Edn1

id: P22387
gene_symbol: Edn1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Edn1'
existing_annotations:
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045987
      label: positive regulation of smooth muscle contraction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003100
      label: regulation of systemic arterial blood pressure by endothelin
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014826
      label: vein smooth muscle contraction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031707
      label: endothelin A receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031708
      label: endothelin B receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019229
      label: regulation of vasoconstriction
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097746
      label: blood vessel diameter maintenance
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001821
      label: histamine secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003100
      label: regulation of systemic arterial blood pressure by endothelin
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005125
      label: cytokine activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007204
      label: positive regulation of cytosolic calcium ion concentration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007267
      label: cell-cell signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009410
      label: response to xenobiotic stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010193
      label: response to ozone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010460
      label: positive regulation of heart rate
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010613
      label: positive regulation of cardiac muscle hypertrophy
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014823
      label: response to activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014824
      label: artery smooth muscle contraction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014826
      label: vein smooth muscle contraction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019722
      label: calcium-mediated signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0023019
      label: signal transduction involved in regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030072
      label: peptide hormone secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030185
      label: nitric oxide transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031707
      label: endothelin A receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031708
      label: endothelin B receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032308
      label: positive regulation of prostaglandin secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032496
      label: response to lipopolysaccharide
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033093
      label: Weibel-Palade body
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033574
      label: response to testosterone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034392
      label: negative regulation of smooth muscle cell apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034696
      label: response to prostaglandin F
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035094
      label: response to nicotine
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035556
      label: intracellular signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035994
      label: response to muscle stretch
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042045
      label: epithelial fluid transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042482
      label: positive regulation of odontogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042554
      label: superoxide anion generation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043200
      label: response to amino acid
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044321
      label: response to leptin
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045178
      label: basal part of cell
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045793
      label: positive regulation of cell size
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045987
      label: positive regulation of smooth muscle contraction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046330
      label: positive regulation of JNK cascade
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046887
      label: positive regulation of hormone secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046888
      label: negative regulation of hormone secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048237
      label: rough endoplasmic reticulum lumen
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050850
      label: positive regulation of calcium-mediated signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051248
      label: negative regulation of protein metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051899
      label: membrane depolarization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060137
      label: maternal process involved in parturition
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060298
      label: positive regulation of sarcomere organization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061051
      label: positive regulation of cell growth involved in cardiac muscle cell 
        development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070301
      label: cellular response to hydrogen peroxide
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071277
      label: cellular response to calcium ion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071346
      label: cellular response to type II interferon
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071347
      label: cellular response to interleukin-1
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071356
      label: cellular response to tumor necrosis factor
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071375
      label: cellular response to peptide hormone stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071385
      label: cellular response to glucocorticoid stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071389
      label: cellular response to mineralocorticoid stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071398
      label: cellular response to fatty acid
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071456
      label: cellular response to hypoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071548
      label: response to dexamethasone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071559
      label: response to transforming growth factor beta
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071560
      label: cellular response to transforming growth factor beta stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090023
      label: positive regulation of neutrophil chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0141156
      label: cAMP/PKA signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0160195
      label: negative regulation of phospholipase C/protein kinase C signal 
        transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1901224
      label: positive regulation of non-canonical NF-kappaB signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902074
      label: response to salt
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell 
        proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003100
      label: regulation of systemic arterial blood pressure by endothelin
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005125
      label: cytokine activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007267
      label: cell-cell signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010460
      label: positive regulation of heart rate
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010613
      label: positive regulation of cardiac muscle hypertrophy
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014824
      label: artery smooth muscle contraction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014826
      label: vein smooth muscle contraction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019722
      label: calcium-mediated signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0023019
      label: signal transduction involved in regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030072
      label: peptide hormone secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030185
      label: nitric oxide transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031394
      label: positive regulation of prostaglandin biosynthetic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031707
      label: endothelin A receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031708
      label: endothelin B receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043491
      label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045793
      label: positive regulation of cell size
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046330
      label: positive regulation of JNK cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046887
      label: positive regulation of hormone secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048661
      label: positive regulation of smooth muscle cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050850
      label: positive regulation of calcium-mediated signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051248
      label: negative regulation of protein metabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060298
      label: positive regulation of sarcomere organization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061051
      label: positive regulation of cell growth involved in cardiac muscle cell 
        development
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070101
      label: positive regulation of chemokine-mediated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0160195
      label: negative regulation of phospholipase C/protein kinase C signal 
        transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001821
      label: histamine secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007204
      label: positive regulation of cytosolic calcium ion concentration
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010629
      label: negative regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014824
      label: artery smooth muscle contraction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031707
      label: endothelin A receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031708
      label: endothelin B receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032308
      label: positive regulation of prostaglandin secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033093
      label: Weibel-Palade body
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034392
      label: negative regulation of smooth muscle cell apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035556
      label: intracellular signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042045
      label: epithelial fluid transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042482
      label: positive regulation of odontogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042554
      label: superoxide anion generation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045178
      label: basal part of cell
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045944
      label: positive regulation of transcription by RNA polymerase II
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045987
      label: positive regulation of smooth muscle contraction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046888
      label: negative regulation of hormone secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048237
      label: rough endoplasmic reticulum lumen
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051899
      label: membrane depolarization
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090023
      label: positive regulation of neutrophil chemotaxis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1901224
      label: positive regulation of non-canonical NF-kappaB signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904707
      label: positive regulation of vascular associated smooth muscle cell 
        proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900182
      label: positive regulation of protein localization to nucleus
    evidence_type: IMP
    original_reference_id: PMID:21525433
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21525433
          supporting_text: Endothelin-1 contributes to increased NFATc3 
            activation by chronic hypoxia in pulmonary arteries.
  - term:
      id: GO:1905653
      label: positive regulation of artery morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:20495147
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20495147
          supporting_text: NFATc3 contributes to intermittent hypoxia-induced 
            arterial remodeling in mice.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0007411
      label: axon guidance
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:16868309
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16868309
          supporting_text: Collecting duct-specific knockout of the endothelin B
            receptor causes hypertension and sodium retention.
  - term:
      id: GO:0048675
      label: axon extension
    evidence_type: IDA
    original_reference_id: PMID:18401410
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18401410
          supporting_text: Endothelins are vascular-derived axonal guidance cues
            for developing sympathetic neurons.
  - term:
      id: GO:0000165
      label: MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0000165
      label: MAPK cascade
    evidence_type: IMP
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0044751
      label: cellular response to human chorionic gonadotropin stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0071372
      label: cellular response to follicle-stimulating hormone stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0071373
      label: cellular response to luteinizing hormone stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:1903537
      label: meiotic cell cycle process involved in oocyte maturation
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0070371
      label: ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:20516397
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20516397
          supporting_text: Epub 2010 Jun 1. Low blood pressure in endothelial 
            cell-specific endothelin 1 knockout mice.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:20516397
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20516397
          supporting_text: Epub 2010 Jun 1. Low blood pressure in endothelial 
            cell-specific endothelin 1 knockout mice.
  - term:
      id: GO:0001569
      label: branching involved in blood vessel morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0014033
      label: neural crest cell differentiation
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0014034
      label: neural crest cell fate commitment
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0061626
      label: pharyngeal arch artery morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0070294
      label: renal sodium ion absorption
    evidence_type: IDA
    original_reference_id: PMID:23698114
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23698114
          supporting_text: Endothelin-1 inhibits sodium reabsorption by ET(A) 
            and ET(B) receptors in the mouse cortical collecting duct.
  - term:
      id: GO:0007005
      label: mitochondrion organization
    evidence_type: IDA
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0030878
      label: thyroid gland development
    evidence_type: IMP
    original_reference_id: PMID:26506449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26506449
          supporting_text: Oct 23. Postotic and preotic cranial neural crest 
            cells differently contribute to thyroid development.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0003253
      label: cardiac neural crest cell migration involved in outflow tract 
        morphogenesis
    evidence_type: IDA
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0003357
      label: noradrenergic neuron differentiation
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:31219639
    review:
      summary: >-
        OVER-ANNOTATION: Endothelin-1 (Edn1) is a secreted vasoactive peptide ligand
        that
        does NOT perform phosphorylation itself. It binds to endothelin receptors
        (Ednra,
        Ednrb) which then trigger downstream signaling cascades. PMID:31219639 (the
        same
        paper cited for the Ednra receptor over-annotation) describes signaling cascades
        triggered by Edn1/Ednra activation, but the phosphorylation is performed by
        downstream kinases activated by receptor signaling, not by Edn1 itself.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0031175
      label: neuron projection development
    evidence_type: IDA
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0060385
      label: axonogenesis involved in innervation
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0060385
      label: axonogenesis involved in innervation
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0071526
      label: semaphorin-plexin signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0097492
      label: sympathetic neuron axon guidance
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0003094
      label: glomerular filtration
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0006366
      label: transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:27026367
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27026367
          supporting_text: 2016 Mar 29. Endothelin-1 Induces Proteinuria by 
            Heparanase-Mediated Disruption of the Glomerular Glycocalyx.
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: IDA
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0060070
      label: canonical Wnt signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0070301
      label: cellular response to hydrogen peroxide
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0072011
      label: glomerular endothelium development
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0072112
      label: podocyte differentiation
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: IDA
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: IMP
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0141156
      label: cAMP/PKA signal transduction
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:2001259
      label: positive regulation of cation channel activity
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0031583
      label: phospholipase D-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: IDA
    original_reference_id: PMID:8978712
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8978712
          supporting_text: Endothelin stimulates phospholipase D in striatal 
            astrocytes.
  - term:
      id: GO:0009953
      label: dorsal/ventral pattern formation
    evidence_type: IMP
    original_reference_id: PMID:15110048
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15110048
          supporting_text: Endothelin-1 regulates the dorsoventral branchial 
            arch patterning in mice.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010827
      label: regulation of D-glucose transmembrane transport
    evidence_type: IDA
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
  - term:
      id: GO:0007193
      label: adenylate cyclase-inhibiting G protein-coupled receptor signaling 
        pathway
    evidence_type: IGI
    original_reference_id: PMID:15632412
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15632412
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            alters vasopressin regulation of urine osmolality.
  - term:
      id: GO:0007193
      label: adenylate cyclase-inhibiting G protein-coupled receptor signaling 
        pathway
    evidence_type: IDA
    original_reference_id: PMID:2542249
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2542249
          supporting_text: A novel vasoactive peptide endothelin stimulates 
            mitogenesis through inositol lipid turnover in Swiss 3T3 
            fibroblasts.
  - term:
      id: GO:0035810
      label: positive regulation of urine volume
    evidence_type: IMP
    original_reference_id: PMID:15632412
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15632412
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            alters vasopressin regulation of urine osmolality.
  - term:
      id: GO:0035810
      label: positive regulation of urine volume
    evidence_type: IGI
    original_reference_id: PMID:15632412
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15632412
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            alters vasopressin regulation of urine osmolality.
  - term:
      id: GO:0035815
      label: positive regulation of renal sodium excretion
    evidence_type: IMP
    original_reference_id: PMID:15314687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15314687
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            causes hypertension and sodium retention.
  - term:
      id: GO:0006885
      label: regulation of pH
    evidence_type: IDA
    original_reference_id: PMID:11413164
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11413164
          supporting_text: Endothelin-1/endothelin-B receptor-mediated increases
            in NHE3 activity in chronic metabolic acidosis.
  - term:
      id: GO:0001501
      label: skeletal system development
    evidence_type: IMP
    original_reference_id: PMID:8152482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8152482
          supporting_text: Elevated blood pressure and craniofacial 
            abnormalities in mice deficient in endothelin-1.
  - term:
      id: GO:0001569
      label: branching involved in blood vessel morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:7615798
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7615798
          supporting_text: Aortic arch malformations and ventricular septal 
            defect in mice deficient in endothelin-1.
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: IMP
    original_reference_id: PMID:8764295
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8764295
          supporting_text: Impaired ventilatory responses to hypoxia and 
            hypercapnia in mutant mice deficient in endothelin-1.
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IDA
    original_reference_id: PMID:2542249
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2542249
          supporting_text: A novel vasoactive peptide endothelin stimulates 
            mitogenesis through inositol lipid turnover in Swiss 3T3 
            fibroblasts.
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IDA
    original_reference_id: PMID:8680799
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8680799
          supporting_text: Developmental changes in cerebellar endothelin-1 
            receptors in the neurologic mouse lurcher mutant.
  - term:
      id: GO:0007200
      label: phospholipase C-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: IDA
    original_reference_id: PMID:2542249
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2542249
          supporting_text: A novel vasoactive peptide endothelin stimulates 
            mitogenesis through inositol lipid turnover in Swiss 3T3 
            fibroblasts.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IMP
    original_reference_id: PMID:7615798
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7615798
          supporting_text: Aortic arch malformations and ventricular septal 
            defect in mice deficient in endothelin-1.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:8152482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8152482
          supporting_text: Elevated blood pressure and craniofacial 
            abnormalities in mice deficient in endothelin-1.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:2542249
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2542249
          supporting_text: A novel vasoactive peptide endothelin stimulates 
            mitogenesis through inositol lipid turnover in Swiss 3T3 
            fibroblasts.
  - term:
      id: GO:0014032
      label: neural crest cell development
    evidence_type: IMP
    original_reference_id: PMID:9671575
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9671575
          supporting_text: A signaling cascade involving endothelin-1, dHAND and
            msx1 regulates development of neural-crest-derived branchial arch 
            mesenchyme.
  - term:
      id: GO:0042474
      label: middle ear morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:8152482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8152482
          supporting_text: Elevated blood pressure and craniofacial 
            abnormalities in mice deficient in endothelin-1.
  - term:
      id: GO:0043179
      label: rhythmic excitation
    evidence_type: IMP
    original_reference_id: PMID:8764295
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8764295
          supporting_text: Impaired ventilatory responses to hypoxia and 
            hypercapnia in mutant mice deficient in endothelin-1.
  - term:
      id: GO:0045987
      label: positive regulation of smooth muscle contraction
    evidence_type: IDA
    original_reference_id: PMID:8010105
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8010105
          supporting_text: Effects of endothelin-1 on isolated uterine horns in 
            estrogen-primed and pregnant mice.
  - term:
      id: GO:0048514
      label: blood vessel morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:7615798
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7615798
          supporting_text: Aortic arch malformations and ventricular septal 
            defect in mice deficient in endothelin-1.
  - term:
      id: GO:0051216
      label: cartilage development
    evidence_type: IMP
    original_reference_id: PMID:8152482
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8152482
          supporting_text: Elevated blood pressure and craniofacial 
            abnormalities in mice deficient in endothelin-1.
  - term:
      id: GO:0001701
      label: in utero embryonic development
    evidence_type: IMP
    original_reference_id: PMID:15327783
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15327783
          supporting_text: Temporal requirement of signaling cascade involving 
            endothelin-1/endothelin receptor type A in branchial arch 
            development.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:15314687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15314687
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            causes hypertension and sodium retention.
  - term:
      id: GO:0007589
      label: body fluid secretion
    evidence_type: IMP
    original_reference_id: PMID:15314687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15314687
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            causes hypertension and sodium retention.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:15314687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15314687
          supporting_text: Collecting duct-specific knockout of endothelin-1 
            causes hypertension and sodium retention.
  - term:
      id: GO:0014032
      label: neural crest cell development
    evidence_type: IMP
    original_reference_id: PMID:15327783
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15327783
          supporting_text: Temporal requirement of signaling cascade involving 
            endothelin-1/endothelin receptor type A in branchial arch 
            development.
  - term:
      id: GO:0031707
      label: endothelin A receptor binding
    evidence_type: IPI
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:12441350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12441350
          supporting_text: Nov 18. The first inner loop of endothelin receptor 
            type B is necessary for specific coupling to Galpha 13.
  - term:
      id: GO:0007585
      label: respiratory gaseous exchange by respiratory system
    evidence_type: IMP
    original_reference_id: PMID:10626068
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10626068
          supporting_text: Endothelin in the central control of cardiovascular 
            and respiratory functions.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:10626068
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10626068
          supporting_text: Endothelin in the central control of cardiovascular 
            and respiratory functions.
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: TAS
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10626068
    title: Endothelin in the central control of cardiovascular and respiratory 
      functions.
    findings: []
  - id: PMID:11413164
    title: Endothelin-1/endothelin-B receptor-mediated increases in NHE3 
      activity in chronic metabolic acidosis.
    findings: []
  - id: PMID:11546805
    title: beta -Arrestin-mediated recruitment of the Src family kinase Yes 
      mediates endothelin-1-stimulated glucose transport.
    findings: []
  - id: PMID:12441350
    title: The first inner loop of endothelin receptor type B is necessary for 
      specific coupling to Galpha 13.
    findings: []
  - id: PMID:15110048
    title: Endothelin-1 regulates the dorsoventral branchial arch patterning in 
      mice.
    findings: []
  - id: PMID:15314687
    title: Collecting duct-specific knockout of endothelin-1 causes hypertension
      and sodium retention.
    findings: []
  - id: PMID:15327783
    title: Temporal requirement of signaling cascade involving 
      endothelin-1/endothelin receptor type A in branchial arch development.
    findings: []
  - id: PMID:15632412
    title: Collecting duct-specific knockout of endothelin-1 alters vasopressin 
      regulation of urine osmolality.
    findings: []
  - id: PMID:16868309
    title: Collecting duct-specific knockout of the endothelin B receptor causes
      hypertension and sodium retention.
    findings: []
  - id: PMID:18401410
    title: Endothelins are vascular-derived axonal guidance cues for developing 
      sympathetic neurons.
    findings: []
  - id: PMID:19111534
    title: Paracrine regulation of the resumption of oocyte meiosis by 
      endothelin-1.
    findings: []
  - id: PMID:20495147
    title: NFATc3 contributes to intermittent hypoxia-induced arterial 
      remodeling in mice.
    findings: []
  - id: PMID:20516397
    title: Low blood pressure in endothelial cell-specific endothelin 1 knockout
      mice.
    findings: []
  - id: PMID:20929948
    title: Endothelin receptor type A expression defines a distinct cardiac 
      subdomain within the heart field and is later implicated in chamber 
      myocardium formation.
    findings: []
  - id: PMID:21525433
    title: Endothelin-1 contributes to increased NFATc3 activation by chronic 
      hypoxia in pulmonary arteries.
    findings: []
  - id: PMID:23698114
    title: Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) 
      receptors in the mouse cortical collecting duct.
    findings: []
  - id: PMID:23933587
    title: Endothelin regulates neural crest deployment and fate to form great 
      vessels through Dlx5/Dlx6-independent mechanisms.
    findings: []
  - id: PMID:24722437
    title: Direct action of endothelin-1 on podocytes promotes diabetic 
      glomerulosclerosis.
    findings: []
  - id: PMID:24875861
    title: Venous endothelin guides sympathetic innervation of the developing 
      mouse heart.
    findings: []
  - id: PMID:25197047
    title: Essential role of sympathetic endothelin A receptors for adverse 
      cardiac remodeling.
    findings: []
  - id: PMID:2542249
    title: A novel vasoactive peptide endothelin stimulates mitogenesis through 
      inositol lipid turnover in Swiss 3T3 fibroblasts.
    findings: []
  - id: PMID:26506449
    title: Postotic and preotic cranial neural crest cells differently 
      contribute to thyroid development.
    findings: []
  - id: PMID:27026367
    title: Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of
      the Glomerular Glycocalyx.
    findings: []
  - id: PMID:27899487
    title: Glomerular Endothelial Mitochondrial Dysfunction Is Essential and 
      Characteristic of Diabetic Kidney Disease Susceptibility.
    findings: []
  - id: PMID:30735130
    title: Venous endothelin modulates responsiveness of cardiac sympathetic 
      axons to arterial semaphorin.
    findings: []
  - id: PMID:30990108
    title: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization of TRPA1
      channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
    findings: []
  - id: PMID:31219639
    title: Cdc42 activation by endothelin regulates neural crest cell migration 
      in the cardiac outflow tract.
    findings: []
  - id: PMID:31402170
    title: Endothelin receptor-A mediates degradation of the glomerular 
      endothelial surface layer via pathologic crosstalk between activated 
      podocytes and glomerular endothelial cells.
    findings: []
  - id: PMID:7615798
    title: Aortic arch malformations and ventricular septal defect in mice 
      deficient in endothelin-1.
    findings: []
  - id: PMID:8010105
    title: Effects of endothelin-1 on isolated uterine horns in estrogen-primed 
      and pregnant mice.
    findings: []
  - id: PMID:8152482
    title: Elevated blood pressure and craniofacial abnormalities in mice 
      deficient in endothelin-1.
    findings: []
  - id: PMID:8680799
    title: Developmental changes in cerebellar endothelin-1 receptors in the 
      neurologic mouse lurcher mutant.
    findings: []
  - id: PMID:8764295
    title: Impaired ventilatory responses to hypoxia and hypercapnia in mutant 
      mice deficient in endothelin-1.
    findings: []
  - id: PMID:8978712
    title: Endothelin stimulates phospholipase D in striatal astrocytes.
    findings: []
  - id: PMID:9449664
    title: Cranial and cardiac neural crest defects in endothelin-A 
      receptor-deficient mice.
    findings: []
  - id: PMID:9671575
    title: A signaling cascade involving endothelin-1, dHAND and msx1 regulates 
      development of neural-crest-derived branchial arch mesenchyme.
    findings: []