Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005886 plasma membrane	IBA GO_REF:0000033	ACCEPT	Summary: plasma membrane is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005102 signaling receptor binding	IBA GO_REF:0000033	MARK AS OVER ANNOTATED	Summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030154 cell differentiation	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: cell differentiation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Fyn participates in cell surface receptor protein tyrosine kinase signaling pathways, but this is one of several receptor/signaling contexts for the Src-family kinase rather than the sole core role. Reason: Supported secondary or context-specific role. GO:0007169 is more specific than intracellular signal transduction and should not be replaced by its broader parent. Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IBA GO_REF:0000033	ACCEPT	Summary: non-membrane spanning protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050852 T cell receptor signaling pathway	IBA GO_REF:0000033	ACCEPT	Summary: T cell receptor signaling pathway is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004672 protein kinase activity	IEA GO_REF:0000120	MODIFY	Summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity for this gene. Reason: Use a more specific GO term supported by the gene product role Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: non-membrane spanning protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005524 ATP binding	IEA GO_REF:0000002	ACCEPT	Summary: ATP binding is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005634 nucleus	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: nucleus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005737 cytoplasm	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: cytoplasm is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005886 plasma membrane	IEA GO_REF:0000120	ACCEPT	Summary: plasma membrane is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043204 perikaryon	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: perikaryon is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:10077576 Characterization of Sam68-like mammalian proteins SLM-1 and ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is invol...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:15102471 Bioinformatics and cellular signaling.	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:16316995 IgE-dependent activation of sphingosine kinases 1 and 2 and ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:16847311 Association between SAP and FynT: Inducible SH3 domain-media...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:25417160 A noncanonical Frizzled2 pathway regulates epithelial-mesenc...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:27474268 Co-recruitment analysis of the CBL and CBLB signalosomes in ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:7730365 Sequence requirements for binding of Src family tyrosine kin...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:8631859 The Fyn tyrosine kinase binds Irs-1 and forms a distinct sig...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:9535845 Physical and functional interactions between receptor-like p...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:9890970 Fyn associates with Cbl and phosphorylates tyrosine 731 in C...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0000304 response to singlet oxygen	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to singlet oxygen is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0001664 G protein-coupled receptor binding	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: G protein-coupled receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0003015 heart process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: heart process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005102 signaling receptor binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005739 mitochondrion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mitochondrion is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005768 endosome	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: endosome is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	IEA GO_REF:0000107	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0007216 G protein-coupled glutamate receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: G protein-coupled glutamate receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0009410 response to xenobiotic stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to xenobiotic stimulus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of hydrogen peroxide biosynthetic process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0014069 postsynaptic density	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0016004 phospholipase activator activity	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phospholipase activator activity is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0019899 enzyme binding	IEA GO_REF:0000120	MARK AS OVER ANNOTATED	Summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030101 natural killer cell activation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: natural killer cell activation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030425 dendrite	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: dendrite is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0031802 type 5 metabotropic glutamate receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: type 5 metabotropic glutamate receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0035556 intracellular signal transduction	IEA GO_REF:0000120	ACCEPT	Summary: intracellular signal transduction is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042220 response to cocaine	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: response to cocaine is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042608 T cell receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: T cell receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042609 CD4 receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: CD4 receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042610 CD8 receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: CD8 receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042802 identical protein binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: identical protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043274 phospholipase binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phospholipase binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043524 negative regulation of neuron apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of neuron apoptotic process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043548 phosphatidylinositol 3-kinase binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0044877 protein-containing complex binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: protein-containing complex binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0045121 membrane raft	IEA GO_REF:0000107	ACCEPT	Summary: membrane raft is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0046875 ephrin receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: ephrin receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0048471 perinuclear region of cytoplasm	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: perinuclear region of cytoplasm is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050852 T cell receptor signaling pathway	IEA GO_REF:0000107	ACCEPT	Summary: T cell receptor signaling pathway is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050860 negative regulation of T cell receptor signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of T cell receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050868 negative regulation of T cell activation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of T cell activation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0051428 peptide hormone receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: peptide hormone receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0070301 cellular response to hydrogen peroxide	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to hydrogen peroxide is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0070851 growth factor receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: growth factor receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0071363 cellular response to growth factor stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to growth factor stimulus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0071375 cellular response to peptide hormone stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to peptide hormone stimulus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097038 perinuclear endoplasmic reticulum	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: perinuclear endoplasmic reticulum is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097110 scaffold protein binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: scaffold protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097718 disordered domain specific binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: disordered domain specific binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0098978 glutamatergic synapse	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: glutamatergic synapse is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0099092 postsynaptic density, intracellular component	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: postsynaptic density, intracellular component is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1904646 cellular response to amyloid-beta	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to amyloid-beta is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1905232 cellular response to L-glutamate	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to L-glutamate is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1905430 cellular response to glycine	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to glycine is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0003015 heart process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: heart process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: non-membrane spanning protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005768 endosome	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: endosome is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	ISO GO_REF:0000119	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005886 plasma membrane	ISO GO_REF:0000119	ACCEPT	Summary: plasma membrane is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0007216 G protein-coupled glutamate receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: G protein-coupled glutamate receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0016004 phospholipase activator activity	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phospholipase activator activity is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0019899 enzyme binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030101 natural killer cell activation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: natural killer cell activation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030425 dendrite	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: dendrite is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0035556 intracellular signal transduction	ISO GO_REF:0000119	ACCEPT	Summary: intracellular signal transduction is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042802 identical protein binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: identical protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043274 phospholipase binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: phospholipase binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0045121 membrane raft	ISO GO_REF:0000119	ACCEPT	Summary: membrane raft is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0046875 ephrin receptor binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ephrin receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050852 T cell receptor signaling pathway	ISO GO_REF:0000119	ACCEPT	Summary: T cell receptor signaling pathway is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050860 negative regulation of T cell receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of T cell receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050868 negative regulation of T cell activation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: negative regulation of T cell activation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0070851 growth factor receptor binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: growth factor receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097110 scaffold protein binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: scaffold protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097718 disordered domain specific binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: disordered domain specific binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1904646 cellular response to amyloid-beta	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cellular response to amyloid-beta is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0046777 protein autophosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: protein autophosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0000304 response to singlet oxygen	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: response to singlet oxygen is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004672 protein kinase activity	ISO GO_REF:0000096	MODIFY	Summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity for this gene. Reason: Use a more specific GO term supported by the gene product role Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000096	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005102 signaling receptor binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005634 nucleus	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: nucleus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005739 mitochondrion	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mitochondrion is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of hydrogen peroxide biosynthetic process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0014069 postsynaptic density	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0019899 enzyme binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030425 dendrite	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: dendrite is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0031802 type 5 metabotropic glutamate receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: type 5 metabotropic glutamate receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0035556 intracellular signal transduction	ISO GO_REF:0000096	ACCEPT	Summary: intracellular signal transduction is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042608 T cell receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: T cell receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042609 CD4 receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: CD4 receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042610 CD8 receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: CD8 receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043524 negative regulation of neuron apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of neuron apoptotic process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043548 phosphatidylinositol 3-kinase binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0044877 protein-containing complex binding	ISO GO_REF:0000096	MARK AS OVER ANNOTATED	Summary: protein-containing complex binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0048471 perinuclear region of cytoplasm	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: perinuclear region of cytoplasm is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0051428 peptide hormone receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: peptide hormone receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0070301 cellular response to hydrogen peroxide	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to hydrogen peroxide is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097038 perinuclear endoplasmic reticulum	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: perinuclear endoplasmic reticulum is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0098978 glutamatergic synapse	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: glutamatergic synapse is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0099092 postsynaptic density, intracellular component	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: postsynaptic density, intracellular component is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1905232 cellular response to L-glutamate	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to L-glutamate is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1905430 cellular response to glycine	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: cellular response to glycine is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:9507006 Identification of sirm, a novel insulin-regulated SH3 bindin...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISS GO_REF:0000024	ACCEPT	Summary: non-membrane spanning protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050860 negative regulation of T cell receptor signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: negative regulation of T cell receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050868 negative regulation of T cell activation	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: negative regulation of T cell activation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0035556 intracellular signal transduction	IMP PMID:27525436 Tyrosine kinase FYN negatively regulates NOX4 in cardiac rem...	ACCEPT	Summary: intracellular signal transduction is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0035556 intracellular signal transduction	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	ACCEPT	Summary: intracellular signal transduction is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1900449 regulation of glutamate receptor signaling pathway	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	KEEP AS NON CORE	Summary: regulation of glutamate receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	EXP PMID:16709819 Regulation of Ly49D/DAP12 signal transduction by Src-family ...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-3928613	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9763891	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-983702	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-NUL-420398	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0016525 negative regulation of angiogenesis	IMP PMID:10613822 Signals leading to apoptosis-dependent inhibition of neovasc...	KEEP AS NON CORE	Summary: negative regulation of angiogenesis is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:12526739 Fyn tyrosine kinase is a critical regulator of disabled-1 du...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0038026 reelin-mediated signaling pathway	IDA PMID:12526739 Fyn tyrosine kinase is a critical regulator of disabled-1 du...	ACCEPT	Summary: reelin-mediated signaling pathway is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050804 modulation of chemical synaptic transmission	IMP PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	KEEP AS NON CORE	Summary: modulation of chemical synaptic transmission is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050804 modulation of chemical synaptic transmission	IDA PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	KEEP AS NON CORE	Summary: modulation of chemical synaptic transmission is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0098685 Schaffer collateral - CA1 synapse	IMP PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	KEEP AS NON CORE	Summary: Schaffer collateral - CA1 synapse is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0098685 Schaffer collateral - CA1 synapse	IDA PMID:1361685 Impaired long-term potentiation, spatial learning, and hippo...	KEEP AS NON CORE	Summary: Schaffer collateral - CA1 synapse is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0010467 gene expression	IGI PMID:31461442 A bigenic mouse model of FSGS reveals perturbed pathways in ...	KEEP AS NON CORE	Summary: gene expression is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0090314 positive regulation of protein targeting to membrane	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	KEEP AS NON CORE	Summary: positive regulation of protein targeting to membrane is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1902951 negative regulation of dendritic spine maintenance	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	KEEP AS NON CORE	Summary: negative regulation of dendritic spine maintenance is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1904645 response to amyloid-beta	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	KEEP AS NON CORE	Summary: response to amyloid-beta is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1905664 regulation of calcium ion import across plasma membrane	IGI PMID:22820466 Alzheimer amyloid-β oligomer bound to postsynaptic prion pro...	KEEP AS NON CORE	Summary: regulation of calcium ion import across plasma membrane is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005886 plasma membrane	IDA PMID:10557075 wt p53 dependent expression of a membrane-associated isoform...	REMOVE	Summary: This PMID does not provide direct evidence for Fyn plasma membrane localization; it localizes AK1beta rather than establishing the annotated location for Fyn. Reason: Cited evidence does not support this gene-product annotation
GO:0004713 protein tyrosine kinase activity	IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:28598420 Tespa1 regulates T cell receptor-induced calcium signals by ...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0043014 alpha-tubulin binding	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: alpha-tubulin binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0048156 tau protein binding	IPI PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: tau protein binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:12681493 Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 ...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:12681493 Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 ...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:26901312 A Central Nervous System-Dependent Intron-Embedded Gene Enco...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:26901312 A Central Nervous System-Dependent Intron-Embedded Gene Enco...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:22685302 Down syndrome cell adhesion molecule (DSCAM) associates with...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0003015 heart process	IGI PMID:27525436 Tyrosine kinase FYN negatively regulates NOX4 in cardiac rem...	KEEP AS NON CORE	Summary: heart process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0044297 cell body	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: cell body is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0045121 membrane raft	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	ACCEPT	Summary: membrane raft is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0097386 glial cell projection	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: glial cell projection is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-1433273	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-2395436	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-3928613	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-3928635	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9605258	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9680646	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9680706	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9682158	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9682182	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9682572	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9763891	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9763892	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9763903	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9764150	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9817994	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-9818009	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-983702	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-NUL-420388	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-NUL-420398	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-NUL-421136	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-NUL-421138	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005886 plasma membrane	TAS Reactome:R-MMU-9032771	ACCEPT	Summary: plasma membrane is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0014069 postsynaptic density	IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	KEEP AS NON CORE	Summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030425 dendrite	IMP PMID:20655099 Dendritic function of tau mediates amyloid-beta toxicity in ...	KEEP AS NON CORE	Summary: dendrite is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:8551236 Association of tyrosine protein kinase Zap-70 with the proto...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:24627473 Phosphorylation of the antiviral protein interferon-inducibl...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0031397 negative regulation of protein ubiquitination	IDA PMID:24627473 Phosphorylation of the antiviral protein interferon-inducibl...	KEEP AS NON CORE	Summary: negative regulation of protein ubiquitination is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0071560 cellular response to transforming growth factor beta stimulus	IGI PMID:21829547 Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-...	KEEP AS NON CORE	Summary: cellular response to transforming growth factor beta stimulus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005768 endosome	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	KEEP AS NON CORE	Summary: endosome is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005884 actin filament	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	KEEP AS NON CORE	Summary: actin filament is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0036120 cellular response to platelet-derived growth factor stimulus	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	KEEP AS NON CORE	Summary: cellular response to platelet-derived growth factor stimulus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0071944 cell periphery	IDA PMID:17623777 The membrane targeting and spatial activation of Src, Yes an...	KEEP AS NON CORE	Summary: cell periphery is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IGI PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0001664 G protein-coupled receptor binding	IPI PMID:23169819 GPRC5B activates obesity-associated inflammatory signaling i...	KEEP AS NON CORE	Summary: G protein-coupled receptor binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1900182 positive regulation of protein localization to nucleus	IMP PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	KEEP AS NON CORE	Summary: positive regulation of protein localization to nucleus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:11711534 'Srcasm: a novel Src activating and signaling molecule.	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:1900182 positive regulation of protein localization to nucleus	IDA PMID:20142099 Fyn-dependent regulation of energy expenditure and body weig...	KEEP AS NON CORE	Summary: positive regulation of protein localization to nucleus is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein	IMP PMID:23438599 Fyn regulates adipogenesis by promoting PIKE-A/STAT5a intera...	KEEP AS NON CORE	Summary: positive regulation of tyrosine phosphorylation of STAT protein is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:9185665 Molecular cloning of Fyn-associated molecules in the mouse c...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0010976 positive regulation of neuron projection development	IGI PMID:18354028 Voltage-gated Na+ channel beta1 subunit-mediated neurite out...	KEEP AS NON CORE	Summary: positive regulation of neuron projection development is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:9655502 Diversity revealed by a novel family of cadherins expressed ...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0048813 dendrite morphogenesis	IMP PMID:12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is invol...	KEEP AS NON CORE	Summary: dendrite morphogenesis is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IMP PMID:17923684 Neph1 cooperates with nephrin to transduce a signal that ind...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0007166 cell surface receptor signaling pathway	IDA PMID:9177270 Mouse CD24 as a signaling molecule for integrin-mediated cel...	KEEP AS NON CORE	Summary: cell surface receptor signaling pathway is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0008360 regulation of cell shape	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: regulation of cell shape is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	REMOVE	Summary: This PMID reports APS phosphorylation after cytokine or BCR stimulation but does not identify Fyn as the kinase responsible for that phosphorylation. Reason: Cited evidence does not support this gene-product annotation
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0044325 transmembrane transporter binding	IPI PMID:12538589 Regulation of a transient receptor potential (TRP) channel b...	KEEP AS NON CORE	Summary: transmembrane transporter binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0010629 negative regulation of gene expression	IMP PMID:20978343 CD36 participates in a signaling pathway that regulates ROS ...	KEEP AS NON CORE	Summary: negative regulation of gene expression is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:16841086 Src-family tyrosine kinase fyn phosphorylates phosphatidylin...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042177 negative regulation of protein catabolic process	IMP PMID:16841086 Src-family tyrosine kinase fyn phosphorylates phosphatidylin...	KEEP AS NON CORE	Summary: negative regulation of protein catabolic process is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-420382	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-MMU-420394	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005829 cytosol	TAS Reactome:R-NUL-420386	ACCEPT	Summary: cytosol is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0005515 protein binding	IPI PMID:7799925 Association of p62, a multifunctional SH2- and SH3-domain-bi...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IMP PMID:9381182 Fyn-kinase as a determinant of ethanol sensitivity: relation...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0045471 response to ethanol	IGI PMID:9381182 Fyn-kinase as a determinant of ethanol sensitivity: relation...	KEEP AS NON CORE	Summary: response to ethanol is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	ACCEPT	Summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0046777 protein autophosphorylation	IDA PMID:8175795 CD45 regulation of tyrosine phosphorylation and enzyme activ...	ACCEPT	Summary: protein autophosphorylation is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050798 activated T cell proliferation	IMP PMID:1516132 Defective T cell receptor signaling in mice lacking the thym...	KEEP AS NON CORE	Summary: activated T cell proliferation is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0006468 protein phosphorylation	IMP PMID:16190898 Fyn kinase-mediated phosphorylation of NMDA receptor NR2B su...	MODIFY	Summary: The annotation captures a real aspect of Fyn biology, but protein phosphorylation is less precise than GO:0018108 peptidyl-tyrosine phosphorylation for this gene. Reason: Use a more specific GO term supported by the gene product role Proposed replacements: peptidyl-tyrosine phosphorylation Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0006468 protein phosphorylation	IMP PMID:9892651 PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the...	MODIFY	Summary: The annotation captures a real aspect of Fyn biology, but protein phosphorylation is less precise than GO:0018108 peptidyl-tyrosine phosphorylation for this gene. Reason: Use a more specific GO term supported by the gene product role Proposed replacements: peptidyl-tyrosine phosphorylation Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain	IMP PMID:16190898 Fyn kinase-mediated phosphorylation of NMDA receptor NR2B su...	KEEP AS NON CORE	Summary: detection of mechanical stimulus involved in sensory perception of pain is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	REMOVE	Summary: This PMID does not directly assay or establish Fyn protein tyrosine kinase activity; it reports APS phosphorylation without identifying Fyn as the responsible kinase. Reason: Cited evidence does not support this gene-product annotation
GO:0005515 protein binding	IPI PMID:10713104 HS1 interacts with Lyn and is critical for erythropoietin-in...	MARK AS OVER ANNOTATED	Summary: protein binding is too generic or indirect for Fyn; the evidence supports a more specific signaling, catalytic, adaptor, or localization role. Reason: Overly broad or uninformative relative to the supported core function Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0001764 neuron migration	IMP PMID:15073522 Defective neocortical development in Fyn-tyrosine-kinase-def...	KEEP AS NON CORE	Summary: neuron migration is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030900 forebrain development	IMP PMID:15073522 Defective neocortical development in Fyn-tyrosine-kinase-def...	KEEP AS NON CORE	Summary: forebrain development is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0001764 neuron migration	IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype.	KEEP AS NON CORE	Summary: neuron migration is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0030900 forebrain development	IGI PMID:16162939 Absence of Fyn and Src causes a reeler-like phenotype.	KEEP AS NON CORE	Summary: forebrain development is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004713 protein tyrosine kinase activity	IDA PMID:8196616 Interactions of p59fyn and ZAP-70 with T-cell receptor activ...	ACCEPT	Summary: protein tyrosine kinase activity is directly supported as part of the core molecular function, direct pathway role, or primary localization of Fyn. Reason: Directly supported core function, process, or location Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0004672 protein kinase activity	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	MODIFY	Summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity for this gene. Reason: Use a more specific GO term supported by the gene product role Proposed replacements: non-membrane spanning protein tyrosine kinase activity Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0015631 tubulin binding	IDA PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: tubulin binding is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.
GO:0042552 myelination	TAS PMID:11826099 Process outgrowth of oligodendrocytes is promoted by interac...	KEEP AS NON CORE	Summary: myelination is biologically plausible for Fyn but represents a context-specific pathway, localization, interaction, phenotype, or downstream response rather than the primary core function. Reason: Supported secondary or context-specific role Supporting Evidence: UniProt:P39688 FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. file:mouse/Fyn/Fyn-deep-research-falcon.md Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.

Core Functions

Fyn phosphorylates tyrosine residues on signaling proteins as a Src-family kinase recruited to membrane-proximal and cytosolic signaling complexes.

Molecular Function:

non-membrane spanning protein tyrosine kinase activity

Directly Involved In:

peptidyl-tyrosine phosphorylation intracellular signal transduction

Cellular Locations:

cytosol plasma membrane membrane raft

Supporting Evidence:

UniProt:P39688
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts.
file:mouse/Fyn/Fyn-deep-research-falcon.md
Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.

Isoform- and cell-context-specific Fyn signaling contributes directly to T-cell receptor and neuronal reelin/synaptic pathways.

Molecular Function:

protein tyrosine kinase activity

Directly Involved In:

T cell receptor signaling pathway reelin-mediated signaling pathway

Cellular Locations:

cytosol plasma membrane

Supporting Evidence:

UniProt:P39688
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts.
file:mouse/Fyn/Fyn-deep-research-falcon.md
Falcon deep research report reviewed for GO term specificity, core-function context, and evidence synthesis.

References

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000096

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000119

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10077576

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.

PMID:10557075

wt p53 dependent expression of a membrane-associated isoform of adenylate kinase.

PMID:10613822

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

PMID:10713104

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.

PMID:10872802

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.

PMID:11711534

'Srcasm: a novel Src activating and signaling molecule.

PMID:11826099

Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.

PMID:12372285

Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.

PMID:12526739

Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.

PMID:12538589

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.

PMID:12681493

Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells.

PMID:1361685

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

PMID:15073522

Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.

PMID:15102471

Bioinformatics and cellular signaling.

PMID:1516132

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.

PMID:16162939

Absence of Fyn and Src causes a reeler-like phenotype.

PMID:16190898

Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.

PMID:16316995

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.

PMID:16709819

Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.

PMID:16841086

Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.

PMID:16847311

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.

PMID:17623777

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

PMID:17923684

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.

PMID:18354028

Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.

PMID:20142099

Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.

PMID:20655099

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

PMID:20978343

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.

PMID:21829547

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

PMID:22685302

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PMID:22820466

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

PMID:23169819

GPRC5B activates obesity-associated inflammatory signaling in adipocytes.

PMID:23438599

Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

PMID:24627473

Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination.

PMID:25417160

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

PMID:26901312

A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine Fyn Binding Protein.

PMID:27474268

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.

PMID:27525436

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.

PMID:28598420

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.

PMID:31461442

A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells.

PMID:7730365

Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors.

PMID:7799925

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.

PMID:8175795

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

PMID:8196616

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.

PMID:8551236

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

PMID:8631859

The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.

PMID:9177270

Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases.

PMID:9185665

Molecular cloning of Fyn-associated molecules in the mouse central nervous system.

PMID:9381182

Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.

PMID:9507006

Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.

PMID:9535845

Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.

PMID:9655502

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PMID:9890970

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.

PMID:9892651

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

Reactome:R-MMU-1433273

Interaction of Src kinases with c-Kit

Reactome:R-MMU-2395436

Phosphorylation of DAP12

Reactome:R-MMU-3928613

Fyn phosphorylates Nmdar2b

Reactome:R-MMU-3928635

Ephb2 bind Nmdar

Reactome:R-MMU-420382

Phosphorylation of FAK by Src kinases

Reactome:R-MMU-420394

Recruitment of FAK to NCAM1:Fyn in lipid rafts

Reactome:R-MMU-9032771

Dock3 binds Fyn associated with Ntrk2

Reactome:R-MMU-9605258

Active Flt3 binds Fyn

Reactome:R-MMU-9680646

Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated

Reactome:R-MMU-9680706

Csf1r trans-autophosphorylates on multiple tyrosine residues

Reactome:R-MMU-9682158

Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Reactome:R-MMU-9682182

Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Reactome:R-MMU-9682572

Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Reactome:R-MMU-9763891

Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl

Reactome:R-MMU-9763892

p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12

Reactome:R-MMU-9763903

Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Reactome:R-MMU-9764150

Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1

Reactome:R-MMU-9817994

Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

Reactome:R-MMU-9818009

Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1

Reactome:R-MMU-983702

Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)

Reactome:R-NUL-420386

Fyn binds NCAM1

Reactome:R-NUL-420388

Dephosphorylation of NCAM1 bound pFyn

Reactome:R-NUL-420398

Autophosphorylation of NCAM1 bound Fyn

Reactome:R-NUL-421136

Recruitment and activation of Cdk5

Reactome:R-NUL-421138

Activation of Fyn

UniProt:P39688

UniProt record for Fyn (P39688)

file:mouse/Fyn/Fyn-deep-research-bioreason.md

Deep research report on Fyn (bioreason)

file:mouse/Fyn/Fyn-deep-research-bioreason-rl.md

Deep research report on Fyn (bioreason-rl)

file:mouse/Fyn/Fyn-deep-research-falcon.md

Deep research report on Fyn (falcon)

📚 Additional Documentation

Deep Research Bioreason

(Fyn-deep-research-bioreason.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:30 AM

Organism: Mus musculus

Sequence:

MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Thinking Trace

I begin by dissecting the InterPro architecture and its order along the polypeptide. The N-terminal third contains IPR036028 (SH3-like domain superfamily, residues 68–195) with a discrete IPR001452 SH3 domain (residues 82–143) refined by the lineage-specific IPR035750 Fyn/Yrk SH3 domain (residues 85–140). Immediately downstream sits the SH2 module ensemble: IPR036860 SH2 domain superfamily (residues 140–291), IPR047924 Fyn/Yrk SH2 domain (residues 145–245), and the canonical IPR000980 SH2 domain (residues 147–246). The C-terminal half transitions into the catalytic core: IPR011009 protein kinase-like domain superfamily (residues 258–528) and the folded bilobal kinase engine defined by IPR000719 protein kinase domain (residues 271–524), IPR001245 serine-threonine/tyrosine-protein kinase catalytic domain (residues 271–518), and IPR020635 tyrosine-protein kinase catalytic domain (residues 271–520). Within this engine, IPR017441 marks the ATP-binding site (residues 277–299), and IPR008266 annotates the tyrosine-kinase active site (residues 386–398). The overall architecture is capped by IPR050198 non-receptor tyrosine kinases involved in cell signaling (family, residues 88–531), which ties the SH3–SH2–kinase triad into a signaling-competent enzyme typical of Src-family kinases.

This ordered SH3–SH2–kinase arrangement dictates molecular function. The SH3 domain binds proline-rich motifs, positioning substrates or adaptors. The SH2 domain binds phosphotyrosine motifs, docking the enzyme onto activated receptors and scaffolds. The C-terminal kinase domain—equipped with a defined ATP-binding pocket and a tyrosine-kinase catalytic loop—causes phosphorylation of tyrosine residues. Therefore, the molecular function necessarily includes protein tyrosine kinase activity and ATP binding, and is reinforced by multivalent protein binding mediated by SH3 and SH2. The combination of IPR000719/IPR001245/IPR020635 together with the ATP-binding and catalytic motifs compels a precise enzymatic identity: a non-receptor tyrosine kinase that transfers the γ-phosphate of ATP to tyrosyl residues.

From this chemistry, the biological process follows. Tyrosine phosphorylation is a central switch in signal transduction cascades. The presence of the SH3–SH2 targeting modules upstream of a robust catalytic core positions the enzyme as a driver of intracellular signal transduction. Such kinases regulate adhesion, cytoskeletal remodeling, and survival pathways; thus they operate broadly within signal transduction and intracellular signal transduction, coordinating downstream effectors once tyrosine residues are primed by SH2-mediated docking.

Cellular location is inferred from both the soluble modular architecture and the typical membrane-proximal role of Src-family kinases. The absence of transmembrane segments and the soluble nature of SH3/SH2/kinase modules support a cytoplasmic enzyme that samples membrane-associated complexes via transient interactions. This aligns with a cytoplasmic residency, where membrane-proximal scaffolds and receptors are surveyed.

Mechanistically, the SH3 and SH2 domains assemble a targeting hub that recruits proline-rich adaptors and phosphotyrosine-bearing complexes. This targeting funnels substrates into the catalytic cleft, where ATP binding (residues 277–299) primes the active site to phosphorylate tyrosine residues via the conserved catalytic loop (residues 386–398). I hypothesize that this kinase transiently associates with membrane-proximal scaffolds and receptors—such as focal adhesion and immune-receptor assemblies—where SH2/SH3-guided docking concentrates it on activated signaling platforms. Likely partners include proline-rich adaptors and phosphotyrosine-rich scaffolds that nucleate pathways controlling adhesion and cytoskeletal dynamics. Together, the SH3–SH2–kinase architecture explains how this cytoplasmic enzyme executes tyrosine phosphorylation to propagate intracellular signaling.

Functional Summary

A cytoplasmic, non-receptor tyrosine kinase that uses SH3- and SH2-mediated docking to assemble on membrane-proximal signaling complexes and phosphorylate tyrosine residues via a conserved catalytic core. By coupling high-affinity substrate targeting with ATP-fueled catalysis, it propagates intracellular signaling pathways that regulate adhesion, cytoskeletal remodeling, and survival decisions in mouse cells.

UniProt Summary

Probable receptor tyrosine kinase.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 68-195
SH3 domain (IPR001452, domain) — residues 82-143
Fyn/Yrk, SH3 domain (IPR035750, domain) — residues 85-140
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 88-531
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-291
Fyn/Yrk, SH2 domain (IPR047924, domain) — residues 145-245
SH2 domain (IPR000980, domain) — residues 147-246
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Protein kinase domain (IPR000719, domain) — residues 271-524
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 271-518
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 271-520
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 277-299
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 386-398

GO Terms

Molecular Function: molecular_function (GO:0003674), binding (GO:0005488), catalytic activity (GO:0003824), transferase activity (GO:0016740), catalytic activity, acting on a protein (GO:0140096), protein binding (GO:0005515), signaling receptor binding (GO:0005102), transferase activity, transferring phosphorus-containing groups (GO:0016772), protein kinase activity (GO:0004672), transmembrane transporter binding (GO:0044325), cytoskeletal protein binding (GO:0008092), kinase activity (GO:0016301), phosphotransferase activity, alcohol group as acceptor (GO:0016773), protein tyrosine kinase activity (GO:0004713), G protein-coupled receptor binding (GO:0001664), tau protein binding (GO:0048156), tubulin binding (GO:0015631), alpha-tubulin binding (GO:0043014)

Biological Process: biological_process (GO:0008150), positive regulation of biological process (GO:0048518), regulation of biological process (GO:0050789), signaling (GO:0023052), multicellular organismal process (GO:0032501), biological regulation (GO:0065007), response to stimulus (GO:0050896), developmental process (GO:0032502), cellular process (GO:0009987), metabolic process (GO:0008152), immune system process (GO:0002376), negative regulation of biological process (GO:0048519), response to external stimulus (GO:0009605), anatomical structure development (GO:0048856), anatomical structure morphogenesis (GO:0009653), cell motility (GO:0048870), response to chemical (GO:0042221), leukocyte activation (GO:0045321), cell population proliferation (GO:0008283), nitrogen compound metabolic process (GO:0006807), cellular component organization or biogenesis (GO:0071840), ensheathment of neurons (GO:0007272), positive regulation of transport (GO:0051050), negative regulation of metabolic process (GO:0009892), regulation of developmental process (GO:0050793), regulation of biological quality (GO:0065008), response to endogenous stimulus (GO:0009719), regulation of cellular process (GO:0050794), regulation of response to stimulus (GO:0048583), cellular response to stimulus (GO:0051716), regulation of signaling (GO:0023051), negative regulation of cellular process (GO:0048523), signal transduction (GO:0007165), cellular developmental process (GO:0048869), response to abiotic stimulus (GO:0009628), positive regulation of signaling (GO:0023056), cell activation (GO:0001775), multicellular organism development (GO:0007275), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), regulation of localization (GO:0032879), organic substance metabolic process (GO:0071704), system process (GO:0003008), catabolic process (GO:0009056), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), detection of stimulus (GO:0051606), cell communication (GO:0007154), primary metabolic process (GO:0044238), positive regulation of cellular process (GO:0048522), detection of external stimulus (GO:0009581), cellular component morphogenesis (GO:0032989), positive regulation of cell death (GO:0010942), negative regulation of cellular component organization (GO:0051129), positive regulation of intracellular transport (GO:0032388), cell development (GO:0048468), cell differentiation (GO:0030154), system development (GO:0048731), animal organ development (GO:0048513), response to growth factor (GO:0070848), regulation of signal transduction (GO:0009966), cellular response to endogenous stimulus (GO:0071495), regulation of macromolecule metabolic process (GO:0060255), detection of abiotic stimulus (GO:0009582), regulation of synapse structure or activity (GO:0050803), circulatory system process (GO:0003013), lymphocyte activation (GO:0046649), phosphorus metabolic process (GO:0006793), regulation of catabolic process (GO:0009894), cell morphogenesis (GO:0000902), leukocyte proliferation (GO:0070661), negative regulation of macromolecule metabolic process (GO:0010605), forebrain development (GO:0030900), regulation of anatomical structure morphogenesis (GO:0022603), regulation of nitrogen compound metabolic process (GO:0051171), cell surface receptor signaling pathway (GO:0007166), cellular component organization (GO:0016043), regulation of cellular component organization (GO:0051128), organic substance catabolic process (GO:1901575), cell migration (GO:0016477), positive regulation of nitrogen compound metabolic process (GO:0051173), positive regulation of signal transduction (GO:0009967), negative regulation of nitrogen compound metabolic process (GO:0051172), positive regulation of protein localization (GO:1903829), regulation of transport (GO:0051049), organonitrogen compound metabolic process (GO:1901564), axon ensheathment (GO:0008366), intracellular signal transduction (GO:0035556), positive regulation of macromolecule metabolic process (GO:0010604), regulation of cellular localization (GO:0060341), protein metabolic process (GO:0019538), regulation of transmembrane transport (GO:0034762), response to oxygen-containing compound (GO:1901700), positive regulation of cellular component organization (GO:0051130), macromolecule metabolic process (GO:0043170), detection of stimulus involved in sensory perception (GO:0050906), response to organic substance (GO:0010033), regulation of cell death (GO:0010941), response to nitrogen compound (GO:1901698), head development (GO:0060322), regulation of cell communication (GO:0010646), positive regulation of cellular metabolic process (GO:0031325), dendrite development (GO:0016358), regulation of cellular metabolic process (GO:0031323), negative regulation of catabolic process (GO:0009895), positive regulation of cell communication (GO:0010647), nervous system process (GO:0050877), regulation of trans-synaptic signaling (GO:0099177), regulation of primary metabolic process (GO:0080090), positive regulation of protein transport (GO:0051222), response to mechanical stimulus (GO:0009612), response to peptide (GO:1901652), response to alcohol (GO:0097305), cell projection organization (GO:0030030), regulation of synapse organization (GO:0050807), regulation of protein metabolic process (GO:0051246), positive regulation of establishment of protein localization (GO:1904951), cell part morphogenesis (GO:0032990), regulation of establishment of protein localization (GO:0070201), protein catabolic process (GO:0030163), detection of mechanical stimulus (GO:0050982), regulation of gene expression (GO:0010468), neuron development (GO:0048666), detection of mechanical stimulus involved in sensory perception (GO:0050974), brain development (GO:0007420), macromolecule catabolic process (GO:0009057), macromolecule modification (GO:0043412), regulation of protein transport (GO:0051223), cell morphogenesis involved in differentiation (GO:0000904), nervous system development (GO:0007399), neuron migration (GO:0001764), detection of stimulus involved in sensory perception of pain (GO:0062149), heart process (GO:0003015), central nervous system development (GO:0007417), positive regulation of intracellular signal transduction (GO:1902533), dendrite morphogenesis (GO:0048813), positive regulation of protein localization to nucleus (GO:1900182), cell projection morphogenesis (GO:0048858), negative regulation of gene expression (GO:0010629), regulation of intracellular transport (GO:0032386), positive regulation of neuron death (GO:1901216), response to platelet-derived growth factor (GO:0036119), response to transforming growth factor beta (GO:0071559), regulation of cell morphogenesis (GO:0022604), negative regulation of protein catabolic process (GO:0042177), lymphocyte proliferation (GO:0046651), positive regulation of intracellular protein transport (GO:0090316), organonitrogen compound catabolic process (GO:1901565), positive regulation of phosphorus metabolic process (GO:0010562), regulation of cell projection organization (GO:0031344), regulation of protein catabolic process (GO:0042176), myelination (GO:0042552), regulation of monoatomic ion transmembrane transport (GO:0034765), negative regulation of protein metabolic process (GO:0051248), modulation of chemical synaptic transmission (GO:0050804), regulation of neuron death (GO:1901214), phosphate-containing compound metabolic process (GO:0006796), regulation of protein localization (GO:0032880), mononuclear cell proliferation (GO:0032943), positive regulation of protein localization to membrane (GO:1905477), sensory perception (GO:0007600), protein modification process (GO:0036211), neurogenesis (GO:0022008), response to organonitrogen compound (GO:0010243), positive regulation of cell projection organization (GO:0031346), I-kappaB kinase/NF-kappaB signaling (GO:0007249), positive regulation of protein metabolic process (GO:0051247), T cell activation (GO:0042110), negative regulation of cell projection organization (GO:0031345), regulation of monoatomic ion transport (GO:0043269), neuron differentiation (GO:0030182), cellular response to growth factor stimulus (GO:0071363), regulation of phosphorus metabolic process (GO:0051174), regulation of intracellular signal transduction (GO:1902531), cellular response to platelet-derived growth factor stimulus (GO:0036120), regulation of protein localization to membrane (GO:1905475), response to ethanol (GO:0045471), negative regulation of protein modification process (GO:0031400), positive regulation of phosphate metabolic process (GO:0045937), plasma membrane bounded cell projection morphogenesis (GO:0120039), regulation of metal ion transport (GO:0010959), peptidyl-amino acid modification (GO:0018193), phosphorylation (GO:0016310), T cell proliferation (GO:0042098), positive regulation of protein targeting to membrane (GO:0090314), generation of neurons (GO:0048699), regulation of monoatomic cation transmembrane transport (GO:1904062), regulation of protein localization to nucleus (GO:1900180), positive regulation of protein modification process (GO:0031401), regulation of cell shape (GO:0008360), cell morphogenesis involved in neuron differentiation (GO:0048667), cellular response to transforming growth factor beta stimulus (GO:0071560), regulation of postsynapse organization (GO:0099175), regulation of plasma membrane bounded cell projection organization (GO:0120035), regulation of protein modification process (GO:0031399), positive regulation of neuron projection development (GO:0010976), protein phosphorylation (GO:0006468), protein modification by small protein conjugation or removal (GO:0070647), regulation of intracellular protein transport (GO:0033157), plasma membrane bounded cell projection organization (GO:0120036), regulation of phosphate metabolic process (GO:0019220), detection of mechanical stimulus involved in sensory perception of pain (GO:0050966), response to amyloid-beta (GO:1904645), regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122), neuron projection development (GO:0031175), sensory perception of pain (GO:0019233), positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123), sensory perception of mechanical stimulus (GO:0050954), regulation of protein phosphorylation (GO:0001932), neuron projection morphogenesis (GO:0048812), regulation of dendritic spine maintenance (GO:1902950), regulation of calcium ion transport (GO:0051924), positive regulation of phosphorylation (GO:0042327), positive regulation of protein phosphorylation (GO:0001934), protein modification by small protein conjugation (GO:0032446), regulation of neuron projection development (GO:0010975), peptidyl-tyrosine modification (GO:0018212), regulation of protein targeting (GO:1903533), regulation of phosphorylation (GO:0042325), peptidyl-tyrosine phosphorylation (GO:0018108), regulation of protein modification by small protein conjugation or removal (GO:1903320), negative regulation of protein modification by small protein conjugation or removal (GO:1903321), regulation of protein targeting to membrane (GO:0090313), regulation of calcium ion transmembrane transport (GO:1903169), protein autophosphorylation (GO:0046777), regulation of tyrosine phosphorylation of STAT protein (GO:0042509), regulation of peptidyl-tyrosine phosphorylation (GO:0050730), negative regulation of protein ubiquitination (GO:0031397), positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731), regulation of protein ubiquitination (GO:0031396), protein ubiquitination (GO:0016567), positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)

Cellular Component: cellular_component (GO:0005575), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), cell projection (GO:0042995), membrane (GO:0016020), cell body (GO:0044297), cytosol (GO:0005829), cell periphery (GO:0071944), cell junction (GO:0030054), postsynapse (GO:0098794), somatodendritic compartment (GO:0036477), cytoplasm (GO:0005737), endomembrane system (GO:0012505), supramolecular complex (GO:0099080), plasma membrane bounded cell projection (GO:0120025), cytoplasmic vesicle (GO:0031410), intracellular organelle (GO:0043229), endosome (GO:0005768), synapse (GO:0045202), non-membrane-bounded organelle (GO:0043228), supramolecular polymer (GO:0099081), membrane microdomain (GO:0098857), dendritic tree (GO:0097447), membrane-bounded organelle (GO:0043227), plasma membrane (GO:0005886), postsynaptic specialization (GO:0099572), membrane raft (GO:0045121), Schaffer collateral - CA1 synapse (GO:0098685), intracellular membrane-bounded organelle (GO:0043231), intracellular non-membrane-bounded organelle (GO:0043232), postsynaptic density (GO:0014069), dendrite (GO:0030425), neuron projection (GO:0043005), glial cell projection (GO:0097386), neuron to neuron synapse (GO:0098984), supramolecular fiber (GO:0099512), vesicle (GO:0031982), polymeric cytoskeletal fiber (GO:0099513), asymmetric synapse (GO:0032279), intracellular vesicle (GO:0097708), cytoskeleton (GO:0005856), actin cytoskeleton (GO:0015629), actin filament (GO:0005884)

Generated by BioReason

Deep Research Bioreason Rl

(Fyn-deep-research-bioreason-rl.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:30 AM

Organism: Mus musculus

Sequence:

MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Thinking Trace

Functional Summary

UniProt Summary

Probable receptor tyrosine kinase.

InterPro Domains

SH3-like domain superfamily (IPR036028, homologous_superfamily) — residues 68-195
SH3 domain (IPR001452, domain) — residues 82-143
Fyn/Yrk, SH3 domain (IPR035750, domain) — residues 85-140
Non-receptor tyrosine kinases involved in cell signaling (IPR050198, family) — residues 88-531
SH2 domain superfamily (IPR036860, homologous_superfamily) — residues 140-291
Fyn/Yrk, SH2 domain (IPR047924, domain) — residues 145-245
SH2 domain (IPR000980, domain) — residues 147-246
Protein kinase-like domain superfamily (IPR011009, homologous_superfamily) — residues 258-528
Protein kinase domain (IPR000719, domain) — residues 271-524
Serine-threonine/tyrosine-protein kinase, catalytic domain (IPR001245, domain) — residues 271-518
Tyrosine-protein kinase, catalytic domain (IPR020635, domain) — residues 271-520
Protein kinase, ATP binding site (IPR017441, binding_site) — residues 277-299
Tyrosine-protein kinase, active site (IPR008266, active_site) — residues 386-398

GO Terms

Generated by BioReason

Deep Research Falcon

(Fyn-deep-research-falcon.md)

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organism: mouse
gene_id: Fyn
gene_symbol: Fyn
uniprot_accession: P39688
protein_description: 'RecName: Full=Tyrosine-protein kinase Fyn; EC=2.7.10.2 {ECO:0000269|PubMed:12526739,
ECO:0000269|PubMed:12681493}; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=p59-Fyn;'
gene_info: Name=Fyn;
organism_full: Mus musculus (Mouse).
protein_family: Belongs to the protein kinase superfamily. Tyr protein
protein_domains: Fyn/Yrk_SH2. (IPR047924); Fyn/Yrk_SH3. (IPR035750); Kinase-like_dom_sf.
(IPR011009); Non-receptor_tyrosine_kinases. (IPR050198); Prot_kinase_dom. (IPR000719)
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citation_count: 41

Question

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.

Target Gene/Protein Identity (from UniProt):

UniProt Accession: P39688
Protein Description: RecName: Full=Tyrosine-protein kinase Fyn; EC=2.7.10.2 {ECO:0000269|PubMed:12526739, ECO:0000269|PubMed:12681493}; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=p59-Fyn;
Gene Information: Name=Fyn;
Organism (full): Mus musculus (Mouse).
Protein Family: Belongs to the protein kinase superfamily. Tyr protein
Key Domains: Fyn/Yrk_SH2. (IPR047924); Fyn/Yrk_SH3. (IPR035750); Kinase-like_dom_sf. (IPR011009); Non-receptor_tyrosine_kinases. (IPR050198); Prot_kinase_dom. (IPR000719)

MANDATORY VERIFICATION STEPS:

Check if the gene symbol "Fyn" matches the protein description above
Verify the organism is correct: Mus musculus (Mouse).
Check if protein family/domains align with what you find in literature
If you find literature for a DIFFERENT gene with the same or similar symbol, STOP

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE. Instead:
- State clearly: "The gene symbol 'Fyn' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information

Research Target:

Please provide a comprehensive research report on the gene Fyn (gene ID: Fyn, UniProt: P39688) in mouse.

The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.

We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.

We are interested in where in or outside the cell the gene product carries out its function.

We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.

Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.

Output

Question: You are an expert researcher providing comprehensive, well-cited information.

Provide detailed information focusing on:
1. Key concepts and definitions with current understanding
2. Recent developments and latest research (prioritize 2023-2024 sources)
3. Current applications and real-world implementations
4. Expert opinions and analysis from authoritative sources
5. Relevant statistics and data from recent studies

Format as a comprehensive research report with proper citations. Include URLs and publication dates where available.
Always prioritize recent, authoritative sources and provide specific citations for all major claims.

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.

Target Gene/Protein Identity (from UniProt):

UniProt Accession: P39688
Protein Description: RecName: Full=Tyrosine-protein kinase Fyn; EC=2.7.10.2 {ECO:0000269|PubMed:12526739, ECO:0000269|PubMed:12681493}; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=p59-Fyn;
Gene Information: Name=Fyn;
Organism (full): Mus musculus (Mouse).
Protein Family: Belongs to the protein kinase superfamily. Tyr protein
Key Domains: Fyn/Yrk_SH2. (IPR047924); Fyn/Yrk_SH3. (IPR035750); Kinase-like_dom_sf. (IPR011009); Non-receptor_tyrosine_kinases. (IPR050198); Prot_kinase_dom. (IPR000719)

MANDATORY VERIFICATION STEPS:

Check if the gene symbol "Fyn" matches the protein description above
Verify the organism is correct: Mus musculus (Mouse).
Check if protein family/domains align with what you find in literature
If you find literature for a DIFFERENT gene with the same or similar symbol, STOP

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Please provide a comprehensive research report on the gene Fyn (gene ID: Fyn, UniProt: P39688) in mouse.

The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

We are interested in where in or outside the cell the gene product carries out its function.

We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.

Research report: Functional annotation of mouse Fyn (UniProt P39688, Mus musculus)

0) Identity verification (critical)

The UniProt accession P39688 corresponds to Mus musculus tyrosine-protein kinase Fyn (proto-oncogene c-Fyn; p59-Fyn), a Src-family non-receptor tyrosine kinase with canonical Src-family SH domains and a protein-tyrosine kinase catalytic domain, consistent with the target description provided. (zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 1-2, peng2023fynemergingbiological pages 1-3)

1) Key concepts, definitions, and current understanding

1.1 What Fyn is (core definition)

Fyn is a non-receptor protein tyrosine kinase in the Src-family kinases (SFKs). Its primary biochemical function is to phosphorylate tyrosine residues on intracellular protein substrates, acting as a signaling hub in multiple pathways in immune and nervous systems. (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 1-3)

1.2 Domain architecture (how Fyn works as a signaling enzyme)

Recent reviews describing Fyn’s structure outline the canonical SFK layout:
- SH4 N-terminus (membrane attachment / palmitoylation module)
- “Unique” region
- SH3 and SH2 interaction modules (substrate/adaptor docking)
- SH1 catalytic kinase domain (ATP-dependent tyrosine phosphorylation) (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 1-3)

This modular organization explains how Fyn integrates (i) membrane targeting, (ii) regulated activation/inactivation, and (iii) selective docking to signaling complexes.

1.3 Catalytic activity and substrate specificity (what reaction it catalyzes)

Fyn catalyzes transfer of phosphate from ATP to tyrosine residues on protein substrates (protein-tyrosine kinase activity). In recent reviews, Fyn is described as phosphorylating tyrosines on diverse signaling proteins across pathways rather than having a narrow substrate repertoire; reported examples include phosphorylation-dependent regulation of synaptic NMDAR-associated targets and broad signaling substrates in oncogenic contexts (e.g., Cas, LKB1, IP3R1, COX2 in cancer-focused review literature). (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 3-5)

1.4 Regulation by phosphorylation (on/off switching)

Fyn activity is controlled by conserved SFK regulatory tyrosines:
- Tyr420 (activation-loop; phosphorylation promotes the active state)
- Tyr531 (C-terminal inhibitory site; phosphorylation stabilizes an autoinhibited “closed” conformation via intramolecular interaction) (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 3-5)

This SH2-mediated autoinhibition and activation-loop phosphorylation is the central concept underlying pharmacologic SFK inhibition strategies.

1.5 Subcellular localization (where Fyn acts)

Fyn is predominantly localized to the cytoplasmic leaflet of the plasma membrane, driven by N-terminal lipidation:
- Myristoylation and palmitoylation localize Fyn to the inner membrane layer (xu2024fynanimportant pages 1-2)
- Membrane targeting is also discussed via the SH4 region/palmitoylation module and association with membrane microdomains/rafts (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 13-14)

Because many of its substrates are within receptor-proximal complexes, this membrane localization is fundamental to Fyn’s role in immune receptor and synaptic signaling.

2) Functional roles and pathways (mechanistic focus)

2.1 Immune signaling: TCR proximal signaling and downstream fate decisions

Fyn is positioned in proximal T cell receptor (TCR) signaling networks and can function redundantly/overlapping with Lck in early receptor-triggered phosphorylation cascades. Reviews and mechanistic work emphasize TCR-linked Fyn activity in T cell activation programs. (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 1-3)

A major 2024 mechanistic advance is direct linkage of TCR signaling to STAT3 activation:
- TCR stimulation induces STAT3 phosphorylation at Y705 through a Lck/Fyn-dependent axis.
- This TCR→Lck/Fyn→STAT3(Y705) route is mechanistically distinct from cytokine-JAK STAT3 activation (Srci1 blocks TCR-induced STAT3 phosphorylation but not cytokine-JAK–driven phosphorylation). (qin2024tcrsignalinginduces pages 2-4, qin2024tcrsignalinginduces pages 1-2)

This supports a model where Fyn (with Lck) not only initiates proximal receptor phosphorylation but also shapes T helper differentiation by controlling a transcription-factor node (STAT3) critical for TH17 programs.

2.2 Engineered T cells (real-world implementation): CAR-T signaling can be Fyn-driven

A 2023 Cell Reports Medicine study reports that CD28-containing CAR designs can use Fyn to support signaling when Lck is absent, depending on CD28 motifs (notably PYAP). Key findings include:
- CAR engagement increased Fyn activation (pY420) ~2-fold after 30 minutes.
- CRISPR FYN knockout dramatically reduced CAR-driven IL-2 production.
- The work argues CD28-CAR signaling can proceed through Fyn-mediated ITAM phosphorylation, enabling Lck-independent CAR function, with functional benefits such as reduced exhaustion and improved memory/proliferation profiles in vivo in Lck-deficient CAR-T settings. (wu2023cd28cartcellactivation pages 3-5, wu2023cd28cartcellactivation pages 1-3, wu2023cd28cartcellactivation pages 5-9)

These results are a concrete example of “functional annotation” translating into engineering design principles: Fyn is not merely a redundant SFK but can be preferentially exploited for desired signaling phenotypes.

2.3 Neurons/synapses: Fyn in excitatory synaptic signaling

Fyn participates in synaptic transmission and plasticity at excitatory synapses. A key mechanism described in recent review text is:
- PSD95 interaction with the SH2 domain of Fyn facilitates Fyn phosphorylation of tyrosines on NMDAR subunits (including NR2A context), increasing NMDAR activity and supporting NMDAR-dependent synaptic potentiation. (xu2024fynanimportant pages 3-4)

This synaptic role also connects Fyn to excitotoxicity and seizure-related pathology via postsynaptic signaling complexes (see epilepsy section below).

2.4 Microglia/neuroinflammation: Fyn→Stat3/NF-κB inflammatory axis

Recent literature positions Fyn upstream of inflammatory signaling in myeloid-lineage brain cells. In a 2024 Disease Models & Mechanisms study using a constitutively active Fyn (FynY531F) neural activation model:
- Fyn activation increased Stat3-Y705 phosphorylation and induced inflammatory cytokines.
- Stat3 inhibition (S3I-201, 10 µM) rescued dopaminergic neuron loss (cell counts not significantly different from controls; P=0.99) and reduced amoeboid microglia (P=0.0015).
- Fyn/SFK inhibition with saracatinib (10 µM) reduced Stat3-Y705 phosphorylation to control levels.
- NF-κB inhibition (CAPE) also rescued neuron loss; dual inhibition showed Stat3 and NF-κB act synergistically. (siddiqui2024stat3mediatesfyn pages 7-8, siddiqui2024stat3mediatesfyn pages 8-10, siddiqui2024stat3mediatesfyn pages 10-12)

Together, these data provide a mechanistic narrative for Fyn as a driver of neuroinflammatory signaling that can be pharmacologically modulated.

2.5 Oligodendrocytes/myelination: Fyn as a pro-myelinating signaling node

Fyn is repeatedly implicated in oligodendrocyte differentiation and CNS myelination. Recent 2024 reviews summarize:
- Fyn is active during the myelination period and is required for oligodendrocyte morphological differentiation and myelination programs.
- Fyn knockout mice show substantial forebrain myelin loss across ages (reported from ~P14 to 1 year). (xu2024fynanimportant pages 1-2)

Mechanistically, Fyn is described as linking upstream cues (e.g., integrins/TrkB-associated signaling) to cytoskeletal remodeling pathways, including Rho-family GTPases and p190 RhoGAP phosphorylation, supporting process extension and axon contact. (zhou2024theunderlyingmolecular pages 2-3, zhou2024theunderlyingmolecular pages 8-8, zhou2024theunderlyingmolecular pages 7-7)

3) Recent developments (prioritizing 2023–2024)

Key 2023–2024 advances for functional annotation of Fyn include:
1. TCR-driven STAT3 phosphorylation via Lck/Fyn as a determinant of TH17 differentiation and autoimmune disease phenotypes (EAE) (Feb 2024). (qin2024tcrsignalinginduces pages 2-4, qin2024tcrsignalinginduces pages 1-2)
2. Fyn-centered CAR-T signaling for CD28 CAR constructs enabling Lck-independent activation and potentially improved therapeutic performance (Feb 2023). (wu2023cd28cartcellactivation pages 3-5, wu2023cd28cartcellactivation pages 1-3)
3. Fyn→Stat3/NF-κB axis in in vivo neuroinflammation/neurodegeneration models with quantitative pharmacologic rescue (Dec 2024). (siddiqui2024stat3mediatesfyn pages 7-8, siddiqui2024stat3mediatesfyn pages 8-10)
4. Epilepsy-associated Fyn–tau and NMDAR-complex interactions and their modulation by SFK inhibition with quantitative seizure and molecular outcomes (Sep 2024). (putra2024enhancedfyntauand pages 14-15)

4) Current applications and real-world implementations

4.1 Pharmacologic modulation: SFK inhibitors as Fyn-pathway probes and candidates

Because Fyn is an SFK, most pharmacologic tools are SFK inhibitors (not perfectly Fyn-selective). Recent sources highlight:
- Saracatinib (AZD0530) as a commonly used SFK inhibitor with reported ~10 nM IC50 against Fyn in a 2023 review and extensive preclinical use. (peng2023fynemergingbiological pages 8-10)
- PP1 as a selective SFK inhibitor (Src/Lck/Fyn-inhibitory) used in non-neural disease models to suppress fibrotic/inflammatory signaling nodes (TGF-β/Smad3, STAT3, ERK, NF-κB) in hyperuricemic nephropathy. (xiong2024pharmacologicalinhibitionof pages 1-2)
- NXP900 as a newer SFK inhibitor that stabilizes inactive conformations, designed to inhibit both kinase activity and kinase-independent scaffold functions; reported to have ~1,000-fold selectivity over ABL and in phase 1 clinical evaluation. (dash2024thesrcfamily pages 1-2)

4.2 Epilepsy disease modification (preclinical translational example)

A 2024 Brain Communications study reports that saracatinib modulates a Fyn-associated postsynaptic signaling module in chronic epilepsy:
- SAR reduced PSD markers pSFK-Y416 (P=0.021), pTau-AT8 (P=0.035), pNR2B-Y1472 (P=0.043).
- SAR reduced Fyn–tau PLA puncta (P=0.007) and NR2B–PSD95 PLA puncta (P=0.0385).
- SAR reduced convulsive seizures/day during treatment (P=0.0473) and reduced the number of animals with ≥10 seizures/day (SAR 1/10 vs VEH 8/12, P=0.0115). (putra2024enhancedfyntauand pages 14-15)

These results support a mechanistically anchored application: inhibiting SFK/Fyn activity to disrupt a Fyn–tau–NMDAR complex implicated in excitotoxicity and seizure progression.

4.3 Cancer stratification/biomarkers implicating FYN/SFKs

In chemoresistant triple-negative breast cancer, SFK pathway activity (including FYN) is described as upregulated in resistant PDX models and clinically relevant:
- High SFK expression (SRC, FYN and/or YES1) in metastatic lesions associated with shorter disease-free interval (27 vs 105 months). (egeland2024thesrcfamilyserves pages 1-2)

While not mouse-specific, this is a real-world implementation of Fyn/SFK expression as a stratification marker for pathway-targeted therapy.

5) Expert opinions and analysis (from authoritative sources)

Recent reviews converge on a consistent “expert consensus” view:
- Fyn’s biology is best understood as context-dependent signaling hub behavior: its SH2/SH3 docking and membrane targeting drive selective incorporation into receptor-proximal and synaptic complexes, while phosphorylation at conserved regulatory tyrosines toggles activity. (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 1-3)
- In the CNS, reviews emphasize that Fyn can be both physiologic (myelination, synaptic plasticity) and pathologic when aberrantly activated (neuroinflammation, tau/NMDAR-driven excitotoxic modules), motivating continued interest in modulating SFKs with improved selectivity/functional impact. (zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 3-4, putra2024enhancedfyntauand pages 14-15)

6) Data highlights and statistics (recent studies)

Key quantitative results useful for annotation and translational prioritization:
- CD28-CAR-T: ~2-fold increase in Fyn pY420 after CAR engagement (30 min); FYN knockout strongly reduces IL-2 production in CAR-Jurkat cells. (wu2023cd28cartcellactivation pages 3-5)
- Fyn–tau epilepsy module: SAR reduces molecular readouts (pSFK-Y416, pTau-AT8, pNR2B-Y1472) with P-values 0.021–0.043; reduces animals with ≥10 seizures/day from 8/12 to 1/10 (P=0.0115). (putra2024enhancedfyntauand pages 14-15)
- Fyn→Stat3 neuroinflammation: Stat3 inhibition rescues dopaminergic neuron counts to control (P=0.99) and reduces amoeboid microglia (P=0.0015); cytokines il12a and tnfa are suppressed with strong significance in the same study. (siddiqui2024stat3mediatesfyn pages 7-8, siddiqui2024stat3mediatesfyn pages 8-10)
- Gliosis/scarring: In kainate rat epileptogenesis study, saracatinib produced a 42.17% reduction in glial scar size. (rao2023theeffectsof pages 12-14)
- Clinical association (SFK-high TNBC): disease-free interval 27 vs 105 months in fast-progressing vs slower-progressing metastatic cases. (egeland2024thesrcfamilyserves pages 1-2)

7) Visual evidence from a recent primary study

The following retrieved figure panels provide direct visual support for the mechanistic claim that SFK/Fyn inhibition by saracatinib reduces Fyn-associated postsynaptic phosphorylation and Fyn–tau interactions in epilepsy models. (putra2024enhancedfyntauand media 37b3b928, putra2024enhancedfyntauand media b037ed8c)

8) Summary table (evidence map)

Category	Summary
Identity/biochemistry	Mouse Fyn corresponds to UniProt P39688, a Src-family non-receptor protein tyrosine kinase (p59-Fyn; ~537 aa) that catalyzes protein tyrosine phosphorylation on intracellular substrates and signaling adaptors; reviewed functions include T-cell receptor signaling, synaptic signaling, axon guidance, and CNS myelination. Key reported substrates/targets include NR2B/NMDAR-associated complexes, FAK, BCAR1, AMPK, LKB1, IP3R1, and Cas, consistent with broad signaling-node activity rather than narrow sequence-restricted substrate specificity (zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 1-2, peng2023fynemergingbiological pages 1-3, peng2023fynemergingbiological pages 14-14, peng2023fynemergingbiological pages 3-5)
Domains & regulation	Canonical Src-family architecture: SH4 membrane-targeting region, unique region, SH3, SH2, and catalytic SH1/kinase domain. Activation is controlled by phosphorylation of the activation-loop Tyr420 and inhibitory C-terminal Tyr531; Tyr531 phosphorylation promotes the closed/autoinhibited conformation through intramolecular SH2 binding, whereas dephosphorylation opens the kinase for activation. Recent reviews also note brain/immune isoforms including Fyn-B and Fyn-T (zhou2024theunderlyingmolecular pages 2-3, peng2023fynemergingbiological pages 1-3, peng2023fynemergingbiological pages 3-5)
Localization	Predominantly associated with the cytoplasmic leaflet of the plasma membrane through N-terminal myristoylation/palmitoylation and SH4-mediated membrane anchoring; also functions in lipid rafts/glycolipid-enriched microdomains, synaptic/postsynaptic compartments, and can participate in cytosolic or nuclear trafficking depending on phosphorylation state and binding partners (zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 1-2, peng2023fynemergingbiological pages 1-3, peng2023fynemergingbiological pages 14-14, peng2023fynemergingbiological pages 13-14)
Key pathways & roles—T cells	In canonical T-cell biology, Fyn contributes to proximal TCR signaling, including phosphorylation of TCR-associated components and cooperation/partial redundancy with Lck. New 2023–2024 work shows a TCR→Lck/Fyn→STAT3(Y705) axis that promotes TH17 differentiation and can shift fate away from FOXP3+ Treg cells. In engineered T cells, CD28-CAR signaling can proceed through Fyn rather than Lck, especially via the CD28 PYAP motif, with increased Fyn pY420 after CAR engagement and improved CAR-T functional profiles when Lck is absent (zhou2024theunderlyingmolecular pages 2-3, wu2023cd28cartcellactivation pages 3-5, wu2023cd28cartcellactivation pages 1-3, wu2023cd28cartcellactivation pages 5-9, qin2024tcrsignalinginduces pages 2-4, qin2024tcrsignalinginduces pages 1-2)
Key pathways & roles—CNS neurons/synapses	In neurons, Fyn regulates neurite outgrowth, microtubule dynamics, dendritic targeting, synaptic transmission, and plasticity. A major mechanistic role is at excitatory synapses, where SH2/SH3-mediated interactions help Fyn phosphorylate NMDAR subunits (including NR2B/NR2A-associated complexes), strengthening NMDA receptor signaling. Fyn also interacts functionally with Tau, linking kinase activity to synaptic dysfunction, excitotoxicity, and seizure-related signaling (zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 2-3, xu2024fynanimportant pages 3-4, putra2024enhancedfyntauand pages 1-3, putra2024enhancedfyntauand pages 14-15)
Key pathways & roles—microglia/neuroinflammation	Fyn is a central upstream kinase in microglial inflammatory activation, with reported links to PKCδ, NF-κB, inflammasome signaling, cytokine release, iNOS, and Kv1.3 regulation. Recent in vivo evidence from constitutively active FynY531F models places Stat3 downstream of pathogenic Fyn signaling in dopaminergic neurodegeneration and microglial activation; inhibition of Fyn/SFKs, Stat3, or NF-κB suppresses inflammatory transcriptional outputs and neuronal loss. In epilepsy models, Fyn activity also contributes to pro-convulsive microglial responses (xu2024fynanimportant pages 3-4, siddiqui2024stat3mediatesfyn pages 7-8, siddiqui2024stat3mediatesfyn pages 8-10, siddiqui2024stat3mediatesfyn pages 10-12, siddiqui2024stat3mediatesfyn pages 1-2, xu2024fynanimportant pages 2-3)
Key pathways & roles—oligodendrocytes/myelination	Fyn is strongly implicated in oligodendrocyte process elaboration, morphological differentiation, and CNS myelination. Mechanistically, it connects integrins/TrkB and other upstream cues to cytoskeletal remodeling pathways including Rho-family GTPases/p190RhoGAP, actin dynamics, and membrane-associated microtubule nucleation. Mouse loss-of-function evidence shows persistent forebrain myelin deficits and developmental oligodendrocyte abnormalities, supporting a primary pro-myelinating role; reviews also implicate Fyn in OPC migration and remyelination competence (xu2024fynanimportant pages 2-3, zhou2024theunderlyingmolecular pages 2-3, xu2024fynanimportant pages 1-2, zhou2024theunderlyingmolecular pages 8-8, zhou2024theunderlyingmolecular pages 7-7)
Pharmacology/applications	Fyn is mainly targeted with Src-family kinase inhibitors rather than highly selective Fyn-only drugs. Key agents include saracatinib/AZD0530 (highly specific SFK inhibitor; reported ~10 nM against FYN in review), PP1 (selective SFK inhibitor active against Fyn/Src/Lck), dasatinib/bosutinib/ponatinib (multi-kinase agents with SFK activity), and NXP900, a newer conformation-selective SFK inhibitor that stabilizes inactive Src-family kinases and shows ~1,000-fold selectivity over ABL. Applications span epilepsy/neuroinflammation models, chemoresistant TNBC, and early-phase solid-tumor trials (peng2023fynemergingbiological pages 8-10, xiong2024pharmacologicalinhibitionof pages 1-2, dash2024thesrcfamily pages 1-2, rao2023theeffectsof pages 1-2, egeland2024thesrcfamilyserves pages 1-2)
Quantitative recent findings	• CD28-CAR engagement produced a ~2-fold increase in Fyn pY420 after 30 min, and FYN knockout markedly reduced IL-2 output in CAR-Jurkat cells (wu2023cd28cartcellactivation pages 3-5). • In TH17 studies, Lck/Fyn inhibition nearly abolished STAT3 recruitment to TH17 loci and redirected differentiation toward Treg fate (qin2024tcrsignalinginduces pages 2-4). • In FynY531F neurodegeneration models, 10 µM saracatinib normalized Stat3-Y705 phosphorylation; 10 µM S3I-201 rescued dopaminergic neuron counts (P=0.99 vs untreated control) and reduced amoeboid microglia (P=0.0015) (siddiqui2024stat3mediatesfyn pages 7-8, siddiqui2024stat3mediatesfyn pages 8-10). • In chronic epilepsy, saracatinib reduced synaptosomal pSFK-Y416 (P=0.021), pTau-AT8 (P=0.035), pNR2B-Y1472 (P=0.043), decreased Fyn–tau complexes (P=0.007), reduced average convulsive seizures/day (P=0.0473), and lowered animals with ≥10 SRS/day from 8/12 to 1/10 (P=0.0115) (putra2024enhancedfyntauand pages 14-15). • In a mixed-sex kainate rat model, saracatinib caused a 42.17% reduction in glial scar size and significantly mitigated microgliosis (rao2023theeffectsof pages 12-14, rao2023theeffectsof pages 1-2). • In chemoresistant TNBC cohorts, high SFK expression (SRC/FYN/YES1) associated with faster progression: median disease-free interval 27 vs 105 months (egeland2024thesrcfamilyserves pages 1-2).

Table: This table summarizes the verified identity, biochemical properties, localization, pathway roles, and recent translational findings for mouse Fyn (UniProt P39688). It is useful as a compact evidence map linking core functional annotation to 2023–2024 mechanistic and application-focused studies.

9) References (URLs and publication dates)

The report’s key sources (all are already cited inline by context ID):
- Zhou et al., Frontiers in Cellular Neuroscience (Nov 2024). https://doi.org/10.3389/fncel.2024.1476856 (zhou2024theunderlyingmolecular pages 2-3)
- Xu et al., Frontiers in Pharmacology (Dec 2024). https://doi.org/10.3389/fphar.2024.1485919 (xu2024fynanimportant pages 1-2, xu2024fynanimportant pages 3-4)
- Qin et al., Journal of Experimental Medicine (Feb 2024). https://doi.org/10.1084/jem.20230683 (qin2024tcrsignalinginduces pages 2-4)
- Wu et al., Cell Reports Medicine (Feb 2023). https://doi.org/10.1016/j.xcrm.2023.100917 (wu2023cd28cartcellactivation pages 3-5)
- Putra et al., Brain Communications (Sep 2024). https://doi.org/10.1093/braincomms/fcae327 (putra2024enhancedfyntauand pages 14-15)
- Siddiqui et al., Disease Models & Mechanisms (Dec 2024). https://doi.org/10.1242/dmm.052011 (siddiqui2024stat3mediatesfyn pages 8-10)
- Dash et al., Journal of Biological Chemistry (Sep 2024). https://doi.org/10.1016/j.jbc.2024.107615 (dash2024thesrcfamily pages 1-2)
- Egeland et al., British Journal of Cancer (Oct 2024). https://doi.org/10.1038/s41416-024-02875-5 (egeland2024thesrcfamilyserves pages 1-2)
- Xiong et al., Frontiers in Pharmacology (Mar 2024). https://doi.org/10.3389/fphar.2024.1352730 (xiong2024pharmacologicalinhibitionof pages 1-2)
- Peng & Fu, Journal of Translational Medicine (Feb 2023). https://doi.org/10.1186/s12967-023-03930-0 (peng2023fynemergingbiological pages 1-3, peng2023fynemergingbiological pages 3-5, peng2023fynemergingbiological pages 8-10)

References

(zhou2024theunderlyingmolecular pages 2-3): Jiao Zhou, Xiang Lu, and Haichuan Wang. The underlying molecular mechanisms of fyn in neonatal hypoxic-ischaemic encephalopathy. Frontiers in Cellular Neuroscience, Nov 2024. URL: https://doi.org/10.3389/fncel.2024.1476856, doi:10.3389/fncel.2024.1476856. This article has 3 citations.
(xu2024fynanimportant pages 1-2): Chongxi Xu, Yi Tang, Xing Lu, and Ruiqi Chen. Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours. Frontiers in Pharmacology, Dec 2024. URL: https://doi.org/10.3389/fphar.2024.1485919, doi:10.3389/fphar.2024.1485919. This article has 4 citations.
(peng2023fynemergingbiological pages 1-3): SanFei Peng and Yang Fu. Fyn: emerging biological roles and potential therapeutic targets in cancer. Journal of Translational Medicine, Feb 2023. URL: https://doi.org/10.1186/s12967-023-03930-0, doi:10.1186/s12967-023-03930-0. This article has 79 citations and is from a peer-reviewed journal.
(peng2023fynemergingbiological pages 3-5): SanFei Peng and Yang Fu. Fyn: emerging biological roles and potential therapeutic targets in cancer. Journal of Translational Medicine, Feb 2023. URL: https://doi.org/10.1186/s12967-023-03930-0, doi:10.1186/s12967-023-03930-0. This article has 79 citations and is from a peer-reviewed journal.
(peng2023fynemergingbiological pages 13-14): SanFei Peng and Yang Fu. Fyn: emerging biological roles and potential therapeutic targets in cancer. Journal of Translational Medicine, Feb 2023. URL: https://doi.org/10.1186/s12967-023-03930-0, doi:10.1186/s12967-023-03930-0. This article has 79 citations and is from a peer-reviewed journal.
(qin2024tcrsignalinginduces pages 2-4): Zhen Qin, Ruining Wang, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, and Tao Xu. Tcr signaling induces stat3 phosphorylation to promote th17 cell differentiation. Journal of Experimental Medicine, Feb 2024. URL: https://doi.org/10.1084/jem.20230683, doi:10.1084/jem.20230683. This article has 65 citations and is from a highest quality peer-reviewed journal.
(qin2024tcrsignalinginduces pages 1-2): Zhen Qin, Ruining Wang, Ping Hou, Yuanyuan Zhang, Qianmu Yuan, Ying Wang, Yuedong Yang, and Tao Xu. Tcr signaling induces stat3 phosphorylation to promote th17 cell differentiation. Journal of Experimental Medicine, Feb 2024. URL: https://doi.org/10.1084/jem.20230683, doi:10.1084/jem.20230683. This article has 65 citations and is from a highest quality peer-reviewed journal.
(wu2023cd28cartcellactivation pages 3-5): Ling Wu, Joanna Brzostek, Previtha Dawn Sakthi Vale, Qianru Wei, Clara K.T. Koh, June Xu Hui Ong, Liang-zhe Wu, Jia Chi Tan, Yen Leong Chua, Jiawei Yap, Yuan Song, Vivian Jia Yi Tan, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, and Nicholas R.J. Gascoigne. Cd28-car-t cell activation through fyn kinase signaling rather than lck enhances therapeutic performance. Cell Reports Medicine, 4:100917, Feb 2023. URL: https://doi.org/10.1016/j.xcrm.2023.100917, doi:10.1016/j.xcrm.2023.100917. This article has 48 citations and is from a peer-reviewed journal.
(wu2023cd28cartcellactivation pages 1-3): Ling Wu, Joanna Brzostek, Previtha Dawn Sakthi Vale, Qianru Wei, Clara K.T. Koh, June Xu Hui Ong, Liang-zhe Wu, Jia Chi Tan, Yen Leong Chua, Jiawei Yap, Yuan Song, Vivian Jia Yi Tan, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, and Nicholas R.J. Gascoigne. Cd28-car-t cell activation through fyn kinase signaling rather than lck enhances therapeutic performance. Cell Reports Medicine, 4:100917, Feb 2023. URL: https://doi.org/10.1016/j.xcrm.2023.100917, doi:10.1016/j.xcrm.2023.100917. This article has 48 citations and is from a peer-reviewed journal.
(wu2023cd28cartcellactivation pages 5-9): Ling Wu, Joanna Brzostek, Previtha Dawn Sakthi Vale, Qianru Wei, Clara K.T. Koh, June Xu Hui Ong, Liang-zhe Wu, Jia Chi Tan, Yen Leong Chua, Jiawei Yap, Yuan Song, Vivian Jia Yi Tan, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, and Nicholas R.J. Gascoigne. Cd28-car-t cell activation through fyn kinase signaling rather than lck enhances therapeutic performance. Cell Reports Medicine, 4:100917, Feb 2023. URL: https://doi.org/10.1016/j.xcrm.2023.100917, doi:10.1016/j.xcrm.2023.100917. This article has 48 citations and is from a peer-reviewed journal.
(xu2024fynanimportant pages 3-4): Chongxi Xu, Yi Tang, Xing Lu, and Ruiqi Chen. Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours. Frontiers in Pharmacology, Dec 2024. URL: https://doi.org/10.3389/fphar.2024.1485919, doi:10.3389/fphar.2024.1485919. This article has 4 citations.
(siddiqui2024stat3mediatesfyn pages 7-8): Sahiba Siddiqui, Fang Liu, Anumantha G. Kanthasamy, and Maura McGrail. Stat3 mediates fyn kinase-driven dopaminergic neurodegeneration and microglia activation. Disease Models & Mechanisms, Dec 2024. URL: https://doi.org/10.1242/dmm.052011, doi:10.1242/dmm.052011. This article has 4 citations and is from a domain leading peer-reviewed journal.
(siddiqui2024stat3mediatesfyn pages 8-10): Sahiba Siddiqui, Fang Liu, Anumantha G. Kanthasamy, and Maura McGrail. Stat3 mediates fyn kinase-driven dopaminergic neurodegeneration and microglia activation. Disease Models & Mechanisms, Dec 2024. URL: https://doi.org/10.1242/dmm.052011, doi:10.1242/dmm.052011. This article has 4 citations and is from a domain leading peer-reviewed journal.
(siddiqui2024stat3mediatesfyn pages 10-12): Sahiba Siddiqui, Fang Liu, Anumantha G. Kanthasamy, and Maura McGrail. Stat3 mediates fyn kinase-driven dopaminergic neurodegeneration and microglia activation. Disease Models & Mechanisms, Dec 2024. URL: https://doi.org/10.1242/dmm.052011, doi:10.1242/dmm.052011. This article has 4 citations and is from a domain leading peer-reviewed journal.
(zhou2024theunderlyingmolecular pages 8-8): Jiao Zhou, Xiang Lu, and Haichuan Wang. The underlying molecular mechanisms of fyn in neonatal hypoxic-ischaemic encephalopathy. Frontiers in Cellular Neuroscience, Nov 2024. URL: https://doi.org/10.3389/fncel.2024.1476856, doi:10.3389/fncel.2024.1476856. This article has 3 citations.
(zhou2024theunderlyingmolecular pages 7-7): Jiao Zhou, Xiang Lu, and Haichuan Wang. The underlying molecular mechanisms of fyn in neonatal hypoxic-ischaemic encephalopathy. Frontiers in Cellular Neuroscience, Nov 2024. URL: https://doi.org/10.3389/fncel.2024.1476856, doi:10.3389/fncel.2024.1476856. This article has 3 citations.
(putra2024enhancedfyntauand pages 14-15): Marson Putra, Nikhil S Rao, Cara Gardner, Guanghao Liu, Jordan Trommater, Michael Bunney, Meghan Gage, Alexander G Bassuk, Marco Hefti, Gloria Lee, and Thimmasettappa Thippeswamy. Enhanced fyn-tau and nr2b-psd95 interactions in epileptic foci in experimental models and human epilepsy. Brain Communications, Sep 2024. URL: https://doi.org/10.1093/braincomms/fcae327, doi:10.1093/braincomms/fcae327. This article has 16 citations and is from a peer-reviewed journal.
(peng2023fynemergingbiological pages 8-10): SanFei Peng and Yang Fu. Fyn: emerging biological roles and potential therapeutic targets in cancer. Journal of Translational Medicine, Feb 2023. URL: https://doi.org/10.1186/s12967-023-03930-0, doi:10.1186/s12967-023-03930-0. This article has 79 citations and is from a peer-reviewed journal.
(xiong2024pharmacologicalinhibitionof pages 1-2): Chongxiang Xiong, Jin Deng, Xin Wang, Qidi Hou, and Shougang Zhuang. Pharmacological inhibition of src family kinases attenuates hyperuricemic nephropathy. Frontiers in Pharmacology, Mar 2024. URL: https://doi.org/10.3389/fphar.2024.1352730, doi:10.3389/fphar.2024.1352730. This article has 4 citations.
(dash2024thesrcfamily pages 1-2): Sweta Dash, Sabrina Hanson, Ben King, Katherine Nyswaner, Kelcie Foss, Noelle Tesi, Mungo J.B. Harvey, Saúl A. Navarro-Marchal, Allison Woods, Enrique Poradosu, Asier Unciti-Broceta, Neil O. Carragher, and John Brognard. The src family kinase inhibitor nxp900 demonstrates potent antitumor activity in squamous cell carcinomas. Journal of Biological Chemistry, 300:107615, Sep 2024. URL: https://doi.org/10.1016/j.jbc.2024.107615, doi:10.1016/j.jbc.2024.107615. This article has 7 citations and is from a domain leading peer-reviewed journal.
(egeland2024thesrcfamilyserves pages 1-2): Eivind Valen Egeland, Kotryna Seip, Eleni Skourti, Geir Frode Øy, Solveig J. Pettersen, Abhilash D. Pandya, Maria A. Dahle, Mads H. Haugen, Alexander Kristian, Sigve Nakken, Olav Engebraaten, Gunhild M. Mælandsmo, and Lina Prasmickaite. The src-family serves as a therapeutic target in triple negative breast cancer with acquired resistance to chemotherapy. British Journal of Cancer, 131:1656-1667, Oct 2024. URL: https://doi.org/10.1038/s41416-024-02875-5, doi:10.1038/s41416-024-02875-5. This article has 10 citations and is from a domain leading peer-reviewed journal.
(rao2023theeffectsof pages 12-14): Nikhil S. Rao, Marson Putra, Christina Meyer, Aida Almanza, and Thimmasettappa Thippeswamy. The effects of src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy. Frontiers in Molecular Neuroscience, Nov 2023. URL: https://doi.org/10.3389/fnmol.2023.1294514, doi:10.3389/fnmol.2023.1294514. This article has 12 citations.
(putra2024enhancedfyntauand media 37b3b928): Marson Putra, Nikhil S Rao, Cara Gardner, Guanghao Liu, Jordan Trommater, Michael Bunney, Meghan Gage, Alexander G Bassuk, Marco Hefti, Gloria Lee, and Thimmasettappa Thippeswamy. Enhanced fyn-tau and nr2b-psd95 interactions in epileptic foci in experimental models and human epilepsy. Brain Communications, Sep 2024. URL: https://doi.org/10.1093/braincomms/fcae327, doi:10.1093/braincomms/fcae327. This article has 16 citations and is from a peer-reviewed journal.
(putra2024enhancedfyntauand media b037ed8c): Marson Putra, Nikhil S Rao, Cara Gardner, Guanghao Liu, Jordan Trommater, Michael Bunney, Meghan Gage, Alexander G Bassuk, Marco Hefti, Gloria Lee, and Thimmasettappa Thippeswamy. Enhanced fyn-tau and nr2b-psd95 interactions in epileptic foci in experimental models and human epilepsy. Brain Communications, Sep 2024. URL: https://doi.org/10.1093/braincomms/fcae327, doi:10.1093/braincomms/fcae327. This article has 16 citations and is from a peer-reviewed journal.
(peng2023fynemergingbiological pages 14-14): SanFei Peng and Yang Fu. Fyn: emerging biological roles and potential therapeutic targets in cancer. Journal of Translational Medicine, Feb 2023. URL: https://doi.org/10.1186/s12967-023-03930-0, doi:10.1186/s12967-023-03930-0. This article has 79 citations and is from a peer-reviewed journal.
(xu2024fynanimportant pages 2-3): Chongxi Xu, Yi Tang, Xing Lu, and Ruiqi Chen. Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours. Frontiers in Pharmacology, Dec 2024. URL: https://doi.org/10.3389/fphar.2024.1485919, doi:10.3389/fphar.2024.1485919. This article has 4 citations.
(putra2024enhancedfyntauand pages 1-3): Marson Putra, Nikhil S Rao, Cara Gardner, Guanghao Liu, Jordan Trommater, Michael Bunney, Meghan Gage, Alexander G Bassuk, Marco Hefti, Gloria Lee, and Thimmasettappa Thippeswamy. Enhanced fyn-tau and nr2b-psd95 interactions in epileptic foci in experimental models and human epilepsy. Brain Communications, Sep 2024. URL: https://doi.org/10.1093/braincomms/fcae327, doi:10.1093/braincomms/fcae327. This article has 16 citations and is from a peer-reviewed journal.
(siddiqui2024stat3mediatesfyn pages 1-2): Sahiba Siddiqui, Fang Liu, Anumantha G. Kanthasamy, and Maura McGrail. Stat3 mediates fyn kinase-driven dopaminergic neurodegeneration and microglia activation. Disease Models & Mechanisms, Dec 2024. URL: https://doi.org/10.1242/dmm.052011, doi:10.1242/dmm.052011. This article has 4 citations and is from a domain leading peer-reviewed journal.
(rao2023theeffectsof pages 1-2): Nikhil S. Rao, Marson Putra, Christina Meyer, Aida Almanza, and Thimmasettappa Thippeswamy. The effects of src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy. Frontiers in Molecular Neuroscience, Nov 2023. URL: https://doi.org/10.3389/fnmol.2023.1294514, doi:10.3389/fnmol.2023.1294514. This article has 12 citations.

Citations

xu2024fynanimportant pages 1-2
xu2024fynanimportant pages 3-4
putra2024enhancedfyntauand pages 14-15
peng2023fynemergingbiological pages 8-10
xiong2024pharmacologicalinhibitionof pages 1-2
dash2024thesrcfamily pages 1-2
egeland2024thesrcfamilyserves pages 1-2
rao2023theeffectsof pages 12-14
qin2024tcrsignalinginduces pages 2-4
zhou2024theunderlyingmolecular pages 2-3
peng2023fynemergingbiological pages 1-3
peng2023fynemergingbiological pages 3-5
peng2023fynemergingbiological pages 13-14
qin2024tcrsignalinginduces pages 1-2
zhou2024theunderlyingmolecular pages 8-8
zhou2024theunderlyingmolecular pages 7-7
peng2023fynemergingbiological pages 14-14
xu2024fynanimportant pages 2-3
putra2024enhancedfyntauand pages 1-3
rao2023theeffectsof pages 1-2
https://doi.org/10.3389/fncel.2024.1476856
https://doi.org/10.3389/fphar.2024.1485919
https://doi.org/10.1084/jem.20230683
https://doi.org/10.1016/j.xcrm.2023.100917
https://doi.org/10.1093/braincomms/fcae327
https://doi.org/10.1242/dmm.052011
https://doi.org/10.1016/j.jbc.2024.107615
https://doi.org/10.1038/s41416-024-02875-5
https://doi.org/10.3389/fphar.2024.1352730
https://doi.org/10.1186/s12967-023-03930-0
https://doi.org/10.3389/fncel.2024.1476856,
https://doi.org/10.3389/fphar.2024.1485919,
https://doi.org/10.1186/s12967-023-03930-0,
https://doi.org/10.1084/jem.20230683,
https://doi.org/10.1016/j.xcrm.2023.100917,
https://doi.org/10.1242/dmm.052011,
https://doi.org/10.1093/braincomms/fcae327,
https://doi.org/10.3389/fphar.2024.1352730,
https://doi.org/10.1016/j.jbc.2024.107615,
https://doi.org/10.1038/s41416-024-02875-5,
https://doi.org/10.3389/fnmol.2023.1294514,

Bioreason Rl Review

(Fyn-bioreason-rl-review.md)

BioReason-Pro RL Review: Fyn (mouse)

Source: Fyn-deep-research-bioreason-rl.md

Correctness: 5/5
Completeness: 3/5

Functional Summary Review

The BioReason functional summary is accurate but generic:

A cytoplasmic, non-receptor tyrosine kinase that uses SH3- and SH2-mediated docking to assemble on membrane-proximal signaling complexes and phosphorylate tyrosine residues via a conserved catalytic core. By coupling high-affinity substrate targeting with ATP-fueled catalysis, it propagates intracellular signaling pathways that regulate adhesion, cytoskeletal remodeling, and survival decisions in mouse cells.

This correctly identifies the SH3-SH2-kinase domain architecture, the non-receptor tyrosine kinase identity (GO:0004713), and the cytoplasmic localization. The mention of adhesion and cytoskeletal remodeling is appropriate for a Src-family kinase.

However, the summary is essentially a generic description that would apply to any Src-family kinase (Src, Fyn, Yes, Lck, Lyn, etc.) without distinguishing Fyn-specific biology. Fyn has well-characterized specific roles in: (1) T-cell receptor signaling (the Fyn-T isoform), (2) myelination and oligodendrocyte development, (3) tau phosphorylation and Alzheimer's disease pathogenesis, (4) NMDA receptor regulation at synapses, and (5) lipid raft-associated signaling. None of these are mentioned. The curated review lists GO:0048156 (tau protein binding) and GO:0043014 (alpha-tubulin binding) as specific MF annotations.

The functional summary also omits the N-terminal myristoylation/palmitoylation that targets Fyn to membrane rafts, which is a distinctive feature compared to Src.

Comparison with interpro2go:

The curated review has one GO_REF:0000002 annotation: GO:0005524 (ATP binding). BioReason's summary describes ATP-dependent catalysis consistent with this but provides no additional interpro2go-level insight. The summary largely mirrors what interpro2go would predict from the SH3-SH2-kinase architecture (protein tyrosine kinase activity, ATP binding, intracellular signal transduction) without adding Fyn-specific biology. This is a case where BioReason is essentially recapitulating domain-based predictions dressed up in narrative form.

Notes on thinking trace

The trace correctly identifies the Fyn/Yrk-specific SH3 and SH2 domain annotations (IPR035750, IPR047924) but does not leverage this family-level specificity in the functional summary. The mechanistic model of SH3/SH2-guided docking followed by kinase catalysis is standard textbook Src-family kinase biology.

📄 View Raw YAML

id: P39688
gene_symbol: Fyn
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: Fyn is a Src-family non-receptor tyrosine kinase with SH3, SH2, and catalytic
  kinase domains. It localizes to cytosol and membrane/lipid-raft signaling platforms and
  phosphorylates tyrosine residues in immune receptor, adhesion, reelin, synaptic, axon guidance,
  and growth-factor-associated signaling pathways.
alternative_products:
- name: 1 (B)
  id: P39688-1
- name: 2 (T)
  id: P39688-2
  sequence_note: VSP_024111, VSP_024112
existing_annotations:
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: plasma membrane is directly supported as part of the core molecular function,
      direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030154
    label: cell differentiation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: cell differentiation is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0007169
    label: cell surface receptor protein tyrosine kinase signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: Fyn participates in cell surface receptor protein tyrosine kinase signaling pathways, but this is one of several receptor/signaling contexts for the Src-family kinase rather than the sole core role.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role. GO:0007169 is more specific than intracellular signal transduction and should not be replaced by its broader parent.
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is directly supported
      as part of the core molecular function, direct pathway role, or primary localization
      of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: T cell receptor signaling pathway is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity
      is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity
      for this gene.
    action: MODIFY
    reason: Use a more specific GO term supported by the gene product role
    proposed_replacement_terms:
    - id: GO:0004715
      label: non-membrane spanning protein tyrosine kinase activity
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is directly supported
      as part of the core molecular function, direct pathway role, or primary localization
      of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: ATP binding is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: nucleus is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: cytoplasm is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: plasma membrane is directly supported as part of the core molecular function,
      direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043204
    label: perikaryon
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: perikaryon is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10077576
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12372285
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15102471
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16316995
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16847311
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25417160
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27474268
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7730365
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8631859
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9535845
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9890970
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0000304
    label: response to singlet oxygen
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: response to singlet oxygen is biologically plausible for Fyn but represents a
      context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0001664
    label: G protein-coupled receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: G protein-coupled receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0003015
    label: heart process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: heart process is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: mitochondrion is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005768
    label: endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: endosome is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0007216
    label: G protein-coupled glutamate receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: G protein-coupled glutamate receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0009410
    label: response to xenobiotic stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: response to xenobiotic stimulus is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0010730
    label: negative regulation of hydrogen peroxide biosynthetic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of hydrogen peroxide biosynthetic process is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phospholipase activator activity is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030101
    label: natural killer cell activation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: natural killer cell activation is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: dendrite is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0031802
    label: type 5 metabotropic glutamate receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: type 5 metabotropic glutamate receptor binding is biologically plausible for
      Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: intracellular signal transduction is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042220
    label: response to cocaine
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: response to cocaine is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042608
    label: T cell receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: T cell receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042609
    label: CD4 receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: CD4 receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042610
    label: CD8 receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: CD8 receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: identical protein binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phospholipase binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043524
    label: negative regulation of neuron apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of neuron apoptotic process is biologically plausible for
      Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043548
    label: phosphatidylinositol 3-kinase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phosphatidylinositol 3-kinase binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein-containing complex binding is too generic or indirect for Fyn; the evidence
      supports a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: membrane raft is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: ephrin receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: perinuclear region of cytoplasm is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: T cell receptor signaling pathway is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of T cell receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of T cell activation is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0051428
    label: peptide hormone receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: peptide hormone receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to hydrogen peroxide is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0070851
    label: growth factor receptor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: growth factor receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0071363
    label: cellular response to growth factor stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to growth factor stimulus is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0071375
    label: cellular response to peptide hormone stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to peptide hormone stimulus is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097038
    label: perinuclear endoplasmic reticulum
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: perinuclear endoplasmic reticulum is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: scaffold protein binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097718
    label: disordered domain specific binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: disordered domain specific binding is too generic or indirect for Fyn; the evidence
      supports a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: glutamatergic synapse is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0099092
    label: postsynaptic density, intracellular component
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: postsynaptic density, intracellular component is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1902176
    label: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of oxidative stress-induced intrinsic apoptotic signaling
      pathway is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to amyloid-beta is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1905232
    label: cellular response to L-glutamate
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to L-glutamate is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1905430
    label: cellular response to glycine
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to glycine is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:2001240
    label: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
      is biologically plausible for Fyn but represents a context-specific pathway, localization,
      interaction, phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0003015
    label: heart process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: heart process is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is directly supported
      as part of the core molecular function, direct pathway role, or primary localization
      of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005768
    label: endosome
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: endosome is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: plasma membrane is directly supported as part of the core molecular function,
      direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0007216
    label: G protein-coupled glutamate receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: G protein-coupled glutamate receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0016004
    label: phospholipase activator activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phospholipase activator activity is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030101
    label: natural killer cell activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: natural killer cell activation is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: dendrite is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: intracellular signal transduction is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: identical protein binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043274
    label: phospholipase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phospholipase binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: membrane raft is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0046875
    label: ephrin receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ephrin receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: T cell receptor signaling pathway is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of T cell receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of T cell activation is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0070851
    label: growth factor receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: growth factor receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: scaffold protein binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097718
    label: disordered domain specific binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: disordered domain specific binding is too generic or indirect for Fyn; the evidence
      supports a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to amyloid-beta is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0046777
    label: protein autophosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein autophosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0000304
    label: response to singlet oxygen
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: response to singlet oxygen is biologically plausible for Fyn but represents a
      context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity
      is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity
      for this gene.
    action: MODIFY
    reason: Use a more specific GO term supported by the gene product role
    proposed_replacement_terms:
    - id: GO:0004715
      label: non-membrane spanning protein tyrosine kinase activity
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005102
    label: signaling receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: signaling receptor binding is too generic or indirect for Fyn; the evidence supports
      a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: nucleus is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: mitochondrion is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0010730
    label: negative regulation of hydrogen peroxide biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of hydrogen peroxide biosynthetic process is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0019899
    label: enzyme binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: enzyme binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendrite is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0031802
    label: type 5 metabotropic glutamate receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: type 5 metabotropic glutamate receptor binding is biologically plausible for
      Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: intracellular signal transduction is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042608
    label: T cell receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: T cell receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042609
    label: CD4 receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: CD4 receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042610
    label: CD8 receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: CD8 receptor binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043524
    label: negative regulation of neuron apoptotic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of neuron apoptotic process is biologically plausible for
      Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043548
    label: phosphatidylinositol 3-kinase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: phosphatidylinositol 3-kinase binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein-containing complex binding is too generic or indirect for Fyn; the evidence
      supports a more specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: perinuclear region of cytoplasm is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0051428
    label: peptide hormone receptor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: peptide hormone receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0051897
    label: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal
      transduction is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0070301
    label: cellular response to hydrogen peroxide
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cellular response to hydrogen peroxide is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097038
    label: perinuclear endoplasmic reticulum
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: perinuclear endoplasmic reticulum is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: glutamatergic synapse is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0099092
    label: postsynaptic density, intracellular component
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: postsynaptic density, intracellular component is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1902176
    label: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of oxidative stress-induced intrinsic apoptotic signaling
      pathway is biologically plausible for Fyn but represents a context-specific pathway,
      localization, interaction, phenotype, or downstream response rather than the primary
      core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1905232
    label: cellular response to L-glutamate
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cellular response to L-glutamate is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1905430
    label: cellular response to glycine
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cellular response to glycine is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:2001240
    label: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
      is biologically plausible for Fyn but represents a context-specific pathway, localization,
      interaction, phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9507006
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: non-membrane spanning protein tyrosine kinase activity is directly supported
      as part of the core molecular function, direct pathway role, or primary localization
      of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050860
    label: negative regulation of T cell receptor signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: negative regulation of T cell receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: negative regulation of T cell activation is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IMP
  original_reference_id: PMID:27525436
  review:
    summary: intracellular signal transduction is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: intracellular signal transduction is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1900449
    label: regulation of glutamate receptor signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: regulation of glutamate receptor signaling pathway is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:16709819
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928613
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-983702
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420398
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0016525
    label: negative regulation of angiogenesis
  evidence_type: IMP
  original_reference_id: PMID:10613822
  review:
    summary: negative regulation of angiogenesis is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12526739
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0038026
    label: reelin-mediated signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:12526739
  review:
    summary: reelin-mediated signaling pathway is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IMP
  original_reference_id: PMID:1361685
  review:
    summary: modulation of chemical synaptic transmission is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IDA
  original_reference_id: PMID:1361685
  review:
    summary: modulation of chemical synaptic transmission is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0098685
    label: Schaffer collateral - CA1 synapse
  evidence_type: IMP
  original_reference_id: PMID:1361685
  review:
    summary: Schaffer collateral - CA1 synapse is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0098685
    label: Schaffer collateral - CA1 synapse
  evidence_type: IDA
  original_reference_id: PMID:1361685
  review:
    summary: Schaffer collateral - CA1 synapse is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0010467
    label: gene expression
  evidence_type: IGI
  original_reference_id: PMID:31461442
  review:
    summary: gene expression is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:23169819
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0090314
    label: positive regulation of protein targeting to membrane
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: positive regulation of protein targeting to membrane is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1902951
    label: negative regulation of dendritic spine maintenance
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: negative regulation of dendritic spine maintenance is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1904645
    label: response to amyloid-beta
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: response to amyloid-beta is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1905664
    label: regulation of calcium ion import across plasma membrane
  evidence_type: IGI
  original_reference_id: PMID:22820466
  review:
    summary: regulation of calcium ion import across plasma membrane is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:10557075
  review:
    summary: This PMID does not provide direct evidence for Fyn plasma membrane localization;
      it localizes AK1beta rather than establishing the annotated location for Fyn.
    action: REMOVE
    reason: Cited evidence does not support this gene-product annotation
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:28598420
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:28598420
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0043014
    label: alpha-tubulin binding
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: alpha-tubulin binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0048156
    label: tau protein binding
  evidence_type: IPI
  original_reference_id: PMID:11826099
  review:
    summary: tau protein binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12681493
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:12681493
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:26901312
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26901312
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22685302
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0003015
    label: heart process
  evidence_type: IGI
  original_reference_id: PMID:27525436
  review:
    summary: heart process is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0044297
    label: cell body
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: cell body is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0045121
    label: membrane raft
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: membrane raft is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0097386
    label: glial cell projection
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: glial cell projection is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-1433273
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-2395436
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928613
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-3928635
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9605258
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680646
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9680706
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682158
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682182
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9682572
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763891
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763892
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9763903
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9764150
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9817994
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9818009
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-983702
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420388
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420398
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-421136
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-421138
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9032771
  review:
    summary: plasma membrane is directly supported as part of the core molecular function,
      direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20655099
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IMP
  original_reference_id: PMID:20655099
  review:
    summary: postsynaptic density is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IMP
  original_reference_id: PMID:20655099
  review:
    summary: dendrite is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8551236
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:24627473
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0031397
    label: negative regulation of protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:24627473
  review:
    summary: negative regulation of protein ubiquitination is biologically plausible for Fyn
      but represents a context-specific pathway, localization, interaction, phenotype, or
      downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0071560
    label: cellular response to transforming growth factor beta stimulus
  evidence_type: IGI
  original_reference_id: PMID:21829547
  review:
    summary: cellular response to transforming growth factor beta stimulus is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005768
    label: endosome
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: endosome is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005884
    label: actin filament
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: actin filament is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0036120
    label: cellular response to platelet-derived growth factor stimulus
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: cellular response to platelet-derived growth factor stimulus is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0071944
    label: cell periphery
  evidence_type: IDA
  original_reference_id: PMID:17623777
  review:
    summary: cell periphery is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IGI
  original_reference_id: PMID:23169819
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0001664
    label: G protein-coupled receptor binding
  evidence_type: IPI
  original_reference_id: PMID:23169819
  review:
    summary: G protein-coupled receptor binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1900182
    label: positive regulation of protein localization to nucleus
  evidence_type: IMP
  original_reference_id: PMID:20142099
  review:
    summary: positive regulation of protein localization to nucleus is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11711534
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10872802
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:20142099
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:1900182
    label: positive regulation of protein localization to nucleus
  evidence_type: IDA
  original_reference_id: PMID:20142099
  review:
    summary: positive regulation of protein localization to nucleus is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042531
    label: positive regulation of tyrosine phosphorylation of STAT protein
  evidence_type: IMP
  original_reference_id: PMID:23438599
  review:
    summary: positive regulation of tyrosine phosphorylation of STAT protein is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9185665
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0010976
    label: positive regulation of neuron projection development
  evidence_type: IGI
  original_reference_id: PMID:18354028
  review:
    summary: positive regulation of neuron projection development is biologically plausible
      for Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8196616
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9655502
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0048813
    label: dendrite morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:12372285
  review:
    summary: dendrite morphogenesis is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:17923684
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17923684
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:17923684
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:17923684
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9177270
  review:
    summary: cell surface receptor signaling pathway is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0008360
    label: regulation of cell shape
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: regulation of cell shape is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:10872802
  review:
    summary: This PMID reports APS phosphorylation after cytokine or BCR stimulation but does
      not identify Fyn as the kinase responsible for that phosphorylation.
    action: REMOVE
    reason: Cited evidence does not support this gene-product annotation
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8196616
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0044325
    label: transmembrane transporter binding
  evidence_type: IPI
  original_reference_id: PMID:12538589
  review:
    summary: transmembrane transporter binding is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:20978343
  review:
    summary: negative regulation of gene expression is biologically plausible for Fyn but
      represents a context-specific pathway, localization, interaction, phenotype, or downstream
      response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:16841086
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042177
    label: negative regulation of protein catabolic process
  evidence_type: IMP
  original_reference_id: PMID:16841086
  review:
    summary: negative regulation of protein catabolic process is biologically plausible for
      Fyn but represents a context-specific pathway, localization, interaction, phenotype,
      or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420382
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-420394
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-420386
  review:
    summary: cytosol is directly supported as part of the core molecular function, direct
      pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:7799925
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:9381182
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0045471
    label: response to ethanol
  evidence_type: IGI
  original_reference_id: PMID:9381182
  review:
    summary: response to ethanol is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: peptidyl-tyrosine phosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0046777
    label: protein autophosphorylation
  evidence_type: IDA
  original_reference_id: PMID:8175795
  review:
    summary: protein autophosphorylation is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050798
    label: activated T cell proliferation
  evidence_type: IMP
  original_reference_id: PMID:1516132
  review:
    summary: activated T cell proliferation is biologically plausible for Fyn but represents
      a context-specific pathway, localization, interaction, phenotype, or downstream response
      rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:16190898
  review:
    summary: The annotation captures a real aspect of Fyn biology, but protein phosphorylation
      is less precise than GO:0018108 peptidyl-tyrosine phosphorylation for this gene.
    action: MODIFY
    reason: Use a more specific GO term supported by the gene product role
    proposed_replacement_terms:
    - id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:9892651
  review:
    summary: The annotation captures a real aspect of Fyn biology, but protein phosphorylation
      is less precise than GO:0018108 peptidyl-tyrosine phosphorylation for this gene.
    action: MODIFY
    reason: Use a more specific GO term supported by the gene product role
    proposed_replacement_terms:
    - id: GO:0018108
      label: peptidyl-tyrosine phosphorylation
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0050966
    label: detection of mechanical stimulus involved in sensory perception of pain
  evidence_type: IMP
  original_reference_id: PMID:16190898
  review:
    summary: detection of mechanical stimulus involved in sensory perception of pain is biologically
      plausible for Fyn but represents a context-specific pathway, localization, interaction,
      phenotype, or downstream response rather than the primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:10872802
  review:
    summary: This PMID does not directly assay or establish Fyn protein tyrosine kinase activity;
      it reports APS phosphorylation without identifying Fyn as the responsible kinase.
    action: REMOVE
    reason: Cited evidence does not support this gene-product annotation
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10713104
  review:
    summary: protein binding is too generic or indirect for Fyn; the evidence supports a more
      specific signaling, catalytic, adaptor, or localization role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Overly broad or uninformative relative to the supported core function
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0001764
    label: neuron migration
  evidence_type: IMP
  original_reference_id: PMID:15073522
  review:
    summary: neuron migration is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030900
    label: forebrain development
  evidence_type: IMP
  original_reference_id: PMID:15073522
  review:
    summary: forebrain development is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0001764
    label: neuron migration
  evidence_type: IGI
  original_reference_id: PMID:16162939
  review:
    summary: neuron migration is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0030900
    label: forebrain development
  evidence_type: IGI
  original_reference_id: PMID:16162939
  review:
    summary: forebrain development is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004713
    label: protein tyrosine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8196616
  review:
    summary: protein tyrosine kinase activity is directly supported as part of the core molecular
      function, direct pathway role, or primary localization of Fyn.
    action: ACCEPT
    reason: Directly supported core function, process, or location
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: The annotation captures a real aspect of Fyn biology, but protein kinase activity
      is less precise than GO:0004715 non-membrane spanning protein tyrosine kinase activity
      for this gene.
    action: MODIFY
    reason: Use a more specific GO term supported by the gene product role
    proposed_replacement_terms:
    - id: GO:0004715
      label: non-membrane spanning protein tyrosine kinase activity
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0015631
    label: tubulin binding
  evidence_type: IDA
  original_reference_id: PMID:11826099
  review:
    summary: tubulin binding is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
- term:
    id: GO:0042552
    label: myelination
  evidence_type: TAS
  original_reference_id: PMID:11826099
  review:
    summary: myelination is biologically plausible for Fyn but represents a context-specific
      pathway, localization, interaction, phenotype, or downstream response rather than the
      primary core function.
    action: KEEP_AS_NON_CORE
    reason: Supported secondary or context-specific role
    supported_by:
    - reference_id: UniProt:P39688
      supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
        regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
        cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
        ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
        SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid
        rafts.'
    - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
      supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
        context, and evidence synthesis.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary
    mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat
    orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs
    using Ensembl Compara
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human
    orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10077576
  title: 'Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src
    substrate during mitosis.'
  findings: []
- id: PMID:10557075
  title: wt p53 dependent expression of a membrane-associated isoform of adenylate kinase.
  findings: []
- id: PMID:10613822
  title: Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.
  findings: []
- id: PMID:10713104
  title: HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation
    of erythroid cells.
  findings: []
- id: PMID:10872802
  title: Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
  findings: []
- id: PMID:11711534
  title: '''Srcasm: a novel Src activating and signaling molecule.'
  findings: []
- id: PMID:11826099
  title: Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with
    the cytoskeletal protein tau.
  findings: []
- id: PMID:12372285
  title: Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of
    dendrite orientation in cerebral cortex.
  findings: []
- id: PMID:12526739
  title: Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.
  findings: []
- id: PMID:12538589
  title: Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation.
    SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its
    response to hypotonic stress.
  findings: []
- id: PMID:12681493
  title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast
    cells.
  findings: []
- id: PMID:1361685
  title: Impaired long-term potentiation, spatial learning, and hippocampal development in
    fyn mutant mice.
  findings: []
- id: PMID:15073522
  title: Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.
  findings: []
- id: PMID:15102471
  title: Bioinformatics and cellular signaling.
  findings: []
- id: PMID:1516132
  title: Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.
  findings: []
- id: PMID:16162939
  title: Absence of Fyn and Src causes a reeler-like phenotype.
  findings: []
- id: PMID:16190898
  title: Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential
    for maintenance of neuropathic pain.
  findings: []
- id: PMID:16316995
  title: IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine
    1-phosphate requires Fyn kinase and contributes to mast cell responses.
  findings: []
- id: PMID:16709819
  title: Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
  findings: []
- id: PMID:16841086
  title: Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating
    Akt, preventing its apoptotic cleavage and promoting cell survival.
  findings: []
- id: PMID:16847311
  title: 'Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled
    by engagement of the SLAM receptor.'
  findings: []
- id: PMID:17623777
  title: The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by
    palmitoylation and distinct RhoB/RhoD endosome requirements.
  findings: []
- id: PMID:17923684
  title: Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
  findings: []
- id: PMID:18354028
  title: Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase
    and contributes to postnatal CNS development in vivo.
  findings: []
- id: PMID:20142099
  title: Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine
    phosphorylation of LKB1.
  findings: []
- id: PMID:20655099
  title: Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse
    models.
  findings: []
- id: PMID:20978343
  title: CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.
  findings: []
- id: PMID:21829547
  title: Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation
    and PAI-1 expression.
  findings: []
- id: PMID:22685302
  title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C)
    in netrin-1-mediated growth cone collapse.
  findings: []
- id: PMID:22820466
  title: Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to
    impair neurons.
  findings: []
- id: PMID:23169819
  title: GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
  findings: []
- id: PMID:23438599
  title: Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.
  findings: []
- id: PMID:24627473
  title: Phosphorylation of the antiviral protein interferon-inducible transmembrane protein
    3 (IFITM3) dually regulates its endocytosis and ubiquitination.
  findings: []
- id: PMID:25417160
  title: A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and
    metastasis.
  findings: []
- id: PMID:26901312
  title: A Central Nervous System-Dependent Intron-Embedded Gene Encodes a Novel Murine Fyn
    Binding Protein.
  findings: []
- id: PMID:27474268
  title: Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies
    CD5 as a key regulator of TCR-induced ubiquitylation.
  findings: []
- id: PMID:27525436
  title: Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.
  findings: []
- id: PMID:28598420
  title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate
    receptors.
  findings: []
- id: PMID:31461442
  title: A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial
    cells and endothelial cells.
  findings: []
- id: PMID:7730365
  title: Sequence requirements for binding of Src family tyrosine kinases to activated growth
    factor receptors.
  findings: []
- id: PMID:7799925
  title: Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src
    family tyrosine kinases, Grb2, and phospholipase C gamma-1.
  findings: []
- id: PMID:8175795
  title: CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.
  findings: []
- id: PMID:8196616
  title: 'Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining
    the nature of a signalling motif.'
  findings: []
- id: PMID:8551236
  title: Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl
    in T lymphocytes.
  findings: []
- id: PMID:8631859
  title: The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during
    insulin stimulation.
  findings: []
- id: PMID:9177270
  title: 'Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional
    and physical association with src-kinases.'
  findings: []
- id: PMID:9185665
  title: Molecular cloning of Fyn-associated molecules in the mouse central nervous system.
  findings: []
- id: PMID:9381182
  title: 'Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.'
  findings: []
- id: PMID:9507006
  title: Identification of sirm, a novel insulin-regulated SH3 binding protein that associates
    with Grb-2 and FYN.
  findings: []
- id: PMID:9535845
  title: Physical and functional interactions between receptor-like protein-tyrosine phosphatase
    alpha and p59fyn.
  findings: []
- id: PMID:9655502
  title: Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic
    complex.
  findings: []
- id: PMID:9890970
  title: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for
    phosphatidylinositol 3-kinase.
  findings: []
- id: PMID:9892651
  title: PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate
    receptor subunit NR2A.
  findings: []
- id: Reactome:R-MMU-1433273
  title: Interaction of Src kinases with c-Kit
  findings: []
- id: Reactome:R-MMU-2395436
  title: Phosphorylation of DAP12
  findings: []
- id: Reactome:R-MMU-3928613
  title: Fyn phosphorylates Nmdar2b
  findings: []
- id: Reactome:R-MMU-3928635
  title: Ephb2 bind Nmdar
  findings: []
- id: Reactome:R-MMU-420382
  title: Phosphorylation of FAK by Src kinases
  findings: []
- id: Reactome:R-MMU-420394
  title: Recruitment of FAK to NCAM1:Fyn in lipid rafts
  findings: []
- id: Reactome:R-MMU-9032771
  title: Dock3 binds Fyn associated with Ntrk2
  findings: []
- id: Reactome:R-MMU-9605258
  title: Active Flt3 binds Fyn
  findings: []
- id: Reactome:R-MMU-9680646
  title: Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2),
    Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2)  bind p-8Y-Csf1r
    and are activated
  findings: []
- id: Reactome:R-MMU-9680706
  title: Csf1r trans-autophosphorylates on multiple tyrosine residues
  findings: []
- id: Reactome:R-MMU-9682158
  title: Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate
    and 1,2-diacylglycerol
  findings: []
- id: Reactome:R-MMU-9682182
  title: Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
  findings: []
- id: Reactome:R-MMU-9682572
  title: Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
  findings: []
- id: Reactome:R-MMU-9763891
  title: Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl
  findings: []
- id: Reactome:R-MMU-9763892
  title: p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
  findings: []
- id: Reactome:R-MMU-9763903
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9764150
  title: Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r
    dimer:SFK and Grb2:Sos1
  findings: []
- id: Reactome:R-MMU-9817994
  title: Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
  findings: []
- id: Reactome:R-MMU-9818009
  title: Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1
  findings: []
- id: Reactome:R-MMU-983702
  title: Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)
  findings: []
- id: Reactome:R-NUL-420386
  title: Fyn binds NCAM1
  findings: []
- id: Reactome:R-NUL-420388
  title: Dephosphorylation of NCAM1 bound pFyn
  findings: []
- id: Reactome:R-NUL-420398
  title: Autophosphorylation of NCAM1 bound Fyn
  findings: []
- id: Reactome:R-NUL-421136
  title: Recruitment and activation of Cdk5
  findings: []
- id: Reactome:R-NUL-421138
  title: Activation of Fyn
  findings: []
- id: UniProt:P39688
  title: UniProt record for Fyn (P39688)
  findings: []
- id: file:mouse/Fyn/Fyn-deep-research-bioreason.md
  title: Deep research report on Fyn (bioreason)
  findings: []
- id: file:mouse/Fyn/Fyn-deep-research-bioreason-rl.md
  title: Deep research report on Fyn (bioreason-rl)
  findings: []
- id: file:mouse/Fyn/Fyn-deep-research-falcon.md
  title: Deep research report on Fyn (falcon)
  findings: []
core_functions:
- molecular_function:
    id: GO:0004715
    label: non-membrane spanning protein tyrosine kinase activity
  description: Fyn phosphorylates tyrosine residues on signaling proteins as a Src-family
    kinase recruited to membrane-proximal and cytosolic signaling complexes.
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005886
    label: plasma membrane
  - id: GO:0045121
    label: membrane raft
  directly_involved_in:
  - id: GO:0018108
    label: peptidyl-tyrosine phosphorylation
  - id: GO:0035556
    label: intracellular signal transduction
  supported_by:
  - reference_id: UniProt:P39688
    supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
      regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
      cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
      ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR
      LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts.'
  - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
    supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
      context, and evidence synthesis.
- molecular_function:
    id: GO:0004713
    label: protein tyrosine kinase activity
  description: Isoform- and cell-context-specific Fyn signaling contributes directly to T-cell
    receptor and neuronal reelin/synaptic pathways.
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005886
    label: plasma membrane
  directly_involved_in:
  - id: GO:0050852
    label: T cell receptor signaling pathway
  - id: GO:0038026
    label: reelin-mediated signaling pathway
  supported_by:
  - reference_id: UniProt:P39688
    supporting_text: 'FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in
      regulation of cell growth and survival, cell adhesion, integrin-mediated signaling,
      cytoskeletal remodeling, cell motility, immune response and axon guidance. CATALYTIC
      ACTIVITY: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+). SUBCELLULAR
      LOCATION: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts.'
  - reference_id: file:mouse/Fyn/Fyn-deep-research-falcon.md
    supporting_text: Falcon deep research report reviewed for GO term specificity, core-function
      context, and evidence synthesis.
proposed_new_terms: []
suggested_questions: []
suggested_experiments: []

Fyn

Gene Description

Existing Annotations Review

Core Functions

Fyn phosphorylates tyrosine residues on signaling proteins as a Src-family kinase recruited to membrane-proximal and cytosolic signaling complexes.

Isoform- and cell-context-specific Fyn signaling contributes directly to T-cell receptor and neuronal reelin/synaptic pathways.

References

📚 Additional Documentation

Deep Research Bioreason

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Deep Research Bioreason Rl

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Deep Research Falcon

Question

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

Target Gene/Protein Identity (from UniProt):

MANDATORY VERIFICATION STEPS:

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Output

Gene Research for Functional Annotation

⚠️ CRITICAL: Gene/Protein Identification Context

Target Gene/Protein Identity (from UniProt):

MANDATORY VERIFICATION STEPS:

If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

Research Target:

Research report: Functional annotation of mouse Fyn (UniProt P39688, Mus musculus)

0) Identity verification (critical)

1) Key concepts, definitions, and current understanding

1.1 What Fyn is (core definition)

1.2 Domain architecture (how Fyn works as a signaling enzyme)

1.3 Catalytic activity and substrate specificity (what reaction it catalyzes)

1.4 Regulation by phosphorylation (on/off switching)

1.5 Subcellular localization (where Fyn acts)

2) Functional roles and pathways (mechanistic focus)

2.1 Immune signaling: TCR proximal signaling and downstream fate decisions

2.2 Engineered T cells (real-world implementation): CAR-T signaling can be Fyn-driven

2.3 Neurons/synapses: Fyn in excitatory synaptic signaling

2.4 Microglia/neuroinflammation: Fyn→Stat3/NF-κB inflammatory axis

2.5 Oligodendrocytes/myelination: Fyn as a pro-myelinating signaling node

3) Recent developments (prioritizing 2023–2024)

4) Current applications and real-world implementations

4.1 Pharmacologic modulation: SFK inhibitors as Fyn-pathway probes and candidates

4.2 Epilepsy disease modification (preclinical translational example)

4.3 Cancer stratification/biomarkers implicating FYN/SFKs

5) Expert opinions and analysis (from authoritative sources)

6) Data highlights and statistics (recent studies)

7) Visual evidence from a recent primary study

8) Summary table (evidence map)

9) References (URLs and publication dates)

Citations

Bioreason Rl Review

BioReason-Pro RL Review: Fyn (mouse)

Functional Summary Review

Notes on thinking trace

📄 View Raw YAML