Epo

UniProt ID: P07321
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Epo

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005128 erythropoietin receptor binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005179 hormone activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030218 erythrocyte differentiation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030295 protein kinase activator activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038162 erythropoietin-mediated signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097696 cell surface receptor signaling pathway via STAT
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005125 cytokine activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005128 erythropoietin receptor binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005179 hormone activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006950 response to stress
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043249 erythrocyte maturation
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005125 cytokine activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005128 erythropoietin receptor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005179 hormone activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009986 cell surface
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010523 negative regulation of calcium ion transport into cytosol
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030218 erythrocyte differentiation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038162 erythropoietin-mediated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046579 positive regulation of Ras protein signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071474 cellular hyperosmotic response
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097696 cell surface receptor signaling pathway via STAT
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902251 negative regulation of erythrocyte apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001666 response to hypoxia
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005125 cytokine activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006953 acute-phase response
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007584 response to nutrient
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009651 response to salt stress
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009986 cell surface
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010523 negative regulation of calcium ion transport into cytosol
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010976 positive regulation of neuron projection development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030218 erythrocyte differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032496 response to lipopolysaccharide
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033189 response to vitamin A
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033574 response to testosterone
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038162 erythropoietin-mediated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042104 positive regulation of activated T cell proliferation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043627 response to estrogen
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044297 cell body
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045666 positive regulation of neuron differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046579 positive regulation of Ras protein signal transduction
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048678 response to axon injury
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051602 response to electrical stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0055093 response to hyperoxia
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070555 response to interleukin-1
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071474 cellular hyperosmotic response
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071548 response to dexamethasone
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097696 cell surface receptor signaling pathway via STAT
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1902251 negative regulation of erythrocyte apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010976 positive regulation of neuron projection development
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042104 positive regulation of activated T cell proliferation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0044297 cell body
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045666 positive regulation of neuron differentiation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9006326 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9006327 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9006329 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9012652 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9012653 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9012656 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9027266 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9027268 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9027429 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9027436 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9029146 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9029147 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9029152 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9029162 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9030346 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9030353 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-9032476 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005128 erythropoietin receptor binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0038162 erythropoietin-mediated signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033033 negative regulation of myeloid cell apoptotic process
IDA
PMID:17981124
SUMO-specific protease 1 is essential for stabilization of H... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17981124
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
GO:0018105 peptidyl-serine phosphorylation
IDA
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by ery... 		MODIFY
Summary: OVER-ANNOTATION: Erythropoietin (Epo) is a secreted cytokine/hormone that does NOT perform phosphorylation itself. PMID:21095239 shows "Epo-activated JNK1 phosphorylated Bad at threonine 201" - the phosphorylation is performed by JNK1, not Epo. Epo binds EPOR and activates JAK2 which then activates downstream kinases. The correct annotations are GO:0030295 "protein kinase activator activity" and GO:0045860 "positive regulation of protein kinase activity" (both already annotated from the same PMID).
Supporting Evidence:
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
GO:0030295 protein kinase activator activity
IDA
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by ery... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
GO:0043066 negative regulation of apoptotic process
IDA
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by ery... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
GO:0045860 positive regulation of protein kinase activity
IDA
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by ery... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
GO:0005128 erythropoietin receptor binding
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0001525 angiogenesis
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0003007 heart morphogenesis
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0055008 cardiac muscle tissue morphogenesis
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0055010 ventricular cardiac muscle tissue morphogenesis
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0061032 visceral serous pericardium development
TAS
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculoge... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
GO:0006357 regulation of transcription by RNA polymerase II
IDA
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglob... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.
GO:0006915 apoptotic process
IDA
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglob... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.
GO:0007566 embryo implantation
IDA
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglob... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.
GO:0042541 hemoglobin biosynthetic process
IDA
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglob... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.
GO:0030218 erythrocyte differentiation
IDA
PMID:15591122
BMP4 and Madh5 regulate the erythroid response to acute anem... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15591122
Dec 9. BMP4 and Madh5 regulate the erythroid response to acute anemia.
GO:0001666 response to hypoxia
IDA
PMID:15016652
Superoxide dismutase-3 promotes full expression of the EPO r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15016652
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
GO:0005615 extracellular space
IDA
PMID:15016652
Superoxide dismutase-3 promotes full expression of the EPO r... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15016652
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.

References

GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:15016652
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
PMID:15591122
BMP4 and Madh5 regulate the erythroid response to acute anemia.
PMID:17300687
Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.
PMID:17981124
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
PMID:20299672
Epicardial-myocardial signaling directing coronary vasculogenesis.
PMID:21095239
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
Reactome:R-MMU-9006326
Epo binds Epor:Jak2:Lyn:Irs2
Reactome:R-MMU-9006327
Phospho-Jak2 phosphorylates Epor
Reactome:R-MMU-9006329
Jak2 transphosphorylates and is activated in response to Erythropoietin
Reactome:R-MMU-9012652
p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2
Reactome:R-MMU-9012653
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5
Reactome:R-MMU-9012656
phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5
Reactome:R-MMU-9027266
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1
Reactome:R-MMU-9027268
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k
Reactome:R-MMU-9027429
Lyn phosphorylates Plcg1,2 in Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2
Reactome:R-MMU-9027436
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2
Reactome:R-MMU-9029146
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1
Reactome:R-MMU-9029147
Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1
Reactome:R-MMU-9029152
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras
Reactome:R-MMU-9029162
Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1
Reactome:R-MMU-9030346
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1
Reactome:R-MMU-9030353
Lyn phosphorylates Crkl in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Crkl:Rapgef1
Reactome:R-MMU-9032476
Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

📄 View Raw YAML

 
id: P07321
gene_symbol: Epo
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Epo'
existing_annotations:
  - term:
      id: GO:0005128
      label: erythropoietin receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030218
      label: erythrocyte differentiation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030295
      label: protein kinase activator activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038162
      label: erythropoietin-mediated signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097696
      label: cell surface receptor signaling pathway via STAT
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005125
      label: cytokine activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005128
      label: erythropoietin receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006950
      label: response to stress
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043249
      label: erythrocyte maturation
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005125
      label: cytokine activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005128
      label: erythropoietin receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005179
      label: hormone activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010523
      label: negative regulation of calcium ion transport into cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030218
      label: erythrocyte differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038162
      label: erythropoietin-mediated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046579
      label: positive regulation of Ras protein signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071474
      label: cellular hyperosmotic response
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097696
      label: cell surface receptor signaling pathway via STAT
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902219
      label: negative regulation of intrinsic apoptotic signaling pathway in 
        response to osmotic stress
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902251
      label: negative regulation of erythrocyte apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000122
      label: negative regulation of transcription by RNA polymerase II
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005125
      label: cytokine activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006953
      label: acute-phase response
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007584
      label: response to nutrient
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009651
      label: response to salt stress
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010523
      label: negative regulation of calcium ion transport into cytosol
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010976
      label: positive regulation of neuron projection development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030218
      label: erythrocyte differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032496
      label: response to lipopolysaccharide
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033189
      label: response to vitamin A
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033574
      label: response to testosterone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038162
      label: erythropoietin-mediated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042104
      label: positive regulation of activated T cell proliferation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043627
      label: response to estrogen
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044297
      label: cell body
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045666
      label: positive regulation of neuron differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045893
      label: positive regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046579
      label: positive regulation of Ras protein signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048678
      label: response to axon injury
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051602
      label: response to electrical stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0055093
      label: response to hyperoxia
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070555
      label: response to interleukin-1
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071474
      label: cellular hyperosmotic response
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071548
      label: response to dexamethasone
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097696
      label: cell surface receptor signaling pathway via STAT
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902219
      label: negative regulation of intrinsic apoptotic signaling pathway in 
        response to osmotic stress
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1902251
      label: negative regulation of erythrocyte apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010976
      label: positive regulation of neuron projection development
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042104
      label: positive regulation of activated T cell proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0044297
      label: cell body
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045666
      label: positive regulation of neuron differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043161
      label: proteasome-mediated ubiquitin-dependent protein catabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9006326
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9006327
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9006329
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9012652
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9012653
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9012656
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9027266
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9027268
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9027429
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9027436
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9029146
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9029147
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9029152
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9029162
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9030346
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9030353
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-9032476
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005128
      label: erythropoietin receptor binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0038162
      label: erythropoietin-mediated signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0033033
      label: negative regulation of myeloid cell apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:17981124
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17981124
          supporting_text: SUMO-specific protease 1 is essential for 
            stabilization of HIF1alpha during hypoxia.
  - term:
      id: GO:0018105
      label: peptidyl-serine phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:21095239
    review:
      summary: >-
        OVER-ANNOTATION: Erythropoietin (Epo) is a secreted cytokine/hormone that
        does
        NOT perform phosphorylation itself. PMID:21095239 shows "Epo-activated JNK1
        phosphorylated Bad at threonine 201" - the phosphorylation is performed by
        JNK1,
        not Epo. Epo binds EPOR and activates JAK2 which then activates downstream
        kinases.
        The correct annotations are GO:0030295 "protein kinase activator activity"
        and
        GO:0045860 "positive regulation of protein kinase activity" (both already
        annotated
        from the same PMID).
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:21095239
          supporting_text: Phosphorylation of Bcl-associated death protein (Bad)
            by erythropoietin-activated c-Jun N-terminal protein kinase 1 
            contributes to survival of erythropoietin-dependent cells.
  - term:
      id: GO:0030295
      label: protein kinase activator activity
    evidence_type: IDA
    original_reference_id: PMID:21095239
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21095239
          supporting_text: Phosphorylation of Bcl-associated death protein (Bad)
            by erythropoietin-activated c-Jun N-terminal protein kinase 1 
            contributes to survival of erythropoietin-dependent cells.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:21095239
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21095239
          supporting_text: Phosphorylation of Bcl-associated death protein (Bad)
            by erythropoietin-activated c-Jun N-terminal protein kinase 1 
            contributes to survival of erythropoietin-dependent cells.
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: IDA
    original_reference_id: PMID:21095239
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21095239
          supporting_text: Phosphorylation of Bcl-associated death protein (Bad)
            by erythropoietin-activated c-Jun N-terminal protein kinase 1 
            contributes to survival of erythropoietin-dependent cells.
  - term:
      id: GO:0005128
      label: erythropoietin receptor binding
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0001525
      label: angiogenesis
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0003007
      label: heart morphogenesis
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0055008
      label: cardiac muscle tissue morphogenesis
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0055010
      label: ventricular cardiac muscle tissue morphogenesis
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0060979
      label: vasculogenesis involved in coronary vascular morphogenesis
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0061032
      label: visceral serous pericardium development
    evidence_type: TAS
    original_reference_id: PMID:20299672
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20299672
          supporting_text: Epicardial-myocardial signaling directing coronary 
            vasculogenesis.
  - term:
      id: GO:0006357
      label: regulation of transcription by RNA polymerase II
    evidence_type: IDA
    original_reference_id: PMID:17300687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17300687
          supporting_text: 'Erythropoietin contributes to implantation: ectopic hemoglobin
            synthesis in decidual cells of mice.'
  - term:
      id: GO:0006915
      label: apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:17300687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17300687
          supporting_text: 'Erythropoietin contributes to implantation: ectopic hemoglobin
            synthesis in decidual cells of mice.'
  - term:
      id: GO:0007566
      label: embryo implantation
    evidence_type: IDA
    original_reference_id: PMID:17300687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17300687
          supporting_text: 'Erythropoietin contributes to implantation: ectopic hemoglobin
            synthesis in decidual cells of mice.'
  - term:
      id: GO:0042541
      label: hemoglobin biosynthetic process
    evidence_type: IDA
    original_reference_id: PMID:17300687
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:17300687
          supporting_text: 'Erythropoietin contributes to implantation: ectopic hemoglobin
            synthesis in decidual cells of mice.'
  - term:
      id: GO:0030218
      label: erythrocyte differentiation
    evidence_type: IDA
    original_reference_id: PMID:15591122
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15591122
          supporting_text: Dec 9. BMP4 and Madh5 regulate the erythroid response
            to acute anemia.
  - term:
      id: GO:0001666
      label: response to hypoxia
    evidence_type: IDA
    original_reference_id: PMID:15016652
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15016652
          supporting_text: Superoxide dismutase-3 promotes full expression of 
            the EPO response to hypoxia.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:15016652
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15016652
          supporting_text: Superoxide dismutase-3 promotes full expression of 
            the EPO response to hypoxia.
references:
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:15016652
    title: Superoxide dismutase-3 promotes full expression of the EPO response 
      to hypoxia.
    findings: []
  - id: PMID:15591122
    title: BMP4 and Madh5 regulate the erythroid response to acute anemia.
    findings: []
  - id: PMID:17300687
    title: 'Erythropoietin contributes to implantation: ectopic hemoglobin synthesis
      in decidual cells of mice.'
    findings: []
  - id: PMID:17981124
    title: SUMO-specific protease 1 is essential for stabilization of HIF1alpha 
      during hypoxia.
    findings: []
  - id: PMID:20299672
    title: Epicardial-myocardial signaling directing coronary vasculogenesis.
    findings: []
  - id: PMID:21095239
    title: Phosphorylation of Bcl-associated death protein (Bad) by 
      erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to 
      survival of erythropoietin-dependent cells.
    findings: []
  - id: Reactome:R-MMU-9006326
    title: Epo binds Epor:Jak2:Lyn:Irs2
    findings: []
  - id: Reactome:R-MMU-9006327
    title: Phospho-Jak2 phosphorylates Epor
    findings: []
  - id: Reactome:R-MMU-9006329
    title: Jak2 transphosphorylates and is activated in response to 
      Erythropoietin
    findings: []
  - id: Reactome:R-MMU-9012652
    title: p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2
    findings: []
  - id: Reactome:R-MMU-9012653
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5
    findings: []
  - id: Reactome:R-MMU-9012656
    title: phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5
    findings: []
  - id: Reactome:R-MMU-9027266
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1
    findings: []
  - id: Reactome:R-MMU-9027268
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k
    findings: []
  - id: Reactome:R-MMU-9027429
    title: Lyn phosphorylates Plcg1,2 in 
      Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2
    findings: []
  - id: Reactome:R-MMU-9027436
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2
    findings: []
  - id: Reactome:R-MMU-9029146
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds 
      Grb2-1:Sos1
    findings: []
  - id: Reactome:R-MMU-9029147
    title: Jak2 phosphorylates Shc1 in 
      Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1
    findings: []
  - id: Reactome:R-MMU-9029152
    title: 
      Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 
      mediates exchange of GDP for GTP bound to Ras
    findings: []
  - id: Reactome:R-MMU-9029162
    title: Jak2 phosphorylates Vav1 in 
      Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1
    findings: []
  - id: Reactome:R-MMU-9030346
    title: Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1
    findings: []
  - id: Reactome:R-MMU-9030353
    title: Lyn phosphorylates Crkl in 
      Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Crkl:Rapgef1
    findings: []
  - id: Reactome:R-MMU-9032476
    title: Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 
      4,5-bisphosphate
    findings: []