Egf

UniProt ID: P01132
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Egf

Existing Annotations Review

GO Term Evidence Action Reason
GO:0008284 positive regulation of cell population proliferation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043410 positive regulation of MAPK cascade
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005154 epidermal growth factor receptor binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005509 calcium ion binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010604 positive regulation of macromolecule metabolic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048513 animal organ development
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048731 system development
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051049 regulation of transport
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071944 cell periphery
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0080090 regulation of primary metabolic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001525 angiogenesis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001938 positive regulation of endothelial cell proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002092 positive regulation of receptor internalization
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005085 guanyl-nucleotide exchange factor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010595 positive regulation of endothelial cell migration
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030335 positive regulation of cell migration
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042327 positive regulation of phosphorylation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043410 positive regulation of MAPK cascade
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045840 positive regulation of mitotic nuclear division
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051048 negative regulation of secretion
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070062 extracellular exosome
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090263 positive regulation of canonical Wnt signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090279 regulation of calcium ion import
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900127 positive regulation of hyaluronan biosynthetic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902966 positive regulation of protein localization to early endosome
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905278 positive regulation of epithelial tube formation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000008 regulation of protein localization to cell surface
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001525 angiogenesis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001938 positive regulation of endothelial cell proliferation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0002092 positive regulation of receptor internalization
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005085 guanyl-nucleotide exchange factor activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010595 positive regulation of endothelial cell migration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030335 positive regulation of cell migration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038134 ERBB2-EGFR signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042327 positive regulation of phosphorylation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043410 positive regulation of MAPK cascade
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045840 positive regulation of mitotic nuclear division
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051048 negative regulation of secretion
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070062 extracellular exosome
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090263 positive regulation of canonical Wnt signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090279 regulation of calcium ion import
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900127 positive regulation of hyaluronan biosynthetic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902966 positive regulation of protein localization to early endosome
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1905278 positive regulation of epithelial tube formation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000008 regulation of protein localization to cell surface
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005154 epidermal growth factor receptor binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007173 epidermal growth factor receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000573 positive regulation of DNA biosynthetic process
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043410 positive regulation of MAPK cascade
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
IDA
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
GO:0048018 receptor ligand activity
IDA
PMID:14627991
Serine mutations that abrogate ligand-induced ubiquitination... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14627991
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
GO:0005615 extracellular space
IDA
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PK... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PK... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:9529375
Epidermal growth factor signaling and mitogenesis in Plcg1 n... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9529375
Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts.
GO:0048018 receptor ligand activity
IDA
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PK... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
GO:0048018 receptor ligand activity
IDA
PMID:9529375
Epidermal growth factor signaling and mitogenesis in Plcg1 n... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9529375
Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts.
GO:0005615 extracellular space
ISO
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
GO:0005615 extracellular space
IDA
PMID:22822073
Quantitation of the effect of ErbB2 on epidermal growth fact... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22822073
2012 Jul 20. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
GO:0005615 extracellular space
IDA
PMID:6248866
Detection of epidermal growth factor-urogastrone and its rec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6248866
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development.
GO:0005615 extracellular space
IDA
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metan... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture.
GO:0038134 ERBB2-EGFR signaling pathway
ISO
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
GO:0038134 ERBB2-EGFR signaling pathway
IDA
PMID:22822073
Quantitation of the effect of ErbB2 on epidermal growth fact... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22822073
2012 Jul 20. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
GO:0048018 receptor ligand activity
ISO
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) rece... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
GO:0048018 receptor ligand activity
IDA
PMID:22822073
Quantitation of the effect of ErbB2 on epidermal growth fact... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:22822073
2012 Jul 20. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:6248866
Detection of epidermal growth factor-urogastrone and its rec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6248866
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metan... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture.
GO:0048018 receptor ligand activity
IDA
PMID:6248866
Detection of epidermal growth factor-urogastrone and its rec... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6248866
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development.
GO:0048018 receptor ligand activity
IDA
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metan... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture.
GO:0043410 positive regulation of MAPK cascade
IDA
PMID:16339969
Efficient suppression of FGF-2-induced ERK activation by the... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16339969
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.
GO:0043410 positive regulation of MAPK cascade
IDA
PMID:9030684
Mutation in Sos1 dominantly enhances a weak allele of the EG... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9030684
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:8702723
The epidermal growth factor receptor couples transforming gr... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8702723
The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
GO:0005154 epidermal growth factor receptor binding
IDA
PMID:7678348
Expression of the epidermal growth factor receptor gene is r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7678348
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation.
GO:0061098 positive regulation of protein tyrosine kinase activity
IDA
PMID:7678348
Expression of the epidermal growth factor receptor gene is r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7678348
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation.
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
IDA
PMID:21186272
Activation of the neuregulin/ErbB system during physiologica... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21186272
Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.
GO:0043388 positive regulation of DNA binding
IDA
PMID:15156153
Hes binding to STAT3 mediates crosstalk between Notch and JA... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15156153
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
IDA
PMID:15156153
Hes binding to STAT3 mediates crosstalk between Notch and JA... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15156153
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
GO:0090370 negative regulation of cholesterol efflux
IDA
PMID:20037141
Inhibition of ERK1/2 and activation of liver X receptor syne... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20037141
2009 Dec 25. Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux.
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
IDA
PMID:20208556
Presenilin modulates EGFR signaling and cell transformation ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20208556
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.
GO:0051223 regulation of protein transport
ISO
PMID:19723622
Activator of G protein signaling 8 (AGS8) is required for hy... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19723622
2009 Sep 1. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).
GO:0005515 protein binding
IPI
PMID:17626015
SGIP1alpha is an endocytic protein that directly interacts w... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17626015
2007 Jul 10. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
GO:0005886 plasma membrane
IDA
PMID:17626015
SGIP1alpha is an endocytic protein that directly interacts w... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17626015
2007 Jul 10. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
GO:0008083 growth factor activity
ISO
GO_REF:0000008 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISO
GO_REF:0000008 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005154 epidermal growth factor receptor binding
IDA
PMID:6315706
Epidermal growth factor-like transforming growth factor. II.... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6315706
Epidermal growth factor-like transforming growth factor.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:6315706
Epidermal growth factor-like transforming growth factor. II.... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6315706
Epidermal growth factor-like transforming growth factor.
GO:0060749 mammary gland alveolus development
IGI
PMID:10331984
Targeted inactivation of the EGF and amphiregulin genes reve... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10331984
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
GO:0005576 extracellular region
TAS
Reactome:R-MMU-179883 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-179883 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IDA
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosylt... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.
GO:0007173 epidermal growth factor receptor signaling pathway
IGI
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosylt... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.
GO:0008284 positive regulation of cell population proliferation
IGI
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosylt... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
IDA
PMID:10027293
Control of neuronal precursor proliferation in the cerebellu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10027293
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
GO:0008284 positive regulation of cell population proliferation
IGI
PMID:15051883
Neuropoietin, a new IL-6-related cytokine signaling through ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15051883
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
GO:0048754 branching morphogenesis of an epithelial tube
IDA
PMID:15831470
Integrin-linked kinase mediates bone morphogenetic protein 7... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15831470
Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis.
GO:0007173 epidermal growth factor receptor signaling pathway
IDA
PMID:15695332
Suppressor of cytokine signaling (SOCS)-5 is a potential neg... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15695332
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:15695332
Suppressor of cytokine signaling (SOCS)-5 is a potential neg... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15695332
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
GO:0008284 positive regulation of cell population proliferation
IDA
PMID:14712229
G-protein-coupled receptor-mediated activation of rap GTPase... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:14712229
G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.
GO:0008284 positive regulation of cell population proliferation
IGI
PMID:15509736
Fibroblast growth factor receptor signaling promotes radial ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15509736
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.
GO:0005615 extracellular space
IDA
PMID:8240367
An inborn error in epidermal growth factor prohormone metabo... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8240367
An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease.
GO:0018108 peptidyl-tyrosine phosphorylation
IDA
PMID:14561752
N-acetylglucosaminyltransferase V expression levels regulate... 		MODIFY
Summary: OVER-ANNOTATION: EGF is a secreted growth factor ligand that does NOT perform phosphorylation itself. It binds to EGFR (EGF receptor), which is a receptor tyrosine kinase that performs the actual phosphorylation. PMID:14561752 shows that EGF stimulates tyrosine phosphorylation of catenins, but the kinase activity belongs to EGFR, not to EGF. The correct annotation for EGF should be GO:0050730 "regulation of peptidyl-tyrosine phosphorylation" (already annotated) or GO:0030297 "transmembrane receptor protein tyrosine kinase activator activity" (also already annotated).
Supporting Evidence:
PMID:14561752
2003 Oct 15. N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways.
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
IDA
PMID:11940581
Protein kinase C-alpha and protein kinase C-epsilon are requ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11940581
2002 Apr 8. Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000008
Gene Ontology annotation by the MGI curatorial staff, curated orthology
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10027293
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
PMID:10331984
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
PMID:11336639
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
PMID:11823423
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
PMID:11940581
Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
PMID:12761849
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
PMID:14561752
N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways.
PMID:14627991
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
PMID:14712229
G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.
PMID:15051883
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
PMID:15156153
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
PMID:15509736
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.
PMID:15695332
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
PMID:15831470
Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis.
PMID:16339969
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.
PMID:17626015
SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15.
PMID:19723622
Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).
PMID:20037141
Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux.
PMID:20208556
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.
PMID:21186272
Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.
PMID:22822073
Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
PMID:6248866
Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development.
PMID:6315706
Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.
PMID:7641815
Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.
PMID:7678348
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation.
PMID:7752576
Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture.
PMID:8240367
An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease.
PMID:8702723
The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
PMID:9030684
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
PMID:9529375
Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts.
Reactome:R-MMU-179883
Mouse pro-EGF is cleaved by ADAM sheddases

📄 View Raw YAML

 
id: P01132
gene_symbol: Egf
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Egf'
existing_annotations:
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005154
      label: epidermal growth factor receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010604
      label: positive regulation of macromolecule metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048513
      label: animal organ development
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048731
      label: system development
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051049
      label: regulation of transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071944
      label: cell periphery
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0080090
      label: regulation of primary metabolic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002092
      label: positive regulation of receptor internalization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005085
      label: guanyl-nucleotide exchange factor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010595
      label: positive regulation of endothelial cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010800
      label: positive regulation of peptidyl-threonine phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042327
      label: positive regulation of phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051048
      label: negative regulation of secretion
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070371
      label: ERK1 and ERK2 cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090279
      label: regulation of calcium ion import
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900127
      label: positive regulation of hyaluronan biosynthetic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902966
      label: positive regulation of protein localization to early endosome
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905278
      label: positive regulation of epithelial tube formation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000008
      label: regulation of protein localization to cell surface
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001938
      label: positive regulation of endothelial cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0002092
      label: positive regulation of receptor internalization
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005085
      label: guanyl-nucleotide exchange factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010595
      label: positive regulation of endothelial cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030297
      label: transmembrane receptor protein tyrosine kinase activator activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030335
      label: positive regulation of cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038134
      label: ERBB2-EGFR signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042327
      label: positive regulation of phosphorylation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045840
      label: positive regulation of mitotic nuclear division
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051048
      label: negative regulation of secretion
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070371
      label: ERK1 and ERK2 cascade
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090263
      label: positive regulation of canonical Wnt signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0090279
      label: regulation of calcium ion import
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900127
      label: positive regulation of hyaluronan biosynthetic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902966
      label: positive regulation of protein localization to early endosome
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1905278
      label: positive regulation of epithelial tube formation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000008
      label: regulation of protein localization to cell surface
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005154
      label: epidermal growth factor receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000573
      label: positive regulation of DNA biosynthetic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030297
      label: transmembrane receptor protein tyrosine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:11823423
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11823423
          supporting_text: A mutant EGF-receptor defective in ubiquitylation and
            endocytosis unveils a role for Grb2 in negative signaling.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:14627991
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14627991
          supporting_text: Serine mutations that abrogate ligand-induced 
            ubiquitination and internalization of the EGF receptor do not affect
            c-Cbl association with the receptor.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:12761849
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12761849
          supporting_text: EGF-stimulated signaling by means of PI3K, PLCgamma1,
            and PKC isozymes regulates branching morphogenesis of the fetal 
            mouse submandibular gland.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:12761849
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12761849
          supporting_text: EGF-stimulated signaling by means of PI3K, PLCgamma1,
            and PKC isozymes regulates branching morphogenesis of the fetal 
            mouse submandibular gland.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:9529375
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9529375
          supporting_text: Epidermal growth factor signaling and mitogenesis in 
            Plcg1 null mouse embryonic fibroblasts.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:12761849
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:12761849
          supporting_text: EGF-stimulated signaling by means of PI3K, PLCgamma1,
            and PKC isozymes regulates branching morphogenesis of the fetal 
            mouse submandibular gland.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:9529375
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9529375
          supporting_text: Epidermal growth factor signaling and mitogenesis in 
            Plcg1 null mouse embryonic fibroblasts.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: PMID:11336639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11336639
          supporting_text: Heterodimerization of the epidermal-growth-factor 
            (EGF) receptor and ErbB2 and the affinity of EGF binding are 
            regulated by different mechanisms.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:22822073
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22822073
          supporting_text: 2012 Jul 20. Quantitation of the effect of ErbB2 on 
            epidermal growth factor receptor binding and dimerization.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:6248866
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6248866
          supporting_text: Detection of epidermal growth factor-urogastrone and 
            its receptor during fetal mouse development.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:7752576
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7752576
          supporting_text: Tyrosine kinase activity of the EGF receptor in 
            murine metanephric organ culture.
  - term:
      id: GO:0038134
      label: ERBB2-EGFR signaling pathway
    evidence_type: ISO
    original_reference_id: PMID:11336639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11336639
          supporting_text: Heterodimerization of the epidermal-growth-factor 
            (EGF) receptor and ErbB2 and the affinity of EGF binding are 
            regulated by different mechanisms.
  - term:
      id: GO:0038134
      label: ERBB2-EGFR signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:22822073
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22822073
          supporting_text: 2012 Jul 20. Quantitation of the effect of ErbB2 on 
            epidermal growth factor receptor binding and dimerization.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: ISO
    original_reference_id: PMID:11336639
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11336639
          supporting_text: Heterodimerization of the epidermal-growth-factor 
            (EGF) receptor and ErbB2 and the affinity of EGF binding are 
            regulated by different mechanisms.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:22822073
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:22822073
          supporting_text: 2012 Jul 20. Quantitation of the effect of ErbB2 on 
            epidermal growth factor receptor binding and dimerization.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:6248866
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6248866
          supporting_text: Detection of epidermal growth factor-urogastrone and 
            its receptor during fetal mouse development.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:7752576
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7752576
          supporting_text: Tyrosine kinase activity of the EGF receptor in 
            murine metanephric organ culture.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:6248866
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6248866
          supporting_text: Detection of epidermal growth factor-urogastrone and 
            its receptor during fetal mouse development.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:7752576
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7752576
          supporting_text: Tyrosine kinase activity of the EGF receptor in 
            murine metanephric organ culture.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:16339969
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16339969
          supporting_text: Efficient suppression of FGF-2-induced ERK activation
            by the cooperative interaction among mammalian Sprouty isoforms.
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: IDA
    original_reference_id: PMID:9030684
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9030684
          supporting_text: Mutation in Sos1 dominantly enhances a weak allele of
            the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and
            development.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:8702723
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8702723
          supporting_text: The epidermal growth factor receptor couples 
            transforming growth factor-alpha, heparin-binding epidermal growth 
            factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
  - term:
      id: GO:0005154
      label: epidermal growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:7678348
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7678348
          supporting_text: Expression of the epidermal growth factor receptor 
            gene is regulated in mouse blastocysts during delayed implantation.
  - term:
      id: GO:0061098
      label: positive regulation of protein tyrosine kinase activity
    evidence_type: IDA
    original_reference_id: PMID:7678348
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7678348
          supporting_text: Expression of the epidermal growth factor receptor 
            gene is regulated in mouse blastocysts during delayed implantation.
  - term:
      id: GO:0050731
      label: positive regulation of peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:21186272
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21186272
          supporting_text: Activation of the neuregulin/ErbB system during 
            physiological ventricular remodeling in pregnancy.
  - term:
      id: GO:0043388
      label: positive regulation of DNA binding
    evidence_type: IDA
    original_reference_id: PMID:15156153
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15156153
          supporting_text: Hes binding to STAT3 mediates crosstalk between Notch
            and JAK-STAT signalling.
  - term:
      id: GO:0046425
      label: regulation of receptor signaling pathway via JAK-STAT
    evidence_type: IDA
    original_reference_id: PMID:15156153
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15156153
          supporting_text: Hes binding to STAT3 mediates crosstalk between Notch
            and JAK-STAT signalling.
  - term:
      id: GO:0090370
      label: negative regulation of cholesterol efflux
    evidence_type: IDA
    original_reference_id: PMID:20037141
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20037141
          supporting_text: 2009 Dec 25. Inhibition of ERK1/2 and activation of 
            liver X receptor synergistically induce macrophage ABCA1 expression 
            and cholesterol efflux.
  - term:
      id: GO:2000060
      label: positive regulation of ubiquitin-dependent protein catabolic 
        process
    evidence_type: IDA
    original_reference_id: PMID:20208556
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20208556
          supporting_text: Presenilin modulates EGFR signaling and cell 
            transformation by regulating the ubiquitin ligase Fbw7.
  - term:
      id: GO:0051223
      label: regulation of protein transport
    evidence_type: ISO
    original_reference_id: PMID:19723622
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19723622
          supporting_text: '2009 Sep 1. Activator of G protein signaling 8 (AGS8)
            is required for hypoxia-induced apoptosis of cardiomyocytes: role of G
            betagamma and connexin 43 (CX43).'
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:17626015
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17626015
          supporting_text: 2007 Jul 10. SGIP1alpha is an endocytic protein that 
            directly interacts with phospholipids and Eps15.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:17626015
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17626015
          supporting_text: 2007 Jul 10. SGIP1alpha is an endocytic protein that 
            directly interacts with phospholipids and Eps15.
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005154
      label: epidermal growth factor receptor binding
    evidence_type: IDA
    original_reference_id: PMID:6315706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6315706
          supporting_text: Epidermal growth factor-like transforming growth 
            factor.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:6315706
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6315706
          supporting_text: Epidermal growth factor-like transforming growth 
            factor.
  - term:
      id: GO:0060749
      label: mammary gland alveolus development
    evidence_type: IGI
    original_reference_id: PMID:10331984
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10331984
          supporting_text: Targeted inactivation of the EGF and amphiregulin 
            genes reveals distinct roles for EGF receptor ligands in mouse 
            mammary gland development.
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-179883
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-179883
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:7641815
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7641815
          supporting_text: Altering the expression of cell surface beta 
            1,4-galactosyltransferase modulates cell growth.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:7641815
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7641815
          supporting_text: Altering the expression of cell surface beta 
            1,4-galactosyltransferase modulates cell growth.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IGI
    original_reference_id: PMID:7641815
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7641815
          supporting_text: Altering the expression of cell surface beta 
            1,4-galactosyltransferase modulates cell growth.
  - term:
      id: GO:0021940
      label: positive regulation of cerebellar granule cell precursor 
        proliferation
    evidence_type: IDA
    original_reference_id: PMID:10027293
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10027293
          supporting_text: Control of neuronal precursor proliferation in the 
            cerebellum by Sonic Hedgehog.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IGI
    original_reference_id: PMID:15051883
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15051883
          supporting_text: Neuropoietin, a new IL-6-related cytokine signaling 
            through the ciliary neurotrophic factor receptor.
  - term:
      id: GO:0048754
      label: branching morphogenesis of an epithelial tube
    evidence_type: IDA
    original_reference_id: PMID:15831470
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15831470
          supporting_text: Integrin-linked kinase mediates bone morphogenetic 
            protein 7-dependent renal epithelial cell morphogenesis.
  - term:
      id: GO:0007173
      label: epidermal growth factor receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:15695332
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15695332
          supporting_text: Suppressor of cytokine signaling (SOCS)-5 is a 
            potential negative regulator of epidermal growth factor signaling.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:15695332
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15695332
          supporting_text: Suppressor of cytokine signaling (SOCS)-5 is a 
            potential negative regulator of epidermal growth factor signaling.
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IDA
    original_reference_id: PMID:14712229
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:14712229
          supporting_text: 'G-protein-coupled receptor-mediated activation of rap
            GTPases: characterization of a novel Galphai regulated pathway.'
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IGI
    original_reference_id: PMID:15509736
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15509736
          supporting_text: Fibroblast growth factor receptor signaling promotes 
            radial glial identity and interacts with Notch1 signaling in 
            telencephalic progenitors.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:8240367
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8240367
          supporting_text: An inborn error in epidermal growth factor prohormone
            metabolism in a mouse model of autosomal recessive polycystic kidney
            disease.
  - term:
      id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:14561752
    review:
      summary: >-
        OVER-ANNOTATION: EGF is a secreted growth factor ligand that does NOT perform
        phosphorylation itself. It binds to EGFR (EGF receptor), which is a receptor
        tyrosine kinase that performs the actual phosphorylation. PMID:14561752 shows
        that EGF stimulates tyrosine phosphorylation of catenins, but the kinase
        activity belongs to EGFR, not to EGF. The correct annotation for EGF should
        be GO:0050730 "regulation of peptidyl-tyrosine phosphorylation" (already
        annotated) or GO:0030297 "transmembrane receptor protein tyrosine kinase
        activator activity" (also already annotated).
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:14561752
          supporting_text: 2003 Oct 15. N-acetylglucosaminyltransferase V 
            expression levels regulate cadherin-associated homotypic cell-cell 
            adhesion and intracellular signaling pathways.
  - term:
      id: GO:0050730
      label: regulation of peptidyl-tyrosine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:11940581
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11940581
          supporting_text: 2002 Apr 8. Protein kinase C-alpha and protein kinase
            C-epsilon are required for Grb2-associated binder-1 tyrosine 
            phosphorylation in response to platelet-derived growth factor.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000008
    title: Gene Ontology annotation by the MGI curatorial staff, curated 
      orthology
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10027293
    title: Control of neuronal precursor proliferation in the cerebellum by 
      Sonic Hedgehog.
    findings: []
  - id: PMID:10331984
    title: Targeted inactivation of the EGF and amphiregulin genes reveals 
      distinct roles for EGF receptor ligands in mouse mammary gland 
      development.
    findings: []
  - id: PMID:11336639
    title: Heterodimerization of the epidermal-growth-factor (EGF) receptor and 
      ErbB2 and the affinity of EGF binding are regulated by different 
      mechanisms.
    findings: []
  - id: PMID:11823423
    title: A mutant EGF-receptor defective in ubiquitylation and endocytosis 
      unveils a role for Grb2 in negative signaling.
    findings: []
  - id: PMID:11940581
    title: Protein kinase C-alpha and protein kinase C-epsilon are required for 
      Grb2-associated binder-1 tyrosine phosphorylation in response to 
      platelet-derived growth factor.
    findings: []
  - id: PMID:12761849
    title: EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC 
      isozymes regulates branching morphogenesis of the fetal mouse 
      submandibular gland.
    findings: []
  - id: PMID:14561752
    title: N-acetylglucosaminyltransferase V expression levels regulate 
      cadherin-associated homotypic cell-cell adhesion and intracellular 
      signaling pathways.
    findings: []
  - id: PMID:14627991
    title: Serine mutations that abrogate ligand-induced ubiquitination and 
      internalization of the EGF receptor do not affect c-Cbl association with 
      the receptor.
    findings: []
  - id: PMID:14712229
    title: 'G-protein-coupled receptor-mediated activation of rap GTPases: characterization
      of a novel Galphai regulated pathway.'
    findings: []
  - id: PMID:15051883
    title: Neuropoietin, a new IL-6-related cytokine signaling through the 
      ciliary neurotrophic factor receptor.
    findings: []
  - id: PMID:15156153
    title: Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT 
      signalling.
    findings: []
  - id: PMID:15509736
    title: Fibroblast growth factor receptor signaling promotes radial glial 
      identity and interacts with Notch1 signaling in telencephalic progenitors.
    findings: []
  - id: PMID:15695332
    title: Suppressor of cytokine signaling (SOCS)-5 is a potential negative 
      regulator of epidermal growth factor signaling.
    findings: []
  - id: PMID:15831470
    title: Integrin-linked kinase mediates bone morphogenetic protein 
      7-dependent renal epithelial cell morphogenesis.
    findings: []
  - id: PMID:16339969
    title: Efficient suppression of FGF-2-induced ERK activation by the 
      cooperative interaction among mammalian Sprouty isoforms.
    findings: []
  - id: PMID:17626015
    title: SGIP1alpha is an endocytic protein that directly interacts with 
      phospholipids and Eps15.
    findings: []
  - id: PMID:19723622
    title: 'Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced
      apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).'
    findings: []
  - id: PMID:20037141
    title: Inhibition of ERK1/2 and activation of liver X receptor 
      synergistically induce macrophage ABCA1 expression and cholesterol efflux.
    findings: []
  - id: PMID:20208556
    title: Presenilin modulates EGFR signaling and cell transformation by 
      regulating the ubiquitin ligase Fbw7.
    findings: []
  - id: PMID:21186272
    title: Activation of the neuregulin/ErbB system during physiological 
      ventricular remodeling in pregnancy.
    findings: []
  - id: PMID:22822073
    title: Quantitation of the effect of ErbB2 on epidermal growth factor 
      receptor binding and dimerization.
    findings: []
  - id: PMID:6248866
    title: Detection of epidermal growth factor-urogastrone and its receptor 
      during fetal mouse development.
    findings: []
  - id: PMID:6315706
    title: Epidermal growth factor-like transforming growth factor. II. 
      Interaction with epidermal growth factor receptors in human placenta 
      membranes and A431 cells.
    findings: []
  - id: PMID:7641815
    title: Altering the expression of cell surface beta 
      1,4-galactosyltransferase modulates cell growth.
    findings: []
  - id: PMID:7678348
    title: Expression of the epidermal growth factor receptor gene is regulated 
      in mouse blastocysts during delayed implantation.
    findings: []
  - id: PMID:7752576
    title: Tyrosine kinase activity of the EGF receptor in murine metanephric 
      organ culture.
    findings: []
  - id: PMID:8240367
    title: An inborn error in epidermal growth factor prohormone metabolism in a
      mouse model of autosomal recessive polycystic kidney disease.
    findings: []
  - id: PMID:8702723
    title: The epidermal growth factor receptor couples transforming growth 
      factor-alpha, heparin-binding epidermal growth factor-like factor, and 
      amphiregulin to Neu, ErbB-3, and ErbB-4.
    findings: []
  - id: PMID:9030684
    title: Mutation in Sos1 dominantly enhances a weak allele of the EGFR, 
      demonstrating a requirement for Sos1 in EGFR signaling and development.
    findings: []
  - id: PMID:9529375
    title: Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse
      embryonic fibroblasts.
    findings: []
  - id: Reactome:R-MMU-179883
    title: Mouse pro-EGF is cleaved by ADAM sheddases
    findings: []