Ccnb1

UniProt ID: P24860
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Ccnb1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0000082 G1/S transition of mitotic cell cycle
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005815 microtubule organizing center
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005759 mitochondrial matrix
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097125 cyclin B1-CDK1 complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007080 mitotic metaphase chromosome alignment
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005813 centrosome
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044772 mitotic cell cycle phase transition
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051301 cell division
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000922 spindle pole
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000940 outer kinetochore
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001556 oocyte maturation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005113 patched binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005759 mitochondrial matrix
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007052 mitotic spindle organization
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007080 mitotic metaphase chromosome alignment
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007283 spermatogenesis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009410 response to xenobiotic stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009612 response to mechanical stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009636 response to toxic substance
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010629 negative regulation of gene expression
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031442 positive regulation of mRNA 3'-end processing
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042246 tissue regeneration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044389 ubiquitin-like protein ligase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045931 positive regulation of mitotic cell cycle
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046680 response to DDT
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048565 digestive tract development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0055015 ventricular cardiac muscle cell development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060045 positive regulation of cardiac muscle cell proliferation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060623 regulation of chromosome condensation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0065003 protein-containing complex assembly
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071283 cellular response to iron(III) ion
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071398 cellular response to fatty acid
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071456 cellular response to hypoxia
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097125 cyclin B1-CDK1 complex
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001933 negative regulation of protein phosphorylation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045860 positive regulation of protein kinase activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000922 spindle pole
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000940 outer kinetochore
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001556 oocyte maturation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005113 patched binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005759 mitochondrial matrix
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005813 centrosome
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007052 mitotic spindle organization
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007080 mitotic metaphase chromosome alignment
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010629 negative regulation of gene expression
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031442 positive regulation of mRNA 3'-end processing
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044389 ubiquitin-like protein ligase binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045931 positive regulation of mitotic cell cycle
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060045 positive regulation of cardiac muscle cell proliferation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060623 regulation of chromosome condensation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0065003 protein-containing complex assembly
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097125 cyclin B1-CDK1 complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12124778
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12124778
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
GO:0005759 mitochondrial matrix
IDA
PMID:24746669
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cel... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24746669
2014 Apr 17. Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
GO:0005634 nucleus
IDA
PMID:17325031
Loss of Cdc20 causes a securin-dependent metaphase arrest in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17325031
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.
GO:0005737 cytoplasm
IDA
PMID:17325031
Loss of Cdc20 causes a securin-dependent metaphase arrest in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17325031
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.
GO:0045787 positive regulation of cell cycle
IDA
PMID:22053081
Upregulation of Cyclin B1 by miRNA and its implications in c... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22053081
Nov 3. Upregulation of Cyclin B1 by miRNA and its implications in cancer.
GO:0048146 positive regulation of fibroblast proliferation
IMP
PMID:22053081
Upregulation of Cyclin B1 by miRNA and its implications in c... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22053081
Nov 3. Upregulation of Cyclin B1 by miRNA and its implications in cancer.
GO:0016020 membrane
IDA
PMID:9539739
Cyclin B2-null mice develop normally and are fertile whereas... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9539739
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
GO:0005813 centrosome
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:19376971
Role of Filia, a maternal effect gene, in maintaining euploi... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19376971
Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
GO:0005634 nucleus
IDA
PMID:16489008
Patched1 functions as a gatekeeper by promoting cell cycle p... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16489008
Patched1 functions as a gatekeeper by promoting cell cycle progression.
GO:0001701 in utero embryonic development
IMP
PMID:9539739
Cyclin B2-null mice develop normally and are fertile whereas... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9539739
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
GO:0005634 nucleus
ISO
PMID:16109376
The bromodomain protein Brd4 is a positive regulatory compon... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16109376
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
GO:0005634 nucleus
IDA
PMID:14993286
Cyclin F disruption compromises placental development and af... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14993286
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
GO:0006468 protein phosphorylation
IDA
PMID:12124778
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with... 		MODIFY
Summary: OVER-ANNOTATION: Cyclin B1 does NOT catalyze phosphorylation itself - it activates CDK1 (Cdc2) which performs the catalytic phosphorylation. PMID:12124778 studies the "Cdk1/CyclinB1 kinase complex" where the kinase activity belongs to CDK1. UniProt confirms: "Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex...The cyclin subunit imparts substrate specificity to the complex." The correct annotation should be to kinase activator activity (GO:0061575, already annotated via IEA) rather than the phosphorylation process.
Supporting Evidence:
PMID:12124778
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
GO:0005515 protein binding
IPI
PMID:12525704
RFPL4 interacts with oocyte proteins of the ubiquitin-protea... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12525704
RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:12124778
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
PMID:12525704
RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.
PMID:14993286
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
PMID:16109376
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
PMID:16489008
Patched1 functions as a gatekeeper by promoting cell cycle progression.
PMID:17325031
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.
PMID:19376971
Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.
PMID:22053081
Upregulation of Cyclin B1 by miRNA and its implications in cancer.
PMID:24746669
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
PMID:9539739
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.

📄 View Raw YAML

 
id: P24860
gene_symbol: Ccnb1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ccnb1'
existing_annotations:
  - term:
      id: GO:0000082
      label: G1/S transition of mitotic cell cycle
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005815
      label: microtubule organizing center
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005759
      label: mitochondrial matrix
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097125
      label: cyclin B1-CDK1 complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007080
      label: mitotic metaphase chromosome alignment
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044772
      label: mitotic cell cycle phase transition
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051301
      label: cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000922
      label: spindle pole
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000940
      label: outer kinetochore
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001556
      label: oocyte maturation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005113
      label: patched binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005759
      label: mitochondrial matrix
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007052
      label: mitotic spindle organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007080
      label: mitotic metaphase chromosome alignment
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007283
      label: spermatogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009410
      label: response to xenobiotic stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009612
      label: response to mechanical stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009636
      label: response to toxic substance
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010971
      label: positive regulation of G2/M transition of mitotic cell cycle
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031442
      label: positive regulation of mRNA 3'-end processing
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042246
      label: tissue regeneration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044389
      label: ubiquitin-like protein ligase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045931
      label: positive regulation of mitotic cell cycle
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046680
      label: response to DDT
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048565
      label: digestive tract development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051987
      label: positive regulation of attachment of spindle microtubules to 
        kinetochore
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0055015
      label: ventricular cardiac muscle cell development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060045
      label: positive regulation of cardiac muscle cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060623
      label: regulation of chromosome condensation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0065003
      label: protein-containing complex assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071283
      label: cellular response to iron(III) ion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071398
      label: cellular response to fatty acid
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071456
      label: cellular response to hypoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090266
      label: regulation of mitotic cell cycle spindle assembly checkpoint
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097125
      label: cyclin B1-CDK1 complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905448
      label: positive regulation of mitochondrial ATP synthesis coupled electron
        transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001933
      label: negative regulation of protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000922
      label: spindle pole
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000940
      label: outer kinetochore
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001556
      label: oocyte maturation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005113
      label: patched binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005759
      label: mitochondrial matrix
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007052
      label: mitotic spindle organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007080
      label: mitotic metaphase chromosome alignment
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010971
      label: positive regulation of G2/M transition of mitotic cell cycle
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031442
      label: positive regulation of mRNA 3'-end processing
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044389
      label: ubiquitin-like protein ligase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044877
      label: protein-containing complex binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045931
      label: positive regulation of mitotic cell cycle
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051987
      label: positive regulation of attachment of spindle microtubules to 
        kinetochore
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060045
      label: positive regulation of cardiac muscle cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060623
      label: regulation of chromosome condensation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0065003
      label: protein-containing complex assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090266
      label: regulation of mitotic cell cycle spindle assembly checkpoint
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097125
      label: cyclin B1-CDK1 complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905448
      label: positive regulation of mitochondrial ATP synthesis coupled electron
        transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12124778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12124778
          supporting_text: GADD45b and GADD45g are cdc2/cyclinB1 kinase 
            inhibitors with a role in S and G2/M cell cycle checkpoints induced 
            by genotoxic stress.
  - term:
      id: GO:0005759
      label: mitochondrial matrix
    evidence_type: IDA
    original_reference_id: PMID:24746669
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24746669
          supporting_text: 2014 Apr 17. Cyclin B1/Cdk1 coordinates mitochondrial
            respiration for cell-cycle G2/M progression.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:17325031
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17325031
          supporting_text: Loss of Cdc20 causes a securin-dependent metaphase 
            arrest in two-cell mouse embryos.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:17325031
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17325031
          supporting_text: Loss of Cdc20 causes a securin-dependent metaphase 
            arrest in two-cell mouse embryos.
  - term:
      id: GO:0045787
      label: positive regulation of cell cycle
    evidence_type: IDA
    original_reference_id: PMID:22053081
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22053081
          supporting_text: Nov 3. Upregulation of Cyclin B1 by miRNA and its 
            implications in cancer.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IMP
    original_reference_id: PMID:22053081
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22053081
          supporting_text: Nov 3. Upregulation of Cyclin B1 by miRNA and its 
            implications in cancer.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IDA
    original_reference_id: PMID:9539739
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9539739
          supporting_text: Cyclin B2-null mice develop normally and are fertile 
            whereas cyclin B1-null mice die in utero.
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:19376971
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19376971
          supporting_text: Role of Filia, a maternal effect gene, in maintaining
            euploidy during cleavage-stage mouse embryogenesis.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:16489008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16489008
          supporting_text: Patched1 functions as a gatekeeper by promoting cell 
            cycle progression.
  - term:
      id: GO:0001701
      label: in utero embryonic development
    evidence_type: IMP
    original_reference_id: PMID:9539739
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9539739
          supporting_text: Cyclin B2-null mice develop normally and are fertile 
            whereas cyclin B1-null mice die in utero.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: PMID:16109376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:14993286
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14993286
          supporting_text: Cyclin F disruption compromises placental development
            and affects normal cell cycle execution.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:12124778
    review:
      summary: >-
        OVER-ANNOTATION: Cyclin B1 does NOT catalyze phosphorylation itself - it activates
        CDK1 (Cdc2) which performs the catalytic phosphorylation. PMID:12124778 studies
        the
        "Cdk1/CyclinB1 kinase complex" where the kinase activity belongs to CDK1.
        UniProt
        confirms: "Interacts with the CDC2 protein kinase to form a serine/threonine
        kinase
        holoenzyme complex...The cyclin subunit imparts substrate specificity to the
        complex."
        The correct annotation should be to kinase activator activity (GO:0061575,
        already
        annotated via IEA) rather than the phosphorylation process.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:12124778
          supporting_text: GADD45b and GADD45g are cdc2/cyclinB1 kinase 
            inhibitors with a role in S and G2/M cell cycle checkpoints induced 
            by genotoxic stress.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12525704
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12525704
          supporting_text: RFPL4 interacts with oocyte proteins of the 
            ubiquitin-proteasome degradation pathway.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:12124778
    title: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role 
      in S and G2/M cell cycle checkpoints induced by genotoxic stress.
    findings: []
  - id: PMID:12525704
    title: RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome 
      degradation pathway.
    findings: []
  - id: PMID:14993286
    title: Cyclin F disruption compromises placental development and affects 
      normal cell cycle execution.
    findings: []
  - id: PMID:16109376
    title: The bromodomain protein Brd4 is a positive regulatory component of 
      P-TEFb and stimulates RNA polymerase II-dependent transcription.
    findings: []
  - id: PMID:16489008
    title: Patched1 functions as a gatekeeper by promoting cell cycle 
      progression.
    findings: []
  - id: PMID:17325031
    title: Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell
      mouse embryos.
    findings: []
  - id: PMID:19376971
    title: Role of Filia, a maternal effect gene, in maintaining euploidy during
      cleavage-stage mouse embryogenesis.
    findings: []
  - id: PMID:22053081
    title: Upregulation of Cyclin B1 by miRNA and its implications in cancer.
    findings: []
  - id: PMID:24746669
    title: Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle 
      G2/M progression.
    findings: []
  - id: PMID:9539739
    title: Cyclin B2-null mice develop normally and are fertile whereas cyclin 
      B1-null mice die in utero.
    findings: []