Drd1

id: Q61616
gene_symbol: Drd1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Drd1'
existing_annotations:
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071880
      label: adenylate cyclase-activating adrenergic receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007212
      label: G protein-coupled dopamine receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004952
      label: dopamine neurotransmitter receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005789
      label: endoplasmic reticulum membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007189
      label: adenylate cyclase-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008306
      label: associative learning
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042311
      label: vasodilation
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043197
      label: dendritic spine
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046960
      label: sensitization
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060170
      label: ciliary membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060292
      label: long-term synaptic depression
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0120025
      label: plasma membrane bounded cell projection
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001965
      label: G-protein alpha-subunit binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007187
      label: G protein-coupled receptor signaling pathway, coupled to cyclic 
        nucleotide second messenger
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007189
      label: adenylate cyclase-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032795
      label: heterotrimeric G-protein binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035240
      label: dopamine binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051281
      label: positive regulation of release of sequestered calcium ion into 
        cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060170
      label: ciliary membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071870
      label: cellular response to catecholamine stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097648
      label: G protein-coupled receptor complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097730
      label: non-motile cilium
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990763
      label: arrestin family protein binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001965
      label: G-protein alpha-subunit binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005929
      label: cilium
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007187
      label: G protein-coupled receptor signaling pathway, coupled to cyclic 
        nucleotide second messenger
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032795
      label: heterotrimeric G-protein binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035240
      label: dopamine binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051281
      label: positive regulation of release of sequestered calcium ion into 
        cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071870
      label: cellular response to catecholamine stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097648
      label: G protein-coupled receptor complex
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097730
      label: non-motile cilium
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990763
      label: arrestin family protein binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097731
      label: 9+0 non-motile cilium
    evidence_type: IDA
    original_reference_id: PMID:26053317
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26053317
          supporting_text: eCollection 2015. Identification of G Protein-Coupled
            Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in
            Body Weight Control.
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006469
      label: negative regulation of protein kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001965
      label: G-protein alpha-subunit binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005901
      label: caveola
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006886
      label: intracellular protein transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007625
      label: grooming behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008306
      label: associative learning
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019229
      label: regulation of vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019722
      label: calcium-mediated signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019903
      label: protein phosphatase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030336
      label: negative regulation of cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030424
      label: axon
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030425
      label: dendrite
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031701
      label: angiotensin receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031750
      label: D3 dopamine receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035106
      label: operant conditioning
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035176
      label: social behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035240
      label: dopamine binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042321
      label: negative regulation of circadian sleep/wake cycle, sleep
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042734
      label: presynaptic membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042755
      label: eating behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043197
      label: dendritic spine
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043198
      label: dendritic shaft
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043269
      label: regulation of monoatomic ion transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043679
      label: axon terminus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044326
      label: dendritic spine neck
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044327
      label: dendritic spine head
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044877
      label: protein-containing complex binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045211
      label: postsynaptic membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045838
      label: positive regulation of membrane potential
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048148
      label: behavioral response to cocaine
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050805
      label: negative regulation of synaptic transmission
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051117
      label: ATPase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0099170
      label: postsynaptic modulation of chemical synaptic transmission
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900038
      label: negative regulation of cellular response to hypoxia
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900273
      label: positive regulation of long-term synaptic potentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1901363
      label: heterocyclic compound binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000253
      label: positive regulation of feeding behavior
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042734
      label: presynaptic membrane
    evidence_type: IDA
    original_reference_id: PMID:27035941
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27035941
          supporting_text: Dopamine synapse is a neuroligin-2-mediated contact 
            between dopaminergic presynaptic and GABAergic postsynaptic 
            structures.
  - term:
      id: GO:0045211
      label: postsynaptic membrane
    evidence_type: IDA
    original_reference_id: PMID:27035941
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27035941
          supporting_text: Dopamine synapse is a neuroligin-2-mediated contact 
            between dopaminergic presynaptic and GABAergic postsynaptic 
            structures.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IDA
    original_reference_id: PMID:25258080
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25258080
          supporting_text: A critical time window for dopamine actions on the 
            structural plasticity of dendritic spines.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: EXP
    original_reference_id: PMID:25258080
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25258080
          supporting_text: A critical time window for dopamine actions on the 
            structural plasticity of dendritic spines.
  - term:
      id: GO:0098978
      label: glutamatergic synapse
    evidence_type: IDA
    original_reference_id: PMID:27035941
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27035941
          supporting_text: Dopamine synapse is a neuroligin-2-mediated contact 
            between dopaminergic presynaptic and GABAergic postsynaptic 
            structures.
  - term:
      id: GO:0098982
      label: GABA-ergic synapse
    evidence_type: IDA
    original_reference_id: PMID:27035941
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27035941
          supporting_text: Dopamine synapse is a neuroligin-2-mediated contact 
            between dopaminergic presynaptic and GABAergic postsynaptic 
            structures.
  - term:
      id: GO:0099010
      label: modification of postsynaptic structure
    evidence_type: IDA
    original_reference_id: PMID:25258080
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25258080
          supporting_text: A critical time window for dopamine actions on the 
            structural plasticity of dendritic spines.
  - term:
      id: GO:0099010
      label: modification of postsynaptic structure
    evidence_type: EXP
    original_reference_id: PMID:25258080
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25258080
          supporting_text: A critical time window for dopamine actions on the 
            structural plasticity of dendritic spines.
  - term:
      id: GO:0099171
      label: presynaptic modulation of chemical synaptic transmission
    evidence_type: IDA
    original_reference_id: PMID:22586226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22586226
          supporting_text: Epub 2012 May 14. Regulation of prefrontal excitatory
            neurotransmission by dopamine in the nucleus accumbens core.
  - term:
      id: GO:0099171
      label: presynaptic modulation of chemical synaptic transmission
    evidence_type: EXP
    original_reference_id: PMID:22586226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22586226
          supporting_text: Epub 2012 May 14. Regulation of prefrontal excitatory
            neurotransmission by dopamine in the nucleus accumbens core.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IGI
    original_reference_id: PMID:10884517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10884517
          supporting_text: Modification of dopamine D(1) receptor knockout 
            phenotype in mice lacking both dopamine D(1) and D(3) receptors.
  - term:
      id: GO:0008542
      label: visual learning
    evidence_type: IMP
    original_reference_id: PMID:10884517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10884517
          supporting_text: Modification of dopamine D(1) receptor knockout 
            phenotype in mice lacking both dopamine D(1) and D(3) receptors.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:11923452
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11923452
          supporting_text: Alpha1b-adrenergic receptors control locomotor and 
            rewarding effects of psychostimulants and opiates.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:12223546
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12223546
          supporting_text: Impaired D2 dopamine receptor function in mice 
            lacking type 5 adenylyl cyclase.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:12665504
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12665504
          supporting_text: 2003 Mar 28. Motor dysfunction in type 5 adenylyl 
            cyclase-null mice.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:17194762
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17194762
          supporting_text: D1-D2 dopamine receptor heterooligomers with unique 
            pharmacology are coupled to rapid activation of Gq/11 in the 
            striatum.
  - term:
      id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:15016423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15016423
          supporting_text: Enhancement of dopamine-induced signaling responses 
            in the forebrain of mice lacking dopamine D3 receptor.
  - term:
      id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:17194762
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17194762
          supporting_text: D1-D2 dopamine receptor heterooligomers with unique 
            pharmacology are coupled to rapid activation of Gq/11 in the 
            striatum.
  - term:
      id: GO:0005929
      label: cilium
    evidence_type: ISO
    original_reference_id: PMID:28154160
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28154160
          supporting_text: Feb 2. Tubby family proteins are adapters for ciliary
            trafficking of integral membrane proteins.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25865831
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25865831
          supporting_text: Drebrin depletion alters neurotransmitter receptor 
            levels in protein complexes, dendritic spine morphogenesis and 
            memory-related synaptic plasticity in the mouse hippocampus.
  - term:
      id: GO:0043197
      label: dendritic spine
    evidence_type: IDA
    original_reference_id: PMID:25865831
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25865831
          supporting_text: Drebrin depletion alters neurotransmitter receptor 
            levels in protein complexes, dendritic spine morphogenesis and 
            memory-related synaptic plasticity in the mouse hippocampus.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:23842570
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23842570
          supporting_text: Jul 10. Prostaglandin E receptor EP1 forms a complex 
            with dopamine D1 receptor and directs D1-induced cAMP production to 
            adenylyl cyclase 7 through mobilizing G(βγ) subunits in human 
            embryonic kidney 293T cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:23842570
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23842570
          supporting_text: Jul 10. Prostaglandin E receptor EP1 forms a complex 
            with dopamine D1 receptor and directs D1-induced cAMP production to 
            adenylyl cyclase 7 through mobilizing G(βγ) subunits in human 
            embryonic kidney 293T cells.
  - term:
      id: GO:0001932
      label: regulation of protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:18496528
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18496528
          supporting_text: A phosphatase cascade by which rewarding stimuli 
            control nucleosomal response.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:18496528
    review:
      summary: >-
        OVER-ANNOTATION: D1 receptor (GPCR) does not perform phosphorylation itself.
        PMID:18496528 shows D1R activation leads to a signaling cascade (D1R → cAMP
        → PP2A →
        DARPP-32 dephosphorylation → nuclear accumulation → PP1 inhibition → H3 phosphorylation),
        but the actual phosphorylation is performed by downstream kinases, not by
        D1R.
        The receptor regulates phosphorylation through signaling, it does not catalyze
        it.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:18496528
          supporting_text: A phosphatase cascade by which rewarding stimuli 
            control nucleosomal response.
  - term:
      id: GO:0006606
      label: protein import into nucleus
    evidence_type: EXP
    original_reference_id: PMID:18496528
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18496528
          supporting_text: A phosphatase cascade by which rewarding stimuli 
            control nucleosomal response.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:27460146
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27460146
          supporting_text: Epub 2016 May 21. VPS35 regulates cell surface 
            recycling and signaling of dopamine receptor D1.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:24550737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24550737
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0005783
      label: endoplasmic reticulum
    evidence_type: IDA
    original_reference_id: PMID:24550737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24550737
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:24550737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24550737
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0012505
      label: endomembrane system
    evidence_type: IDA
    original_reference_id: PMID:24550737
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24550737
          supporting_text: eCollection 2014 Feb.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:11251190
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11251190
          supporting_text: Blunted brain metabolic response to ketamine in mice 
            lacking D(1A) dopamine receptors.
  - term:
      id: GO:0042711
      label: maternal behavior
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0042711
      label: maternal behavior
    evidence_type: IMP
    original_reference_id: PMID:7809078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7809078
          supporting_text: Altered striatal function in a mutant mouse lacking 
            D1A dopamine receptors.
  - term:
      id: GO:0046959
      label: habituation
    evidence_type: IMP
    original_reference_id: PMID:11985822
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11985822
          supporting_text: Phenotypic resolution of spontaneous and D1-like 
            agonist-induced orofacial movement topographies in congenic dopamine
            D1A receptor 'knockout' mice.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IGI
    original_reference_id: PMID:21368124
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21368124
          supporting_text: Balanced NMDA receptor activity in dopamine D1 
            receptor (D1R)- and D2R-expressing medium spiny neurons is required 
            for amphetamine sensitization.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IDA
    original_reference_id: PMID:7809078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7809078
          supporting_text: Altered striatal function in a mutant mouse lacking 
            D1A dopamine receptors.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IDA
    original_reference_id: PMID:8738226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8738226
          supporting_text: Differences among mouse strains in the regulation by 
            mu, delta 1 and delta 2 opioid receptors of striatal adenylyl 
            cyclases activated by dopamine D1 or adenosine A2a receptors.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IDA
    original_reference_id: PMID:9016340
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9016340
          supporting_text: 'D1-like dopaminergic activation of phosphoinositide hydrolysis
            is independent of D1A dopamine receptors: evidence from D1A knockout mice.'
  - term:
      id: GO:0009410
      label: response to xenobiotic stimulus
    evidence_type: IMP
    original_reference_id: PMID:11251190
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11251190
          supporting_text: Blunted brain metabolic response to ketamine in mice 
            lacking D(1A) dopamine receptors.
  - term:
      id: GO:0098708
      label: D-glucose import across plasma membrane
    evidence_type: IMP
    original_reference_id: PMID:11251190
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11251190
          supporting_text: Blunted brain metabolic response to ketamine in mice 
            lacking D(1A) dopamine receptors.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IMP
    original_reference_id: PMID:13679419
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:13679419
          supporting_text: Distinct roles of D1 and D5 dopamine receptors in 
            motor activity and striatal synaptic plasticity.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IMP
    original_reference_id: PMID:9387887
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9387887
          supporting_text: 'D1 receptors mediate dopamine action in the fetal suprachiasmatic
            nuclei: studies of mice with targeted deletion of the D1 dopamine receptor
            gene.'
  - term:
      id: GO:0001659
      label: temperature homeostasis
    evidence_type: IMP
    original_reference_id: PMID:18486343
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18486343
          supporting_text: 'Epub 2008 Apr 16. Hyperthermic and lethal effects of methamphetamine:
            roles of dopamine D1 and D2 receptors.'
  - term:
      id: GO:0001661
      label: conditioned taste aversion
    evidence_type: IMP
    original_reference_id: PMID:15932618
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15932618
          supporting_text: Mice lacking dopamine D1 receptors express normal 
            lithium chloride-induced conditioned taste aversion for salt but not
            sucrose.
  - term:
      id: GO:0001662
      label: behavioral fear response
    evidence_type: IMP
    original_reference_id: PMID:11172752
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11172752
          supporting_text: Prolonged fear responses in mice lacking dopamine D1 
            receptor.
  - term:
      id: GO:0001963
      label: synaptic transmission, dopaminergic
    evidence_type: IMP
    original_reference_id: PMID:16908842
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16908842
          supporting_text: Binding of internalized receptors to the PDZ domain 
            of GIPC/synectin recruits myosin VI to endocytic vesicles.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:10222120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10222120
          supporting_text: Paradoxical locomotor behavior of dopamine D1 
            receptor transgenic mice.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:10661513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10661513
          supporting_text: Behavioral responses to cocaine and amphetamine 
            administration in mice lacking the dopamine D1 receptor.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IGI
    original_reference_id: PMID:11823893
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823893
          supporting_text: 'Role of D1-like receptors in amphetamine-induced behavioral
            sensitization: a study using D1A receptor knockout mice.'
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:16014726
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16014726
          supporting_text: Expression of mutant NMDA receptors in dopamine D1 
            receptor-containing cells prevents cocaine sensitization and 
            decreases cocaine preference.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:18486343
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18486343
          supporting_text: 'Epub 2008 Apr 16. Hyperthermic and lethal effects of methamphetamine:
            roles of dopamine D1 and D2 receptors.'
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:9261820
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9261820
          supporting_text: Effects of repeated amphetamine treatment on the 
            locomotor activity of the dopamine D1A-deficient mouse.
  - term:
      id: GO:0004952
      label: dopamine neurotransmitter receptor activity
    evidence_type: IDA
    original_reference_id: PMID:18671743
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18671743
          supporting_text: Epub 2008 Jul 30. Decrease of D2 receptor binding but
            increase in D2-stimulated G-protein activation, dopamine transporter
            binding and behavioural sensitization in brains of mice treated with
            a chronic escalating dose 'binge' cocaine administration paradigm.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9016340
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9016340
          supporting_text: 'D1-like dopaminergic activation of phosphoinositide hydrolysis
            is independent of D1A dopamine receptors: evidence from D1A knockout mice.'
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:9387887
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9387887
          supporting_text: 'D1 receptors mediate dopamine action in the fetal suprachiasmatic
            nuclei: studies of mice with targeted deletion of the D1 dopamine receptor
            gene.'
  - term:
      id: GO:0006606
      label: protein import into nucleus
    evidence_type: IMP
    original_reference_id: PMID:18496528
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18496528
          supporting_text: A phosphatase cascade by which rewarding stimuli 
            control nucleosomal response.
  - term:
      id: GO:0006936
      label: muscle contraction
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:11404425
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11404425
          supporting_text: Galpha(olf) levels are regulated by receptor usage 
            and control dopamine and adenosine action in the striatum.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:9016340
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9016340
          supporting_text: 'D1-like dopaminergic activation of phosphoinositide hydrolysis
            is independent of D1A dopamine receptors: evidence from D1A knockout mice.'
  - term:
      id: GO:0007212
      label: G protein-coupled dopamine receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:16908842
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16908842
          supporting_text: Binding of internalized receptors to the PDZ domain 
            of GIPC/synectin recruits myosin VI to endocytic vesicles.
  - term:
      id: GO:0007612
      label: learning
    evidence_type: IMP
    original_reference_id: PMID:15684065
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15684065
          supporting_text: Dopamine D1 receptors involved in locomotor activity 
            and accumbens neural responses to prediction of reward associated 
            with place.
  - term:
      id: GO:0007613
      label: memory
    evidence_type: IMP
    original_reference_id: PMID:10585522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10585522
          supporting_text: Spatial learning deficit in dopamine D(1) receptor 
            knockout mice.
  - term:
      id: GO:0007625
      label: grooming behavior
    evidence_type: IMP
    original_reference_id: PMID:9749770
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9749770
          supporting_text: Action sequencing is impaired in D1A-deficient mutant
            mice.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:10222120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10222120
          supporting_text: Paradoxical locomotor behavior of dopamine D1 
            receptor transgenic mice.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:10661513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10661513
          supporting_text: Behavioral responses to cocaine and amphetamine 
            administration in mice lacking the dopamine D1 receptor.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:13679419
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:13679419
          supporting_text: Distinct roles of D1 and D5 dopamine receptors in 
            motor activity and striatal synaptic plasticity.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:15684065
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15684065
          supporting_text: Dopamine D1 receptors involved in locomotor activity 
            and accumbens neural responses to prediction of reward associated 
            with place.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:8001143
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8001143
          supporting_text: Elimination of cocaine-induced hyperactivity and 
            dopamine-mediated neurophysiological effects in dopamine D1 receptor
            mutant mice.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:9261820
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9261820
          supporting_text: Effects of repeated amphetamine treatment on the 
            locomotor activity of the dopamine D1A-deficient mouse.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IMP
    original_reference_id: PMID:9692749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9692749
          supporting_text: Behavioural assessment of mice lacking D1A dopamine 
            receptors.
  - term:
      id: GO:0008306
      label: associative learning
    evidence_type: IMP
    original_reference_id: PMID:9692749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9692749
          supporting_text: Behavioural assessment of mice lacking D1A dopamine 
            receptors.
  - term:
      id: GO:0008542
      label: visual learning
    evidence_type: IMP
    original_reference_id: PMID:10585522
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10585522
          supporting_text: Spatial learning deficit in dopamine D(1) receptor 
            knockout mice.
  - term:
      id: GO:0008542
      label: visual learning
    evidence_type: IMP
    original_reference_id: PMID:15684065
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15684065
          supporting_text: Dopamine D1 receptors involved in locomotor activity 
            and accumbens neural responses to prediction of reward associated 
            with place.
  - term:
      id: GO:0008542
      label: visual learning
    evidence_type: IMP
    original_reference_id: PMID:9692749
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9692749
          supporting_text: Behavioural assessment of mice lacking D1A dopamine 
            receptors.
  - term:
      id: GO:0014002
      label: astrocyte development
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0015872
      label: dopamine transport
    evidence_type: IMP
    original_reference_id: PMID:11404425
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11404425
          supporting_text: Galpha(olf) levels are regulated by receptor usage 
            and control dopamine and adenosine action in the striatum.
  - term:
      id: GO:0019228
      label: neuronal action potential
    evidence_type: IMP
    original_reference_id: PMID:16908842
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16908842
          supporting_text: Binding of internalized receptors to the PDZ domain 
            of GIPC/synectin recruits myosin VI to endocytic vesicles.
  - term:
      id: GO:0021542
      label: dentate gyrus development
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0021756
      label: striatum development
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0021766
      label: hippocampus development
    evidence_type: IMP
    original_reference_id: PMID:17360497
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17360497
          supporting_text: Ablation of D1 dopamine receptor-expressing cells 
            generates mice with seizures, dystonia, hyperactivity, and impaired 
            oral behavior.
  - term:
      id: GO:0035106
      label: operant conditioning
    evidence_type: IMP
    original_reference_id: PMID:12603275
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12603275
          supporting_text: Attenuation of sucrose reinforcement in dopamine D1 
            receptor deficient mice.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:10222120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10222120
          supporting_text: Paradoxical locomotor behavior of dopamine D1 
            receptor transgenic mice.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:10661513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10661513
          supporting_text: Behavioral responses to cocaine and amphetamine 
            administration in mice lacking the dopamine D1 receptor.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:12354293
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12354293
          supporting_text: The dopamine D1 receptor is a critical mediator for 
            cocaine-induced gene expression.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:16908842
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16908842
          supporting_text: Binding of internalized receptors to the PDZ domain 
            of GIPC/synectin recruits myosin VI to endocytic vesicles.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:18045908
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18045908
          supporting_text: Lack of self-administration of cocaine in dopamine D1
            receptor knock-out mice.
  - term:
      id: GO:0042220
      label: response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:9387887
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9387887
          supporting_text: 'D1 receptors mediate dopamine action in the fetal suprachiasmatic
            nuclei: studies of mice with targeted deletion of the D1 dopamine receptor
            gene.'
  - term:
      id: GO:0046960
      label: sensitization
    evidence_type: IGI
    original_reference_id: PMID:11823893
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823893
          supporting_text: 'Role of D1-like receptors in amphetamine-induced behavioral
            sensitization: a study using D1A receptor knockout mice.'
  - term:
      id: GO:0048148
      label: behavioral response to cocaine
    evidence_type: IMP
    original_reference_id: PMID:16014726
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16014726
          supporting_text: Expression of mutant NMDA receptors in dopamine D1 
            receptor-containing cells prevents cocaine sensitization and 
            decreases cocaine preference.
  - term:
      id: GO:0060291
      label: long-term synaptic potentiation
    evidence_type: IMP
    original_reference_id: PMID:13679419
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:13679419
          supporting_text: Distinct roles of D1 and D5 dopamine receptors in 
            motor activity and striatal synaptic plasticity.
  - term:
      id: GO:0060291
      label: long-term synaptic potentiation
    evidence_type: IMP
    original_reference_id: PMID:14981263
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14981263
          supporting_text: Genetic evidence for the bidirectional modulation of 
            synaptic plasticity in the prefrontal cortex by D1 receptors.
  - term:
      id: GO:0060291
      label: long-term synaptic potentiation
    evidence_type: IMP
    original_reference_id: PMID:9427321
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9427321
          supporting_text: Dopamine D1-deficient mutant mice do not express the 
            late phase of hippocampal long-term potentiation.
  - term:
      id: GO:0060292
      label: long-term synaptic depression
    evidence_type: IMP
    original_reference_id: PMID:14981263
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14981263
          supporting_text: Genetic evidence for the bidirectional modulation of 
            synaptic plasticity in the prefrontal cortex by D1 receptors.
  - term:
      id: GO:0051968
      label: positive regulation of synaptic transmission, glutamatergic
    evidence_type: IMP
    original_reference_id: PMID:8795639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8795639
          supporting_text: Modulatory actions of dopamine on NMDA 
            receptor-mediated responses are reduced in D1A-deficient mutant 
            mice.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:11069937
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11069937
          supporting_text: Dopamine D2 long receptor-deficient mice display 
            alterations in striatum-dependent functions.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IGI
    original_reference_id: PMID:11150348
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11150348
          supporting_text: 'Prepulse inhibition deficits and perseverative motor patterns
            in dopamine transporter knock-out mice: differential effects of D1 and
            D2 receptor antagonists.'
  - term:
      id: GO:0007212
      label: G protein-coupled dopamine receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:11089973
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11089973
          supporting_text: Distinct functions of the two isoforms of dopamine D2
            receptors.
  - term:
      id: GO:0042053
      label: regulation of dopamine metabolic process
    evidence_type: IMP
    original_reference_id: PMID:11438590
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11438590
          supporting_text: The role of dopamine receptors in regulating the size
            of axonal arbors.
  - term:
      id: GO:0007626
      label: locomotory behavior
    evidence_type: IGI
    original_reference_id: PMID:15272078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15272078
          supporting_text: Simultaneous absence of dopamine D1 and D2 
            receptor-mediated signaling is lethal in mice.
  - term:
      id: GO:0007631
      label: feeding behavior
    evidence_type: IGI
    original_reference_id: PMID:15272078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15272078
          supporting_text: Simultaneous absence of dopamine D1 and D2 
            receptor-mediated signaling is lethal in mice.
  - term:
      id: GO:0030432
      label: peristalsis
    evidence_type: IGI
    original_reference_id: PMID:15272078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15272078
          supporting_text: Simultaneous absence of dopamine D1 and D2 
            receptor-mediated signaling is lethal in mice.
  - term:
      id: GO:0021853
      label: cerebral cortex GABAergic interneuron migration
    evidence_type: IMP
    original_reference_id: PMID:17409246
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17409246
          supporting_text: Dopamine receptor activation modulates GABA neuron 
            migration from the basal forebrain to the cerebral cortex.
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IMP
    original_reference_id: PMID:17409246
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17409246
          supporting_text: Dopamine receptor activation modulates GABA neuron 
            migration from the basal forebrain to the cerebral cortex.
  - term:
      id: GO:0060158
      label: phospholipase C-activating dopamine receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007625
      label: grooming behavior
    evidence_type: IMP
    original_reference_id: PMID:9988094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9988094
          supporting_text: The expression of neuropeptide-induced excessive 
            grooming behavior in dopamine D1 and D2 receptor-deficient mice.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:12097513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12097513
          supporting_text: Mice lacking dopamine D2 and D3 receptors have 
            spatial working memory deficits.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:7566118
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7566118
          supporting_text: Parkinsonian-like locomotor impairment in mice 
            lacking dopamine D2 receptors.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IGI
    original_reference_id: PMID:12097513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12097513
          supporting_text: Mice lacking dopamine D2 and D3 receptors have 
            spatial working memory deficits.
  - term:
      id: GO:0007212
      label: G protein-coupled dopamine receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:12097513
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12097513
          supporting_text: Mice lacking dopamine D2 and D3 receptors have 
            spatial working memory deficits.
  - term:
      id: GO:0007628
      label: adult walking behavior
    evidence_type: IGI
    original_reference_id: PMID:12652349
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12652349
          supporting_text: Essential conservation of D1 mutant phenotype at the 
            level of individual topographies of behaviour in mice lacking both 
            D1 and D3 dopamine receptors.
  - term:
      id: GO:0007628
      label: adult walking behavior
    evidence_type: IMP
    original_reference_id: PMID:7954836
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7954836
          supporting_text: Dopamine D1 receptor mutant mice are deficient in 
            striatal expression of dynorphin and in dopamine-mediated behavioral
            responses.
  - term:
      id: GO:0007628
      label: adult walking behavior
    evidence_type: IGI
    original_reference_id: PMID:9354330
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9354330
          supporting_text: Dopamine D3 receptor mutant mice exhibit increased 
            behavioral sensitivity to concurrent stimulation of D1 and D2 
            receptors.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:16962565
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16962565
          supporting_text: 'Epub 2006 Sep 7. Low affinity binding of the classical
            D1 antagonist SCH23390 in rodent brain: potential interaction with A2A
            and D2-like receptors.'
  - term:
      id: GO:0004952
      label: dopamine neurotransmitter receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007617
      label: mating behavior
    evidence_type: IDA
    original_reference_id: PMID:9829800
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9829800
          supporting_text: Dopamine-stimulated sexual behavior is testosterone 
            dependent in mice.
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: IDA
    original_reference_id: PMID:14712229
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14712229
          supporting_text: 'G-protein-coupled receptor-mediated activation of rap
            GTPases: characterization of a novel Galphai regulated pathway.'
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:14712229
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14712229
          supporting_text: 'G-protein-coupled receptor-mediated activation of rap
            GTPases: characterization of a novel Galphai regulated pathway.'
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:12930822
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12930822
          supporting_text: 2003 Aug 20. Parkin-deficient mice exhibit 
            nigrostriatal deficits but not loss of dopaminergic neurons.
  - term:
      id: GO:0019226
      label: transmission of nerve impulse
    evidence_type: IMP
    original_reference_id: PMID:12867509
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12867509
          supporting_text: Receptor subtypes involved in the presynaptic and 
            postsynaptic actions of dopamine on striatal interneurons.
  - term:
      id: GO:0007190
      label: activation of adenylate cyclase activity
    evidence_type: IDA
    original_reference_id: PMID:12488442
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12488442
          supporting_text: Dec 17. Loss of G protein gamma 7 alters behavior and
            reduces striatal alpha(olf) level and cAMP production.
  - term:
      id: GO:0009410
      label: response to xenobiotic stimulus
    evidence_type: IDA
    original_reference_id: PMID:7549459
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7549459
          supporting_text: Role of D1/D2 dopamine and N-methyl-D-aspartate 
            (NMDA) receptors in morphine tolerance and dependence in mice.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IMP
    original_reference_id: PMID:7809078
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7809078
          supporting_text: Altered striatal function in a mutant mouse lacking 
            D1A dopamine receptors.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:7954836
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7954836
          supporting_text: Dopamine D1 receptor mutant mice are deficient in 
            striatal expression of dynorphin and in dopamine-mediated behavioral
            responses.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:8294904
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8294904
          supporting_text: Lesions of mouse striatum induced by 
            6-hydroxydopamine differentially alter the density, rate of 
            synthesis, and level of gene expression of D1 and D2 dopamine 
            receptors.
  - term:
      id: GO:0001588
      label: dopamine neurotransmitter receptor activity, coupled via Gs
    evidence_type: IDA
    original_reference_id: PMID:8738226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8738226
          supporting_text: Differences among mouse strains in the regulation by 
            mu, delta 1 and delta 2 opioid receptors of striatal adenylyl 
            cyclases activated by dopamine D1 or adenosine A2a receptors.
  - term:
      id: GO:0007191
      label: adenylate cyclase-activating dopamine receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:8738226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8738226
          supporting_text: Differences among mouse strains in the regulation by 
            mu, delta 1 and delta 2 opioid receptors of striatal adenylyl 
            cyclases activated by dopamine D1 or adenosine A2a receptors.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000008
    title: Gene Ontology annotation by the MGI curatorial staff, curated 
      orthology
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10222120
    title: Paradoxical locomotor behavior of dopamine D1 receptor transgenic 
      mice.
    findings: []
  - id: PMID:10585522
    title: Spatial learning deficit in dopamine D(1) receptor knockout mice.
    findings: []
  - id: PMID:10661513
    title: Behavioral responses to cocaine and amphetamine administration in 
      mice lacking the dopamine D1 receptor.
    findings: []
  - id: PMID:10884517
    title: Modification of dopamine D(1) receptor knockout phenotype in mice 
      lacking both dopamine D(1) and D(3) receptors.
    findings: []
  - id: PMID:11069937
    title: Dopamine D2 long receptor-deficient mice display alterations in 
      striatum-dependent functions.
    findings: []
  - id: PMID:11089973
    title: Distinct functions of the two isoforms of dopamine D2 receptors.
    findings: []
  - id: PMID:11150348
    title: 'Prepulse inhibition deficits and perseverative motor patterns in dopamine
      transporter knock-out mice: differential effects of D1 and D2 receptor antagonists.'
    findings: []
  - id: PMID:11172752
    title: Prolonged fear responses in mice lacking dopamine D1 receptor.
    findings: []
  - id: PMID:11251190
    title: Blunted brain metabolic response to ketamine in mice lacking D(1A) 
      dopamine receptors.
    findings: []
  - id: PMID:11404425
    title: Galpha(olf) levels are regulated by receptor usage and control 
      dopamine and adenosine action in the striatum.
    findings: []
  - id: PMID:11438590
    title: The role of dopamine receptors in regulating the size of axonal 
      arbors.
    findings: []
  - id: PMID:11823893
    title: 'Role of D1-like receptors in amphetamine-induced behavioral sensitization:
      a study using D1A receptor knockout mice.'
    findings: []
  - id: PMID:11923452
    title: Alpha1b-adrenergic receptors control locomotor and rewarding effects 
      of psychostimulants and opiates.
    findings: []
  - id: PMID:11985822
    title: Phenotypic resolution of spontaneous and D1-like agonist-induced 
      orofacial movement topographies in congenic dopamine D1A receptor 
      'knockout' mice.
    findings: []
  - id: PMID:12097513
    title: Mice lacking dopamine D2 and D3 receptors have spatial working memory
      deficits.
    findings: []
  - id: PMID:12223546
    title: Impaired D2 dopamine receptor function in mice lacking type 5 
      adenylyl cyclase.
    findings: []
  - id: PMID:12354293
    title: The dopamine D1 receptor is a critical mediator for cocaine-induced 
      gene expression.
    findings: []
  - id: PMID:12488442
    title: Loss of G protein gamma 7 alters behavior and reduces striatal 
      alpha(olf) level and cAMP production.
    findings: []
  - id: PMID:12603275
    title: Attenuation of sucrose reinforcement in dopamine D1 receptor 
      deficient mice.
    findings: []
  - id: PMID:12652349
    title: Essential conservation of D1 mutant phenotype at the level of 
      individual topographies of behaviour in mice lacking both D1 and D3 
      dopamine receptors.
    findings: []
  - id: PMID:12665504
    title: Motor dysfunction in type 5 adenylyl cyclase-null mice.
    findings: []
  - id: PMID:12867509
    title: Receptor subtypes involved in the presynaptic and postsynaptic 
      actions of dopamine on striatal interneurons.
    findings: []
  - id: PMID:12930822
    title: Parkin-deficient mice exhibit nigrostriatal deficits but not loss of 
      dopaminergic neurons.
    findings: []
  - id: PMID:13679419
    title: Distinct roles of D1 and D5 dopamine receptors in motor activity and 
      striatal synaptic plasticity.
    findings: []
  - id: PMID:14712229
    title: 'G-protein-coupled receptor-mediated activation of rap GTPases: characterization
      of a novel Galphai regulated pathway.'
    findings: []
  - id: PMID:14981263
    title: Genetic evidence for the bidirectional modulation of synaptic 
      plasticity in the prefrontal cortex by D1 receptors.
    findings: []
  - id: PMID:15016423
    title: Enhancement of dopamine-induced signaling responses in the forebrain 
      of mice lacking dopamine D3 receptor.
    findings: []
  - id: PMID:15272078
    title: Simultaneous absence of dopamine D1 and D2 receptor-mediated 
      signaling is lethal in mice.
    findings: []
  - id: PMID:15684065
    title: Dopamine D1 receptors involved in locomotor activity and accumbens 
      neural responses to prediction of reward associated with place.
    findings: []
  - id: PMID:15932618
    title: Mice lacking dopamine D1 receptors express normal lithium 
      chloride-induced conditioned taste aversion for salt but not sucrose.
    findings: []
  - id: PMID:16014726
    title: Expression of mutant NMDA receptors in dopamine D1 
      receptor-containing cells prevents cocaine sensitization and decreases 
      cocaine preference.
    findings: []
  - id: PMID:16908842
    title: Binding of internalized receptors to the PDZ domain of GIPC/synectin 
      recruits myosin VI to endocytic vesicles.
    findings: []
  - id: PMID:16962565
    title: 'Low affinity binding of the classical D1 antagonist SCH23390 in rodent
      brain: potential interaction with A2A and D2-like receptors.'
    findings: []
  - id: PMID:17194762
    title: D1-D2 dopamine receptor heterooligomers with unique pharmacology are 
      coupled to rapid activation of Gq/11 in the striatum.
    findings: []
  - id: PMID:17360497
    title: Ablation of D1 dopamine receptor-expressing cells generates mice with
      seizures, dystonia, hyperactivity, and impaired oral behavior.
    findings: []
  - id: PMID:17409246
    title: Dopamine receptor activation modulates GABA neuron migration from the
      basal forebrain to the cerebral cortex.
    findings: []
  - id: PMID:18045908
    title: Lack of self-administration of cocaine in dopamine D1 receptor 
      knock-out mice.
    findings: []
  - id: PMID:18486343
    title: 'Hyperthermic and lethal effects of methamphetamine: roles of dopamine
      D1 and D2 receptors.'
    findings: []
  - id: PMID:18496528
    title: A phosphatase cascade by which rewarding stimuli control nucleosomal 
      response.
    findings: []
  - id: PMID:18671743
    title: Decrease of D2 receptor binding but increase in D2-stimulated 
      G-protein activation, dopamine transporter binding and behavioural 
      sensitization in brains of mice treated with a chronic escalating dose 
      'binge' cocaine administration paradigm.
    findings: []
  - id: PMID:21368124
    title: Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and 
      D2R-expressing medium spiny neurons is required for amphetamine 
      sensitization.
    findings: []
  - id: PMID:22586226
    title: Regulation of prefrontal excitatory neurotransmission by dopamine in 
      the nucleus accumbens core.
    findings: []
  - id: PMID:23842570
    title: Prostaglandin E receptor EP1 forms a complex with dopamine D1 
      receptor and directs D1-induced cAMP production to adenylyl cyclase 7 
      through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.
    findings: []
  - id: PMID:24550737
    title: Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine 
      signaling in striatal D1 neurons.
    findings: []
  - id: PMID:25258080
    title: A critical time window for dopamine actions on the structural 
      plasticity of dendritic spines.
    findings: []
  - id: PMID:25865831
    title: Drebrin depletion alters neurotransmitter receptor levels in protein 
      complexes, dendritic spine morphogenesis and memory-related synaptic 
      plasticity in the mouse hippocampus.
    findings: []
  - id: PMID:26053317
    title: Identification of G Protein-Coupled Receptors (GPCRs) in Primary 
      Cilia and Their Possible Involvement in Body Weight Control.
    findings: []
  - id: PMID:27035941
    title: Dopamine synapse is a neuroligin-2-mediated contact between 
      dopaminergic presynaptic and GABAergic postsynaptic structures.
    findings: []
  - id: PMID:27460146
    title: VPS35 regulates cell surface recycling and signaling of dopamine 
      receptor D1.
    findings: []
  - id: PMID:28154160
    title: Tubby family proteins are adapters for ciliary trafficking of 
      integral membrane proteins.
    findings: []
  - id: PMID:7549459
    title: Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in 
      morphine tolerance and dependence in mice.
    findings: []
  - id: PMID:7566118
    title: Parkinsonian-like locomotor impairment in mice lacking dopamine D2 
      receptors.
    findings: []
  - id: PMID:7809078
    title: Altered striatal function in a mutant mouse lacking D1A dopamine 
      receptors.
    findings: []
  - id: PMID:7954836
    title: Dopamine D1 receptor mutant mice are deficient in striatal expression
      of dynorphin and in dopamine-mediated behavioral responses.
    findings: []
  - id: PMID:8001143
    title: Elimination of cocaine-induced hyperactivity and dopamine-mediated 
      neurophysiological effects in dopamine D1 receptor mutant mice.
    findings: []
  - id: PMID:8294904
    title: Lesions of mouse striatum induced by 6-hydroxydopamine differentially
      alter the density, rate of synthesis, and level of gene expression of D1 
      and D2 dopamine receptors.
    findings: []
  - id: PMID:8738226
    title: Differences among mouse strains in the regulation by mu, delta 1 and 
      delta 2 opioid receptors of striatal adenylyl cyclases activated by 
      dopamine D1 or adenosine A2a receptors.
    findings: []
  - id: PMID:8795639
    title: Modulatory actions of dopamine on NMDA receptor-mediated responses 
      are reduced in D1A-deficient mutant mice.
    findings: []
  - id: PMID:9016340
    title: 'D1-like dopaminergic activation of phosphoinositide hydrolysis is independent
      of D1A dopamine receptors: evidence from D1A knockout mice.'
    findings: []
  - id: PMID:9261820
    title: Effects of repeated amphetamine treatment on the locomotor activity 
      of the dopamine D1A-deficient mouse.
    findings: []
  - id: PMID:9354330
    title: Dopamine D3 receptor mutant mice exhibit increased behavioral 
      sensitivity to concurrent stimulation of D1 and D2 receptors.
    findings: []
  - id: PMID:9387887
    title: 'D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei:
      studies of mice with targeted deletion of the D1 dopamine receptor gene.'
    findings: []
  - id: PMID:9427321
    title: Dopamine D1-deficient mutant mice do not express the late phase of 
      hippocampal long-term potentiation.
    findings: []
  - id: PMID:9692749
    title: Behavioural assessment of mice lacking D1A dopamine receptors.
    findings: []
  - id: PMID:9749770
    title: Action sequencing is impaired in D1A-deficient mutant mice.
    findings: []
  - id: PMID:9829800
    title: Dopamine-stimulated sexual behavior is testosterone dependent in 
      mice.
    findings: []
  - id: PMID:9988094
    title: The expression of neuropeptide-induced excessive grooming behavior in
      dopamine D1 and D2 receptor-deficient mice.
    findings: []