Calcium/calmodulin-dependent protein kinase type II alpha subunit (CaMKIIΞ±). Functions as a serine/threonine kinase activated by Ca2+/calmodulin binding. Autophosphorylation at Thr-286 confers constitutive Ca2+-independent activity. Critical for synaptic plasticity, learning, and memory in the brain. Regulates NMDA receptor signaling, AMPA receptor trafficking, and dendritic spine development. Also involved in neuronal migration, endocannabinoid signaling, and JAK-STAT pathway activation.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004683 calcium/calmodulin-dependent protein kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: UniProt:P11798 FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: cytoplasm Reason: Specialized cellular process Supporting Evidence: UniProt:P11798 SUBCELLULAR LOCATION: |
| GO:0014069 postsynaptic density | IBA GO_REF:0000033 | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function Supporting Evidence: UniProt:P11798 GO; GO:0014069; C:postsynaptic density; IDA:MGI. |
| GO:0048168 regulation of neuronal synaptic plasticity | IBA GO_REF:0000033 | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function Supporting Evidence: UniProt:P11798 FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity |
| GO:1903076 regulation of protein localization to plasma membrane | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0043005 neuron projection | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0005516 calmodulin binding | IBA GO_REF:0000033 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: UniProt:P11798 GO; GO:0005516; F:calmodulin binding; IDA:CAFA. |
| GO:0000082 G1/S transition of mitotic cell cycle | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: G1/S transition of mitotic cell cycle Reason: Specialized cellular process |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: protein kinase activity Reason: Specialized cellular process |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000043 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0004683 calcium/calmodulin-dependent protein kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0005516 calmodulin binding | IEA GO_REF:0000120 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: UniProt:P11798 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: cytoplasm Reason: Specialized cellular process |
| GO:0006816 calcium ion transport | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: calcium ion transport Reason: Specialized cellular process |
| GO:0014069 postsynaptic density | IEA GO_REF:0000044 | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function |
| GO:0016301 kinase activity | IEA GO_REF:0000043 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | ACCEPT | Summary: Core kinase function Reason: Defines essential CaMKII catalytic activity |
| GO:0030425 dendrite | IEA GO_REF:0000044 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: UniProt:P11798 Regulates dendritic spine development (By similarity). |
| GO:0043197 dendritic spine | IEA GO_REF:0000044 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: UniProt:P11798 GO; GO:0043197; C:dendritic spine; ISS:UniProtKB. |
| GO:0043226 organelle | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative |
| GO:0045202 synapse | IEA GO_REF:0000044 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | ACCEPT | Summary: Core kinase function Reason: Defines essential CaMKII catalytic activity |
| GO:0005515 protein binding | IPI PMID:10862698 Proteomic analysis of NMDA receptor-adhesion protein signali... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:10862698 Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |
| GO:0005515 protein binding | IPI PMID:16120608 Multivalent interactions of calcium/calmodulin-dependent pro... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:16120608 2005 Aug 24. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. |
| GO:0005515 protein binding | IPI PMID:16710293 NR2B tyrosine phosphorylation modulates fear learning as wel... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:16710293 May 18. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. |
| GO:0005515 protein binding | IPI PMID:19455133 Targeted tandem affinity purification of PSD-95 recovers cor... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:19455133 Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. |
| GO:0005515 protein binding | IPI PMID:20141836 DAPK1 interaction with NMDA receptor NR2B subunits mediates ... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:20141836 DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. |
| GO:0005515 protein binding | IPI PMID:22234183 CaMKII binding to GluN2B is critical during memory consolida... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:22234183 CaMKII binding to GluN2B is critical during memory consolidation. |
| GO:0005515 protein binding | IPI PMID:24725413 Activity-dependent p25 generation regulates synaptic plastic... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:24725413 Activity-dependent p25 generation regulates synaptic plasticity and AΞ²-induced cognitive impairment. |
| GO:0005515 protein binding | IPI PMID:28130356 A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology ... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:28130356 Epub 2017 Jan 27. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. |
| GO:0005515 protein binding | IPI PMID:28671696 Spatiotemporal profile of postsynaptic interactomes integrat... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:28671696 Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. |
| GO:0004674 protein serine/threonine kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0004683 calcium/calmodulin-dependent protein kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0005516 calmodulin binding | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0005954 calcium- and calmodulin-dependent protein kinase complex | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Defines essential CaMKII catalytic activity |
| GO:0006468 protein phosphorylation | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0016301 kinase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0035458 cellular response to interferon-beta | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0038166 angiotensin-activated signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0042802 identical protein binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative |
| GO:0042803 protein homodimerization activity | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative |
| GO:0043197 dendritic spine | ISO GO_REF:0000119 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0060996 dendritic spine development | ISO GO_REF:0000119 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:0071346 cellular response to type II interferon | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0110076 negative regulation of ferroptosis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of ferroptosis Reason: Specialized cellular process |
| GO:1990443 peptidyl-threonine autophosphorylation | ISO GO_REF:0000119 | ACCEPT | Summary: Core kinase function Reason: Defines essential CaMKII catalytic activity |
| GO:2001222 regulation of neuron migration | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endoca... | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endocannabinoid signaling. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:28130356 A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology ... | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: PMID:28130356 Epub 2017 Jan 27. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. |
| GO:0006468 protein phosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0018105 peptidyl-serine phosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0046777 protein autophosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0004683 calcium/calmodulin-dependent protein kinase activity | ISO GO_REF:0000096 | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0014069 postsynaptic density | ISO GO_REF:0000096 | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function |
| GO:0030424 axon | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0030425 dendrite | ISO GO_REF:0000096 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:0032794 GTPase activating protein binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: GTPase activating protein binding Reason: Specialized cellular process |
| GO:0032839 dendrite cytoplasm | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0035235 ionotropic glutamate receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0043025 neuronal cell body | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0098877 neurotransmitter receptor transport to plasma membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0098978 glutamatergic synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0099523 presynaptic cytosol | ISO GO_REF:0000096 | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function |
| GO:0099524 postsynaptic cytosol | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:1903076 regulation of protein localization to plasma membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0110076 negative regulation of ferroptosis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of ferroptosis Reason: Specialized cellular process |
| GO:0098685 Schaffer collateral - CA1 synapse | IMP PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent pr... | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. |
| GO:0098685 Schaffer collateral - CA1 synapse | IDA PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent pr... | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. |
| GO:0099148 regulation of synaptic vesicle docking | IMP PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent pr... | MODIFY | Summary: Presynaptic, kinase-independent regulation of docked-vesicle number and short-term plasticity at CA3-CA1 synapses; the annotated term is now obsolete. Reason: GO:0099148 regulation of synaptic vesicle docking was obsoleted (GO release 2026-07-26) because synaptic vesicle docking is now represented as the molecular function GO:0160321 vesicle docking activity. CaMKIIalpha is not itself a docking adaptor; PMID:17660813 shows it regulates the number of docked vesicles and is required for normal short-term presynaptic plasticity through a nonenzymatic role, so the finding is best carried by the live regulatory process GO:0048172 regulation of short-term neuronal synaptic plasticity rather than transferred to the docking-activity MF. Proposed replacements: regulation of short-term neuronal synaptic plasticity Supporting Evidence: PMID:17660813 alphaCaMKII regulates the number of docked vesicles independent of its ability to be activated PMID:17660813 is required for normal short-term presynaptic plasticity |
| GO:0099148 regulation of synaptic vesicle docking | IDA PMID:17660813 Kinase activity is not required for alphaCaMKII-dependent pr... | MODIFY | Summary: Presynaptic, kinase-independent regulation of docked-vesicle number and short-term plasticity at CA3-CA1 synapses; the annotated term is now obsolete. Reason: GO:0099148 regulation of synaptic vesicle docking was obsoleted (GO release 2026-07-26) because synaptic vesicle docking is now represented as the molecular function GO:0160321 vesicle docking activity. CaMKIIalpha is not itself a docking adaptor; PMID:17660813 shows it regulates the number of docked vesicles and is required for normal short-term presynaptic plasticity through a nonenzymatic role, so the finding is best carried by the live regulatory process GO:0048172 regulation of short-term neuronal synaptic plasticity rather than transferred to the docking-activity MF. Proposed replacements: regulation of short-term neuronal synaptic plasticity Supporting Evidence: PMID:17660813 alphaCaMKII regulates the number of docked vesicles independent of its ability to be activated PMID:17660813 is required for normal short-term presynaptic plasticity |
| GO:0035458 cellular response to interferon-beta | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role |
| GO:0045202 synapse | IDA PMID:28642476 Prevention of long-term memory loss after retrieval by an en... | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: PMID:28642476 Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor. |
| GO:0048168 regulation of neuronal synaptic plasticity | IMP PMID:17610578 Alpha-synuclein involvement in hippocampal synaptic plastici... | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function Supporting Evidence: PMID:17610578 Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. |
| GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | KEEP AS NON CORE | Summary: regulation of mitochondrial membrane per... Reason: Specialized cellular process Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0005515 protein binding | IPI PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endoca... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endocannabinoid signaling. |
| GO:2000124 regulation of endocannabinoid signaling pathway | IMP PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endoca... | KEEP AS NON CORE | Summary: Signaling pathway involvement Reason: Downstream signaling role Supporting Evidence: PMID:23502535 CaMKII regulates diacylglycerol lipase-Ξ± and striatal endocannabinoid signaling. |
| GO:0005954 calcium- and calmodulin-dependent protein kinase complex | ISS GO_REF:0000024 | ACCEPT | Summary: Core kinase function Reason: Defines essential CaMKII catalytic activity |
| GO:0043197 dendritic spine | ISS GO_REF:0000024 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:0060996 dendritic spine development | ISS GO_REF:0000024 | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role |
| GO:2001222 regulation of neuron migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Synaptic/neuronal function Reason: Important tissue-specific function |
| GO:0005739 mitochondrion | IDA PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | KEEP AS NON CORE | Summary: mitochondrion Reason: Specialized cellular process Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0004683 calcium/calmodulin-dependent protein kinase activity | IDA PMID:15994560 Variable control of Ets-1 DNA binding by multiple phosphates... | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: PMID:15994560 Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. |
| GO:0005516 calmodulin binding | IDA PMID:15994560 Variable control of Ets-1 DNA binding by multiple phosphates... | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: PMID:15994560 Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. |
| GO:0005515 protein binding | IPI PMID:25297099 The schizophrenia susceptibility gene dysbindin regulates de... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:25297099 The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. |
| GO:0048813 dendrite morphogenesis | IMP PMID:25297099 The schizophrenia susceptibility gene dysbindin regulates de... | ACCEPT | Summary: Core neuronal localization/function Reason: Essential for CaMKIIΞ± neuronal role Supporting Evidence: PMID:25297099 The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. |
| GO:0014069 postsynaptic density | IDA PMID:17114649 Qualitative and quantitative analyses of protein phosphoryla... | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function Supporting Evidence: PMID:17114649 Epub 2006 Nov 17. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. |
| GO:0002931 response to ischemia | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | UNDECIDED | Summary: The cited heart study supports CaMKII inhibitor/activity effects but does not clearly distinguish Camk2a/CaMKIIalpha-specific biology. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | UNDECIDED | Summary: The cited heart study supports CaMKII activity broadly but does not clearly establish Camk2a/CaMKIIalpha-specific kinase activity. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0010666 positive regulation of cardiac muscle cell apoptotic process | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | UNDECIDED | Summary: Cardiac apoptosis effects are from a broad CaMKII heart context and are not clearly Camk2a/CaMKIIalpha-specific. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0018105 peptidyl-serine phosphorylation | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | UNDECIDED | Summary: The cited heart study supports CaMKII activity broadly but does not clearly establish Camk2a/CaMKIIalpha-specific serine phosphorylation. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0051928 positive regulation of calcium ion transport | IMP PMID:23051746 CaMKII determines mitochondrial stress responses in heart. | UNDECIDED | Summary: Calcium transport effects are from a broad CaMKII heart context and are not clearly Camk2a/CaMKIIalpha-specific. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:23051746 CaMKII determines mitochondrial stress responses in heart. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:18480293 Phosphorylation of Homer3 by calcium/calmodulin-dependent ki... | ACCEPT | Summary: Core kinase function Reason: Essential CaMKII activity Supporting Evidence: PMID:18480293 Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. |
| GO:0005515 protein binding | IPI PMID:15140879 Regulation of the multifunctional Ca2+/calmodulin-dependent ... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:15140879 2004 Mar 31. Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts. |
| GO:0035254 glutamate receptor binding | IPI PMID:16710293 NR2B tyrosine phosphorylation modulates fear learning as wel... | ACCEPT | Summary: GluN2B/NMDA receptor binding is a central non-catalytic synaptic scaffolding interaction for CaMKIIalpha. Reason: Core non-catalytic CaMKIIalpha synaptic function Supporting Evidence: PMID:16710293 May 18. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. PMID:22234183 CaMKII binding to GluN2B is critical during memory consolidation. file:mouse/Camk2a/Camk2a-deep-research-falcon.md Falcon synthesis identifies GluN2B/NMDAR binding as a central CaMKIIalpha structural and scaffolding function. |
| GO:0005515 protein binding | IPI PMID:12223541 The cyclin-dependent kinase 5 activators p35 and p39 interac... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general and uninformative Supporting Evidence: PMID:12223541 The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. |
| GO:0000082 G1/S transition of mitotic cell cycle | IMP PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ A... | UNDECIDED | Summary: The cited vascular smooth muscle study supports CaMKII activity broadly but does not clearly establish Camk2a/CaMKIIalpha-specific cell-cycle biology. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ A... | UNDECIDED | Summary: The cited vascular smooth muscle study supports CaMKII activity broadly but does not clearly establish Camk2a/CaMKIIalpha-specific kinase activity. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. |
| GO:0006816 calcium ion transport | IMP PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ A... | UNDECIDED | Summary: The cited vascular smooth muscle study is not clear evidence for a Camk2a-specific calcium transport annotation. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. |
| GO:0046777 protein autophosphorylation | IMP PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ A... | UNDECIDED | Summary: The cited vascular smooth muscle study supports CaMKII activity broadly but does not clearly establish Camk2a/CaMKIIalpha-specific autophosphorylation. Reason: Evidence is not clearly Camk2a-specific Supporting Evidence: PMID:12660151 Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. |
| GO:0046928 regulation of neurotransmitter secretion | IMP PMID:12629219 Essential function of alpha-calcium/calmodulin-dependent pro... | ACCEPT | Summary: Synaptic/neuronal function Reason: Essential for CaMKII function Supporting Evidence: PMID:12629219 Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. |
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Download this section (compressed HTML)Q: GO obsoleted GO:0099148 regulation of synaptic vesicle docking together with GO:0106020/GO:0106021/GO:0106022 (regulation of vesicle docking), leaving no live term for a protein that changes the number of docked vesicles without itself having GO:0160321 vesicle docking activity. PMID:17660813 reports that alphaCaMKII regulates the number of docked vesicles through a nonenzymatic role. Should this be represented as a regulator of GO:0160321 activity (for example a GO-CAM causal link to the docking-activity annoton of a partner protein, or a new MF regulator term), rather than only through GO:0048172 regulation of short-term neuronal synaptic plasticity?
Suggested experts: SynGO curators, Presynaptic physiologists
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