Ccnt1

id: Q9QWV9
gene_symbol: Ccnt1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ccnt1'
existing_annotations:
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032786
      label: positive regulation of DNA-templated transcription, elongation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008024
      label: cyclin/CDK positive transcription elongation factor complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006357
      label: regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016538
      label: cyclin-dependent protein serine/threonine kinase regulator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051301
      label: cell division
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20434984
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20434984
          supporting_text: c-Myc regulates transcriptional pause release.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:22922464
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22922464
          supporting_text: Bromodomain-dependent stage-specific male genome 
            programming by Brdt.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008024
      label: cyclin/CDK positive transcription elongation factor complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032968
      label: positive regulation of transcription elongation by RNA polymerase 
        II
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043923
      label: host-mediated activation of viral transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070063
      label: RNA polymerase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070691
      label: P-TEFb complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097322
      label: 7SK snRNA binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140297
      label: DNA-binding transcription factor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140693
      label: molecular condensate scaffold activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008024
      label: cyclin/CDK positive transcription elongation factor complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032968
      label: positive regulation of transcription elongation by RNA polymerase 
        II
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043923
      label: host-mediated activation of viral transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070063
      label: RNA polymerase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070691
      label: P-TEFb complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097322
      label: 7SK snRNA binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140297
      label: DNA-binding transcription factor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140693
      label: molecular condensate scaffold activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032968
      label: positive regulation of transcription elongation by RNA polymerase 
        II
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070691
      label: P-TEFb complex
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0140693
      label: molecular condensate scaffold activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IDA
    original_reference_id: PMID:22547058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22547058
          supporting_text: 2012 Apr 30. Cyclin K-containing kinase complexes 
            maintain self-renewal in murine embryonic stem cells.
  - term:
      id: GO:0097322
      label: 7SK snRNA binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008024
      label: cyclin/CDK positive transcription elongation factor complex
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003682
      label: chromatin binding
    evidence_type: IDA
    original_reference_id: PMID:18662700
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18662700
          supporting_text: 2008 Jul 16. The positive transcription elongation 
            factor b is an essential cofactor for the activation of 
            transcription by myocyte enhancer factor 2.
  - term:
      id: GO:0000976
      label: transcription cis-regulatory region binding
    evidence_type: IDA
    original_reference_id: PMID:20570862
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20570862
          supporting_text: 2010 Jun 22. Multiple functions of Ldb1 required for 
            beta-globin activation during erythroid differentiation.
  - term:
      id: GO:0008024
      label: cyclin/CDK positive transcription elongation factor complex
    evidence_type: TAS
    original_reference_id: PMID:20570862
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20570862
          supporting_text: 2010 Jun 22. Multiple functions of Ldb1 required for 
            beta-globin activation during erythroid differentiation.
  - term:
      id: GO:0003677
      label: DNA binding
    evidence_type: ISO
    original_reference_id: PMID:16109376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:16109376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISO
    original_reference_id: PMID:16109376
    review:
      summary: >-
        OVER-ANNOTATION: Cyclin T1 does NOT catalyze phosphorylation itself - it is
        the
        "regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex"
        (UniProt). UniProt states it is "Required to activate the protein kinase activity
        of CDK9". PMID:16109376 discusses "P-TEFb-dependent phosphorylation of RNA
        polymerase II" where the kinase activity belongs to CDK9, not Cyclin T1. The
        correct annotation should be to kinase activator activity (GO:0061575 already
        annotated via ISS) rather than the phosphorylation process.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
  - term:
      id: GO:0017069
      label: snRNA binding
    evidence_type: IDA
    original_reference_id: PMID:16109376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16109376
          supporting_text: The bromodomain protein Brd4 is a positive regulatory
            component of P-TEFb and stimulates RNA polymerase II-dependent 
            transcription.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:16109376
    title: The bromodomain protein Brd4 is a positive regulatory component of 
      P-TEFb and stimulates RNA polymerase II-dependent transcription.
    findings: []
  - id: PMID:18662700
    title: The positive transcription elongation factor b is an essential 
      cofactor for the activation of transcription by myocyte enhancer factor 2.
    findings: []
  - id: PMID:20434984
    title: c-Myc regulates transcriptional pause release.
    findings: []
  - id: PMID:20570862
    title: Multiple functions of Ldb1 required for beta-globin activation during
      erythroid differentiation.
    findings: []
  - id: PMID:22547058
    title: Cyclin K-containing kinase complexes maintain self-renewal in murine 
      embryonic stem cells.
    findings: []
  - id: PMID:22922464
    title: Bromodomain-dependent stage-specific male genome programming by Brdt.
    findings: []