Ccne1

id: Q61457
gene_symbol: Ccne1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ccne1'
existing_annotations:
  - term:
      id: GO:0000082
      label: G1/S transition of mitotic cell cycle
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097134
      label: cyclin E1-CDK2 complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005815
      label: microtubule organizing center
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900087
      label: positive regulation of G1/S transition of mitotic cell cycle
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000723
      label: telomere maintenance
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006270
      label: DNA replication initiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007129
      label: homologous chromosome pairing at meiosis
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051301
      label: cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17700700
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17700700
          supporting_text: Cdk1 is sufficient to drive the mammalian cell cycle.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19592082
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19592082
          supporting_text: Jul 9. Cyclin A is redundant in fibroblasts but 
            essential in hematopoietic and embryonic stem cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20150892
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20150892
          supporting_text: Genetic analysis of Ras signalling pathways in cell 
            proliferation, migration and survival.
  - term:
      id: GO:0000082
      label: G1/S transition of mitotic cell cycle
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902462
      label: positive regulation of mesenchymal stem cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000082
      label: G1/S transition of mitotic cell cycle
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044877
      label: protein-containing complex binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045597
      label: positive regulation of cell differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097134
      label: cyclin E1-CDK2 complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902462
      label: positive regulation of mesenchymal stem cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IGI
    original_reference_id: PMID:7797074
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7797074
          supporting_text: Regulation of the retinoblastoma protein-related p107
            by G1 cyclin complexes.
  - term:
      id: GO:0000723
      label: telomere maintenance
    evidence_type: IGI
    original_reference_id: PMID:24586195
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24586195
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0007129
      label: homologous chromosome pairing at meiosis
    evidence_type: IGI
    original_reference_id: PMID:24586195
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24586195
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0032880
      label: regulation of protein localization
    evidence_type: IGI
    original_reference_id: PMID:24586195
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24586195
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0070192
      label: chromosome organization involved in meiotic cell cycle
    evidence_type: IGI
    original_reference_id: PMID:24586195
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24586195
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0097134
      label: cyclin E1-CDK2 complex
    evidence_type: IDA
    original_reference_id: PMID:7739547
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7739547
          supporting_text: Novel INK4 proteins, p19 and p18, are specific 
            inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISS
    original_reference_id: PMID:10500095
    review:
      summary: >-
        OVER-ANNOTATION: Cyclin E1 does NOT catalyze phosphorylation itself - it activates
        CDK2 which performs the catalytic phosphorylation. UniProt states: "Interacts
        with
        CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex.
        The cyclin
        subunit imparts substrate specificity to the complex." PMID:10500095 is about
        cyclin
        E degradation by Cullin-3, not about cyclin E performing phosphorylation.
        The
        correct annotation for cyclin E1 is kinase regulator activity (GO:0016538
        already
        annotated via IDA) rather than the phosphorylation process.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:10500095
          supporting_text: Cullin-3 targets cyclin E for ubiquitination and 
            controls S phase in mammalian cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20215406
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20215406
          supporting_text: Mar 9. Ciz1 cooperates with cyclin-A-CDK2 to activate
            mammalian DNA replication in vitro.
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:11981756
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11981756
          supporting_text: The p21(Cip1) protein, a cyclin inhibitor, regulates 
            the levels and the intracellular localization of CDC25A in mice 
            regenerating livers.
  - term:
      id: GO:0016055
      label: Wnt signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:19056892
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19056892
          supporting_text: A functional link between Wnt signaling and 
            SKP2-independent p27 turnover in mammary tumors.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:10500095
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10500095
          supporting_text: Cullin-3 targets cyclin E for ubiquitination and 
            controls S phase in mammalian cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10500095
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10500095
          supporting_text: Cullin-3 targets cyclin E for ubiquitination and 
            controls S phase in mammalian cells.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: PMID:16109376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IDA
    original_reference_id: PMID:12970171
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12970171
          supporting_text: Deletion of Mnt leads to disrupted cell cycle control
            and tumorigenesis.
  - term:
      id: GO:0051726
      label: regulation of cell cycle
    evidence_type: IDA
    original_reference_id: PMID:12970171
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12970171
          supporting_text: Deletion of Mnt leads to disrupted cell cycle control
            and tumorigenesis.
  - term:
      id: GO:0000307
      label: cyclin-dependent protein kinase holoenzyme complex
    evidence_type: IPI
    original_reference_id: PMID:12970760
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12970760
          supporting_text: 'Caspase-3 regulates cell cycle in B cells: a consequence
            of substrate specificity.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12970760
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12970760
          supporting_text: 'Caspase-3 regulates cell cycle in B cells: a consequence
            of substrate specificity.'
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:12124778
    review:
      summary: >-
        OVER-ANNOTATION: Cyclin E1 does NOT catalyze phosphorylation itself - it activates
        CDK2 which performs the catalytic phosphorylation. PMID:12124778 studies inhibition
        of the "Cdk1/CyclinB1 kinase complex" and "cyclinE/Cdk2 kinase complex" where
        the
        kinase activity belongs to the CDK partner, not to the cyclin. The correct
        annotation
        should be to kinase regulator activity rather than the phosphorylation process.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:12124778
          supporting_text: GADD45b and GADD45g are cdc2/cyclinB1 kinase 
            inhibitors with a role in S and G2/M cell cycle checkpoints induced 
            by genotoxic stress.
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: IDA
    original_reference_id: PMID:12124778
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12124778
          supporting_text: GADD45b and GADD45g are cdc2/cyclinB1 kinase 
            inhibitors with a role in S and G2/M cell cycle checkpoints induced 
            by genotoxic stress.
  - term:
      id: GO:0006270
      label: DNA replication initiation
    evidence_type: IMP
    original_reference_id: PMID:12941272
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12941272
          supporting_text: Cyclin E ablation in the mouse.
references:
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10500095
    title: Cullin-3 targets cyclin E for ubiquitination and controls S phase in 
      mammalian cells.
    findings: []
  - id: PMID:11981756
    title: The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and 
      the intracellular localization of CDC25A in mice regenerating livers.
    findings: []
  - id: PMID:12124778
    title: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role 
      in S and G2/M cell cycle checkpoints induced by genotoxic stress.
    findings: []
  - id: PMID:12941272
    title: Cyclin E ablation in the mouse.
    findings: []
  - id: PMID:12970171
    title: Deletion of Mnt leads to disrupted cell cycle control and 
      tumorigenesis.
    findings: []
  - id: PMID:12970760
    title: 'Caspase-3 regulates cell cycle in B cells: a consequence of substrate
      specificity.'
    findings: []
  - id: PMID:16109376
    title: The bromodomain protein Brd4 is a positive regulatory component of 
      P-TEFb and stimulates RNA polymerase II-dependent transcription.
    findings: []
  - id: PMID:17700700
    title: Cdk1 is sufficient to drive the mammalian cell cycle.
    findings: []
  - id: PMID:19056892
    title: A functional link between Wnt signaling and SKP2-independent p27 
      turnover in mammary tumors.
    findings: []
  - id: PMID:19592082
    title: Cyclin A is redundant in fibroblasts but essential in hematopoietic 
      and embryonic stem cells.
    findings: []
  - id: PMID:20150892
    title: Genetic analysis of Ras signalling pathways in cell proliferation, 
      migration and survival.
    findings: []
  - id: PMID:20215406
    title: Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA 
      replication in vitro.
    findings: []
  - id: PMID:24586195
    title: Mammalian E-type cyclins control chromosome pairing, telomere 
      stability and CDK2 localization in male meiosis.
    findings: []
  - id: PMID:7739547
    title: Novel INK4 proteins, p19 and p18, are specific inhibitors of the 
      cyclin D-dependent kinases CDK4 and CDK6.
    findings: []
  - id: PMID:7797074
    title: Regulation of the retinoblastoma protein-related p107 by G1 cyclin 
      complexes.
    findings: []