Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005886 plasma membrane	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0030154 cell differentiation	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0050852 T cell receptor signaling pathway	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding	IEA GO_REF:0000002	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0043204 perikaryon	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:10077576 Characterization of Sam68-like mammalian proteins SLM-1 and ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is invol...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:15102471 Bioinformatics and cellular signaling.	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16316995 IgE-dependent activation of sphingosine kinases 1 and 2 and ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:16847311 Association between SAP and FynT: Inducible SH3 domain-media...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:25417160 A noncanonical Frizzled2 pathway regulates epithelial-mesenc...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:27474268 Co-recruitment analysis of the CBL and CBLB signalosomes in ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:7730365 Sequence requirements for binding of Src family tyrosine kin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:8631859 The Fyn tyrosine kinase binds Irs-1 and forms a distinct sig...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9535845 Physical and functional interactions between receptor-like p...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9890970 Fyn associates with Cbl and phosphorylates tyrosine 731 in C...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000304 response to singlet oxygen	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0001664 G protein-coupled receptor binding	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0003015 heart process	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005768 endosome	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0007216 G protein-coupled glutamate receptor signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0009410 response to xenobiotic stimulus	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0016004 phospholipase activator activity	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0030101 natural killer cell activation	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0030425 dendrite	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0031802 type 5 metabotropic glutamate receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IEA GO_REF:0000120	PENDING	Summary: TODO: Review this GOA annotation
GO:0042220 response to cocaine	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0042608 T cell receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0042609 CD4 receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0042610 CD8 receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043274 phospholipase binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043524 negative regulation of neuron apoptotic process	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0043548 phosphatidylinositol 3-kinase binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0045121 membrane raft	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0050852 T cell receptor signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0051428 peptide hormone receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0070301 cellular response to hydrogen peroxide	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0070851 growth factor receptor binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0071363 cellular response to growth factor stimulus	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0071375 cellular response to peptide hormone stimulus	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0097038 perinuclear endoplasmic reticulum	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0097718 disordered domain specific binding	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0099092 postsynaptic density, intracellular component	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1904646 cellular response to amyloid-beta	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1905232 cellular response to L-glutamate	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:1905430 cellular response to glycine	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA GO_REF:0000107	PENDING	Summary: TODO: Review this GOA annotation
GO:0003015 heart process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005768 endosome	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0007216 G protein-coupled glutamate receptor signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0016004 phospholipase activator activity	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0030101 natural killer cell activation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0030425 dendrite	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043274 phospholipase binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045121 membrane raft	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0046875 ephrin receptor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0050852 T cell receptor signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070851 growth factor receptor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0097110 scaffold protein binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0097718 disordered domain specific binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1904646 cellular response to amyloid-beta	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0046777 protein autophosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0000304 response to singlet oxygen	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0019899 enzyme binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0030425 dendrite	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0031802 type 5 metabotropic glutamate receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0042608 T cell receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0042609 CD4 receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0042610 CD8 receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0043524 negative regulation of neuron apoptotic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0043548 phosphatidylinositol 3-kinase binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051428 peptide hormone receptor binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0070301 cellular response to hydrogen peroxide	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0097038 perinuclear endoplasmic reticulum	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0099092 postsynaptic density, intracellular component	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1905232 cellular response to L-glutamate	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1905430 cellular response to glycine	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9507006 Identification of sirm, a novel insulin-regulated SH3 bindin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0050860 negative regulation of T cell receptor signaling pathway	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0050868 negative regulation of T cell activation	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IMP PMID:27525436 Tyrosine kinase FYN negatively regulates NOX4 in cardiac rem...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035556 intracellular signal transduction	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:1900449 regulation of glutamate receptor signaling pathway	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	EXP PMID:16709819 Regulation of Ly49D/DAP12 signal transduction by Src-family ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-3928613	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9763891	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-983702	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-NUL-420398	PENDING	Summary: TODO: Review this GOA annotation
GO:0016525 negative regulation of angiogenesis	IMP PMID:10613822 Signals leading to apoptosis-dependent inhibition of neovasc...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:12526739 Fyn tyrosine kinase is a critical regulator of disabled-1 du...	PENDING	Summary: TODO: Review this GOA annotation
GO:0038026 reelin-mediated signaling pathway	IDA PMID:12526739 Fyn tyrosine kinase is a critical regulator of disabled-1 du...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050804 modulation of chemical synaptic transmission	IMP PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050804 modulation of chemical synaptic transmission	IDA PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	PENDING	Summary: TODO: Review this GOA annotation
GO:0098685 Schaffer collateral - CA1 synapse	IMP PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	PENDING	Summary: TODO: Review this GOA annotation
GO:0098685 Schaffer collateral - CA1 synapse	IDA PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	PENDING	Summary: TODO: Review this GOA annotation
GO:0010467 gene expression	IGI PMID:31461442 A bigenic mouse model of FSGS reveals perturbed pathways in ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	PENDING	Summary: TODO: Review this GOA annotation
GO:0090314 positive regulation of protein targeting to membrane	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:1902951 negative regulation of dendritic spine maintenance	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:1904645 response to amyloid-beta	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:1905664 regulation of calcium ion import across plasma membrane	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	IDA PMID:10557075 wt p53 dependent expression of a membrane-associated isoform...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0043014 alpha-tubulin binding	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048156 tau protein binding	IPI PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:12681493 Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:12681493 Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:26901312 A Central Nervous System-Dependent Intron-Embedded Gene Enco...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:26901312 A Central Nervous System-Dependent Intron-Embedded Gene Enco...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:22685302 Down syndrome cell adhesion molecule (DSCAM) associates with...	PENDING	Summary: TODO: Review this GOA annotation
GO:0003015 heart process	IGI PMID:27525436 Tyrosine kinase FYN negatively regulates NOX4 in cardiac rem...	PENDING	Summary: TODO: Review this GOA annotation
GO:0044297 cell body	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045121 membrane raft	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0097386 glial cell projection	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-1433273	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-2395436	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-3928613	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-3928635	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9605258	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9680646	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9680706	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682158	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682182	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9682572	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763891	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763892	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9763903	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9764150	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9817994	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-9818009	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-983702	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-420388	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-420398	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-421136	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-421138	PENDING	Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane	TAS Reactome:R-MMU-9032771	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0014069 postsynaptic density	IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0030425 dendrite	IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:8551236 Association of tyrosine protein kinase Zap-70 with the proto...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:24627473 Phosphorylation of the antiviral protein interferon-inducibl...	PENDING	Summary: TODO: Review this GOA annotation
GO:0031397 negative regulation of protein ubiquitination	IDA PMID:24627473 Phosphorylation of the antiviral protein interferon-inducibl...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071560 cellular response to transforming growth factor beta stimulus	IGI PMID:21829547 Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005768 endosome	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005884 actin filament	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0036120 cellular response to platelet-derived growth factor stimulus	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0071944 cell periphery	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IGI PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	PENDING	Summary: TODO: Review this GOA annotation
GO:0001664 G protein-coupled receptor binding	IPI PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	PENDING	Summary: TODO: Review this GOA annotation
GO:1900182 positive regulation of protein localization to nucleus	IMP PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:11711534 'Srcasm: a novel Src activating and signaling molecule.	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	PENDING	Summary: TODO: Review this GOA annotation
GO:1900182 positive regulation of protein localization to nucleus	IDA PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein	IMP PMID:23438599 Fyn regulates adipogenesis by promoting PIKE-A/STAT5a intera...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9185665 Molecular cloning of Fyn-associated molecules in the mouse c...	PENDING	Summary: TODO: Review this GOA annotation
GO:0010976 positive regulation of neuron projection development	IGI PMID:18354028 Voltage-gated Na+ channel beta1 subunit-mediated neurite out...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9655502 Diversity revealed by a novel family of cadherins expressed ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048813 dendrite morphogenesis	IMP PMID:12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is invol...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IMP PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	PENDING	Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway	IDA PMID:9177270 Mouse CD24 as a signaling molecule for integrin-mediated cel...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008360 regulation of cell shape	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0044325 transmembrane transporter binding	IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b...	PENDING	Summary: TODO: Review this GOA annotation
GO:0010629 negative regulation of gene expression	IMP PMID:20978343 CD36 participates in a signaling pathway that regulates ROS ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:16841086 Src-family tyrosine kinase fyn phosphorylates phosphatidylin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042177 negative regulation of protein catabolic process	IMP PMID:16841086 Src-family tyrosine kinase fyn phosphorylates phosphatidylin...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-420382	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-MMU-420394	PENDING	Summary: TODO: Review this GOA annotation
GO:0005829 cytosol	TAS Reactome:R-NUL-420386	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:7799925 Association of p62, a multifunctional SH2- and SH3-domain-bi...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IMP PMID:9381182 Fyn-kinase as a determinant of ethanol sensitivity: relation...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045471 response to ethanol	IGI PMID:9381182 Fyn-kinase as a determinant of ethanol sensitivity: relation...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0046777 protein autophosphorylation	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050798 activated T cell proliferation	IMP PMID:1516132 Defective T cell receptor signaling in mice lacking the thym...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation	IMP PMID:16190898 Fyn kinase-mediated phosphorylation of NMDA receptor NR2B su...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation	IMP PMID:9892651 PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain	IMP PMID:16190898 Fyn kinase-mediated phosphorylation of NMDA receptor NR2B su...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:10713104 HS1 interacts with Lyn and is critical for erythropoietin-in...	PENDING	Summary: TODO: Review this GOA annotation
GO:0001764 neuron migration	IMP PMID:15073522 Defective neocortical development in Fyn-tyrosine-kinase-def...	PENDING	Summary: TODO: Review this GOA annotation
GO:0030900 forebrain development	IMP PMID:15073522 Defective neocortical development in Fyn-tyrosine-kinase-def...	PENDING	Summary: TODO: Review this GOA annotation
GO:0001764 neuron migration	IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype.	PENDING	Summary: TODO: Review this GOA annotation
GO:0030900 forebrain development	IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype.	PENDING	Summary: TODO: Review this GOA annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0004672 protein kinase activity	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0015631 tubulin binding	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042552 myelination	TAS PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	PENDING	Summary: TODO: Review this GOA annotation

References

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000096

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000119

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10077576

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.

PMID:10557075

wt p53 dependent expression of a membrane-associated isoform of adenylate kinase.

PMID:10613822

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

PMID:10713104

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.

PMID:10872802

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.

PMID:11711534

'Srcasm: a novel Src activating and signaling molecule.

PMID:11826099

Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.

PMID:12372285

Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.

PMID:12526739

Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.

PMID:12538589

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

PMID:12681493

Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells.

PMID:1361685

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

PMID:15073522

Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.

PMID:15102471

Bioinformatics and cellular signaling.

PMID:1516132

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.

PMID:16162939

Absence of Fyn and Src causes a reeler-like phenotype.

PMID:16190898

Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.

PMID:16316995

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.

PMID:16709819

Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.

PMID:16841086

Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.

PMID:16847311

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.

PMID:17623777

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

PMID:17923684

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.

PMID:18354028

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.

PMID:20142099

Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.

PMID:20655099

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

PMID:20978343

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.

PMID:21829547

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

PMID:22685302

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PMID:22820466

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

PMID:23169819

GPRC5B activates obesity-associated inflammatory signaling in adipocytes.

PMID:23438599

Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

PMID:24627473

Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination.

PMID:25417160

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

PMID:26901312

A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine Fyn Binding Protein.

PMID:27474268

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.

PMID:27525436

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.

PMID:28598420

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.

PMID:31461442

A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells.

PMID:7730365

Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors.

PMID:7799925

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.

PMID:8175795

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

PMID:8196616

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.

PMID:8551236

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

PMID:8631859

The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.

PMID:9177270

Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases.

PMID:9185665

Molecular cloning of Fyn-associated molecules in the mouse central nervous system.

PMID:9381182

Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.

PMID:9507006

Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.

PMID:9535845

Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.

PMID:9655502

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PMID:9890970

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.

PMID:9892651

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

Reactome:R-MMU-1433273

Interaction of Src kinases with c-Kit

Reactome:R-MMU-2395436

Phosphorylation of DAP12

Reactome:R-MMU-3928613

Fyn phosphorylates Nmdar2b

Reactome:R-MMU-3928635

Ephb2 bind Nmdar

Reactome:R-MMU-420382

Phosphorylation of FAK by Src kinases

Reactome:R-MMU-420394

Recruitment of FAK to NCAM1:Fyn in lipid rafts

Reactome:R-MMU-9032771

Dock3 binds Fyn associated with Ntrk2

Reactome:R-MMU-9605258

Active Flt3 binds Fyn

Reactome:R-MMU-9680646

Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated

Reactome:R-MMU-9680706

Csf1r trans-autophosphorylates on multiple tyrosine residues

Reactome:R-MMU-9682158

Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Reactome:R-MMU-9682182

Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Reactome:R-MMU-9682572

Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Reactome:R-MMU-9763891

Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl

Reactome:R-MMU-9763892

p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12

Reactome:R-MMU-9763903

Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Reactome:R-MMU-9764150

Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1

Reactome:R-MMU-9817994

Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

Reactome:R-MMU-9818009

Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1

Reactome:R-MMU-983702

Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)

Reactome:R-NUL-420386

Fyn binds NCAM1

Reactome:R-NUL-420388

Dephosphorylation of NCAM1 bound pFyn

Reactome:R-NUL-420398

Autophosphorylation of NCAM1 bound Fyn

Reactome:R-NUL-421136

Recruitment and activation of Cdk5

Reactome:R-NUL-421138

Activation of Fyn

📚 Additional Documentation

Deep Research Bioreason

(Fyn-deep-research-bioreason.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:30 AM

Organism: Mus musculus

Sequence:

MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Thinking Trace

I begin by dissecting the InterPro architecture and its order along the polypeptide. The N-terminal third contains IPR036028 (SH3-like domain superfamily, residues 68–195) with a discrete IPR001452 SH3 domain (residues 82–143) refined by the lineage-specific IPR035750 Fyn/Yrk SH3 domain (residues 85–140). Immediately downstream sits the SH2 module ensemble: IPR036860 SH2 domain superfamily (residues 140–291), IPR047924 Fyn/Yrk SH2 domain (residues 145–245), and the canonical IPR000980 SH2 domain (residues 147–246). The C-terminal half transitions into the catalytic core: IPR011009 protein kinase-like domain superfamily (residues 258–528) and the folded bilobal kinase engine defined by IPR000719 protein kinase domain (residues 271–524), IPR001245 serine-threonine/tyrosine-protein kinase catalytic domain (residues 271–518), and IPR020635 tyrosine-protein kinase catalytic domain (residues 271–520). Within this engine, IPR017441 marks the ATP-binding site (residues 277–299), and IPR008266 annotates the tyrosine-kinase active site (residues 386–398). The overall architecture is capped by IPR050198 non-receptor tyrosine kinases involved in cell signaling (family, residues 88–531), which ties the SH3–SH2–kinase triad into a signaling-competent enzyme typical of Src-family kinases.

This ordered SH3–SH2–kinase arrangement dictates molecular function. The SH3 domain binds proline-rich motifs, positioning substrates or adaptors. The SH2 domain binds phosphotyrosine motifs, docking the enzyme onto activated receptors and scaffolds. The C-terminal kinase domain—equipped with a defined ATP-binding pocket and a tyrosine-kinase catalytic loop—causes phosphorylation of tyrosine residues. Therefore, the molecular function necessarily includes protein tyrosine kinase activity and ATP binding, and is reinforced by multivalent protein binding mediated by SH3 and SH2. The combination of IPR000719/IPR001245/IPR020635 together with the ATP-binding and catalytic motifs compels a precise enzymatic identity: a non-receptor tyrosine kinase that transfers the γ-phosphate of ATP to tyrosyl residues.

From this chemistry, the biological process follows. Tyrosine phosphorylation is a central switch in signal transduction cascades. The presence of the SH3–SH2 targeting modules upstream of a robust catalytic core positions the enzyme as a driver of intracellular signal transduction. Such kinases regulate adhesion, cytoskeletal remodeling, and survival pathways; thus they operate broadly within signal transduction and intracellular signal transduction, coordinating downstream effectors once tyrosine residues are primed by SH2-mediated docking.

Cellular location is inferred from both the soluble modular architecture and the typical membrane-proximal role of Src-family kinases. The absence of transmembrane segments and the soluble nature of SH3/SH2/kinase modules support a cytoplasmic enzyme that samples membrane-associated complexes via transient interactions. This aligns with a cytoplasmic residency, where membrane-proximal scaffolds and receptors are surveyed.

Mechanistically, the SH3 and SH2 domains assemble a targeting hub that recruits proline-rich adaptors and phosphotyrosine-bearing complexes. This targeting funnels substrates into the catalytic cleft, where ATP binding (residues 277–299) primes the active site to phosphorylate tyrosine residues via the conserved catalytic loop (residues 386–398). I hypothesize that this kinase transiently associates with membrane-proximal scaffolds and receptors—such as focal adhesion and immune-receptor assemblies—where SH2/SH3-guided docking concentrates it on activated signaling platforms. Likely partners include proline-rich adaptors and phosphotyrosine-rich scaffolds that nucleate pathways controlling adhesion and cytoskeletal dynamics. Together, the SH3–SH2–kinase architecture explains how this cytoplasmic enzyme executes tyrosine phosphorylation to propagate intracellular signaling.

Functional Summary

A cytoplasmic, non-receptor tyrosine kinase that uses SH3- and SH2-mediated docking to assemble on membrane-proximal signaling complexes and phosphorylate tyrosine residues via a conserved catalytic core. By coupling high-affinity substrate targeting with ATP-fueled catalysis, it propagates intracellular signaling pathways that regulate adhesion, cytoskeletal remodeling, and survival decisions in mouse cells.

UniProt Summary

Probable receptor tyrosine kinase.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 68-195
SH3 domain (IPR001452, domain) — residues 82-143
Fyn/Yrk, SH3 domain (IPR035750, domain) — residues 85-140
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 88-531
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-291
Fyn/Yrk, SH2 domain (IPR047924, domain) — residues 145-245
SH2 domain (IPR000980, domain) — residues 147-246
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Protein kinase domain (IPR000719, domain) — residues 271-524
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 271-518
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 271-520
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 277-299
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 386-398

GO Terms

Molecular Function: molecular_function (GO:0003674), binding (GO:0005488), catalytic activity (GO:0003824), transferase activity (GO:0016740), catalytic activity, acting on a protein (GO:0140096), protein binding (GO:0005515), signaling receptor binding (GO:0005102), transferase activity, transferring phosphorus-containing groups (GO:0016772), protein kinase activity (GO:0004672), transmembrane transporter binding (GO:0044325), cytoskeletal protein binding (GO:0008092), kinase activity (GO:0016301), phosphotransferase activity, alcohol group as acceptor (GO:0016773), protein tyrosine kinase activity (GO:0004713), G protein-coupled receptor binding (GO:0001664), tau protein binding (GO:0048156), tubulin binding (GO:0015631), alpha-tubulin binding (GO:0043014)

Biological Process: biological_process (GO:0008150), positive regulation of biological process (GO:0048518), regulation of biological process (GO:0050789), signaling (GO:0023052), multicellular organismal process (GO:0032501), biological regulation (GO:0065007), response to stimulus (GO:0050896), developmental process (GO:0032502), cellular process (GO:0009987), metabolic process (GO:0008152), immune system process (GO:0002376), negative regulation of biological process (GO:0048519), response to external stimulus (GO:0009605), anatomical structure development (GO:0048856), anatomical structure morphogenesis (GO:0009653), cell motility (GO:0048870), response to chemical (GO:0042221), leukocyte activation (GO:0045321), cell population proliferation (GO:0008283), nitrogen compound metabolic process (GO:0006807), cellular component organization or biogenesis (GO:0071840), ensheathment of neurons (GO:0007272), positive regulation of transport (GO:0051050), negative regulation of metabolic process (GO:0009892), regulation of developmental process (GO:0050793), regulation of biological quality (GO:0065008), response to endogenous stimulus (GO:0009719), regulation of cellular process (GO:0050794), regulation of response to stimulus (GO:0048583), cellular response to stimulus (GO:0051716), regulation of signaling (GO:0023051), negative regulation of cellular process (GO:0048523), signal transduction (GO:0007165), cellular developmental process (GO:0048869), response to abiotic stimulus (GO:0009628), positive regulation of signaling (GO:0023056), cell activation (GO:0001775), multicellular organism development (GO:0007275), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), regulation of localization (GO:0032879), organic substance metabolic process (GO:0071704), system process (GO:0003008), catabolic process (GO:0009056), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), detection of stimulus (GO:0051606), cell communication (GO:0007154), primary metabolic process (GO:0044238), positive regulation of cellular process (GO:0048522), detection of external stimulus (GO:0009581), cellular component morphogenesis (GO:0032989), positive regulation of cell death (GO:0010942), negative regulation of cellular component organization (GO:0051129), positive regulation of intracellular transport (GO:0032388), cell development (GO:0048468), cell differentiation (GO:0030154), system development (GO:0048731), animal organ development (GO:0048513), response to growth factor (GO:0070848), regulation of signal transduction (GO:0009966), cellular response to endogenous stimulus (GO:0071495), regulation of macromolecule metabolic process (GO:0060255), detection of abiotic stimulus (GO:0009582), regulation of synapse structure or activity (GO:0050803), circulatory system process (GO:0003013), lymphocyte activation (GO:0046649), phosphorus metabolic process (GO:0006793), regulation of catabolic process (GO:0009894), cell morphogenesis (GO:0000902), leukocyte proliferation (GO:0070661), negative regulation of macromolecule metabolic process (GO:0010605), forebrain development (GO:0030900), regulation of anatomical structure morphogenesis (GO:0022603), regulation of nitrogen compound metabolic process (GO:0051171), cell surface receptor signaling pathway (GO:0007166), cellular component organization (GO:0016043), regulation of cellular component organization (GO:0051128), organic substance catabolic process (GO:1901575), cell migration (GO:0016477), positive regulation of nitrogen compound metabolic process (GO:0051173), positive regulation of signal transduction (GO:0009967), negative regulation of nitrogen compound metabolic process (GO:0051172), positive regulation of protein localization (GO:1903829), regulation of transport (GO:0051049), organonitrogen compound metabolic process (GO:1901564), axon ensheathment (GO:0008366), intracellular signal transduction (GO:0035556), positive regulation of macromolecule metabolic process (GO:0010604), regulation of cellular localization (GO:0060341), protein metabolic process (GO:0019538), regulation of transmembrane transport (GO:0034762), response to oxygen-containing compound (GO:1901700), positive regulation of cellular component organization (GO:0051130), macromolecule metabolic process (GO:0043170), detection of stimulus involved in sensory perception (GO:0050906), response to organic substance (GO:0010033), regulation of cell death (GO:0010941), response to nitrogen compound (GO:1901698), head development (GO:0060322), regulation of cell communication (GO:0010646), positive regulation of cellular metabolic process (GO:0031325), dendrite development (GO:0016358), regulation of cellular metabolic process (GO:0031323), negative regulation of catabolic process (GO:0009895), positive regulation of cell communication (GO:0010647), nervous system process (GO:0050877), regulation of trans-synaptic signaling (GO:0099177), regulation of primary metabolic process (GO:0080090), positive regulation of protein transport (GO:0051222), response to mechanical stimulus (GO:0009612), response to peptide (GO:1901652), response to alcohol (GO:0097305), cell projection organization (GO:0030030), regulation of synapse organization (GO:0050807), regulation of protein metabolic process (GO:0051246), positive regulation of establishment of protein localization (GO:1904951), cell part morphogenesis (GO:0032990), regulation of establishment of protein localization (GO:0070201), protein catabolic process (GO:0030163), detection of mechanical stimulus (GO:0050982), regulation of gene expression (GO:0010468), neuron development (GO:0048666), detection of mechanical stimulus involved in sensory perception (GO:0050974), brain development (GO:0007420), macromolecule catabolic process (GO:0009057), macromolecule modification (GO:0043412), regulation of protein transport (GO:0051223), cell morphogenesis involved in differentiation (GO:0000904), nervous system development (GO:0007399), neuron migration (GO:0001764), detection of stimulus involved in sensory perception of pain (GO:0062149), heart process (GO:0003015), central nervous system development (GO:0007417), positive regulation of intracellular signal transduction (GO:1902533), dendrite morphogenesis (GO:0048813), positive regulation of protein localization to nucleus (GO:1900182), cell projection morphogenesis (GO:0048858), negative regulation of gene expression (GO:0010629), regulation of intracellular transport (GO:0032386), positive regulation of neuron death (GO:1901216), response to platelet-derived growth factor (GO:0036119), response to transforming growth factor beta (GO:0071559), regulation of cell morphogenesis (GO:0022604), negative regulation of protein catabolic process (GO:0042177), lymphocyte proliferation (GO:0046651), positive regulation of intracellular protein transport (GO:0090316), organonitrogen compound catabolic process (GO:1901565), positive regulation of phosphorus metabolic process (GO:0010562), regulation of cell projection organization (GO:0031344), regulation of protein catabolic process (GO:0042176), myelination (GO:0042552), regulation of monoatomic ion transmembrane transport (GO:0034765), negative regulation of protein metabolic process (GO:0051248), modulation of chemical synaptic transmission (GO:0050804), regulation of neuron death (GO:1901214), phosphate-containing compound metabolic process (GO:0006796), regulation of protein localization (GO:0032880), mononuclear cell proliferation (GO:0032943), positive regulation of protein localization to membrane (GO:1905477), sensory perception (GO:0007600), protein modification process (GO:0036211), neurogenesis (GO:0022008), response to organonitrogen compound (GO:0010243), positive regulation of cell projection organization (GO:0031346), I-kappaB kinase/NF-kappaB signaling (GO:0007249), positive regulation of protein metabolic process (GO:0051247), T cell activation (GO:0042110), negative regulation of cell projection organization (GO:0031345), regulation of monoatomic ion transport (GO:0043269), neuron differentiation (GO:0030182), cellular response to growth factor stimulus (GO:0071363), regulation of phosphorus metabolic process (GO:0051174), regulation of intracellular signal transduction (GO:1902531), cellular response to platelet-derived growth factor stimulus (GO:0036120), regulation of protein localization to membrane (GO:1905475), response to ethanol (GO:0045471), negative regulation of protein modification process (GO:0031400), positive regulation of phosphate metabolic process (GO:0045937), plasma membrane bounded cell projection morphogenesis (GO:0120039), regulation of metal ion transport (GO:0010959), peptidyl-amino acid modification (GO:0018193), phosphorylation (GO:0016310), T cell proliferation (GO:0042098), positive regulation of protein targeting to membrane (GO:0090314), generation of neurons (GO:0048699), regulation of monoatomic cation transmembrane transport (GO:1904062), regulation of protein localization to nucleus (GO:1900180), positive regulation of protein modification process (GO:0031401), regulation of cell shape (GO:0008360), cell morphogenesis involved in neuron differentiation (GO:0048667), cellular response to transforming growth factor beta stimulus (GO:0071560), regulation of postsynapse organization (GO:0099175), regulation of plasma membrane bounded cell projection organization (GO:0120035), regulation of protein modification process (GO:0031399), positive regulation of neuron projection development (GO:0010976), protein phosphorylation (GO:0006468), protein modification by small protein conjugation or removal (GO:0070647), regulation of intracellular protein transport (GO:0033157), plasma membrane bounded cell projection organization (GO:0120036), regulation of phosphate metabolic process (GO:0019220), detection of mechanical stimulus involved in sensory perception of pain (GO:0050966), response to amyloid-beta (GO:1904645), regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122), neuron projection development (GO:0031175), sensory perception of pain (GO:0019233), positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123), sensory perception of mechanical stimulus (GO:0050954), regulation of protein phosphorylation (GO:0001932), neuron projection morphogenesis (GO:0048812), regulation of dendritic spine maintenance (GO:1902950), regulation of calcium ion transport (GO:0051924), positive regulation of phosphorylation (GO:0042327), positive regulation of protein phosphorylation (GO:0001934), protein modification by small protein conjugation (GO:0032446), regulation of neuron projection development (GO:0010975), peptidyl-tyrosine modification (GO:0018212), regulation of protein targeting (GO:1903533), regulation of phosphorylation (GO:0042325), peptidyl-tyrosine phosphorylation (GO:0018108), regulation of protein modification by small protein conjugation or removal (GO:1903320), negative regulation of protein modification by small protein conjugation or removal (GO:1903321), regulation of protein targeting to membrane (GO:0090313), regulation of calcium ion transmembrane transport (GO:1903169), protein autophosphorylation (GO:0046777), regulation of tyrosine phosphorylation of STAT protein (GO:0042509), regulation of peptidyl-tyrosine phosphorylation (GO:0050730), negative regulation of protein ubiquitination (GO:0031397), positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731), regulation of protein ubiquitination (GO:0031396), protein ubiquitination (GO:0016567), positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)

Cellular Component: cellular_component (GO:0005575), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), cell projection (GO:0042995), membrane (GO:0016020), cell body (GO:0044297), cytosol (GO:0005829), cell periphery (GO:0071944), cell junction (GO:0030054), postsynapse (GO:0098794), somatodendritic compartment (GO:0036477), cytoplasm (GO:0005737), endomembrane system (GO:0012505), supramolecular complex (GO:0099080), plasma membrane bounded cell projection (GO:0120025), cytoplasmic vesicle (GO:0031410), intracellular organelle (GO:0043229), endosome (GO:0005768), synapse (GO:0045202), non-membrane-bounded organelle (GO:0043228), supramolecular polymer (GO:0099081), membrane microdomain (GO:0098857), dendritic tree (GO:0097447), membrane-bounded organelle (GO:0043227), plasma membrane (GO:0005886), postsynaptic specialization (GO:0099572), membrane raft (GO:0045121), Schaffer collateral - CA1 synapse (GO:0098685), intracellular membrane-bounded organelle (GO:0043231), intracellular non-membrane-bounded organelle (GO:0043232), postsynaptic density (GO:0014069), dendrite (GO:0030425), neuron projection (GO:0043005), glial cell projection (GO:0097386), neuron to neuron synapse (GO:0098984), supramolecular fiber (GO:0099512), vesicle (GO:0031982), polymeric cytoskeletal fiber (GO:0099513), asymmetric synapse (GO:0032279), intracellular vesicle (GO:0097708), cytoskeleton (GO:0005856), actin cytoskeleton (GO:0015629), actin filament (GO:0005884)

Generated by BioReason

Deep Research Bioreason Rl

(Fyn-deep-research-bioreason-rl.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:30 AM

Organism: Mus musculus

Sequence:

MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Thinking Trace

Functional Summary

UniProt Summary

Probable receptor tyrosine kinase.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 68-195
SH3 domain (IPR001452, domain) — residues 82-143
Fyn/Yrk, SH3 domain (IPR035750, domain) — residues 85-140
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 88-531
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-291
Fyn/Yrk, SH2 domain (IPR047924, domain) — residues 145-245
SH2 domain (IPR000980, domain) — residues 147-246
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Protein kinase domain (IPR000719, domain) — residues 271-524
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 271-518
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 271-520
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 277-299
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 386-398

GO Terms

Generated by BioReason

Bioreason Rl Review

(Fyn-bioreason-rl-review.md)

BioReason-Pro RL Review: Fyn (mouse)

Source: Fyn-deep-research-bioreason-rl.md

Correctness: 5/5
Completeness: 3/5

Functional Summary Review

The BioReason functional summary is accurate but generic:

A cytoplasmic, non-receptor tyrosine kinase that uses SH3- and SH2-mediated docking to assemble on membrane-proximal signaling complexes and phosphorylate tyrosine residues via a conserved catalytic core. By coupling high-affinity substrate targeting with ATP-fueled catalysis, it propagates intracellular signaling pathways that regulate adhesion, cytoskeletal remodeling, and survival decisions in mouse cells.

This correctly identifies the SH3-SH2-kinase domain architecture, the non-receptor tyrosine kinase identity (GO:0004713), and the cytoplasmic localization. The mention of adhesion and cytoskeletal remodeling is appropriate for a Src-family kinase.

However, the summary is essentially a generic description that would apply to any Src-family kinase (Src, Fyn, Yes, Lck, Lyn, etc.) without distinguishing Fyn-specific biology. Fyn has well-characterized specific roles in: (1) T-cell receptor signaling (the Fyn-T isoform), (2) myelination and oligodendrocyte development, (3) tau phosphorylation and Alzheimer's disease pathogenesis, (4) NMDA receptor regulation at synapses, and (5) lipid raft-associated signaling. None of these are mentioned. The curated review lists GO:0048156 (tau protein binding) and GO:0043014 (alpha-tubulin binding) as specific MF annotations.

The functional summary also omits the N-terminal myristoylation/palmitoylation that targets Fyn to membrane rafts, which is a distinctive feature compared to Src.

Comparison with interpro2go:

The curated review has one GO_REF:0000002 annotation: GO:0005524 (ATP binding). BioReason's summary describes ATP-dependent catalysis consistent with this but provides no additional interpro2go-level insight. The summary largely mirrors what interpro2go would predict from the SH3-SH2-kinase architecture (protein tyrosine kinase activity, ATP binding, intracellular signal transduction) without adding Fyn-specific biology. This is a case where BioReason is essentially recapitulating domain-based predictions dressed up in narrative form.

Notes on thinking trace

The trace correctly identifies the Fyn/Yrk-specific SH3 and SH2 domain annotations (IPR035750, IPR047924) but does not leverage this family-level specificity in the functional summary. The mechanistic model of SH3/SH2-guided docking followed by kinase catalysis is standard textbook Src-family kinase biology.

📄 View Raw YAML

id: P39688
gene_symbol: Fyn
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Fyn'
alternative_products:
- name: 1 (B)
  id: P39688-1
- name: 2 (T)
  id: P39688-2
  sequence_note: VSP_024111, VSP_024112
existing_annotations:
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030154
    label: cell differentiation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007169
    label: cell surface receptor protein tyrosine kinase signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043204
    label: perikaryon
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10077576
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12372285
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15102471
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16316995
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16847311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25417160
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27474268
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7730365
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8631859
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9535845
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9890970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000304
    label: response to singlet oxygen
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001664
    label: G protein-coupled receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003015
    label: heart process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005768
    label: endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007216
    label: G protein-coupled glutamate receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0009410
    label: response to xenobiotic stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010730
    label: negative regulation of hydrogen peroxide biosynthetic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030101
    label: natural killer cell activation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031802
    label: type 5 metabotropic glutamate receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042608
    label: T cell receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042609
    label: CD4 receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042610
    label: CD8 receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043524
    label: negative regulation of neuron apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043548
    label: phosphatidylinositol 3-kinase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051428
    label: peptide hormone receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070851
    label: growth factor receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071363
    label: cellular response to growth factor stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071375
    label: cellular response to peptide hormone stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097038
    label: perinuclear endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097718
    label: disordered domain specific binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0099092
    label: postsynaptic density, intracellular component
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902176
    label: negative regulation of oxidative stress-induced intrinsic apoptotic signaling
      pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905232
    label: cellular response to L-glutamate
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905430
    label: cellular response to glycine
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001240
    label: negative regulation of extrinsic apoptotic signaling pathway in absence
      of ligand
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003015
    label: heart process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005768
    label: endosome
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007216
    label: G protein-coupled glutamate receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030101
    label: natural killer cell activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070851
    label: growth factor receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097718
    label: disordered domain specific binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046777
    label: protein autophosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000304
    label: response to singlet oxygen
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010730
    label: negative regulation of hydrogen peroxide biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031802
    label: type 5 metabotropic glutamate receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042608
    label: T cell receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042609
    label: CD4 receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042610
    label: CD8 receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043524
    label: negative regulation of neuron apoptotic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043548
    label: phosphatidylinositol 3-kinase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051428
    label: peptide hormone receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097038
    label: perinuclear endoplasmic reticulum
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0099092
    label: postsynaptic density, intracellular component
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902176
    label: negative regulation of oxidative stress-induced intrinsic apoptotic signaling
      pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905232
    label: cellular response to L-glutamate
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905430
    label: cellular response to glycine
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001240
    label: negative regulation of extrinsic apoptotic signaling pathway in absence
      of ligand
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9507006
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IMP
  original_reference_id: PMID:27525436
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900449
    label: regulation of glutamate receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:16709819
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928613
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-983702
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420398
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016525
    label: negative regulation of angiogenesis
  evidence_type: IMP
  original_reference_id: PMID:10613822
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12526739
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0038026
    label: reelin-mediated signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:12526739
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IMP
  original_reference_id: PMID:1361685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IDA
  original_reference_id: PMID:1361685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098685
    label: Schaffer collateral - CA1 synapse
  evidence_type: IMP
  original_reference_id: PMID:1361685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098685
    label: Schaffer collateral - CA1 synapse
  evidence_type: IDA
  original_reference_id: PMID:1361685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010467
    label: gene expression
  evidence_type: IGI
  original_reference_id: PMID:31461442
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:23169819
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090314
    label: positive regulation of protein targeting to membrane
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902951
    label: negative regulation of dendritic spine maintenance
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904645
    label: response to amyloid-beta
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905664
    label: regulation of calcium ion import across plasma membrane
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:10557075
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:28598420
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:28598420
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043014
    label: alpha-tubulin binding
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048156
    label: tau protein binding
  evidence_type: IPI
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12681493
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:12681493
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:26901312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26901312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22685302
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003015
    label: heart process
  evidence_type: IGI
  original_reference_id: PMID:27525436
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044297
    label: cell body
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097386
    label: glial cell projection
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-1433273
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-2395436
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928613
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928635
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9605258
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680646
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680706
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682158
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682572
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763892
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763903
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9764150
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9817994
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9818009
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-983702
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420388
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420398
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-421136
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-421138
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9032771
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20655099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IMP
  original_reference_id: PMID:20655099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IMP
  original_reference_id: PMID:20655099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8551236
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:24627473
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031397
    label: negative regulation of protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:24627473
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071560
    label: cellular response to transforming growth factor beta stimulus
  evidence_type: IGI
  original_reference_id: PMID:21829547
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005768
    label: endosome
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005884
    label: actin filament
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036120
    label: cellular response to platelet-derived growth factor stimulus
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071944
    label: cell periphery
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IGI
  original_reference_id: PMID:23169819
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001664
    label: G protein-coupled receptor binding
  evidence_type: IPI
  original_reference_id: PMID:23169819
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900182
    label: positive regulation of protein localization to nucleus
  evidence_type: IMP
  original_reference_id: PMID:20142099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11711534
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10872802
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:20142099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900182
    label: positive regulation of protein localization to nucleus
  evidence_type: IDA
  original_reference_id: PMID:20142099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042531
    label: positive regulation of tyrosine phosphorylation of STAT protein
  evidence_type: IMP
  original_reference_id: PMID:23438599
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9185665
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010976
    label: positive regulation of neuron projection development
  evidence_type: IGI
  original_reference_id: PMID:18354028
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8196616
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9655502
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048813
    label: dendrite morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:12372285
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:17923684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17923684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:17923684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:17923684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9177270
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008360
    label: regulation of cell shape
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:10872802
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8196616
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: IPI
  original_reference_id: PMID:12538589
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:20978343
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:16841086
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042177
    label: negative regulation of protein catabolic process
  evidence_type: IMP
  original_reference_id: PMID:16841086
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420382
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420394
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420386
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7799925
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:9381182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045471
    label: response to ethanol
  evidence_type: IGI
  original_reference_id: PMID:9381182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046777
    label: protein autophosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050798
    label: activated T cell proliferation
  evidence_type: IMP
  original_reference_id: PMID:1516132
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:16190898
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:9892651
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050966
    label: detection of mechanical stimulus involved in sensory perception of pain
  evidence_type: IMP
  original_reference_id: PMID:16190898
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:10872802
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10713104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001764
    label: neuron migration
  evidence_type: IMP
  original_reference_id: PMID:15073522
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030900
    label: forebrain development
  evidence_type: IMP
  original_reference_id: PMID:15073522
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001764
    label: neuron migration
  evidence_type: IGI
  original_reference_id: PMID:16162939
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030900
    label: forebrain development
  evidence_type: IGI
  original_reference_id: PMID:16162939
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8196616
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0015631
    label: tubulin binding
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042552
    label: myelination
  evidence_type: TAS
  original_reference_id: PMID:11826099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-rat orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-human orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10077576
  title: 'Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1
    is a Src substrate during mitosis.'
  findings: []
- id: PMID:10557075
  title: wt p53 dependent expression of a membrane-associated isoform of adenylate
    kinase.
  findings: []
- id: PMID:10613822
  title: Signals leading to apoptosis-dependent inhibition of neovascularization by
    thrombospondin-1.
  findings: []
- id: PMID:10713104
  title: HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation
    of erythroid cells.
  findings: []
- id: PMID:10872802
  title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor
    proteins.
  findings: []
- id: PMID:11711534
  title: '''Srcasm: a novel Src activating and signaling molecule.'
  findings: []
- id: PMID:11826099
  title: Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase
    with the cytoskeletal protein tau.
  findings: []
- id: PMID:12372285
  title: Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation
    of dendrite orientation in cerebral cortex.
  findings: []
- id: PMID:12526739
  title: Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.
  findings: []
- id: PMID:12538589
  title: Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation.
    SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates
    its response to hypotonic stress.
  findings: []
- id: PMID:12681493
  title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex
    in mast cells.
  findings: []
- id: PMID:1361685
  title: Impaired long-term potentiation, spatial learning, and hippocampal development
    in fyn mutant mice.
  findings: []
- id: PMID:15073522
  title: Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.
  findings: []
- id: PMID:15102471
  title: Bioinformatics and cellular signaling.
  findings: []
- id: PMID:1516132
  title: Defective T cell receptor signaling in mice lacking the thymic isoform of
    p59fyn.
  findings: []
- id: PMID:16162939
  title: Absence of Fyn and Src causes a reeler-like phenotype.
  findings: []
- id: PMID:16190898
  title: Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472
    is essential for maintenance of neuropathic pain.
  findings: []
- id: PMID:16316995
  title: IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of
    sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
  findings: []
- id: PMID:16709819
  title: Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
  findings: []
- id: PMID:16841086
  title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase
    enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell
    survival.
  findings: []
- id: PMID:16847311
  title: 'Association between SAP and FynT: Inducible SH3 domain-mediated interaction
    controlled by engagement of the SLAM receptor.'
  findings: []
- id: PMID:17623777
  title: The membrane targeting and spatial activation of Src, Yes and Fyn is influenced
    by palmitoylation and distinct RhoB/RhoD endosome requirements.
  findings: []
- id: PMID:17923684
  title: Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
  findings: []
- id: PMID:18354028
  title: Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires
    Fyn kinase and contributes to postnatal CNS development in vivo.
  findings: []
- id: PMID:20142099
  title: Fyn-dependent regulation of energy expenditure and body weight is mediated
    by tyrosine phosphorylation of LKB1.
  findings: []
- id: PMID:20655099
  title: Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease
    mouse models.
  findings: []
- id: PMID:20978343
  title: CD36 participates in a signaling pathway that regulates ROS formation in
    murine VSMCs.
  findings: []
- id: PMID:21829547
  title: Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3
    activation and PAI-1 expression.
  findings: []
- id: PMID:22685302
  title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C
    (UNC5C) in netrin-1-mediated growth cone collapse.
  findings: []
- id: PMID:22820466
  title: Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates
    Fyn to impair neurons.
  findings: []
- id: PMID:23169819
  title: GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
  findings: []
- id: PMID:23438599
  title: Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.
  findings: []
- id: PMID:24627473
  title: Phosphorylation of the antiviral protein interferon-inducible transmembrane
    protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination.
  findings: []
- id: PMID:25417160
  title: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition
    and metastasis.
  findings: []
- id: PMID:26901312
  title: A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine
    Fyn Binding Protein.
  findings: []
- id: PMID:27474268
  title: Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells
    identifies CD5 as a key regulator of TCR-induced ubiquitylation.
  findings: []
- id: PMID:27525436
  title: Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.
  findings: []
- id: PMID:28598420
  title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol
    1,4,5-trisphosphate receptors.
  findings: []
- id: PMID:31461442
  title: A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial
    cells and endothelial cells.
  findings: []
- id: PMID:7730365
  title: Sequence requirements for binding of Src family tyrosine kinases to activated
    growth factor receptors.
  findings: []
- id: PMID:7799925
  title: Association of p62, a multifunctional SH2- and SH3-domain-binding protein,
    with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.
  findings: []
- id: PMID:8175795
  title: CD45 regulation of tyrosine phosphorylation and enzyme activity of src family
    kinases.
  findings: []
- id: PMID:8196616
  title: 'Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs:
    defining the nature of a signalling motif.'
  findings: []
- id: PMID:8551236
  title: Association of tyrosine protein kinase Zap-70 with the protooncogene product
    p120c-cbl in T lymphocytes.
  findings: []
- id: PMID:8631859
  title: The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex
    during insulin stimulation.
  findings: []
- id: PMID:9177270
  title: 'Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional
    and physical association with src-kinases.'
  findings: []
- id: PMID:9185665
  title: Molecular cloning of Fyn-associated molecules in the mouse central nervous
    system.
  findings: []
- id: PMID:9381182
  title: 'Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor
    function.'
  findings: []
- id: PMID:9507006
  title: Identification of sirm, a novel insulin-regulated SH3 binding protein that
    associates with Grb-2 and FYN.
  findings: []
- id: PMID:9535845
  title: Physical and functional interactions between receptor-like protein-tyrosine
    phosphatase alpha and p59fyn.
  findings: []
- id: PMID:9655502
  title: Diversity revealed by a novel family of cadherins expressed in neurons at
    a synaptic complex.
  findings: []
- id: PMID:9890970
  title: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding
    site for phosphatidylinositol 3-kinase.
  findings: []
- id: PMID:9892651
  title: PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate
    receptor subunit NR2A.
  findings: []
- id: Reactome:R-MMU-1433273
  title: Interaction of Src kinases with c-Kit
  findings: []
- id: Reactome:R-MMU-2395436
  title: Phosphorylation of DAP12
  findings: []
- id: Reactome:R-MMU-3928613
  title: Fyn phosphorylates Nmdar2b
  findings: []
- id: Reactome:R-MMU-3928635
  title: Ephb2 bind Nmdar
  findings: []
- id: Reactome:R-MMU-420382
  title: Phosphorylation of FAK by Src kinases
  findings: []
- id: Reactome:R-MMU-420394
  title: Recruitment of FAK to NCAM1:Fyn in lipid rafts
  findings: []
- id: Reactome:R-MMU-9032771
  title: Dock3 binds Fyn associated with Ntrk2
  findings: []
- id: Reactome:R-MMU-9605258
  title: Active Flt3 binds Fyn
  findings: []
- id: Reactome:R-MMU-9680646
  title: Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11
    (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2)  bind
    p-8Y-Csf1r and are activated
  findings: []
- id: Reactome:R-MMU-9680706
  title: Csf1r trans-autophosphorylates on multiple tyrosine residues
  findings: []
- id: Reactome:R-MMU-9682158
  title: Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate
    and 1,2-diacylglycerol
  findings: []
- id: Reactome:R-MMU-9682182
  title: Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
  findings: []
- id: Reactome:R-MMU-9682572
  title: Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
  findings: []
- id: Reactome:R-MMU-9763891
  title: Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl
  findings: []
- id: Reactome:R-MMU-9763892
  title: p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
  findings: []
- id: Reactome:R-MMU-9763903
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9764150
  title: Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r
    dimer:SFK and Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9817994
  title: Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
  findings: []
- id: Reactome:R-MMU-9818009
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1
  findings: []
- id: Reactome:R-MMU-983702
  title: Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
  findings: []
- id: Reactome:R-NUL-420386
  title: Fyn binds NCAM1
  findings: []
- id: Reactome:R-NUL-420388
  title: Dephosphorylation of NCAM1 bound pFyn
  findings: []
- id: Reactome:R-NUL-420398
  title: Autophosphorylation of NCAM1 bound Fyn
  findings: []
- id: Reactome:R-NUL-421136
  title: Recruitment and activation of Cdk5
  findings: []
- id: Reactome:R-NUL-421138
  title: Activation of Fyn
  findings: []

Fyn

Gene Description

Existing Annotations Review

References

📚 Additional Documentation

Deep Research Bioreason

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Deep Research Bioreason Rl

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Bioreason Rl Review

BioReason-Pro RL Review: Fyn (mouse)

Functional Summary Review

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