Cdk5r1

UniProt ID: P61809
Organism: Mus musculus
Review Status: INITIALIZED
📝 Provide Detailed Feedback

Gene Description

TODO: Add description for Cdk5r1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007420 brain development
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007411 axon guidance
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030426 growth cone
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016533 protein kinase 5 complex
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0021722 superior olivary nucleus maturation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0021819 layer formation in cerebral cortex
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043005 neuron projection
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043204 perikaryon
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048511 rhythmic process
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17341134
Cdk5 is involved in BDNF-stimulated dendritic growth in hipp... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17341134
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
GO:0005515 protein binding
IPI
PMID:18325333
CDK5 activator p35 downregulates E-cadherin precursor indepe... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18325333
Epub 2008 Mar 4. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5.
GO:0005515 protein binding
IPI
PMID:24561619
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell funct... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24561619
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
GO:0016533 protein kinase 5 complex
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043539 protein serine/threonine kinase activator activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045892 negative regulation of DNA-templated transcription
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0018105 peptidyl-serine phosphorylation
ISO
GO_REF:0000119 		MODIFY
Summary: OVER-ANNOTATION: Cdk5r1 (p35) does NOT catalyze phosphorylation itself - it is a "neuron specific activator of CDK5" (UniProt). UniProt explicitly states "Only the heterodimer shows kinase activity." The kinase activity belongs to CDK5, not to p35. The correct annotation should be to kinase activator activity (GO:0061575 already annotated via IMP) rather than the phosphorylation process.
GO:0018107 peptidyl-threonine phosphorylation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005509 calcium ion binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009792 embryo development ending in birth or egg hatching
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016533 protein kinase 5 complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030182 neuron differentiation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030424 axon
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030425 dendrite
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030426 growth cone
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031175 neuron projection development
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031594 neuromuscular junction
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035235 ionotropic glutamate receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043025 neuronal cell body
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043197 dendritic spine
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043292 contractile muscle fiber
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043525 positive regulation of neuron apoptotic process
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043539 protein serine/threonine kinase activator activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043539 protein serine/threonine kinase activator activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045296 cadherin binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045348 positive regulation of MHC class II biosynthetic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045892 negative regulation of DNA-templated transcription
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098693 regulation of synaptic vesicle cycle
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098793 presynapse
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-9634937 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070315 G1 to G0 transition involved in cell differentiation
IMP
PMID:21566658
A novel RING finger protein, Znf179, modulates cell cycle ex... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21566658
2011 May 13. A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
IMP
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
TAS
PMID:12516540
The TGF-beta response to Leishmania chagasi in the absence o... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12516540
The TGF-beta response to Leishmania chagasi in the absence of IL-12.
GO:0009792 embryo development ending in birth or egg hatching
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003779 actin binding
IPI
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
GO:0002020 protease binding
IPI
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
GO:0019901 protein kinase binding
IPI
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
GO:0035255 ionotropic glutamate receptor binding
IPI
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
GO:0051015 actin filament binding
IPI
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
GO:0042501 serine phosphorylation of STAT protein
IDA
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
GO:0005654 nucleoplasm
TAS
Reactome:R-MMU-8868356 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-MMU-8868383 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-8863416 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-8868331 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-8868583 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-8868589 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-MMU-8868677 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-NUL-8870566 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-8863416 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18054859
Cdk5 promotes synaptogenesis by regulating the subcellular d... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18054859
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.
GO:0090314 positive regulation of protein targeting to membrane
IDA
PMID:18054859
Cdk5 promotes synaptogenesis by regulating the subcellular d... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18054859
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.
GO:0001764 neuron migration
IGI
PMID:11226314
Synergistic contributions of cyclin-dependant kinase 5/p35 a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11226314
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.
GO:0001764 neuron migration
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0005515 protein binding
IPI
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
GO:0005515 protein binding
IPI
PMID:15489224
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15489224
2004 Oct 15. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
GO:0005515 protein binding
IPI
PMID:17529984
Cyclin-dependent kinase 5 governs learning and synaptic plas... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17529984
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.
GO:0005515 protein binding
IPI
PMID:17591690
Stabilization and activation of p53 induced by Cdk5 contribu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17591690
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
GO:0005634 nucleus
IDA
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
GO:0005634 nucleus
IDA
PMID:17591690
Stabilization and activation of p53 induced by Cdk5 contribu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17591690
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
GO:0005737 cytoplasm
IDA
PMID:15123626
Cyclin-dependent kinase 5 associated with p39 promotes Munc1... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15123626
2004 Apr 26. Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.
GO:0021549 cerebellum development
IMP
PMID:11226314
Synergistic contributions of cyclin-dependant kinase 5/p35 a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11226314
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.
GO:0021549 cerebellum development
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0021722 superior olivary nucleus maturation
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0021766 hippocampus development
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0021819 layer formation in cerebral cortex
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0045860 positive regulation of protein kinase activity
IGI
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 func... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
GO:0005515 protein binding
IPI
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction thr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
GO:0014069 postsynaptic density
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048013 ephrin receptor signaling pathway
IMP
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction thr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
GO:0061001 regulation of dendritic spine morphogenesis
IMP
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction thr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
GO:0021799 cerebral cortex radially oriented cell migration
IMP
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortic... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
GO:0032956 regulation of actin cytoskeleton organization
IMP
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortic... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
GO:0070507 regulation of microtubule cytoskeleton organization
IMP
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortic... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
GO:0005515 protein binding
IPI
PMID:11276227
Cdk5 is involved in neuregulin-induced AChR expression at th... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11276227
Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction.
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001764 neuron migration
IDA
PMID:9010203
Mice lacking p35, a neuronal specific activator of Cdk5, dis... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9010203
Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.
GO:0005509 calcium ion binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007158 neuron cell-cell adhesion
IMP
PMID:10753743
Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 k... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10753743
Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase.
GO:0007411 axon guidance
IMP
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice.
GO:0007413 axonal fasciculation
IMP
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice.
GO:0007420 brain development
IMP
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice.
GO:0016020 membrane
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030182 neuron differentiation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030424 axon
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030425 dendrite
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030426 growth cone
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031175 neuron projection development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031594 neuromuscular junction
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035235 ionotropic glutamate receptor signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043025 neuronal cell body
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043197 dendritic spine
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043292 contractile muscle fiber
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043525 positive regulation of neuron apoptotic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043539 protein serine/threonine kinase activator activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045296 cadherin binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12496365
CDK5 regulates cell adhesion and migration in corneal epithe... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12496365
CDK5 regulates cell adhesion and migration in corneal epithelial cells.
GO:0008092 cytoskeletal protein binding
TAS
PMID:12496365
CDK5 regulates cell adhesion and migration in corneal epithe... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12496365
CDK5 regulates cell adhesion and migration in corneal epithelial cells.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10545161
Callosal axon guidance defects in p35(-/-) mice.
PMID:10753743
Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase.
PMID:11226314
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.
PMID:11276227
Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction.
PMID:11517264
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
PMID:12496365
CDK5 regulates cell adhesion and migration in corneal epithelial cells.
PMID:12516540
The TGF-beta response to Leishmania chagasi in the absence of IL-12.
PMID:15096606
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
PMID:15123626
Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.
PMID:15489224
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
PMID:17143272
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
PMID:17341134
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
PMID:17529984
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.
PMID:17591690
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
PMID:18054859
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.
PMID:18325333
CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5.
PMID:19118186
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
PMID:20624590
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
PMID:21566658
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
PMID:24561619
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
PMID:9010203
Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.
Reactome:R-MMU-8863416
Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)
Reactome:R-MMU-8868331
Cdk5:p25 phosphorylates Golga2
Reactome:R-MMU-8868356
Cdk5:p25 phosphorylates lamin A
Reactome:R-MMU-8868383
Cdk5:p25 phosphorylates lamin B1
Reactome:R-MMU-8868583
Cdk5:p25 phosphorylates Prdx1
Reactome:R-MMU-8868589
Cdk5:p25 phosphorylates Prdx2
Reactome:R-MMU-8868677
Cdk5:p25 phosphorylates Jun
Reactome:R-MMU-9634937
Cdk5r1 gene expression is stimulated by Npas4
Reactome:R-NUL-8870566
Cdk5:p25 phosphorylates FOXO3

📄 View Raw YAML

 
id: P61809
gene_symbol: Cdk5r1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Cdk5r1'
existing_annotations:
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007420
      label: brain development
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007411
      label: axon guidance
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030426
      label: growth cone
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016533
      label: protein kinase 5 complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0021722
      label: superior olivary nucleus maturation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0021819
      label: layer formation in cerebral cortex
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043005
      label: neuron projection
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043204
      label: perikaryon
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048511
      label: rhythmic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17341134
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17341134
          supporting_text: Cdk5 is involved in BDNF-stimulated dendritic growth 
            in hippocampal neurons.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18325333
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18325333
          supporting_text: Epub 2008 Mar 4. CDK5 activator p35 downregulates 
            E-cadherin precursor independently of CDK5.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24561619
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24561619
          supporting_text: Role of the SIK2-p35-PJA2 complex in pancreatic 
            β-cell functional compensation.
  - term:
      id: GO:0016533
      label: protein kinase 5 complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043539
      label: protein serine/threonine kinase activator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0018105
      label: peptidyl-serine phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: >-
        OVER-ANNOTATION: Cdk5r1 (p35) does NOT catalyze phosphorylation itself - it
        is
        a "neuron specific activator of CDK5" (UniProt). UniProt explicitly states
        "Only
        the heterodimer shows kinase activity." The kinase activity belongs to CDK5,
        not
        to p35. The correct annotation should be to kinase activator activity (GO:0061575
        already annotated via IMP) rather than the phosphorylation process.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
  - term:
      id: GO:0018107
      label: peptidyl-threonine phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000307
      label: cyclin-dependent protein kinase holoenzyme complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007213
      label: G protein-coupled acetylcholine receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009792
      label: embryo development ending in birth or egg hatching
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014069
      label: postsynaptic density
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016533
      label: protein kinase 5 complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030182
      label: neuron differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030424
      label: axon
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030426
      label: growth cone
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031175
      label: neuron projection development
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031594
      label: neuromuscular junction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035235
      label: ionotropic glutamate receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043197
      label: dendritic spine
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043292
      label: contractile muscle fiber
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043525
      label: positive regulation of neuron apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043539
      label: protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043539
      label: protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045296
      label: cadherin binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045348
      label: positive regulation of MHC class II biosynthetic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046875
      label: ephrin receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048471
      label: perinuclear region of cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0098693
      label: regulation of synaptic vesicle cycle
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0098793
      label: presynapse
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1903265
      label: positive regulation of tumor necrosis factor-mediated signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9634937
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070315
      label: G1 to G0 transition involved in cell differentiation
    evidence_type: IMP
    original_reference_id: PMID:21566658
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21566658
          supporting_text: 2011 May 13. A novel RING finger protein, Znf179, 
            modulates cell cycle exit and neuronal differentiation of P19 
            embryonal carcinoma cells.
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: IMP
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0061575
      label: cyclin-dependent protein serine/threonine kinase activator activity
    evidence_type: TAS
    original_reference_id: PMID:12516540
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12516540
          supporting_text: The TGF-beta response to Leishmania chagasi in the 
            absence of IL-12.
  - term:
      id: GO:0009792
      label: embryo development ending in birth or egg hatching
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003779
      label: actin binding
    evidence_type: IPI
    original_reference_id: PMID:19118186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19118186
          supporting_text: Spatial learning impairment, enhanced CDK5/p35 
            activity, and downregulation of NMDA receptor expression in 
            transgenic mice expressing tau-tubulin kinase 1.
  - term:
      id: GO:0002020
      label: protease binding
    evidence_type: IPI
    original_reference_id: PMID:19118186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19118186
          supporting_text: Spatial learning impairment, enhanced CDK5/p35 
            activity, and downregulation of NMDA receptor expression in 
            transgenic mice expressing tau-tubulin kinase 1.
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: IPI
    original_reference_id: PMID:19118186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19118186
          supporting_text: Spatial learning impairment, enhanced CDK5/p35 
            activity, and downregulation of NMDA receptor expression in 
            transgenic mice expressing tau-tubulin kinase 1.
  - term:
      id: GO:0035255
      label: ionotropic glutamate receptor binding
    evidence_type: IPI
    original_reference_id: PMID:19118186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19118186
          supporting_text: Spatial learning impairment, enhanced CDK5/p35 
            activity, and downregulation of NMDA receptor expression in 
            transgenic mice expressing tau-tubulin kinase 1.
  - term:
      id: GO:0051015
      label: actin filament binding
    evidence_type: IPI
    original_reference_id: PMID:19118186
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19118186
          supporting_text: Spatial learning impairment, enhanced CDK5/p35 
            activity, and downregulation of NMDA receptor expression in 
            transgenic mice expressing tau-tubulin kinase 1.
  - term:
      id: GO:0042501
      label: serine phosphorylation of STAT protein
    evidence_type: IDA
    original_reference_id: PMID:15096606
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15096606
          supporting_text: Cyclin-dependent kinase 5 phosphorylates signal 
            transducer and activator of transcription 3 and regulates its 
            transcriptional activity.
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868356
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005654
      label: nucleoplasm
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868383
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8863416
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868331
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868589
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8868677
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-NUL-8870566
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-8863416
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18054859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18054859
          supporting_text: Cdk5 promotes synaptogenesis by regulating the 
            subcellular distribution of the MAGUK family member CASK.
  - term:
      id: GO:0090314
      label: positive regulation of protein targeting to membrane
    evidence_type: IDA
    original_reference_id: PMID:18054859
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18054859
          supporting_text: Cdk5 promotes synaptogenesis by regulating the 
            subcellular distribution of the MAGUK family member CASK.
  - term:
      id: GO:0001764
      label: neuron migration
    evidence_type: IGI
    original_reference_id: PMID:11226314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11226314
          supporting_text: Synergistic contributions of cyclin-dependant kinase 
            5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the 
            developing mouse brain.
  - term:
      id: GO:0001764
      label: neuron migration
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15096606
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15096606
          supporting_text: Cyclin-dependent kinase 5 phosphorylates signal 
            transducer and activator of transcription 3 and regulates its 
            transcriptional activity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:15489224
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15489224
          supporting_text: 2004 Oct 15. Cdk5/p35 phosphorylates mSds3 and 
            regulates mSds3-mediated repression of transcription.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17529984
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17529984
          supporting_text: Cyclin-dependent kinase 5 governs learning and 
            synaptic plasticity via control of NMDAR degradation.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17591690
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17591690
          supporting_text: Stabilization and activation of p53 induced by Cdk5 
            contributes to neuronal cell death.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:15096606
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15096606
          supporting_text: Cyclin-dependent kinase 5 phosphorylates signal 
            transducer and activator of transcription 3 and regulates its 
            transcriptional activity.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:17591690
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17591690
          supporting_text: Stabilization and activation of p53 induced by Cdk5 
            contributes to neuronal cell death.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:15123626
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15123626
          supporting_text: 2004 Apr 26. Cyclin-dependent kinase 5 associated 
            with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent 
            exocytosis.
  - term:
      id: GO:0021549
      label: cerebellum development
    evidence_type: IMP
    original_reference_id: PMID:11226314
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11226314
          supporting_text: Synergistic contributions of cyclin-dependant kinase 
            5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the 
            developing mouse brain.
  - term:
      id: GO:0021549
      label: cerebellum development
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0021722
      label: superior olivary nucleus maturation
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0021766
      label: hippocampus development
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0021819
      label: layer formation in cerebral cortex
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: IGI
    original_reference_id: PMID:11517264
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11517264
          supporting_text: p35 and p39 are essential for cyclin-dependent kinase
            5 function during neurodevelopment.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17143272
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17143272
          supporting_text: Cdk5 regulates EphA4-mediated dendritic spine 
            retraction through an ephexin1-dependent mechanism.
  - term:
      id: GO:0014069
      label: postsynaptic density
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048013
      label: ephrin receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:17143272
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17143272
          supporting_text: Cdk5 regulates EphA4-mediated dendritic spine 
            retraction through an ephexin1-dependent mechanism.
  - term:
      id: GO:0061001
      label: regulation of dendritic spine morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:17143272
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17143272
          supporting_text: Cdk5 regulates EphA4-mediated dendritic spine 
            retraction through an ephexin1-dependent mechanism.
  - term:
      id: GO:0021799
      label: cerebral cortex radially oriented cell migration
    evidence_type: IMP
    original_reference_id: PMID:20624590
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20624590
          supporting_text: Dixdc1 is a critical regulator of DISC1 and embryonic
            cortical development.
  - term:
      id: GO:0032956
      label: regulation of actin cytoskeleton organization
    evidence_type: IMP
    original_reference_id: PMID:20624590
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20624590
          supporting_text: Dixdc1 is a critical regulator of DISC1 and embryonic
            cortical development.
  - term:
      id: GO:0070507
      label: regulation of microtubule cytoskeleton organization
    evidence_type: IMP
    original_reference_id: PMID:20624590
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20624590
          supporting_text: Dixdc1 is a critical regulator of DISC1 and embryonic
            cortical development.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11276227
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11276227
          supporting_text: Cdk5 is involved in neuregulin-induced AChR 
            expression at the neuromuscular junction.
  - term:
      id: GO:0007213
      label: G protein-coupled acetylcholine receptor signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001764
      label: neuron migration
    evidence_type: IDA
    original_reference_id: PMID:9010203
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9010203
          supporting_text: Mice lacking p35, a neuronal specific activator of 
            Cdk5, display cortical lamination defects, seizures, and adult 
            lethality.
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007158
      label: neuron cell-cell adhesion
    evidence_type: IMP
    original_reference_id: PMID:10753743
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10753743
          supporting_text: Regulation of N-cadherin-mediated adhesion by the 
            p35-Cdk5 kinase.
  - term:
      id: GO:0007411
      label: axon guidance
    evidence_type: IMP
    original_reference_id: PMID:10545161
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10545161
          supporting_text: Callosal axon guidance defects in p35(-/-) mice.
  - term:
      id: GO:0007413
      label: axonal fasciculation
    evidence_type: IMP
    original_reference_id: PMID:10545161
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10545161
          supporting_text: Callosal axon guidance defects in p35(-/-) mice.
  - term:
      id: GO:0007420
      label: brain development
    evidence_type: IMP
    original_reference_id: PMID:10545161
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10545161
          supporting_text: Callosal axon guidance defects in p35(-/-) mice.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030182
      label: neuron differentiation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030424
      label: axon
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030426
      label: growth cone
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031175
      label: neuron projection development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031594
      label: neuromuscular junction
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035235
      label: ionotropic glutamate receptor signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043197
      label: dendritic spine
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043292
      label: contractile muscle fiber
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043525
      label: positive regulation of neuron apoptotic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043539
      label: protein serine/threonine kinase activator activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045296
      label: cadherin binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12496365
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12496365
          supporting_text: CDK5 regulates cell adhesion and migration in corneal
            epithelial cells.
  - term:
      id: GO:0008092
      label: cytoskeletal protein binding
    evidence_type: TAS
    original_reference_id: PMID:12496365
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12496365
          supporting_text: CDK5 regulates cell adhesion and migration in corneal
            epithelial cells.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10545161
    title: Callosal axon guidance defects in p35(-/-) mice.
    findings: []
  - id: PMID:10753743
    title: Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase.
    findings: []
  - id: PMID:11226314
    title: Synergistic contributions of cyclin-dependant kinase 5/p35 and 
      Reelin/Dab1 to the positioning of cortical neurons in the developing mouse
      brain.
    findings: []
  - id: PMID:11276227
    title: Cdk5 is involved in neuregulin-induced AChR expression at the 
      neuromuscular junction.
    findings: []
  - id: PMID:11517264
    title: p35 and p39 are essential for cyclin-dependent kinase 5 function 
      during neurodevelopment.
    findings: []
  - id: PMID:12496365
    title: CDK5 regulates cell adhesion and migration in corneal epithelial 
      cells.
    findings: []
  - id: PMID:12516540
    title: The TGF-beta response to Leishmania chagasi in the absence of IL-12.
    findings: []
  - id: PMID:15096606
    title: Cyclin-dependent kinase 5 phosphorylates signal transducer and 
      activator of transcription 3 and regulates its transcriptional activity.
    findings: []
  - id: PMID:15123626
    title: Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 
      phosphorylation and Ca(2+)-dependent exocytosis.
    findings: []
  - id: PMID:15489224
    title: Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression
      of transcription.
    findings: []
  - id: PMID:17143272
    title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an 
      ephexin1-dependent mechanism.
    findings: []
  - id: PMID:17341134
    title: Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal 
      neurons.
    findings: []
  - id: PMID:17529984
    title: Cyclin-dependent kinase 5 governs learning and synaptic plasticity 
      via control of NMDAR degradation.
    findings: []
  - id: PMID:17591690
    title: Stabilization and activation of p53 induced by Cdk5 contributes to 
      neuronal cell death.
    findings: []
  - id: PMID:18054859
    title: Cdk5 promotes synaptogenesis by regulating the subcellular 
      distribution of the MAGUK family member CASK.
    findings: []
  - id: PMID:18325333
    title: CDK5 activator p35 downregulates E-cadherin precursor independently 
      of CDK5.
    findings: []
  - id: PMID:19118186
    title: Spatial learning impairment, enhanced CDK5/p35 activity, and 
      downregulation of NMDA receptor expression in transgenic mice expressing 
      tau-tubulin kinase 1.
    findings: []
  - id: PMID:20624590
    title: Dixdc1 is a critical regulator of DISC1 and embryonic cortical 
      development.
    findings: []
  - id: PMID:21566658
    title: A novel RING finger protein, Znf179, modulates cell cycle exit and 
      neuronal differentiation of P19 embryonal carcinoma cells.
    findings: []
  - id: PMID:24561619
    title: Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional 
      compensation.
    findings: []
  - id: PMID:9010203
    title: Mice lacking p35, a neuronal specific activator of Cdk5, display 
      cortical lamination defects, seizures, and adult lethality.
    findings: []
  - id: Reactome:R-MMU-8863416
    title: Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)
    findings: []
  - id: Reactome:R-MMU-8868331
    title: Cdk5:p25 phosphorylates Golga2
    findings: []
  - id: Reactome:R-MMU-8868356
    title: Cdk5:p25 phosphorylates lamin A
    findings: []
  - id: Reactome:R-MMU-8868383
    title: Cdk5:p25 phosphorylates lamin B1
    findings: []
  - id: Reactome:R-MMU-8868583
    title: Cdk5:p25 phosphorylates Prdx1
    findings: []
  - id: Reactome:R-MMU-8868589
    title: Cdk5:p25 phosphorylates Prdx2
    findings: []
  - id: Reactome:R-MMU-8868677
    title: Cdk5:p25 phosphorylates Jun
    findings: []
  - id: Reactome:R-MMU-9634937
    title: Cdk5r1 gene expression is stimulated by Npas4
    findings: []
  - id: Reactome:R-NUL-8870566
    title: Cdk5:p25 phosphorylates FOXO3
    findings: []