Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0004930 G protein-coupled receptor activity	IBA GO_REF:0000033	ACCEPT	Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation.
GO:0005886 plasma membrane	IBA GO_REF:0000033	ACCEPT	Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons.
GO:0043410 positive regulation of MAPK cascade	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of MAPK cascade is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway	IBA GO_REF:0000033	MODIFY	Summary: The source evidence concerns D1-like dopamine receptor activation of adenylyl cyclase, but the adrenergic receptor pathway term is the wrong biological specificity for Drd1. Reason: Drd1 is a dopamine receptor, not an adrenergic receptor. The dopamine-specific adenylyl cyclase pathway term captures the same signaling mechanism without cross-transmitter overreach. Proposed replacements: adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212 G protein-coupled dopamine receptor signaling pathway	IBA GO_REF:0000033	ACCEPT	Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IBA GO_REF:0000033	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. file:mouse/Drd1/Drd1-deep-research-falcon.md Falcon synthesis supports Drd1 as a D1-like class A GPCR that couples dopamine binding to Gs/Golf-mediated adenylyl cyclase and cAMP/PKA signaling.
GO:0001975 response to amphetamine	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0004930 G protein-coupled receptor activity	IEA GO_REF:0000120	ACCEPT	Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation.
GO:0004952 dopamine neurotransmitter receptor activity	IEA GO_REF:0000120	ACCEPT	Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0005789 endoplasmic reticulum membrane	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: endoplasmic reticulum membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0005886 plasma membrane	IEA GO_REF:0000120	ACCEPT	Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane.
GO:0007165 signal transduction	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: signal transduction is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0007186 G protein-coupled receptor signaling pathway	IEA GO_REF:0000120	ACCEPT	Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA GO_REF:0000120	ACCEPT	Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0008306 associative learning	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0016020 membrane	IEA GO_REF:0000002	KEEP AS NON CORE	Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0030425 dendrite	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0042220 response to cocaine	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042311 vasodilation	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: vasodilation is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0043197 dendritic spine	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0046960 sensitization	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0060170 ciliary membrane	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0060292 long-term synaptic depression	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0120025 plasma membrane bounded cell projection	IEA GO_REF:0000117	MARK AS OVER ANNOTATED	Summary: plasma membrane bounded cell projection is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	ISO GO_REF:0000119	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001965 G-protein alpha-subunit binding	ISO GO_REF:0000119	ACCEPT	Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0005886 plasma membrane	ISO GO_REF:0000119	ACCEPT	Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane.
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO GO_REF:0000119	ACCEPT	Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO GO_REF:0000119	ACCEPT	Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	ISO GO_REF:0000119	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0032795 heterotrimeric G-protein binding	ISO GO_REF:0000119	ACCEPT	Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0035240 dopamine binding	ISO GO_REF:0000119	ACCEPT	Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0060170 ciliary membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0071870 cellular response to catecholamine stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0097648 G protein-coupled receptor complex	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0097730 non-motile cilium	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:1990763 arrestin family protein binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IEA GO_REF:0000120	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001965 G-protein alpha-subunit binding	IEA GO_REF:0000107	ACCEPT	Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0005929 cilium	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA GO_REF:0000107	ACCEPT	Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IEA GO_REF:0000107	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0032795 heterotrimeric G-protein binding	IEA GO_REF:0000107	ACCEPT	Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0035240 dopamine binding	IEA GO_REF:0000107	ACCEPT	Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0071870 cellular response to catecholamine stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0097648 G protein-coupled receptor complex	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0097730 non-motile cilium	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:1990763 arrestin family protein binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0097731 9+0 non-motile cilium	IDA PMID:26053317 Identification of G Protein-Coupled Receptors (GPCRs) in Pri...	KEEP AS NON CORE	Summary: 9+0 non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0001934 positive regulation of protein phosphorylation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0006469 negative regulation of protein kinase activity	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of protein kinase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	ISO GO_REF:0000096	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001965 G-protein alpha-subunit binding	ISO GO_REF:0000096	ACCEPT	Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0004930 G protein-coupled receptor activity	ISO GO_REF:0000096	ACCEPT	Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation.
GO:0005102 signaling receptor binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: signaling receptor binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0005886 plasma membrane	ISO GO_REF:0000096	ACCEPT	Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane.
GO:0005901 caveola	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: caveola is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0006886 intracellular protein transport	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: intracellular protein transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	ISO GO_REF:0000096	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0007625 grooming behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0008306 associative learning	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0009986 cell surface	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cell surface is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal.
GO:0019229 regulation of vasoconstriction	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: regulation of vasoconstriction is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal.
GO:0019722 calcium-mediated signaling	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: calcium-mediated signaling is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0019903 protein phosphatase binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: protein phosphatase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0030336 negative regulation of cell migration	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0030424 axon	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: axon is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0030425 dendrite	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0031701 angiotensin receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: angiotensin receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0031750 D3 dopamine receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: D3 dopamine receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0035106 operant conditioning	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0035176 social behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: social behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0035240 dopamine binding	ISO GO_REF:0000096	ACCEPT	Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of circadian sleep/wake cycle, sleep is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0042734 presynaptic membrane	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0042755 eating behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: eating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0043025 neuronal cell body	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: neuronal cell body is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0043197 dendritic spine	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0043198 dendritic shaft	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendritic shaft is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0043269 regulation of monoatomic ion transport	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: regulation of monoatomic ion transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0043679 axon terminus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: axon terminus is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0044326 dendritic spine neck	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendritic spine neck is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0044327 dendritic spine head	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendritic spine head is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0044877 protein-containing complex binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: protein-containing complex binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0045211 postsynaptic membrane	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0045838 positive regulation of membrane potential	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of membrane potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0048148 behavioral response to cocaine	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0050805 negative regulation of synaptic transmission	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0051117 ATPase binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: ATPase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function.
GO:0098978 glutamatergic synapse	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0099170 postsynaptic modulation of chemical synaptic transmission	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: postsynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:1900038 negative regulation of cellular response to hypoxia	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of cellular response to hypoxia is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:1900273 positive regulation of long-term synaptic potentiation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of long-term synaptic potentiation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:1901363 heterocyclic compound binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: heterocyclic compound binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:2000253 positive regulation of feeding behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0042734 presynaptic membrane	IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ...	KEEP AS NON CORE	Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0045211 postsynaptic membrane	IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ...	KEEP AS NON CORE	Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0098978 glutamatergic synapse	IDA PMID:25258080 A critical time window for dopamine actions on the structura...	KEEP AS NON CORE	Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0098978 glutamatergic synapse	EXP PMID:25258080 A critical time window for dopamine actions on the structura...	KEEP AS NON CORE	Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0098978 glutamatergic synapse	IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ...	KEEP AS NON CORE	Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0098982 GABA-ergic synapse	IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ...	KEEP AS NON CORE	Summary: GABA-ergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0099010 modification of postsynaptic structure	IDA PMID:25258080 A critical time window for dopamine actions on the structura...	KEEP AS NON CORE	Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0099010 modification of postsynaptic structure	EXP PMID:25258080 A critical time window for dopamine actions on the structura...	KEEP AS NON CORE	Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0099171 presynaptic modulation of chemical synaptic transmission	IDA PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop...	KEEP AS NON CORE	Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0099171 presynaptic modulation of chemical synaptic transmission	EXP PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop...	KEEP AS NON CORE	Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0007626 locomotory behavior	IGI PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0008542 visual learning	IMP PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in...	KEEP AS NON CORE	Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IDA PMID:11923452 Alpha1b-adrenergic receptors control locomotor and rewarding...	UNDECIDED	Summary: PMID:11923452 is an alpha1b-adrenergic receptor knockout study and uses D1 agonist response to assess compensation, not to directly test Drd1 adenylyl cyclase signaling. Reason: The term matches canonical Drd1 pathway biology, but this specific PMID is indirect and non-Drd1-centric, so the annotation should not be accepted from this evidence.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IGI PMID:12223546 Impaired D2 dopamine receptor function in mice lacking type ...	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IDA PMID:12665504 Motor dysfunction in type 5 adenylyl cyclase-null mice.	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco...	MODIFY	Summary: PMID:17194762 supports D1-D2 heteromer signaling through Gq/11 and intracellular calcium release, not adenylyl-cyclase activation. Reason: The original term has the correct dopamine receptor signaling context but the wrong second messenger specificity for this PMID; use the phospholipase C/calcium dopamine receptor pathway already represented by the companion annotation. Proposed replacements: phospholipase C-activating dopamine receptor signaling pathway
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway	IDA PMID:15016423 Enhancement of dopamine-induced signaling responses in the f...	KEEP AS NON CORE	Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway	IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco...	KEEP AS NON CORE	Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0005929 cilium	ISO PMID:28154160 Tubby family proteins are adapters for ciliary trafficking o...	KEEP AS NON CORE	Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0005515 protein binding	IPI PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in...	MARK AS OVER ANNOTATED	Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0043197 dendritic spine	IDA PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in...	KEEP AS NON CORE	Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IDA PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D...	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0005515 protein binding	IPI PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D...	MARK AS OVER ANNOTATED	Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0001932 regulation of protein phosphorylation	IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc...	KEEP AS NON CORE	Summary: regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0006468 protein phosphorylation	IDA PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc...	KEEP AS NON CORE	Summary: protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0006606 protein import into nucleus	EXP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc...	KEEP AS NON CORE	Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0005515 protein binding	IPI PMID:27460146 VPS35 regulates cell surface recycling and signaling of dopa...	MARK AS OVER ANNOTATED	Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0005515 protein binding	IPI PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d...	MARK AS OVER ANNOTATED	Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0005783 endoplasmic reticulum	IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d...	KEEP AS NON CORE	Summary: endoplasmic reticulum is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0005886 plasma membrane	IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d...	ACCEPT	Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons.
GO:0012505 endomembrane system	IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d...	KEEP AS NON CORE	Summary: endomembrane system is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0007626 locomotory behavior	IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0042711 maternal behavior	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0042711 maternal behavior	IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa...	KEEP AS NON CORE	Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0046959 habituation	IMP PMID:11985822 Phenotypic resolution of spontaneous and D1-like agonist-ind...	KEEP AS NON CORE	Summary: habituation is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal.
GO:0001975 response to amphetamine	IGI PMID:21368124 Balanced NMDA receptor activity in dopamine D1 receptor (D1R...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0016020 membrane	IDA PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa...	KEEP AS NON CORE	Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0016020 membrane	IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del...	KEEP AS NON CORE	Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0016020 membrane	IDA PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys...	KEEP AS NON CORE	Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity.
GO:0009410 response to xenobiotic stimulus	IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking...	KEEP AS NON CORE	Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0098708 D-glucose import across plasma membrane	IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking...	KEEP AS NON CORE	Summary: D-glucose import across plasma membrane is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001659 temperature homeostasis	IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of...	KEEP AS NON CORE	Summary: temperature homeostasis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001661 conditioned taste aversion	IMP PMID:15932618 Mice lacking dopamine D1 receptors express normal lithium ch...	KEEP AS NON CORE	Summary: conditioned taste aversion is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001662 behavioral fear response	IMP PMID:11172752 Prolonged fear responses in mice lacking dopamine D1 recepto...	KEEP AS NON CORE	Summary: behavioral fear response is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001963 synaptic transmission, dopaminergic	IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/...	KEEP AS NON CORE	Summary: synaptic transmission, dopaminergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0001975 response to amphetamine	IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0001975 response to amphetamine	IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0001975 response to amphetamine	IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0001975 response to amphetamine	IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0001975 response to amphetamine	IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0001975 response to amphetamine	IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0004952 dopamine neurotransmitter receptor activity	IDA PMID:18671743 Decrease of D2 receptor binding but increase in D2-stimulate...	ACCEPT	Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0005515 protein binding	IPI PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys...	MARK AS OVER ANNOTATED	Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0005634 nucleus	IDA PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias...	MARK AS OVER ANNOTATED	Summary: nucleus is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
GO:0006606 protein import into nucleus	IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc...	KEEP AS NON CORE	Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0006936 muscle contraction	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: muscle contraction is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007186 G protein-coupled receptor signaling pathway	IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr...	ACCEPT	Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IMP PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys...	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0007212 G protein-coupled dopamine receptor signaling pathway	IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/...	ACCEPT	Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007612 learning	IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc...	KEEP AS NON CORE	Summary: learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007613 memory	IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ...	KEEP AS NON CORE	Summary: memory is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007625 grooming behavior	IMP PMID:9749770 Action sequencing is impaired in D1A-deficient mutant mice.	KEEP AS NON CORE	Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:8001143 Elimination of cocaine-induced hyperactivity and dopamine-me...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007626 locomotory behavior	IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0008306 associative learning	IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor...	KEEP AS NON CORE	Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0008542 visual learning	IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ...	KEEP AS NON CORE	Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0008542 visual learning	IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc...	KEEP AS NON CORE	Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0008542 visual learning	IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor...	KEEP AS NON CORE	Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0014002 astrocyte development	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: astrocyte development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0015872 dopamine transport	IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr...	KEEP AS NON CORE	Summary: dopamine transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0019228 neuronal action potential	IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/...	KEEP AS NON CORE	Summary: neuronal action potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0021542 dentate gyrus development	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: dentate gyrus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0021756 striatum development	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: striatum development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0021766 hippocampus development	IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ...	KEEP AS NON CORE	Summary: hippocampus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0035106 operant conditioning	IMP PMID:12603275 Attenuation of sucrose reinforcement in dopamine D1 receptor...	KEEP AS NON CORE	Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0042220 response to cocaine	IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042220 response to cocaine	IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042220 response to cocaine	IMP PMID:12354293 The dopamine D1 receptor is a critical mediator for cocaine-...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042220 response to cocaine	IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042220 response to cocaine	IMP PMID:18045908 Lack of self-administration of cocaine in dopamine D1 recept...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0042220 response to cocaine	IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias...	KEEP AS NON CORE	Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0046960 sensitization	IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ...	KEEP AS NON CORE	Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0048148 behavioral response to cocaine	IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-...	KEEP AS NON CORE	Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0060291 long-term synaptic potentiation	IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti...	KEEP AS NON CORE	Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0060291 long-term synaptic potentiation	IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti...	KEEP AS NON CORE	Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0060291 long-term synaptic potentiation	IMP PMID:9427321 Dopamine D1-deficient mutant mice do not express the late ph...	KEEP AS NON CORE	Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0060292 long-term synaptic depression	IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti...	KEEP AS NON CORE	Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0051968 positive regulation of synaptic transmission, glutamatergic	IMP PMID:8795639 Modulatory actions of dopamine on NMDA receptor-mediated res...	KEEP AS NON CORE	Summary: positive regulation of synaptic transmission, glutamatergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:11069937 Dopamine D2 long receptor-deficient mice display alterations...	UNDECIDED	Summary: PMID:11069937 is a D2L receptor-deficient mouse study and does not directly test Drd1 Gs-coupled receptor activity. Reason: The term matches Drd1 core molecular function, but this specific evidence is indirect and D2-centric, so the annotation should not be accepted from this PMID without direct Drd1 support.
GO:0007626 locomotory behavior	IGI PMID:11150348 Prepulse inhibition deficits and perseverative motor pattern...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007212 G protein-coupled dopamine receptor signaling pathway	IGI PMID:11089973 Distinct functions of the two isoforms of dopamine D2 recept...	ACCEPT	Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0042053 regulation of dopamine metabolic process	IMP PMID:11438590 The role of dopamine receptors in regulating the size of axo...	KEEP AS NON CORE	Summary: regulation of dopamine metabolic process is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0007626 locomotory behavior	IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated...	KEEP AS NON CORE	Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007631 feeding behavior	IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated...	KEEP AS NON CORE	Summary: feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0030432 peristalsis	IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated...	KEEP AS NON CORE	Summary: peristalsis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0021853 cerebral cortex GABAergic interneuron migration	IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration...	KEEP AS NON CORE	Summary: cerebral cortex GABAergic interneuron migration is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0030335 positive regulation of cell migration	IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration...	KEEP AS NON CORE	Summary: positive regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway	ISO GO_REF:0000008	KEEP AS NON CORE	Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0007625 grooming behavior	IMP PMID:9988094 The expression of neuropeptide-induced excessive grooming be...	KEEP AS NON CORE	Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki...	UNDECIDED	Summary: PMID:12097513 examines D2/D3 mutant responses to D1 agonist challenge and working-memory rescue, but the cached abstract does not directly demonstrate Drd1 Gs-coupled receptor activity. Reason: Direct Drd1 molecular-function support would require full-text confirmation; the available abstract supports indirect D1-mediated physiological context rather than direct Gs coupling.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:7566118 Parkinsonian-like locomotor impairment in mice lacking dopam...	UNDECIDED	Summary: PMID:7566118 is a D2 receptor knockout study and does not provide direct cached support for Drd1 Gs-coupled molecular activity. Reason: The accessible abstract supports dopaminergic-system physiology centered on D2 receptor deficiency, not direct Drd1 receptor activity; full-text evidence would be needed.
GO:0001975 response to amphetamine	IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki...	KEEP AS NON CORE	Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function.
GO:0007212 G protein-coupled dopamine receptor signaling pathway	IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki...	ACCEPT	Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0007628 adult walking behavior	IGI PMID:12652349 Essential conservation of D1 mutant phenotype at the level o...	KEEP AS NON CORE	Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007628 adult walking behavior	IMP PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e...	KEEP AS NON CORE	Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0007628 adult walking behavior	IGI PMID:9354330 Dopamine D3 receptor mutant mice exhibit increased behaviora...	KEEP AS NON CORE	Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:16962565 Low affinity binding of the classical D1 antagonist SCH23390...	UNDECIDED	Summary: PMID:16962565 analyzes SCH23390 binding states and D2/A2A receptor involvement; the cached abstract does not directly establish Drd1 Gs-coupled receptor activity. Reason: The abstract distinguishes binding components including sites independent of D1 expression, so direct Drd1 molecular-function support requires full-text confirmation.
GO:0004952 dopamine neurotransmitter receptor activity	ISO GO_REF:0000008	ACCEPT	Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype.
GO:0007617 mating behavior	IDA PMID:9829800 Dopamine-stimulated sexual behavior is testosterone dependen...	KEEP AS NON CORE	Summary: mating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0004930 G protein-coupled receptor activity	IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase...	ACCEPT	Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation.
GO:0007186 G protein-coupled receptor signaling pathway	IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase...	ACCEPT	Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:12930822 Parkin-deficient mice exhibit nigrostriatal deficits but not...	UNDECIDED	Summary: PMID:12930822 reports parkin-deficient mouse nigrostriatal phenotypes and dopamine regulation; the cached abstract does not directly support Drd1 Gs-coupled molecular activity. Reason: The available evidence is indirect dopaminergic-system context; full-text confirmation would be needed before accepting this as a Drd1 molecular-function annotation.
GO:0019226 transmission of nerve impulse	IMP PMID:12867509 Receptor subtypes involved in the presynaptic and postsynapt...	KEEP AS NON CORE	Summary: transmission of nerve impulse is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0007190 activation of adenylate cyclase activity	IDA PMID:12488442 Loss of G protein gamma 7 alters behavior and reduces striat...	KEEP AS NON CORE	Summary: activation of adenylate cyclase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling.
GO:0009410 response to xenobiotic stimulus	IDA PMID:7549459 Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) recep...	KEEP AS NON CORE	Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:8294904 Lesions of mouse striatum induced by 6-hydroxydopamine diffe...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs	IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del...	ACCEPT	Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway	IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del...	ACCEPT	Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Core Functions

Binds dopamine as a D1-like class A GPCR and activates Gs/Golf-coupled signaling.

Molecular Function:

dopamine neurotransmitter receptor activity, coupled via Gs

Directly Involved In:

adenylate cyclase-activating dopamine receptor signaling pathway G protein-coupled dopamine receptor signaling pathway

Cellular Locations:

plasma membrane

Supporting Evidence:

UniProtKB:Q61616
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
file:mouse/Drd1/Drd1-deep-research-falcon.md
Falcon synthesis identifies D1 receptor signaling through Gs/Golf, adenylyl cyclase, cAMP, and PKA as the canonical Drd1 pathway.

Recognizes dopamine ligand through the conserved D1 receptor seven-transmembrane binding pocket.

Molecular Function:

dopamine binding

Directly Involved In:

G protein-coupled dopamine receptor signaling pathway

Cellular Locations:

plasma membrane

Supporting Evidence:

UniProtKB:Q61616
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
file:mouse/Drd1/Drd1-deep-research-falcon.md
Falcon synthesis supports dopamine sensing by the D1 receptor seven-transmembrane binding pocket as the initiating molecular function.

Couples activated receptor to heterotrimeric Gs/Golf proteins to drive adenylyl cyclase activation and cAMP signaling.

Molecular Function:

G-protein alpha-subunit binding

Directly Involved In:

adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway

Cellular Locations:

plasma membrane

Supporting Evidence:

UniProtKB:Q61616
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
file:mouse/Drd1/Drd1-deep-research-falcon.md
Falcon synthesis supports coupling of activated Drd1 to Gs/Golf proteins as the route to adenylyl cyclase activation and cAMP signaling.

References

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000008

Gene Ontology annotation by the MGI curatorial staff, curated orthology

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000096

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000119

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10222120

Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice.

PMID:10585522

Spatial learning deficit in dopamine D(1) receptor knockout mice.

PMID:10661513

Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.

PMID:10884517

Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors.

PMID:11069937

Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions.

PMID:11089973

Distinct functions of the two isoforms of dopamine D2 receptors.

PMID:11150348

Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists.

PMID:11172752

Prolonged fear responses in mice lacking dopamine D1 receptor.

PMID:11251190

Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors.

PMID:11404425

Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum.

PMID:11438590

The role of dopamine receptors in regulating the size of axonal arbors.

PMID:11823893

Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice.

PMID:11923452

Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates.

D1 agonist response was used to rule out basal dopaminergic compensation in alpha1b-adrenergic receptor knockout mice, not to directly test Drd1 adenylyl-cyclase signaling.

"Because catecholamine tissue levels, autoradiography of D1 and D2 dopaminergic receptors, and of dopamine reuptake sites and locomotor response to a D1 agonist showed that basal dopaminergic transmission was similar in knock-out and wild-type mice"

PMID:11985822

Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice.

PMID:12097513

Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits.

PMID:12223546

Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.

Type 5 adenylyl cyclase loss eliminates most striatal D1 agonist-stimulated adenylyl cyclase activity, supporting D1 receptor coupling to AC5/cAMP signaling.

"The genetic ablation of the AC5 gene eliminated >80% of forskolin-induced AC activity and 85-90% of AC activity stimulated by either D1 or A2A receptor agonists in striatum."
AC5 is presented as a striatal signaling integrator for D1, D2, and A2A receptors.

"Together, these results suggest that AC5 is the principal AC integrating signals from multiple receptors including D1, D2, and A2A in striatum"

PMID:12354293

The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression.

PMID:12488442

Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production.

PMID:12603275

Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice.

PMID:12652349

Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors.

PMID:12665504

Motor dysfunction in type 5 adenylyl cyclase-null mice.

D1 dopaminergic agonist-stimulated adenylyl cyclase activity is attenuated in AC5-null striatum, supporting Drd1/AC5/cAMP pathway coupling.

"D1 dopaminergic agonist-stimulated adenylyl cyclase activity was attenuated, and this was accompanied by a decrease in the expression of the D1 dopaminergic receptor and G(s)alpha."
D1 stimulation partially compensates through remnant adenylyl cyclase isoforms in AC5-null mice.

"Selective D1 or D2 dopaminergic stimulation improved some of these disorders in this mouse model, suggesting the partial compensation of each dopaminergic receptor signal through the stimulation of remnant adenylyl cyclase isoforms."

PMID:12867509

Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons.

PMID:12930822

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.

PMID:13679419

Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity.

PMID:14712229

G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.

PMID:14981263

Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors.

PMID:15016423

Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor.

PMID:15272078

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.

PMID:15684065

Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place.

PMID:15932618

Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned taste aversion for salt but not sucrose.

PMID:16014726

Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference.

PMID:16908842

Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.

PMID:16962565

Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors.

PMID:17194762

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.

D1-D2 receptor heteromers can couple to Gq/11 and intracellular calcium release, supporting PLC/calcium annotations as specialized non-core signaling contexts.

PMID:17360497

Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior.

PMID:17409246

Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex.

PMID:18045908

Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.

PMID:18486343

Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors.

PMID:18496528

A phosphatase cascade by which rewarding stimuli control nucleosomal response.

PMID:18671743

Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm.

PMID:21368124

Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization.

PMID:22586226

Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core.

PMID:23842570

Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.

PMID:24550737

Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons.

SLC35D3 interacts with D1R and affects ER exit and surface levels, supporting ER/endomembrane trafficking annotations as non-core receptor handling.

PMID:25258080

A critical time window for dopamine actions on the structural plasticity of dendritic spines.

PMID:25865831

Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus.

PMID:26053317

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.

PMID:27035941

Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures.

PMID:27460146

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.

VPS35 regulates DRD1 surface recycling and CREB/ERK signaling, supporting trafficking and downstream phosphorylation annotations as non-core.

PMID:28154160

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.

TULP3/TUB adapter work supports D1R ciliary trafficking as a specialized localization context.

PMID:7549459

Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in morphine tolerance and dependence in mice.

PMID:7566118

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors.

PMID:7809078

Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

PMID:7954836

Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.

PMID:8001143

Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice.

D1 receptor mutant mice lack cocaine-induced locomotor stimulation and show reduced dopamine-mediated nucleus accumbens neurophysiology, supporting downstream drug-response and locomotor annotations as non-core phenotypes.

PMID:8294904

Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors.

PMID:8738226

Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors.

PMID:8795639

Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.

PMID:9016340

D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice.

PMID:9261820

Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse.

PMID:9354330

Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors.

PMID:9387887

D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene.

PMID:9427321

Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation.

D1-deficient mice show loss of late-phase hippocampal LTP, supporting synaptic plasticity annotations as circuit-level consequences of receptor signaling.

PMID:9692749

Behavioural assessment of mice lacking D1A dopamine receptors.

PMID:9749770

Action sequencing is impaired in D1A-deficient mutant mice.

PMID:9829800

Dopamine-stimulated sexual behavior is testosterone dependent in mice.

PMID:9988094

The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2 receptor-deficient mice.

UniProtKB:Q61616

UniProt record for mouse Drd1 (Q61616)

Drd1 is a dopamine receptor mediated by G proteins that activate adenylyl cyclase.
UniProt places Drd1 at cell membrane, ER membrane, ciliary membrane, dendrite, and dendritic spine contexts.

file:mouse/Drd1/Drd1-deep-research-falcon.md

Falcon deep research summary for mouse Drd1

Falcon synthesis supports Drd1 as a D1-like class A GPCR whose core output is Gs/Golf-mediated adenylyl cyclase activation and cAMP/PKA signaling.
Falcon synthesis treats ciliary, endosomal, dendritic-spine, and receptor-complex signaling as important but context-specific Drd1 biology.

Suggested Experiments

Experiment: Measure endogenous Drd1 localization and signaling at plasma membrane, dendritic spine, and ciliary compartments using tagged knock-in Drd1 mice.

Hypothesis: Some specialized ciliary and synaptic annotations reflect context-specific receptor pools rather than general Drd1 localization.

Type: Endogenous tagging with quantitative imaging and cAMP biosensors

Experiment: Separate Gs/Golf and D1-D2 heteromer signaling with receptor mutants or cell-type-specific rescue in striatal medium spiny neurons.

Hypothesis: Canonical Drd1 signaling is Gs/Golf-cAMP mediated, while PLC/calcium terms require heteromer-specific context.

Type: Cell-type-specific genetic rescue and second-messenger assays

📚 Additional Documentation

Deep Research Falcon

(Drd1-deep-research-falcon.md)

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D1 receptor;'
gene_info: Name=Drd1; Synonyms=Drd1a, Gpcr15;
organism_full: Mus musculus (Mouse).
protein_family: Belongs to the G-protein coupled receptor 1 family.
protein_domains: Dopamine_D1_rcpt. (IPR001413); Dopamine_rcpt. (IPR000929); GPCR_Rhodpsn.
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Question

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.

Target Gene/Protein Identity (from UniProt):

UniProt Accession: Q61616
Protein Description: RecName: Full=D(1A) dopamine receptor; AltName: Full=Dopamine D1 receptor;
Gene Information: Name=Drd1; Synonyms=Drd1a, Gpcr15;
Organism (full): Mus musculus (Mouse).
Protein Family: Belongs to the G-protein coupled receptor 1 family.
Key Domains: Dopamine_D1_rcpt. (IPR001413); Dopamine_rcpt. (IPR000929); GPCR_Rhodpsn. (IPR000276); GPCR_Rhodpsn_7TM. (IPR017452); 7tm_1 (PF00001)

MANDATORY VERIFICATION STEPS:

Check if the gene symbol "Drd1" matches the protein description above
Verify the organism is correct: Mus musculus (Mouse).
Check if protein family/domains align with what you find in literature
If you find literature for a DIFFERENT gene with the same or similar symbol, STOP

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE. Instead:
- State clearly: "The gene symbol 'Drd1' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information

Research Target:

Please provide a comprehensive research report on the gene Drd1 (gene ID: Drd1, UniProt: Q61616) in mouse.

The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.

We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.

We are interested in where in or outside the cell the gene product carries out its function.

We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.

Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.

Output

Question: You are an expert researcher providing comprehensive, well-cited information.

Provide detailed information focusing on:
1. Key concepts and definitions with current understanding
2. Recent developments and latest research (prioritize 2023-2024 sources)
3. Current applications and real-world implementations
4. Expert opinions and analysis from authoritative sources
5. Relevant statistics and data from recent studies

Format as a comprehensive research report with proper citations. Include URLs and publication dates where available.
Always prioritize recent, authoritative sources and provide specific citations for all major claims.

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.

Target Gene/Protein Identity (from UniProt):

UniProt Accession: Q61616
Protein Description: RecName: Full=D(1A) dopamine receptor; AltName: Full=Dopamine D1 receptor;
Gene Information: Name=Drd1; Synonyms=Drd1a, Gpcr15;
Organism (full): Mus musculus (Mouse).
Protein Family: Belongs to the G-protein coupled receptor 1 family.
Key Domains: Dopamine_D1_rcpt. (IPR001413); Dopamine_rcpt. (IPR000929); GPCR_Rhodpsn. (IPR000276); GPCR_Rhodpsn_7TM. (IPR017452); 7tm_1 (PF00001)

MANDATORY VERIFICATION STEPS:

Check if the gene symbol "Drd1" matches the protein description above
Verify the organism is correct: Mus musculus (Mouse).
Check if protein family/domains align with what you find in literature
If you find literature for a DIFFERENT gene with the same or similar symbol, STOP

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Please provide a comprehensive research report on the gene Drd1 (gene ID: Drd1, UniProt: Q61616) in mouse.

The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

We are interested in where in or outside the cell the gene product carries out its function.

We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.

Research Report: Mouse Drd1 (Dopamine D1 receptor; UniProt Q61616)

0) Target verification (mandatory)

The UniProt-provided identity (Q61616) corresponds to Mus musculus dopamine D1 receptor (DRD1; Drd1/Drd1a), a D1-like dopamine receptor in the rhodopsin-like (class A) GPCR superfamily. The recent literature retrieved here consistently describes “dopamine D1 receptors (D1R)” as excitatory GPCRs that activate adenylyl cyclase and raise intracellular cAMP, with prominent striatal expression and canonical coupling to the cAMP/PKA axis, matching the UniProt description and domain family expectations. (kawahata2024dopamined1–d5receptors pages 1-2, albraidy2024synapseassociatedprotein102 pages 50-53)

1) Key concepts & definitions (current understanding)

1.1 What DRD1 is

DRD1 (D1 receptor; D1R) is a dopamine-responsive GPCR that primarily drives excitatory neuromodulatory signaling by stimulating adenylyl cyclase → cAMP production (often framed as D1-like receptor biology) and is central to neural functions including movement, motivation/reward, and cognition. (kawahata2024dopamined1–d5receptors pages 1-2, kawahata2024dopamined1–d5receptors pages 25-27)

1.2 Canonical signaling definition: “D1-like” pathway

In the D1-like framework, D1 receptors are defined by their ability to activate adenylyl cyclase and elevate cAMP, thereby engaging protein kinase A (PKA)-dependent responses (a central pathway for dopaminergic modulation). (kawahata2024dopamined1–d5receptors pages 1-2)

1.3 Modern view: signaling is spatiotemporally compartmentalized

Recent reviews and primary studies emphasize that GPCR outputs are not only determined by ligand and receptor, but also by subcellular location (plasma membrane vs endosomes vs Golgi-adjacent pools vs primary cilia), which can bias downstream cAMP/PKA responses. For D1R specifically, evidence supports endosomal cAMP signaling and subcellular mechanisms that route PKA effects toward specific outputs (e.g., nuclear vs cytoplasmic). (albraidy2024synapseassociatedprotein102 pages 123-128, ripoll2024spatialorganizationof media 54915a4d)

2) Molecular function: what DRD1 “does” biochemically

2.1 Primary molecular function

DRD1 is a dopamine receptor whose core molecular function is ligand-triggered signal transduction, converting dopamine binding into intracellular second messenger signaling (cAMP/PKA) that modulates neuronal excitability, synaptic function, and gene expression. (kawahata2024dopamined1–d5receptors pages 1-2, silva2024leucinerichrepeatkinase pages 1-2)

2.2 Downstream effectors and pathway integration

A current mechanistic emphasis is that D1R signaling integrates with other neuronal signaling hubs, including:
- PKA axis (canonical), which is a major downstream branch of D1R activation in striatal D1-MSNs (direct-pathway spiny projection neurons). (silva2024leucinerichrepeatkinase pages 1-2)
- ERK/MAPK axis, which can be engaged via β-arrestin–dependent scaffolding and can synergize with Gαs signaling when phosphorylated D1R binds both Gαs and β-arrestin 2. (albraidy2024synapseassociatedprotein102 pages 123-128)

3) Cellular & subcellular localization

3.1 Brain-region and cell-type localization

A consistent contemporary view is that D1 receptors are abundant in striatal medium spiny neurons, classically associated with direct-pathway striatal projection neurons (often referred to as D1-MSNs/dSPNs), and are also found across multiple brain nuclei involved in motor, cognitive, and affective regulation. (kawahata2024dopamined1–d5receptors pages 25-27, kawahata2024dopamined1–d5receptors pages 1-2)

3.2 Synaptic and postsynaptic-density localization; glutamatergic integration

At excitatory synapses, D1R is reported to be colocalized with the postsynaptic density (PSD) and can be functionally linked to glutamate receptors:
- D1R and NMDAR can colocalize at the PSD; NMDAR activation increases D1R surface expression and cAMP production, reduces agonist-induced D1R endocytosis, and increases D1R-positive spines (spine trapping). (albraidy2024synapseassociatedprotein102 pages 134-137)
- D1R activation can conversely suppress NMDAR-mediated currents by reducing NMDAR synaptic trafficking. (albraidy2024synapseassociatedprotein102 pages 134-137)
These observations support a functional annotation in which D1R serves as a neuromodulatory receptor that couples dopamine tone to glutamatergic synaptic plasticity and spine signaling. (albraidy2024synapseassociatedprotein102 pages 134-137)

3.3 Intracellular pools: endosomes, Golgi-adjacent signaling, and primary cilia

Endosomes / juxtanuclear signaling: A 2024 Nature Communications study in striatal neurons reports that adenylyl cyclase isoforms show distinct spatial distributions and that AC9 is uniquely concentrated in endosomes; further, AC9-containing endosomes accumulate activated dopamine receptors and form a spatial network near juxtanuclear PKA stores bound to Golgi membranes, enabling selective routing of PKA activity to the nucleus relative to the cytoplasm. (ripoll2024spatialorganizationof media 54915a4d)

Primary cilia: A 2024 cilia-focused work using in vivo D1-APEX2 proximity labeling reports that neuronal primary cilia can be enriched for signaling effectors including AC3 and β-arrestin, and discusses that perturbing cilia on D1 neurons can reduce D1 signaling and alter physiology (e.g., locomotion and body weight), indicating that ciliary localization can be functionally consequential for D1-linked pathways. (stubbs2024localizationofg pages 126-133)

4) Recent developments and latest research (prioritized 2023–2024)

4.1 Negative regulation of D1R→PKA signaling by LRRK2 (2024)

A 2024 Neuropsychopharmacology study reports that LRRK2 acts as a negative modulator of D1 receptors in striatum, with evidence that global Lrrk2 deletion enhanced PKA signaling downstream of D1R, while gain-of-function Lrrk2 mutations reduced PKA activity, supporting a model in which LRRK2 constrains D1R→PKA signaling in direct-pathway MSNs. This connects a Parkinson’s-disease-linked kinase to the core D1 functional axis. Publication date: Sep 2024. URL: https://doi.org/10.1038/s41386-023-01731-z (silva2024leucinerichrepeatkinase pages 1-2)

4.2 Spatial organization of cAMP generation and nuclear PKA bias via AC9 endosomes (2024)

A 2024 Nature Communications paper provides a mechanistic framework for how D1-related cAMP signaling can be spatially routed: endosomal AC9 localization and proximity to juxtanuclear PKA stores supports selective nuclear PKA elevation. Publication date: Sep 2024. URL: https://doi.org/10.1038/s41467-024-52575-0 (ripoll2024spatialorganizationof media 54915a4d)

4.3 In vivo receptor-proximal proteomics to map D1 microenvironment (2024)

A 2024 study described D1-APEX2 proximity labeling in vivo (D1AP2/AP2 mice) to identify proteins proximal to D1R across compartments (including endosomes and Golgi-associated regions), with statistical thresholds (log2 fold-change cutoffs and adjusted p-values) and a reported dataset size. This represents a methodological development for functional annotation that moves beyond bulk expression to context-specific receptor microenvironments. (stubbs2024localizationofg pages 126-133)

4.4 Evolving understanding of noncanonical signaling and receptor complexes (2024)

A 2024 synthesis focused on D1-class receptor regulation highlights mechanistic models in which D1R phosphorylation and β-arrestin engagement can enable ERK1/2 activation independent of cAMP, including evidence that phosphorylated D1R can bind Gαs and β-arrestin 2 concurrently to synergistically activate ERK1/2. It also summarizes evidence for D1R involvement in receptor complexes (e.g., with NMDAR and mGluR5) that can alter trafficking, signaling bias, and Ca2+ coupling. (albraidy2024synapseassociatedprotein102 pages 123-128, albraidy2024synapseassociatedprotein102 pages 134-137)

5) Current applications and real-world implementations

5.1 Cell-type specific genetics (Drd1-Cre) and pathway dissection

Much of modern D1R biology in mouse is implemented through the D1R neuron genetic-access strategy (e.g., Drd1/Drd1a promoter-driven Cre or reporters), enabling cell-type specific perturbation and circuit mapping. For example, the LRRK2 study used genetic strategies focusing on D1R-expressing neurons and D1R-targeted readouts (e.g., c-Fos after D1 agonist administration) to connect molecular regulation to behavior. (silva2024leucinerichrepeatkinase pages 1-2)

5.2 Quantitative live imaging of the canonical D1→PKA axis

A 2024 Scientific Reports paper introduces a Cre-dependent reporter mouse for quantitative real-time imaging of PKA activity dynamics (FLIM-AKAR expressed from ROSA26). This enables direct measurement of PKA dynamics downstream of GPCR signaling pathways in genetically targeted neurons, including D1R-SPNs. Publication date: Feb 2024. URL: https://doi.org/10.1038/s41598-024-53313-8 (tilden2024acredependentreporter pages 8-9)

5.3 Chemogenetic tuning of dopamine sensors (2024)

A 2024 Nature Communications paper presents a chemogenetic approach for dopamine imaging in which a D1 positive allosteric modulator (DETQ) is used to boost GPCR-based dopamine sensor sensitivity. This approach leverages a key implementation detail: DETQ is substantially more potent at human DRD1 than mouse Drd1, enabling selective potentiation of sensors engineered from human DRD1 when used in mouse experiments. Publication date: Jul 2024. URL: https://doi.org/10.1038/s41467-024-49442-3 (labouesse2024achemogeneticapproach pages 1-2)

5.4 PET imaging of D1 receptors as a translational bridge

A 2024 D1–D5 receptor review highlights PET imaging using [11C]SCH23390 as a widely used D1-family imaging approach and frames such imaging as a key translational tool linking receptor biology to aging and disease contexts. Publication date: Apr 2024. URL: https://doi.org/10.3390/receptors3020009 (kawahata2024dopamined1–d5receptors pages 17-19)

6) Quantitative statistics and data points (recent studies)

Key recent quantitative values directly relevant to D1/Drd1 research workflows include:

1) Species selectivity for chemogenetic dopamine imaging (DETQ):
- DETQ binding allosteric potency/selectivity reported as Kb(human DRD1) = 11.4 nM and Kb(mouse DRD1) = 312 nM (>30-fold difference), supporting selective potentiation of human DRD1-based sensors in mouse. (Jul 2024; https://doi.org/10.1038/s41467-024-49442-3) (labouesse2024achemogeneticapproach pages 1-2)

2) Sensor sensitivity improvements under DETQ potentiation:
- A sensor mutant (dLight1.3bL143I) was reported with EC50(DA) = 142 nM vs 244 nM (as described in the retrieved evidence) and an affinity/sensitivity enhancement factor α = 10.8; the in vivo potentiation window reported was ~31 minutes without behavioral effects. (Jul 2024; https://doi.org/10.1038/s41467-024-49442-3) (labouesse2024achemogeneticapproach pages 1-2)

3) In vivo D1R proximity proteomics dataset and thresholds:
- D1-APEX2/cilia work reports a proximity dataset of ~276 proteins, using log2FC ≥ 1 or ≤ −1 and adjusted p < 0.05 as criteria for differential representation. (stubbs2024localizationofg pages 126-133)

4) PKA reporter mouse implementation detail:
- The Cre-dependent PKA reporter line is indicated to be available as JAX 039003, facilitating standardized deployment of quantitative PKA imaging in D1R-expressing neurons. (Feb 2024; https://doi.org/10.1038/s41598-024-53313-8) (tilden2024acredependentreporter pages 8-9)

7) Expert synthesis (authoritative analysis from reviews and high-impact studies)

Across recent reviews and primary work, an expert-consensus functional annotation for mouse Drd1 can be summarized as:

1) Core function: DRD1 is a dopamine-activated neuromodulatory receptor whose primary output is the cAMP/PKA axis, prominently in striatal D1-MSNs; this axis regulates excitability and plasticity and is linked to movement and reward-related functions. (kawahata2024dopamined1–d5receptors pages 1-2, silva2024leucinerichrepeatkinase pages 1-2)

2) Mechanistic nuance: D1R signaling is not purely “one pathway.” D1R participates in β-arrestin-enabled ERK signaling and in receptor complexes (notably with NMDAR and mGluR5) that reshape trafficking, spine localization, and potentially Ca2+ signaling, providing mechanistic diversity in how dopamine modulates neurons. (albraidy2024synapseassociatedprotein102 pages 134-137, albraidy2024synapseassociatedprotein102 pages 123-128)

3) Location-biased physiology: Compartmentalization (endosomal and potentially ciliary pools) is increasingly recognized as a core determinant of functional output, with 2024 work detailing a mechanism for how endosome-associated adenylyl cyclase (AC9) and receptor localization can bias nuclear PKA signaling. (ripoll2024spatialorganizationof media 54915a4d, stubbs2024localizationofg pages 126-133)

8) Evidence figure supporting compartmentalized D1-linked cAMP/PKA signaling

The following schematic summarizes the 2024 evidence that endosomal localization (AC9-containing endosomes accumulating activated dopamine receptors) can enable proximity to juxtanuclear PKA stores and selectively route downstream PKA activity.

(ripoll2024spatialorganizationof media 54915a4d)

9) Summary table (functional annotation at a glance)

A compact, evidence-backed summary is provided below.

Category	Key points	Representative recent paper(s)	Quantitative numbers
Identity / definition	Drd1 in mouse corresponds to the dopamine D1 receptor (D1R), a D1-like excitatory class A/rhodopsin-like GPCR that stimulates adenylyl cyclase and cAMP signaling; strongly linked to movement, motivation, reward, and cognition, with especially prominent striatal expression (kawahata2024dopamined1–d5receptors pages 1-2, albraidy2024synapseassociatedprotein102 pages 50-53)	Kawahata et al., 2024 review (kawahata2024dopamined1–d5receptors pages 1-2); Albraidy, 2024 (albraidy2024synapseassociatedprotein102 pages 50-53)	No direct quantitative identity metric reported in the cited contexts
Molecular function	Primary molecular role is dopamine sensing at the cell surface and in intracellular compartments, converting extracellular dopamine signals into intracellular second-messenger responses that alter excitability and transcription; D1R also modulates glutamatergic signaling at synapses and can participate in receptor complexes with NMDA, mGluR5, D3, and D2 partners (albraidy2024synapseassociatedprotein102 pages 134-137, albraidy2024synapseassociatedprotein102 pages 123-128)	Albraidy, 2024 (albraidy2024synapseassociatedprotein102 pages 134-137, albraidy2024synapseassociatedprotein102 pages 123-128)	No single catalytic reaction; receptor function is ligand-triggered signal transduction
Canonical signaling	Core pathway is Gαs/Gαolf → adenylyl cyclase → cAMP → PKA, with downstream engagement of DARPP-32 and ERK/MAPK modules in striatal neurons; recent in vivo work supports D1R→PKA signaling in D1-MSNs and shows LRRK2 constrains this pathway (kawahata2024dopamined1–d5receptors pages 1-2, stubbs2024localizationofg pages 154-155, silva2024leucinerichrepeatkinase pages 1-2)	Kawahata et al., 2024 (kawahata2024dopamined1–d5receptors pages 1-2); Stubbs, 2024 (stubbs2024localizationofg pages 154-155); da Silva et al., 2024 (silva2024leucinerichrepeatkinase pages 1-2)	SKF81297 used at 2 mg/kg in vivo in D1R-cell assays; slice recordings from 8–12 week mice and 230 μm slices in LRRK2 study (silva2024leucinerichrepeatkinase pages 1-2)
Noncanonical / compartmentalized signaling	D1R signaling is location-biased: evidence supports endosomal cAMP signaling, sustained Gαs/β-arrestin megaplex-like signaling, and spatial control of downstream PKA outputs. In striatal neurons, AC9 is uniquely concentrated in endosomes, and AC9-containing endosomes accumulate activated dopamine receptors near juxtanuclear PKA stores on Golgi membranes, favoring nuclear PKA signaling. D1 also shows altered signaling when localized to primary cilia, where cilia are enriched in AC3 and β-arrestin (albraidy2024synapseassociatedprotein102 pages 123-128, stubbs2024localizationofg pages 126-133, ripoll2024spatialorganizationof media 54915a4d)	Ripoll et al., 2024 (ripoll2024spatialorganizationof media 54915a4d); Stubbs, 2024 (stubbs2024localizationofg pages 126-133); Albraidy, 2024 (albraidy2024synapseassociatedprotein102 pages 123-128)	D1-APEX2/cilia proteomics used log2FC ≤ -1 or ≥ 1 with adjusted p < 0.05; ~276 proteins detected in proximity dataset (stubbs2024localizationofg pages 126-133)
Scaffolds / trafficking regulation	D1R is regulated by β-arrestins, receptor phosphorylation, endocytosis, and PDZ-domain scaffolds such as PSD-95/SAP102. β-arrestin contributes to ERK1/2 activation and internalization; phosphorylated D1R can bind Gαs and βArr2 simultaneously. At synapses, NMDAR activation increases D1R surface expression and cAMP output, reduces agonist-induced D1R endocytosis, and traps D1R in spines; D1R is highly mobile and enriched in spine heads (albraidy2024synapseassociatedprotein102 pages 123-128, albraidy2024synapseassociatedprotein102 pages 134-137)	Albraidy, 2024 (albraidy2024synapseassociatedprotein102 pages 134-137, albraidy2024synapseassociatedprotein102 pages 123-128)	No direct kinetic constants provided in cited contexts
Expression / localization	D1R is highly expressed in striatal direct-pathway spiny projection neurons (dSPNs/D1-MSNs) and also detected in nucleus accumbens, cortex, substantia nigra, and other nuclei. Localization is both postsynaptic and presynaptic, with important subcellular pools at plasma membrane, dendritic spines, endosomes, Golgi-adjacent zones, and primary cilia (kawahata2024dopamined1–d5receptors pages 25-27, albraidy2024synapseassociatedprotein102 pages 50-53, stubbs2024localizationofg pages 126-133)	Kawahata et al., 2024 (kawahata2024dopamined1–d5receptors pages 25-27); Albraidy, 2024 (albraidy2024synapseassociatedprotein102 pages 50-53); Stubbs, 2024 (stubbs2024localizationofg pages 126-133)	Ciliary perturbation in D1 neurons caused decreased D1 signaling, increased body weight, and decreased locomotor activity (qualitative summary) (stubbs2024localizationofg pages 126-133)
Recent 2023–2024 developments	New work emphasizes: (1) striatal circuit revisions showing dSPN collateral signaling beyond canonical models; (2) cell-type specific disease mechanisms in alcohol use, compulsivity, dyskinesia, ADHD-like phenotypes, feeding, anxiety, and opioid withdrawal; (3) stronger focus on subcellular/cAMP nanodomains and receptor-proximal proteomics for D1R biology (silva2024leucinerichrepeatkinase pages 1-2, ripoll2024spatialorganizationof media 54915a4d, kawahata2024dopamined1–d5receptors pages 21-23)	da Silva et al., 2024 (silva2024leucinerichrepeatkinase pages 1-2); Ripoll et al., 2024 (ripoll2024spatialorganizationof media 54915a4d); Kawahata et al., 2024 (kawahata2024dopamined1–d5receptors pages 21-23)	Recent cilia/proximity study defined analytical cutoffs above; multiple studies used cell-specific mouse manipulations rather than reporting receptor abundance numbers
Applications / tools	D1R biology is implemented in Drd1-Cre / Drd1a-driven mouse lines, tdTomato reporter crosses, chemogenetic and optogenetic manipulations, PKA activity imaging, GPCR-based dopamine sensors, and PET mapping with [11C]SCH23390. The FL-AK mouse enables Cre-dependent live PKA imaging in D1R-SPNs; D1-APEX2 enables in vivo receptor-proximal proteomics; GPCR-based dopamine sensors can be chemogenetically potentiated with a D1 PAM (tilden2024acredependentreporter pages 8-9, labouesse2024achemogeneticapproach pages 1-2, kawahata2024dopamined1–d5receptors pages 17-19)	Tilden et al., 2024 (tilden2024acredependentreporter pages 8-9); Labouesse et al., 2024 (labouesse2024achemogeneticapproach pages 1-2); Kawahata et al., 2024 (kawahata2024dopamined1–d5receptors pages 17-19)	FL-AK reporter available as JAX 039003; D1 agonist SKF81297 1 μM used in reporter validation; PET studies use [11C]SCH23390 (tilden2024acredependentreporter pages 8-9, kawahata2024dopamined1–d5receptors pages 17-19)
Quantitative stats	Quantitative recent values include: DETQ Kb human DRD1 = 11.4 nM; mouse DRD1 = 312 nM; sensor mutant dLight1.3bL143I EC50 = 142 nM versus 244 nM after WT DETQ potentiation context; potentiation window ~31 min without behavioral effects; D1-APEX2 proteomics: ~276 proteins, log2FC cutoff ±1, adjusted p < 0.05; human imaging study: D1-PET/MRI dataset n = 177 with [11C]SCH23390 (labouesse2024achemogeneticapproach pages 1-2, stubbs2024localizationofg pages 126-133, kawahata2024dopamined1–d5receptors pages 17-19)	Labouesse et al., 2024 (labouesse2024achemogeneticapproach pages 1-2); Stubbs, 2024 (stubbs2024localizationofg pages 126-133); Pedersen et al., 2024 via search context summarized in available evidence set (kawahata2024dopamined1–d5receptors pages 17-19)	Kb 11.4 nM vs 312 nM; EC50 142 nM vs 244 nM; α = 10.8; 31-min window; ~276 proteins; log2FC ±1; adj. p < 0.05; n = 177 (labouesse2024achemogeneticapproach pages 1-2, stubbs2024localizationofg pages 126-133, kawahata2024dopamined1–d5receptors pages 17-19)

Table: This table summarizes the core functional annotation of mouse Drd1/DRD1, integrating molecular function, signaling, localization, recent 2023–2024 findings, and practical research tools. It is designed as a compact reference for evidence-backed claims and key quantitative values.

References

(kawahata2024dopamined1–d5receptors pages 1-2): Ichiro Kawahata, David I. Finkelstein, and Kohji Fukunaga. Dopamine d1–d5 receptors in brain nuclei: implications for health and disease. Receptors, 3:155-181, Apr 2024. URL: https://doi.org/10.3390/receptors3020009, doi:10.3390/receptors3020009. This article has 52 citations.
(albraidy2024synapseassociatedprotein102 pages 50-53): Bassam Albraidy. Synapse-associated protein 102 and postsynaptic density 95 regulate dopamine d1-class receptors in subtype-specific manner. Unknown, Feb 2024. URL: https://doi.org/10.20381/ruor-30113, doi:10.20381/ruor-30113. This article has 0 citations.
(kawahata2024dopamined1–d5receptors pages 25-27): Ichiro Kawahata, David I. Finkelstein, and Kohji Fukunaga. Dopamine d1–d5 receptors in brain nuclei: implications for health and disease. Receptors, 3:155-181, Apr 2024. URL: https://doi.org/10.3390/receptors3020009, doi:10.3390/receptors3020009. This article has 52 citations.
(albraidy2024synapseassociatedprotein102 pages 123-128): Bassam Albraidy. Synapse-associated protein 102 and postsynaptic density 95 regulate dopamine d1-class receptors in subtype-specific manner. Unknown, Feb 2024. URL: https://doi.org/10.20381/ruor-30113, doi:10.20381/ruor-30113. This article has 0 citations.
(ripoll2024spatialorganizationof media 54915a4d): Léa Ripoll, Yong Li, Carmen W. Dessauer, and Mark von Zastrow. Spatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons. Nature Communications, Sep 2024. URL: https://doi.org/10.1038/s41467-024-52575-0, doi:10.1038/s41467-024-52575-0. This article has 18 citations and is from a highest quality peer-reviewed journal.
(silva2024leucinerichrepeatkinase pages 1-2): Daniel da Silva, Aya Matsui, Erin M. Murray, Adamantios Mamais, Michael E. Authement, Jung Hoon Shin, Marlisa Shaw, Dorit Ron, Mark R. Cookson, and Veronica A. Alvarez. Leucine-rich repeat kinase 2 limits dopamine d1 receptor signaling in striatum and biases against heavy persistent alcohol drinking. Neuropsychopharmacology, 49:824-836, Sep 2024. URL: https://doi.org/10.1038/s41386-023-01731-z, doi:10.1038/s41386-023-01731-z. This article has 11 citations and is from a highest quality peer-reviewed journal.
(albraidy2024synapseassociatedprotein102 pages 134-137): Bassam Albraidy. Synapse-associated protein 102 and postsynaptic density 95 regulate dopamine d1-class receptors in subtype-specific manner. Unknown, Feb 2024. URL: https://doi.org/10.20381/ruor-30113, doi:10.20381/ruor-30113. This article has 0 citations.
(stubbs2024localizationofg pages 126-133): TD Stubbs. Localization of g protein coupled receptors to primary cilia and its impact on neuronal function. Unknown journal, 2024.
(tilden2024acredependentreporter pages 8-9): Elizabeth I. Tilden, Aditi Maduskar, Anna Oldenborg, Bernardo L. Sabatini, and Yao Chen. A cre-dependent reporter mouse for quantitative real-time imaging of protein kinase a activity dynamics. Scientific Reports, Feb 2024. URL: https://doi.org/10.1038/s41598-024-53313-8, doi:10.1038/s41598-024-53313-8. This article has 8 citations and is from a peer-reviewed journal.
(labouesse2024achemogeneticapproach pages 1-2): Marie A. Labouesse, Maria Wilhelm, Zacharoula Kagiampaki, Andrew G. Yee, Raphaelle Denis, Masaya Harada, Andrea Gresch, Alina-Măriuca Marinescu, Kanako Otomo, Sebastiano Curreli, Laia Serratosa Capdevila, Xuehan Zhou, Reto B. Cola, Luca Ravotto, Chaim Glück, Stanislav Cherepanov, Bruno Weber, Xin Zhou, Jason Katner, Kjell A. Svensson, Tommaso Fellin, Louis-Eric Trudeau, Christopher P. Ford, Yaroslav Sych, and Tommaso Patriarchi. A chemogenetic approach for dopamine imaging with tunable sensitivity. Nature Communications, Jul 2024. URL: https://doi.org/10.1038/s41467-024-49442-3, doi:10.1038/s41467-024-49442-3. This article has 14 citations and is from a highest quality peer-reviewed journal.
(kawahata2024dopamined1–d5receptors pages 17-19): Ichiro Kawahata, David I. Finkelstein, and Kohji Fukunaga. Dopamine d1–d5 receptors in brain nuclei: implications for health and disease. Receptors, 3:155-181, Apr 2024. URL: https://doi.org/10.3390/receptors3020009, doi:10.3390/receptors3020009. This article has 52 citations.
(stubbs2024localizationofg pages 154-155): TD Stubbs. Localization of g protein coupled receptors to primary cilia and its impact on neuronal function. Unknown journal, 2024.
(kawahata2024dopamined1–d5receptors pages 21-23): Ichiro Kawahata, David I. Finkelstein, and Kohji Fukunaga. Dopamine d1–d5 receptors in brain nuclei: implications for health and disease. Receptors, 3:155-181, Apr 2024. URL: https://doi.org/10.3390/receptors3020009, doi:10.3390/receptors3020009. This article has 52 citations.

Citations

silva2024leucinerichrepeatkinase pages 1-2
stubbs2024localizationofg pages 126-133
tilden2024acredependentreporter pages 8-9
labouesse2024achemogeneticapproach pages 1-2
stubbs2024localizationofg pages 154-155
11C
https://doi.org/10.1038/s41386-023-01731-z
https://doi.org/10.1038/s41467-024-52575-0
https://doi.org/10.1038/s41598-024-53313-8
https://doi.org/10.1038/s41467-024-49442-3
https://doi.org/10.3390/receptors3020009
https://doi.org/10.3390/receptors3020009,
https://doi.org/10.20381/ruor-30113,
https://doi.org/10.1038/s41467-024-52575-0,
https://doi.org/10.1038/s41386-023-01731-z,
https://doi.org/10.1038/s41598-024-53313-8,
https://doi.org/10.1038/s41467-024-49442-3,

Notes

(Drd1-notes.md)

Drd1 review notes

Drd1 encodes the mouse D(1A) dopamine receptor, a class A GPCR. UniProt summarizes the core function as "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase" [UniProtKB:Q61616].

The strongest core GO terms are dopamine receptor activity coupled via Gs/Golf, dopamine binding, G-protein alpha-subunit binding, and adenylate cyclase-activating dopamine receptor signaling. The UniProt record also lists plasma membrane, ER membrane, ciliary membrane, dendrite, and dendritic spine localizations, so these cellular component terms are plausible, but most are contextual rather than the core activity [UniProtKB:Q61616].

Knockout and pharmacology literature strongly supports downstream phenotypes, but these should not be confused with molecular function. D1A knockout mice lack striatal D1A receptor binding and show altered striatal function, including reduced rearing behavior PMID:7809078. D1 receptor mutant mice also fail to show normal cocaine-induced locomotor stimulation and dopamine-mediated nucleus accumbens electrophysiological responses PMID:8001143.

Synaptic plasticity annotations are biologically relevant but downstream. D1-deficient mice show defective late-phase hippocampal LTP PMID:9427321, and striatal studies distinguish D1 and D5 receptor roles in motor activity and plasticity PMID:13679419.

PLC/calcium annotations should be treated as specialized non-core signaling. The D1-D2 dopamine receptor heteromer paper reports a complex that activates Gq/11 and intracellular calcium release PMID:17194762. This supports retaining phospholipase C-activating dopamine receptor signaling as non-core, not as the general Drd1 pathway.

Trafficking and ciliary annotations are supported but contextual. SLC35D3 interacts with D1R and affects ER exit and plasma membrane delivery PMID:24550737. VPS35 regulates DRD1 recycling and downstream CREB/ERK phosphorylation PMID:27460146. TULP3/TUB work supports ciliary trafficking of D1R as one specialized localization context PMID:28154160.

Generic protein binding, signaling receptor binding, heterocyclic compound binding, signal transduction, vasodilation, and computational behavioral predictions are weak as direct Drd1 functional annotations. They were marked over-annotated where the more specific receptor, ligand-binding, G-protein coupling, or pathway terms already represent the underlying biology.

📄 View Raw YAML

id: Q61616
gene_symbol: Drd1
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'Dopamine D1 receptor (Drd1, D1A) is a class A seven-transmembrane dopamine receptor. Its
  core molecular role is dopamine binding and G protein-coupled receptor signaling, predominantly through
  Gs/Golf-mediated stimulation of adenylyl cyclase and cAMP production at neuronal plasma and synaptic
  membranes. Reported D1-D2 receptor heteromers and ciliary localization add specialized signaling and
  trafficking contexts. Many mouse GO annotations reflect downstream phenotypes from knockout, drug-response,
  or neuronal circuit studies and are therefore retained as non-core rather than as the primary function
  of the gene product.'
existing_annotations:
- term:
    id: GO:0004930
    label: G protein-coupled receptor activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: G protein-coupled receptor activity is a correct parent-level molecular function for
      Drd1, though the dopamine- and Gs-coupled terms are more informative.
    action: ACCEPT
    reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific
      representation.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine
      receptor signaling.
    action: ACCEPT
    reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the
      plasma membrane.
    supported_by:
    - reference_id: PMID:24550737
      supporting_text: Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons.
- term:
    id: GO:0043410
    label: positive regulation of MAPK cascade
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: positive regulation of MAPK cascade is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0071880
    label: adenylate cyclase-activating adrenergic receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: The source evidence concerns D1-like dopamine receptor activation of adenylyl cyclase,
      but the adrenergic receptor pathway term is the wrong biological specificity for Drd1.
    action: MODIFY
    reason: Drd1 is a dopamine receptor, not an adrenergic receptor. The dopamine-specific adenylyl
      cyclase pathway term captures the same signaling mechanism without cross-transmitter
      overreach.
    proposed_replacement_terms:
    - id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
- term:
    id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1
      receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
    - reference_id: file:mouse/Drd1/Drd1-deep-research-falcon.md
      supporting_text: Falcon synthesis supports Drd1 as a D1-like class A GPCR
        that couples dopamine binding to Gs/Golf-mediated adenylyl cyclase and
        cAMP/PKA signaling.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0004930
    label: G protein-coupled receptor activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: G protein-coupled receptor activity is a correct parent-level molecular function for
      Drd1, though the dopamine- and Gs-coupled terms are more informative.
    action: ACCEPT
    reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific
      representation.
- term:
    id: GO:0004952
    label: dopamine neurotransmitter receptor activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function:
      dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate
      cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0005789
    label: endoplasmic reticulum membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: endoplasmic reticulum membrane is supported as a localization or trafficking context
      for D1 receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine
      receptor signaling.
    action: ACCEPT
    reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the
      plasma membrane.
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000043
  review:
    summary: signal transduction is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0007186
    label: G protein-coupled receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor
      signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007189
    label: adenylate cyclase-activating G protein-coupled receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents
      the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf
      activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0008306
    label: associative learning
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: associative learning is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: membrane is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042311
    label: vasodilation
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: vasodilation is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0043197
    label: dendritic spine
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: dendritic spine is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0046960
    label: sensitization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0060170
    label: ciliary membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0060292
    label: long-term synaptic depression
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: long-term synaptic depression is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0120025
    label: plasma membrane bounded cell projection
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: plasma membrane bounded cell projection is not wrong as a broad or downstream
      association, but it is not an informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001965
    label: G-protein alpha-subunit binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition
      and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine
      receptor signaling.
    action: ACCEPT
    reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the
      plasma membrane.
- term:
    id: GO:0007187
    label: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second
      messenger
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second
      messenger represents the canonical D1 receptor signaling pathway downstream of dopamine
      binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007189
    label: adenylate cyclase-activating G protein-coupled receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents
      the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf
      activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0032795
    label: heterotrimeric G-protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition
      and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0035240
    label: dopamine binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling
      to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0051281
    label: positive regulation of release of sequestered calcium ion into cytosol
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream
      or specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0060158
    label: phospholipase C-activating dopamine receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0060170
    label: ciliary membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0071870
    label: cellular response to catecholamine stimulus
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to catecholamine stimulus is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0097648
    label: G protein-coupled receptor complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: G protein-coupled receptor complex is supported as a localization or trafficking
      context for D1 receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0097730
    label: non-motile cilium
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: non-motile cilium is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:1990763
    label: arrestin family protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: arrestin family protein binding captures a reported receptor complex or regulatory
      interaction rather than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001965
    label: G-protein alpha-subunit binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition
      and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0005929
    label: cilium
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is
      secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0007187
    label: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second
      messenger
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second
      messenger represents the canonical D1 receptor signaling pathway downstream of dopamine
      binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0032795
    label: heterotrimeric G-protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition
      and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0035240
    label: dopamine binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling
      to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0051281
    label: positive regulation of release of sequestered calcium ion into cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream
      or specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0060158
    label: phospholipase C-activating dopamine receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0071870
    label: cellular response to catecholamine stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to catecholamine stimulus is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0097648
    label: G protein-coupled receptor complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: G protein-coupled receptor complex is supported as a localization or trafficking
      context for D1 receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0097730
    label: non-motile cilium
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: non-motile cilium is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:1990763
    label: arrestin family protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: arrestin family protein binding captures a reported receptor complex or regulatory
      interaction rather than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0097731
    label: 9+0 non-motile cilium
  evidence_type: IDA
  original_reference_id: PMID:26053317
  review:
    summary: 9+0 non-motile cilium is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0001934
    label: positive regulation of protein phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of protein phosphorylation is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0006469
    label: negative regulation of protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of protein kinase activity is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001965
    label: G-protein alpha-subunit binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition
      and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0004930
    label: G protein-coupled receptor activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: G protein-coupled receptor activity is a correct parent-level molecular function for
      Drd1, though the dopamine- and Gs-coupled terms are more informative.
    action: ACCEPT
    reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific
      representation.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: signaling receptor binding is not wrong as a broad or downstream association, but it is
      not an informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine
      receptor signaling.
    action: ACCEPT
    reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the
      plasma membrane.
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: caveola is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0006886
    label: intracellular protein transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: intracellular protein transport is a downstream or specialized signaling consequence of
      D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0007625
    label: grooming behavior
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0008306
    label: associative learning
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: associative learning is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0009986
    label: cell surface
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cell surface is retained as a non-core annotation pending more granular review of the
      original evidence.
    action: KEEP_AS_NON_CORE
    reason: The term is not the primary receptor activity, but the existing evidence does not
      justify removal.
- term:
    id: GO:0019229
    label: regulation of vasoconstriction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: regulation of vasoconstriction is retained as a non-core annotation pending more
      granular review of the original evidence.
    action: KEEP_AS_NON_CORE
    reason: The term is not the primary receptor activity, but the existing evidence does not
      justify removal.
- term:
    id: GO:0019722
    label: calcium-mediated signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: calcium-mediated signaling is a downstream or specialized signaling consequence of D1
      receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0019903
    label: protein phosphatase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein phosphatase binding captures a reported receptor complex or regulatory
      interaction rather than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0030336
    label: negative regulation of cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of cell migration is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0030424
    label: axon
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: axon is supported as a localization or trafficking context for D1 receptor, but it is
      secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0031701
    label: angiotensin receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: angiotensin receptor binding captures a reported receptor complex or regulatory
      interaction rather than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0031750
    label: D3 dopamine receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: D3 dopamine receptor binding captures a reported receptor complex or regulatory
      interaction rather than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0035106
    label: operant conditioning
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0035176
    label: social behavior
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: social behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0035240
    label: dopamine binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling
      to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0042321
    label: negative regulation of circadian sleep/wake cycle, sleep
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of circadian sleep/wake cycle, sleep is a mouse phenotype or
      circuit-level outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0042734
    label: presynaptic membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: presynaptic membrane is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0042755
    label: eating behavior
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: eating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0043025
    label: neuronal cell body
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: neuronal cell body is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0043197
    label: dendritic spine
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendritic spine is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0043198
    label: dendritic shaft
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendritic shaft is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0043269
    label: regulation of monoatomic ion transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: regulation of monoatomic ion transport is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0043679
    label: axon terminus
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: axon terminus is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0044326
    label: dendritic spine neck
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendritic spine neck is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0044327
    label: dendritic spine head
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendritic spine head is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein-containing complex binding is not wrong as a broad or downstream association,
      but it is not an informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0045211
    label: postsynaptic membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: postsynaptic membrane is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0045838
    label: positive regulation of membrane potential
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of membrane potential is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0048148
    label: behavioral response to cocaine
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered
      D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0050805
    label: negative regulation of synaptic transmission
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of synaptic transmission is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0051117
    label: ATPase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: ATPase binding captures a reported receptor complex or regulatory interaction rather
      than the core dopamine receptor activity.
    action: KEEP_AS_NON_CORE
    reason: The interaction may be biologically relevant for receptor trafficking, desensitization,
      or heteromer-specific signaling, but it is not the main Drd1 molecular function.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: glutamatergic synapse is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0099170
    label: postsynaptic modulation of chemical synaptic transmission
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: postsynaptic modulation of chemical synaptic transmission is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:1900038
    label: negative regulation of cellular response to hypoxia
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of cellular response to hypoxia is a downstream or specialized
      signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:1900273
    label: positive regulation of long-term synaptic potentiation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of long-term synaptic potentiation is a downstream or specialized
      signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:1901363
    label: heterocyclic compound binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: heterocyclic compound binding is not wrong as a broad or downstream association, but it
      is not an informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:2000253
    label: positive regulation of feeding behavior
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of feeding behavior is a mouse phenotype or circuit-level outcome
      of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0042734
    label: presynaptic membrane
  evidence_type: IDA
  original_reference_id: PMID:27035941
  review:
    summary: presynaptic membrane is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0045211
    label: postsynaptic membrane
  evidence_type: IDA
  original_reference_id: PMID:27035941
  review:
    summary: postsynaptic membrane is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:25258080
  review:
    summary: glutamatergic synapse is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: EXP
  original_reference_id: PMID:25258080
  review:
    summary: glutamatergic synapse is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:27035941
  review:
    summary: glutamatergic synapse is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0098982
    label: GABA-ergic synapse
  evidence_type: IDA
  original_reference_id: PMID:27035941
  review:
    summary: GABA-ergic synapse is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0099010
    label: modification of postsynaptic structure
  evidence_type: IDA
  original_reference_id: PMID:25258080
  review:
    summary: modification of postsynaptic structure is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0099010
    label: modification of postsynaptic structure
  evidence_type: EXP
  original_reference_id: PMID:25258080
  review:
    summary: modification of postsynaptic structure is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
  evidence_type: IDA
  original_reference_id: PMID:22586226
  review:
    summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized
      signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
  evidence_type: EXP
  original_reference_id: PMID:22586226
  review:
    summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized
      signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IGI
  original_reference_id: PMID:10884517
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0008542
    label: visual learning
  evidence_type: IMP
  original_reference_id: PMID:10884517
  review:
    summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:11923452
  review:
    summary: PMID:11923452 is an alpha1b-adrenergic receptor knockout study and uses D1 agonist
      response to assess compensation, not to directly test Drd1 adenylyl cyclase signaling.
    action: UNDECIDED
    reason: The term matches canonical Drd1 pathway biology, but this specific PMID is indirect and
      non-Drd1-centric, so the annotation should not be accepted from this evidence.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:12223546
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:12665504
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:17194762
  review:
    summary: PMID:17194762 supports D1-D2 heteromer signaling through Gq/11 and intracellular calcium
      release, not adenylyl-cyclase activation.
    action: MODIFY
    reason: The original term has the correct dopamine receptor signaling context but the wrong second
      messenger specificity for this PMID; use the phospholipase C/calcium dopamine receptor pathway
      already represented by the companion annotation.
    proposed_replacement_terms:
    - id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
- term:
    id: GO:0060158
    label: phospholipase C-activating dopamine receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:15016423
  review:
    summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0060158
    label: phospholipase C-activating dopamine receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:17194762
  review:
    summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0005929
    label: cilium
  evidence_type: ISO
  original_reference_id: PMID:28154160
  review:
    summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is
      secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25865831
  review:
    summary: protein binding is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0043197
    label: dendritic spine
  evidence_type: IDA
  original_reference_id: PMID:25865831
  review:
    summary: dendritic spine is supported as a localization or trafficking context for D1 receptor,
      but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:23842570
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23842570
  review:
    summary: protein binding is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0001932
    label: regulation of protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:18496528
  review:
    summary: regulation of protein phosphorylation is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:18496528
  review:
    summary: protein phosphorylation is a downstream or specialized signaling consequence of D1
      receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0006606
    label: protein import into nucleus
  evidence_type: EXP
  original_reference_id: PMID:18496528
  review:
    summary: protein import into nucleus is a downstream or specialized signaling consequence of D1
      receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27460146
  review:
    summary: protein binding is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24550737
  review:
    summary: protein binding is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0005783
    label: endoplasmic reticulum
  evidence_type: IDA
  original_reference_id: PMID:24550737
  review:
    summary: endoplasmic reticulum is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:24550737
  review:
    summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine
      receptor signaling.
    action: ACCEPT
    reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the
      plasma membrane.
    supported_by:
    - reference_id: PMID:24550737
      supporting_text: Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons.
- term:
    id: GO:0012505
    label: endomembrane system
  evidence_type: IDA
  original_reference_id: PMID:24550737
  review:
    summary: endomembrane system is supported as a localization or trafficking context for D1
      receptor, but it is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:11251190
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0042711
    label: maternal behavior
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0042711
    label: maternal behavior
  evidence_type: IMP
  original_reference_id: PMID:7809078
  review:
    summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0046959
    label: habituation
  evidence_type: IMP
  original_reference_id: PMID:11985822
  review:
    summary: habituation is retained as a non-core annotation pending more granular review of the
      original evidence.
    action: KEEP_AS_NON_CORE
    reason: The term is not the primary receptor activity, but the existing evidence does not
      justify removal.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IGI
  original_reference_id: PMID:21368124
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IDA
  original_reference_id: PMID:7809078
  review:
    summary: membrane is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IDA
  original_reference_id: PMID:8738226
  review:
    summary: membrane is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0016020
    label: membrane
  evidence_type: IDA
  original_reference_id: PMID:9016340
  review:
    summary: membrane is supported as a localization or trafficking context for D1 receptor, but it
      is secondary to the receptor signaling function.
    action: KEEP_AS_NON_CORE
    reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane
      trafficking, and ciliary localization evidence. These locations explain where signaling occurs
      but do not by themselves define the core molecular activity.
- term:
    id: GO:0009410
    label: response to xenobiotic stimulus
  evidence_type: IMP
  original_reference_id: PMID:11251190
  review:
    summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of
      altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0098708
    label: D-glucose import across plasma membrane
  evidence_type: IMP
  original_reference_id: PMID:11251190
  review:
    summary: D-glucose import across plasma membrane is a mouse phenotype or circuit-level outcome
      of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IMP
  original_reference_id: PMID:13679419
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IMP
  original_reference_id: PMID:9387887
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001659
    label: temperature homeostasis
  evidence_type: IMP
  original_reference_id: PMID:18486343
  review:
    summary: temperature homeostasis is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001661
    label: conditioned taste aversion
  evidence_type: IMP
  original_reference_id: PMID:15932618
  review:
    summary: conditioned taste aversion is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001662
    label: behavioral fear response
  evidence_type: IMP
  original_reference_id: PMID:11172752
  review:
    summary: behavioral fear response is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001963
    label: synaptic transmission, dopaminergic
  evidence_type: IMP
  original_reference_id: PMID:16908842
  review:
    summary: synaptic transmission, dopaminergic is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IMP
  original_reference_id: PMID:10222120
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IMP
  original_reference_id: PMID:10661513
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IGI
  original_reference_id: PMID:11823893
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IMP
  original_reference_id: PMID:16014726
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IMP
  original_reference_id: PMID:18486343
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IMP
  original_reference_id: PMID:9261820
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0004952
    label: dopamine neurotransmitter receptor activity
  evidence_type: IDA
  original_reference_id: PMID:18671743
  review:
    summary: 'dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function:
      dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate
      cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9016340
  review:
    summary: protein binding is not wrong as a broad or downstream association, but it is not an
      informative primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:9387887
  review:
    summary: nucleus is not wrong as a broad or downstream association, but it is not an informative
      primary annotation for Drd1.
    action: MARK_AS_OVER_ANNOTATED
    reason: The annotation either uses an overly generic binding/signaling term, a computationally
      inferred phenotype, or a downstream physiological outcome. The receptor-specific
      dopamine/Gs/cAMP annotations capture the gene product function more cleanly.
- term:
    id: GO:0006606
    label: protein import into nucleus
  evidence_type: IMP
  original_reference_id: PMID:18496528
  review:
    summary: protein import into nucleus is a downstream or specialized signaling consequence of D1
      receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0006936
    label: muscle contraction
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: muscle contraction is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007186
    label: G protein-coupled receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:11404425
  review:
    summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor
      signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:9016340
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:16908842
  review:
    summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1
      receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007612
    label: learning
  evidence_type: IMP
  original_reference_id: PMID:15684065
  review:
    summary: learning is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007613
    label: memory
  evidence_type: IMP
  original_reference_id: PMID:10585522
  review:
    summary: memory is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007625
    label: grooming behavior
  evidence_type: IMP
  original_reference_id: PMID:9749770
  review:
    summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:10222120
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:10661513
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:13679419
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:15684065
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:8001143
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:9261820
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IMP
  original_reference_id: PMID:9692749
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0008306
    label: associative learning
  evidence_type: IMP
  original_reference_id: PMID:9692749
  review:
    summary: associative learning is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0008542
    label: visual learning
  evidence_type: IMP
  original_reference_id: PMID:10585522
  review:
    summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0008542
    label: visual learning
  evidence_type: IMP
  original_reference_id: PMID:15684065
  review:
    summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0008542
    label: visual learning
  evidence_type: IMP
  original_reference_id: PMID:9692749
  review:
    summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0014002
    label: astrocyte development
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: astrocyte development is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0015872
    label: dopamine transport
  evidence_type: IMP
  original_reference_id: PMID:11404425
  review:
    summary: dopamine transport is a downstream or specialized signaling consequence of D1 receptor
      activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0019228
    label: neuronal action potential
  evidence_type: IMP
  original_reference_id: PMID:16908842
  review:
    summary: neuronal action potential is a downstream or specialized signaling consequence of D1
      receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0021542
    label: dentate gyrus development
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: dentate gyrus development is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0021756
    label: striatum development
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: striatum development is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0021766
    label: hippocampus development
  evidence_type: IMP
  original_reference_id: PMID:17360497
  review:
    summary: hippocampus development is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0035106
    label: operant conditioning
  evidence_type: IMP
  original_reference_id: PMID:12603275
  review:
    summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:10222120
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:10661513
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:12354293
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:16908842
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:18045908
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:9387887
  review:
    summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0046960
    label: sensitization
  evidence_type: IGI
  original_reference_id: PMID:11823893
  review:
    summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0048148
    label: behavioral response to cocaine
  evidence_type: IMP
  original_reference_id: PMID:16014726
  review:
    summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered
      D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0060291
    label: long-term synaptic potentiation
  evidence_type: IMP
  original_reference_id: PMID:13679419
  review:
    summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of
      altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0060291
    label: long-term synaptic potentiation
  evidence_type: IMP
  original_reference_id: PMID:14981263
  review:
    summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of
      altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0060291
    label: long-term synaptic potentiation
  evidence_type: IMP
  original_reference_id: PMID:9427321
  review:
    summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of
      altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0060292
    label: long-term synaptic depression
  evidence_type: IMP
  original_reference_id: PMID:14981263
  review:
    summary: long-term synaptic depression is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0051968
    label: positive regulation of synaptic transmission, glutamatergic
  evidence_type: IMP
  original_reference_id: PMID:8795639
  review:
    summary: positive regulation of synaptic transmission, glutamatergic is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:11069937
  review:
    summary: PMID:11069937 is a D2L receptor-deficient mouse study and does not directly test Drd1
      Gs-coupled receptor activity.
    action: UNDECIDED
    reason: The term matches Drd1 core molecular function, but this specific evidence is indirect and
      D2-centric, so the annotation should not be accepted from this PMID without direct Drd1 support.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IGI
  original_reference_id: PMID:11150348
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:11089973
  review:
    summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1
      receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0042053
    label: regulation of dopamine metabolic process
  evidence_type: IMP
  original_reference_id: PMID:11438590
  review:
    summary: regulation of dopamine metabolic process is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0007626
    label: locomotory behavior
  evidence_type: IGI
  original_reference_id: PMID:15272078
  review:
    summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007631
    label: feeding behavior
  evidence_type: IGI
  original_reference_id: PMID:15272078
  review:
    summary: feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0030432
    label: peristalsis
  evidence_type: IGI
  original_reference_id: PMID:15272078
  review:
    summary: peristalsis is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0021853
    label: cerebral cortex GABAergic interneuron migration
  evidence_type: IMP
  original_reference_id: PMID:17409246
  review:
    summary: cerebral cortex GABAergic interneuron migration is a mouse phenotype or circuit-level
      outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0030335
    label: positive regulation of cell migration
  evidence_type: IMP
  original_reference_id: PMID:17409246
  review:
    summary: positive regulation of cell migration is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0060158
    label: phospholipase C-activating dopamine receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or
      specialized signaling consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0007625
    label: grooming behavior
  evidence_type: IMP
  original_reference_id: PMID:9988094
  review:
    summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:12097513
  review:
    summary: PMID:12097513 examines D2/D3 mutant responses to D1 agonist challenge and working-memory
      rescue, but the cached abstract does not directly demonstrate Drd1 Gs-coupled receptor activity.
    action: UNDECIDED
    reason: Direct Drd1 molecular-function support would require full-text confirmation; the available
      abstract supports indirect D1-mediated physiological context rather than direct Gs coupling.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:7566118
  review:
    summary: PMID:7566118 is a D2 receptor knockout study and does not provide direct cached support
      for Drd1 Gs-coupled molecular activity.
    action: UNDECIDED
    reason: The accessible abstract supports dopaminergic-system physiology centered on D2 receptor
      deficiency, not direct Drd1 receptor activity; full-text evidence would be needed.
- term:
    id: GO:0001975
    label: response to amphetamine
  evidence_type: IGI
  original_reference_id: PMID:12097513
  review:
    summary: response to amphetamine is a downstream behavioral, pharmacological, or
      synaptic-plasticity outcome of altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but
      it represents a neural-circuit or organismal consequence rather than Drd1 core molecular
      function.
- term:
    id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:12097513
  review:
    summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1
      receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0007628
    label: adult walking behavior
  evidence_type: IGI
  original_reference_id: PMID:12652349
  review:
    summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007628
    label: adult walking behavior
  evidence_type: IMP
  original_reference_id: PMID:7954836
  review:
    summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0007628
    label: adult walking behavior
  evidence_type: IGI
  original_reference_id: PMID:9354330
  review:
    summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1
      receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:16962565
  review:
    summary: PMID:16962565 analyzes SCH23390 binding states and D2/A2A receptor involvement; the
      cached abstract does not directly establish Drd1 Gs-coupled receptor activity.
    action: UNDECIDED
    reason: The abstract distinguishes binding components including sites independent of D1 expression,
      so direct Drd1 molecular-function support requires full-text confirmation.
- term:
    id: GO:0004952
    label: dopamine neurotransmitter receptor activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: 'dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function:
      dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate
      cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
- term:
    id: GO:0007617
    label: mating behavior
  evidence_type: IDA
  original_reference_id: PMID:9829800
  review:
    summary: mating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor
      signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0004930
    label: G protein-coupled receptor activity
  evidence_type: IDA
  original_reference_id: PMID:14712229
  review:
    summary: G protein-coupled receptor activity is a correct parent-level molecular function for
      Drd1, though the dopamine- and Gs-coupled terms are more informative.
    action: ACCEPT
    reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific
      representation.
- term:
    id: GO:0007186
    label: G protein-coupled receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:14712229
  review:
    summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor
      signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:12930822
  review:
    summary: PMID:12930822 reports parkin-deficient mouse nigrostriatal phenotypes and dopamine
      regulation; the cached abstract does not directly support Drd1 Gs-coupled molecular activity.
    action: UNDECIDED
    reason: The available evidence is indirect dopaminergic-system context; full-text confirmation
      would be needed before accepting this as a Drd1 molecular-function annotation.
- term:
    id: GO:0019226
    label: transmission of nerve impulse
  evidence_type: IMP
  original_reference_id: PMID:12867509
  review:
    summary: transmission of nerve impulse is a downstream or specialized signaling consequence of
      D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0007190
    label: activation of adenylate cyclase activity
  evidence_type: IDA
  original_reference_id: PMID:12488442
  review:
    summary: activation of adenylate cyclase activity is a downstream or specialized signaling
      consequence of D1 receptor activity.
    action: KEEP_AS_NON_CORE
    reason: This term is consistent with experimental or orthology-supported literature, especially
      synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated
      as the core function in place of dopamine receptor/G protein coupling.
- term:
    id: GO:0009410
    label: response to xenobiotic stimulus
  evidence_type: IDA
  original_reference_id: PMID:7549459
  review:
    summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of
      altered D1 receptor signaling.
    action: KEEP_AS_NON_CORE
    reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses,
      development, and synaptic plasticity, but these are downstream organismal or neural-circuit
      consequences rather than the gene product core function.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IMP
  original_reference_id: PMID:7809078
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:7954836
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:8294904
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  evidence_type: IDA
  original_reference_id: PMID:8738226
  review:
    summary: 'dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular
      function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to
      initiate cAMP signaling.'
    action: ACCEPT
    reason: This directly describes receptor ligand recognition or proximal G protein coupling
      rather than a downstream behavioral phenotype.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
- term:
    id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:8738226
  review:
    summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the
      canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation.
    action: ACCEPT
    reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine
      receptors; broader GPCR signaling parents are correct but less specific.
    supported_by:
    - reference_id: UniProtKB:Q61616
      supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
        adenylyl cyclase.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000008
  title: Gene Ontology annotation by the MGI curatorial staff, curated orthology
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000043
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary
    mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat
    orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using
    Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human
    orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10222120
  title: Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice.
  findings: []
- id: PMID:10585522
  title: Spatial learning deficit in dopamine D(1) receptor knockout mice.
  findings: []
- id: PMID:10661513
  title: Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine
    D1 receptor.
  findings: []
- id: PMID:10884517
  title: Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine
    D(1) and D(3) receptors.
  findings: []
- id: PMID:11069937
  title: Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent
    functions.
  findings: []
- id: PMID:11089973
  title: Distinct functions of the two isoforms of dopamine D2 receptors.
  findings: []
- id: PMID:11150348
  title: 'Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out
    mice: differential effects of D1 and D2 receptor antagonists.'
  findings: []
- id: PMID:11172752
  title: Prolonged fear responses in mice lacking dopamine D1 receptor.
  findings: []
- id: PMID:11251190
  title: Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors.
  findings: []
- id: PMID:11404425
  title: Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine
    action in the striatum.
  findings: []
- id: PMID:11438590
  title: The role of dopamine receptors in regulating the size of axonal arbors.
  findings: []
- id: PMID:11823893
  title: 'Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A
    receptor knockout mice.'
  findings: []
- id: PMID:11923452
  title: Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants
    and opiates.
  findings:
  - statement: D1 agonist response was used to rule out basal dopaminergic compensation in alpha1b-adrenergic
      receptor knockout mice, not to directly test Drd1 adenylyl-cyclase signaling.
    supporting_text: Because catecholamine tissue levels, autoradiography of D1 and D2 dopaminergic
      receptors, and of dopamine reuptake sites and locomotor response to a D1 agonist showed that
      basal dopaminergic transmission was similar in knock-out and wild-type mice
- id: PMID:11985822
  title: Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement
    topographies in congenic dopamine D1A receptor 'knockout' mice.
  findings: []
- id: PMID:12097513
  title: Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits.
  findings: []
- id: PMID:12223546
  title: Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.
  findings:
  - statement: Type 5 adenylyl cyclase loss eliminates most striatal D1 agonist-stimulated adenylyl
      cyclase activity, supporting D1 receptor coupling to AC5/cAMP signaling.
    supporting_text: The genetic ablation of the AC5 gene eliminated >80% of forskolin-induced AC
      activity and 85-90% of AC activity stimulated by either D1 or A2A receptor agonists in striatum.
  - statement: AC5 is presented as a striatal signaling integrator for D1, D2, and A2A receptors.
    supporting_text: Together, these results suggest that AC5 is the principal AC integrating signals
      from multiple receptors including D1, D2, and A2A in striatum
- id: PMID:12354293
  title: The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression.
  findings: []
- id: PMID:12488442
  title: Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP
    production.
  findings: []
- id: PMID:12603275
  title: Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice.
  findings: []
- id: PMID:12652349
  title: Essential conservation of D1 mutant phenotype at the level of individual topographies of
    behaviour in mice lacking both D1 and D3 dopamine receptors.
  findings: []
- id: PMID:12665504
  title: Motor dysfunction in type 5 adenylyl cyclase-null mice.
  findings:
  - statement: D1 dopaminergic agonist-stimulated adenylyl cyclase activity is attenuated in AC5-null
      striatum, supporting Drd1/AC5/cAMP pathway coupling.
    supporting_text: D1 dopaminergic agonist-stimulated adenylyl cyclase activity was attenuated,
      and this was accompanied by a decrease in the expression of the D1 dopaminergic receptor and
      G(s)alpha.
  - statement: D1 stimulation partially compensates through remnant adenylyl cyclase isoforms in
      AC5-null mice.
    supporting_text: Selective D1 or D2 dopaminergic stimulation improved some of these disorders
      in this mouse model, suggesting the partial compensation of each dopaminergic receptor signal
      through the stimulation of remnant adenylyl cyclase isoforms.
- id: PMID:12867509
  title: Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on
    striatal interneurons.
  findings: []
- id: PMID:12930822
  title: Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.
  findings: []
- id: PMID:13679419
  title: Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic
    plasticity.
  findings: []
- id: PMID:14712229
  title: 'G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai
    regulated pathway.'
  findings: []
- id: PMID:14981263
  title: Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal
    cortex by D1 receptors.
  findings: []
- id: PMID:15016423
  title: Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking
    dopamine D3 receptor.
  findings: []
- id: PMID:15272078
  title: Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice.
  findings: []
- id: PMID:15684065
  title: Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to
    prediction of reward associated with place.
  findings: []
- id: PMID:15932618
  title: Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned
    taste aversion for salt but not sucrose.
  findings: []
- id: PMID:16014726
  title: Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents
    cocaine sensitization and decreases cocaine preference.
  findings: []
- id: PMID:16908842
  title: Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to
    endocytic vesicles.
  findings: []
- id: PMID:16962565
  title: 'Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction
    with A2A and D2-like receptors.'
  findings: []
- id: PMID:17194762
  title: D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid
    activation of Gq/11 in the striatum.
  findings:
  - statement: D1-D2 receptor heteromers can couple to Gq/11 and intracellular calcium release,
      supporting PLC/calcium annotations as specialized non-core signaling contexts.
- id: PMID:17360497
  title: Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia,
    hyperactivity, and impaired oral behavior.
  findings: []
- id: PMID:17409246
  title: Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to
    the cerebral cortex.
  findings: []
- id: PMID:18045908
  title: Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.
  findings: []
- id: PMID:18486343
  title: 'Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors.'
  findings: []
- id: PMID:18496528
  title: A phosphatase cascade by which rewarding stimuli control nucleosomal response.
  findings: []
- id: PMID:18671743
  title: Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation,
    dopamine transporter binding and behavioural sensitization in brains of mice treated with a
    chronic escalating dose 'binge' cocaine administration paradigm.
  findings: []
- id: PMID:21368124
  title: Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium
    spiny neurons is required for amphetamine sensitization.
  findings: []
- id: PMID:22586226
  title: Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens
    core.
  findings: []
- id: PMID:23842570
  title: Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs
    D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human
    embryonic kidney 293T cells.
  findings: []
- id: PMID:24550737
  title: Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal
    D1 neurons.
  findings:
  - statement: SLC35D3 interacts with D1R and affects ER exit and surface levels, supporting
      ER/endomembrane trafficking annotations as non-core receptor handling.
- id: PMID:25258080
  title: A critical time window for dopamine actions on the structural plasticity of dendritic
    spines.
  findings: []
- id: PMID:25865831
  title: Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic
    spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus.
  findings: []
- id: PMID:26053317
  title: Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible
    Involvement in Body Weight Control.
  findings: []
- id: PMID:27035941
  title: Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and
    GABAergic postsynaptic structures.
  findings: []
- id: PMID:27460146
  title: VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.
  findings:
  - statement: VPS35 regulates DRD1 surface recycling and CREB/ERK signaling, supporting trafficking
      and downstream phosphorylation annotations as non-core.
- id: PMID:28154160
  title: Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
  findings:
  - statement: TULP3/TUB adapter work supports D1R ciliary trafficking as a specialized localization
      context.
- id: PMID:7549459
  title: Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in morphine tolerance and
    dependence in mice.
  findings: []
- id: PMID:7566118
  title: Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors.
  findings: []
- id: PMID:7809078
  title: Altered striatal function in a mutant mouse lacking D1A dopamine receptors.
  findings: []
- id: PMID:7954836
  title: Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in
    dopamine-mediated behavioral responses.
  findings: []
- id: PMID:8001143
  title: Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological
    effects in dopamine D1 receptor mutant mice.
  findings:
  - statement: D1 receptor mutant mice lack cocaine-induced locomotor stimulation and show reduced
      dopamine-mediated nucleus accumbens neurophysiology, supporting downstream drug-response and
      locomotor annotations as non-core phenotypes.
- id: PMID:8294904
  title: Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density,
    rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors.
  findings: []
- id: PMID:8738226
  title: Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid
    receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors.
  findings: []
- id: PMID:8795639
  title: Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in
    D1A-deficient mutant mice.
  findings: []
- id: PMID:9016340
  title: 'D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine
    receptors: evidence from D1A knockout mice.'
  findings: []
- id: PMID:9261820
  title: Effects of repeated amphetamine treatment on the locomotor activity of the dopamine
    D1A-deficient mouse.
  findings: []
- id: PMID:9354330
  title: Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent
    stimulation of D1 and D2 receptors.
  findings: []
- id: PMID:9387887
  title: 'D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with
    targeted deletion of the D1 dopamine receptor gene.'
  findings: []
- id: PMID:9427321
  title: Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term
    potentiation.
  findings:
  - statement: D1-deficient mice show loss of late-phase hippocampal LTP, supporting synaptic
      plasticity annotations as circuit-level consequences of receptor signaling.
- id: PMID:9692749
  title: Behavioural assessment of mice lacking D1A dopamine receptors.
  findings: []
- id: PMID:9749770
  title: Action sequencing is impaired in D1A-deficient mutant mice.
  findings: []
- id: PMID:9829800
  title: Dopamine-stimulated sexual behavior is testosterone dependent in mice.
  findings: []
- id: PMID:9988094
  title: The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2
    receptor-deficient mice.
  findings: []
- id: UniProtKB:Q61616
  title: UniProt record for mouse Drd1 (Q61616)
  findings:
  - statement: Drd1 is a dopamine receptor mediated by G proteins that activate adenylyl cyclase.
  - statement: UniProt places Drd1 at cell membrane, ER membrane, ciliary membrane, dendrite, and
      dendritic spine contexts.
- id: file:mouse/Drd1/Drd1-deep-research-falcon.md
  title: Falcon deep research summary for mouse Drd1
  findings:
  - statement: Falcon synthesis supports Drd1 as a D1-like class A GPCR whose core
      output is Gs/Golf-mediated adenylyl cyclase activation and cAMP/PKA signaling.
  - statement: Falcon synthesis treats ciliary, endosomal, dendritic-spine, and
      receptor-complex signaling as important but context-specific Drd1 biology.
core_functions:
- molecular_function:
    id: GO:0001588
    label: dopamine neurotransmitter receptor activity, coupled via Gs
  description: Binds dopamine as a D1-like class A GPCR and activates Gs/Golf-coupled signaling.
  locations:
  - id: GO:0005886
    label: plasma membrane
  directly_involved_in:
  - id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  - id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  supported_by:
  - reference_id: UniProtKB:Q61616
    supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
      adenylyl cyclase.
  - reference_id: file:mouse/Drd1/Drd1-deep-research-falcon.md
    supporting_text: Falcon synthesis identifies D1 receptor signaling through
      Gs/Golf, adenylyl cyclase, cAMP, and PKA as the canonical Drd1 pathway.
- molecular_function:
    id: GO:0035240
    label: dopamine binding
  description: Recognizes dopamine ligand through the conserved D1 receptor seven-transmembrane
    binding pocket.
  locations:
  - id: GO:0005886
    label: plasma membrane
  directly_involved_in:
  - id: GO:0007212
    label: G protein-coupled dopamine receptor signaling pathway
  supported_by:
  - reference_id: UniProtKB:Q61616
    supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
      adenylyl cyclase.
  - reference_id: file:mouse/Drd1/Drd1-deep-research-falcon.md
    supporting_text: Falcon synthesis supports dopamine sensing by the D1 receptor
      seven-transmembrane binding pocket as the initiating molecular function.
- molecular_function:
    id: GO:0001965
    label: G-protein alpha-subunit binding
  description: Couples activated receptor to heterotrimeric Gs/Golf proteins to drive adenylyl
    cyclase activation and cAMP signaling.
  locations:
  - id: GO:0005886
    label: plasma membrane
  directly_involved_in:
  - id: GO:0007189
    label: adenylate cyclase-activating G protein-coupled receptor signaling pathway
  - id: GO:0007191
    label: adenylate cyclase-activating dopamine receptor signaling pathway
  supported_by:
  - reference_id: UniProtKB:Q61616
    supporting_text: Dopamine receptor whose activity is mediated by G proteins which activate
      adenylyl cyclase.
  - reference_id: file:mouse/Drd1/Drd1-deep-research-falcon.md
    supporting_text: Falcon synthesis supports coupling of activated Drd1 to Gs/Golf
      proteins as the route to adenylyl cyclase activation and cAMP signaling.
proposed_new_terms: []
suggested_questions:
- question: Which Drd1 annotations from whole-animal knockout or drug-response studies should remain
    GO biological process annotations versus be treated only as mouse phenotype evidence?
- question: Should D1-D2 heteromer-specific PLC/calcium signaling be annotated to Drd1 generally, or
    only in contexts where heteromer formation is directly demonstrated?
- question: Which neuronal compartments have endogenous Drd1 protein evidence in mouse rather than
    overexpression or orthology-transfer evidence?
suggested_experiments:
- description: Measure endogenous Drd1 localization and signaling at plasma membrane, dendritic
    spine, and ciliary compartments using tagged knock-in Drd1 mice.
  hypothesis: Some specialized ciliary and synaptic annotations reflect context-specific receptor
    pools rather than general Drd1 localization.
  experiment_type: Endogenous tagging with quantitative imaging and cAMP biosensors
- description: Separate Gs/Golf and D1-D2 heteromer signaling with receptor mutants or
    cell-type-specific rescue in striatal medium spiny neurons.
  hypothesis: Canonical Drd1 signaling is Gs/Golf-cAMP mediated, while PLC/calcium terms require
    heteromer-specific context.
  experiment_type: Cell-type-specific genetic rescue and second-messenger assays

Drd1

Gene Description

Existing Annotations Review

Core Functions

Binds dopamine as a D1-like class A GPCR and activates Gs/Golf-coupled signaling.

Recognizes dopamine ligand through the conserved D1 receptor seven-transmembrane binding pocket.

Couples activated receptor to heterotrimeric Gs/Golf proteins to drive adenylyl cyclase activation and cAMP signaling.

References

Suggested Questions for Experts

Suggested Experiments

📚 Additional Documentation

Deep Research Falcon

Question

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

Target Gene/Protein Identity (from UniProt):

MANDATORY VERIFICATION STEPS:

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Output

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

Target Gene/Protein Identity (from UniProt):

MANDATORY VERIFICATION STEPS:

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Research Report: Mouse Drd1 (Dopamine D1 receptor; UniProt Q61616)

0) Target verification (mandatory)

1) Key concepts & definitions (current understanding)

1.1 What DRD1 is

1.2 Canonical signaling definition: “D1-like” pathway

1.3 Modern view: signaling is spatiotemporally compartmentalized

2) Molecular function: what DRD1 “does” biochemically

2.1 Primary molecular function

2.2 Downstream effectors and pathway integration

3) Cellular & subcellular localization

3.1 Brain-region and cell-type localization

3.2 Synaptic and postsynaptic-density localization; glutamatergic integration

3.3 Intracellular pools: endosomes, Golgi-adjacent signaling, and primary cilia

4) Recent developments and latest research (prioritized 2023–2024)

4.1 Negative regulation of D1R→PKA signaling by LRRK2 (2024)

4.2 Spatial organization of cAMP generation and nuclear PKA bias via AC9 endosomes (2024)

4.3 In vivo receptor-proximal proteomics to map D1 microenvironment (2024)

4.4 Evolving understanding of noncanonical signaling and receptor complexes (2024)

5) Current applications and real-world implementations

5.1 Cell-type specific genetics (Drd1-Cre) and pathway dissection

5.2 Quantitative live imaging of the canonical D1→PKA axis

5.3 Chemogenetic tuning of dopamine sensors (2024)

5.4 PET imaging of D1 receptors as a translational bridge

6) Quantitative statistics and data points (recent studies)

7) Expert synthesis (authoritative analysis from reviews and high-impact studies)

8) Evidence figure supporting compartmentalized D1-linked cAMP/PKA signaling

9) Summary table (functional annotation at a glance)

Citations

Notes

Drd1 review notes

📄 View Raw YAML