Cdc42

id: P60766
gene_symbol: Cdc42
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Cdc42'
existing_annotations:
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005525
      label: GTP binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007015
      label: actin filament organization
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030010
      label: establishment of cell polarity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006897
      label: endocytosis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051489
      label: regulation of filopodium assembly
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000166
      label: nucleotide binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003925
      label: G protein activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000003
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005525
      label: GTP binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005819
      label: spindle
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007264
      label: small GTPase-mediated signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007399
      label: nervous system development
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009653
      label: anatomical structure morphogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016787
      label: hydrolase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030496
      label: midbody
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031258
      label: lamellipodium membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051130
      label: positive regulation of cellular component organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071944
      label: cell periphery
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12123608
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12123608
          supporting_text: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to 
            regulate RhoA and growth cone morphology.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15537656
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15537656
          supporting_text: 2004 Nov 9. A direct interaction between Cdc42 and 
            vesicle-associated membrane protein 2 regulates SNARE-dependent 
            insulin exocytosis.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18325335
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18325335
          supporting_text: 2008 Mar 4. Affixin activates Rac1 via betaPIX in 
            C2C12 myoblast.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18541910
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18541910
          supporting_text: Bves directly interacts with GEFT, and controls cell 
            shape and movement through regulation of Rac1/Cdc42 activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18854161
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18854161
          supporting_text: ACF7 regulates cytoskeletal-focal adhesion dynamics 
            and migration and has ATPase activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19893577
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19893577
          supporting_text: The adenomatous polyposis coli-associated exchange 
            factors Asef and Asef2 are required for adenoma formation in 
            Apc(Min/+)mice.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23706742
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23706742
          supporting_text: RAS and RHO families of GTPases directly regulate 
            distinct phosphoinositide 3-kinase isoforms.
  - term:
      id: GO:0006911
      label: phagocytosis, engulfment
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007015
      label: actin filament organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007229
      label: integrin-mediated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010591
      label: regulation of lamellipodium assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010592
      label: positive regulation of lamellipodium assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0015630
      label: microtubule cytoskeleton
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017119
      label: Golgi transport complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030036
      label: actin cytoskeleton organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030175
      label: filopodium
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030307
      label: positive regulation of cell growth
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031274
      label: positive regulation of pseudopodium assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031333
      label: negative regulation of protein-containing complex assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031996
      label: thioesterase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032427
      label: GBD domain binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032467
      label: positive regulation of cytokinesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032956
      label: regulation of actin cytoskeleton organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034191
      label: apolipoprotein A-I receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034329
      label: cell junction assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036464
      label: cytoplasmic ribonucleoprotein granule
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038189
      label: neuropilin signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044788
      label: host-mediated perturbation of viral process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045198
      label: establishment of epithelial cell apical/basal polarity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051233
      label: spindle midzone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051489
      label: regulation of filopodium assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051491
      label: positive regulation of filopodium assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051492
      label: regulation of stress fiber assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051496
      label: positive regulation of stress fiber assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051988
      label: regulation of attachment of spindle microtubules to kinetochore
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072686
      label: mitotic spindle
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900026
      label: positive regulation of substrate adhesion-dependent cell spreading
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0015630
      label: microtubule cytoskeleton
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043085
      label: positive regulation of catalytic activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000139
      label: Golgi membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002040
      label: sprouting angiogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005525
      label: GTP binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005525
      label: GTP binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005813
      label: centrosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006911
      label: phagocytosis, engulfment
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007015
      label: actin filament organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007015
      label: actin filament organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007030
      label: Golgi organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007229
      label: integrin-mediated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010591
      label: regulation of lamellipodium assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010592
      label: positive regulation of lamellipodium assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017119
      label: Golgi transport complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030036
      label: actin cytoskeleton organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030141
      label: secretory granule
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030175
      label: filopodium
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030307
      label: positive regulation of cell growth
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030496
      label: midbody
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031274
      label: positive regulation of pseudopodium assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031333
      label: negative regulation of protein-containing complex assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031435
      label: mitogen-activated protein kinase kinase kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031996
      label: thioesterase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032427
      label: GBD domain binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032467
      label: positive regulation of cytokinesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032956
      label: regulation of actin cytoskeleton organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032991
      label: protein-containing complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034191
      label: apolipoprotein A-I receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034329
      label: cell junction assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036464
      label: cytoplasmic ribonucleoprotein granule
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038189
      label: neuropilin signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043525
      label: positive regulation of neuron apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044788
      label: host-mediated perturbation of viral process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045198
      label: establishment of epithelial cell apical/basal polarity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045740
      label: positive regulation of DNA replication
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046330
      label: positive regulation of JNK cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051233
      label: spindle midzone
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051489
      label: regulation of filopodium assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051491
      label: positive regulation of filopodium assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051492
      label: regulation of stress fiber assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051496
      label: positive regulation of stress fiber assembly
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051683
      label: establishment of Golgi localization
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051835
      label: positive regulation of synapse structural plasticity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051988
      label: regulation of attachment of spindle microtubules to kinetochore
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061630
      label: ubiquitin protein ligase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072384
      label: organelle transport along microtubule
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072686
      label: mitotic spindle
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090135
      label: actin filament branching
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090316
      label: positive regulation of intracellular protein transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0098685
      label: Schaffer collateral - CA1 synapse
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0099159
      label: regulation of modification of postsynaptic structure
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900026
      label: positive regulation of substrate adhesion-dependent cell spreading
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24076653
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24076653
          supporting_text: CDC42 switches IRSp53 from inhibition of actin growth
            to elongation by clustering of VASP.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:37140151
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:37140151
          supporting_text: Biallelic variants in IQCN cause sperm flagellar 
            assembly defects and male infertility.
  - term:
      id: GO:0098794
      label: postsynapse
    evidence_type: IDA
    original_reference_id: PMID:33531495
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33531495
          supporting_text: Photoactivatable CaMKII induces synaptic plasticity 
            in single synapses.
  - term:
      id: GO:0098794
      label: postsynapse
    evidence_type: IMP
    original_reference_id: PMID:33531495
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33531495
          supporting_text: Photoactivatable CaMKII induces synaptic plasticity 
            in single synapses.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IDA
    original_reference_id: PMID:25851601
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25851601
          supporting_text: 2015 Apr 7. The RhoGEF DOCK10 is essential for 
            dendritic spine morphogenesis.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IMP
    original_reference_id: PMID:25851601
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25851601
          supporting_text: 2015 Apr 7. The RhoGEF DOCK10 is essential for 
            dendritic spine morphogenesis.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IDA
    original_reference_id: PMID:33531495
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33531495
          supporting_text: Photoactivatable CaMKII induces synaptic plasticity 
            in single synapses.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IMP
    original_reference_id: PMID:33531495
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:33531495
          supporting_text: Photoactivatable CaMKII induces synaptic plasticity 
            in single synapses.
  - term:
      id: GO:0099175
      label: regulation of postsynapse organization
    evidence_type: IDA
    original_reference_id: PMID:25851601
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25851601
          supporting_text: 2015 Apr 7. The RhoGEF DOCK10 is essential for 
            dendritic spine morphogenesis.
  - term:
      id: GO:0099175
      label: regulation of postsynapse organization
    evidence_type: IMP
    original_reference_id: PMID:25851601
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25851601
          supporting_text: 2015 Apr 7. The RhoGEF DOCK10 is essential for 
            dendritic spine morphogenesis.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0003253
      label: cardiac neural crest cell migration involved in outflow tract 
        morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: >-
        OVER-ANNOTATION: Cdc42 (Cell division control protein 42 homolog) does NOT
        catalyze
        phosphorylation. Cdc42 is a small GTPase with EC 3.6.5.2 (GTPase activity).
        PMID:31219639
        titled "Cdc42 activation by endothelin regulates neural crest cell migration"
        describes
        Cdc42 being ACTIVATED by endothelin signaling - "activation of Cdc42 by endothelin
        signaling is important for CNCC migration". Cdc42 cycles between GTP-bound
        (active)
        and GDP-bound (inactive) states to regulate actin cytoskeleton organization.
        UniProt
        explicitly states Cdc42 has "GTPase activity" - it has NO kinase activity.
        The
        phosphorylation events in this pathway are performed by downstream kinases
        activated
        by Cdc42 signaling, not by Cdc42 itself.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0031252
      label: cell leading edge
    evidence_type: IDA
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15710388
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15710388
          supporting_text: 'Epub 2005 Jan 13. Zizimin2: a novel, DOCK180-related Cdc42
            guanine nucleotide exchange factor expressed predominantly in lymphocytes.'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18604197
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18604197
          supporting_text: IQGAP3 regulates cell proliferation through the 
            Ras/ERK signalling cascade.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:21828338
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21828338
          supporting_text: Cool-1/βPIX functions as a guanine nucleotide 
            exchange factor in the cycling of Cdc42 to regulate insulin 
            secretion.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8464478
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8464478
          supporting_text: Oncogene ect2 is related to regulators of small 
            GTP-binding proteins.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: ISO
    original_reference_id: PMID:27917469
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27917469
          supporting_text: Association of dysfunctional synapse defective 1 
            (SYDE1) with restricted fetal growth - SYDE1 regulates placental 
            cell migration and invasion.
  - term:
      id: GO:0048549
      label: positive regulation of pinocytosis
    evidence_type: IMP
    original_reference_id: PMID:24792215
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24792215
          supporting_text: eCollection 2014. CLN3 deficient cells display 
            defects in the ARF1-Cdc42 pathway and actin-dependent events.
  - term:
      id: GO:0045335
      label: phagocytic vesicle
    evidence_type: IDA
    original_reference_id: PMID:19144319
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19144319
          supporting_text: The phagosomal proteome in interferon-gamma-activated
            macrophages.
  - term:
      id: GO:0071346
      label: cellular response to type II interferon
    evidence_type: IDA
    original_reference_id: PMID:19144319
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19144319
          supporting_text: The phagosomal proteome in interferon-gamma-activated
            macrophages.
  - term:
      id: GO:0006911
      label: phagocytosis, engulfment
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007015
      label: actin filament organization
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034329
      label: cell junction assembly
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045198
      label: establishment of epithelial cell apical/basal polarity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051491
      label: positive regulation of filopodium assembly
    evidence_type: IMP
    original_reference_id: PMID:22494997
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22494997
          supporting_text: Age-related guanine nucleotide exchange factor, mouse
            Zizimin2, induces filopodia in bone marrow-derived dendritic cells.
  - term:
      id: GO:0060997
      label: dendritic spine morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:25851601
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25851601
          supporting_text: 2015 Apr 7. The RhoGEF DOCK10 is essential for 
            dendritic spine morphogenesis.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IDA
    original_reference_id: PMID:18838382
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18838382
          supporting_text: 2008 Oct 6. FGD2, a CDC42-specific exchange factor 
            expressed by antigen-presenting cells, localizes to early endosomes 
            and active membrane ruffles.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IGI
    original_reference_id: PMID:18838382
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18838382
          supporting_text: 2008 Oct 6. FGD2, a CDC42-specific exchange factor 
            expressed by antigen-presenting cells, localizes to early endosomes 
            and active membrane ruffles.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18838382
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18838382
          supporting_text: 2008 Oct 6. FGD2, a CDC42-specific exchange factor 
            expressed by antigen-presenting cells, localizes to early endosomes 
            and active membrane ruffles.
  - term:
      id: GO:0000322
      label: storage vacuole
    evidence_type: IDA
    original_reference_id: PMID:21828338
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21828338
          supporting_text: Cool-1/βPIX functions as a guanine nucleotide 
            exchange factor in the cycling of Cdc42 to regulate insulin 
            secretion.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: PMID:21828338
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21828338
          supporting_text: Cool-1/βPIX functions as a guanine nucleotide 
            exchange factor in the cycling of Cdc42 to regulate insulin 
            secretion.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:21828338
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21828338
          supporting_text: Cool-1/βPIX functions as a guanine nucleotide 
            exchange factor in the cycling of Cdc42 to regulate insulin 
            secretion.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:25217619
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25217619
          supporting_text: Phosphoinositide 3-kinase p85beta regulates 
            invadopodium formation.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-3928643
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-442572
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-448947
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-5665684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006897
      label: endocytosis
    evidence_type: IMP
    original_reference_id: PMID:24792215
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24792215
          supporting_text: eCollection 2014. CLN3 deficient cells display 
            defects in the ARF1-Cdc42 pathway and actin-dependent events.
  - term:
      id: GO:0043209
      label: myelin sheath
    evidence_type: HDA
    original_reference_id: PMID:17634366
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17634366
          supporting_text: Proteolipid protein is required for transport of 
            sirtuin 2 into CNS myelin.
  - term:
      id: GO:0031256
      label: leading edge membrane
    evidence_type: IDA
    original_reference_id: PMID:22461490
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22461490
          supporting_text: 2012 Mar 28. DOCK8 is a Cdc42 activator critical for 
            interstitial dendritic cell migration during immune responses.
  - term:
      id: GO:0036336
      label: dendritic cell migration
    evidence_type: IGI
    original_reference_id: PMID:22461490
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22461490
          supporting_text: 2012 Mar 28. DOCK8 is a Cdc42 activator critical for 
            interstitial dendritic cell migration during immune responses.
  - term:
      id: GO:0005525
      label: GTP binding
    evidence_type: ISO
    original_reference_id: PMID:23620790
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23620790
          supporting_text: CBAP functions as a novel component in 
            chemokine-induced ZAP70-mediated T-cell adhesion and migration.
  - term:
      id: GO:0005911
      label: cell-cell junction
    evidence_type: IDA
    original_reference_id: PMID:23793062
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23793062
          supporting_text: The lymphoid lineage-specific actin-uncapping protein
            Rltpr is essential for costimulation via CD28 and the development of
            regulatory T cells.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900026
      label: positive regulation of substrate adhesion-dependent cell spreading
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060501
      label: positive regulation of epithelial cell proliferation involved in 
        lung morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:23219958
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23219958
          supporting_text: Dec 5. CDC42 is required for structural patterning of
            the lung during development.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10954424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10954424
          supporting_text: The mammalian homologue of the Caenorhabditis elegans
            polarity protein PAR-6 is a binding partner for the Rho GTPases 
            Cdc42 and Rac1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11035016
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11035016
          supporting_text: A new family of Cdc42 effector proteins, CEPs, 
            function in fibroblast and epithelial cell shape changes.
  - term:
      id: GO:0003161
      label: cardiac conduction system development
    evidence_type: IGI
    original_reference_id: PMID:21690310
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21690310
          supporting_text: Jun 20. Tinman/Nkx2-5 acts via miR-1 and upstream of 
            Cdc42 to regulate heart function across species.
  - term:
      id: GO:0060047
      label: heart contraction
    evidence_type: IGI
    original_reference_id: PMID:21690310
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21690310
          supporting_text: Jun 20. Tinman/Nkx2-5 acts via miR-1 and upstream of 
            Cdc42 to regulate heart function across species.
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:21048939
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21048939
          supporting_text: ARHGEF7 (Beta-PIX) acts as guanine nucleotide 
            exchange factor for leucine-rich repeat kinase 2.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17000758
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17000758
          supporting_text: Sep 25. Ccpg1, a novel scaffold protein that 
            regulates the activity of the Rho guanine nucleotide exchange factor
            Dbs.
  - term:
      id: GO:0030496
      label: midbody
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032467
      label: positive regulation of cytokinesis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051233
      label: spindle midzone
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051489
      label: regulation of filopodium assembly
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051988
      label: regulation of attachment of spindle microtubules to kinetochore
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072686
      label: mitotic spindle
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:19796622
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19796622
          supporting_text: Uncovering early response of gene regulatory networks
            in ESCs by systematic induction of transcription factors.
  - term:
      id: GO:0071944
      label: cell periphery
    evidence_type: IDA
    original_reference_id: PMID:19796622
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19796622
          supporting_text: Uncovering early response of gene regulatory networks
            in ESCs by systematic induction of transcription factors.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:15775979
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15775979
          supporting_text: Mar 3. E-cadherin is essential for in vivo epidermal 
            barrier function by regulating tight junctions.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:19244314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19244314
          supporting_text: Cdo promotes neuronal differentiation via activation 
            of the p38 mitogen-activated protein kinase pathway.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: ISA
    original_reference_id: PMID:12637522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12637522
          supporting_text: 2003 Mar 13. Multifunctional roles for the PH domain 
            of Dbs in regulating Rho GTPase activation.
  - term:
      id: GO:0007097
      label: nuclear migration
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0008104
      label: intracellular protein localization
    evidence_type: IMP
    original_reference_id: PMID:16621792
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16621792
          supporting_text: 'Epub 2006 Apr 17. Membrane localization of adenomatous
            polyposis coli protein at cellular protrusions: targeting sequences and
            regulation by beta-catenin.'
  - term:
      id: GO:0034332
      label: adherens junction organization
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0035088
      label: establishment or maintenance of apical/basal cell polarity
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0051647
      label: nucleus localization
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0007088
      label: regulation of mitotic nuclear division
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0045177
      label: apical part of cell
    evidence_type: IDA
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0048664
      label: neuron fate determination
    evidence_type: IMP
    original_reference_id: PMID:16892058
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16892058
          supporting_text: The Rho-GTPase cdc42 regulates neural progenitor fate
            at the apical surface.
  - term:
      id: GO:0007163
      label: establishment or maintenance of cell polarity
    evidence_type: TAS
    original_reference_id: PMID:10954424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10954424
          supporting_text: The mammalian homologue of the Caenorhabditis elegans
            polarity protein PAR-6 is a binding partner for the Rho GTPases 
            Cdc42 and Rac1.
  - term:
      id: GO:0016197
      label: endosomal transport
    evidence_type: TAS
    original_reference_id: PMID:10954424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10954424
          supporting_text: The mammalian homologue of the Caenorhabditis elegans
            polarity protein PAR-6 is a binding partner for the Rho GTPases 
            Cdc42 and Rac1.
  - term:
      id: GO:0098609
      label: cell-cell adhesion
    evidence_type: TAS
    original_reference_id: PMID:10954424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10954424
          supporting_text: The mammalian homologue of the Caenorhabditis elegans
            polarity protein PAR-6 is a binding partner for the Rho GTPases 
            Cdc42 and Rac1.
  - term:
      id: GO:0007097
      label: nuclear migration
    evidence_type: IMP
    original_reference_id: PMID:15882626
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15882626
          supporting_text: Nuclear movement regulated by Cdc42, MRCK, myosin, 
            and actin flow establishes MTOC polarization in migrating cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15996550
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15996550
          supporting_text: The Rho-specific GEF Lfc interacts with neurabin and 
            spinophilin to regulate dendritic spine morphology.
  - term:
      id: GO:0042995
      label: cell projection
    evidence_type: IDA
    original_reference_id: PMID:15728722
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15728722
          supporting_text: Feb 23. Local phosphatidylinositol 
            3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate 
            Rac1/Cdc42 and initiate neurite outgrowth in nerve growth 
            factor-stimulated PC12 cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IMP
    original_reference_id: PMID:15728722
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15728722
          supporting_text: Feb 23. Local phosphatidylinositol 
            3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate 
            Rac1/Cdc42 and initiate neurite outgrowth in nerve growth 
            factor-stimulated PC12 cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16052498
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16052498
          supporting_text: Expression, synaptic localization, and developmental 
            regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly 
            expressed in the developing and adult brain.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12773384
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12773384
          supporting_text: TCGAP, a multidomain Rho GTPase-activating protein 
            involved in insulin-stimulated glucose transport.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IDA
    original_reference_id: PMID:15249579
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15249579
          supporting_text: Jul 12. Vav GEFs are required for beta2 
            integrin-dependent functions of neutrophils.
  - term:
      id: GO:0030742
      label: GTP-dependent protein binding
    evidence_type: IPI
    original_reference_id: PMID:10954424
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10954424
          supporting_text: The mammalian homologue of the Caenorhabditis elegans
            polarity protein PAR-6 is a binding partner for the Rho GTPases 
            Cdc42 and Rac1.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: IDA
    original_reference_id: PMID:10699171
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10699171
          supporting_text: Functional analysis of ARHGAP6, a novel 
            GTPase-activating protein for RhoA.
  - term:
      id: GO:0046847
      label: filopodium assembly
    evidence_type: IDA
    original_reference_id: PMID:10699171
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10699171
          supporting_text: Functional analysis of ARHGAP6, a novel 
            GTPase-activating protein for RhoA.
  - term:
      id: GO:0003924
      label: GTPase activity
    evidence_type: TAS
    original_reference_id: PMID:10490598
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10490598
          supporting_text: The Borgs, a new family of Cdc42 and TC10 
            GTPase-interacting proteins.
  - term:
      id: GO:0007266
      label: Rho protein signal transduction
    evidence_type: TAS
    original_reference_id: PMID:10490598
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10490598
          supporting_text: The Borgs, a new family of Cdc42 and TC10 
            GTPase-interacting proteins.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000003
    title: Gene Ontology annotation based on Enzyme Commission mapping
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10490598
    title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting 
      proteins.
    findings: []
  - id: PMID:10699171
    title: Functional analysis of ARHGAP6, a novel GTPase-activating protein for
      RhoA.
    findings: []
  - id: PMID:10954424
    title: The mammalian homologue of the Caenorhabditis elegans polarity 
      protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1.
    findings: []
  - id: PMID:11035016
    title: A new family of Cdc42 effector proteins, CEPs, function in fibroblast
      and epithelial cell shape changes.
    findings: []
  - id: PMID:12123608
    title: Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA 
      and growth cone morphology.
    findings: []
  - id: PMID:12637522
    title: Multifunctional roles for the PH domain of Dbs in regulating Rho 
      GTPase activation.
    findings: []
  - id: PMID:12773384
    title: TCGAP, a multidomain Rho GTPase-activating protein involved in 
      insulin-stimulated glucose transport.
    findings: []
  - id: PMID:15249579
    title: Vav GEFs are required for beta2 integrin-dependent functions of 
      neutrophils.
    findings: []
  - id: PMID:15537656
    title: A direct interaction between Cdc42 and vesicle-associated membrane 
      protein 2 regulates SNARE-dependent insulin exocytosis.
    findings: []
  - id: PMID:15710388
    title: 'Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor
      expressed predominantly in lymphocytes.'
    findings: []
  - id: PMID:15728722
    title: Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits 
      Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in 
      nerve growth factor-stimulated PC12 cells.
    findings: []
  - id: PMID:15775979
    title: E-cadherin is essential for in vivo epidermal barrier function by 
      regulating tight junctions.
    findings: []
  - id: PMID:15882626
    title: Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow 
      establishes MTOC polarization in migrating cells.
    findings: []
  - id: PMID:15996550
    title: The Rho-specific GEF Lfc interacts with neurabin and spinophilin to 
      regulate dendritic spine morphology.
    findings: []
  - id: PMID:16052498
    title: Expression, synaptic localization, and developmental regulation of 
      Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the 
      developing and adult brain.
    findings: []
  - id: PMID:16621792
    title: 'Membrane localization of adenomatous polyposis coli protein at cellular
      protrusions: targeting sequences and regulation by beta-catenin.'
    findings: []
  - id: PMID:16892058
    title: The Rho-GTPase cdc42 regulates neural progenitor fate at the apical 
      surface.
    findings: []
  - id: PMID:17000758
    title: Ccpg1, a novel scaffold protein that regulates the activity of the 
      Rho guanine nucleotide exchange factor Dbs.
    findings: []
  - id: PMID:17634366
    title: Proteolipid protein is required for transport of sirtuin 2 into CNS 
      myelin.
    findings: []
  - id: PMID:18325335
    title: Affixin activates Rac1 via betaPIX in C2C12 myoblast.
    findings: []
  - id: PMID:18541910
    title: Bves directly interacts with GEFT, and controls cell shape and 
      movement through regulation of Rac1/Cdc42 activity.
    findings: []
  - id: PMID:18604197
    title: IQGAP3 regulates cell proliferation through the Ras/ERK signalling 
      cascade.
    findings: []
  - id: PMID:18838382
    title: FGD2, a CDC42-specific exchange factor expressed by 
      antigen-presenting cells, localizes to early endosomes and active membrane
      ruffles.
    findings: []
  - id: PMID:18854161
    title: ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and
      has ATPase activity.
    findings: []
  - id: PMID:19144319
    title: The phagosomal proteome in interferon-gamma-activated macrophages.
    findings: []
  - id: PMID:19244314
    title: Cdo promotes neuronal differentiation via activation of the p38 
      mitogen-activated protein kinase pathway.
    findings: []
  - id: PMID:19796622
    title: Uncovering early response of gene regulatory networks in ESCs by 
      systematic induction of transcription factors.
    findings: []
  - id: PMID:19893577
    title: The adenomatous polyposis coli-associated exchange factors Asef and 
      Asef2 are required for adenoma formation in Apc(Min/+)mice.
    findings: []
  - id: PMID:21048939
    title: ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for 
      leucine-rich repeat kinase 2.
    findings: []
  - id: PMID:21690310
    title: Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart 
      function across species.
    findings: []
  - id: PMID:21828338
    title: Cool-1/βPIX functions as a guanine nucleotide exchange factor in the 
      cycling of Cdc42 to regulate insulin secretion.
    findings: []
  - id: PMID:22461490
    title: DOCK8 is a Cdc42 activator critical for interstitial dendritic cell 
      migration during immune responses.
    findings: []
  - id: PMID:22494997
    title: Age-related guanine nucleotide exchange factor, mouse Zizimin2, 
      induces filopodia in bone marrow-derived dendritic cells.
    findings: []
  - id: PMID:23219958
    title: CDC42 is required for structural patterning of the lung during 
      development.
    findings: []
  - id: PMID:23620790
    title: CBAP functions as a novel component in chemokine-induced 
      ZAP70-mediated T-cell adhesion and migration.
    findings: []
  - id: PMID:23706742
    title: RAS and RHO families of GTPases directly regulate distinct 
      phosphoinositide 3-kinase isoforms.
    findings: []
  - id: PMID:23793062
    title: The lymphoid lineage-specific actin-uncapping protein Rltpr is 
      essential for costimulation via CD28 and the development of regulatory T 
      cells.
    findings: []
  - id: PMID:24076653
    title: CDC42 switches IRSp53 from inhibition of actin growth to elongation 
      by clustering of VASP.
    findings: []
  - id: PMID:24792215
    title: CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and 
      actin-dependent events.
    findings: []
  - id: PMID:25197047
    title: Essential role of sympathetic endothelin A receptors for adverse 
      cardiac remodeling.
    findings: []
  - id: PMID:25217619
    title: Phosphoinositide 3-kinase p85beta regulates invadopodium formation.
    findings: []
  - id: PMID:25851601
    title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
    findings: []
  - id: PMID:27917469
    title: Association of dysfunctional synapse defective 1 (SYDE1) with 
      restricted fetal growth - SYDE1 regulates placental cell migration and 
      invasion.
    findings: []
  - id: PMID:31219639
    title: Cdc42 activation by endothelin regulates neural crest cell migration 
      in the cardiac outflow tract.
    findings: []
  - id: PMID:33531495
    title: Photoactivatable CaMKII induces synaptic plasticity in single 
      synapses.
    findings: []
  - id: PMID:37140151
    title: Biallelic variants in IQCN cause sperm flagellar assembly defects and
      male infertility.
    findings: []
  - id: PMID:8464478
    title: Oncogene ect2 is related to regulators of small GTP-binding proteins.
    findings: []
  - id: Reactome:R-MMU-3928643
    title: Activation of CDC42 by intersectin-1
    findings: []
  - id: Reactome:R-MMU-442572
    title: Activation of WASP and N-WASP by CDC42
    findings: []
  - id: Reactome:R-MMU-448947
    title: Interaction of Bnip-2 with Cdc42
    findings: []
  - id: Reactome:R-MMU-5665684
    title: Fmnl1 binds Cdc42:GTP
    findings: []