Dnajb11

UniProt ID: Q99KV1
Organism: Mus musculus
Review Status: DRAFT
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Gene Description

TODO: Add description for Dnajb11

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005783 endoplasmic reticulum
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IBA
GO_REF:0000033 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0051604 protein maturation
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: protein maturation is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051787 misfolded protein binding
IBA
GO_REF:0000033 		ACCEPT
Summary: Manual review: misfolded protein binding is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005788 endoplasmic reticulum lumen
IEA
GO_REF:0000044 		ACCEPT
Summary: Manual review: endoplasmic reticulum lumen is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0006457 protein folding
IEA
GO_REF:0000002 		ACCEPT
Summary: Manual review: protein folding is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051082 unfolded protein binding
IEA
GO_REF:0000002 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0005515 protein binding
IPI
PMID:21217698
Substrate discrimination of the chaperone BiP by autonomous ... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for Dnajb11.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0005783 endoplasmic reticulum
ISO
GO_REF:0000119 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0032781 positive regulation of ATP-dependent activity
ISO
GO_REF:0000119 		ACCEPT
Summary: Manual review: positive regulation of ATP-dependent activity is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034663 endoplasmic reticulum chaperone complex
ISO
GO_REF:0000096 		ACCEPT
Summary: Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051604 protein maturation
ISO
GO_REF:0000119 		ACCEPT
Summary: Manual review: protein maturation is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051787 misfolded protein binding
ISO
GO_REF:0000119 		ACCEPT
Summary: Manual review: misfolded protein binding is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0101031 protein folding chaperone complex
ISO
GO_REF:0000119 		ACCEPT
Summary: Manual review: protein folding chaperone complex is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005783 endoplasmic reticulum
IEA
GO_REF:0000107 		ACCEPT
Summary: Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0034663 endoplasmic reticulum chaperone complex
IEA
GO_REF:0000107 		ACCEPT
Summary: Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051604 protein maturation
IEA
GO_REF:0000107 		ACCEPT
Summary: Manual review: protein maturation is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051787 misfolded protein binding
IEA
GO_REF:0000107 		ACCEPT
Summary: Manual review: misfolded protein binding is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0101031 protein folding chaperone complex
IEA
GO_REF:0000107 		ACCEPT
Summary: Manual review: protein folding chaperone complex is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0051604 protein maturation
ISS
GO_REF:0000024 		ACCEPT
Summary: Manual review: protein maturation is consistent with known biology of Dnajb11.
Reason: Retained as supported or plausible for this gene and evidence context.
GO:0005102 signaling receptor binding
IPI
PMID:20335479
Protogenin defines a transition stage during embryonic neuro... 		KEEP AS NON CORE
Summary: Manual review: signaling receptor binding may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005615 extracellular space
IDA
PMID:20335479
Protogenin defines a transition stage during embryonic neuro... 		KEEP AS NON CORE
Summary: Manual review: extracellular space may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0050768 negative regulation of neurogenesis
ISO
PMID:20335479
Protogenin defines a transition stage during embryonic neuro... 		KEEP AS NON CORE
Summary: Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0050768 negative regulation of neurogenesis
IMP
PMID:20335479
Protogenin defines a transition stage during embryonic neuro... 		KEEP AS NON CORE
Summary: Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0050768 negative regulation of neurogenesis
IPI
PMID:20335479
Protogenin defines a transition stage during embryonic neuro... 		KEEP AS NON CORE
Summary: Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus
IDA
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolip... 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
IDA
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolip... 		KEEP AS NON CORE
Summary: Manual review: cytoplasm may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005634 nucleus
ISO
GO_REF:0000008 		KEEP AS NON CORE
Summary: Manual review: nucleus may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0005737 cytoplasm
ISO
GO_REF:0000008 		KEEP AS NON CORE
Summary: Manual review: cytoplasm may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0016556 mRNA modification
ISO
GO_REF:0000008 		KEEP AS NON CORE
Summary: Manual review: mRNA modification may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
GO:0051082 unfolded protein binding
IDA
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolip... 		MODIFY
Summary: Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.
Reason: Modified to align with current curation guidance and improve term specificity.
Proposed replacements: protein folding chaperone
GO:0005515 protein binding
IPI
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolip... 		MARK AS OVER ANNOTATED
Summary: Manual review: protein binding is too generic or over-extended for Dnajb11.
Reason: Marked over-annotated because more specific terms capture the biology more accurately.
GO:0016556 mRNA modification
IDA
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolip... 		KEEP AS NON CORE
Summary: Manual review: mRNA modification may be context-dependent or peripheral for Dnajb11.
Reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000008
Gene Ontology annotation by the MGI curatorial staff, curated orthology
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
PMID:11584023
A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.
PMID:20335479
Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.
PMID:21217698
Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.

📄 View Raw YAML

 
id: Q99KV1
gene_symbol: Dnajb11
product_type: PROTEIN
status: DRAFT
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Dnajb11'
existing_annotations:
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0051604
    label: protein maturation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: protein maturation is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051787
    label: misfolded protein binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'Manual review: misfolded protein binding is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'Manual review: endoplasmic reticulum lumen is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0006457
    label: protein folding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: protein folding is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21217698
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for Dnajb11.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0032781
    label: positive regulation of ATP-dependent activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'Manual review: positive regulation of ATP-dependent activity is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034663
    label: endoplasmic reticulum chaperone complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051604
    label: protein maturation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'Manual review: protein maturation is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051787
    label: misfolded protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'Manual review: misfolded protein binding is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0101031
    label: protein folding chaperone complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'Manual review: protein folding chaperone complex is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'Manual review: endoplasmic reticulum is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0034663
    label: endoplasmic reticulum chaperone complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'Manual review: endoplasmic reticulum chaperone complex is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051604
    label: protein maturation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'Manual review: protein maturation is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051787
    label: misfolded protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'Manual review: misfolded protein binding is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0101031
    label: protein folding chaperone complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'Manual review: protein folding chaperone complex is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0051604
    label: protein maturation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'Manual review: protein maturation is consistent with known biology of Dnajb11.'
    action: ACCEPT
    reason: Retained as supported or plausible for this gene and evidence context.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IPI
  original_reference_id: PMID:20335479
  review:
    summary: 'Manual review: signaling receptor binding may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005615
    label: extracellular space
  evidence_type: IDA
  original_reference_id: PMID:20335479
  review:
    summary: 'Manual review: extracellular space may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0050768
    label: negative regulation of neurogenesis
  evidence_type: ISO
  original_reference_id: PMID:20335479
  review:
    summary: 'Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0050768
    label: negative regulation of neurogenesis
  evidence_type: IMP
  original_reference_id: PMID:20335479
  review:
    summary: 'Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0050768
    label: negative regulation of neurogenesis
  evidence_type: IPI
  original_reference_id: PMID:20335479
  review:
    summary: 'Manual review: negative regulation of neurogenesis may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11584023
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:11584023
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: 'Manual review: nucleus may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: 'Manual review: cytoplasm may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0016556
    label: mRNA modification
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: 'Manual review: mRNA modification may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
- term:
    id: GO:0051082
    label: unfolded protein binding
  evidence_type: IDA
  original_reference_id: PMID:11584023
  review:
    summary: 'Manual review: unfolded protein binding is better represented by a more specific replacement term for Dnajb11.'
    action: MODIFY
    reason: Modified to align with current curation guidance and improve term specificity.
    proposed_replacement_terms:
    - id: GO:0044183
      label: protein folding chaperone
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11584023
  review:
    summary: 'Manual review: protein binding is too generic or over-extended for Dnajb11.'
    action: MARK_AS_OVER_ANNOTATED
    reason: Marked over-annotated because more specific terms capture the biology more accurately.
- term:
    id: GO:0016556
    label: mRNA modification
  evidence_type: IDA
  original_reference_id: PMID:11584023
  review:
    summary: 'Manual review: mRNA modification may be context-dependent or peripheral for Dnajb11.'
    action: KEEP_AS_NON_CORE
    reason: Kept as non-core to preserve potentially valid context-specific annotation without elevating it to core function.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000008
  title: Gene Ontology annotation by the MGI curatorial staff, curated orthology
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
  findings: []
- id: PMID:11584023
  title: A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing.
  findings: []
- id: PMID:20335479
  title: Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.
  findings: []
- id: PMID:21217698
  title: Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions.
  findings: []