Dopamine D1 receptor (Drd1, D1A) is a class A seven-transmembrane dopamine receptor. Its core molecular role is dopamine binding and G protein-coupled receptor signaling, predominantly through Gs/Golf-mediated stimulation of adenylyl cyclase and cAMP production at neuronal plasma and synaptic membranes. Reported D1-D2 receptor heteromers and ciliary localization add specialized signaling and trafficking contexts. Much of what is known about mouse Drd1 comes from knockout, drug-response and neuronal circuit studies, which report downstream physiological and behavioural consequences rather than the receptor's direct signalling activity.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004930 G protein-coupled receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons. |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: positive regulation of MAPK cascade is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway | IBA GO_REF:0000033 | MODIFY | Summary: The source evidence concerns D1-like dopamine receptor activation of adenylyl cyclase, but the adrenergic receptor pathway term is the wrong biological specificity for Drd1. Reason: Drd1 is a dopamine receptor, not an adrenergic receptor. The dopamine-specific adenylyl cyclase pathway term captures the same signaling mechanism without cross-transmitter overreach. Current PAINT places an IRD (NOT) for this term at PTN002798212 (2026-04-23), the vertebrate DRD1 clade, so this IBA is no longer propagated by PAINT and remains only in the cached GOA file. The IRD agrees with this verdict. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: WRONG ORTHOLOG OR PARALOG Sources checked: PANTHER:PTN001205212 SUPPORTS SOURCE BUT NOT TARGET Node in PTHR24248, whose PANTHER family name is "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR". The target is in that same family but in a different subfamily - UniProt assigns mouse Drd1 to PTHR24248:SF139 "D(1A) DOPAMINE RECEPTOR" - and every seed of this node is a beta-adrenergic receptor. The Gs/adenylyl-cyclase mechanism transfers across the subfamilies; the ligand qualifier carried by GO:0071880 does not. MGI:MGI:87938 · mouse Adrb2 (adrenergic receptor, beta 2) SUPPORTS SOURCE BUT NOT TARGET A genuine beta-adrenergic receptor, for which the adrenergic-qualified pathway term is correct; it is the transmitter qualifier that does not survive transfer to a dopamine receptor. MGI:MGI:87939 · mouse Adrb3 (adrenergic receptor, beta 3) SUPPORTS SOURCE BUT NOT TARGET Same beta-adrenergic subfamily as Adrb2; correct at the source, wrong ligand for the target. RGD:2061 · rat Adrb3 (adrenoceptor beta 3) SUPPORTS SOURCE BUT NOT TARGET Rat ortholog of the Adrb3 seed; adds phylogenetic depth to the beta-adrenergic clade, not to Drd1. UniProtKB:P07550 · human ADRB2 (Beta-2 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed; supports the adrenergic-qualified term at its own subfamily only. UniProtKB:P08588 · human ADRB1 (Beta-1 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed; supports the adrenergic-qualified term at its own subfamily only. UniProtKB:P13945 · human ADRB3 (Beta-3 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed. Note that GO:0007191 is not a child of GO:0071880 - both are children of GO:0007189 (adenylate cyclase-activating GPCR signaling pathway) - so the proposed replacement is a same-level re-scope onto the correct transmitter, not a narrowing of a parent. Proposed replacements: adenylate cyclase-activating dopamine receptor signaling pathway |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IBA GO_REF:0000033 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. file:mouse/Drd1/Drd1-deep-research-falcon.md Falcon synthesis supports Drd1 as a D1-like class A GPCR that couples dopamine binding to Gs/Golf-mediated adenylyl cyclase and cAMP/PKA signaling. |
| GO:0001975 response to amphetamine | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0004930 G protein-coupled receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0004952 dopamine neurotransmitter receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: endoplasmic reticulum membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0007165 signal transduction | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: signal transduction is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0007186 G protein-coupled receptor signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0008306 associative learning | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0016020 membrane | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0030425 dendrite | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0042220 response to cocaine | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042311 vasodilation | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: vasodilation is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0043197 dendritic spine | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0046960 sensitization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0060170 ciliary membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0060292 long-term synaptic depression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0120025 plasma membrane bounded cell projection | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: plasma membrane bounded cell projection is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | ISO GO_REF:0000119 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | ISO GO_REF:0000119 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | ISO GO_REF:0000119 | ACCEPT | Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0032795 heterotrimeric G-protein binding | ISO GO_REF:0000119 | ACCEPT | Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0035240 dopamine binding | ISO GO_REF:0000119 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0051281 positive regulation of release of sequestered calcium ion into cytosol | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060170 ciliary membrane | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0071870 cellular response to catecholamine stimulus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0097648 G protein-coupled receptor complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0097730 non-motile cilium | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:1990763 arrestin family protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IEA GO_REF:0000120 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | IEA GO_REF:0000107 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005929 cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | IEA GO_REF:0000107 | ACCEPT | Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0032795 heterotrimeric G-protein binding | IEA GO_REF:0000107 | ACCEPT | Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0035240 dopamine binding | IEA GO_REF:0000107 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0051281 positive regulation of release of sequestered calcium ion into cytosol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0071870 cellular response to catecholamine stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0097648 G protein-coupled receptor complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0097730 non-motile cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:1990763 arrestin family protein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0097731 9+0 non-motile cilium | IDA PMID:26053317 Identification of G Protein-Coupled Receptors (GPCRs) in Pri... | KEEP AS NON CORE | Summary: 9+0 non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0001934 positive regulation of protein phosphorylation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006469 negative regulation of protein kinase activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of protein kinase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | ISO GO_REF:0000096 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | ISO GO_REF:0000096 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0004930 G protein-coupled receptor activity | ISO GO_REF:0000096 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: signaling receptor binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005886 plasma membrane | ISO GO_REF:0000096 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0005901 caveola | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: caveola is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0006886 intracellular protein transport | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: intracellular protein transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | ISO GO_REF:0000096 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007625 grooming behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008306 associative learning | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0009986 cell surface | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cell surface is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0019229 regulation of vasoconstriction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of vasoconstriction is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0019722 calcium-mediated signaling | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: calcium-mediated signaling is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0019903 protein phosphatase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: protein phosphatase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0030336 negative regulation of cell migration | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0030424 axon | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0030425 dendrite | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0031701 angiotensin receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: angiotensin receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0031750 D3 dopamine receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: D3 dopamine receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0035106 operant conditioning | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035176 social behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: social behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035240 dopamine binding | ISO GO_REF:0000096 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0042321 negative regulation of circadian sleep/wake cycle, sleep | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of circadian sleep/wake cycle, sleep is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042734 presynaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0042755 eating behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: eating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0043025 neuronal cell body | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neuronal cell body is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043197 dendritic spine | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043198 dendritic shaft | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic shaft is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043269 regulation of monoatomic ion transport | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of monoatomic ion transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0043679 axon terminus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon terminus is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044326 dendritic spine neck | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine neck is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044327 dendritic spine head | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine head is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044877 protein-containing complex binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: protein-containing complex binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0045211 postsynaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0045838 positive regulation of membrane potential | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of membrane potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0048148 behavioral response to cocaine | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0050805 negative regulation of synaptic transmission | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0051117 ATPase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ATPase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0098978 glutamatergic synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0099170 postsynaptic modulation of chemical synaptic transmission | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1900038 negative regulation of cellular response to hypoxia | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cellular response to hypoxia is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1900273 positive regulation of long-term synaptic potentiation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of long-term synaptic potentiation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1901363 heterocyclic compound binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: heterocyclic compound binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:2000253 positive regulation of feeding behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042734 presynaptic membrane | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0045211 postsynaptic membrane | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | IDA PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | EXP PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098982 GABA-ergic synapse | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: GABA-ergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0099010 modification of postsynaptic structure | IDA PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099010 modification of postsynaptic structure | EXP PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | IDA PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | EXP PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007626 locomotory behavior | IGI PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:11923452 Alpha1b-adrenergic receptors control locomotor and rewarding... | UNDECIDED | Summary: PMID:11923452 is an alpha1b-adrenergic receptor knockout study and uses D1 agonist response to assess compensation, not to directly test Drd1 adenylyl cyclase signaling. Reason: The term matches canonical Drd1 pathway biology, but this specific PMID is indirect and non-Drd1-centric, so the annotation should not be accepted from this evidence. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IGI PMID:12223546 Impaired D2 dopamine receptor function in mice lacking type ... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:12665504 Motor dysfunction in type 5 adenylyl cyclase-null mice. | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco... | ACCEPT | Summary: Core D1 receptor cAMP pathway; the curator made paired IGI annotations (this term and GO:0060158) from the full text of PMID:17194762, which is abstract-only in the cache. Reason: The abstract contrasts the D1-D2 heteromer with activation of Gs/olf-coupled D1 receptors, so the paper assays the adenylate cyclase arm as well as the Gq/11 arm. Re-terming an experimental annotation to duplicate its companion from an abstract reading would overrule the curator without a refutation; the term is core Drd1 biology and is accepted on many other rows. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IDA PMID:15016423 Enhancement of dopamine-induced signaling responses in the f... | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco... | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0005929 cilium | ISO PMID:28154160 Tubby family proteins are adapters for ciliary trafficking o... | KEEP AS NON CORE | Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005515 protein binding | IPI PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0043197 dendritic spine | IDA PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in... | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0005515 protein binding | IPI PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0001932 regulation of protein phosphorylation | IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006468 protein phosphorylation | IDA PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | MARK AS OVER ANNOTATED | Summary: D1 receptor signaling increases histone H3 phosphorylation downstream, but Drd1 itself is the GPCR that initiates the cascade rather than a kinase, phosphorylation scaffold, or phosphorylation cofactor. Reason: PMID:18496528 traces this response through D1 receptor activation, cAMP-dependent protein phosphatase-2A activation, DARPP-32 dephosphorylation, protein phosphatase-1 inhibition, and downstream histone H3 phosphorylation. The GOA row is already qualified as acts_upstream_of_or_within, and the regulation-of-phosphorylation row captures this indirect regulatory effect more accurately than asserting that Drd1 itself participates in the phosphorylation step. Supporting Evidence: PMID:18496528 accumulation is mediated through a signalling cascade involving dopamine D1 |
| GO:0006606 protein import into nucleus | EXP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0005515 protein binding | IPI PMID:27460146 VPS35 regulates cell surface recycling and signaling of dopa... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005515 protein binding | IPI PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005783 endoplasmic reticulum | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | KEEP AS NON CORE | Summary: endoplasmic reticulum is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005886 plasma membrane | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons. |
| GO:0012505 endomembrane system | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | KEEP AS NON CORE | Summary: endomembrane system is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007626 locomotory behavior | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042711 maternal behavior | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042711 maternal behavior | IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | KEEP AS NON CORE | Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0046959 habituation | IMP PMID:11985822 Phenotypic resolution of spontaneous and D1-like agonist-ind... | KEEP AS NON CORE | Summary: habituation is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0001975 response to amphetamine | IGI PMID:21368124 Balanced NMDA receptor activity in dopamine D1 receptor (D1R... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0016020 membrane | IDA PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0016020 membrane | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0016020 membrane | IDA PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0009410 response to xenobiotic stimulus | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0098708 D-glucose import across plasma membrane | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: D-glucose import across plasma membrane is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001659 temperature homeostasis | IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of... | KEEP AS NON CORE | Summary: temperature homeostasis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001661 conditioned taste aversion | IMP PMID:15932618 Mice lacking dopamine D1 receptors express normal lithium ch... | KEEP AS NON CORE | Summary: conditioned taste aversion is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001662 behavioral fear response | IMP PMID:11172752 Prolonged fear responses in mice lacking dopamine D1 recepto... | KEEP AS NON CORE | Summary: behavioral fear response is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001963 synaptic transmission, dopaminergic | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: synaptic transmission, dopaminergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001975 response to amphetamine | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0004952 dopamine neurotransmitter receptor activity | IDA PMID:18671743 Decrease of D2 receptor binding but increase in D2-stimulate... | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005515 protein binding | IPI PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005634 nucleus | IDA PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | MARK AS OVER ANNOTATED | Summary: nucleus is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0006606 protein import into nucleus | IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006936 muscle contraction | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: muscle contraction is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007186 G protein-coupled receptor signaling pathway | IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr... | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IMP PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007612 learning | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007613 memory | IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ... | KEEP AS NON CORE | Summary: memory is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007625 grooming behavior | IMP PMID:9749770 Action sequencing is impaired in D1A-deficient mutant mice. | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:8001143 Elimination of cocaine-induced hyperactivity and dopamine-me... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008306 associative learning | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0008542 visual learning | IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0014002 astrocyte development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: astrocyte development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0015872 dopamine transport | IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr... | KEEP AS NON CORE | Summary: dopamine transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0019228 neuronal action potential | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: neuronal action potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0021542 dentate gyrus development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: dentate gyrus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021756 striatum development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: striatum development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021766 hippocampus development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: hippocampus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035106 operant conditioning | IMP PMID:12603275 Attenuation of sucrose reinforcement in dopamine D1 receptor... | KEEP AS NON CORE | Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042220 response to cocaine | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:12354293 The dopamine D1 receptor is a critical mediator for cocaine-... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:18045908 Lack of self-administration of cocaine in dopamine D1 recept... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0046960 sensitization | IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ... | KEEP AS NON CORE | Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0048148 behavioral response to cocaine | IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-... | KEEP AS NON CORE | Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:9427321 Dopamine D1-deficient mutant mice do not express the late ph... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060292 long-term synaptic depression | IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti... | KEEP AS NON CORE | Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0051968 positive regulation of synaptic transmission, glutamatergic | IMP PMID:8795639 Modulatory actions of dopamine on NMDA receptor-mediated res... | KEEP AS NON CORE | Summary: positive regulation of synaptic transmission, glutamatergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:11069937 Dopamine D2 long receptor-deficient mice display alterations... | UNDECIDED | Summary: PMID:11069937 is a D2L receptor-deficient mouse study and does not directly test Drd1 Gs-coupled receptor activity. Reason: The term matches Drd1 core molecular function, but this specific evidence is indirect and D2-centric, so the annotation should not be accepted from this PMID without direct Drd1 support. |
| GO:0007626 locomotory behavior | IGI PMID:11150348 Prepulse inhibition deficits and perseverative motor pattern... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IGI PMID:11089973 Distinct functions of the two isoforms of dopamine D2 recept... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0042053 regulation of dopamine metabolic process | IMP PMID:11438590 The role of dopamine receptors in regulating the size of axo... | KEEP AS NON CORE | Summary: regulation of dopamine metabolic process is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007626 locomotory behavior | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007631 feeding behavior | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0030432 peristalsis | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: peristalsis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021853 cerebral cortex GABAergic interneuron migration | IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration... | KEEP AS NON CORE | Summary: cerebral cortex GABAergic interneuron migration is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0030335 positive regulation of cell migration | IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration... | KEEP AS NON CORE | Summary: positive regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | ISO GO_REF:0000008 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007625 grooming behavior | IMP PMID:9988094 The expression of neuropeptide-induced excessive grooming be... | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | UNDECIDED | Summary: PMID:12097513 examines D2/D3 mutant responses to D1 agonist challenge and working-memory rescue, but the cached abstract does not directly demonstrate Drd1 Gs-coupled receptor activity. Reason: Direct Drd1 molecular-function support would require full-text confirmation; the available abstract supports indirect D1-mediated physiological context rather than direct Gs coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:7566118 Parkinsonian-like locomotor impairment in mice lacking dopam... | UNDECIDED | Summary: PMID:7566118 is a D2 receptor knockout study and does not provide direct cached support for Drd1 Gs-coupled molecular activity. Reason: The accessible abstract supports dopaminergic-system physiology centered on D2 receptor deficiency, not direct Drd1 receptor activity; full-text evidence would be needed. |
| GO:0001975 response to amphetamine | IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007628 adult walking behavior | IGI PMID:12652349 Essential conservation of D1 mutant phenotype at the level o... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007628 adult walking behavior | IMP PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007628 adult walking behavior | IGI PMID:9354330 Dopamine D3 receptor mutant mice exhibit increased behaviora... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:16962565 Low affinity binding of the classical D1 antagonist SCH23390... | UNDECIDED | Summary: PMID:16962565 analyzes SCH23390 binding states and D2/A2A receptor involvement; the cached abstract does not directly establish Drd1 Gs-coupled receptor activity. Reason: The abstract distinguishes binding components including sites independent of D1 expression, so direct Drd1 molecular-function support requires full-text confirmation. |
| GO:0004952 dopamine neurotransmitter receptor activity | ISO GO_REF:0000008 | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0007617 mating behavior | IDA PMID:9829800 Dopamine-stimulated sexual behavior is testosterone dependen... | KEEP AS NON CORE | Summary: mating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0004930 G protein-coupled receptor activity | IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase... | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0007186 G protein-coupled receptor signaling pathway | IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase... | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:12930822 Parkin-deficient mice exhibit nigrostriatal deficits but not... | UNDECIDED | Summary: PMID:12930822 reports parkin-deficient mouse nigrostriatal phenotypes and dopamine regulation; the cached abstract does not directly support Drd1 Gs-coupled molecular activity. Reason: The available evidence is indirect dopaminergic-system context; full-text confirmation would be needed before accepting this as a Drd1 molecular-function annotation. |
| GO:0019226 transmission of nerve impulse | IMP PMID:12867509 Receptor subtypes involved in the presynaptic and postsynapt... | KEEP AS NON CORE | Summary: transmission of nerve impulse is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007190 activation of adenylate cyclase activity | IDA PMID:12488442 Loss of G protein gamma 7 alters behavior and reduces striat... | KEEP AS NON CORE | Summary: activation of adenylate cyclase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0009410 response to xenobiotic stimulus | IDA PMID:7549459 Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) recep... | KEEP AS NON CORE | Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:8294904 Lesions of mouse striatum induced by 6-hydroxydopamine diffe... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
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Download this section (compressed HTML)Q: Which Drd1 annotations from whole-animal knockout or drug-response studies should remain GO biological process annotations versus be treated only as mouse phenotype evidence?
Q: Should D1-D2 heteromer-specific PLC/calcium signaling be annotated to Drd1 generally, or only in contexts where heteromer formation is directly demonstrated?
Q: Which neuronal compartments have endogenous Drd1 protein evidence in mouse rather than overexpression or orthology-transfer evidence?
Experiment: Measure endogenous Drd1 localization and signaling at plasma membrane, dendritic spine, and ciliary compartments using tagged knock-in Drd1 mice.
Hypothesis: Some specialized ciliary and synaptic annotations reflect context-specific receptor pools rather than general Drd1 localization.
Type: Endogenous tagging with quantitative imaging and cAMP biosensors
Experiment: Separate Gs/Golf and D1-D2 heteromer signaling with receptor mutants or cell-type-specific rescue in striatal medium spiny neurons.
Hypothesis: Canonical Drd1 signaling is Gs/Golf-cAMP mediated, while PLC/calcium terms require heteromer-specific context.
Type: Cell-type-specific genetic rescue and second-messenger assays
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