Dopamine D1 receptor (Drd1, D1A) is a class A seven-transmembrane dopamine receptor. Its core molecular role is dopamine binding and G protein-coupled receptor signaling, predominantly through Gs/Golf-mediated stimulation of adenylyl cyclase and cAMP production at neuronal plasma and synaptic membranes. Reported D1-D2 receptor heteromers and ciliary localization add specialized signaling and trafficking contexts. Much of what is known about mouse Drd1 comes from knockout, drug-response and neuronal circuit studies, which report downstream physiological and behavioural consequences rather than the receptor's direct signalling activity.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004930 G protein-coupled receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons. |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: positive regulation of MAPK cascade is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway | IBA GO_REF:0000033 | MODIFY | Summary: The source evidence concerns D1-like dopamine receptor activation of adenylyl cyclase, but the adrenergic receptor pathway term is the wrong biological specificity for Drd1. Reason: Drd1 is a dopamine receptor, not an adrenergic receptor. The dopamine-specific adenylyl cyclase pathway term captures the same signaling mechanism without cross-transmitter overreach. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: WRONG ORTHOLOG OR PARALOG Sources checked: PANTHER:PTN001205212 SUPPORTS SOURCE BUT NOT TARGET Node in PTHR24248, whose PANTHER family name is "ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR". The target is in that same family but in a different subfamily - UniProt assigns mouse Drd1 to PTHR24248:SF139 "D(1A) DOPAMINE RECEPTOR" - and every seed of this node is a beta-adrenergic receptor. The Gs/adenylyl-cyclase mechanism transfers across the subfamilies; the ligand qualifier carried by GO:0071880 does not. MGI:MGI:87938 · mouse Adrb2 (adrenergic receptor, beta 2) SUPPORTS SOURCE BUT NOT TARGET A genuine beta-adrenergic receptor, for which the adrenergic-qualified pathway term is correct; it is the transmitter qualifier that does not survive transfer to a dopamine receptor. MGI:MGI:87939 · mouse Adrb3 (adrenergic receptor, beta 3) SUPPORTS SOURCE BUT NOT TARGET Same beta-adrenergic subfamily as Adrb2; correct at the source, wrong ligand for the target. RGD:2061 · rat Adrb3 (adrenoceptor beta 3) SUPPORTS SOURCE BUT NOT TARGET Rat ortholog of the Adrb3 seed; adds phylogenetic depth to the beta-adrenergic clade, not to Drd1. UniProtKB:P07550 · human ADRB2 (Beta-2 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed; supports the adrenergic-qualified term at its own subfamily only. UniProtKB:P08588 · human ADRB1 (Beta-1 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed; supports the adrenergic-qualified term at its own subfamily only. UniProtKB:P13945 · human ADRB3 (Beta-3 adrenergic receptor) SUPPORTS SOURCE BUT NOT TARGET Human beta-adrenergic seed. Note that GO:0007191 is not a child of GO:0071880 - both are children of GO:0007189 (adenylate cyclase-activating GPCR signaling pathway) - so the proposed replacement is a same-level re-scope onto the correct transmitter, not a narrowing of a parent. Proposed replacements: adenylate cyclase-activating dopamine receptor signaling pathway |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IBA GO_REF:0000033 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. file:mouse/Drd1/Drd1-deep-research-falcon.md Falcon synthesis supports Drd1 as a D1-like class A GPCR that couples dopamine binding to Gs/Golf-mediated adenylyl cyclase and cAMP/PKA signaling. |
| GO:0001975 response to amphetamine | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0004930 G protein-coupled receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0004952 dopamine neurotransmitter receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005789 endoplasmic reticulum membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: endoplasmic reticulum membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0007165 signal transduction | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: signal transduction is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0007186 G protein-coupled receptor signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0008306 associative learning | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0016020 membrane | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0030425 dendrite | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0042220 response to cocaine | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042311 vasodilation | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: vasodilation is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0043197 dendritic spine | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0046960 sensitization | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0060170 ciliary membrane | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0060292 long-term synaptic depression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0120025 plasma membrane bounded cell projection | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: plasma membrane bounded cell projection is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | ISO GO_REF:0000119 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | ISO GO_REF:0000119 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | ISO GO_REF:0000119 | ACCEPT | Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: adenylate cyclase-activating G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | ISO GO_REF:0000119 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0032795 heterotrimeric G-protein binding | ISO GO_REF:0000119 | ACCEPT | Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0035240 dopamine binding | ISO GO_REF:0000119 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0051281 positive regulation of release of sequestered calcium ion into cytosol | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060170 ciliary membrane | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: ciliary membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0071870 cellular response to catecholamine stimulus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0097648 G protein-coupled receptor complex | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0097730 non-motile cilium | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:1990763 arrestin family protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IEA GO_REF:0000120 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | IEA GO_REF:0000107 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005929 cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | IEA GO_REF:0000107 | ACCEPT | Summary: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0032795 heterotrimeric G-protein binding | IEA GO_REF:0000107 | ACCEPT | Summary: heterotrimeric G-protein binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0035240 dopamine binding | IEA GO_REF:0000107 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0051281 positive regulation of release of sequestered calcium ion into cytosol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of release of sequestered calcium ion into cytosol is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0071870 cellular response to catecholamine stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to catecholamine stimulus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0097648 G protein-coupled receptor complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: G protein-coupled receptor complex is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0097730 non-motile cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:1990763 arrestin family protein binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: arrestin family protein binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0097731 9+0 non-motile cilium | IDA PMID:26053317 Identification of G Protein-Coupled Receptors (GPCRs) in Pri... | KEEP AS NON CORE | Summary: 9+0 non-motile cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0001934 positive regulation of protein phosphorylation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006469 negative regulation of protein kinase activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of protein kinase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | ISO GO_REF:0000096 | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001965 G-protein alpha-subunit binding | ISO GO_REF:0000096 | ACCEPT | Summary: G-protein alpha-subunit binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0004930 G protein-coupled receptor activity | ISO GO_REF:0000096 | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0005102 signaling receptor binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: signaling receptor binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005886 plasma membrane | ISO GO_REF:0000096 | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. |
| GO:0005901 caveola | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: caveola is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0006886 intracellular protein transport | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: intracellular protein transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | ISO GO_REF:0000096 | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007625 grooming behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008306 associative learning | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0009986 cell surface | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cell surface is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0019229 regulation of vasoconstriction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of vasoconstriction is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0019722 calcium-mediated signaling | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: calcium-mediated signaling is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0019903 protein phosphatase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: protein phosphatase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0030336 negative regulation of cell migration | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0030424 axon | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0030425 dendrite | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendrite is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0031701 angiotensin receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: angiotensin receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0031750 D3 dopamine receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: D3 dopamine receptor binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0035106 operant conditioning | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035176 social behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: social behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035240 dopamine binding | ISO GO_REF:0000096 | ACCEPT | Summary: dopamine binding is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0042321 negative regulation of circadian sleep/wake cycle, sleep | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of circadian sleep/wake cycle, sleep is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042734 presynaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0042755 eating behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: eating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0043025 neuronal cell body | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neuronal cell body is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043197 dendritic spine | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043198 dendritic shaft | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic shaft is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0043269 regulation of monoatomic ion transport | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of monoatomic ion transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0043679 axon terminus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: axon terminus is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044326 dendritic spine neck | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine neck is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044327 dendritic spine head | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine head is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0044877 protein-containing complex binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: protein-containing complex binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0045211 postsynaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0045838 positive regulation of membrane potential | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of membrane potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0048148 behavioral response to cocaine | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0050805 negative regulation of synaptic transmission | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0051117 ATPase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ATPase binding captures a reported receptor complex or regulatory interaction rather than the core dopamine receptor activity. Reason: The interaction may be biologically relevant for receptor trafficking, desensitization, or heteromer-specific signaling, but it is not the main Drd1 molecular function. |
| GO:0098978 glutamatergic synapse | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0099170 postsynaptic modulation of chemical synaptic transmission | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1900038 negative regulation of cellular response to hypoxia | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cellular response to hypoxia is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1900273 positive regulation of long-term synaptic potentiation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of long-term synaptic potentiation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:1901363 heterocyclic compound binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: heterocyclic compound binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:2000253 positive regulation of feeding behavior | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042734 presynaptic membrane | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: presynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0045211 postsynaptic membrane | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: postsynaptic membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | IDA PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | EXP PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098978 glutamatergic synapse | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: glutamatergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0098982 GABA-ergic synapse | IDA PMID:27035941 Dopamine synapse is a neuroligin-2-mediated contact between ... | KEEP AS NON CORE | Summary: GABA-ergic synapse is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0099010 modification of postsynaptic structure | IDA PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099010 modification of postsynaptic structure | EXP PMID:25258080 A critical time window for dopamine actions on the structura... | KEEP AS NON CORE | Summary: modification of postsynaptic structure is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | IDA PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | EXP PMID:22586226 Regulation of prefrontal excitatory neurotransmission by dop... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007626 locomotory behavior | IGI PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:10884517 Modification of dopamine D(1) receptor knockout phenotype in... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:11923452 Alpha1b-adrenergic receptors control locomotor and rewarding... | UNDECIDED | Summary: PMID:11923452 is an alpha1b-adrenergic receptor knockout study and uses D1 agonist response to assess compensation, not to directly test Drd1 adenylyl cyclase signaling. Reason: The term matches canonical Drd1 pathway biology, but this specific PMID is indirect and non-Drd1-centric, so the annotation should not be accepted from this evidence. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IGI PMID:12223546 Impaired D2 dopamine receptor function in mice lacking type ... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:12665504 Motor dysfunction in type 5 adenylyl cyclase-null mice. | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco... | MODIFY | Summary: PMID:17194762 supports D1-D2 heteromer signaling through Gq/11 and intracellular calcium release, not adenylyl-cyclase activation. Reason: The original term has the correct dopamine receptor signaling context but the wrong second messenger specificity for this PMID; use the phospholipase C/calcium dopamine receptor pathway already represented by the companion annotation. Proposed replacements: phospholipase C-activating dopamine receptor signaling pathway |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IDA PMID:15016423 Enhancement of dopamine-induced signaling responses in the f... | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | IGI PMID:17194762 D1-D2 dopamine receptor heterooligomers with unique pharmaco... | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0005929 cilium | ISO PMID:28154160 Tubby family proteins are adapters for ciliary trafficking o... | KEEP AS NON CORE | Summary: cilium is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005515 protein binding | IPI PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0043197 dendritic spine | IDA PMID:25865831 Drebrin depletion alters neurotransmitter receptor levels in... | KEEP AS NON CORE | Summary: dendritic spine is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0005515 protein binding | IPI PMID:23842570 Prostaglandin E receptor EP1 forms a complex with dopamine D... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0001932 regulation of protein phosphorylation | IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: regulation of protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006468 protein phosphorylation | IDA PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: protein phosphorylation is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006606 protein import into nucleus | EXP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0005515 protein binding | IPI PMID:27460146 VPS35 regulates cell surface recycling and signaling of dopa... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005515 protein binding | IPI PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005783 endoplasmic reticulum | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | KEEP AS NON CORE | Summary: endoplasmic reticulum is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0005886 plasma membrane | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | ACCEPT | Summary: plasma membrane is the principal cell-surface location where Drd1 carries out dopamine receptor signaling. Reason: Drd1 is a multi-pass GPCR whose canonical dopamine/G protein signaling occurs at the plasma membrane. Supporting Evidence: PMID:24550737 Plasma membrane D1R and its signaling are reduced in ros striatonigral neurons. |
| GO:0012505 endomembrane system | IDA PMID:24550737 Mutation of SLC35D3 causes metabolic syndrome by impairing d... | KEEP AS NON CORE | Summary: endomembrane system is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0007626 locomotory behavior | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042711 maternal behavior | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042711 maternal behavior | IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | KEEP AS NON CORE | Summary: maternal behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0046959 habituation | IMP PMID:11985822 Phenotypic resolution of spontaneous and D1-like agonist-ind... | KEEP AS NON CORE | Summary: habituation is retained as a non-core annotation pending more granular review of the original evidence. Reason: The term is not the primary receptor activity, but the existing evidence does not justify removal. |
| GO:0001975 response to amphetamine | IGI PMID:21368124 Balanced NMDA receptor activity in dopamine D1 receptor (D1R... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0016020 membrane | IDA PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0016020 membrane | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0016020 membrane | IDA PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | KEEP AS NON CORE | Summary: membrane is supported as a localization or trafficking context for D1 receptor, but it is secondary to the receptor signaling function. Reason: Drd1 is a multi-pass membrane receptor with neuronal, synaptic, ER/endomembrane trafficking, and ciliary localization evidence. These locations explain where signaling occurs but do not by themselves define the core molecular activity. |
| GO:0009410 response to xenobiotic stimulus | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0098708 D-glucose import across plasma membrane | IMP PMID:11251190 Blunted brain metabolic response to ketamine in mice lacking... | KEEP AS NON CORE | Summary: D-glucose import across plasma membrane is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001659 temperature homeostasis | IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of... | KEEP AS NON CORE | Summary: temperature homeostasis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001661 conditioned taste aversion | IMP PMID:15932618 Mice lacking dopamine D1 receptors express normal lithium ch... | KEEP AS NON CORE | Summary: conditioned taste aversion is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001662 behavioral fear response | IMP PMID:11172752 Prolonged fear responses in mice lacking dopamine D1 recepto... | KEEP AS NON CORE | Summary: behavioral fear response is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001963 synaptic transmission, dopaminergic | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: synaptic transmission, dopaminergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001975 response to amphetamine | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:18486343 Hyperthermic and lethal effects of methamphetamine: roles of... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0001975 response to amphetamine | IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0004952 dopamine neurotransmitter receptor activity | IDA PMID:18671743 Decrease of D2 receptor binding but increase in D2-stimulate... | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0005515 protein binding | IPI PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | MARK AS OVER ANNOTATED | Summary: protein binding is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0005634 nucleus | IDA PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | MARK AS OVER ANNOTATED | Summary: nucleus is not wrong as a broad or downstream association, but it is not an informative primary annotation for Drd1. Reason: The annotation either uses an overly generic binding/signaling term, a computationally inferred phenotype, or a downstream physiological outcome. The receptor-specific dopamine/Gs/cAMP annotations capture the gene product function more cleanly. |
| GO:0006606 protein import into nucleus | IMP PMID:18496528 A phosphatase cascade by which rewarding stimuli control nuc... | KEEP AS NON CORE | Summary: protein import into nucleus is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0006936 muscle contraction | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: muscle contraction is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007186 G protein-coupled receptor signaling pathway | IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr... | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IMP PMID:9016340 D1-like dopaminergic activation of phosphoinositide hydrolys... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007612 learning | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007613 memory | IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ... | KEEP AS NON CORE | Summary: memory is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007625 grooming behavior | IMP PMID:9749770 Action sequencing is impaired in D1A-deficient mutant mice. | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:8001143 Elimination of cocaine-induced hyperactivity and dopamine-me... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:9261820 Effects of repeated amphetamine treatment on the locomotor a... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007626 locomotory behavior | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008306 associative learning | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: associative learning is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0008542 visual learning | IMP PMID:10585522 Spatial learning deficit in dopamine D(1) receptor knockout ... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:15684065 Dopamine D1 receptors involved in locomotor activity and acc... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0008542 visual learning | IMP PMID:9692749 Behavioural assessment of mice lacking D1A dopamine receptor... | KEEP AS NON CORE | Summary: visual learning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0014002 astrocyte development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: astrocyte development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0015872 dopamine transport | IMP PMID:11404425 Galpha(olf) levels are regulated by receptor usage and contr... | KEEP AS NON CORE | Summary: dopamine transport is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0019228 neuronal action potential | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: neuronal action potential is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0021542 dentate gyrus development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: dentate gyrus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021756 striatum development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: striatum development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021766 hippocampus development | IMP PMID:17360497 Ablation of D1 dopamine receptor-expressing cells generates ... | KEEP AS NON CORE | Summary: hippocampus development is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0035106 operant conditioning | IMP PMID:12603275 Attenuation of sucrose reinforcement in dopamine D1 receptor... | KEEP AS NON CORE | Summary: operant conditioning is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0042220 response to cocaine | IMP PMID:10222120 Paradoxical locomotor behavior of dopamine D1 receptor trans... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:10661513 Behavioral responses to cocaine and amphetamine administrati... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:12354293 The dopamine D1 receptor is a critical mediator for cocaine-... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:16908842 Binding of internalized receptors to the PDZ domain of GIPC/... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:18045908 Lack of self-administration of cocaine in dopamine D1 recept... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0042220 response to cocaine | IMP PMID:9387887 D1 receptors mediate dopamine action in the fetal suprachias... | KEEP AS NON CORE | Summary: response to cocaine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0046960 sensitization | IGI PMID:11823893 Role of D1-like receptors in amphetamine-induced behavioral ... | KEEP AS NON CORE | Summary: sensitization is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0048148 behavioral response to cocaine | IMP PMID:16014726 Expression of mutant NMDA receptors in dopamine D1 receptor-... | KEEP AS NON CORE | Summary: behavioral response to cocaine is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:13679419 Distinct roles of D1 and D5 dopamine receptors in motor acti... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:9427321 Dopamine D1-deficient mutant mice do not express the late ph... | KEEP AS NON CORE | Summary: long-term synaptic potentiation is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0060292 long-term synaptic depression | IMP PMID:14981263 Genetic evidence for the bidirectional modulation of synapti... | KEEP AS NON CORE | Summary: long-term synaptic depression is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0051968 positive regulation of synaptic transmission, glutamatergic | IMP PMID:8795639 Modulatory actions of dopamine on NMDA receptor-mediated res... | KEEP AS NON CORE | Summary: positive regulation of synaptic transmission, glutamatergic is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:11069937 Dopamine D2 long receptor-deficient mice display alterations... | UNDECIDED | Summary: PMID:11069937 is a D2L receptor-deficient mouse study and does not directly test Drd1 Gs-coupled receptor activity. Reason: The term matches Drd1 core molecular function, but this specific evidence is indirect and D2-centric, so the annotation should not be accepted from this PMID without direct Drd1 support. |
| GO:0007626 locomotory behavior | IGI PMID:11150348 Prepulse inhibition deficits and perseverative motor pattern... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IGI PMID:11089973 Distinct functions of the two isoforms of dopamine D2 recept... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0042053 regulation of dopamine metabolic process | IMP PMID:11438590 The role of dopamine receptors in regulating the size of axo... | KEEP AS NON CORE | Summary: regulation of dopamine metabolic process is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007626 locomotory behavior | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: locomotory behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007631 feeding behavior | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: feeding behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0030432 peristalsis | IGI PMID:15272078 Simultaneous absence of dopamine D1 and D2 receptor-mediated... | KEEP AS NON CORE | Summary: peristalsis is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0021853 cerebral cortex GABAergic interneuron migration | IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration... | KEEP AS NON CORE | Summary: cerebral cortex GABAergic interneuron migration is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0030335 positive regulation of cell migration | IMP PMID:17409246 Dopamine receptor activation modulates GABA neuron migration... | KEEP AS NON CORE | Summary: positive regulation of cell migration is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0060158 phospholipase C-activating dopamine receptor signaling pathway | ISO GO_REF:0000008 | KEEP AS NON CORE | Summary: phospholipase C-activating dopamine receptor signaling pathway is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007625 grooming behavior | IMP PMID:9988094 The expression of neuropeptide-induced excessive grooming be... | KEEP AS NON CORE | Summary: grooming behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | UNDECIDED | Summary: PMID:12097513 examines D2/D3 mutant responses to D1 agonist challenge and working-memory rescue, but the cached abstract does not directly demonstrate Drd1 Gs-coupled receptor activity. Reason: Direct Drd1 molecular-function support would require full-text confirmation; the available abstract supports indirect D1-mediated physiological context rather than direct Gs coupling. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:7566118 Parkinsonian-like locomotor impairment in mice lacking dopam... | UNDECIDED | Summary: PMID:7566118 is a D2 receptor knockout study and does not provide direct cached support for Drd1 Gs-coupled molecular activity. Reason: The accessible abstract supports dopaminergic-system physiology centered on D2 receptor deficiency, not direct Drd1 receptor activity; full-text evidence would be needed. |
| GO:0001975 response to amphetamine | IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | KEEP AS NON CORE | Summary: response to amphetamine is a downstream behavioral, pharmacological, or synaptic-plasticity outcome of altered D1 receptor signaling. Reason: The term is supported by mouse genetic, pharmacology, or orthology-based evidence, but it represents a neural-circuit or organismal consequence rather than Drd1 core molecular function. |
| GO:0007212 G protein-coupled dopamine receptor signaling pathway | IGI PMID:12097513 Mice lacking dopamine D2 and D3 receptors have spatial worki... | ACCEPT | Summary: G protein-coupled dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0007628 adult walking behavior | IGI PMID:12652349 Essential conservation of D1 mutant phenotype at the level o... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007628 adult walking behavior | IMP PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0007628 adult walking behavior | IGI PMID:9354330 Dopamine D3 receptor mutant mice exhibit increased behaviora... | KEEP AS NON CORE | Summary: adult walking behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:16962565 Low affinity binding of the classical D1 antagonist SCH23390... | UNDECIDED | Summary: PMID:16962565 analyzes SCH23390 binding states and D2/A2A receptor involvement; the cached abstract does not directly establish Drd1 Gs-coupled receptor activity. Reason: The abstract distinguishes binding components including sites independent of D1 expression, so direct Drd1 molecular-function support requires full-text confirmation. |
| GO:0004952 dopamine neurotransmitter receptor activity | ISO GO_REF:0000008 | ACCEPT | Summary: dopamine neurotransmitter receptor activity is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. |
| GO:0007617 mating behavior | IDA PMID:9829800 Dopamine-stimulated sexual behavior is testosterone dependen... | KEEP AS NON CORE | Summary: mating behavior is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0004930 G protein-coupled receptor activity | IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase... | ACCEPT | Summary: G protein-coupled receptor activity is a correct parent-level molecular function for Drd1, though the dopamine- and Gs-coupled terms are more informative. Reason: Drd1 is a rhodopsin-family GPCR; the parent term is accurate but not the most specific representation. |
| GO:0007186 G protein-coupled receptor signaling pathway | IDA PMID:14712229 G-protein-coupled receptor-mediated activation of rap GTPase... | ACCEPT | Summary: G protein-coupled receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:12930822 Parkin-deficient mice exhibit nigrostriatal deficits but not... | UNDECIDED | Summary: PMID:12930822 reports parkin-deficient mouse nigrostriatal phenotypes and dopamine regulation; the cached abstract does not directly support Drd1 Gs-coupled molecular activity. Reason: The available evidence is indirect dopaminergic-system context; full-text confirmation would be needed before accepting this as a Drd1 molecular-function annotation. |
| GO:0019226 transmission of nerve impulse | IMP PMID:12867509 Receptor subtypes involved in the presynaptic and postsynapt... | KEEP AS NON CORE | Summary: transmission of nerve impulse is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0007190 activation of adenylate cyclase activity | IDA PMID:12488442 Loss of G protein gamma 7 alters behavior and reduces striat... | KEEP AS NON CORE | Summary: activation of adenylate cyclase activity is a downstream or specialized signaling consequence of D1 receptor activity. Reason: This term is consistent with experimental or orthology-supported literature, especially synaptic, cAMP/MAPK, calcium, or receptor trafficking contexts, but it should not be treated as the core function in place of dopamine receptor/G protein coupling. |
| GO:0009410 response to xenobiotic stimulus | IDA PMID:7549459 Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) recep... | KEEP AS NON CORE | Summary: response to xenobiotic stimulus is a mouse phenotype or circuit-level outcome of altered D1 receptor signaling. Reason: Knockout and pharmacology studies support roles in locomotion, learning, drug responses, development, and synaptic plasticity, but these are downstream organismal or neural-circuit consequences rather than the gene product core function. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IMP PMID:7809078 Altered striatal function in a mutant mouse lacking D1A dopa... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:7954836 Dopamine D1 receptor mutant mice are deficient in striatal e... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:8294904 Lesions of mouse striatum induced by 6-hydroxydopamine diffe... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | ACCEPT | Summary: dopamine neurotransmitter receptor activity, coupled via Gs is part of the core Drd1 molecular function: dopamine recognition and coupling to heterotrimeric G proteins, especially Gs/Golf, to initiate cAMP signaling. Reason: This directly describes receptor ligand recognition or proximal G protein coupling rather than a downstream behavioral phenotype. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway | IDA PMID:8738226 Differences among mouse strains in the regulation by mu, del... | ACCEPT | Summary: adenylate cyclase-activating dopamine receptor signaling pathway represents the canonical D1 receptor signaling pathway downstream of dopamine binding and Gs/Golf activation. Reason: Adenylyl cyclase/cAMP signaling is the primary curated pathway for D1-like dopamine receptors; broader GPCR signaling parents are correct but less specific. Supporting Evidence: UniProtKB:Q61616 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
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Download this section (compressed HTML)Q: Which Drd1 annotations from whole-animal knockout or drug-response studies should remain GO biological process annotations versus be treated only as mouse phenotype evidence?
Q: Should D1-D2 heteromer-specific PLC/calcium signaling be annotated to Drd1 generally, or only in contexts where heteromer formation is directly demonstrated?
Q: Which neuronal compartments have endogenous Drd1 protein evidence in mouse rather than overexpression or orthology-transfer evidence?
Experiment: Measure endogenous Drd1 localization and signaling at plasma membrane, dendritic spine, and ciliary compartments using tagged knock-in Drd1 mice.
Hypothesis: Some specialized ciliary and synaptic annotations reflect context-specific receptor pools rather than general Drd1 localization.
Type: Endogenous tagging with quantitative imaging and cAMP biosensors
Experiment: Separate Gs/Golf and D1-D2 heteromer signaling with receptor mutants or cell-type-specific rescue in striatal medium spiny neurons.
Hypothesis: Canonical Drd1 signaling is Gs/Golf-cAMP mediated, while PLC/calcium terms require heteromer-specific context.
Type: Cell-type-specific genetic rescue and second-messenger assays
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