Cbl

UniProt ID: P22682
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Cbl

Existing Annotations Review

GO Term Evidence Action Reason
GO:0061630 ubiquitin protein ligase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045121 membrane raft
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030971 receptor tyrosine kinase binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001784 phosphotyrosine residue binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005509 calcium ion binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005929 cilium
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008270 zinc ion binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016740 transferase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0023051 regulation of signaling
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046872 metal ion binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902531 regulation of intracellular signal transduction
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12559036
CD2AP/CMS regulates endosome morphology and traffic to the d... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12559036
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
GO:0005515 protein binding
IPI
PMID:23374343
Induction of Siglec-G by RNA viruses inhibits the innate imm... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23374343
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.
GO:0005515 protein binding
IPI
PMID:23799367
Threshold-controlled ubiquitination of the EGFR directs rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23799367
Threshold-controlled ubiquitination of the EGFR directs receptor fate.
GO:0005515 protein binding
IPI
PMID:24440350
Targeting of the MET receptor tyrosine kinase by small molec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24440350
2014 Jan 17. Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation.
GO:0005515 protein binding
IPI
PMID:27474268
Co-recruitment analysis of the CBL and CBLB signalosomes in ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:27474268
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
GO:0005515 protein binding
IPI
PMID:7657591
Tyrosine phosphorylation of the c-cbl proto-oncogene protein... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7657591
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
GO:0005515 protein binding
IPI
PMID:9890970
Fyn associates with Cbl and phosphorylates tyrosine 731 in C... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9890970
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
GO:0000209 protein polyubiquitination
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006513 protein monoubiquitination
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006974 DNA damage response
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008584 male gonad development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010332 response to gamma radiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014823 response to activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017124 SH3 domain binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030424 axon
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030426 growth cone
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033574 response to testosterone
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036120 cellular response to platelet-derived growth factor stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042594 response to starvation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043303 mast cell degranulation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045471 response to ethanol
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048260 positive regulation of receptor-mediated endocytosis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050821 protein stabilization
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051865 protein autoubiquitination
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070534 protein K63-linked ubiquitination
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071456 cellular response to hypoxia
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990090 cellular response to nerve growth factor stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990782 protein tyrosine kinase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005929 cilium
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017124 SH3 domain binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048260 positive regulation of receptor-mediated endocytosis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050821 protein stabilization
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070534 protein K63-linked ubiquitination
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097229 sperm end piece
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000209 protein polyubiquitination
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005925 focal adhesion
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006513 protein monoubiquitination
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017124 SH3 domain binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030424 axon
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030426 growth cone
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051865 protein autoubiquitination
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990782 protein tyrosine kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
TAS
Reactome:R-MMU-9763892 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050821 protein stabilization
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070534 protein K63-linked ubiquitination
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IMP
PMID:12754251
Cbl-mediated ubiquitinylation is required for lysosomal sort... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12754251
2003 May 18. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
GO:0061630 ubiquitin protein ligase activity
IMP
PMID:15962011
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15962011
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
GO:0005886 plasma membrane
IDA
PMID:15383614
c-Cbl directs EGF receptors into an endocytic pathway that i... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15383614
Sep 21. c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.
GO:0016567 protein ubiquitination
ISO
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IGI
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
GO:0061630 ubiquitin protein ligase activity
IGI
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
GO:0061630 ubiquitin protein ligase activity
IMP
PMID:12754251
Cbl-mediated ubiquitinylation is required for lysosomal sort... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12754251
2003 May 18. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
GO:0070086 ubiquitin-dependent endocytosis
ISO
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
GO:0006511 ubiquitin-dependent protein catabolic process
IMP
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0016567 protein ubiquitination
IDA
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IDA
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
IMP
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0061630 ubiquitin protein ligase activity
IDA
PMID:15383614
c-Cbl directs EGF receptors into an endocytic pathway that i... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15383614
Sep 21. c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.
GO:0061630 ubiquitin protein ligase activity
IDA
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0061630 ubiquitin protein ligase activity
IMP
PMID:23457600
Berberine inhibits proliferation and down-regulates epiderma... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
GO:0070086 ubiquitin-dependent endocytosis
IMP
PMID:15383614
c-Cbl directs EGF receptors into an endocytic pathway that i... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15383614
Sep 21. c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.
GO:0016600 flotillin complex
IDA
PMID:11001060
CAP defines a second signalling pathway required for insulin... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11001060
CAP defines a second signalling pathway required for insulin-stimulated glucose transport.
GO:0005515 protein binding
IPI
PMID:9447983
A novel, multifuntional c-Cbl binding protein in insulin rec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9447983
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
GO:0005829 cytosol
TAS
Reactome:R-MMU-9680646 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9680706 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9682158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9682182 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9763891 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9763892 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-9817994 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032487 regulation of Rap protein signal transduction
IMP
PMID:12671687
Negative regulation of Rap1 activation by the Cbl E3 ubiquit... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12671687
Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.
GO:0005794 Golgi apparatus
IDA
PMID:29237719
IFT20 modulates ciliary PDGFRα signaling by regulating the s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29237719
Dec 13. IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
GO:0005929 cilium
IDA
PMID:29237719
IFT20 modulates ciliary PDGFRα signaling by regulating the s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29237719
Dec 13. IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway
IMP
PMID:29237719
IFT20 modulates ciliary PDGFRα signaling by regulating the s... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:29237719
Dec 13. IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
GO:0005515 protein binding
IPI
PMID:8551236
Association of tyrosine protein kinase Zap-70 with the proto... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8551236
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
GO:0005515 protein binding
IPI
PMID:21830225
SH3KBP1-binding protein 1 prevents epidermal growth factor r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21830225
Aug 9. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.
GO:0006511 ubiquitin-dependent protein catabolic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048260 positive regulation of receptor-mediated endocytosis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:11152963
SETA is a multifunctional adapter protein with three SH3 dom... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11152963
SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
GO:0005515 protein binding
IPI
PMID:16455755
Spatial and temporal regulation of GLUT4 translocation by fl... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16455755
Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
GO:0046875 ephrin receptor binding
IPI
PMID:18034775
Ligand binding induces Cbl-dependent EphB1 receptor degradat... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18034775
2007 Dec 19. Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
GO:0006468 protein phosphorylation
ISS
GO_REF:0000024 		REMOVE
Summary: MISANNOTATION: Cbl (E3 ubiquitin-protein ligase CBL) does NOT catalyze phosphorylation. Cbl's enzymatic activity is EC 2.3.2.27 (ubiquitin transferase) - it mediates ubiquitination of receptor tyrosine kinases and other signaling proteins. UniProt explicitly states Cbl is "Phosphorylated on tyrosine residues by" multiple kinases (ALK, EGFR, FGR, INSR, SYK, FYN, ZAP70) - Cbl is the SUBSTRATE of phosphorylation, not the enzyme. The ISS transfer is inappropriate because Cbl has no kinase activity in any species. Cbl should be annotated to ubiquitination processes (GO:0016567), not phosphorylation.
GO:0045453 bone resorption
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017124 SH3 domain binding
IPI
PMID:9447983
A novel, multifuntional c-Cbl binding protein in insulin rec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9447983
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:11001060
CAP defines a second signalling pathway required for insulin-stimulated glucose transport.
PMID:11152963
SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
PMID:12559036
CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
PMID:12671687
Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.
PMID:12754251
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.
PMID:15383614
c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.
PMID:15962011
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
PMID:16455755
Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.
PMID:18034775
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
PMID:21830225
SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.
PMID:23374343
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.
PMID:23457600
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.
PMID:23799367
Threshold-controlled ubiquitination of the EGFR directs receptor fate.
PMID:24440350
Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation.
PMID:27474268
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
PMID:29237719
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
PMID:7657591
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
PMID:8551236
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
PMID:9447983
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
PMID:9890970
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Reactome:R-MMU-9680646
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated
Reactome:R-MMU-9680706
Csf1r trans-autophosphorylates on multiple tyrosine residues
Reactome:R-MMU-9682158
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
Reactome:R-MMU-9682182
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
Reactome:R-MMU-9763891
Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl
Reactome:R-MMU-9763892
p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
Reactome:R-MMU-9817994
Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

📄 View Raw YAML

 
id: P22682
gene_symbol: Cbl
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Cbl'
existing_annotations:
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045121
      label: membrane raft
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030971
      label: receptor tyrosine kinase binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001784
      label: phosphotyrosine residue binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004842
      label: ubiquitin-protein transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005929
      label: cilium
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008270
      label: zinc ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016740
      label: transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0023051
      label: regulation of signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902531
      label: regulation of intracellular signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000583
      label: regulation of platelet-derived growth factor receptor-alpha 
        signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12559036
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12559036
          supporting_text: CD2AP/CMS regulates endosome morphology and traffic 
            to the degradative pathway through its interaction with Rab4 and 
            c-Cbl.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23374343
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23374343
          supporting_text: Induction of Siglec-G by RNA viruses inhibits the 
            innate immune response by promoting RIG-I degradation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23799367
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23799367
          supporting_text: Threshold-controlled ubiquitination of the EGFR 
            directs receptor fate.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24440350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24440350
          supporting_text: 2014 Jan 17. Targeting of the MET receptor tyrosine 
            kinase by small molecule inhibitors leads to MET accumulation by 
            impairing the receptor downregulation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27474268
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27474268
          supporting_text: Co-recruitment analysis of the CBL and CBLB 
            signalosomes in primary T cells identifies CD5 as a key regulator of
            TCR-induced ubiquitylation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:7657591
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7657591
          supporting_text: Tyrosine phosphorylation of the c-cbl proto-oncogene 
            protein product and association with epidermal growth factor (EGF) 
            receptor upon EGF stimulation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9890970
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9890970
          supporting_text: Fyn associates with Cbl and phosphorylates tyrosine 
            731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
  - term:
      id: GO:0000209
      label: protein polyubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005925
      label: focal adhesion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006511
      label: ubiquitin-dependent protein catabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006513
      label: protein monoubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006974
      label: DNA damage response
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008584
      label: male gonad development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010332
      label: response to gamma radiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014823
      label: response to activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016567
      label: protein ubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017124
      label: SH3 domain binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030424
      label: axon
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030426
      label: growth cone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033574
      label: response to testosterone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036120
      label: cellular response to platelet-derived growth factor stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036312
      label: phosphatidylinositol 3-kinase regulatory subunit binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042594
      label: response to starvation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043303
      label: mast cell degranulation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045471
      label: response to ethanol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046875
      label: ephrin receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048260
      label: positive regulation of receptor-mediated endocytosis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050821
      label: protein stabilization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050860
      label: negative regulation of T cell receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050868
      label: negative regulation of T cell activation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051865
      label: protein autoubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070534
      label: protein K63-linked ubiquitination
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071456
      label: cellular response to hypoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990090
      label: cellular response to nerve growth factor stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990782
      label: protein tyrosine kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005929
      label: cilium
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006511
      label: ubiquitin-dependent protein catabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016567
      label: protein ubiquitination
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017124
      label: SH3 domain binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046875
      label: ephrin receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048260
      label: positive regulation of receptor-mediated endocytosis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050821
      label: protein stabilization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050860
      label: negative regulation of T cell receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050868
      label: negative regulation of T cell activation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070534
      label: protein K63-linked ubiquitination
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097229
      label: sperm end piece
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000209
      label: protein polyubiquitination
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005925
      label: focal adhesion
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006513
      label: protein monoubiquitination
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017124
      label: SH3 domain binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030424
      label: axon
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030426
      label: growth cone
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036312
      label: phosphatidylinositol 3-kinase regulatory subunit binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051865
      label: protein autoubiquitination
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990782
      label: protein tyrosine kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9763892
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050821
      label: protein stabilization
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050860
      label: negative regulation of T cell receptor signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050868
      label: negative regulation of T cell activation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070534
      label: protein K63-linked ubiquitination
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IMP
    original_reference_id: PMID:12754251
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12754251
          supporting_text: 2003 May 18. Cbl-mediated ubiquitinylation is 
            required for lysosomal sorting of epidermal growth factor receptor 
            but is dispensable for endocytosis.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IMP
    original_reference_id: PMID:15962011
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15962011
          supporting_text: Sprouty2 acts at the Cbl/CIN85 interface to inhibit 
            epidermal growth factor receptor downregulation.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:15383614
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15383614
          supporting_text: Sep 21. c-Cbl directs EGF receptors into an endocytic
            pathway that involves the ubiquitin-interacting motif of Eps15.
  - term:
      id: GO:0016567
      label: protein ubiquitination
    evidence_type: ISO
    original_reference_id: PMID:11823423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823423
          supporting_text: A mutant EGF-receptor defective in ubiquitylation and
            endocytosis unveils a role for Grb2 in negative signaling.
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IGI
    original_reference_id: PMID:11823423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823423
          supporting_text: A mutant EGF-receptor defective in ubiquitylation and
            endocytosis unveils a role for Grb2 in negative signaling.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IGI
    original_reference_id: PMID:11823423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823423
          supporting_text: A mutant EGF-receptor defective in ubiquitylation and
            endocytosis unveils a role for Grb2 in negative signaling.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IMP
    original_reference_id: PMID:12754251
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12754251
          supporting_text: 2003 May 18. Cbl-mediated ubiquitinylation is 
            required for lysosomal sorting of epidermal growth factor receptor 
            but is dispensable for endocytosis.
  - term:
      id: GO:0070086
      label: ubiquitin-dependent endocytosis
    evidence_type: ISO
    original_reference_id: PMID:11823423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823423
          supporting_text: A mutant EGF-receptor defective in ubiquitylation and
            endocytosis unveils a role for Grb2 in negative signaling.
  - term:
      id: GO:0006511
      label: ubiquitin-dependent protein catabolic process
    evidence_type: IMP
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0016567
      label: protein ubiquitination
    evidence_type: IDA
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IDA
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: IMP
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IDA
    original_reference_id: PMID:15383614
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15383614
          supporting_text: Sep 21. c-Cbl directs EGF receptors into an endocytic
            pathway that involves the ubiquitin-interacting motif of Eps15.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IDA
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IMP
    original_reference_id: PMID:23457600
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23457600
          supporting_text: Berberine inhibits proliferation and down-regulates 
            epidermal growth factor receptor through activation of Cbl in colon 
            tumor cells.
  - term:
      id: GO:0070086
      label: ubiquitin-dependent endocytosis
    evidence_type: IMP
    original_reference_id: PMID:15383614
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15383614
          supporting_text: Sep 21. c-Cbl directs EGF receptors into an endocytic
            pathway that involves the ubiquitin-interacting motif of Eps15.
  - term:
      id: GO:0016600
      label: flotillin complex
    evidence_type: IDA
    original_reference_id: PMID:11001060
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11001060
          supporting_text: CAP defines a second signalling pathway required for 
            insulin-stimulated glucose transport.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9447983
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9447983
          supporting_text: A novel, multifuntional c-Cbl binding protein in 
            insulin receptor signaling in 3T3-L1 adipocytes.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9680646
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9680706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9682158
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9682182
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9763891
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9763892
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9817994
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016567
      label: protein ubiquitination
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032487
      label: regulation of Rap protein signal transduction
    evidence_type: IMP
    original_reference_id: PMID:12671687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12671687
          supporting_text: Negative regulation of Rap1 activation by the Cbl E3 
            ubiquitin ligase.
  - term:
      id: GO:0005794
      label: Golgi apparatus
    evidence_type: IDA
    original_reference_id: PMID:29237719
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29237719
          supporting_text: Dec 13. IFT20 modulates ciliary PDGFRα signaling by 
            regulating the stability of Cbl E3 ubiquitin ligases.
  - term:
      id: GO:0005929
      label: cilium
    evidence_type: IDA
    original_reference_id: PMID:29237719
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29237719
          supporting_text: Dec 13. IFT20 modulates ciliary PDGFRα signaling by 
            regulating the stability of Cbl E3 ubiquitin ligases.
  - term:
      id: GO:2000583
      label: regulation of platelet-derived growth factor receptor-alpha 
        signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:29237719
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:29237719
          supporting_text: Dec 13. IFT20 modulates ciliary PDGFRα signaling by 
            regulating the stability of Cbl E3 ubiquitin ligases.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8551236
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8551236
          supporting_text: Association of tyrosine protein kinase Zap-70 with 
            the protooncogene product p120c-cbl in T lymphocytes.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21830225
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21830225
          supporting_text: Aug 9. SH3KBP1-binding protein 1 prevents epidermal 
            growth factor receptor degradation by the interruption of 
            c-Cbl-CIN85 complex.
  - term:
      id: GO:0006511
      label: ubiquitin-dependent protein catabolic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042059
      label: negative regulation of epidermal growth factor receptor signaling 
        pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048260
      label: positive regulation of receptor-mediated endocytosis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11152963
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11152963
          supporting_text: SETA is a multifunctional adapter protein with three 
            SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16455755
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16455755
          supporting_text: Spatial and temporal regulation of GLUT4 
            translocation by flotillin-1 and caveolin-3 in skeletal muscle 
            cells.
  - term:
      id: GO:0046875
      label: ephrin receptor binding
    evidence_type: IPI
    original_reference_id: PMID:18034775
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18034775
          supporting_text: 2007 Dec 19. Ligand binding induces Cbl-dependent 
            EphB1 receptor degradation through the lysosomal pathway.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        MISANNOTATION: Cbl (E3 ubiquitin-protein ligase CBL) does NOT catalyze phosphorylation.
        Cbl's enzymatic activity is EC 2.3.2.27 (ubiquitin transferase) - it mediates
        ubiquitination of receptor tyrosine kinases and other signaling proteins.
        UniProt
        explicitly states Cbl is "Phosphorylated on tyrosine residues by" multiple
        kinases
        (ALK, EGFR, FGR, INSR, SYK, FYN, ZAP70) - Cbl is the SUBSTRATE of phosphorylation,
        not
        the enzyme. The ISS transfer is inappropriate because Cbl has no kinase activity
        in
        any species. Cbl should be annotated to ubiquitination processes (GO:0016567),
        not phosphorylation.
      action: REMOVE
  - term:
      id: GO:0045453
      label: bone resorption
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017124
      label: SH3 domain binding
    evidence_type: IPI
    original_reference_id: PMID:9447983
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9447983
          supporting_text: A novel, multifuntional c-Cbl binding protein in 
            insulin receptor signaling in 3T3-L1 adipocytes.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:11001060
    title: CAP defines a second signalling pathway required for 
      insulin-stimulated glucose transport.
    findings: []
  - id: PMID:11152963
    title: SETA is a multifunctional adapter protein with three SH3 domains that
      binds Grb2, Cbl, and the novel SB1 proteins.
    findings: []
  - id: PMID:11823423
    title: A mutant EGF-receptor defective in ubiquitylation and endocytosis 
      unveils a role for Grb2 in negative signaling.
    findings: []
  - id: PMID:12559036
    title: CD2AP/CMS regulates endosome morphology and traffic to the 
      degradative pathway through its interaction with Rab4 and c-Cbl.
    findings: []
  - id: PMID:12671687
    title: Negative regulation of Rap1 activation by the Cbl E3 ubiquitin 
      ligase.
    findings: []
  - id: PMID:12754251
    title: Cbl-mediated ubiquitinylation is required for lysosomal sorting of 
      epidermal growth factor receptor but is dispensable for endocytosis.
    findings: []
  - id: PMID:15383614
    title: c-Cbl directs EGF receptors into an endocytic pathway that involves 
      the ubiquitin-interacting motif of Eps15.
    findings: []
  - id: PMID:15962011
    title: Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth 
      factor receptor downregulation.
    findings: []
  - id: PMID:16455755
    title: Spatial and temporal regulation of GLUT4 translocation by flotillin-1
      and caveolin-3 in skeletal muscle cells.
    findings: []
  - id: PMID:18034775
    title: Ligand binding induces Cbl-dependent EphB1 receptor degradation 
      through the lysosomal pathway.
    findings: []
  - id: PMID:21830225
    title: SH3KBP1-binding protein 1 prevents epidermal growth factor receptor 
      degradation by the interruption of c-Cbl-CIN85 complex.
    findings: []
  - id: PMID:23374343
    title: Induction of Siglec-G by RNA viruses inhibits the innate immune 
      response by promoting RIG-I degradation.
    findings: []
  - id: PMID:23457600
    title: Berberine inhibits proliferation and down-regulates epidermal growth 
      factor receptor through activation of Cbl in colon tumor cells.
    findings: []
  - id: PMID:23799367
    title: Threshold-controlled ubiquitination of the EGFR directs receptor 
      fate.
    findings: []
  - id: PMID:24440350
    title: Targeting of the MET receptor tyrosine kinase by small molecule 
      inhibitors leads to MET accumulation by impairing the receptor 
      downregulation.
    findings: []
  - id: PMID:27474268
    title: Co-recruitment analysis of the CBL and CBLB signalosomes in primary T
      cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
    findings: []
  - id: PMID:29237719
    title: IFT20 modulates ciliary PDGFRα signaling by regulating the stability 
      of Cbl E3 ubiquitin ligases.
    findings: []
  - id: PMID:7657591
    title: Tyrosine phosphorylation of the c-cbl proto-oncogene protein product 
      and association with epidermal growth factor (EGF) receptor upon EGF 
      stimulation.
    findings: []
  - id: PMID:8551236
    title: Association of tyrosine protein kinase Zap-70 with the protooncogene 
      product p120c-cbl in T lymphocytes.
    findings: []
  - id: PMID:9447983
    title: A novel, multifuntional c-Cbl binding protein in insulin receptor 
      signaling in 3T3-L1 adipocytes.
    findings: []
  - id: PMID:9890970
    title: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a 
      binding site for phosphatidylinositol 3-kinase.
    findings: []
  - id: Reactome:R-MMU-9680646
    title: Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), 
      Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d 
      (SHIP1), Inppl1 (SHIP2)  bind p-8Y-Csf1r and are activated
    findings: []
  - id: Reactome:R-MMU-9680706
    title: Csf1r trans-autophosphorylates on multiple tyrosine residues
    findings: []
  - id: Reactome:R-MMU-9682158
    title: Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding 
      choline phosphate and 1,2-diacylglycerol
    findings: []
  - id: Reactome:R-MMU-9682182
    title: Csf1r-associated PI3K phosphorylates phosphatidylinositol 
      4,5-bisphosphate
    findings: []
  - id: Reactome:R-MMU-9763891
    title: Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r 
      dimer:Cbl
    findings: []
  - id: Reactome:R-MMU-9763892
    title: p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
    findings: []
  - id: Reactome:R-MMU-9817994
    title: Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
    findings: []