Ednra

Summary: The pigmentation node sits above the EDNRA/EDNRB split, so the term is an over-annotation for mouse Ednra rather than a refuted claim.

Reason: Two of the three seeds behind this IBA are endothelin receptor type B records (MGI:MGI:102720 and RGD:2536; the accessions P48302 and P21451 are asserted from external knowledge and are NOT checkable here - Ednra's family PTHR46099 has no local directory, P21451 appears nowhere in the repository, and P48302 appears only as an unnamed WITH/FROM entry in Edn1-goa.tsv), and in mammals the pigmentation arm of endothelin signalling runs through the EDN3/EDNRB axis, with no pigmentation evidence anywhere in the mouse Ednra GOA. However, the third seed, ZFIN:ZDB-GENE-010906-2, is zebrafish ednraa (B3DLG5) - again asserted from external knowledge, since B3DLG5 appears nowhere in the repository - an EDNRA-type ortholog that carries its own IMP to this term from the zebrafish pigmentation-mutant screen PMID:9007256. The node assertion is therefore not purely EDNRB-derived, and PANTHER node PTN002517505 spans both paralogs, so descent from it cannot say which receptor carries the role in mouse. That last point is the one part of this block that is locally checkable and it does not depend on the donor identities above: Ednra-goa.tsv line 3 cites the same node with MGI:MGI:102720 and MGI:MGI:105923 together, and Ednra-uniprot.txt line 122 identifies MGI:105923 as Ednra itself, so the node draws on two distinct mouse genes, one of them the review target. Their receptor typing is asserted, not local; the distinctness is what the span argument needs. That is grounds for treating the row as an over-annotation of mouse Ednra, not for removing it as a paralog artifact.

Summary: endothelin receptor signaling pathway is biologically consistent with the curated synthesis for Ednra and is supported by IBA evidence (GO_REF:0000033).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: plasma membrane is biologically consistent with the curated synthesis for Ednra and is supported by IBA evidence (GO_REF:0000033).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: endothelin receptor activity is biologically consistent with the curated synthesis for Ednra and is supported by IBA evidence (GO_REF:0000033).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: vasoconstriction is biologically consistent with the curated synthesis for Ednra and is supported by IBA evidence (GO_REF:0000033).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: G protein-coupled receptor activity captures the right general biology for Ednra, but a more specific GO term is available.

Reason: The current term is too broad or less precise than endothelin receptor activity for this gene. Replace with endothelin receptor activity to align the annotation with the reviewed evidence.

Proposed replacements: endothelin receptor activity

Summary: endothelin receptor activity is biologically consistent with the curated synthesis for Ednra and is supported by IEA evidence (GO_REF:0000120).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: plasma membrane is biologically consistent with the curated synthesis for Ednra and is supported by IEA evidence (GO_REF:0000120).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: signal transduction captures the right general biology for Ednra, but a more specific GO term is available.

Reason: The current term is too broad or less precise than endothelin receptor signaling pathway for this gene. Replace with endothelin receptor signaling pathway to align the annotation with the reviewed evidence.

Proposed replacements: endothelin receptor signaling pathway

Summary: G protein-coupled receptor signaling pathway captures the right general biology for Ednra, but a more specific GO term is available.

Reason: The current term is too broad or less precise than endothelin receptor signaling pathway for this gene. Replace with endothelin receptor signaling pathway to align the annotation with the reviewed evidence.

Proposed replacements: endothelin receptor signaling pathway

Summary: blood circulation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: membrane is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: heparin proteoglycan metabolic process is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: vasoconstriction is biologically consistent with the curated synthesis for Ednra and is supported by IEA evidence (GO_REF:0000120).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: positive regulation of canonical NF-kappaB signal transduction is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: enteric nervous system development is not supported as an appropriate annotation for Ednra after review of the available mouse evidence.

Reason: The term appears to reflect either an unsupported transfer, a paralog/family overreach, or a localization/process inconsistent with the curated Ednra biology.

Summary: sodium ion homeostasis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: establishment of endothelial barrier is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: renal sodium ion absorption is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: protein transmembrane transport is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: podocyte differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: renal albumin absorption is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: intracellular calcium ion homeostasis is too broad relative to the more specific EDNRA calcium-signaling annotations retained elsewhere.

Reason: EDNRA-dependent PLC/calcium signaling is better captured by the specific cytosolic-calcium and podocyte calcium annotations than by this broad homeostasis term.

Summary: artery smooth muscle contraction is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cAMP/PKA signal transduction is supported in a DRG pain-sensitization context but is not the core EDNRA receptor function.

Reason: PMID:30990108 supports ETAR-PKA-mediated TRPA1 sensitization; this is a context-specific nociceptive signaling branch rather than the central endothelin receptor/PLC/calcium pathway.

Summary: plasma membrane is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000119).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: positive regulation of protein phosphorylation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: histamine secretion is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: glomerular filtration is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: endothelin receptor activity is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000096).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: phospholipase C-activating G protein-coupled receptor signaling pathway is a specific supported branch of EDNRA signaling.

Reason: EDNRA is an endothelin GPCR whose reviewed evidence explicitly supports Gq/G11-dependent PLC/phosphatidylinositol-calcium signaling, so this mechanistic pathway term should be retained.

Summary: positive regulation of cytosolic calcium ion concentration is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000096).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: Rho protein signal transduction is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: positive regulation of cell population proliferation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: artery smooth muscle contraction is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: T-tubule is not supported as an appropriate annotation for Ednra after review of the available mouse evidence.

Reason: The term appears to reflect either an unsupported transfer, a paralog/family overreach, or a localization/process inconsistent with the curated Ednra biology.

Summary: nuclear membrane is not supported as an appropriate annotation for Ednra after review of the available mouse evidence.

Reason: The term appears to reflect either an unsupported transfer, a paralog/family overreach, or a localization/process inconsistent with the curated Ednra biology.

Summary: response to lipopolysaccharide is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: vasoconstriction is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000096).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: vasoconstriction is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000119).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: positive regulation of odontogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: negative regulation of apoptotic process is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: fibroblast proliferation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: smooth muscle cell proliferation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: regulation of epithelial cell proliferation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: positive regulation of release of sequestered calcium ion into cytosol is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000096).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: positive regulation of calcium ion transport is biologically consistent with the curated synthesis for Ednra and is supported by ISO evidence (GO_REF:0000096).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: positive regulation of ERK1 and ERK2 cascade is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: cellular response to mechanical stimulus is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: positive regulation of neutrophil chemotaxis is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: positive regulation of kidney development is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: endothelin receptor activity is biologically consistent with the curated synthesis for Ednra and is supported by IMP evidence (PMID:24722437).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: endothelin receptor signaling pathway is biologically consistent with the curated synthesis for Ednra and is supported by IMP evidence (PMID:24722437).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: heart process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: heart process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: axon guidance is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: aorta development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of heart rate is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of heart rate is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: axon guidance is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell fate commitment is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: axon extension is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: face development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: face development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: mesenchymal cell apoptotic process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cranial skeletal system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cranial skeletal system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cranial skeletal system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to human chorionic gonadotropin stimulus is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to human chorionic gonadotropin stimulus is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to follicle-stimulating hormone stimulus is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to luteinizing hormone stimulus is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: meiotic cell cycle process involved in oocyte maturation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: mitotic cell cycle is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: cardiac chamber formation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: left ventricular cardiac muscle tissue morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: atrial cardiac muscle tissue development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: gene expression is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: neural crest cell differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic heart tube development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: middle ear morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: sodium ion homeostasis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cranial skeletal system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: angiogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: branching involved in blood vessel morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell fate commitment is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: pharyngeal arch artery morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: renal sodium ion absorption is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: blood vessel remodeling is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: mitochondrion organization is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: specification of segmental identity, maxillary segment is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: heart development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: response to wounding is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neuron remodeling is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: thyroid gland development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: glomerulus development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to oxidative stress is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: specification of segmental identity, mandibular segment is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: norepinephrine metabolic process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: sympathetic nervous system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic skeletal system development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neuromuscular process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: renal albumin absorption is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: vascular associated smooth muscle cell development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: podocyte apoptotic process is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: response to amphetamine is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cardiac neural crest cell migration involved in outflow tract morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: noradrenergic neuron differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: protein phosphorylation is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: heart development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: regulation of blood pressure is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: gene expression is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: gene expression is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: neuron projection development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neuron projection development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic heart tube development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic heart tube development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic heart tube development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: embryonic heart tube development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: aorta development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: axonogenesis involved in innervation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: axonogenesis involved in innervation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: pharyngeal arch artery morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: semaphorin-plexin signaling pathway is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: endothelin receptor signaling pathway is biologically consistent with the curated synthesis for Ednra and is supported by IMP evidence (PMID:31219639).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: sympathetic neuron axon guidance is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: response to acetylcholine is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: regulation of protein localization to cell leading edge is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: glomerular filtration is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: plasma membrane is biologically consistent with the curated synthesis for Ednra and is supported by IDA evidence (PMID:30990108).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: This DRG pain study supports ETAR/TRPA1 sensitization rather than a core intracellular calcium homeostasis annotation.

Reason: ET-1 did not induce robust calcium signals in native mouse DRG neurons; Ednra calcium signaling is better captured by the more specific retained cytosolic-calcium and podocyte calcium annotations.

Summary: This DRG pain study supports ETAR/TRPA1 sensitization rather than a core intracellular calcium homeostasis annotation.

Reason: ET-1 did not induce robust calcium signals in native mouse DRG neurons; Ednra calcium signaling is better captured by the more specific retained cytosolic-calcium and podocyte calcium annotations.

Summary: gene expression is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: canonical Wnt signaling pathway is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to hydrogen peroxide is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: calcium ion transmembrane transport is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: calcium ion transmembrane transport is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: calcium ion transmembrane transport is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: glomerular endothelium development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: podocyte differentiation is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: endothelin receptor signaling pathway is biologically consistent with the curated synthesis for Ednra and is supported by IGI evidence (PMID:24722437).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: renal albumin absorption is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: cellular response to toxic substance is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: cellular response to toxic substance is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: cellular response to toxic substance is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: cAMP/PKA signal transduction is supported in a DRG pain-sensitization context but is not the core EDNRA receptor function.

Reason: PMID:30990108 supports ETAR-PKA-mediated TRPA1 sensitization; this is a context-specific nociceptive signaling branch rather than the central endothelin receptor/PLC/calcium pathway.

Summary: positive regulation of cation channel activity is supported in a DRG TRPA1 sensitization context but is not core EDNRA receptor identity.

Reason: PMID:30990108 directly supports ETAR-dependent TRPA1 channel sensitization as a pain-specific signaling output, so the term is retained as non-core rather than treated as the primary receptor function.

Summary: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: regulation of D-glucose transmembrane transport is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: head development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: protein binding is not supported as an appropriate annotation for Ednra after review of the available mouse evidence.

Reason: The term appears to reflect either an unsupported transfer, a paralog/family overreach, or a localization/process inconsistent with the curated Ednra biology.

Summary: response to hypoxia is related to reported Ednra biology only as a broad downstream readout or generic interaction term.

Reason: This overstates the direct role of the gene product; the curated model is better captured by the specific receptor/ligand, pathway, and supported non-core phenotype terms.

Summary: in utero embryonic development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: endothelin receptor activity is biologically consistent with the curated synthesis for Ednra and is supported by IMP evidence (PMID:9449664).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: protein binding is not supported as an appropriate annotation for Ednra after review of the available mouse evidence.

Reason: The term appears to reflect either an unsupported transfer, a paralog/family overreach, or a localization/process inconsistent with the curated Ednra biology.

Summary: respiratory gaseous exchange by respiratory system is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: neural crest cell development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: vasoconstriction is biologically consistent with the curated synthesis for Ednra and is supported by IMP evidence (PMID:9826706).

Reason: The term matches a direct molecular function, pathway, or location/physiological output of Ednra; it is specific enough to retain without replacement.

Summary: branching involved in blood vessel morphogenesis is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: heart development is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: respiratory gaseous exchange by respiratory system is supported for Ednra in a tissue, developmental, trafficking, or disease-model context, but it is not the core molecular role.

Reason: This annotation captures a real downstream or context-specific consequence of Ednra activity. It should be retained as non-core so it does not obscure the primary receptor/ligand signaling function.

Summary: G protein-coupled receptor activity captures the right general biology for Ednra, but a more specific GO term is available.

Reason: The current term is too broad or less precise than endothelin receptor activity for this gene. Replace with endothelin receptor activity to align the annotation with the reviewed evidence.

Proposed replacements: endothelin receptor activity

Summary: G protein-coupled receptor signaling pathway captures the right general biology for Ednra, but a more specific GO term is available.

Reason: The current term is too broad or less precise than endothelin receptor signaling pathway for this gene. Replace with endothelin receptor signaling pathway to align the annotation with the reviewed evidence.

Proposed replacements: endothelin receptor signaling pathway