytosol | TAS Reactome:R-MMU-2025936 | ACCEPT | Summary: Soluble cytosolic protein Reason: Core calmodulin function or localization |
| GO:0005829 cytosol | TAS Reactome:R-MMU-2316348 | ACCEPT | Summary: Soluble cytosolic protein Reason: Core calmodulin function or localization |
| GO:0005829 cytosol | TAS Reactome:R-MMU-2316351 | ACCEPT | Summary: Soluble cytosolic protein Reason: Core calmodulin function or localization |
| GO:0005509 calcium ion binding | ISS GO_REF:0000024 | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Primary cytoplasmic localization Reason: Core calmodulin function or localization |
| GO:0019855 calcium channel inhibitor activity | ISS GO_REF:0000024 | ACCEPT | Summary: Inhibits IP3 receptors and certain calcium channels Reason: Core calmodulin function or localization |
| GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity | ISS GO_REF:0000024 | ACCEPT | Summary: Regulates RyR1 and RyR2 activity Reason: Core calmodulin function or localization |
| GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity | ISS GO_REF:0000024 | ACCEPT | Summary: Inhibits ryanodine receptor under certain conditions Reason: Core calmodulin function or localization |
| GO:0008076 voltage-gated potassium channel complex | IGI PMID:12223552 Calmodulin is an auxiliary subunit of KCNQ2/3 potassium chan... | KEEP AS NON CORE | Summary: KCNQ channel complex component Reason: Tissue-specific or specialized function Supporting Evidence: PMID:12223552 Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. |
| GO:0000086 G2/M transition of mitotic cell cycle | IDA PMID:2469574 Calmodulin is required for cell-cycle progression during G1 ... | KEEP AS NON CORE | Summary: Cell cycle regulation at G2/M transition Reason: Tissue-specific or specialized function Supporting Evidence: PMID:2469574 Calmodulin is required for cell-cycle progression during G1 and mitosis. |
| GO:0005509 calcium ion binding | TAS PMID:2469574 Calmodulin is required for cell-cycle progression during G1 ... | ACCEPT | Summary: Core calcium-binding function through 4 EF-hand domains Reason: Core calmodulin function or localization Supporting Evidence: PMID:2469574 Calmodulin is required for cell-cycle progression during G1 and mitosis. file:mouse/Calm1/Calm1-deep-research-falcon.md Deep research synthesis supports Calm1 as a canonical four-EF-hand calcium sensor with gene-specific regulation dominated by transcript-level control rather than a distinct protein sequence. |
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