Cdk5r1 encodes p35, a neuron-enriched regulatory activator of CDK5, and its calpain-generated p25 cleavage product. p35/p25 are not kinases themselves; they bind CDK5 in the protein kinase 5 complex and activate CDK5-dependent phosphorylation programs that control neuronal migration, cortical lamination, axon guidance, cytoskeletal organization, synaptic development, and neuronal survival. Myristoylated p35 is membrane/cytoplasmic, while p25 is more cytosolic and nuclear, explaining the mixed cellular localization annotations.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | IBA GO_REF:0000033 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md Cdk5r1/p35 is not an enzyme; its primary molecular function is to activate and spatially target the serine/threonine kinase CDK5 by direct binding. |
| GO:0007420 brain development | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0007411 axon guidance | IBA GO_REF:0000033 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0019901 protein kinase binding | IBA GO_REF:0000033 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030426 growth cone | IBA GO_REF:0000033 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0016533 protein kinase 5 complex | IEA GO_REF:0000002 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0021722 superior olivary nucleus maturation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0021819 layer formation in cerebral cortex | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043005 neuron projection | IEA GO_REF:0000044 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043204 perikaryon | IEA GO_REF:0000044 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0048511 rhythmic process | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | IEA GO_REF:0000120 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005515 protein binding | IPI PMID:17341134 Cdk5 is involved in BDNF-stimulated dendritic growth in hipp... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:17341134 Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. |
| GO:0005515 protein binding | IPI PMID:18325333 CDK5 activator p35 downregulates E-cadherin precursor indepe... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:18325333 CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. |
| GO:0005515 protein binding | IPI PMID:24561619 Role of the SIK2-p35-PJA2 complex in pancreatic Ξ²-cell funct... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:24561619 Role of the SIK2-p35-PJA2 complex in pancreatic Ξ²-cell functional compensation. |
| GO:0016533 protein kinase 5 complex | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005654 nucleoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043539 protein serine/threonine kinase activator activity | IEA GO_REF:0000107 | MODIFY | Summary: Supported but less specific than the CDK-specific activator term. Reason: Cdk5r1/p35 activates the cyclin-dependent kinase CDK5; replace this broader serine/threonine kinase activator term with the more specific cyclin-dependent protein serine/threonine kinase activator activity. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity Supporting Evidence: file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting. |
| GO:0045892 negative regulation of DNA-templated transcription | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0018105 peptidyl-serine phosphorylation | ISO GO_REF:0000119 | MODIFY | Summary: The annotation attributes kinase/phosphorylation activity to the CDK5 activator subunit. Reason: Cdk5r1/p35 is not the catalytic kinase; it activates CDK5, so the replacement term better represents the molecular role. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity |
| GO:0018107 peptidyl-threonine phosphorylation | ISO GO_REF:0000119 | MODIFY | Summary: The annotation attributes kinase/phosphorylation activity to the CDK5 activator subunit. Reason: Cdk5r1/p35 is not the catalytic kinase; it activates CDK5, so the replacement term better represents the molecular role. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity |
| GO:0000307 cyclin-dependent protein kinase holoenzyme complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005509 calcium ion binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0005634 nucleus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005654 nucleoplasm | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005737 cytoplasm | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0007213 G protein-coupled acetylcholine receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0009792 embryo development ending in birth or egg hatching | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0014069 postsynaptic density | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0016020 membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0016301 kinase activity | ISO GO_REF:0000096 | MODIFY | Summary: The annotation attributes kinase/phosphorylation activity to the CDK5 activator subunit. Reason: Cdk5r1/p35 is not the catalytic kinase; it activates CDK5, so the replacement term better represents the molecular role. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity |
| GO:0016533 protein kinase 5 complex | ISO GO_REF:0000119 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0019901 protein kinase binding | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0019901 protein kinase binding | ISO GO_REF:0000119 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030182 neuron differentiation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0030424 axon | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030425 dendrite | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030426 growth cone | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0031175 neuron projection development | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0031594 neuromuscular junction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0035235 ionotropic glutamate receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043025 neuronal cell body | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043197 dendritic spine | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043292 contractile muscle fiber | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043525 positive regulation of neuron apoptotic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043539 protein serine/threonine kinase activator activity | ISO GO_REF:0000096 | MODIFY | Summary: Supported but less specific than the CDK-specific activator term. Reason: Cdk5r1/p35 activates the cyclin-dependent kinase CDK5; replace this broader serine/threonine kinase activator term with the more specific cyclin-dependent protein serine/threonine kinase activator activity. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity Supporting Evidence: file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting. |
| GO:0043539 protein serine/threonine kinase activator activity | ISO GO_REF:0000119 | MODIFY | Summary: Supported but less specific than the CDK-specific activator term. Reason: Cdk5r1/p35 activates the cyclin-dependent kinase CDK5; replace this broader serine/threonine kinase activator term with the more specific cyclin-dependent protein serine/threonine kinase activator activity. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity Supporting Evidence: file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting. |
| GO:0045296 cadherin binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0045348 positive regulation of MHC class II biosynthetic process | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0045892 negative regulation of DNA-templated transcription | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0046875 ephrin receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | ISO GO_REF:0000119 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0098693 regulation of synaptic vesicle cycle | ISO GO_REF:0000096 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0098793 presynapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9634937 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0070315 G1 to G0 transition involved in cell differentiation | IMP PMID:21566658 A novel RING finger protein, Znf179, modulates cell cycle ex... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:21566658 A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells. |
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | IMP PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity | TAS PMID:12516540 The TGF-beta response to Leishmania chagasi in the absence o... | REMOVE | Summary: The cited PMID does not support a Cdk5r1/CDK5 activator annotation. Reason: PMID:12516540 is a Leishmania/IL-12/TGF-beta study and does not provide evidence for Cdk5r1 acting as a CDK5 activator. The molecular function is supported elsewhere in this review, but this evidence assertion should not be retained. Supporting Evidence: PMID:12516540 The TGF-beta response to Leishmania chagasi in the absence of IL-12. |
| GO:0009792 embryo development ending in birth or egg hatching | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0003779 actin binding | IPI PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| GO:0002020 protease binding | IPI PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| GO:0019901 protein kinase binding | IPI PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| GO:0035255 ionotropic glutamate receptor binding | IPI PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| GO:0051015 actin filament binding | IPI PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:19118186 Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| GO:0042501 serine phosphorylation of STAT protein | IDA PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer a... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-8868356 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-8868383 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8863416 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8868331 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8868583 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8868589 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005829 cytosol | TAS Reactome:R-MMU-8868677 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-8870566 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-8863416 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0005515 protein binding | IPI PMID:18054859 Cdk5 promotes synaptogenesis by regulating the subcellular d... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:18054859 Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. |
| GO:0090314 positive regulation of protein targeting to membrane | IDA PMID:18054859 Cdk5 promotes synaptogenesis by regulating the subcellular d... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:18054859 Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. |
| GO:0001764 neuron migration | IGI PMID:11226314 Synergistic contributions of cyclin-dependant kinase 5/p35 a... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:11226314 Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. |
| GO:0001764 neuron migration | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0005515 protein binding | IPI PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer a... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. |
| GO:0005515 protein binding | IPI PMID:15489224 Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated r... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:15489224 Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. |
| GO:0005515 protein binding | IPI PMID:17529984 Cyclin-dependent kinase 5 governs learning and synaptic plas... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:17529984 Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. |
| GO:0005515 protein binding | IPI PMID:17591690 Stabilization and activation of p53 induced by Cdk5 contribu... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:17591690 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. |
| GO:0005634 nucleus | IDA PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer a... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:15096606 Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. |
| GO:0005634 nucleus | IDA PMID:17591690 Stabilization and activation of p53 induced by Cdk5 contribu... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:17591690 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. |
| GO:0005737 cytoplasm | IDA PMID:15123626 Cyclin-dependent kinase 5 associated with p39 promotes Munc1... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:15123626 Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. |
| GO:0021549 cerebellum development | IMP PMID:11226314 Synergistic contributions of cyclin-dependant kinase 5/p35 a... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:11226314 Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. |
| GO:0021549 cerebellum development | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0021722 superior olivary nucleus maturation | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0021766 hippocampus development | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0021819 layer formation in cerebral cortex | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
| GO:0045860 positive regulation of protein kinase activity | IGI PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 func... | MODIFY | Summary: Supported, but too broad for the specific Cdk5r1 molecular function. Reason: PMID:11517264 supports p35/p39 requirement for CDK5 function, so the more specific cyclin-dependent protein serine/threonine kinase activator activity term should replace this broad positive regulation of protein kinase activity annotation. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity Supporting Evidence: PMID:11517264 p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting. |
| GO:0005515 protein binding | IPI PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction thr... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. |
| GO:0014069 postsynaptic density | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0048013 ephrin receptor signaling pathway | IMP PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction thr... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. |
| GO:0061001 regulation of dendritic spine morphogenesis | IMP PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction thr... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:17143272 Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. |
| GO:0021799 cerebral cortex radially oriented cell migration | IMP PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortic... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. |
| GO:0032956 regulation of actin cytoskeleton organization | IMP PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortic... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. |
| GO:0070507 regulation of microtubule cytoskeleton organization | IMP PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortic... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:20624590 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. |
| GO:0005515 protein binding | IPI PMID:11276227 Cdk5 is involved in neuregulin-induced AChR expression at th... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:11276227 Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. |
| GO:0007213 G protein-coupled acetylcholine receptor signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0001764 neuron migration | IDA PMID:9010203 Mice lacking p35, a neuronal specific activator of Cdk5, dis... | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:9010203 Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. |
| GO:0005509 calcium ion binding | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0007158 neuron cell-cell adhesion | IMP PMID:10753743 Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 k... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:10753743 Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. |
| GO:0007411 axon guidance | IMP PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. Supporting Evidence: PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. |
| GO:0007413 axonal fasciculation | IMP PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. |
| GO:0007420 brain development | IMP PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:10545161 Callosal axon guidance defects in p35(-/-) mice. |
| GO:0016020 membrane | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0016301 kinase activity | ISS GO_REF:0000024 | MODIFY | Summary: The annotation attributes kinase/phosphorylation activity to the CDK5 activator subunit. Reason: Cdk5r1/p35 is not the catalytic kinase; it activates CDK5, so the replacement term better represents the molecular role. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity |
| GO:0030182 neuron differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0030424 axon | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030425 dendrite | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0030426 growth cone | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0031175 neuron projection development | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0031594 neuromuscular junction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0035235 ionotropic glutamate receptor signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043025 neuronal cell body | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043197 dendritic spine | ISS GO_REF:0000024 | ACCEPT | Summary: Supported core p35/p25-CDK5 regulatory function or neuronal localization/process. Reason: The term reflects Cdk5r1 as the regulatory activator of CDK5 in neuronal migration, axon guidance, cytoskeletal organization, or synaptic development. |
| GO:0043292 contractile muscle fiber | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043525 positive regulation of neuron apoptotic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0043539 protein serine/threonine kinase activator activity | ISS GO_REF:0000024 | MODIFY | Summary: Supported but less specific than the CDK-specific activator term. Reason: Cdk5r1/p35 activates the cyclin-dependent kinase CDK5; replace this broader serine/threonine kinase activator term with the more specific cyclin-dependent protein serine/threonine kinase activator activity. Proposed replacements: cyclin-dependent protein serine/threonine kinase activator activity Supporting Evidence: file:mouse/Cdk5r1/Cdk5r1-deep-research-falcon.md p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting. |
| GO:0045296 cadherin binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. |
| GO:0005515 protein binding | IPI PMID:12496365 CDK5 regulates cell adhesion and migration in corneal epithe... | MARK AS OVER ANNOTATED | Summary: The annotation is too broad, indirect, or poorly supported as a direct Cdk5r1 function. Reason: This term should not be used as a primary functional annotation for p35/p25 because it either describes vague binding or an indirect pathway consequence. Supporting Evidence: PMID:12496365 CDK5 regulates cell adhesion and migration in corneal epithelial cells. |
| GO:0008092 cytoskeletal protein binding | TAS PMID:12496365 CDK5 regulates cell adhesion and migration in corneal epithe... | KEEP AS NON CORE | Summary: Supported but downstream or context-specific Cdk5r1 biology. Reason: The annotation is compatible with p35/p25-CDK5 biology but describes a developmental, synaptic, binding, or localization consequence rather than the primary CDK5 activation role. Supporting Evidence: PMID:12496365 CDK5 regulates cell adhesion and migration in corneal epithelial cells. |
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