Ednra

id: Q61614
gene_symbol: Ednra
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ednra'
existing_annotations:
  - term:
      id: GO:0048066
      label: developmental pigmentation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004962
      label: endothelin receptor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004962
      label: endothelin receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008015
      label: blood circulation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030202
      label: heparin proteoglycan metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043123
      label: positive regulation of canonical NF-kappaB signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048484
      label: enteric nervous system development
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0055078
      label: sodium ion homeostasis
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061028
      label: establishment of endothelial barrier
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070294
      label: renal sodium ion absorption
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071806
      label: protein transmembrane transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072112
      label: podocyte differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097018
      label: renal albumin absorption
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014824
      label: artery smooth muscle contraction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0141156
      label: cAMP/PKA signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001821
      label: histamine secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003094
      label: glomerular filtration
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004962
      label: endothelin receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007200
      label: phospholipase C-activating G protein-coupled receptor signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007204
      label: positive regulation of cytosolic calcium ion concentration
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007266
      label: Rho protein signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0014824
      label: artery smooth muscle contraction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030315
      label: T-tubule
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031965
      label: nuclear membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032496
      label: response to lipopolysaccharide
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042482
      label: positive regulation of odontogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048144
      label: fibroblast proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048659
      label: smooth muscle cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050678
      label: regulation of epithelial cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051281
      label: positive regulation of release of sequestered calcium ion into 
        cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051928
      label: positive regulation of calcium ion transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071260
      label: cellular response to mechanical stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090023
      label: positive regulation of neutrophil chemotaxis
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090184
      label: positive regulation of kidney development
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004962
      label: endothelin receptor activity
    evidence_type: IMP
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0003015
      label: heart process
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0007411
      label: axon guidance
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0035904
      label: aorta development
    evidence_type: IMP
    original_reference_id: PMID:14585980
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14585980
          supporting_text: Cardiomyocyte-specific endothelin A receptor knockout
            mice have normal cardiac function and an unaltered hypertrophic 
            response to angiotensin II and isoproterenol.
  - term:
      id: GO:0002027
      label: regulation of heart rate
    evidence_type: IMP
    original_reference_id: PMID:16399858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16399858
          supporting_text: Blood pressure regulation by ETA and ETB receptors in
            conscious, telemetry-instrumented mice and role of ETA in 
            hypertension produced by selective ETB blockade.
  - term:
      id: GO:0002027
      label: regulation of heart rate
    evidence_type: IGI
    original_reference_id: PMID:16399858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16399858
          supporting_text: Blood pressure regulation by ETA and ETB receptors in
            conscious, telemetry-instrumented mice and role of ETA in 
            hypertension produced by selective ETB blockade.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:16399858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16399858
          supporting_text: Blood pressure regulation by ETA and ETB receptors in
            conscious, telemetry-instrumented mice and role of ETA in 
            hypertension produced by selective ETB blockade.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IGI
    original_reference_id: PMID:16399858
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16399858
          supporting_text: Blood pressure regulation by ETA and ETB receptors in
            conscious, telemetry-instrumented mice and role of ETA in 
            hypertension produced by selective ETB blockade.
  - term:
      id: GO:0007411
      label: axon guidance
    evidence_type: IMP
    original_reference_id: PMID:18401410
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18401410
          supporting_text: Endothelins are vascular-derived axonal guidance cues
            for developing sympathetic neurons.
  - term:
      id: GO:0014034
      label: neural crest cell fate commitment
    evidence_type: IMP
    original_reference_id: PMID:17294360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17294360
          supporting_text: Fate of cranial neural crest cells during 
            craniofacial development in endothelin-A receptor-deficient mice.
  - term:
      id: GO:0048675
      label: axon extension
    evidence_type: IMP
    original_reference_id: PMID:18401410
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18401410
          supporting_text: Endothelins are vascular-derived axonal guidance cues
            for developing sympathetic neurons.
  - term:
      id: GO:0060324
      label: face development
    evidence_type: IDA
    original_reference_id: PMID:18199583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18199583
          supporting_text: Recombinase-mediated cassette exchange reveals the 
            selective use of Gq/G11-dependent and -independent endothelin 
            1/endothelin type A receptor signaling in pharyngeal arch 
            development.
  - term:
      id: GO:0060324
      label: face development
    evidence_type: IMP
    original_reference_id: PMID:18199583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18199583
          supporting_text: Recombinase-mediated cassette exchange reveals the 
            selective use of Gq/G11-dependent and -independent endothelin 
            1/endothelin type A receptor signaling in pharyngeal arch 
            development.
  - term:
      id: GO:0097152
      label: mesenchymal cell apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:17294360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17294360
          supporting_text: Fate of cranial neural crest cells during 
            craniofacial development in endothelin-A receptor-deficient mice.
  - term:
      id: GO:1904888
      label: cranial skeletal system development
    evidence_type: IMP
    original_reference_id: PMID:17294360
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17294360
          supporting_text: Fate of cranial neural crest cells during 
            craniofacial development in endothelin-A receptor-deficient mice.
  - term:
      id: GO:1904888
      label: cranial skeletal system development
    evidence_type: IDA
    original_reference_id: PMID:18199583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18199583
          supporting_text: Recombinase-mediated cassette exchange reveals the 
            selective use of Gq/G11-dependent and -independent endothelin 
            1/endothelin type A receptor signaling in pharyngeal arch 
            development.
  - term:
      id: GO:1904888
      label: cranial skeletal system development
    evidence_type: IMP
    original_reference_id: PMID:18199583
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18199583
          supporting_text: Recombinase-mediated cassette exchange reveals the 
            selective use of Gq/G11-dependent and -independent endothelin 
            1/endothelin type A receptor signaling in pharyngeal arch 
            development.
  - term:
      id: GO:0044751
      label: cellular response to human chorionic gonadotropin stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0044751
      label: cellular response to human chorionic gonadotropin stimulus
    evidence_type: IMP
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0071372
      label: cellular response to follicle-stimulating hormone stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0071373
      label: cellular response to luteinizing hormone stimulus
    evidence_type: IDA
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:1903537
      label: meiotic cell cycle process involved in oocyte maturation
    evidence_type: IMP
    original_reference_id: PMID:19111534
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19111534
          supporting_text: Dec 7. Paracrine regulation of the resumption of 
            oocyte meiosis by endothelin-1.
  - term:
      id: GO:0000278
      label: mitotic cell cycle
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0003207
      label: cardiac chamber formation
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0003220
      label: left ventricular cardiac muscle tissue morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0003228
      label: atrial cardiac muscle tissue development
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IGI
    original_reference_id: PMID:18784261
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18784261
          supporting_text: Combined knockout of collecting duct endothelin A and
            B receptors causes hypertension and sodium retention.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0014033
      label: neural crest cell differentiation
    evidence_type: IMP
    original_reference_id: PMID:19185569
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19185569
          supporting_text: 2009 Jan 13. Elucidating timing and function of 
            endothelin-A receptor signaling during craniofacial development 
            using neural crest cell-specific gene deletion and receptor 
            antagonism.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:20929948
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20929948
          supporting_text: Endothelin receptor type A expression defines a 
            distinct cardiac subdomain within the heart field and is later 
            implicated in chamber myocardium formation.
  - term:
      id: GO:0042474
      label: middle ear morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:19185569
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19185569
          supporting_text: 2009 Jan 13. Elucidating timing and function of 
            endothelin-A receptor signaling during craniofacial development 
            using neural crest cell-specific gene deletion and receptor 
            antagonism.
  - term:
      id: GO:0055078
      label: sodium ion homeostasis
    evidence_type: IGI
    original_reference_id: PMID:18784261
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18784261
          supporting_text: Combined knockout of collecting duct endothelin A and
            B receptors causes hypertension and sodium retention.
  - term:
      id: GO:1904888
      label: cranial skeletal system development
    evidence_type: IMP
    original_reference_id: PMID:19185569
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19185569
          supporting_text: 2009 Jan 13. Elucidating timing and function of 
            endothelin-A receptor signaling during craniofacial development 
            using neural crest cell-specific gene deletion and receptor 
            antagonism.
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IGI
    original_reference_id: PMID:24043815
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24043815
          supporting_text: Endothelin-2 signaling in the neural retina promotes 
            the endothelial tip cell state and inhibits angiogenesis.
  - term:
      id: GO:0001569
      label: branching involved in blood vessel morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0014033
      label: neural crest cell differentiation
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0014034
      label: neural crest cell fate commitment
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0061626
      label: pharyngeal arch artery morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:23933587
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23933587
          supporting_text: 2013 Aug 8. Endothelin regulates neural crest 
            deployment and fate to form great vessels through 
            Dlx5/Dlx6-independent mechanisms.
  - term:
      id: GO:0070294
      label: renal sodium ion absorption
    evidence_type: IMP
    original_reference_id: PMID:23698114
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23698114
          supporting_text: Endothelin-1 inhibits sodium reabsorption by ET(A) 
            and ET(B) receptors in the mouse cortical collecting duct.
  - term:
      id: GO:0001974
      label: blood vessel remodeling
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0007005
      label: mitochondrion organization
    evidence_type: IDA
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0007382
      label: specification of segmental identity, maxillary segment
    evidence_type: IMP
    original_reference_id: PMID:19017795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19017795
          supporting_text: An endothelin-1 switch specifies maxillomandibular 
            identity.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:24412386
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24412386
          supporting_text: Jan 8. Smooth muscle specific disruption of the 
            endothelin-A receptor in mice reduces arterial pressure, and 
            vascular reactivity and affects vascular development.
  - term:
      id: GO:0009611
      label: response to wounding
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0014033
      label: neural crest cell differentiation
    evidence_type: IGI
    original_reference_id: PMID:28455376
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:28455376
          supporting_text: Apr 28. Negative regulation of endothelin signaling 
            by SIX1 is required for proper maxillary development.
  - term:
      id: GO:0016322
      label: neuron remodeling
    evidence_type: IMP
    original_reference_id: PMID:19017795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19017795
          supporting_text: An endothelin-1 switch specifies maxillomandibular 
            identity.
  - term:
      id: GO:0030878
      label: thyroid gland development
    evidence_type: IMP
    original_reference_id: PMID:26506449
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26506449
          supporting_text: Oct 23. Postotic and preotic cranial neural crest 
            cells differently contribute to thyroid development.
  - term:
      id: GO:0032835
      label: glomerulus development
    evidence_type: IMP
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0034599
      label: cellular response to oxidative stress
    evidence_type: IMP
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0042305
      label: specification of segmental identity, mandibular segment
    evidence_type: IMP
    original_reference_id: PMID:19017795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19017795
          supporting_text: An endothelin-1 switch specifies maxillomandibular 
            identity.
  - term:
      id: GO:0042415
      label: norepinephrine metabolic process
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0048485
      label: sympathetic nervous system development
    evidence_type: IMP
    original_reference_id: PMID:25197047
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25197047
          supporting_text: Essential role of sympathetic endothelin A receptors 
            for adverse cardiac remodeling.
  - term:
      id: GO:0048706
      label: embryonic skeletal system development
    evidence_type: IGI
    original_reference_id: PMID:19017795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19017795
          supporting_text: An endothelin-1 switch specifies maxillomandibular 
            identity.
  - term:
      id: GO:0050905
      label: neuromuscular process
    evidence_type: IMP
    original_reference_id: PMID:19017795
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19017795
          supporting_text: An endothelin-1 switch specifies maxillomandibular 
            identity.
  - term:
      id: GO:0097018
      label: renal albumin absorption
    evidence_type: IMP
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0097084
      label: vascular associated smooth muscle cell development
    evidence_type: IMP
    original_reference_id: PMID:24412386
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24412386
          supporting_text: Jan 8. Smooth muscle specific disruption of the 
            endothelin-A receptor in mice reduces arterial pressure, and 
            vascular reactivity and affects vascular development.
  - term:
      id: GO:1903210
      label: podocyte apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:27899487
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:27899487
          supporting_text: Glomerular Endothelial Mitochondrial Dysfunction Is 
            Essential and Characteristic of Diabetic Kidney Disease 
            Susceptibility.
  - term:
      id: GO:0001975
      label: response to amphetamine
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0003253
      label: cardiac neural crest cell migration involved in outflow tract 
        morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0003357
      label: noradrenergic neuron differentiation
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: >-
        OVER-ANNOTATION: Endothelin receptor A (GPCR) does not perform phosphorylation
        itself.
        PMID:31219639 shows Ednra activation leads to Cdc42 activation as part of
        a signaling
        cascade controlling neural crest cell migration. The receptor triggers downstream
        signaling, but does not catalyze phosphorylation directly.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0008217
      label: regulation of blood pressure
    evidence_type: IMP
    original_reference_id: PMID:26531127
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26531127
          supporting_text: Nov 3. Age-dependent blood pressure elevation is due 
            to increased vascular smooth muscle tone mediated by G-protein 
            signalling.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0031175
      label: neuron projection development
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0031175
      label: neuron projection development
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IGI
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0035050
      label: embryonic heart tube development
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0035904
      label: aorta development
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0060385
      label: axonogenesis involved in innervation
    evidence_type: IMP
    original_reference_id: PMID:24875861
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24875861
          supporting_text: Venous endothelin guides sympathetic innervation of 
            the developing mouse heart.
  - term:
      id: GO:0060385
      label: axonogenesis involved in innervation
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0061626
      label: pharyngeal arch artery morphogenesis
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0071526
      label: semaphorin-plexin signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0097492
      label: sympathetic neuron axon guidance
    evidence_type: IGI
    original_reference_id: PMID:30735130
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30735130
          supporting_text: Venous endothelin modulates responsiveness of cardiac
            sympathetic axons to arterial semaphorin.
  - term:
      id: GO:1905144
      label: response to acetylcholine
    evidence_type: IMP
    original_reference_id: PMID:26531127
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26531127
          supporting_text: Nov 3. Age-dependent blood pressure elevation is due 
            to increased vascular smooth muscle tone mediated by G-protein 
            signalling.
  - term:
      id: GO:1905871
      label: regulation of protein localization to cell leading edge
    evidence_type: IMP
    original_reference_id: PMID:31219639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31219639
          supporting_text: Cdc42 activation by endothelin regulates neural crest
            cell migration in the cardiac outflow tract.
  - term:
      id: GO:0003094
      label: glomerular filtration
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0006874
      label: intracellular calcium ion homeostasis
    evidence_type: IMP
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0010467
      label: gene expression
    evidence_type: IGI
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0060070
      label: canonical Wnt signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0070301
      label: cellular response to hydrogen peroxide
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IDA
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IMP
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IGI
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0072011
      label: glomerular endothelium development
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0072112
      label: podocyte differentiation
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0086100
      label: endothelin receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:24722437
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24722437
          supporting_text: 2014 Apr 10. Direct action of endothelin-1 on 
            podocytes promotes diabetic glomerulosclerosis.
  - term:
      id: GO:0097018
      label: renal albumin absorption
    evidence_type: IDA
    original_reference_id: PMID:31402170
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31402170
          supporting_text: May 22. Endothelin receptor-A mediates degradation of
            the glomerular endothelial surface layer via pathologic crosstalk 
            between activated podocytes and glomerular endothelial cells.
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: IDA
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0097237
      label: cellular response to toxic substance
    evidence_type: IMP
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0141156
      label: cAMP/PKA signal transduction
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:2001259
      label: positive regulation of cation channel activity
    evidence_type: ISO
    original_reference_id: PMID:30990108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:30990108
          supporting_text: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization
            of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
  - term:
      id: GO:0007193
      label: adenylate cyclase-inhibiting G protein-coupled receptor signaling 
        pathway
    evidence_type: IGI
    original_reference_id: PMID:15928212
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15928212
          supporting_text: Collecting duct-specific knockout of the endothelin A
            receptor alters renal vasopressin responsiveness, but not sodium 
            excretion or blood pressure.
  - term:
      id: GO:0010827
      label: regulation of D-glucose transmembrane transport
    evidence_type: IDA
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
  - term:
      id: GO:0060322
      label: head development
    evidence_type: IMP
    original_reference_id: PMID:15306564
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15306564
          supporting_text: Endothelin-A receptor-dependent and -independent 
            signaling pathways in establishing mandibular identity.
  - term:
      id: GO:0014032
      label: neural crest cell development
    evidence_type: IMP
    original_reference_id: PMID:15306564
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15306564
          supporting_text: Endothelin-A receptor-dependent and -independent 
            signaling pathways in establishing mandibular identity.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: IMP
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0001701
      label: in utero embryonic development
    evidence_type: IMP
    original_reference_id: PMID:15327783
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15327783
          supporting_text: Temporal requirement of signaling cascade involving 
            endothelin-1/endothelin receptor type A in branchial arch 
            development.
  - term:
      id: GO:0004962
      label: endothelin receptor activity
    evidence_type: IMP
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0007585
      label: respiratory gaseous exchange by respiratory system
    evidence_type: IMP
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0014032
      label: neural crest cell development
    evidence_type: IMP
    original_reference_id: PMID:15327783
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15327783
          supporting_text: Temporal requirement of signaling cascade involving 
            endothelin-1/endothelin receptor type A in branchial arch 
            development.
  - term:
      id: GO:0014032
      label: neural crest cell development
    evidence_type: IMP
    original_reference_id: PMID:9449664
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9449664
          supporting_text: Cranial and cardiac neural crest defects in 
            endothelin-A receptor-deficient mice.
  - term:
      id: GO:0042310
      label: vasoconstriction
    evidence_type: IMP
    original_reference_id: PMID:9826706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9826706
          supporting_text: Endothelin ETA receptor blockade restores NO-mediated
            endothelial function and inhibits atherosclerosis in apolipoprotein 
            E-deficient mice.
  - term:
      id: GO:0001569
      label: branching involved in blood vessel morphogenesis
    evidence_type: IGI
    original_reference_id: PMID:15664398
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15664398
          supporting_text: Roles of forkhead transcription factor Foxc2 (MFH-1) 
            and endothelin receptor A in cardiovascular morphogenesis.
  - term:
      id: GO:0007507
      label: heart development
    evidence_type: IGI
    original_reference_id: PMID:15664398
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15664398
          supporting_text: Roles of forkhead transcription factor Foxc2 (MFH-1) 
            and endothelin receptor A in cardiovascular morphogenesis.
  - term:
      id: GO:0007585
      label: respiratory gaseous exchange by respiratory system
    evidence_type: IMP
    original_reference_id: PMID:10626068
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10626068
          supporting_text: Endothelin in the central control of cardiovascular 
            and respiratory functions.
  - term:
      id: GO:0004930
      label: G protein-coupled receptor activity
    evidence_type: TAS
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
  - term:
      id: GO:0007186
      label: G protein-coupled receptor signaling pathway
    evidence_type: TAS
    original_reference_id: PMID:11546805
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11546805
          supporting_text: 2001 Sep 6. beta -Arrestin-mediated recruitment of 
            the Src family kinase Yes mediates endothelin-1-stimulated glucose 
            transport.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10626068
    title: Endothelin in the central control of cardiovascular and respiratory 
      functions.
    findings: []
  - id: PMID:11546805
    title: beta -Arrestin-mediated recruitment of the Src family kinase Yes 
      mediates endothelin-1-stimulated glucose transport.
    findings: []
  - id: PMID:14585980
    title: Cardiomyocyte-specific endothelin A receptor knockout mice have 
      normal cardiac function and an unaltered hypertrophic response to 
      angiotensin II and isoproterenol.
    findings: []
  - id: PMID:15306564
    title: Endothelin-A receptor-dependent and -independent signaling pathways 
      in establishing mandibular identity.
    findings: []
  - id: PMID:15327783
    title: Temporal requirement of signaling cascade involving 
      endothelin-1/endothelin receptor type A in branchial arch development.
    findings: []
  - id: PMID:15664398
    title: Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin 
      receptor A in cardiovascular morphogenesis.
    findings: []
  - id: PMID:15928212
    title: Collecting duct-specific knockout of the endothelin A receptor alters
      renal vasopressin responsiveness, but not sodium excretion or blood 
      pressure.
    findings: []
  - id: PMID:16399858
    title: Blood pressure regulation by ETA and ETB receptors in conscious, 
      telemetry-instrumented mice and role of ETA in hypertension produced by 
      selective ETB blockade.
    findings: []
  - id: PMID:17294360
    title: Fate of cranial neural crest cells during craniofacial development in
      endothelin-A receptor-deficient mice.
    findings: []
  - id: PMID:18199583
    title: Recombinase-mediated cassette exchange reveals the selective use of 
      Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor 
      signaling in pharyngeal arch development.
    findings: []
  - id: PMID:18401410
    title: Endothelins are vascular-derived axonal guidance cues for developing 
      sympathetic neurons.
    findings: []
  - id: PMID:18784261
    title: Combined knockout of collecting duct endothelin A and B receptors 
      causes hypertension and sodium retention.
    findings: []
  - id: PMID:19017795
    title: An endothelin-1 switch specifies maxillomandibular identity.
    findings: []
  - id: PMID:19111534
    title: Paracrine regulation of the resumption of oocyte meiosis by 
      endothelin-1.
    findings: []
  - id: PMID:19185569
    title: Elucidating timing and function of endothelin-A receptor signaling 
      during craniofacial development using neural crest cell-specific gene 
      deletion and receptor antagonism.
    findings: []
  - id: PMID:20929948
    title: Endothelin receptor type A expression defines a distinct cardiac 
      subdomain within the heart field and is later implicated in chamber 
      myocardium formation.
    findings: []
  - id: PMID:23698114
    title: Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) 
      receptors in the mouse cortical collecting duct.
    findings: []
  - id: PMID:23933587
    title: Endothelin regulates neural crest deployment and fate to form great 
      vessels through Dlx5/Dlx6-independent mechanisms.
    findings: []
  - id: PMID:24043815
    title: Endothelin-2 signaling in the neural retina promotes the endothelial 
      tip cell state and inhibits angiogenesis.
    findings: []
  - id: PMID:24412386
    title: Smooth muscle specific disruption of the endothelin-A receptor in 
      mice reduces arterial pressure, and vascular reactivity and affects 
      vascular development.
    findings: []
  - id: PMID:24722437
    title: Direct action of endothelin-1 on podocytes promotes diabetic 
      glomerulosclerosis.
    findings: []
  - id: PMID:24875861
    title: Venous endothelin guides sympathetic innervation of the developing 
      mouse heart.
    findings: []
  - id: PMID:25197047
    title: Essential role of sympathetic endothelin A receptors for adverse 
      cardiac remodeling.
    findings: []
  - id: PMID:26506449
    title: Postotic and preotic cranial neural crest cells differently 
      contribute to thyroid development.
    findings: []
  - id: PMID:26531127
    title: Age-dependent blood pressure elevation is due to increased vascular 
      smooth muscle tone mediated by G-protein signalling.
    findings: []
  - id: PMID:27899487
    title: Glomerular Endothelial Mitochondrial Dysfunction Is Essential and 
      Characteristic of Diabetic Kidney Disease Susceptibility.
    findings: []
  - id: PMID:28455376
    title: Negative regulation of endothelin signaling by SIX1 is required for 
      proper maxillary development.
    findings: []
  - id: PMID:30735130
    title: Venous endothelin modulates responsiveness of cardiac sympathetic 
      axons to arterial semaphorin.
    findings: []
  - id: PMID:30990108
    title: 'ET(A)R and protein kinase A pathway mediate ET-1 sensitization of TRPA1
      channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.'
    findings: []
  - id: PMID:31219639
    title: Cdc42 activation by endothelin regulates neural crest cell migration 
      in the cardiac outflow tract.
    findings: []
  - id: PMID:31402170
    title: Endothelin receptor-A mediates degradation of the glomerular 
      endothelial surface layer via pathologic crosstalk between activated 
      podocytes and glomerular endothelial cells.
    findings: []
  - id: PMID:9449664
    title: Cranial and cardiac neural crest defects in endothelin-A 
      receptor-deficient mice.
    findings: []
  - id: PMID:9826706
    title: Endothelin ETA receptor blockade restores NO-mediated endothelial 
      function and inhibits atherosclerosis in apolipoprotein E-deficient mice.
    findings: []