Beta-catenin is a multifunctional Armadillo-repeat protein with two conserved core roles: at adherens junctions it binds classical cadherins and alpha-catenin to support cadherin-mediated cell-cell adhesion, and in canonical Wnt signaling it accumulates in the nucleus and acts as a transcriptional coactivator with TCF/LEF-family DNA-binding transcription factors. These molecular roles explain the many developmental, proliferative, differentiation, and tissue-patterning phenotypes in mouse; those organismal processes are generally downstream context-specific consequences rather than separate core molecular functions.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001525 angiogenesis | IMP PMID:28463231 Disruption of lineage specification in adult pulmonary mesen... | KEEP AS NON CORE | Summary: Beta-catenin promotes angiogenesis via endothelial Wnt/TCF transcription and adherens-junction integrity; a vascular developmental consequence, not a core function. Reason: downstream vascular outcome of Wnt and junction roles Supporting Evidence: PMID:28463231 Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. |
| GO:0001708 cell fate specification | IMP PMID:28463231 Disruption of lineage specification in adult pulmonary mesen... | KEEP AS NON CORE | Summary: Beta-catenin specifies cell fates via context-dependent Wnt target activation; a developmental specification outcome, not a proximal molecular mechanism. Reason: downstream Wnt-driven fate specification Supporting Evidence: PMID:28463231 Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. |
| GO:0019221 cytokine-mediated signaling pathway | IMP PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | KEEP AS NON CORE | Summary: Beta-catenin intersects cytokine-responsive transcription via Wnt crosstalk in development/immunity; an indirect signaling outcome rather than a direct cytokine-pathway role. Reason: indirect crosstalk; downgrade from UNDECIDED to non-core Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. |
| GO:0002064 epithelial cell development | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | KEEP AS NON CORE | Summary: Beta-catenin supports epithelial cell development via junction-mediated polarity and Wnt transcription; an epithelial differentiation outcome downstream of its dual role. Reason: downstream of junction/Wnt epithelial roles Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0001944 vasculature development | IMP PMID:25083995 Canonical WNT signaling components in vascular development a... | KEEP AS NON CORE | Summary: Whole-vasculature development depends on beta-catenin Wnt signaling in endothelium; a broad downstream organ-system phenotype. Reason: System-level vascular development downstream of Wnt/beta-catenin output. Supporting Evidence: PMID:25083995 Canonical WNT signaling components in vascular development and barrier formation. |
| GO:0010467 gene expression | IMP PMID:25083995 Canonical WNT signaling components in vascular development a... | MARK AS OVER ANNOTATED | Summary: The broad 'gene expression' parent is uninformative; beta-catenin's specific role is coactivation of TCF/LEF target gene transcription by Pol II. Reason: Overly broad parent superseded by specific Pol II transcription terms. Supporting Evidence: PMID:25083995 Canonical WNT signaling components in vascular development and barrier formation. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IDA PMID:16040629 Beta-catenin regulates differentiation of respiratory epithe... | KEEP AS NON CORE | Summary: An IDA call; beta-catenin represses certain Pol II targets in specific contexts, but this should be downgraded relative to its core activating coactivator role, not removed. Reason: Experimental (IDA); downgrade context-specific repression, do not REMOVE. Supporting Evidence: PMID:16040629 Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. |
| GO:0000165 MAPK cascade | IGI PMID:16478791 APC inhibits ERK pathway activation and cellular proliferati... | KEEP AS NON CORE | Summary: IGI evidence links beta-catenin to MAPK signaling, but this is signaling crosstalk and not a core function of the Wnt effector. Reason: Crosstalk pathway, not the gene's central Wnt/transcription function. Supporting Evidence: PMID:16478791 APC inhibits ERK pathway activation and cellular proliferation induced by RAS. |
| GO:0000578 embryonic axis specification | IDA PMID:9230313 The mouse Fused locus encodes Axin, an inhibitor of the Wnt ... | KEEP AS NON CORE | Summary: Beta-catenin establishes the primary embryonic axis (organizer formation) via nuclear Wnt/TCF activation (IDA); a hallmark downstream developmental outcome of its signaling role. Reason: downstream Wnt-driven embryonic axis formation Supporting Evidence: PMID:9230313 The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. |
| GO:0000902 cell morphogenesis | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | KEEP AS NON CORE | Summary: Beta-catenin shapes cell morphology via adherens-junction cytoskeletal linkage and Wnt transcription; a morphogenetic outcome of its dual structural/signaling roles. Reason: downstream of junction and Wnt roles Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0001501 skeletal system development | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling shapes skeletal patterning and ossification broadly; a high-level downstream organ-system phenotype. Reason: System-level skeletal development downstream of Wnt transcription. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0001569 branching involved in blood vessel morphogenesis | IMP PMID:12975353 The conditional inactivation of the beta-catenin gene in end... | KEEP AS NON CORE | Summary: Endothelial beta-catenin drives vessel branching through Wnt/TCF transcription and junction remodeling; a vascular morphogenetic outcome downstream of its dual role. Reason: downstream vascular branching from Wnt/junction roles Supporting Evidence: PMID:12975353 The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. |
| GO:0001569 branching involved in blood vessel morphogenesis | IMP PMID:19154719 Nrarp coordinates endothelial Notch and Wnt signaling to con... | KEEP AS NON CORE | Summary: Endothelial beta-catenin drives vessel branching through Wnt/TCF transcription and junction remodeling; a vascular morphogenetic outcome downstream of its dual role. Reason: downstream vascular branching from Wnt/junction roles Supporting Evidence: PMID:19154719 Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. |
| GO:0001570 vasculogenesis | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: De novo vessel formation requires Wnt/beta-catenin transcriptional control of endothelial precursors; a downstream developmental process. Reason: Vasculogenesis downstream of Wnt-driven endothelial transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0001649 osteoblast differentiation | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Wnt/beta-catenin is a master driver of osteoblast fate via Runx2/Osterix-linked targets; the differentiation outcome is downstream of that transcription. Reason: Osteoblastogenesis downstream of Wnt/beta-catenin transcriptional program. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0001658 branching involved in ureteric bud morphogenesis | IMP PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction durin... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling drives ureteric bud branching in kidney development; a renal morphogenetic outcome downstream of TCF target activation. Reason: downstream Wnt-driven renal branching morphogenesis Supporting Evidence: PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
| GO:0001701 in utero embryonic development | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin is essential for embryonic viability/development in utero via Wnt signaling and adhesion (IGI/IMP); a broad developmental outcome of its dual role, not core function. Reason: downstream of Wnt/junction roles in embryogenesis Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0001701 in utero embryonic development | IGI PMID:19204372 Both the RGS domain and the six C-terminal amino acids of mo... | KEEP AS NON CORE | Summary: Beta-catenin is essential for embryonic viability/development in utero via Wnt signaling and adhesion (IGI/IMP); a broad developmental outcome of its dual role, not core function. Reason: downstream of Wnt/junction roles in embryogenesis Supporting Evidence: PMID:19204372 Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. |
| GO:0001702 gastrulation with mouth forming second | IMP PMID:8582267 Lack of beta-catenin affects mouse development at gastrulati... | KEEP AS NON CORE | Summary: Beta-catenin drives deuterostome gastrulation/germ-layer movements via Wnt-driven organizer transcription; an early morphogenetic outcome downstream of signaling. Reason: downstream Wnt-driven gastrulation Supporting Evidence: PMID:8582267 Lack of beta-catenin affects mouse development at gastrulation. |
| GO:0001706 endoderm formation | IMP PMID:12194849 Formation of multiple hearts in mice following deletion of b... | KEEP AS NON CORE | Summary: Beta-catenin promotes definitive endoderm formation through nuclear Wnt/TCF activation; a germ-layer developmental outcome downstream of signaling. Reason: downstream Wnt-driven endoderm formation Supporting Evidence: PMID:12194849 Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. |
| GO:0001706 endoderm formation | IMP PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is e... | KEEP AS NON CORE | Summary: Beta-catenin promotes definitive endoderm formation through nuclear Wnt/TCF activation; a germ-layer developmental outcome downstream of signaling. Reason: downstream Wnt-driven endoderm formation Supporting Evidence: PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. |
| GO:0001708 cell fate specification | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Beta-catenin specifies cell fates via context-dependent Wnt target activation; a developmental specification outcome, not a proximal molecular mechanism. Reason: downstream Wnt-driven fate specification Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0001711 endodermal cell fate commitment | IMP PMID:12194849 Formation of multiple hearts in mice following deletion of b... | KEEP AS NON CORE | Summary: Beta-catenin commits cells to endodermal fate via Wnt target-gene activation; a cell-fate outcome downstream of its transcriptional effector role. Reason: downstream Wnt-driven endoderm commitment Supporting Evidence: PMID:12194849 Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. |
| GO:0001764 neuron migration | IGI PMID:21937711 ASPM regulates Wnt signaling pathway activity in the develop... | KEEP AS NON CORE | Summary: Beta-catenin affects neuronal migration through combined cadherin-adhesion and Wnt-transcriptional roles; a downstream CNS phenotype (genetic interaction). Reason: Neuron migration downstream of adhesion plus Wnt transcription. Supporting Evidence: PMID:21937711 ASPM regulates Wnt signaling pathway activity in the developing brain. |
| GO:0001822 kidney development | IMP PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction durin... | KEEP AS NON CORE | Summary: Beta-catenin drives nephrogenesis and tubule patterning via Wnt/TCF transcription; a renal organ-development outcome downstream of signaling. Reason: downstream Wnt-driven kidney development Supporting Evidence: PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
| GO:0001840 neural plate development | IDA PMID:22102609 Increased Ξ²-catenin activity in the anterior neural plate in... | KEEP AS NON CORE | Summary: Beta-catenin patterns the early neural plate through Wnt-dependent anteroposterior transcriptional control; an IDA developmental phenotype downstream of signaling. Reason: Neural plate patterning downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:22102609 Increased Ξ²-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. |
| GO:0001894 tissue homeostasis | IMP PMID:18635608 Tissue-specific requirements of beta-catenin in external gen... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling maintains adult tissue homeostasis (e.g. gut crypt renewal); a broad downstream organismal phenotype. Reason: Tissue homeostasis downstream of Wnt/beta-catenin self-renewal transcription. Supporting Evidence: PMID:18635608 Tissue-specific requirements of beta-catenin in external genitalia development. |
| GO:0001944 vasculature development | IMP PMID:19129494 Wnt/beta-catenin signaling is required for CNS, but not non-... | KEEP AS NON CORE | Summary: Whole-vasculature development depends on beta-catenin Wnt signaling in endothelium; a broad downstream organ-system phenotype. Reason: System-level vascular development downstream of Wnt/beta-catenin output. Supporting Evidence: PMID:19129494 Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. |
| GO:0002052 positive regulation of neuroblast proliferation | IGI PMID:21937711 ASPM regulates Wnt signaling pathway activity in the develop... | KEEP AS NON CORE | Summary: Beta-catenin positively drives neuroblast expansion through Wnt cell-cycle targets; a downstream neurodevelopmental proliferative role. Reason: Pro-neuroblast proliferation downstream of Wnt transcription. Supporting Evidence: PMID:21937711 ASPM regulates Wnt signaling pathway activity in the developing brain. |
| GO:0002053 positive regulation of mesenchymal cell proliferation | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin expands mesenchymal cells via Wnt mitogenic targets during organogenesis; a downstream proliferative phenotype. Reason: Mesenchymal proliferation downstream of Wnt mitogenic transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0002053 positive regulation of mesenchymal cell proliferation | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin expands mesenchymal cells via Wnt mitogenic targets during organogenesis; a downstream proliferative phenotype. Reason: Mesenchymal proliferation downstream of Wnt mitogenic transcription. Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0002062 chondrocyte differentiation | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Beta-catenin gates chondrocyte vs osteoblast fate via Wnt/TCF transcription; a skeletal cell-fate outcome downstream of its signaling effector role. Reason: downstream Wnt-driven chondrocyte fate Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0002062 chondrocyte differentiation | IGI PMID:16818445 Wnt9a signaling is required for joint integrity and regulati... | KEEP AS NON CORE | Summary: Beta-catenin gates chondrocyte vs osteoblast fate via Wnt/TCF transcription; a skeletal cell-fate outcome downstream of its signaling effector role. Reason: downstream Wnt-driven chondrocyte fate Supporting Evidence: PMID:16818445 Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. |
| GO:0002089 lens morphogenesis in camera-type eye | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | KEEP AS NON CORE | Summary: Beta-catenin (tightly regulated) shapes lens morphogenesis via Wnt transcription and epithelial junctions; an ocular morphogenetic outcome of its dual role. Reason: downstream of Wnt/junction roles in lens Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0003266 regulation of secondary heart field cardioblast proliferation | IDA PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... | KEEP AS NON CORE | Summary: Beta-catenin controls cardioblast proliferation in the second heart field via Wnt mitogenic targets; an IDA downstream cardiac phenotype. Reason: SHF cardioblast proliferation downstream of Wnt transcription. Supporting Evidence: PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. |
| GO:0003338 metanephros morphogenesis | IMP PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epith... | KEEP AS NON CORE | Summary: Beta-catenin shapes metanephric kidney morphogenesis via Wnt/TCF transcription; a renal morphogenetic outcome downstream of signaling. Reason: downstream Wnt-driven metanephros morphogenesis Supporting Evidence: PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. |
| GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | IDA PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction durin... | KEEP AS NON CORE | Summary: In kidney development beta-catenin tunes MET during nephrogenesis via Wnt-target transcription; the IDA is a specific developmental phenotype, not the proximal activity. Reason: Specific kidney MET-regulation phenotype downstream of beta-catenin Wnt transcriptional control of nephron epithelialization. Supporting Evidence: PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
| GO:0006351 DNA-templated transcription | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | MARK AS OVER ANNOTATED | Summary: beta-catenin is not part of the basal transcription machinery; it is a TCF/LEF coactivator. The bare 'DNA-templated transcription' parent is uninformative relative to its specific Pol II coactivator role. Reason: Generic transcription parent; its real role is captured by transcription coactivator / positive regulation of Pol II transcription. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream... | MODIFY | Summary: Essence correct but the directionless parent under-specifies beta-catenin's role; it functions specifically as a POSITIVE regulator/coactivator of Pol II transcription. Reason: Generic regulation parent; specialize to positive regulation of Pol II transcription. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. |
| GO:0006357 regulation of transcription by RNA polymerase II | IDA PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | MODIFY | Summary: Essence correct but the directionless parent under-specifies beta-catenin's role; it functions specifically as a POSITIVE regulator/coactivator of Pol II transcription. Reason: Generic regulation parent; specialize to positive regulation of Pol II transcription. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. |
| GO:0006357 regulation of transcription by RNA polymerase II | IMP PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling wit... | MODIFY | Summary: Essence correct but the directionless parent under-specifies beta-catenin's role; it functions specifically as a POSITIVE regulator/coactivator of Pol II transcription. Reason: Generic regulation parent; specialize to positive regulation of Pol II transcription. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. |
| GO:0006366 transcription by RNA polymerase II | IDA PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and... | MARK AS OVER ANNOTATED | Summary: beta-catenin is not a component of the Pol II transcription apparatus; this bare process term over-annotates its specific coactivator function. Reason: Uninformative process term; coactivator/positive-regulation terms preferred. Supporting Evidence: PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. |
| GO:0007160 cell-matrix adhesion | IMP PMID:15131783 Inducible Cre-mediated control of gene expression in the mur... | UNDECIDED | Summary: Cell-matrix adhesion is not a recognized beta-catenin function (it acts at cell-cell, not cell-ECM, junctions); the IMP basis cannot be verified here. Reason: Likely indirect/mislabeled, but IMP experimental annotation β do not REMOVE; flag for review. Supporting Evidence: PMID:15131783 Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. |
| GO:0007249 canonical NF-kappaB signal transduction | IMP PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | KEEP AS NON CORE | Summary: An IMP annotation; beta-catenin has documented crosstalk with NF-kappaB, but this is not its core function and the experimental call should be downgraded, not removed. Reason: Experimental (IMP) crosstalk annotation; downgrade rather than REMOVE. Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. |
| GO:0007268 chemical synaptic transmission | IMP PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin contributes to synaptic structure/vesicle organization at junctions affecting transmission; a neuronal outcome downstream of its adhesion role. Reason: downstream of synaptic adhesion organization Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0007398 ectoderm development | IMP PMID:8582267 Lack of beta-catenin affects mouse development at gastrulati... | KEEP AS NON CORE | Summary: Beta-catenin guides ectodermal development through Wnt-driven fate and morphogenesis; a germ-layer developmental outcome downstream of its transcriptional role. Reason: downstream Wnt-driven ectoderm development Supporting Evidence: PMID:8582267 Lack of beta-catenin affects mouse development at gastrulation. |
| GO:0007403 glial cell fate determination | IDA PMID:17706960 Persistent expression of stabilized beta-catenin delays matu... | KEEP AS NON CORE | Summary: Beta-catenin biases neural progenitors toward glial fate via Wnt/TCF transcription (IDA); a CNS cell-fate outcome downstream of signaling. Reason: downstream Wnt-driven glial fate determination Supporting Evidence: PMID:17706960 Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. |
| GO:0007405 neuroblast proliferation | IGI PMID:21937711 ASPM regulates Wnt signaling pathway activity in the develop... | KEEP AS NON CORE | Summary: Beta-catenin expands neuroblasts via Wnt mitogenic targets in genetic-interaction assays; a downstream CNS proliferative phenotype. Reason: Neuroblast proliferation downstream of Wnt mitogenic transcription. Supporting Evidence: PMID:21937711 ASPM regulates Wnt signaling pathway activity in the developing brain. |
| GO:0007507 heart development | IMP PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | KEEP AS NON CORE | Summary: Beta-catenin contributes broadly to cardiac development through Wnt-driven progenitor programs and junctions; an organ-development outcome of its dual role, not core function. Reason: downstream Wnt/junction-driven heart development Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. |
| GO:0008104 intracellular protein localization | IMP PMID:16621792 Membrane localization of adenomatous polyposis coli protein ... | KEEP AS NON CORE | Summary: Beta-catenin contributes to localizing partner proteins (e.g. junctional/synaptic cargo), a secondary process distinct from its own core roles. Reason: Peripheral process; IMP. Supporting Evidence: PMID:16621792 Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. |
| GO:0008283 cell population proliferation | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | MARK AS OVER ANNOTATED | Summary: Generic proliferation umbrella conveying nothing beta-catenin-specific; specific tissue-proliferation terms already capture Wnt-driven growth roles. Reason: vague proliferation umbrella adds no specificity Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0008283 cell population proliferation | IMP PMID:15131783 Inducible Cre-mediated control of gene expression in the mur... | MARK AS OVER ANNOTATED | Summary: Generic proliferation umbrella conveying nothing beta-catenin-specific; specific tissue-proliferation terms already capture Wnt-driven growth roles. Reason: vague proliferation umbrella adds no specificity Supporting Evidence: PMID:15131783 Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | KEEP AS NON CORE | Summary: Beta-catenin drives proliferation via Wnt mitogenic targets (Myc, cyclin D1); a key but downstream consequence of its transcriptional coactivation. Reason: Proliferation downstream of Wnt target genes Myc/CcnD1; non-core. Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin intersects FGFR signaling indirectly through Wnt/FGF developmental crosstalk; an experimental (IMP) phenotype downstream of signaling integration, not a core FGFR-pathway role. Reason: experimental; indirect FGF/Wnt crosstalk, downgrade not remove Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0009948 anterior/posterior axis specification | IMP PMID:10662781 Requirement for beta-catenin in anterior-posterior axis form... | KEEP AS NON CORE | Summary: Beta-catenin patterns the A/P axis through nuclear Wnt/TCF target activation in early embryo; an axial patterning outcome downstream of its transcriptional effector role. Reason: downstream Wnt-driven axial patterning Supporting Evidence: PMID:10662781 Requirement for beta-catenin in anterior-posterior axis formation in mice. |
| GO:0009950 dorsal/ventral axis specification | IMP PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP recepto... | KEEP AS NON CORE | Summary: Beta-catenin contributes to D/V axial specification through nuclear Wnt target activation; an axial patterning outcome downstream of its effector role. Reason: downstream Wnt-driven D/V axis specification Supporting Evidence: PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. |
| GO:0009953 dorsal/ventral pattern formation | IMP PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specific... | KEEP AS NON CORE | Summary: Beta-catenin participates in D/V pattern formation via Wnt/TCF transcriptional readout; a tissue-patterning outcome, not a proximal mechanism. Reason: downstream Wnt-driven D/V patterning Supporting Evidence: PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. |
| GO:0009954 proximal/distal pattern formation | IMP PMID:12885771 beta-Catenin is required for specification of proximal/dista... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling contributes to proximodistal patterning (e.g. limb/organ axes) via target-gene gradients; a downstream patterning phenotype. Reason: P/D patterning downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:12885771 beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. |
| GO:0010463 mesenchymal cell proliferation | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin promotes mesenchymal proliferation via Wnt target-gene activation; a connective-tissue growth outcome downstream of its transcriptional role. Reason: downstream Wnt-driven mesenchymal proliferation Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0010463 mesenchymal cell proliferation | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin promotes mesenchymal proliferation via Wnt target-gene activation; a connective-tissue growth outcome downstream of its transcriptional role. Reason: downstream Wnt-driven mesenchymal proliferation Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0010468 regulation of gene expression | IMP PMID:22102609 Increased Ξ²-catenin activity in the anterior neural plate in... | MARK AS OVER ANNOTATED | Summary: Very broad regulatory parent; beta-catenin's specific role is TCF/LEF coactivation regulating Pol II transcription of Wnt targets. Reason: Top-level generic parent; specific Pol II coactivation terms preferred. Supporting Evidence: PMID:22102609 Increased Ξ²-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. |
| GO:0010628 positive regulation of gene expression | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | MARK AS OVER ANNOTATED | Summary: Broad parent; beta-catenin's specific activating role is coactivation of TCF/LEF target gene transcription by Pol II, captured by more precise terms. Reason: Uninformative broad parent superseded by Pol II coactivation terms. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0010628 positive regulation of gene expression | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | MARK AS OVER ANNOTATED | Summary: Broad parent; beta-catenin's specific activating role is coactivation of TCF/LEF target gene transcription by Pol II, captured by more precise terms. Reason: Uninformative broad parent superseded by Pol II coactivation terms. Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | ISO GO_REF:0000008 | KEEP AS NON CORE | Summary: Nuclear beta-catenin drives EMT transcriptional programs (Snail/Twist targets) while loss of its junctional pool also promotes EMT; the process is downstream of both core roles. Reason: EMT is a transcriptional/adhesion downstream output, not beta-catenin's direct molecular function. |
| GO:0016331 morphogenesis of embryonic epithelium | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | KEEP AS NON CORE | Summary: Embryonic epithelial shaping requires Wnt/beta-catenin transcriptional output plus cadherin-junction adhesion, but the morphogenetic outcome is downstream of those proximal roles. Reason: Downstream tissue morphogenesis driven by beta-catenin's Wnt-transcription and adhesion roles, not a molecular function. Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0021819 layer formation in cerebral cortex | IMP PMID:20503375 Expression analysis of an evolutionarily conserved metalloph... | KEEP AS NON CORE | Summary: Beta-catenin influences cortical layering through Wnt/adhesion-dependent neural development, a tissue-specific developmental output. Reason: Developmental neuronal role; IMP, non-core. Supporting Evidence: PMID:20503375 Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. |
| GO:0022009 central nervous system vasculogenesis | IMP PMID:19023080 Canonical Wnt signaling regulates organ-specific assembly an... | KEEP AS NON CORE | Summary: Beta-catenin drives CNS vessel formation through endothelial Wnt/TCF transcription; a neurovascular developmental outcome, not core function. Reason: downstream Wnt-driven CNS vasculogenesis Supporting Evidence: PMID:19023080 Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. |
| GO:0022405 hair cycle process | IMP PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem c... | KEEP AS NON CORE | Summary: Beta-catenin drives hair-follicle cycling (anagen entry) via Wnt/TCF transcription in follicle stem cells; a skin-appendage outcome downstream of signaling. Reason: downstream Wnt-driven hair cycling Supporting Evidence: PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. |
| GO:0030097 hemopoiesis | IDA PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic ... | KEEP AS NON CORE | Summary: Beta-catenin modulates hematopoietic stem/progenitor activity via Wnt/TCF transcription (IDA); a blood-lineage developmental outcome downstream of signaling. Reason: downstream Wnt-driven hematopoiesis Supporting Evidence: PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic stem cells. |
| GO:0030154 cell differentiation | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | MARK AS OVER ANNOTATED | Summary: Top-level differentiation umbrella that says nothing specific about beta-catenin; its specific lineage-differentiation terms already capture the Wnt-driven roles. Reason: vague umbrella superseded by specific terms Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0030217 T cell differentiation | IMP PMID:14608382 Deletion of beta-catenin impairs T cell development. | KEEP AS NON CORE | Summary: Beta-catenin modulates thymocyte/T-cell differentiation through Wnt/TCF target-gene activation; an immune-lineage developmental outcome, not its proximal adhesion or transcriptional mechanism. Reason: downstream of Wnt/TCF program in lymphoid lineage Supporting Evidence: PMID:14608382 Deletion of beta-catenin impairs T cell development. |
| GO:0030316 osteoclast differentiation | IMP PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | KEEP AS NON CORE | Summary: Beta-catenin indirectly shapes osteoclast differentiation through osteoblast-derived RANKL/OPG balance; a downstream bone phenotype. Reason: Osteoclast differentiation downstream of Wnt-controlled RANKL/OPG output. Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0030324 lung development | IMP PMID:12885771 beta-Catenin is required for specification of proximal/dista... | KEEP AS NON CORE | Summary: Beta-catenin governs lung branching and cell-fate programs through Wnt transcription; a respiratory organ-development outcome downstream of signaling. Reason: downstream Wnt-driven lung development Supporting Evidence: PMID:12885771 beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. |
| GO:0048709 oligodendrocyte differentiation | IMP PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by ... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling modulates oligodendrocyte lineage progression; the differentiation process is downstream of its transcription. Reason: Glial differentiation downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. |
| GO:0051450 myoblast proliferation | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Wnt/beta-catenin signaling promotes myoblast expansion during myogenesis; this proliferative phenotype is a downstream consequence of its transcriptional output. Reason: Myogenic proliferation downstream of beta-catenin Wnt-target transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin drives lung airway branching through Wnt-driven epithelial-mesenchymal programs; a pulmonary morphogenetic outcome, not core function. Reason: downstream Wnt-driven lung branching Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0060487 lung epithelial cell differentiation | IMP PMID:16040629 Beta-catenin regulates differentiation of respiratory epithe... | KEEP AS NON CORE | Summary: Beta-catenin specifies lung epithelial cell types via Wnt/TCF transcription; an airway cell-fate outcome downstream of signaling. Reason: downstream Wnt-driven lung epithelial fate Supporting Evidence: PMID:16040629 Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. |
| GO:0060767 epithelial cell proliferation involved in prostate gland development | IMP PMID:12813461 Activation of beta-catenin in prostate epithelium induces hy... | KEEP AS NON CORE | Summary: Beta-catenin promotes prostate epithelial proliferation via Wnt target genes; a tissue-specific growth outcome downstream of its transcriptional role. Reason: downstream Wnt-driven prostate epithelial proliferation Supporting Evidence: PMID:12813461 Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. |
| GO:0072089 stem cell proliferation | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling sustains stem/progenitor self-renewal and proliferation across tissues; a key downstream consequence of its transcriptional program. Reason: Stem-cell proliferation/maintenance downstream of Wnt transcription. Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0097190 apoptotic signaling pathway | IMP PMID:15131783 Inducible Cre-mediated control of gene expression in the mur... | KEEP AS NON CORE | Summary: Beta-catenin influences apoptotic signaling indirectly via Wnt target genes (e.g. survival genes); a cell-fate consequence, not a direct apoptotic mechanism. Reason: indirect, downstream of Wnt survival-gene program Supporting Evidence: PMID:15131783 Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. |
| GO:0097190 apoptotic signaling pathway | IMP PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | KEEP AS NON CORE | Summary: Beta-catenin influences apoptotic signaling indirectly via Wnt target genes (e.g. survival genes); a cell-fate consequence, not a direct apoptotic mechanism. Reason: indirect, downstream of Wnt survival-gene program Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. |
| GO:0097190 apoptotic signaling pathway | IGI PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | KEEP AS NON CORE | Summary: Beta-catenin influences apoptotic signaling indirectly via Wnt target genes (e.g. survival genes); a cell-fate consequence, not a direct apoptotic mechanism. Reason: indirect, downstream of Wnt survival-gene program Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. |
| GO:0032212 positive regulation of telomere maintenance via telomerase | IMP PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: Beta-catenin up-regulates Tert transcription, boosting telomerase activity; a downstream transcriptional-target effect rather than a direct enzymatic role. Reason: Telomerase upregulation downstream of beta-catenin Tert transcription. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0001222 transcription corepressor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Binding to corepressors (e.g. via ICAT/Groucho crosstalk) modulates Wnt output, a regulatory rather than core coactivation interaction. Reason: Regulatory partner; electronic, non-core. |
| GO:0016358 dendrite development | IGI PMID:27713508 Conditional Knockout of Breast Carcinoma Amplified Sequence ... | KEEP AS NON CORE | Summary: Beta-catenin influences dendrite development through synaptic/adhesion roles in neurons, a tissue-specific developmental process. Reason: Neuronal developmental role; IGI, non-core. Supporting Evidence: PMID:27713508 Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via Ξ²-catenin. |
| GO:0001222 transcription corepressor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Binding to corepressors (e.g. via ICAT/Groucho crosstalk) modulates Wnt output, a regulatory rather than core coactivation interaction. Reason: Regulatory partner; electronic, non-core. |
| GO:0060856 establishment of blood-brain barrier | IMP PMID:25083995 Canonical WNT signaling components in vascular development a... | KEEP AS NON CORE | Summary: Beta-catenin (Wnt7-driven) establishes BBB endothelial properties via TCF transcription and junctions; a neurovascular barrier outcome downstream of its dual role. Reason: downstream Wnt/junction-driven BBB formation Supporting Evidence: PMID:25083995 Canonical WNT signaling components in vascular development and barrier formation. |
| GO:1990963 establishment of blood-retinal barrier | IMP PMID:25083995 Canonical WNT signaling components in vascular development a... | KEEP AS NON CORE | Summary: Beta-catenin (Norrin/Wnt-driven) establishes the blood-retinal barrier via TCF transcription and junctional integrity; a barrier-formation outcome downstream of its dual role. Reason: downstream Wnt/junction-driven BRB formation Supporting Evidence: PMID:25083995 Canonical WNT signaling components in vascular development and barrier formation. |
| GO:0001709 cell fate determination | IMP PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specific... | KEEP AS NON CORE | Summary: Beta-catenin biases cell-fate determination by activating Wnt/TCF lineage genes; a developmental fate outcome downstream of its transcriptional role. Reason: downstream Wnt-driven fate determination Supporting Evidence: PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. |
| GO:0003682 chromatin binding | IDA PMID:15024079 Brn-2 expression controls melanoma proliferation and is dire... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:15024079 Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. |
| GO:0003682 chromatin binding | IDA PMID:15778706 Wnt signalling induces maturation of Paneth cells in intesti... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:15778706 Wnt signalling induces maturation of Paneth cells in intestinal crypts. |
| GO:0003682 chromatin binding | IDA PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. |
| GO:0003682 chromatin binding | IDA PMID:16581771 CCN1/Cyr61 is regulated by the canonical Wnt signal and play... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:16581771 CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. |
| GO:0030154 cell differentiation | IMP PMID:15131783 Inducible Cre-mediated control of gene expression in the mur... | MARK AS OVER ANNOTATED | Summary: Top-level differentiation umbrella that says nothing specific about beta-catenin; its specific lineage-differentiation terms already capture the Wnt-driven roles. Reason: vague umbrella superseded by specific terms Supporting Evidence: PMID:15131783 Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. |
| GO:0030154 cell differentiation | IMP PMID:16192304 Beta-catenin is essential for pancreatic acinar but not isle... | MARK AS OVER ANNOTATED | Summary: Top-level differentiation umbrella that says nothing specific about beta-catenin; its specific lineage-differentiation terms already capture the Wnt-driven roles. Reason: vague umbrella superseded by specific terms Supporting Evidence: PMID:16192304 Beta-catenin is essential for pancreatic acinar but not islet development. |
| GO:0030324 lung development | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin governs lung branching and cell-fate programs through Wnt transcription; a respiratory organ-development outcome downstream of signaling. Reason: downstream Wnt-driven lung development Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0030539 male genitalia development | IMP PMID:19282366 Genetic interactions of the androgen and Wnt/beta-catenin pa... | KEEP AS NON CORE | Summary: Beta-catenin drives male external genital outgrowth/patterning via Wnt transcription; a urogenital developmental outcome downstream of signaling. Reason: downstream Wnt-driven male genitalia development Supporting Evidence: PMID:19282366 Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. |
| GO:0030856 regulation of epithelial cell differentiation | IMP PMID:12813461 Activation of beta-catenin in prostate epithelium induces hy... | KEEP AS NON CORE | Summary: Generic epithelial-differentiation regulation reflects beta-catenin's Wnt control of epithelial fate; a downstream umbrella process. Reason: Epithelial fate regulation downstream of Wnt transcription. Supporting Evidence: PMID:12813461 Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. |
| GO:0030858 positive regulation of epithelial cell differentiation | IMP PMID:16040629 Beta-catenin regulates differentiation of respiratory epithe... | KEEP AS NON CORE | Summary: Beta-catenin promotes epithelial differentiation in several tissues via Wnt-target transcription; a downstream lineage phenotype. Reason: Epithelial differentiation downstream of Wnt transcription. Supporting Evidence: PMID:16040629 Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. |
| GO:0030900 forebrain development | IMP PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specific... | KEEP AS NON CORE | Summary: Beta-catenin patterns forebrain via Wnt/TCF neural transcription and progenitor control; a CNS developmental outcome, not core function. Reason: downstream Wnt-driven forebrain development Supporting Evidence: PMID:15708565 Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. |
| GO:0031016 pancreas development | IMP PMID:16192304 Beta-catenin is essential for pancreatic acinar but not isle... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling is required for pancreatic growth and acinar development; a downstream organ-development phenotype. Reason: Pancreas development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:16192304 Beta-catenin is essential for pancreatic acinar but not islet development. |
| GO:0031069 hair follicle morphogenesis | IMP PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem c... | KEEP AS NON CORE | Summary: Beta-catenin is essential for hair-follicle morphogenesis through epidermal Wnt/TCF transcription; an ectodermal appendage outcome downstream of signaling. Reason: downstream Wnt-driven hair follicle morphogenesis Supporting Evidence: PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. |
| GO:0031069 hair follicle morphogenesis | IMP PMID:24309208 Wnt/Ξ²-catenin signaling in dermal condensates is required fo... | KEEP AS NON CORE | Summary: Beta-catenin is essential for hair-follicle morphogenesis through epidermal Wnt/TCF transcription; an ectodermal appendage outcome downstream of signaling. Reason: downstream Wnt-driven hair follicle morphogenesis Supporting Evidence: PMID:24309208 Wnt/Ξ²-catenin signaling in dermal condensates is required for hair follicle formation. |
| GO:0031641 regulation of myelination | IMP PMID:19515974 Dysregulation of the Wnt pathway inhibits timely myelination... | KEEP AS NON CORE | Summary: Beta-catenin modulates myelination via Wnt-dependent control of oligodendrocyte maturation; a downstream glial/CNS phenotype. Reason: Myelination control downstream of Wnt oligodendrocyte transcription. Supporting Evidence: PMID:19515974 Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. |
| GO:0032331 negative regulation of chondrocyte differentiation | IGI PMID:16818445 Wnt9a signaling is required for joint integrity and regulati... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling biases skeletal progenitors away from chondrogenesis toward osteogenesis; a genetic-interaction downstream skeletal phenotype. Reason: Chondrocyte suppression downstream of Wnt fate-switch transcription. Supporting Evidence: PMID:16818445 Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. |
| GO:0033077 T cell differentiation in thymus | IMP PMID:16025118 Loss of adenomatous polyposis coli gene function disrupts th... | KEEP AS NON CORE | Summary: Thymic T-cell differentiation requires Wnt/beta-catenin transcriptional signaling; a tissue-specific lymphoid maturation phenotype downstream of TCF co-activation. Reason: tissue-specific downstream Wnt output in thymus Supporting Evidence: PMID:16025118 Loss of adenomatous polyposis coli gene function disrupts thymic development. |
| GO:0034332 adherens junction organization | IMP PMID:19129494 Wnt/beta-catenin signaling is required for CNS, but not non-... | ACCEPT | Summary: Beta-catenin organizes adherens junctions through the cadherin-catenin complex; loss perturbs junction integrity. Reason: Core adhesion process; IMP-supported. Supporting Evidence: PMID:19129494 Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. |
| GO:0035050 embryonic heart tube development | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin contributes to heart-tube formation via Wnt-driven cardiac progenitor programs; a cardiac developmental outcome, not core function. Reason: downstream Wnt-driven heart tube development Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0035112 genitalia morphogenesis | IMP PMID:18635608 Tissue-specific requirements of beta-catenin in external gen... | KEEP AS NON CORE | Summary: Beta-catenin shapes external genitalia via Wnt-driven outgrowth and patterning; a urogenital morphogenetic outcome downstream of transcription. Reason: downstream Wnt-driven genital morphogenesis Supporting Evidence: PMID:18635608 Tissue-specific requirements of beta-catenin in external genitalia development. |
| GO:0035115 embryonic forelimb morphogenesis | IDA PMID:15371327 Wnt/beta-catenin signaling is sufficient and necessary for s... | KEEP AS NON CORE | Summary: Beta-catenin drives forelimb outgrowth/patterning through Wnt-driven AER maintenance (IDA); a limb developmental outcome downstream of its signaling role. Reason: downstream Wnt-driven forelimb morphogenesis Supporting Evidence: PMID:15371327 Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. |
| GO:0035116 embryonic hindlimb morphogenesis | IMP PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP recepto... | KEEP AS NON CORE | Summary: Beta-catenin drives hindlimb outgrowth/patterning via Wnt signaling in limb mesenchyme/AER; a limb morphogenetic outcome downstream of transcription. Reason: downstream Wnt-driven hindlimb morphogenesis Supporting Evidence: PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. |
| GO:0035116 embryonic hindlimb morphogenesis | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin drives hindlimb outgrowth/patterning via Wnt signaling in limb mesenchyme/AER; a limb morphogenetic outcome downstream of transcription. Reason: downstream Wnt-driven hindlimb morphogenesis Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0042127 regulation of cell population proliferation | IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream... | KEEP AS NON CORE | Summary: Generic proliferation regulation reflects beta-catenin's Wnt mitogenic transcriptional program; downstream and non-specific. Reason: Umbrella proliferation regulation downstream of Wnt transcription. Supporting Evidence: PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. |
| GO:0042127 regulation of cell population proliferation | IMP PMID:17055474 The stabilization of beta-catenin leads to impaired primordi... | KEEP AS NON CORE | Summary: Generic proliferation regulation reflects beta-catenin's Wnt mitogenic transcriptional program; downstream and non-specific. Reason: Umbrella proliferation regulation downstream of Wnt transcription. Supporting Evidence: PMID:17055474 The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. |
| GO:0042127 regulation of cell population proliferation | IMP PMID:18635608 Tissue-specific requirements of beta-catenin in external gen... | KEEP AS NON CORE | Summary: Generic proliferation regulation reflects beta-catenin's Wnt mitogenic transcriptional program; downstream and non-specific. Reason: Umbrella proliferation regulation downstream of Wnt transcription. Supporting Evidence: PMID:18635608 Tissue-specific requirements of beta-catenin in external genitalia development. |
| GO:0042129 regulation of T cell proliferation | IMP PMID:14608382 Deletion of beta-catenin impairs T cell development. | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling modulates T-cell expansion during lymphopoiesis; a downstream immune-development phenotype. Reason: T-cell proliferation control downstream of Wnt transcription. Supporting Evidence: PMID:14608382 Deletion of beta-catenin impairs T cell development. |
| GO:0042475 odontogenesis of dentin-containing tooth | IMP PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling is essential for tooth morphogenesis and dentinogenesis; a downstream organ-development phenotype. Reason: Tooth development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0042733 embryonic digit morphogenesis | IMP PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP recepto... | KEEP AS NON CORE | Summary: Beta-catenin shapes digit formation in the limb through Wnt-driven AER and mesenchymal programs; a limb morphogenetic outcome downstream of signaling. Reason: downstream Wnt-driven digit morphogenesis Supporting Evidence: PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. |
| GO:0042733 embryonic digit morphogenesis | IMP PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling wit... | KEEP AS NON CORE | Summary: Beta-catenin shapes digit formation in the limb through Wnt-driven AER and mesenchymal programs; a limb morphogenetic outcome downstream of signaling. Reason: downstream Wnt-driven digit morphogenesis Supporting Evidence: PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. |
| GO:0042733 embryonic digit morphogenesis | IGI PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling wit... | KEEP AS NON CORE | Summary: Beta-catenin shapes digit formation in the limb through Wnt-driven AER and mesenchymal programs; a limb morphogenetic outcome downstream of signaling. Reason: downstream Wnt-driven digit morphogenesis Supporting Evidence: PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. |
| GO:0042981 regulation of apoptotic process | IMP PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling wit... | KEEP AS NON CORE | Summary: Generic apoptosis regulation reflects beta-catenin's transcriptional control of survival/death genes; a downstream, non-specific regulatory role. Reason: Umbrella survival/death regulation downstream of Wnt transcription. Supporting Evidence: PMID:20043884 Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. |
| GO:0043410 positive regulation of MAPK cascade | IGI PMID:16478791 APC inhibits ERK pathway activation and cellular proliferati... | KEEP AS NON CORE | Summary: IGI-supported genetic interaction with MAPK signaling; a crosstalk effect rather than beta-catenin's core Wnt/transcription function. Reason: Crosstalk regulatory effect; non-core (experimental IGI, not removed). Supporting Evidence: PMID:16478791 APC inhibits ERK pathway activation and cellular proliferation induced by RAS. |
| GO:0043524 negative regulation of neuron apoptotic process | IGI PMID:22956852 Integration of Ξ²-catenin, sirtuin, and FOXO signaling protec... | KEEP AS NON CORE | Summary: Beta-catenin protects neurons from apoptosis in genetic-interaction assays, consistent with Wnt-driven survival transcription; a neuron-specific downstream phenotype. Reason: Neuronal survival downstream of Wnt/beta-catenin transcriptional targets. Supporting Evidence: PMID:22956852 Integration of Ξ²-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. |
| GO:0043588 skin development | IMP PMID:19718027 Tcf3 and Tcf4 are essential for long-term homeostasis of ski... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling governs epidermal/appendage development; a downstream organ-system phenotype combining adhesion and transcription roles. Reason: Skin development downstream of Wnt transcription and adhesion. Supporting Evidence: PMID:19718027 Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. |
| GO:0045453 bone resorption | IMP PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | KEEP AS NON CORE | Summary: Beta-catenin shifts osteoblast/osteoclast balance (e.g. OPG induction) via Wnt/TCF transcription, regulating resorption; a skeletal-remodeling outcome, not core function. Reason: downstream of Wnt-driven osteo-transcriptional balance Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0045453 bone resorption | IGI PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | KEEP AS NON CORE | Summary: Beta-catenin shifts osteoblast/osteoclast balance (e.g. OPG induction) via Wnt/TCF transcription, regulating resorption; a skeletal-remodeling outcome, not core function. Reason: downstream of Wnt-driven osteo-transcriptional balance Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0045595 regulation of cell differentiation | IDA PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic ... | KEEP AS NON CORE | Summary: IDA-level generic differentiation regulation summarizes beta-catenin's transcriptional control of many fate decisions; a downstream umbrella process. Reason: Broad differentiation control downstream of Wnt transcription. Supporting Evidence: PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic stem cells. |
| GO:0045596 negative regulation of cell differentiation | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Beta-catenin can hold progenitors undifferentiated via Wnt-target transcription (stemness genes); a broad downstream differentiation-blocking phenotype. Reason: Differentiation suppression downstream of Wnt stemness-gene transcription. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0045596 negative regulation of cell differentiation | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | KEEP AS NON CORE | Summary: Beta-catenin can hold progenitors undifferentiated via Wnt-target transcription (stemness genes); a broad downstream differentiation-blocking phenotype. Reason: Differentiation suppression downstream of Wnt stemness-gene transcription. Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:0045603 positive regulation of endothelial cell differentiation | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Wnt/beta-catenin transcription supports endothelial cell fate during vascular development; the differentiation outcome is downstream. Reason: Endothelial differentiation downstream of Wnt-target transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0045667 regulation of osteoblast differentiation | IMP PMID:15576404 Sequential roles of Hedgehog and Wnt signaling in osteoblast... | KEEP AS NON CORE | Summary: Generic osteoblast-differentiation regulation summarizes beta-catenin's Wnt control of bone-forming cell fate; downstream and somewhat redundant. Reason: Osteoblast fate regulation downstream of Wnt transcription. Supporting Evidence: PMID:15576404 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. |
| GO:0045667 regulation of osteoblast differentiation | IMP PMID:15802266 Essential role of beta-catenin in postnatal bone acquisition... | KEEP AS NON CORE | Summary: Generic osteoblast-differentiation regulation summarizes beta-catenin's Wnt control of bone-forming cell fate; downstream and somewhat redundant. Reason: Osteoblast fate regulation downstream of Wnt transcription. Supporting Evidence: PMID:15802266 Essential role of beta-catenin in postnatal bone acquisition. |
| GO:0045669 positive regulation of osteoblast differentiation | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: Beta-catenin promotes osteoblast differentiation by activating osteogenic Wnt targets; a downstream, lineage-specific developmental role. Reason: Pro-osteoblast effect downstream of Wnt osteogenic transcription. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0045670 regulation of osteoclast differentiation | IMP PMID:15802266 Essential role of beta-catenin in postnatal bone acquisition... | KEEP AS NON CORE | Summary: Beta-catenin regulates osteoclastogenesis indirectly via osteoblast RANKL/OPG transcription; a downstream bone-remodeling control. Reason: Osteoclast regulation downstream of Wnt-driven osteoblast signaling. Supporting Evidence: PMID:15802266 Essential role of beta-catenin in postnatal bone acquisition. |
| GO:0045671 negative regulation of osteoclast differentiation | IMP PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | KEEP AS NON CORE | Summary: Osteoblast-lineage beta-catenin Wnt signaling raises OPG to restrain osteoclastogenesis; a downstream bone-remodeling phenotype. Reason: Osteoclast suppression downstream of Wnt-driven OPG transcription. Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin Wnt output can up-regulate FGF ligands/receptors, amplifying FGFR signaling; a downstream signaling-crosstalk phenotype. Reason: FGFR pathway boost downstream of Wnt-target transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin Wnt output can up-regulate FGF ligands/receptors, amplifying FGFR signaling; a downstream signaling-crosstalk phenotype. Reason: FGFR pathway boost downstream of Wnt-target transcription. Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0045892 negative regulation of DNA-templated transcription | IDA PMID:12551949 Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-de... | KEEP AS NON CORE | Summary: beta-catenin can repress specific targets (e.g. via SOX9/TCF competition or unliganded-TCF contexts), but its core, defining transcriptional role is positive coactivation of TCF/LEF targets. Reason: Context-dependent repression; secondary to its activating role. Supporting Evidence: PMID:12551949 Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. |
| GO:0045892 negative regulation of DNA-templated transcription | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | KEEP AS NON CORE | Summary: beta-catenin can repress specific targets (e.g. via SOX9/TCF competition or unliganded-TCF contexts), but its core, defining transcriptional role is positive coactivation of TCF/LEF targets. Reason: Context-dependent repression; secondary to its activating role. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:10631168 Hippocampus development and generation of dentate gyrus gran... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:10631168 Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:12551949 Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-de... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:12551949 Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 exp... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:17767158 Modulation of morphogenesis by noncanonical Wnt signaling re... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:17767158 Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:19056892 A functional link between Wnt signaling and SKP2-independent... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:19056892 A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:15024079 Brn-2 expression controls melanoma proliferation and is dire... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:15024079 Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:15729346 Pax3 functions at a nodal point in melanocyte stem cell diff... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:15729346 Pax3 functions at a nodal point in melanocyte stem cell differentiation. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:15778706 Wnt signalling induces maturation of Paneth cells in intesti... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:15778706 Wnt signalling induces maturation of Paneth cells in intestinal crypts. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:15907834 Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:20159597 Characterization and in vivo pharmacological rescue of a Wnt... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:20159597 Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:20627076 The Wnt/beta-catenin pathway modulates vascular remodeling a... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:20627076 The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:21750544 The Wnt3a/Ξ²-catenin target gene Mesogenin1 controls the segm... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:21750544 The Wnt3a/Ξ²-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. |
| GO:0048469 cell maturation | IMP PMID:15576404 Sequential roles of Hedgehog and Wnt signaling in osteoblast... | KEEP AS NON CORE | Summary: Beta-catenin supports terminal cell maturation in several lineages through Wnt transcriptional output; a differentiation-completion outcome (IDA/IMP), not core function. Reason: downstream maturation of Wnt-target lineages Supporting Evidence: PMID:15576404 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. |
| GO:0048469 cell maturation | IDA PMID:17706960 Persistent expression of stabilized beta-catenin delays matu... | KEEP AS NON CORE | Summary: Beta-catenin supports terminal cell maturation in several lineages through Wnt transcriptional output; a differentiation-completion outcome (IDA/IMP), not core function. Reason: downstream maturation of Wnt-target lineages Supporting Evidence: PMID:17706960 Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. |
| GO:0048489 synaptic vesicle transport | IMP PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin's cadherin scaffolding influences synaptic vesicle localization/transport; a downstream adhesion-linked synaptic phenotype. Reason: Vesicle transport downstream of cadherin-adhesion scaffolding role. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0048513 animal organ development | IMP PMID:18635608 Tissue-specific requirements of beta-catenin in external gen... | MARK AS OVER ANNOTATED | Summary: Generic organ-development umbrella that conveys nothing specific about beta-catenin; the many specific organ terms already capture its Wnt-driven roles. Reason: vague high-level umbrella adds no specificity Supporting Evidence: PMID:18635608 Tissue-specific requirements of beta-catenin in external genitalia development. |
| GO:0048538 thymus development | IMP PMID:16025118 Loss of adenomatous polyposis coli gene function disrupts th... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling supports thymic epithelial/lymphoid development; a downstream organ-development phenotype. Reason: Thymus development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:16025118 Loss of adenomatous polyposis coli gene function disrupts thymic development. |
| GO:0048599 oocyte development | IGI PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | KEEP AS NON CORE | Summary: Beta-catenin influences oogenesis in genetic-interaction assays, likely via Wnt-transcriptional control of follicular signaling; a downstream germ-cell phenotype. Reason: Oocyte development downstream of Wnt transcription; non-core. Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. |
| GO:0048617 embryonic foregut morphogenesis | IMP PMID:18692041 Bmp4 is required for tracheal formation: a novel mouse model... | KEEP AS NON CORE | Summary: Beta-catenin patterns foregut endoderm via Wnt/TCF transcription enabling organ budding; a gut morphogenetic outcome, not core function. Reason: downstream Wnt-driven foregut morphogenesis Supporting Evidence: PMID:18692041 Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. |
| GO:0048715 negative regulation of oligodendrocyte differentiation | IMP PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by ... | KEEP AS NON CORE | Summary: Wnt/beta-catenin inhibits oligodendrocyte maturation (e.g. via Id targets); a downstream glial-fate phenotype. Reason: Oligodendrocyte block downstream of Wnt transcriptional targets. Supporting Evidence: PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. |
| GO:0050808 synapse organization | IMP PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin organizes synapses through cadherin adhesion, a neuron-specific developmental/structural role. Reason: Neuronal process; IMP, non-core. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0051145 smooth muscle cell differentiation | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | KEEP AS NON CORE | Summary: Beta-catenin contributes to smooth muscle fate specification via Wnt-driven transcription; the differentiation outcome is downstream of that program. Reason: Smooth-muscle fate is downstream transcriptional output, not core MF. Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0060066 oviduct development | IMP PMID:17532316 Essential roles of mesenchyme-derived beta-catenin in mouse ... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling patterns Mullerian-duct-derived oviduct; a downstream reproductive-organ development phenotype. Reason: Oviduct development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:17532316 Essential roles of mesenchyme-derived beta-catenin in mouse MΓΌllerian duct morphogenesis. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic ... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic stem cells. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:15781477 Sox2 induction by FGF and FGFR2 activating mutations inhibit... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:15781477 Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IGI PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IGI PMID:16818445 Wnt9a signaling is required for joint integrity and regulati... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:16818445 Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epith... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IGI PMID:19686689 Wnt2/2b and beta-catenin signaling are necessary and suffici... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:19686689 Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IGI PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:31222549 The Shisa3 knockout mouse exhibits normal bone phenotype. | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:31222549 The Shisa3 knockout mouse exhibits normal bone phenotype. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060173 limb development | IMP PMID:12569130 Ectodermal Wnt3/beta-catenin signaling is required for the e... | KEEP AS NON CORE | Summary: Beta-catenin is required for limb-bud outgrowth via Wnt-driven AER maintenance; a limb organ-development outcome downstream of signaling. Reason: downstream Wnt-driven limb development Supporting Evidence: PMID:12569130 Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. |
| GO:0060439 trachea morphogenesis | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin shapes tracheal morphology during foregut development via Wnt targets; a downstream organ-morphogenesis phenotype. Reason: Trachea morphogenesis downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0060439 trachea morphogenesis | IMP PMID:18692041 Bmp4 is required for tracheal formation: a novel mouse model... | KEEP AS NON CORE | Summary: Beta-catenin shapes tracheal morphology during foregut development via Wnt targets; a downstream organ-morphogenesis phenotype. Reason: Trachea morphogenesis downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:18692041 Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. |
| GO:0060440 trachea formation | IMP PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mou... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling is required for tracheal tube formation; a downstream respiratory-organ morphogenesis phenotype. Reason: Trachea formation downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mouse foregut. |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin drives lung airway branching through Wnt-driven epithelial-mesenchymal programs; a pulmonary morphogenetic outcome, not core function. Reason: downstream Wnt-driven lung branching Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0060479 lung cell differentiation | IMP PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mou... | KEEP AS NON CORE | Summary: Beta-catenin drives pulmonary cell-type differentiation via Wnt/TCF transcription; a lung cell-fate outcome downstream of signaling. Reason: downstream Wnt-driven lung cell differentiation Supporting Evidence: PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mouse foregut. |
| GO:0060484 lung-associated mesenchyme development | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin supports pulmonary mesenchyme development via Wnt-driven transcription enabling epithelial-mesenchymal crosstalk; a tissue developmental outcome. Reason: downstream Wnt-driven lung mesenchyme development Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0060492 lung induction | IMP PMID:19686689 Wnt2/2b and beta-catenin signaling are necessary and suffici... | KEEP AS NON CORE | Summary: Beta-catenin participates in initial lung specification from foregut endoderm via Wnt transcription; an early organ-induction outcome downstream of signaling. Reason: downstream Wnt-driven lung induction Supporting Evidence: PMID:19686689 Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. |
| GO:0060492 lung induction | IMP PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mou... | KEEP AS NON CORE | Summary: Beta-catenin participates in initial lung specification from foregut endoderm via Wnt transcription; an early organ-induction outcome downstream of signaling. Reason: downstream Wnt-driven lung induction Supporting Evidence: PMID:19805295 beta-Catenin promotes respiratory progenitor identity in mouse foregut. |
| GO:0060742 epithelial cell differentiation involved in prostate gland development | IMP PMID:12813461 Activation of beta-catenin in prostate epithelium induces hy... | KEEP AS NON CORE | Summary: Beta-catenin drives prostate epithelial differentiation via Wnt/TCF transcription; a tissue-specific cell-fate outcome downstream of signaling. Reason: downstream Wnt-driven prostate epithelial fate Supporting Evidence: PMID:12813461 Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. |
| GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development | IMP PMID:12813461 Activation of beta-catenin in prostate epithelium induces hy... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling drives prostate epithelial proliferation during gland development; a downstream organ-specific phenotype. Reason: Prostate epithelial proliferation downstream of Wnt transcription. Supporting Evidence: PMID:12813461 Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. |
| GO:0060789 hair follicle placode formation | IMP PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem c... | KEEP AS NON CORE | Summary: Beta-catenin initiates hair placodes via Wnt/TCF transcription in epidermis (IGI/IMP); an early skin-appendage outcome downstream of signaling. Reason: downstream Wnt-driven hair placode initiation Supporting Evidence: PMID:11371349 beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. |
| GO:0060789 hair follicle placode formation | IGI PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | KEEP AS NON CORE | Summary: Beta-catenin initiates hair placodes via Wnt/TCF transcription in epidermis (IGI/IMP); an early skin-appendage outcome downstream of signaling. Reason: downstream Wnt-driven hair placode initiation Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. |
| GO:0060916 mesenchymal cell proliferation involved in lung development | IMP PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla developme... | KEEP AS NON CORE | Summary: Beta-catenin sustains lung mesenchyme proliferation via Wnt transcription supporting branching; a tissue-specific growth outcome downstream of signaling. Reason: downstream Wnt-driven lung mesenchymal proliferation Supporting Evidence: PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla development. |
| GO:0060916 mesenchymal cell proliferation involved in lung development | IMP PMID:18231602 Formation and differentiation of multiple mesenchymal lineag... | KEEP AS NON CORE | Summary: Beta-catenin sustains lung mesenchyme proliferation via Wnt transcription supporting branching; a tissue-specific growth outcome downstream of signaling. Reason: downstream Wnt-driven lung mesenchymal proliferation Supporting Evidence: PMID:18231602 Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. |
| GO:0061047 positive regulation of branching involved in lung morphogenesis | IMP PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme ... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling promotes airway branching during lung morphogenesis; a downstream organ-morphogenesis phenotype. Reason: Lung branching downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:18533146 An FGF-WNT gene regulatory network controls lung mesenchyme development. |
| GO:0061198 fungiform papilla formation | IMP PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla developme... | KEEP AS NON CORE | Summary: Beta-catenin drives fungiform (taste) papilla formation through Wnt-driven placode programs; an ectodermal appendage outcome downstream of signaling. Reason: downstream Wnt-driven papilla placode formation Supporting Evidence: PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla development. |
| GO:0072033 renal vesicle formation | IMP PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction durin... | KEEP AS NON CORE | Summary: Wnt/beta-catenin induces renal vesicles from cap mesenchyme, the first epithelial nephron unit; a downstream renal morphogenesis step. Reason: Renal vesicle induction downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
| GO:0072053 renal inner medulla development | IMP PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epith... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling contributes to inner medullary patterning during kidney development; a downstream regional renal phenotype. Reason: Inner-medulla development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. |
| GO:0072054 renal outer medulla development | IMP PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epith... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling shapes outer medullary kidney architecture; a downstream regional renal-development phenotype. Reason: Outer-medulla development downstream of Wnt transcription. Supporting Evidence: PMID:19060336 A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. |
| GO:0072079 nephron tubule formation | IMP PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction durin... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling drives mesenchyme-to-nephron-tubule conversion; a downstream renal morphogenesis phenotype. Reason: Nephron tubule formation downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:17537789 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
| GO:0098609 cell-cell adhesion | IMP PMID:16102745 The duality of beta-catenin function: a requirement in lens ... | ACCEPT | Summary: Beta-catenin is essential for cadherin-based cell-cell adhesion, anchoring the adhesion complex to the cytoskeleton. Reason: Core adhesion process; IBA/IMP-supported. Supporting Evidence: PMID:16102745 The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. |
| GO:2000017 positive regulation of determination of dorsal identity | IDA PMID:18316368 Protein encoded by the Axin(Fu) allele effectively down-regu... | KEEP AS NON CORE | Summary: Nuclear beta-catenin specifies dorsal/organizer identity in early embryos via Wnt-target transcription; an IDA axis-patterning phenotype downstream of signaling. Reason: Dorsal-axis specification downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:18316368 Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. |
| GO:2001234 negative regulation of apoptotic signaling pathway | IMP PMID:15131783 Inducible Cre-mediated control of gene expression in the mur... | KEEP AS NON CORE | Summary: Genetic evidence links beta-catenin to dampening apoptotic signaling, plausibly via Wnt survival-gene transcription; a downstream regulatory phenotype. Reason: Downstream survival-signaling modulation via Wnt transcription. Supporting Evidence: PMID:15131783 Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. |
| GO:2001234 negative regulation of apoptotic signaling pathway | IMP PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | KEEP AS NON CORE | Summary: Genetic evidence links beta-catenin to dampening apoptotic signaling, plausibly via Wnt survival-gene transcription; a downstream regulatory phenotype. Reason: Downstream survival-signaling modulation via Wnt transcription. Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. |
| GO:2001234 negative regulation of apoptotic signaling pathway | IGI PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell surviva... | KEEP AS NON CORE | Summary: Genetic evidence links beta-catenin to dampening apoptotic signaling, plausibly via Wnt survival-gene transcription; a downstream regulatory phenotype. Reason: Downstream survival-signaling modulation via Wnt transcription. Supporting Evidence: PMID:20454446 WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. |
| GO:0003676 nucleic acid binding | EXP PMID:21075118 Biochemical and structural characterization of Ξ²-catenin int... | MODIFY | Summary: Beta-catenin does not bind DNA sequence-specifically; its genuine nucleic-acid-associated role is chromatin association within TCF/LEF complexes. Reason: Over-general/likely indirect; replace with chromatin binding which it genuinely does. Proposed replacements: chromatin binding Supporting Evidence: PMID:21075118 Biochemical and structural characterization of Ξ²-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. |
| GO:0001221 transcription coregulator binding | IPI PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: Binding to transcription coregulators broadens beta-catenin's coactivator interactions; specific TF/coactivator terms more directly capture the core Wnt role. Reason: Generic-ish nuclear MF; IPI, supportive. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. |
| GO:0098609 cell-cell adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin is essential for cadherin-based cell-cell adhesion, anchoring the adhesion complex to the cytoskeleton. Reason: Core adhesion process; IBA/IMP-supported. |
| GO:0045296 cadherin binding | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0016922 nuclear receptor binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Beta-catenin coactivates several nuclear receptors (e.g. NR5A2, AR/ER), broadening its transcriptional crosstalk beyond the core TCF/LEF axis. Reason: Crosstalk coactivation; non-core relative to TCF. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. |
| GO:0019903 protein phosphatase binding | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Protein-phosphatase binding (e.g. PTPN6/PTPRJ) regulates tyrosine-phosphorylation of junctional beta-catenin, a regulatory interaction. Reason: Regulatory partner; IBA/IPI, non-core. |
| GO:0045294 alpha-catenin binding | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. |
| GO:0005912 adherens junction | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0016342 catenin complex | IBA GO_REF:0000033 | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). |
| GO:0003713 transcription coactivator activity | IBA GO_REF:0000033 | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0000922 spindle pole | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: A mitotic spindle-pole pool (via NEK2) reflects a centrosome-related moonlighting localization, distinct from core adhesion/Wnt roles. Reason: Secondary localization; IEA, non-core. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. |
| GO:0005813 centrosome | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal pool acting in centrosome cohesion/separation, distinct from its core adhesion and Wnt roles. Reason: Secondary localization; IDA but non-core moonlighting. |
| GO:0005856 cytoskeleton | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Cytoskeleton localization reflects indirect cortical actin association via the cadherin-catenin complex; the specific junctional terms are more informative. Reason: Over-general CC parent; electronic. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005912 adherens junction | IEA GO_REF:0000120 | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0007155 cell adhesion | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Generic cell adhesion is subsumed by the more specific cadherin-mediated cell-cell adhesion terms that capture beta-catenin's actual mechanism. Reason: Over-general parent; electronic; specific child preferred. |
| GO:0007399 nervous system development | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Pure-IEA, system-wide nervous-system development is too high-level to be informative; beta-catenin's specific CNS roles are captured by finer child terms. Reason: Vague IEA umbrella adding nothing over specific neural terms; over-annotation. |
| GO:0016020 membrane | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. |
| GO:0016055 Wnt signaling pathway | IEA GO_REF:0000043 | MODIFY | Summary: beta-catenin acts specifically in the CANONICAL (beta-catenin-dependent) Wnt branch, not the non-canonical branches. The generic parent should be specialized. Reason: IEA generic parent; specific canonical child available and well supported. Proposed replacements: canonical Wnt signaling pathway |
| GO:0045202 synapse | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Synaptic localization supports cadherin-based synaptic adhesion in neurons, a tissue-specific pool. Reason: Synapse localization; IDA/IEA, non-core. |
| GO:0045216 cell-cell junction organization | IEA GO_REF:0000117 | ACCEPT | Summary: Beta-catenin contributes to organizing cell-cell junctions through assembly of the cadherin-catenin adhesion complex. Reason: Core adhesion process; consistent with junction roles. |
| GO:0045296 cadherin binding | IEA GO_REF:0000120 | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0070161 anchoring junction | IEA GO_REF:0000044 | ACCEPT | Summary: Beta-catenin localizes to anchoring junctions (adherens junctions), consistent with its cadherin-catenin structural role. Reason: Core localization parent of adherens junction. |
| GO:0005515 protein binding | IPI PMID:10481074 A GSK3-binding peptide from FRAT1 selectively inhibits the G... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:10481074 A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. |
| GO:0005515 protein binding | IPI PMID:10873669 Identification of a novel beta-catenin-interacting protein. | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:10873669 Identification of a novel beta-catenin-interacting protein. |
| GO:0005515 protein binding | IPI PMID:10882138 Structure of the dimerization and beta-catenin-binding regio... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:10882138 Structure of the dimerization and beta-catenin-binding region of alpha-catenin. |
| GO:0005515 protein binding | IPI PMID:11348595 The structure of the beta-catenin/E-cadherin complex and the... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:11348595 The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. |
| GO:0005515 protein binding | IPI PMID:12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcr... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. |
| GO:0005515 protein binding | IPI PMID:12421363 Axin negatively affects tau phosphorylation by glycogen synt... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12421363 Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta. |
| GO:0005515 protein binding | IPI PMID:12874278 The PDZ protein tax-interacting protein-1 inhibits beta-cate... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12874278 The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. |
| GO:0005515 protein binding | IPI PMID:14691142 alpha3beta1 integrin-CD151, a component of the cadherin-cate... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:14691142 alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. |
| GO:0005515 protein binding | IPI PMID:15327768 Mechanism of phosphorylation-dependent binding of APC to bet... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15327768 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. |
| GO:0005515 protein binding | IPI PMID:16293619 Thermodynamics of beta-catenin-ligand interactions: the role... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:16293619 Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. |
| GO:0005515 protein binding | IPI PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. |
| GO:0005515 protein binding | IPI PMID:19107203 Direct inhibition of GSK3beta by the phosphorylated cytoplas... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:19107203 Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. |
| GO:0005515 protein binding | IPI PMID:20531388 Mutant huntingtin-impaired degradation of beta-catenin cause... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:20531388 Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. |
| GO:0005515 protein binding | IPI PMID:20837657 Abelson family kinases regulate Frizzled planar cell polarit... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:20837657 Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. |
| GO:0005515 protein binding | IPI PMID:21103407 The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/Ξ²-catenin... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:21103407 The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/Ξ²-catenin coactivators essential for intestinal homeostasis. |
| GO:0005515 protein binding | IPI PMID:21552260 Nemo kinase phosphorylates Ξ²-catenin to promote ommatidial r... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:21552260 Nemo kinase phosphorylates Ξ²-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-Ξ²-catenin. |
| GO:0005515 protein binding | IPI PMID:21730140 Ezrin-mediated apical integrity is required for intestinal h... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:21730140 Ezrin-mediated apical integrity is required for intestinal homeostasis. |
| GO:0005515 protein binding | IPI PMID:21751375 Functional analysis of novel phosphorylation sites of CREB-b... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:21751375 Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays. |
| GO:0005515 protein binding | IPI PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0005515 protein binding | IPI PMID:23273993 Intestinal tumorigenesis initiated by dedifferentiation and ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:23273993 Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. |
| GO:0005515 protein binding | IPI PMID:25873176 TGIF governs a feed-forward network that empowers Wnt signal... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:25873176 TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis. |
| GO:0005515 protein binding | IPI PMID:26893351 The transcription factor SOX6 contributes to the development... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:26893351 The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. |
| GO:0005515 protein binding | IPI PMID:9264463 A specific domain in alpha-catenin mediates binding to beta-... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:9264463 A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin. |
| GO:0000209 protein polyubiquitination | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: beta-catenin is the polyubiquitinated SUBSTRATE (K48 chains via SCF-BTRC), not the ligase; this IEA/ISO term reflects its targeting for degradation and is non-core. Reason: Substrate (not catalytic) involvement; electronic, kept as non-core. |
| GO:0000791 euchromatin | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: beta-catenin localizes with active TCF/LEF target loci in euchromatin, consistent with its coactivator role, but this CC term is contextual rather than a core function statement. Reason: Localization term supporting, but not equal to, its coactivator function. |
| GO:0001649 osteoblast differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Wnt/beta-catenin is a master driver of osteoblast fate via Runx2/Osterix-linked targets; the differentiation outcome is downstream of that transcription. Reason: Osteoblastogenesis downstream of Wnt/beta-catenin transcriptional program. |
| GO:0003713 transcription coactivator activity | ISO GO_REF:0000119 | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Reported signaling-receptor binding is a generic descriptor of regulatory contacts and not a core, mechanistically defined function. Reason: Semi-generic MF; electronic, peripheral. |
| GO:0005634 nucleus | ISO GO_REF:0000096 | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. |
| GO:0005634 nucleus | ISO GO_REF:0000119 | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. |
| GO:0005667 transcription regulator complex | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. |
| GO:0005737 cytoplasm | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. |
| GO:0005813 centrosome | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal pool acting in centrosome cohesion/separation, distinct from its core adhesion and Wnt roles. Reason: Secondary localization; IDA but non-core moonlighting. |
| GO:0005829 cytosol | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. |
| GO:0005886 plasma membrane | ISO GO_REF:0000096 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005911 cell-cell junction | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. |
| GO:0005912 adherens junction | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005929 cilium | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin is reported at the cilium where Wnt/cytoskeletal regulation occurs; an electronically inferred location (IEA/ISO) secondary to junction and nuclear pools. Reason: electronic secondary localization, non-core |
| GO:0005938 cell cortex | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin associates with the actin-rich cell cortex via the cadherin-catenin complex at cell-cell contacts. Reason: Genuine cortical pool at junctions. |
| GO:0007155 cell adhesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Generic cell adhesion is subsumed by the more specific cadherin-mediated cell-cell adhesion terms that capture beta-catenin's actual mechanism. Reason: Over-general parent; electronic; specific child preferred. |
| GO:0007173 epidermal growth factor receptor signaling pathway | ISO GO_REF:0000119 | REMOVE | Summary: Beta-catenin is a Wnt-pathway effector and adherens-junction protein, not a component of EGFR signaling; this electronically propagated (IEA/ISO) term is biologically misattributed. Reason: electronic; EGFR pathway not a beta-catenin role |
| GO:0008285 negative regulation of cell population proliferation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Electronic/ortholog-inferred anti-proliferative effect in some lineages, downstream of context-specific Wnt transcriptional output. Reason: Context anti-proliferation downstream of transcription; non-core (electronic). |
| GO:0010629 negative regulation of gene expression | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic negative-regulation-of-expression parent; beta-catenin's specific repressive effects act at the level of Pol II transcription of particular targets. Reason: Uninformative broad parent; specific Pol II transcription terms preferred. |
| GO:0010717 regulation of epithelial to mesenchymal transition | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Generic EMT regulation reflects beta-catenin's dual junctional and Wnt-transcriptional control of epithelial plasticity; an electronic/ortholog-inferred downstream process. Reason: Downstream EMT control via Wnt transcription and cadherin-adhesion balance; non-core. |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Nuclear beta-catenin drives EMT transcriptional programs (Snail/Twist targets) while loss of its junctional pool also promotes EMT; the process is downstream of both core roles. Reason: EMT is a transcriptional/adhesion downstream output, not beta-catenin's direct molecular function. |
| GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred up-regulation of HSPG biosynthesis, plausibly via Wnt transcriptional targets; a downstream biosynthetic effect. Reason: HSPG biosynthesis upregulation downstream of transcription; non-core (electronic). |
| GO:0014010 Schwann cell proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Beta-catenin supports Schwann cell proliferation via Wnt/TCF transcriptional output; a peripheral-glia proliferation outcome downstream of its signaling role, not a core molecular function. Reason: ISO-supported downstream Wnt-driven glial proliferation phenotype |
| GO:0014704 intercalated disc | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin is a core structural component of the cardiac intercalated disc, anchoring N-cadherin to the actin cytoskeleton (IDA/ISO); a direct adhesion-structure localization. Reason: direct structural localization at cardiac junction |
| GO:0016020 membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. |
| GO:0016323 basolateral plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. |
| GO:0016324 apical plasma membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Apical plasma membrane pool is a context-specific epithelial localization; beta-catenin junctions are chiefly apicolateral/lateral. Reason: Secondary membrane subdomain; electronic (ISO). |
| GO:0016328 lateral plasma membrane | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin concentrates at the lateral membrane of epithelia where cadherin-based cell-cell junctions assemble. Reason: Genuine core junctional membrane pool; IDA. |
| GO:0016328 lateral plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin concentrates at the lateral membrane of epithelia where cadherin-based cell-cell junctions assemble. Reason: Genuine core junctional membrane pool; IDA. |
| GO:0016342 catenin complex | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). |
| GO:0016922 nuclear receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin coactivates several nuclear receptors (e.g. NR5A2, AR/ER), broadening its transcriptional crosstalk beyond the core TCF/LEF axis. Reason: Crosstalk coactivation; non-core relative to TCF. |
| GO:0019899 enzyme binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Bare 'enzyme binding' is uninformative; beta-catenin's relevant enzyme contacts (GSK3B, CK1, kinases) are captured by specific kinase/phosphatase terms. Reason: Generic MF over-annotation. |
| GO:0019900 kinase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Generic kinase binding reflects contacts with regulatory kinases (GSK3B, CK1, CDKs); informative specificity is in destruction-complex and PTM annotations. Reason: Semi-generic MF; electronic, peripheral. |
| GO:0019902 phosphatase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Phosphatase binding (e.g. PTPRJ/PTPRU) regulates the phosphorylation state of junctional beta-catenin, a regulatory interaction. Reason: Regulatory partner; electronic, non-core. |
| GO:0030054 cell junction | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin is a core cell-junction protein, concentrated at cadherin-based cell-cell junctions. Reason: Core localization (junction parent). |
| GO:0030331 nuclear estrogen receptor binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Estrogen-receptor binding represents nuclear-receptor coactivator crosstalk, secondary to TCF/LEF-based Wnt transcription. Reason: Crosstalk partner; electronic, non-core. |
| GO:0030877 beta-catenin destruction complex | ISO GO_REF:0000119 | ACCEPT | Summary: In the absence of Wnt, beta-catenin is the substrate within the AXIN/APC/GSK3B/CK1 destruction complex that drives its phosphorylation and degradation. Reason: Core Wnt regulation; defining complex membership (IDA/ISS). |
| GO:0030997 regulation of centriole-centriole cohesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal moonlighting role in centriole cohesion; ortholog/electronic-inferred and distinct from its core adhesion/Wnt roles. Reason: Centrosomal moonlighting role, electronic-inferred; non-core. |
| GO:0031396 regulation of protein ubiquitination | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Reflects beta-catenin being targeted for / influencing ubiquitination within the destruction complex; an IEA/ISO regulatory term peripheral to its effector function. Reason: Indirect/substrate-side ubiquitination regulation; electronic, non-core. |
| GO:0031625 ubiquitin protein ligase binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Binding E3 ligases (BTRC/SCF, SIAH1, UBR5) underlies beta-catenin's regulated turnover, a degradation-regulatory interaction. Reason: Regulatory partner; ISO, non-core. |
| GO:0031965 nuclear membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: A nuclear-membrane pool may reflect nucleocytoplasmic shuttling, peripheral to the functional nuclear (chromatin/TCF) and junctional pools. Reason: Secondary localization; ISO. |
| GO:0032355 response to estradiol | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred responsiveness to estradiol, reflecting hormone crosstalk with Wnt/beta-catenin transcription in reproductive tissues; a downstream response. Reason: Estradiol response downstream/crosstalk with Wnt transcription; non-core (electronic). |
| GO:0032991 protein-containing complex | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Bare 'protein-containing complex' is uninformative; beta-catenin's specific complexes (catenin, TCF, destruction) are annotated separately. Reason: Generic CC over-annotation. |
| GO:0032993 protein-DNA complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin is part of protein-DNA complexes only indirectly via TCF/LEF; the specific beta-catenin-TCF complex terms capture this better. Reason: Indirect/over-general; electronic. |
| GO:0033234 negative regulation of protein sumoylation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred negative effect on SUMOylation; an indirect downstream activity unrelated to beta-catenin's core adhesion/Wnt functions. Reason: SUMOylation suppression, electronic-inferred and indirect; non-core. |
| GO:0034097 response to cytokine | ISO GO_REF:0000096 | UNDECIDED | Summary: Sole ISO ortholog-transfer with no specific cytokine context; while crosstalk between beta-catenin and cytokine pathways exists, the bare term is too unspecific to confidently retain or refute. Reason: ISO-only, no specific evidence; mark UNDECIDED rather than REMOVE per electronic-evidence caution. |
| GO:0034112 positive regulation of homotypic cell-cell adhesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Promotion of homotypic adhesion follows from beta-catenin's cadherin role, but the directional regulatory term is electronic and secondary to the structural terms. Reason: Regulatory process; IEA/ISO. |
| GO:0034333 adherens junction assembly | ISO GO_REF:0000119 | ACCEPT | Summary: By linking cadherin to the catenin/actin machinery, beta-catenin is required for adherens junction assembly. Reason: Core adhesion process; mechanistically central even if evidence is electronic/ISS. |
| GO:0034394 protein localization to cell surface | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin promotes surface delivery/retention of cadherin (e.g. via vinculin), a supporting trafficking role secondary to its structural function. Reason: Peripheral process; electronic. |
| GO:0035255 ionotropic glutamate receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Reported binding to ionotropic glutamate receptors is a neuron-specific interaction tied to synaptic adhesion, not a core function. Reason: Specific neuronal partner; ISO. |
| GO:0036064 ciliary basal body | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin has been localized to the ciliary basal body, linking junction/centrosome pools; an electronically inferred location (IEA/ISO) peripheral to its core roles. Reason: electronic minor localization, non-core |
| GO:0043065 positive regulation of apoptotic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: In some contexts beta-catenin promotes apoptosis; this electronic/ortholog-inferred bidirectional effect is a downstream consequence of context-specific transcription. Reason: Context-dependent pro-apoptotic output downstream of transcription; non-core (electronic). |
| GO:0043066 negative regulation of apoptotic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin Wnt targets (e.g. survival genes) can suppress apoptosis; this electronic/ortholog-inferred pro-survival effect is downstream of transcription. Reason: Anti-apoptotic effect downstream of Wnt-target gene expression; non-core (electronic). |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | ISO GO_REF:0000119 | ACCEPT | Summary: Core to beta-catenin level control: phosphorylated beta-catenin is the SUBSTRATE ubiquitinated by SCF(BTRC) and degraded by the proteasome, the switch that gates Wnt signaling. Reason: Defining degradation process that regulates beta-catenin abundance. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research-falcon.md enabling recognition by **Ξ²-TrCP** (E3 ligase adaptor), ubiquitination, and proteasomal degradation |
| GO:0043198 dendritic shaft | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: The dendritic-shaft pool is a neuron-specific localization tied to synaptic adhesion, secondary to core junction/Wnt pools. Reason: Tissue-specific localization; ISO. |
| GO:0043525 positive regulation of neuron apoptotic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog-inferred pro-apoptotic effect on neurons in particular contexts, downstream of beta-catenin's transcriptional program. Reason: Context-specific neuronal apoptosis downstream of Wnt transcription; non-core (electronic). |
| GO:0043627 response to estrogen | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ISO ortholog-inferred estrogen responsiveness, consistent with estrogen-Wnt crosstalk in hormone-responsive tissues; a downstream response phenotype. Reason: Estrogen response via hormone-Wnt crosstalk; non-core (electronic). |
| GO:0044325 transmembrane transporter binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Binding to transmembrane transporters/channels (e.g. TRPV4, SLC30A9) reflects context-specific interactions peripheral to core functions. Reason: Specific peripheral partner class; electronic. |
| GO:0044331 cell-cell adhesion mediated by cadherin | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin mediates cadherin-dependent cell-cell adhesion, the precise process matching its molecular role. Reason: Core, mechanistically specific adhesion term. |
| GO:0044877 protein-containing complex binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: Generic 'complex binding' adds no functional specificity over the named complex-membership and partner-binding terms. Reason: Generic MF over-annotation; ISO. |
| GO:0045294 alpha-catenin binding | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. |
| GO:0045294 alpha-catenin binding | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. |
| GO:0045296 cadherin binding | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045296 cadherin binding | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045892 negative regulation of DNA-templated transcription | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: beta-catenin can repress specific targets (e.g. via SOX9/TCF competition or unliganded-TCF contexts), but its core, defining transcriptional role is positive coactivation of TCF/LEF targets. Reason: Context-dependent repression; secondary to its activating role. |
| GO:0045893 positive regulation of DNA-templated transcription | ISO GO_REF:0000119 | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISO GO_REF:0000119 | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. |
| GO:0046332 SMAD binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: SMAD binding represents BMP/TGF-beta pathway crosstalk, secondary to beta-catenin's cadherin-adhesion and Wnt/TCF core functions. Reason: Crosstalk; electronic (IEA/ISO) and not a core partner class. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: A perinuclear cytoplasmic pool may reflect shuttling/staging intermediates, secondary to functional junctional and nuclear pools. Reason: Secondary localization; electronic. |
| GO:0048471 perinuclear region of cytoplasm | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: A perinuclear cytoplasmic pool may reflect shuttling/staging intermediates, secondary to functional junctional and nuclear pools. Reason: Secondary localization; electronic. |
| GO:0048660 regulation of smooth muscle cell proliferation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Modulation of vascular/visceral smooth muscle proliferation reflects Wnt/beta-catenin mitogenic target genes; ortholog/electronic-inferred downstream process. Reason: Downstream proliferative control via Wnt transcriptional targets; non-core. |
| GO:0050998 nitric-oxide synthase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: eNOS-associated binding relates to S-nitrosylation-regulated junction disassembly in endothelium, a regulatory crosstalk interaction. Reason: Specific partner; ISO, peripheral. |
| GO:0060070 canonical Wnt signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060231 mesenchymal to epithelial transition | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin contributes to MET through cadherin-junction assembly and Wnt transcriptional balance; a cell-state transition (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt MET role |
| GO:0061154 endothelial tube morphogenesis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin supports endothelial tube formation via junctional integrity and Wnt transcription; a vascular morphogenetic outcome (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt vascular roles |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin directly binds Pol II-specific DNA-binding transcription factors (TCF/LEF) to drive Wnt-responsive transcription. Reason: Core Wnt coactivation; IDA-supported specific TF binding. |
| GO:0070097 delta-catenin binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Binding to delta-catenin (CTNND2) occurs in neuronal contexts; p120/delta-catenin family members bind the cadherin juxtamembrane region, a secondary interaction for beta-catenin. Reason: Specific partner binding; ISO and peripheral. |
| GO:0070160 tight junction | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin localizes to the tight-junction-associated region of the epithelial apical junctional complex via cadherin-catenin contacts. Reason: Junctional localization within apical complex; retain (ISO). |
| GO:0070369 beta-catenin-TCF7L2 complex | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin forms the specific transcriptional complex with TCF7L2/TCF4 that activates Wnt target genes. Reason: Core Wnt effector complex (specific TCF member). |
| GO:0070411 I-SMAD binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Inhibitory-SMAD binding reflects TGF-beta/BMP crosstalk rather than the canonical cadherin or Wnt/TCF functions of beta-catenin. Reason: Crosstalk binding; electronic (IEA/ISO) and peripheral to core roles. |
| GO:0070602 regulation of centromeric sister chromatid cohesion | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: A reported beta-catenin role at centromeric cohesion is a moonlighting function separate from its Wnt/adhesion core; supported by IMP plus electronic inference. Reason: Sister-chromatid cohesion moonlighting role; non-core to Wnt/adhesion. |
| GO:0071260 cellular response to mechanical stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Mechanical force at adherens junctions modulates beta-catenin release/signaling (mechanotransduction); a context response (ISO) downstream of its junctional role. Reason: ISO mechanotransduction downstream of junction role |
| GO:0071363 cellular response to growth factor stimulus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin participates in growth-factor-responsive transcription via Wnt crosstalk; a broad, electronically inferred response, kept as non-core given indirect linkage. Reason: electronic/generic; indirect crosstalk, not core |
| GO:0071681 cellular response to indole-3-methanol | ISO GO_REF:0000119 | REMOVE | Summary: No credible biological basis for beta-catenin as a responder to indole-3-methanol; an electronically propagated (IEA/ISO/ISS) annotation with no support. Reason: electronic annotation biologically unsupported for this gene |
| GO:0071944 cell periphery | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin localizes to the cell periphery at adherens junctions linking cadherins to actin; a broad location term consistent with its structural role but less specific than the junction terms. Reason: electronic broad location subsumed by adherens-junction terms |
| GO:0072497 mesenchymal stem cell differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin directs MSC lineage choice (osteo/chondro/adipo) via Wnt/TCF transcription; a stem-cell fate outcome downstream of signaling. Reason: downstream Wnt-driven MSC differentiation |
| GO:0090279 regulation of calcium ion import | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred influence on calcium import, distinct from beta-catenin's core Wnt/adhesion roles; a downstream/indirect effect. Reason: Calcium-import regulation, electronic-inferred and indirect; non-core. |
| GO:0098609 cell-cell adhesion | ISO GO_REF:0000096 | ACCEPT | Summary: Beta-catenin is essential for cadherin-based cell-cell adhesion, anchoring the adhesion complex to the cytoskeleton. Reason: Core adhesion process; IBA/IMP-supported. |
| GO:0140297 DNA-binding transcription factor binding | ISO GO_REF:0000119 | ACCEPT | Summary: Beta-catenin binds TCF/LEF DNA-binding transcription factors to coactivate Wnt target genes; core to its nuclear Wnt-effector role. Reason: Core Wnt: direct TCF/LEF coactivation (IPI); foundational MF for the transcriptional arm. |
| GO:1905555 positive regulation of blood vessel branching | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling promotes endothelial branching morphogenesis via target-gene expression; ortholog-inferred downstream vascular process. Reason: Vessel branching is downstream of Wnt/beta-catenin endothelial transcription. |
| GO:1990138 neuron projection extension | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred role in axon/dendrite outgrowth, plausibly via cadherin-junction and Wnt-transcriptional inputs; a downstream neuronal phenotype. Reason: Neurite extension downstream of adhesion/Wnt roles; non-core (electronic). |
| GO:1990314 cellular response to insulin-like growth factor stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Beta-catenin can be engaged in IGF-responsive transcriptional output via signaling crosstalk; an indirect response (ISO) kept as non-core, not a core IGF-pathway role. Reason: ISO indirect IGF crosstalk, not core function |
| GO:1990907 beta-catenin-TCF complex | ISO GO_REF:0000119 | ACCEPT | Summary: The nuclear beta-catenin-TCF complex is the central transcriptional effector unit of canonical Wnt signaling. Reason: Core Wnt effector complex; IDA-supported. |
| GO:2000008 regulation of protein localization to cell surface | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Beta-catenin modulates cadherin surface levels, a regulatory trafficking role secondary to its structural junction function. Reason: Peripheral regulatory process; electronic. |
| GO:0000209 protein polyubiquitination | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: beta-catenin is the polyubiquitinated SUBSTRATE (K48 chains via SCF-BTRC), not the ligase; this IEA/ISO term reflects its targeting for degradation and is non-core. Reason: Substrate (not catalytic) involvement; electronic, kept as non-core. |
| GO:0000791 euchromatin | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: beta-catenin localizes with active TCF/LEF target loci in euchromatin, consistent with its coactivator role, but this CC term is contextual rather than a core function statement. Reason: Localization term supporting, but not equal to, its coactivator function. |
| GO:0001649 osteoblast differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Wnt/beta-catenin is a master driver of osteoblast fate via Runx2/Osterix-linked targets; the differentiation outcome is downstream of that transcription. Reason: Osteoblastogenesis downstream of Wnt/beta-catenin transcriptional program. |
| GO:0003713 transcription coactivator activity | IEA GO_REF:0000107 | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005102 signaling receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported signaling-receptor binding is a generic descriptor of regulatory contacts and not a core, mechanistically defined function. Reason: Semi-generic MF; electronic, peripheral. |
| GO:0005667 transcription regulator complex | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. |
| GO:0005929 cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin is reported at the cilium where Wnt/cytoskeletal regulation occurs; an electronically inferred location (IEA/ISO) secondary to junction and nuclear pools. Reason: electronic secondary localization, non-core |
| GO:0005938 cell cortex | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin associates with the actin-rich cell cortex via the cadherin-catenin complex at cell-cell contacts. Reason: Genuine cortical pool at junctions. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IEA GO_REF:0000107 | REMOVE | Summary: Beta-catenin is a Wnt-pathway effector and adherens-junction protein, not a component of EGFR signaling; this electronically propagated (IEA/ISO) term is biologically misattributed. Reason: electronic; EGFR pathway not a beta-catenin role |
| GO:0008285 negative regulation of cell population proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Electronic/ortholog-inferred anti-proliferative effect in some lineages, downstream of context-specific Wnt transcriptional output. Reason: Context anti-proliferation downstream of transcription; non-core (electronic). |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA-inferred xenobiotic responsiveness; an indirect downstream response not central to beta-catenin's adhesion or Wnt-transcriptional function. Reason: Xenobiotic response, IEA-inferred and indirect; non-core. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research-falcon.md enabling recognition by **Ξ²-TrCP** (E3 ligase adaptor), ubiquitination, and proteasomal degradation |
| GO:0010717 regulation of epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Generic EMT regulation reflects beta-catenin's dual junctional and Wnt-transcriptional control of epithelial plasticity; an electronic/ortholog-inferred downstream process. Reason: Downstream EMT control via Wnt transcription and cadherin-adhesion balance; non-core. |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Nuclear beta-catenin drives EMT transcriptional programs (Snail/Twist targets) while loss of its junctional pool also promotes EMT; the process is downstream of both core roles. Reason: EMT is a transcriptional/adhesion downstream output, not beta-catenin's direct molecular function. |
| GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred up-regulation of HSPG biosynthesis, plausibly via Wnt transcriptional targets; a downstream biosynthetic effect. Reason: HSPG biosynthesis upregulation downstream of transcription; non-core (electronic). |
| GO:0016323 basolateral plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. |
| GO:0016328 lateral plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin concentrates at the lateral membrane of epithelia where cadherin-based cell-cell junctions assemble. Reason: Genuine core junctional membrane pool; IDA. |
| GO:0016342 catenin complex | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). |
| GO:0016922 nuclear receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin coactivates several nuclear receptors (e.g. NR5A2, AR/ER), broadening its transcriptional crosstalk beyond the core TCF/LEF axis. Reason: Crosstalk coactivation; non-core relative to TCF. |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Bare 'enzyme binding' is uninformative; beta-catenin's relevant enzyme contacts (GSK3B, CK1, kinases) are captured by specific kinase/phosphatase terms. Reason: Generic MF over-annotation. |
| GO:0019900 kinase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Generic kinase binding reflects contacts with regulatory kinases (GSK3B, CK1, CDKs); informative specificity is in destruction-complex and PTM annotations. Reason: Semi-generic MF; electronic, peripheral. |
| GO:0019902 phosphatase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Phosphatase binding (e.g. PTPRJ/PTPRU) regulates the phosphorylation state of junctional beta-catenin, a regulatory interaction. Reason: Regulatory partner; electronic, non-core. |
| GO:0030054 cell junction | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin is a core cell-junction protein, concentrated at cadherin-based cell-cell junctions. Reason: Core localization (junction parent). |
| GO:0030331 nuclear estrogen receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Estrogen-receptor binding represents nuclear-receptor coactivator crosstalk, secondary to TCF/LEF-based Wnt transcription. Reason: Crosstalk partner; electronic, non-core. |
| GO:0030877 beta-catenin destruction complex | IEA GO_REF:0000107 | ACCEPT | Summary: In the absence of Wnt, beta-catenin is the substrate within the AXIN/APC/GSK3B/CK1 destruction complex that drives its phosphorylation and degradation. Reason: Core Wnt regulation; defining complex membership (IDA/ISS). |
| GO:0030997 regulation of centriole-centriole cohesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal moonlighting role in centriole cohesion; ortholog/electronic-inferred and distinct from its core adhesion/Wnt roles. Reason: Centrosomal moonlighting role, electronic-inferred; non-core. |
| GO:0031396 regulation of protein ubiquitination | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reflects beta-catenin being targeted for / influencing ubiquitination within the destruction complex; an IEA/ISO regulatory term peripheral to its effector function. Reason: Indirect/substrate-side ubiquitination regulation; electronic, non-core. |
| GO:0032355 response to estradiol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred responsiveness to estradiol, reflecting hormone crosstalk with Wnt/beta-catenin transcription in reproductive tissues; a downstream response. Reason: Estradiol response downstream/crosstalk with Wnt transcription; non-core (electronic). |
| GO:0032991 protein-containing complex | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Bare 'protein-containing complex' is uninformative; beta-catenin's specific complexes (catenin, TCF, destruction) are annotated separately. Reason: Generic CC over-annotation. |
| GO:0032993 protein-DNA complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin is part of protein-DNA complexes only indirectly via TCF/LEF; the specific beta-catenin-TCF complex terms capture this better. Reason: Indirect/over-general; electronic. |
| GO:0033234 negative regulation of protein sumoylation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred negative effect on SUMOylation; an indirect downstream activity unrelated to beta-catenin's core adhesion/Wnt functions. Reason: SUMOylation suppression, electronic-inferred and indirect; non-core. |
| GO:0034112 positive regulation of homotypic cell-cell adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Promotion of homotypic adhesion follows from beta-catenin's cadherin role, but the directional regulatory term is electronic and secondary to the structural terms. Reason: Regulatory process; IEA/ISO. |
| GO:0034333 adherens junction assembly | IEA GO_REF:0000107 | ACCEPT | Summary: By linking cadherin to the catenin/actin machinery, beta-catenin is required for adherens junction assembly. Reason: Core adhesion process; mechanistically central even if evidence is electronic/ISS. |
| GO:0034394 protein localization to cell surface | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin promotes surface delivery/retention of cadherin (e.g. via vinculin), a supporting trafficking role secondary to its structural function. Reason: Peripheral process; electronic. |
| GO:0036064 ciliary basal body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin has been localized to the ciliary basal body, linking junction/centrosome pools; an electronically inferred location (IEA/ISO) peripheral to its core roles. Reason: electronic minor localization, non-core |
| GO:0043065 positive regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: In some contexts beta-catenin promotes apoptosis; this electronic/ortholog-inferred bidirectional effect is a downstream consequence of context-specific transcription. Reason: Context-dependent pro-apoptotic output downstream of transcription; non-core (electronic). |
| GO:0043066 negative regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin Wnt targets (e.g. survival genes) can suppress apoptosis; this electronic/ortholog-inferred pro-survival effect is downstream of transcription. Reason: Anti-apoptotic effect downstream of Wnt-target gene expression; non-core (electronic). |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | IEA GO_REF:0000107 | ACCEPT | Summary: Core to beta-catenin level control: phosphorylated beta-catenin is the SUBSTRATE ubiquitinated by SCF(BTRC) and degraded by the proteasome, the switch that gates Wnt signaling. Reason: Defining degradation process that regulates beta-catenin abundance. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research-falcon.md enabling recognition by **Ξ²-TrCP** (E3 ligase adaptor), ubiquitination, and proteasomal degradation |
| GO:0043525 positive regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-inferred pro-apoptotic effect on neurons in particular contexts, downstream of beta-catenin's transcriptional program. Reason: Context-specific neuronal apoptosis downstream of Wnt transcription; non-core (electronic). |
| GO:0044325 transmembrane transporter binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Binding to transmembrane transporters/channels (e.g. TRPV4, SLC30A9) reflects context-specific interactions peripheral to core functions. Reason: Specific peripheral partner class; electronic. |
| GO:0044331 cell-cell adhesion mediated by cadherin | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin mediates cadherin-dependent cell-cell adhesion, the precise process matching its molecular role. Reason: Core, mechanistically specific adhesion term. |
| GO:0045294 alpha-catenin binding | IEA GO_REF:0000120 | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. |
| GO:0045892 negative regulation of DNA-templated transcription | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: beta-catenin can repress specific targets (e.g. via SOX9/TCF competition or unliganded-TCF contexts), but its core, defining transcriptional role is positive coactivation of TCF/LEF targets. Reason: Context-dependent repression; secondary to its activating role. |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000107 | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IEA GO_REF:0000107 | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. |
| GO:0046332 SMAD binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: SMAD binding represents BMP/TGF-beta pathway crosstalk, secondary to beta-catenin's cadherin-adhesion and Wnt/TCF core functions. Reason: Crosstalk; electronic (IEA/ISO) and not a core partner class. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: A perinuclear cytoplasmic pool may reflect shuttling/staging intermediates, secondary to functional junctional and nuclear pools. Reason: Secondary localization; electronic. |
| GO:0048660 regulation of smooth muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Modulation of vascular/visceral smooth muscle proliferation reflects Wnt/beta-catenin mitogenic target genes; ortholog/electronic-inferred downstream process. Reason: Downstream proliferative control via Wnt transcriptional targets; non-core. |
| GO:0060070 canonical Wnt signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060231 mesenchymal to epithelial transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin contributes to MET through cadherin-junction assembly and Wnt transcriptional balance; a cell-state transition (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt MET role |
| GO:0061154 endothelial tube morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin supports endothelial tube formation via junctional integrity and Wnt transcription; a vascular morphogenetic outcome (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt vascular roles |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin directly binds Pol II-specific DNA-binding transcription factors (TCF/LEF) to drive Wnt-responsive transcription. Reason: Core Wnt coactivation; IDA-supported specific TF binding. |
| GO:0070369 beta-catenin-TCF7L2 complex | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin forms the specific transcriptional complex with TCF7L2/TCF4 that activates Wnt target genes. Reason: Core Wnt effector complex (specific TCF member). |
| GO:0070411 I-SMAD binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Inhibitory-SMAD binding reflects TGF-beta/BMP crosstalk rather than the canonical cadherin or Wnt/TCF functions of beta-catenin. Reason: Crosstalk binding; electronic (IEA/ISO) and peripheral to core roles. |
| GO:0070602 regulation of centromeric sister chromatid cohesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: A reported beta-catenin role at centromeric cohesion is a moonlighting function separate from its Wnt/adhesion core; supported by IMP plus electronic inference. Reason: Sister-chromatid cohesion moonlighting role; non-core to Wnt/adhesion. |
| GO:0071363 cellular response to growth factor stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin participates in growth-factor-responsive transcription via Wnt crosstalk; a broad, electronically inferred response, kept as non-core given indirect linkage. Reason: electronic/generic; indirect crosstalk, not core |
| GO:0071681 cellular response to indole-3-methanol | IEA GO_REF:0000107 | REMOVE | Summary: No credible biological basis for beta-catenin as a responder to indole-3-methanol; an electronically propagated (IEA/ISO/ISS) annotation with no support. Reason: electronic annotation biologically unsupported for this gene |
| GO:0071944 cell periphery | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin localizes to the cell periphery at adherens junctions linking cadherins to actin; a broad location term consistent with its structural role but less specific than the junction terms. Reason: electronic broad location subsumed by adherens-junction terms |
| GO:0072497 mesenchymal stem cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin directs MSC lineage choice (osteo/chondro/adipo) via Wnt/TCF transcription; a stem-cell fate outcome downstream of signaling. Reason: downstream Wnt-driven MSC differentiation |
| GO:0090279 regulation of calcium ion import | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred influence on calcium import, distinct from beta-catenin's core Wnt/adhesion roles; a downstream/indirect effect. Reason: Calcium-import regulation, electronic-inferred and indirect; non-core. |
| GO:0140297 DNA-binding transcription factor binding | IEA GO_REF:0000107 | ACCEPT | Summary: Beta-catenin binds TCF/LEF DNA-binding transcription factors to coactivate Wnt target genes; core to its nuclear Wnt-effector role. Reason: Core Wnt: direct TCF/LEF coactivation (IPI); foundational MF for the transcriptional arm. |
| GO:1905555 positive regulation of blood vessel branching | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling promotes endothelial branching morphogenesis via target-gene expression; ortholog-inferred downstream vascular process. Reason: Vessel branching is downstream of Wnt/beta-catenin endothelial transcription. |
| GO:1990138 neuron projection extension | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred role in axon/dendrite outgrowth, plausibly via cadherin-junction and Wnt-transcriptional inputs; a downstream neuronal phenotype. Reason: Neurite extension downstream of adhesion/Wnt roles; non-core (electronic). |
| GO:1990907 beta-catenin-TCF complex | IEA GO_REF:0000107 | ACCEPT | Summary: The nuclear beta-catenin-TCF complex is the central transcriptional effector unit of canonical Wnt signaling. Reason: Core Wnt effector complex; IDA-supported. |
| GO:2000008 regulation of protein localization to cell surface | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Beta-catenin modulates cadherin surface levels, a regulatory trafficking role secondary to its structural junction function. Reason: Peripheral regulatory process; electronic. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcr... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IDA PMID:10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-in... | KEEP AS NON CORE | Summary: An IDA call; beta-catenin represses certain Pol II targets in specific contexts, but this should be downgraded relative to its core activating coactivator role, not removed. Reason: Experimental (IDA); downgrade context-specific repression, do not REMOVE. Supporting Evidence: PMID:10898789 ICAT repressed the activity of the reporter gene in both cell lines in a dose-dependent manner |
| GO:0005634 nucleus | IDA PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 exp... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. |
| GO:0045597 positive regulation of cell differentiation | NAS PMID:24847765 From inception to output, Tcf1 and Lef1 safeguard developmen... | KEEP AS NON CORE | Summary: NAS-supported broad pro-differentiation role reflecting beta-catenin Wnt-driven fate gene activation; a downstream, non-specific process. Reason: Umbrella pro-differentiation downstream of Wnt transcription (NAS). Supporting Evidence: PMID:24847765 From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 exp... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. |
| GO:0050767 regulation of neurogenesis | NAS PMID:23377854 Physiological role of Ξ²-catenin/TCF signaling in neurons of ... | KEEP AS NON CORE | Summary: NAS-supported broad neurogenesis regulation reflecting beta-catenin's Wnt control of neural progenitor fate/proliferation; a downstream umbrella process. Reason: Umbrella neurogenesis regulation downstream of Wnt transcription (NAS). Supporting Evidence: PMID:23377854 Physiological role of Ξ²-catenin/TCF signaling in neurons of the adult brain. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 exp... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:16936075 The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IDA PMID:10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-in... | KEEP AS NON CORE | Summary: IDA-supported feedback/auto-regulatory role (e.g. via SOX9-mediated degradation, Axin2 induction); real but a regulatory facet rather than the core effector function. Reason: Feedback regulation of its own pathway; non-core regulatory facet. Supporting Evidence: PMID:10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. |
| GO:0090575 RNA polymerase II transcription regulator complex | IPI PMID:21075118 Biochemical and structural characterization of Ξ²-catenin int... | ACCEPT | Summary: As a TCF/LEF coactivator beta-catenin is a component of Pol II transcription regulator complexes on Wnt target promoters. Reason: Core nuclear Wnt effector; IPI-supported complex membership. Supporting Evidence: PMID:21075118 Biochemical and structural characterization of Ξ²-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. |
| GO:1990711 beta-catenin-ICAT complex | IPI PMID:10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-in... | KEEP AS NON CORE | Summary: ICAT (CTNNBIP1) binding sequesters beta-catenin from TCF/p300, an inhibitory complex regulating signaling rather than a core effector assembly. Reason: Inhibitory regulatory complex; IPI but peripheral. Supporting Evidence: PMID:10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. |
| GO:0005912 adherens junction | IDA PMID:12494996 Loss of desmoglein 2 suggests essential functions for early ... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:12494996 Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0010717 regulation of epithelial to mesenchymal transition | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Generic EMT regulation reflects beta-catenin's dual junctional and Wnt-transcriptional control of epithelial plasticity; an electronic/ortholog-inferred downstream process. Reason: Downstream EMT control via Wnt transcription and cadherin-adhesion balance; non-core. |
| GO:0060231 mesenchymal to epithelial transition | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin contributes to MET through cadherin-junction assembly and Wnt transcriptional balance; a cell-state transition (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt MET role |
| GO:0003713 transcription coactivator activity | IDA PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:1990226 histone methyltransferase binding | IPI PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: Beta-catenin can recruit chromatin-modifying machinery (e.g. SET/MLL methyltransferases) to Wnt targets, a coactivator-associated but specialized interaction. Reason: Specific partner binding; IPI, peripheral. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0005737 cytoplasm | IDA PMID:27375112 Antagonistic Regulation of Intercellular Cohesion by Plakoph... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:27375112 Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. |
| GO:0005912 adherens junction | IDA PMID:27375112 Antagonistic Regulation of Intercellular Cohesion by Plakoph... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:27375112 Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005634 nucleus | IDA PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical ... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. |
| GO:0005737 cytoplasm | IDA PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical ... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. |
| GO:0005886 plasma membrane | IDA PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical ... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:27015268 Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. |
| GO:0042734 presynaptic membrane | IDA PMID:8909549 The catenin/cadherin adhesion system is localized in synapti... | KEEP AS NON CORE | Summary: A presynaptic-membrane pool reflects synaptic cadherin adhesion, secondary to core junctional localization. Reason: Synapse-specific; IDA, non-core. Supporting Evidence: PMID:8909549 The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. |
| GO:0045211 postsynaptic membrane | IDA PMID:8909549 The catenin/cadherin adhesion system is localized in synapti... | KEEP AS NON CORE | Summary: A postsynaptic-membrane pool supports synaptic cadherin adhesion in neurons, a tissue-specific localization. Reason: Synapse-specific; IDA, non-core. Supporting Evidence: PMID:8909549 The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. |
| GO:0051963 regulation of synapse assembly | IMP PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Comp... | KEEP AS NON CORE | Summary: Beta-catenin regulates synapse assembly via cadherin adhesion in neurons, a tissue-specific role distinct from core epithelial functions. Reason: Neuronal process; IDA/IMP, non-core. Supporting Evidence: PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. |
| GO:0051963 regulation of synapse assembly | IDA PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Comp... | KEEP AS NON CORE | Summary: Beta-catenin regulates synapse assembly via cadherin adhesion in neurons, a tissue-specific role distinct from core epithelial functions. Reason: Neuronal process; IDA/IMP, non-core. Supporting Evidence: PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. |
| GO:0097091 synaptic vesicle clustering | IMP PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin organizes presynaptic vesicle clustering through cadherin-junction scaffolding at synapses; a downstream adhesion-linked synaptic role. Reason: Vesicle clustering downstream of cadherin-adhesion scaffolding role. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0097091 synaptic vesicle clustering | IDA PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin organizes presynaptic vesicle clustering through cadherin-junction scaffolding at synapses; a downstream adhesion-linked synaptic role. Reason: Vesicle clustering downstream of cadherin-adhesion scaffolding role. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0098685 Schaffer collateral - CA1 synapse | IMP PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin localizes to specific hippocampal CA1 synapses where it organizes synaptic adhesion, a tissue-restricted role distinct from its core junction/Wnt functions. Reason: Synapse-specific neuronal localization; real (IDA/IMP) but peripheral. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0098685 Schaffer collateral - CA1 synapse | IDA PMID:14622577 Role of beta-catenin in synaptic vesicle localization and pr... | KEEP AS NON CORE | Summary: Beta-catenin localizes to specific hippocampal CA1 synapses where it organizes synaptic adhesion, a tissue-restricted role distinct from its core junction/Wnt functions. Reason: Synapse-specific neuronal localization; real (IDA/IMP) but peripheral. Supporting Evidence: PMID:14622577 Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. |
| GO:0098831 presynaptic active zone cytoplasmic component | IDA PMID:8909549 The catenin/cadherin adhesion system is localized in synapti... | KEEP AS NON CORE | Summary: Beta-catenin (with Scrib) localizes to the presynaptic active zone organizing vesicle clustering, a specialized neuronal role. Reason: Synapse-specific localization; IDA, non-core. Supporting Evidence: PMID:8909549 The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. |
| GO:0098978 glutamatergic synapse | IMP PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Comp... | KEEP AS NON CORE | Summary: Beta-catenin localizes to glutamatergic synapses where cadherin adhesion organizes synaptic structure, a neuron-specific role. Reason: Synapse-specific localization; IDA/IMP, non-core. Supporting Evidence: PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. |
| GO:0098978 glutamatergic synapse | IDA PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Comp... | KEEP AS NON CORE | Summary: Beta-catenin localizes to glutamatergic synapses where cadherin adhesion organizes synaptic structure, a neuron-specific role. Reason: Synapse-specific localization; IDA/IMP, non-core. Supporting Evidence: PMID:28641114 A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. |
| GO:0099092 postsynaptic density, intracellular component | IDA PMID:8909549 The catenin/cadherin adhesion system is localized in synapti... | KEEP AS NON CORE | Summary: Beta-catenin localizes to the postsynaptic density via cadherin-based synaptic adhesion; a localization reflecting its adhesion/scaffolding role rather than Wnt signaling. Reason: PSD localization via cadherin adhesion role; non-core component annotation. Supporting Evidence: PMID:8909549 The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. |
| GO:0048568 embryonic organ development | IMP PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in p... | MARK AS OVER ANNOTATED | Summary: Broad embryonic-organ umbrella conveying nothing beta-catenin-specific; the many specific organ terms already capture its Wnt-driven developmental roles. Reason: vague umbrella superseded by specific organ terms Supporting Evidence: PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. |
| GO:0072497 mesenchymal stem cell differentiation | IMP PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in p... | KEEP AS NON CORE | Summary: Beta-catenin directs MSC lineage choice (osteo/chondro/adipo) via Wnt/TCF transcription; a stem-cell fate outcome downstream of signaling. Reason: downstream Wnt-driven MSC differentiation Supporting Evidence: PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. |
| GO:0003713 transcription coactivator activity | IDA PMID:15905404 Functional interaction between beta-catenin and FOXO in oxid... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:15905404 Functional interaction between beta-catenin and FOXO in oxidative stress signaling. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0036520 astrocyte-dopaminergic neuron signaling | IMP PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a... | KEEP AS NON CORE | Summary: Beta-catenin contributes to astrocyte-dopaminergic neuron crosstalk supporting midbrain DA neurogenesis; a niche-signaling outcome downstream of Wnt transcription. Reason: downstream Wnt role in DA neuron niche signaling Supporting Evidence: PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neuro... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003151 outflow tract morphogenesis | IMP PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling in second-heart-field/neural-crest shapes the cardiac outflow tract; a downstream cardiac-morphogenesis phenotype. Reason: Outflow tract morphogenesis downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | KEEP AS NON CORE | Summary: Beta-catenin drives proliferation via Wnt mitogenic targets (Myc, cyclin D1); a key but downstream consequence of its transcriptional coactivation. Reason: Proliferation downstream of Wnt target genes Myc/CcnD1; non-core. Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. |
| GO:1901331 positive regulation of odontoblast differentiation | IMP PMID:29148101 Homeobox protein MSX-1 inhibits expression of bone morphogen... | KEEP AS NON CORE | Summary: Beta-catenin promotes odontoblast differentiation via Wnt-target transcription in dental mesenchyme; a downstream lineage phenotype. Reason: Odontoblast differentiation downstream of Wnt transcription. Supporting Evidence: PMID:29148101 Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/Ξ²-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. |
| GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | IMP PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a... | KEEP AS NON CORE | Summary: Beta-catenin attenuates oxidative-stress-triggered neuronal intrinsic apoptosis, likely through Wnt survival-gene output; a specific stress-protection phenotype. Reason: Stress-specific neuroprotection downstream of Wnt transcription; non-core. Supporting Evidence: PMID:21752258 A Wnt1 regulated Frizzled-1/Ξ²-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. |
| GO:0005515 protein binding | IPI PMID:32533114 ADNP promotes neural differentiation by modulating Wnt/Ξ²-cat... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:32533114 ADNP promotes neural differentiation by modulating Wnt/Ξ²-catenin signaling. |
| GO:0003682 chromatin binding | IDA PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. |
| GO:0003682 chromatin binding | IDA PMID:16818445 Wnt9a signaling is required for joint integrity and regulati... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:16818445 Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. |
| GO:0003682 chromatin binding | IDA PMID:17767158 Modulation of morphogenesis by noncanonical Wnt signaling re... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:17767158 Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. |
| GO:0003682 chromatin binding | IDA PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. |
| GO:0003682 chromatin binding | IDA PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. |
| GO:0003682 chromatin binding | IDA PMID:19690384 Wnt signaling regulates smooth muscle precursor development ... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:19690384 Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. |
| GO:0003682 chromatin binding | IDA PMID:20159597 Characterization and in vivo pharmacological rescue of a Wnt... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:20159597 Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. |
| GO:0003682 chromatin binding | IDA PMID:21350016 Canonical Wnt9b signaling balances progenitor cell expansion... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:21350016 Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. |
| GO:0003682 chromatin binding | IDA PMID:21512031 Hippo pathway inhibits Wnt signaling to restrain cardiomyocy... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:21512031 Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. |
| GO:0003682 chromatin binding | IGI PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is e... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. |
| GO:0003713 transcription coactivator activity | IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003713 transcription coactivator activity | IDA PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003713 transcription coactivator activity | IDA PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003713 transcription coactivator activity | IDA PMID:19056892 A functional link between Wnt signaling and SKP2-independent... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:19056892 A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003713 transcription coactivator activity | IMP PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:19619491 Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005515 protein binding | IPI PMID:10318824 Functional domains of axin. Importance of the C terminus as ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:10318824 Functional domains of axin. Importance of the C terminus as an oligomerization domain. |
| GO:0005515 protein binding | IPI PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphoryla... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. |
| GO:0005515 protein binding | IPI PMID:12432063 Protein kinase CKII regulates the interaction of beta-cateni... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12432063 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. |
| GO:0005515 protein binding | IPI PMID:12695331 NF2 deficiency promotes tumorigenesis and metastasis by dest... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12695331 NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. |
| GO:0005515 protein binding | IPI PMID:12861022 T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, s... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:12861022 T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. |
| GO:0005515 protein binding | IPI PMID:14647292 Mammalian formin-1 participates in adherens junctions and po... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:14647292 Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. |
| GO:0005515 protein binding | IPI PMID:14960280 Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-c... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:14960280 Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. |
| GO:0005515 protein binding | IPI PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. |
| GO:0005515 protein binding | IPI PMID:15781477 Sox2 induction by FGF and FGFR2 activating mutations inhibit... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15781477 Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. |
| GO:0005515 protein binding | IPI PMID:15834408 The KIF3 motor transports N-cadherin and organizes the devel... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15834408 The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. |
| GO:0005515 protein binding | IPI PMID:16368433 Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is asso... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:16368433 Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. |
| GO:0005515 protein binding | IPI PMID:17535849 A unique and specific interaction between alphaT-catenin and... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:17535849 A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. |
| GO:0005515 protein binding | IPI PMID:18202148 Cooperative control via lymphoid enhancer factor 1/T cell fa... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:18202148 Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. |
| GO:0005515 protein binding | IPI PMID:18632848 SUMOylation target sites at the C terminus protect Axin from... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:18632848 SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. |
| GO:0005515 protein binding | IPI PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:19503085 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. |
| GO:0005515 protein binding | IPI PMID:19725955 Arginine methyltransferase CARM1/PRMT4 regulates endochondra... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:19725955 Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. |
| GO:0005515 protein binding | IPI PMID:21512031 Hippo pathway inhibits Wnt signaling to restrain cardiomyocy... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:21512031 Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. |
| GO:0005515 protein binding | IPI PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt sig... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. |
| GO:0005515 protein binding | IPI PMID:26787558 SPECC1L deficiency results in increased adherens junction st... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:26787558 SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. |
| GO:0005515 protein binding | IPI PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage deg... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
| GO:0005515 protein binding | IPI PMID:8555428 Immunotoxicologic effects of ethylene dibromide in the mouse... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:8555428 Immunotoxicologic effects of ethylene dibromide in the mouse and their modulation by the estrous cycle. |
| GO:0005515 protein binding | IPI PMID:9488439 Two members of the Tcf family implicated in Wnt/beta-catenin... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:9488439 Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |
| GO:0005515 protein binding | IPI PMID:9554852 Functional interaction of an axin homolog, conductin, with b... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:9554852 Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. |
| GO:0005634 nucleus | IPI PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage deg... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
| GO:0005634 nucleus | IDA PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin ... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. |
| GO:0005634 nucleus | IDA PMID:11731265 Expression of Tcf/Lef and sFrp and localization of beta-cate... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:11731265 Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung. |
| GO:0005634 nucleus | IDA PMID:11872843 Colorectal cancer in mice genetically deficient in the mucin... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:11872843 Colorectal cancer in mice genetically deficient in the mucin Muc2. |
| GO:0005634 nucleus | IDA PMID:12874278 The PDZ protein tax-interacting protein-1 inhibits beta-cate... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:12874278 The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. |
| GO:0005634 nucleus | IDA PMID:12885771 beta-Catenin is required for specification of proximal/dista... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:12885771 beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. |
| GO:0005634 nucleus | IDA PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP recepto... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. |
| GO:0005634 nucleus | IDA PMID:15371327 Wnt/beta-catenin signaling is sufficient and necessary for s... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15371327 Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. |
| GO:0005634 nucleus | IDA PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. |
| GO:0005634 nucleus | IDA PMID:15778706 Wnt signalling induces maturation of Paneth cells in intesti... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15778706 Wnt signalling induces maturation of Paneth cells in intestinal crypts. |
| GO:0005634 nucleus | IDA PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts fr... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15866163 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. |
| GO:0005634 nucleus | IDA PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts contro... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15866165 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. |
| GO:0005634 nucleus | IDA PMID:16439479 Foxf1 and Foxf2 control murine gut development by limiting m... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16439479 Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. |
| GO:0005634 nucleus | IDA PMID:16489008 Patched1 functions as a gatekeeper by promoting cell cycle p... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16489008 Patched1 functions as a gatekeeper by promoting cell cycle progression. |
| GO:0005634 nucleus | IDA PMID:16678815 Lef1 is required for the transition of Wnt signaling from me... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16678815 Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. |
| GO:0005634 nucleus | IDA PMID:16858399 C3G regulates the size of the cerebral cortex neural precurs... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16858399 C3G regulates the size of the cerebral cortex neural precursor population. |
| GO:0005634 nucleus | IDA PMID:16989802 Levels of mesenchymal FGFR2 signaling modulate smooth muscle... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16989802 Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. |
| GO:0005634 nucleus | IDA PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla developme... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla development. |
| GO:0005634 nucleus | IDA PMID:17560563 Fgf10 dosage is critical for the amplification of epithelial... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:17560563 Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. |
| GO:0005634 nucleus | IDA PMID:17596282 Unique mechanisms of growth regulation and tumor suppression... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:17596282 Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. |
| GO:0005634 nucleus | IDA PMID:17615359 Regulation of spontaneous intestinal tumorigenesis through t... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:17615359 Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. |
| GO:0005634 nucleus | IDA PMID:18978355 Overexpression of TEAD-1 in transgenic mouse striated muscle... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:18978355 Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. |
| GO:0005634 nucleus | IDA PMID:19213727 Wnt11 promotes osteoblast maturation and mineralization thro... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:19213727 Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. |
| GO:0005634 nucleus | IDA PMID:19497282 Wnt7a activates the planar cell polarity pathway to drive th... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:19497282 Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. |
| GO:0005634 nucleus | IDA PMID:19796622 Uncovering early response of gene regulatory networks in ESC... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:19796622 Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. |
| GO:0005634 nucleus | IDA PMID:19850029 A critical role for sFRP proteins in maintaining caudal neur... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:19850029 A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. |
| GO:0005634 nucleus | IDA PMID:21991325 RSPO1/Ξ²-catenin signaling pathway regulates oogonia differen... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:21991325 RSPO1/Ξ²-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. |
| GO:0005634 nucleus | IDA PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt sig... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. |
| GO:0005634 nucleus | IDA PMID:23266329 Kruppel-like factor 5 controls villus formation and initiati... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:23266329 Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. |
| GO:0005634 nucleus | IDA PMID:23610556 A positive feedback loop involving Gcm1 and Fzd5 directs cho... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:23610556 A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. |
| GO:0005634 nucleus | IDA PMID:23740243 Activation of the transcription factor GLI1 by WNT signaling... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:23740243 Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. |
| GO:0005634 nucleus | IDA PMID:25535395 Notch inhibition induces mitotically generated hair cells in... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:25535395 Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. |
| GO:0005634 nucleus | IDA PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage deg... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
| GO:0005634 nucleus | IDA PMID:31222549 The Shisa3 knockout mouse exhibits normal bone phenotype. | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:31222549 The Shisa3 knockout mouse exhibits normal bone phenotype. |
| GO:0005667 transcription regulator complex | IDA PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway m... | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. Supporting Evidence: PMID:12464179 Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. |
| GO:0005667 transcription regulator complex | IDA PMID:12861022 T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, s... | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. Supporting Evidence: PMID:12861022 T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. |
| GO:0005667 transcription regulator complex | IDA PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. |
| GO:0005737 cytoplasm | IPI PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage deg... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
| GO:0005737 cytoplasm | IDA PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin ... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. |
| GO:0005737 cytoplasm | IDA PMID:11731265 Expression of Tcf/Lef and sFrp and localization of beta-cate... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:11731265 Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung. |
| GO:0005737 cytoplasm | IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. |
| GO:0005737 cytoplasm | IDA PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP recepto... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:12923052 Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. |
| GO:0005737 cytoplasm | IDA PMID:14981260 Nuclear-cytoplasmic shuttling of Axin regulates subcellular ... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:14981260 Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. |
| GO:0005737 cytoplasm | IDA PMID:15525667 Stabilization of beta-catenin in the mouse zygote leads to p... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15525667 Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. |
| GO:0005737 cytoplasm | IDA PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:15574752 Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. |
| GO:0005737 cytoplasm | IDA PMID:16489008 Patched1 functions as a gatekeeper by promoting cell cycle p... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:16489008 Patched1 functions as a gatekeeper by promoting cell cycle progression. |
| GO:0005737 cytoplasm | IDA PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla developme... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:17128274 Wnt-beta-catenin signaling initiates taste papilla development. |
| GO:0005737 cytoplasm | IDA PMID:19213727 Wnt11 promotes osteoblast maturation and mineralization thro... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:19213727 Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. |
| GO:0005737 cytoplasm | IDA PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage deg... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30659184 Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
| GO:0005829 cytosol | IDA PMID:12055200 Regulation of Wnt signaling during adipogenesis. | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. Supporting Evidence: PMID:12055200 Regulation of Wnt signaling during adipogenesis. |
| GO:0005829 cytosol | IDA PMID:15673614 Wnt10b deficiency promotes coexpression of myogenic and adip... | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. Supporting Evidence: PMID:15673614 Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. |
| GO:0005886 plasma membrane | IDA PMID:12040017 Mouse mammary epithelial cells express the Na-K-Cl cotranspo... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:12040017 Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. |
| GO:0005886 plasma membrane | IDA PMID:16418220 Desmocollin 3 is required for pre-implantation development o... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:16418220 Desmocollin 3 is required for pre-implantation development of the mouse embryo. |
| GO:0005886 plasma membrane | IDA PMID:16740478 Apc tumor suppressor gene is the "zonation-keeper" of mouse ... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:16740478 Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. |
| GO:0005886 plasma membrane | IDA PMID:16858399 C3G regulates the size of the cerebral cortex neural precurs... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:16858399 C3G regulates the size of the cerebral cortex neural precursor population. |
| GO:0005886 plasma membrane | IDA PMID:16962386 Tissue, cellular and sub-cellular localization of the Vangl2... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:16962386 Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. |
| GO:0005886 plasma membrane | IDA PMID:17596282 Unique mechanisms of growth regulation and tumor suppression... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:17596282 Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. |
| GO:0005886 plasma membrane | IDA PMID:19966784 Sec24b selectively sorts Vangl2 to regulate planar cell pola... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:19966784 Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. |
| GO:0005886 plasma membrane | IDA PMID:23266329 Kruppel-like factor 5 controls villus formation and initiati... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:23266329 Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. |
| GO:0005886 plasma membrane | IDA PMID:8853988 Expression and cell membrane localization of catenins during... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:8853988 Expression and cell membrane localization of catenins during mouse preimplantation development. |
| GO:0005911 cell-cell junction | IDA PMID:12181493 TCL1 participates in early embryonic development and is over... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:12181493 TCL1 participates in early embryonic development and is overexpressed in human seminomas. |
| GO:0005911 cell-cell junction | IDA PMID:14597196 Overexpression of Sonic Hedgehog suppresses embryonic hair f... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:14597196 Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. |
| GO:0005911 cell-cell junction | IDA PMID:18816447 Diverse roles of E-cadherin in the morphogenesis of the subm... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:18816447 Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. |
| GO:0005911 cell-cell junction | ISO PMID:19151727 Regulation of cardiovascular development and integrity by th... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:19151727 Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. |
| GO:0005911 cell-cell junction | IDA PMID:20089884 Milk secretion and ejection are impaired in the mammary glan... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:20089884 Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. |
| GO:0005911 cell-cell junction | IDA PMID:21377456 Grainyhead-like 2 regulates neural tube closure and adhesion... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:21377456 Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. |
| GO:0005911 cell-cell junction | IDA PMID:24191021 Sox9 plays multiple roles in the lung epithelium during bran... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:24191021 Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. |
| GO:0005911 cell-cell junction | IDA PMID:9950951 Nuclear localization of beta-catenin and loss of apical brus... | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:9950951 Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. |
| GO:0005912 adherens junction | IDA PMID:11731229 FAM deubiquitylating enzyme is essential for preimplantation... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:11731229 FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:12203715 Localization of the novel Xin protein to the adherens juncti... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:12203715 Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:12695331 NF2 deficiency promotes tumorigenesis and metastasis by dest... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:12695331 NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell resp... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:15148305 Mammalian Fat1 cadherin regulates actin dynamics and cell-ce... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:15148305 Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:15292239 Defects in cell adhesion and the visceral endoderm following... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:15292239 Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:15645444 Gene expression profile analysis of mouse colon embryonic de... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:15645444 Gene expression profile analysis of mouse colon embryonic development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:15775979 E-cadherin is essential for in vivo epidermal barrier functi... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:15775979 E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:16199027 Vezatin, a protein associated to adherens junctions, is requ... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:16199027 Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:16892058 The Rho-GTPase cdc42 regulates neural progenitor fate at the... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:16892058 The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:17544522 Targeted disruption of the murine large nuclear KIAA1440/Int... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:17544522 Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:21991385 Adhesion protein VSIG1 is required for the proper differenti... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:21991385 Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is e... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:23824574 Wnt/Ξ²-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:26787558 SPECC1L deficiency results in increased adherens junction st... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:26787558 SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005912 adherens junction | IDA PMID:29211732 The mouse Jhy gene regulates ependymal cell differentiation ... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:29211732 The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005916 fascia adherens | IDA PMID:16481394 The transitional junction: a new functional subcellular doma... | ACCEPT | Summary: Beta-catenin is a core structural component of the fascia adherens, linking N-cadherin to actin at cardiac intercalated-disc junctions (IDA); a direct adhesion-structure localization. Reason: direct structural localization at adherens junction Supporting Evidence: PMID:16481394 The transitional junction: a new functional subcellular domain at the intercalated disc. |
| GO:0005923 bicellular tight junction | IDA PMID:17130295 Distinct subdomain organization and molecular composition of... | KEEP AS NON CORE | Summary: Beta-catenin is detected near tight junctions through junctional crosstalk, but tight junctions are not its primary structural site (adherens junctions are). Reason: Adjacent-junction localization; IDA but non-core. Supporting Evidence: PMID:17130295 Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. |
| GO:0014704 intercalated disc | IDA PMID:17535849 A unique and specific interaction between alphaT-catenin and... | ACCEPT | Summary: Beta-catenin is a core structural component of the cardiac intercalated disc, anchoring N-cadherin to the actin cytoskeleton (IDA/ISO); a direct adhesion-structure localization. Reason: direct structural localization at cardiac junction Supporting Evidence: PMID:17535849 A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. |
| GO:0016020 membrane | IDA PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin ... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:11731231 Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. |
| GO:0016020 membrane | IDA PMID:12055200 Regulation of Wnt signaling during adipogenesis. | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:12055200 Regulation of Wnt signaling during adipogenesis. |
| GO:0016020 membrane | IDA PMID:12432063 Protein kinase CKII regulates the interaction of beta-cateni... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:12432063 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. |
| GO:0016020 membrane | IDA PMID:12611902 Regulation of the SHP-2 tyrosine phosphatase by a novel chol... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:12611902 Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. |
| GO:0016020 membrane | IDA PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell resp... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. |
| GO:0016020 membrane | IDA PMID:15987773 Forkhead box A1 regulates prostate ductal morphogenesis and ... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:15987773 Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. |
| GO:0016020 membrane | IDA PMID:16364283 Hex homeobox gene controls the transition of the endoderm to... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:16364283 Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. |
| GO:0016020 membrane | IDA PMID:21991325 RSPO1/Ξ²-catenin signaling pathway regulates oogonia differen... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:21991325 RSPO1/Ξ²-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. |
| GO:0016020 membrane | IDA PMID:22139371 Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals ... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:22139371 Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. |
| GO:0016020 membrane | IDA PMID:8821035 Expression of catenins during mouse embryonic development an... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:8821035 Expression of catenins during mouse embryonic development and in adult tissues. |
| GO:0016323 basolateral plasma membrane | IDA PMID:12885771 beta-Catenin is required for specification of proximal/dista... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:12885771 beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. |
| GO:0016323 basolateral plasma membrane | IDA PMID:14625387 Foxj1 is required for apical localization of ezrin in airway... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:14625387 Foxj1 is required for apical localization of ezrin in airway epithelial cells. |
| GO:0016323 basolateral plasma membrane | IDA PMID:15226261 Orpk mouse model of polycystic kidney disease reveals essent... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:15226261 Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. |
| GO:0016323 basolateral plasma membrane | IDA PMID:17671182 Haploinsufficiency of KrΓΌppel-like factor 4 promotes adenoma... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:17671182 Haploinsufficiency of KrΓΌppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. |
| GO:0016323 basolateral plasma membrane | IDA PMID:20016102 The small GTPase Rac1 regulates auditory hair cell morphogen... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:20016102 The small GTPase Rac1 regulates auditory hair cell morphogenesis. |
| GO:0016323 basolateral plasma membrane | IDA PMID:20089884 Milk secretion and ejection are impaired in the mammary glan... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:20089884 Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. |
| GO:0016323 basolateral plasma membrane | IDA PMID:9950951 Nuclear localization of beta-catenin and loss of apical brus... | ACCEPT | Summary: Beta-catenin localizes to the basolateral membrane domain of epithelia, the site of cadherin-based cell-cell contacts. Reason: Genuine junctional pool; IDA-supported. Supporting Evidence: PMID:9950951 Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. |
| GO:0016327 apicolateral plasma membrane | IDA PMID:29211732 The mouse Jhy gene regulates ependymal cell differentiation ... | ACCEPT | Summary: Beta-catenin concentrates at the apicolateral membrane where adherens junctions form between polarized epithelial cells. Reason: Genuine junctional membrane localization; IDA. Supporting Evidence: PMID:29211732 The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis. |
| GO:0016328 lateral plasma membrane | ISO GO_REF:0000008 | ACCEPT | Summary: Beta-catenin concentrates at the lateral membrane of epithelia where cadherin-based cell-cell junctions assemble. Reason: Genuine core junctional membrane pool; IDA. |
| GO:0016328 lateral plasma membrane | IDA PMID:15645444 Gene expression profile analysis of mouse colon embryonic de... | ACCEPT | Summary: Beta-catenin concentrates at the lateral membrane of epithelia where cadherin-based cell-cell junctions assemble. Reason: Genuine core junctional membrane pool; IDA. Supporting Evidence: PMID:15645444 Gene expression profile analysis of mouse colon embryonic development. |
| GO:0016342 catenin complex | IDA PMID:8853988 Expression and cell membrane localization of catenins during... | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). Supporting Evidence: PMID:8853988 Expression and cell membrane localization of catenins during mouse preimplantation development. |
| GO:0030018 Z disc | IDA PMID:8821035 Expression of catenins during mouse embryonic development an... | KEEP AS NON CORE | Summary: Beta-catenin localizes to the cardiomyocyte Z disc/intercalated-disc region, a muscle-specific adhesion structure secondary to its general adherens-junction role. Reason: Tissue-specific (muscle) localization; IDA but non-core. Supporting Evidence: PMID:8821035 Expression of catenins during mouse embryonic development and in adult tissues. |
| GO:0030027 lamellipodium | IDA PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell resp... | KEEP AS NON CORE | Summary: A lamellipodial pool reflects beta-catenin at dynamic actin-rich protrusions, secondary to its stable junctional localization. Reason: Context-specific localization; IDA, non-core. Supporting Evidence: PMID:14657280 Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. |
| GO:0030877 beta-catenin destruction complex | IDA PMID:10318824 Functional domains of axin. Importance of the C terminus as ... | ACCEPT | Summary: In the absence of Wnt, beta-catenin is the substrate within the AXIN/APC/GSK3B/CK1 destruction complex that drives its phosphorylation and degradation. Reason: Core Wnt regulation; defining complex membership (IDA/ISS). Supporting Evidence: PMID:10318824 Functional domains of axin. Importance of the C terminus as an oligomerization domain. |
| GO:0031253 cell projection membrane | IDA PMID:16621792 Membrane localization of adenomatous polyposis coli protein ... | KEEP AS NON CORE | Summary: Localization to cell-projection membranes (e.g. neuronal processes) is a specialized pool secondary to beta-catenin's epithelial junction role. Reason: Context-specific membrane pool; IDA but peripheral. Supporting Evidence: PMID:16621792 Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. |
| GO:0031528 microvillus membrane | IDA PMID:16439479 Foxf1 and Foxf2 control murine gut development by limiting m... | KEEP AS NON CORE | Summary: A microvillus-membrane pool is a specialized apical localization in particular epithelia, secondary to core junctional pools. Reason: Tissue-specific localization; IDA, non-core. Supporting Evidence: PMID:16439479 Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. |
| GO:0032991 protein-containing complex | ISO PMID:22083958 Histone H1 recruitment by CHD8 is essential for suppression ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein-containing complex' is uninformative; beta-catenin's specific complexes (catenin, TCF, destruction) are annotated separately. Reason: Generic CC over-annotation. Supporting Evidence: PMID:22083958 Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-Ξ²-catenin signaling pathway. |
| GO:0043296 apical junction complex | IDA PMID:16249236 Shroom regulates epithelial cell shape via the apical positi... | ACCEPT | Summary: Beta-catenin is a component of the epithelial apical junction complex via the cadherin-catenin adhesion system. Reason: Core epithelial junction localization; IDA. Supporting Evidence: PMID:16249236 Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. |
| GO:0043296 apical junction complex | IDA PMID:17130295 Distinct subdomain organization and molecular composition of... | ACCEPT | Summary: Beta-catenin is a component of the epithelial apical junction complex via the cadherin-catenin adhesion system. Reason: Core epithelial junction localization; IDA. Supporting Evidence: PMID:17130295 Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. |
| GO:0043296 apical junction complex | IDA PMID:17666436 Shroom2, a myosin-VIIa- and actin-binding protein, directly ... | ACCEPT | Summary: Beta-catenin is a component of the epithelial apical junction complex via the cadherin-catenin adhesion system. Reason: Core epithelial junction localization; IDA. Supporting Evidence: PMID:17666436 Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. |
| GO:0045177 apical part of cell | IDA PMID:14758363 The hyh mutation uncovers roles for alpha Snap in apical pro... | ACCEPT | Summary: Beta-catenin localizes apically in polarized epithelia where adherens junctions concentrate near the apical pole. Reason: Genuine epithelial pool; IDA-supported. Supporting Evidence: PMID:14758363 The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. |
| GO:0045177 apical part of cell | IDA PMID:15037549 Loss of cell polarity causes severe brain dysplasia in Lgl1 ... | ACCEPT | Summary: Beta-catenin localizes apically in polarized epithelia where adherens junctions concentrate near the apical pole. Reason: Genuine epithelial pool; IDA-supported. Supporting Evidence: PMID:15037549 Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. |
| GO:0045177 apical part of cell | IDA PMID:16249236 Shroom regulates epithelial cell shape via the apical positi... | ACCEPT | Summary: Beta-catenin localizes apically in polarized epithelia where adherens junctions concentrate near the apical pole. Reason: Genuine epithelial pool; IDA-supported. Supporting Evidence: PMID:16249236 Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. |
| GO:0045177 apical part of cell | IDA PMID:23863479 Tumor suppressor Nf2 limits expansion of the neural progenit... | ACCEPT | Summary: Beta-catenin localizes apically in polarized epithelia where adherens junctions concentrate near the apical pole. Reason: Genuine epithelial pool; IDA-supported. Supporting Evidence: PMID:23863479 Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. |
| GO:0045294 alpha-catenin binding | IDA PMID:12432063 Protein kinase CKII regulates the interaction of beta-cateni... | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. Supporting Evidence: PMID:12432063 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. |
| GO:0045296 cadherin binding | ISO PMID:10330403 Domains of axin involved in protein-protein interactions, Wn... | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: PMID:10330403 Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045296 cadherin binding | IPI PMID:15023525 Ksp-cadherin is a functional cell-cell adhesion molecule rel... | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: PMID:15023525 Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045296 cadherin binding | IPI PMID:15057752 Beta-catenin is temporally regulated during normal liver dev... | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: PMID:15057752 Beta-catenin is temporally regulated during normal liver development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045296 cadherin binding | IPI PMID:8853988 Expression and cell membrane localization of catenins during... | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: PMID:8853988 Expression and cell membrane localization of catenins during mouse preimplantation development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IDA PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events... | ACCEPT | Summary: Beta-catenin directly binds Pol II-specific DNA-binding transcription factors (TCF/LEF) to drive Wnt-responsive transcription. Reason: Core Wnt coactivation; IDA-supported specific TF binding. Supporting Evidence: PMID:16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IDA PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt sig... | ACCEPT | Summary: Beta-catenin directly binds Pol II-specific DNA-binding transcription factors (TCF/LEF) to drive Wnt-responsive transcription. Reason: Core Wnt coactivation; IDA-supported specific TF binding. Supporting Evidence: PMID:22665494 mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. |
| GO:0140677 molecular function activator activity | EXP PMID:21075118 Biochemical and structural characterization of Ξ²-catenin int... | ACCEPT | Summary: Beta-catenin's nuclear role is to act as a transcriptional coactivator (activator) for TCF/LEF factors; this captures its direct molecular-activator function in the Wnt output. Reason: Direct: as a TCF/LEF coactivator it activates a partner's molecular function, a genuine core MF of beta-catenin. Supporting Evidence: PMID:21075118 Biochemical and structural characterization of Ξ²-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1. |
| GO:0021854 hypothalamus development | IMP PMID:32868762 The cellular and molecular landscape of hypothalamic pattern... | KEEP AS NON CORE | Summary: Beta-catenin supports hypothalamic neuronal specification via Wnt-driven transcription; a CNS developmental outcome downstream of signaling. Reason: downstream Wnt-driven hypothalamus development Supporting Evidence: PMID:32868762 The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:32868762 The cellular and molecular landscape of hypothalamic pattern... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:32868762 The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9773219 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9860515 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9860560 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9860569 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9863577 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-9761463 | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. |
| GO:0005634 nucleus | IDA PMID:30389919 ARTS mediates apoptosis and regeneration of the intestinal s... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30389919 ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. |
| GO:0005737 cytoplasm | IDA PMID:30389919 ARTS mediates apoptosis and regeneration of the intestinal s... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:30389919 ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9735211 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9754284 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9793864 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9794042 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9823738 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9824206 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9824277 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0005654 nucleoplasm | TAS Reactome:R-MMU-9824278 | ACCEPT | Summary: Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator. Reason: Genuine nuclear pool; TAS. |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | ACCEPT | Summary: Beta-catenin binds TCF/LEF DNA-binding transcription factors to coactivate Wnt target genes; core to its nuclear Wnt-effector role. Reason: Core Wnt: direct TCF/LEF coactivation (IPI); foundational MF for the transcriptional arm. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0005912 adherens junction | IDA PMID:20399730 The apical complex couples cell fate and cell survival to ce... | ACCEPT | Summary: Beta-catenin is a defining structural component of the adherens junction, bridging E-cadherin to alpha-catenin and the actin cytoskeleton. Reason: Core structural localization; strongly supported (IBA/IDA). Supporting Evidence: PMID:20399730 The apical complex couples cell fate and cell survival to cerebral cortical development. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005886 plasma membrane | IDA PMID:17920587 FERM protein EPB41L5 is a novel member of the mammalian CRB-... | ACCEPT | Summary: The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes. Reason: Core localization; IDA/TAS-supported. Supporting Evidence: PMID:17920587 FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. |
| GO:1990907 beta-catenin-TCF complex | IDA PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | ACCEPT | Summary: The nuclear beta-catenin-TCF complex is the central transcriptional effector unit of canonical Wnt signaling. Reason: Core Wnt effector complex; IDA-supported. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:0032968 positive regulation of transcription elongation by RNA polymerase II | IMP PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in p... | KEEP AS NON CORE | Summary: IMP annotation; beta-catenin can promote elongation (e.g. via TNIK/PAF1c at Wnt targets), a specific mechanistic facet that is secondary to its core coactivator recruitment role. Reason: Specific mechanistic facet; experimental, downgrade not remove. Supporting Evidence: PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in p... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:30478225 TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005515 protein binding | IPI PMID:15110721 Sox1 acts through multiple independent pathways to promote n... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15110721 Sox1 acts through multiple independent pathways to promote neurogenesis. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:15110721 Sox1 acts through multiple independent pathways to promote n... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:15110721 Sox1 acts through multiple independent pathways to promote neurogenesis. |
| GO:0005515 protein binding | IPI PMID:31073040 LMBR1L regulates lymphopoiesis through Wnt/Ξ²-catenin signali... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:31073040 LMBR1L regulates lymphopoiesis through Wnt/Ξ²-catenin signaling. |
| GO:0005911 cell-cell junction | IDA PMID:24338362 POPX2 phosphatase regulates the KIF3 kinesin motor complex. | ACCEPT | Summary: Beta-catenin localizes to cell-cell junctions (adherens junctions) as a structural complex component. Reason: Core junctional localization; IDA. Supporting Evidence: PMID:24338362 POPX2 phosphatase regulates the KIF3 kinesin motor complex. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:15314168 Cyclin D1 genetic heterozygosity regulates colonic epithelia... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:15314168 Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0003713 transcription coactivator activity | IMP PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical ne... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical neurogenesis. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0005634 nucleus | IMP PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical ne... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical neurogenesis. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical ne... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical neurogenesis. |
| GO:0050768 negative regulation of neurogenesis | IMP PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical ne... | KEEP AS NON CORE | Summary: Beta-catenin can suppress neuronal differentiation by maintaining neural progenitors (Wnt stemness targets); a downstream CNS-development phenotype. Reason: Neurogenesis suppression downstream of Wnt progenitor-maintenance transcription. Supporting Evidence: PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical neurogenesis. |
| GO:2000179 positive regulation of neural precursor cell proliferation | IMP PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical ne... | KEEP AS NON CORE | Summary: Beta-catenin enlarges the neural precursor pool by activating Wnt cell-cycle genes; a downstream CNS-development phenotype. Reason: Neural-precursor expansion downstream of Wnt mitogenic targets. Supporting Evidence: PMID:26371318 Lhx2 regulates the timing of Ξ²-catenin-dependent cortical neurogenesis. |
| GO:0003682 chromatin binding | IDA PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | ACCEPT | Summary: In the nucleus beta-catenin associates with chromatin at Wnt target genes as part of TCF/LEF transcription complexes. Reason: Core nuclear Wnt role; IDA/IGI-supported. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:1990907 beta-catenin-TCF complex | IDA PMID:9488439 Two members of the Tcf family implicated in Wnt/beta-catenin... | ACCEPT | Summary: The nuclear beta-catenin-TCF complex is the central transcriptional effector unit of canonical Wnt signaling. Reason: Core Wnt effector complex; IDA-supported. Supporting Evidence: PMID:9488439 Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |
| GO:1990138 neuron projection extension | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred role in axon/dendrite outgrowth, plausibly via cadherin-junction and Wnt-transcriptional inputs; a downstream neuronal phenotype. Reason: Neurite extension downstream of adhesion/Wnt roles; non-core (electronic). |
| GO:0005515 protein binding | IPI PMID:25232112 Dlg5 regulates dendritic spine formation and synaptogenesis ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:25232112 Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. |
| GO:0045202 synapse | IDA PMID:25232112 Dlg5 regulates dendritic spine formation and synaptogenesis ... | KEEP AS NON CORE | Summary: Synaptic localization supports cadherin-based synaptic adhesion in neurons, a tissue-specific pool. Reason: Synapse localization; IDA/IEA, non-core. Supporting Evidence: PMID:25232112 Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. |
| GO:0016525 negative regulation of angiogenesis | IMP PMID:25961718 Resveratrol-Induced Vascular Progenitor Differentiation towa... | KEEP AS NON CORE | Summary: Endothelial Wnt/beta-catenin signaling can restrain vessel sprouting through transcriptional targets; a context-dependent downstream vascular phenotype. Reason: Angiogenesis regulation downstream of endothelial Wnt-transcriptional output. Supporting Evidence: PMID:25961718 Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/Ξ²-Catenin Is Protective in Vessel Graft Models. |
| GO:0005634 nucleus | IDA PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cu... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cutaneous stem cell proliferation. |
| GO:0005737 cytoplasm | IDA PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cu... | ACCEPT | Summary: Beta-catenin maintains a genuine cytoplasmic pool, where it is held in the destruction complex or bound to cadherin tails before junction delivery. Reason: Genuine pool; strongly supported (IDA/IPI). Retain, not REMOVE. Supporting Evidence: PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cutaneous stem cell proliferation. |
| GO:0051884 regulation of timing of anagen | IDA PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cu... | KEEP AS NON CORE | Summary: Beta-catenin Wnt activity initiates the hair-follicle growth (anagen) phase; an IDA developmental-timing phenotype downstream of transcription. Reason: Hair-cycle anagen timing downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cutaneous stem cell proliferation. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cu... | ACCEPT | Summary: The definitional core function: beta-catenin is the key downstream effector of the canonical Wnt pathway, stabilized upon Wnt to drive TCF/LEF target genes. Broadly supported (IDA/IMP/IGI). Reason: Central, multiply-supported core function of the gene. Supporting Evidence: PMID:24681597 Kindlin-1 controls Wnt and TGF-Ξ² availability to regulate cutaneous stem cell proliferation. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0016342 catenin complex | IMP PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absen... | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). Supporting Evidence: PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. |
| GO:0045296 cadherin binding | IPI PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absen... | ACCEPT | Summary: Beta-catenin binds the cytoplasmic tail of classical cadherins (E-/N-cadherin) via its armadillo repeats, the founding interaction of the cadherin-catenin complex. Reason: Core structural MF; crystallographically defined, IPI/IBA. Supporting Evidence: PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0097718 disordered domain specific binding | IPI PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absen... | KEEP AS NON CORE | Summary: Binding to intrinsically disordered regions of partners (e.g. cadherin/APC tails) is a real biophysical mode but a generic descriptor of specific interactions captured elsewhere. Reason: Generic-ish MF; IPI but peripheral to named partner terms. Supporting Evidence: PMID:11121423 The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. |
| GO:0005634 nucleus | IDA PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:0005829 cytosol | IDA PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:0016020 membrane | IDA PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | KEEP AS NON CORE | Summary: Bare 'membrane' is uninformative given the specific plasma-membrane/junction terms already capturing beta-catenin's localization. Reason: Over-general CC parent. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IGI PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav... | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. Supporting Evidence: PMID:20371816 LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. |
| GO:0005634 nucleus | IDA PMID:25979161 Transmembrane protein 64 reciprocally regulates osteoblast a... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:25979161 Transmembrane protein 64 reciprocally regulates osteoblast and adipocyte differentiation by modulating Wnt/Ξ²-catenin signaling. |
| GO:1904948 midbrain dopaminergic neuron differentiation | IMP PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neuro... | KEEP AS NON CORE | Summary: Beta-catenin drives midbrain dopaminergic neuron differentiation via Wnt1/TCF transcription; a neuronal cell-fate outcome downstream of signaling. Reason: downstream Wnt-driven midbrain DA neuron fate Supporting Evidence: PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. |
| GO:0005634 nucleus | IDA PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via Ξ²-catenin. |
| GO:0005829 cytosol | IDA PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via... | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. Supporting Evidence: PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via Ξ²-catenin. |
| GO:0019899 enzyme binding | IPI PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via... | MARK AS OVER ANNOTATED | Summary: Bare 'enzyme binding' is uninformative; beta-catenin's relevant enzyme contacts (GSK3B, CK1, kinases) are captured by specific kinase/phosphatase terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:22645310 Prolyl isomerase Pin1 regulates neuronal differentiation via Ξ²-catenin. |
| GO:1904888 cranial skeletal system development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin patterns craniofacial skeleton via Wnt-driven osteochondral fate decisions; a skeletal developmental outcome, not core function. Reason: downstream Wnt-driven craniofacial skeletogenesis Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:0030901 midbrain development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin patterns midbrain via Wnt/TCF transcription and progenitor control; a CNS developmental outcome, not core function. Reason: downstream Wnt-driven midbrain development Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:0030902 hindbrain development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin patterns hindbrain via Wnt/TCF transcription and progenitor control; a CNS developmental outcome, not core function. Reason: downstream Wnt-driven hindbrain development Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:0061550 cranial ganglion development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin supports cranial ganglion/placode development through Wnt/TCF transcription; a neural-crest/placode outcome downstream of signaling. Reason: downstream Wnt role in cranial ganglion development Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:1990403 embryonic brain development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin supports embryonic brain growth/patterning via Wnt/TCF neural transcription; a CNS developmental outcome, not core function. Reason: downstream Wnt-driven embryonic brain development Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:1990791 dorsal root ganglion development | IMP PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated d... | KEEP AS NON CORE | Summary: Beta-catenin supports DRG formation from neural crest via Wnt/TCF transcription; a peripheral-nervous-system developmental outcome, not core function. Reason: downstream Wnt-driven DRG development Supporting Evidence: PMID:11262227 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. |
| GO:1990909 Wnt signalosome | IDA PMID:22899650 LRRK2 functions as a Wnt signaling scaffold, bridging cytoso... | ACCEPT | Summary: IDA-supported: stabilized beta-catenin is a component of the Wnt signalosome where it escapes destruction-complex phosphorylation. Core to its Wnt-effector role. Reason: Experimental component annotation central to canonical Wnt signaling. Supporting Evidence: PMID:22899650 LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. |
| GO:0019901 protein kinase binding | IPI PMID:22899650 LRRK2 functions as a Wnt signaling scaffold, bridging cytoso... | KEEP AS NON CORE | Summary: Protein-kinase binding reflects regulatory contacts (GSK3B, CK1, CDKs) governing beta-catenin stability; specific destruction-complex terms are more informative. Reason: Semi-generic regulatory MF; IPI, non-core. Supporting Evidence: PMID:22899650 LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. |
| GO:0005515 protein binding | IPI PMID:15908431 MAGI1 recruits Dll1 to cadherin-based adherens junctions and... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:15908431 MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. |
| GO:0010629 negative regulation of gene expression | IMP PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neuro... | MARK AS OVER ANNOTATED | Summary: Generic negative-regulation-of-expression parent; beta-catenin's specific repressive effects act at the level of Pol II transcription of particular targets. Reason: Uninformative broad parent; specific Pol II transcription terms preferred. Supporting Evidence: PMID:19122665 Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. |
| GO:0030182 neuron differentiation | IMP PMID:25009587 Depletion of canonical Wnt signaling components has a neurop... | KEEP AS NON CORE | Summary: Beta-catenin influences neuronal differentiation timing via Wnt-target transcription; a downstream neurodevelopmental process. Reason: Neuronal differentiation downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:25009587 Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease. |
| GO:0016600 flotillin complex | IDA PMID:24046456 Flotillin microdomains stabilize cadherins at cell-cell junc... | KEEP AS NON CORE | Summary: A reported flotillin-complex association reflects a membrane microdomain pool, peripheral to beta-catenin's core junction/Wnt functions. Reason: Specialized complex; IDA but non-core. Supporting Evidence: PMID:24046456 Flotillin microdomains stabilize cadherins at cell-cell junctions. |
| GO:0000791 euchromatin | IDA PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: beta-catenin localizes with active TCF/LEF target loci in euchromatin, consistent with its coactivator role, but this CC term is contextual rather than a core function statement. Reason: Localization term supporting, but not equal to, its coactivator function. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0005667 transcription regulator complex | IDA PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells a... | ACCEPT | Summary: Beta-catenin is a component of transcription regulator complexes (with TCF/LEF and coactivators) that drive Wnt target gene expression. Reason: Core nuclear Wnt effector complex; IDA-supported. Supporting Evidence: PMID:22723415 Wnt/Ξ²-catenin signaling regulates telomerase in stem cells and cancer cells. |
| GO:0002052 positive regulation of neuroblast proliferation | IMP PMID:21325504 Frizzled3 is required for neurogenesis and target innervatio... | KEEP AS NON CORE | Summary: Beta-catenin positively drives neuroblast expansion through Wnt cell-cycle targets; a downstream neurodevelopmental proliferative role. Reason: Pro-neuroblast proliferation downstream of Wnt transcription. Supporting Evidence: PMID:21325504 Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. |
| GO:0045976 negative regulation of mitotic cell cycle, embryonic | IMP PMID:21325504 Frizzled3 is required for neurogenesis and target innervatio... | KEEP AS NON CORE | Summary: Beta-catenin restrains embryonic mitotic cycling in specific contexts via Wnt cell-cycle target genes; a downstream developmental phenotype. Reason: Embryonic cell-cycle restraint downstream of Wnt transcription. Supporting Evidence: PMID:21325504 Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. |
| GO:0061549 sympathetic ganglion development | IMP PMID:21325504 Frizzled3 is required for neurogenesis and target innervatio... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling supports sympathetic neuron lineage development; a downstream peripheral-nervous-system phenotype. Reason: Sympathetic ganglion development downstream of Wnt transcription. Supporting Evidence: PMID:21325504 Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. |
| GO:0005515 protein binding | IPI PMID:23856522 Jmjd3 controls mesodermal and cardiovascular differentiation... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:23856522 Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. |
| GO:0005634 nucleus | IDA PMID:23856522 Jmjd3 controls mesodermal and cardiovascular differentiation... | ACCEPT | Summary: Nuclear accumulation of stabilized beta-catenin is essential for its role as the canonical Wnt transcriptional effector. Reason: Core localization; broadly supported (IDA/IMP/IPI). Retain, not REMOVE. Supporting Evidence: PMID:23856522 Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. |
| GO:0016922 nuclear receptor binding | IPI PMID:14687547 RORalpha coordinates reciprocal signaling in cerebellar deve... | KEEP AS NON CORE | Summary: Beta-catenin coactivates several nuclear receptors (e.g. NR5A2, AR/ER), broadening its transcriptional crosstalk beyond the core TCF/LEF axis. Reason: Crosstalk coactivation; non-core relative to TCF. Supporting Evidence: PMID:14687547 RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. |
| GO:0033234 negative regulation of protein sumoylation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred negative effect on SUMOylation; an indirect downstream activity unrelated to beta-catenin's core adhesion/Wnt functions. Reason: SUMOylation suppression, electronic-inferred and indirect; non-core. |
| GO:0048643 positive regulation of skeletal muscle tissue development | IMP PMID:23460868 Ξ²-catenin is essential for efficient in vitro premyogenic me... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling supports skeletal muscle tissue formation by driving myogenic gene programs; a downstream tissue-development role. Reason: Skeletal muscle development downstream of Wnt/beta-catenin transcription. Supporting Evidence: PMID:23460868 Ξ²-catenin is essential for efficient in vitro premyogenic mesoderm formation but can be partially compensated by retinoic acid signalling. |
| GO:0005515 protein binding | IPI PMID:11590244 alphaT-catenin: a novel tissue-specific beta-catenin-binding... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:11590244 alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. |
| GO:0036023 embryonic skeletal limb joint morphogenesis | IGI PMID:21262216 The zinc finger transcription factors Osr1 and Osr2 control ... | KEEP AS NON CORE | Summary: Beta-catenin specifies limb joint interzones via Wnt/TCF transcription (IGI); a skeletal morphogenetic outcome downstream of its signaling role. Reason: downstream Wnt-driven limb joint morphogenesis Supporting Evidence: PMID:21262216 The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. |
| GO:0045294 alpha-catenin binding | IPI PMID:21393547 A polarized epithelium organized by beta- and alpha-catenin ... | ACCEPT | Summary: Beta-catenin binds alpha-catenin via its N-terminal region, the key linkage coupling the cadherin-catenin complex to the actin cytoskeleton. Reason: Core structural MF; crystallographically defined, IPI/IDA. Supporting Evidence: PMID:21393547 A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. |
| GO:0005515 protein binding | IPI PMID:18636119 Coxsackievirus and adenovirus receptor (CAR) mediates atriov... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:18636119 Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. |
| GO:0072182 regulation of nephron tubule epithelial cell differentiation | IMP PMID:19112489 Gata3 acts downstream of beta-catenin signaling to prevent e... | KEEP AS NON CORE | Summary: Beta-catenin tunes nephron epithelial cell fate during kidney development via Wnt targets; a downstream renal phenotype. Reason: Nephron epithelial differentiation control downstream of Wnt transcription. Supporting Evidence: PMID:19112489 Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:19112489 Gata3 acts downstream of beta-catenin signaling to prevent e... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:19112489 Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. |
| GO:0071944 cell periphery | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin localizes to the cell periphery at adherens junctions linking cadherins to actin; a broad location term consistent with its structural role but less specific than the junction terms. Reason: electronic broad location subsumed by adherens-junction terms |
| GO:0005938 cell cortex | ISS GO_REF:0000024 | ACCEPT | Summary: Beta-catenin associates with the actin-rich cell cortex via the cadherin-catenin complex at cell-cell contacts. Reason: Genuine cortical pool at junctions. |
| GO:0007155 cell adhesion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Generic cell adhesion is subsumed by the more specific cadherin-mediated cell-cell adhesion terms that capture beta-catenin's actual mechanism. Reason: Over-general parent; electronic; specific child preferred. |
| GO:0008285 negative regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Electronic/ortholog-inferred anti-proliferative effect in some lineages, downstream of context-specific Wnt transcriptional output. Reason: Context anti-proliferation downstream of transcription; non-core (electronic). |
| GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred up-regulation of HSPG biosynthesis, plausibly via Wnt transcriptional targets; a downstream biosynthetic effect. Reason: HSPG biosynthesis upregulation downstream of transcription; non-core (electronic). |
| GO:0016342 catenin complex | ISS GO_REF:0000024 | ACCEPT | Summary: Beta-catenin is a defining member of the catenin (cadherin-catenin) complex linking cadherins to alpha-catenin/actin. Reason: Core complex; broadly supported (IBA/IDA/IMP/ISS). |
| GO:0030054 cell junction | ISS GO_REF:0000024 | ACCEPT | Summary: Beta-catenin is a core cell-junction protein, concentrated at cadherin-based cell-cell junctions. Reason: Core localization (junction parent). |
| GO:0030877 beta-catenin destruction complex | ISS GO_REF:0000024 | ACCEPT | Summary: In the absence of Wnt, beta-catenin is the substrate within the AXIN/APC/GSK3B/CK1 destruction complex that drives its phosphorylation and degradation. Reason: Core Wnt regulation; defining complex membership (IDA/ISS). |
| GO:0030997 regulation of centriole-centriole cohesion | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal moonlighting role in centriole cohesion; ortholog/electronic-inferred and distinct from its core adhesion/Wnt roles. Reason: Centrosomal moonlighting role, electronic-inferred; non-core. |
| GO:0032355 response to estradiol | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred responsiveness to estradiol, reflecting hormone crosstalk with Wnt/beta-catenin transcription in reproductive tissues; a downstream response. Reason: Estradiol response downstream/crosstalk with Wnt transcription; non-core (electronic). |
| GO:0032993 protein-DNA complex | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin is part of protein-DNA complexes only indirectly via TCF/LEF; the specific beta-catenin-TCF complex terms capture this better. Reason: Indirect/over-general; electronic. |
| GO:0034333 adherens junction assembly | ISS GO_REF:0000024 | ACCEPT | Summary: By linking cadherin to the catenin/actin machinery, beta-catenin is required for adherens junction assembly. Reason: Core adhesion process; mechanistically central even if evidence is electronic/ISS. |
| GO:0034394 protein localization to cell surface | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin promotes surface delivery/retention of cadherin (e.g. via vinculin), a supporting trafficking role secondary to its structural function. Reason: Peripheral process; electronic. |
| GO:0043065 positive regulation of apoptotic process | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: In some contexts beta-catenin promotes apoptosis; this electronic/ortholog-inferred bidirectional effect is a downstream consequence of context-specific transcription. Reason: Context-dependent pro-apoptotic output downstream of transcription; non-core (electronic). |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: Core function: nuclear beta-catenin is the TCF/LEF coactivator that activates Wnt-responsive Pol II target genes (recruits EP300/CREBBP, BCL9). Broadly supported. Reason: Central coactivator function, multiply and experimentally supported. |
| GO:0048471 perinuclear region of cytoplasm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: A perinuclear cytoplasmic pool may reflect shuttling/staging intermediates, secondary to functional junctional and nuclear pools. Reason: Secondary localization; electronic. |
| GO:0048660 regulation of smooth muscle cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Modulation of vascular/visceral smooth muscle proliferation reflects Wnt/beta-catenin mitogenic target genes; ortholog/electronic-inferred downstream process. Reason: Downstream proliferative control via Wnt transcriptional targets; non-core. |
| GO:0061154 endothelial tube morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin supports endothelial tube formation via junctional integrity and Wnt transcription; a vascular morphogenetic outcome (electronic) downstream of its dual role. Reason: electronic; downstream of junction/Wnt vascular roles |
| GO:0070369 beta-catenin-TCF7L2 complex | ISS GO_REF:0000024 | ACCEPT | Summary: Beta-catenin forms the specific transcriptional complex with TCF7L2/TCF4 that activates Wnt target genes. Reason: Core Wnt effector complex (specific TCF member). |
| GO:0071363 cellular response to growth factor stimulus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin participates in growth-factor-responsive transcription via Wnt crosstalk; a broad, electronically inferred response, kept as non-core given indirect linkage. Reason: electronic/generic; indirect crosstalk, not core |
| GO:0071681 cellular response to indole-3-methanol | ISS GO_REF:0000024 | REMOVE | Summary: No credible biological basis for beta-catenin as a responder to indole-3-methanol; an electronically propagated (IEA/ISO/ISS) annotation with no support. Reason: electronic annotation biologically unsupported for this gene |
| GO:0090279 regulation of calcium ion import | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Ortholog/electronic-inferred influence on calcium import, distinct from beta-catenin's core Wnt/adhesion roles; a downstream/indirect effect. Reason: Calcium-import regulation, electronic-inferred and indirect; non-core. |
| GO:2000008 regulation of protein localization to cell surface | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Beta-catenin modulates cadherin surface levels, a regulatory trafficking role secondary to its structural junction function. Reason: Peripheral regulatory process; electronic. |
| GO:0005515 protein binding | IPI PMID:20802155 Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional ... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:20802155 Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. |
| GO:0034750 Scrib-APC-beta-catenin complex | IDA PMID:16611247 Human scribble, a novel tumor suppressor identified as a tar... | KEEP AS NON CORE | Summary: Beta-catenin participates in a Scrib-APC complex linked to synaptic vesicle localization and polarity, a specialized assembly beyond core adhesion/Wnt complexes. Reason: Specialized complex (IDA); peripheral, neuronal-polarity context. Supporting Evidence: PMID:16611247 Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. |
| GO:0005813 centrosome | IDA PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohe... | KEEP AS NON CORE | Summary: Beta-catenin has a reported centrosomal pool acting in centrosome cohesion/separation, distinct from its core adhesion and Wnt roles. Reason: Secondary localization; IDA but non-core moonlighting. Supporting Evidence: PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohesion. |
| GO:0070602 regulation of centromeric sister chromatid cohesion | IMP PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohe... | KEEP AS NON CORE | Summary: A reported beta-catenin role at centromeric cohesion is a moonlighting function separate from its Wnt/adhesion core; supported by IMP plus electronic inference. Reason: Sister-chromatid cohesion moonlighting role; non-core to Wnt/adhesion. Supporting Evidence: PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohesion. |
| GO:0003713 transcription coactivator activity | IDA PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature a... | ACCEPT | Summary: The core molecular function: nuclear beta-catenin acts as a transcription coactivator for TCF/LEF factors, bridging EP300/CREBBP and BCL9 to Wnt target promoters. Experimentally supported. Reason: Defining molecular-function of beta-catenin; well supported (IDA/IMP). Supporting Evidence: PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. file:mouse/Ctnnb1/Ctnnb1-deep-research.md Beta-catenin is a multifunctional protein with dual roles in cell adhesion and Wnt signaling |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature a... | MODIFY | Summary: Correct in essence but uses the generic DNA-templated parent; beta-catenin specifically positively regulates RNA polymerase II transcription as the TCF/LEF coactivator. Reason: Generic parent; specialize to Pol II-specific positive regulation. Proposed replacements: positive regulation of transcription by RNA polymerase II Supporting Evidence: PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. |
| GO:0005515 protein binding | IPI PMID:20413591 The TRPV4 channel contributes to intercellular junction form... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:20413591 The TRPV4 channel contributes to intercellular junction formation in keratinocytes. |
| GO:0003223 ventricular compact myocardium morphogenesis | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin Wnt signaling contributes to compact-layer ventricular wall formation; a TAS downstream cardiac-morphogenesis phenotype. Reason: Compact myocardium morphogenesis downstream of Wnt transcription (TAS). Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Nuclear beta-catenin drives EMT transcriptional programs (Snail/Twist targets) while loss of its junctional pool also promotes EMT; the process is downstream of both core roles. Reason: EMT is a transcriptional/adhesion downstream output, not beta-catenin's direct molecular function. Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0060038 cardiac muscle cell proliferation | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin supports cardiomyocyte proliferation via Wnt/TCF transcription; a cardiac-growth outcome downstream of its signaling effector role (TAS). Reason: downstream Wnt-driven cardiomyocyte proliferation Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0060485 mesenchyme development | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin supports mesenchymal tissue development via Wnt-driven transcription; a connective-tissue developmental outcome (TAS) downstream of signaling. Reason: downstream Wnt-driven mesenchyme development Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0060947 cardiac vascular smooth muscle cell differentiation | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin promotes cardiac vascular SMC differentiation through Wnt-driven transcription; a cardiovascular cell-fate outcome, not core function (TAS). Reason: downstream Wnt-driven cardiac SMC fate Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0060982 coronary artery morphogenesis | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin shapes coronary artery formation via epicardial/endothelial Wnt transcription; a cardiovascular morphogenetic outcome (TAS), not core function. Reason: downstream Wnt-driven coronary morphogenesis Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin drives epicardium-derived SMC differentiation through Wnt transcription; a cardiovascular cell-fate outcome (TAS), not core function. Reason: downstream Wnt-driven epicardial SMC fate Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0072132 mesenchyme morphogenesis | TAS PMID:20299672 Epicardial-myocardial signaling directing coronary vasculoge... | KEEP AS NON CORE | Summary: Beta-catenin shapes mesenchymal tissue morphogenesis via Wnt transcription and adhesion; a morphogenetic outcome (TAS) of its dual role. Reason: downstream of Wnt/adhesion mesenchyme morphogenesis Supporting Evidence: PMID:20299672 Epicardial-myocardial signaling directing coronary vasculogenesis. |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:17331723 Inhibitory Gli3 activity negatively regulates Wnt/beta-caten... | ACCEPT | Summary: Beta-catenin binds TCF/LEF DNA-binding transcription factors to coactivate Wnt target genes; core to its nuclear Wnt-effector role. Reason: Core Wnt: direct TCF/LEF coactivation (IPI); foundational MF for the transcriptional arm. Supporting Evidence: PMID:17331723 Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. |
| GO:0005515 protein binding | IPI PMID:16611247 Human scribble, a novel tumor suppressor identified as a tar... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:16611247 Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. |
| GO:0005515 protein binding | IPI PMID:19458197 Scribble interacts with beta-catenin to localize synaptic ve... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:19458197 Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. |
| GO:0005515 protein binding | IPI PMID:10954424 The mammalian homologue of the Caenorhabditis elegans polari... | MARK AS OVER ANNOTATED | Summary: Bare 'protein binding' is uninformative; beta-catenin's meaningful interactions are captured by specific cadherin/alpha-catenin/TCF binding terms. Reason: Generic MF over-annotation. Supporting Evidence: PMID:10954424 The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. |
| GO:0019903 protein phosphatase binding | IPI PMID:16973135 Intracellular substrates of brain-enriched receptor protein ... | KEEP AS NON CORE | Summary: Protein-phosphatase binding (e.g. PTPN6/PTPRJ) regulates tyrosine-phosphorylation of junctional beta-catenin, a regulatory interaction. Reason: Regulatory partner; IBA/IPI, non-core. Supporting Evidence: PMID:16973135 Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). |
| GO:0005829 cytosol | TAS Reactome:R-MMU-209096 | ACCEPT | Summary: Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization. Reason: Genuine pool; IDA/TAS-supported. |
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Download this section (compressed HTML)Q: How does Ξ²-catenin coordinate its dual roles in cell adhesion and Wnt signaling, and what mechanisms prevent crosstalk?
Q: What determines the tissue-specific requirements for Ξ²-catenin in development versus homeostasis?
Q: How do different Ξ²-catenin mutations lead to distinct developmental disorders and cancer types?
Q: What role does Ξ²-catenin play in stem cell maintenance and differentiation across different tissue types?
Experiment: Single-cell RNA sequencing of tissues with conditional Ξ²-catenin knockout to map cell-type-specific transcriptional programs
Experiment: Super-resolution microscopy to study Ξ²-catenin dynamics between adherens junctions and the nucleus during Wnt signaling
Experiment: Cryo-EM structural determination of Ξ²-catenin in complex with different binding partners like cadherins and TCF/LEF
Experiment: Lineage tracing in mouse models to study Ξ²-catenin function in stem cell fate decisions during development and regeneration
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Download this section (compressed HTML)π View Pathway Visualization Interactive pathway diagram with detailed annotations