Gas6

UniProt ID: Q61592
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Gas6

Existing Annotations Review

GO Term Evidence Action Reason
GO:0043066 negative regulation of apoptotic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005509 calcium ion binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016477 cell migration
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030154 cell differentiation
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031669 cellular response to nutrient levels
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046872 metal ion binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050878 regulation of body fluid levels
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001786 phosphatidylserine binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003104 positive regulation of glomerular filtration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006909 phagocytosis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019064 fusion of virus membrane with host plasma membrane
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019079 viral genome replication
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030674 protein-macromolecule adaptor activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030971 receptor tyrosine kinase binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031100 animal organ regeneration
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032008 positive regulation of TOR signaling
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032689 negative regulation of type II interferon production
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032692 negative regulation of interleukin-1 production
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032715 negative regulation of interleukin-6 production
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032720 negative regulation of tumor necrosis factor production
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032825 positive regulation of natural killer cell differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035457 cellular response to interferon-alpha
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035754 B cell chemotaxis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043277 apoptotic cell clearance
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045892 negative regulation of DNA-templated transcription
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046718 symbiont entry into host cell
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046813 receptor-mediated virion attachment to host cell
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046827 positive regulation of protein export from nucleus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050766 positive regulation of phagocytosis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070168 negative regulation of biomineral tissue development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070588 calcium ion transmembrane transport
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071307 cellular response to vitamin K
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071333 cellular response to glucose stimulus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071466 cellular response to xenobiotic stimulus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072659 protein localization to plasma membrane
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0085029 extracellular matrix assembly
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097028 dendritic cell differentiation
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097241 hematopoietic stem cell migration to bone marrow
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900142 negative regulation of oligodendrocyte apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000270 negative regulation of fibroblast apoptotic process
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000352 negative regulation of endothelial cell apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000510 positive regulation of dendritic cell chemotaxis
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000533 negative regulation of renal albumin absorption
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000669 negative regulation of dendritic cell apoptotic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001934 positive regulation of protein phosphorylation
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001934 positive regulation of protein phosphorylation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
ISO
GO_REF:0000119 		MODIFY
Summary: OVER-ANNOTATION: Gas6 does NOT catalyze phosphorylation itself - it is a secreted "Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER" (UniProt). Gas6 binds these receptor tyrosine kinases, which then autophosphorylate and activate downstream kinase cascades. Gas6 is already correctly annotated to GO:0045860 "positive regulation of protein kinase activity" and GO:0048018 "receptor ligand activity", which accurately describe its role. The phosphorylation process itself is performed by the AXL/TYRO3/MER receptor kinases, not by Gas6.
GO:0032148 activation of protein kinase B activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045860 positive regulation of protein kinase activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001786 phosphatidylserine binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003104 positive regulation of glomerular filtration
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006909 phagocytosis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007166 cell surface receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019064 fusion of virus membrane with host plasma membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019079 viral genome replication
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030674 protein-macromolecule adaptor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030971 receptor tyrosine kinase binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032008 positive regulation of TOR signaling
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032689 negative regulation of type II interferon production
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032692 negative regulation of interleukin-1 production
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032715 negative regulation of interleukin-6 production
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032720 negative regulation of tumor necrosis factor production
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032825 positive regulation of natural killer cell differentiation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035457 cellular response to interferon-alpha
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035754 B cell chemotaxis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043277 apoptotic cell clearance
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045892 negative regulation of DNA-templated transcription
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046718 symbiont entry into host cell
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046813 receptor-mediated virion attachment to host cell
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046827 positive regulation of protein export from nucleus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050766 positive regulation of phagocytosis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070168 negative regulation of biomineral tissue development
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070588 calcium ion transmembrane transport
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071307 cellular response to vitamin K
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071333 cellular response to glucose stimulus
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071466 cellular response to xenobiotic stimulus
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071466 cellular response to xenobiotic stimulus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072659 protein localization to plasma membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097241 hematopoietic stem cell migration to bone marrow
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900142 negative regulation of oligodendrocyte apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000270 negative regulation of fibroblast apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000352 negative regulation of endothelial cell apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000510 positive regulation of dendritic cell chemotaxis
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000669 negative regulation of dendritic cell apoptotic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048018 receptor ligand activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030674 protein-macromolecule adaptor activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
HDA
PMID:24006456
Extracellular matrix secretion by cardiac fibroblasts: role ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24006456
Epub 2013 Sep 4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
GO:0046827 positive regulation of protein export from nucleus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045860 positive regulation of protein kinase activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032715 negative regulation of interleukin-6 production
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019064 fusion of virus membrane with host plasma membrane
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046813 receptor-mediated virion attachment to host cell
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001786 phosphatidylserine binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006909 phagocytosis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019079 viral genome replication
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032689 negative regulation of type II interferon production
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032692 negative regulation of interleukin-1 production
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032720 negative regulation of tumor necrosis factor production
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032825 positive regulation of natural killer cell differentiation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035457 cellular response to interferon-alpha
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035754 B cell chemotaxis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045892 negative regulation of DNA-templated transcription
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046718 symbiont entry into host cell
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050766 positive regulation of phagocytosis
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070168 negative regulation of biomineral tissue development
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097241 hematopoietic stem cell migration to bone marrow
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000669 negative regulation of dendritic cell apoptotic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001934 positive regulation of protein phosphorylation
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003104 positive regulation of glomerular filtration
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006468 protein phosphorylation
ISS
GO_REF:0000024 		MODIFY
Summary: OVER-ANNOTATION: Gas6 does NOT catalyze phosphorylation itself - it is a secreted ligand for receptor tyrosine kinases AXL, TYRO3, and MER. The receptor kinases perform the phosphorylation upon Gas6 binding, not Gas6 itself. Gas6 is already correctly annotated to GO:0045860 "positive regulation of protein kinase activity" which accurately describes its role as a kinase activator.
GO:0032008 positive regulation of TOR signaling
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032148 activation of protein kinase B activity
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071307 cellular response to vitamin K
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071333 cellular response to glucose stimulus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071466 cellular response to xenobiotic stimulus
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072659 protein localization to plasma membrane
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0085029 extracellular matrix assembly
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000270 negative regulation of fibroblast apoptotic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000352 negative regulation of endothelial cell apoptotic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000533 negative regulation of renal albumin absorption
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043066 negative regulation of apoptotic process
IDA
PMID:16723520
Gas6/Axl signaling activates the phosphatidylinositol 3-kina... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16723520
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.
GO:0001764 neuron migration
IGI
PMID:18787040
Axl and Tyro3 modulate female reproduction by influencing go... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18787040
Sep 11. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration.
GO:0005615 extracellular space
IDA
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
GO:0031589 cell-substrate adhesion
IMP
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
GO:0043066 negative regulation of apoptotic process
IMP
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
GO:0043277 apoptotic cell clearance
IDA
PMID:18159085
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regul... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18159085
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IMP
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
GO:0071363 cellular response to growth factor stimulus
IMP
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
GO:0007596 blood coagulation
IMP
PMID:15184064
Vitamin K-dependent Gas6 activates ERK kinase and stimulates... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15184064
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
GO:0043066 negative regulation of apoptotic process
IMP
PMID:15184064
Vitamin K-dependent Gas6 activates ERK kinase and stimulates... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15184064
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
GO:0048018 receptor ligand activity
ISO
GO_REF:0000008 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation
ISO
GO_REF:0000008 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IGI
PMID:15650770
Role of Gas6 receptors in platelet signaling during thrombus... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15650770
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
GO:0070374 positive regulation of ERK1 and ERK2 cascade
ISO
GO_REF:0000008 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007167 enzyme-linked receptor protein signaling pathway
IGI
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.
GO:0043066 negative regulation of apoptotic process
IDA
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.
GO:0043066 negative regulation of apoptotic process
IGI
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.
GO:0048018 receptor ligand activity
IDA
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.
GO:0005615 extracellular space
ISO
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
GO:0009267 cellular response to starvation
IDA
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
GO:0071363 cellular response to growth factor stimulus
IDA
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000008
Gene Ontology annotation by the MGI curatorial staff, curated orthology
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:15184064
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
PMID:15650770
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
PMID:16723520
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.
PMID:18159085
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells.
PMID:18188450
Role of Gas6 in erythropoiesis and anemia in mice.
PMID:18787040
Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration.
PMID:24006456
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
PMID:8336730
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
PMID:9395235
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.

📄 View Raw YAML

 
id: Q61592
gene_symbol: Gas6
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Gas6'
existing_annotations:
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016477
      label: cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031669
      label: cellular response to nutrient levels
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050878
      label: regulation of body fluid levels
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001786
      label: phosphatidylserine binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001961
      label: positive regulation of cytokine-mediated signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006909
      label: phagocytosis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010804
      label: negative regulation of tumor necrosis factor-mediated signaling 
        pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019064
      label: fusion of virus membrane with host plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019079
      label: viral genome replication
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030971
      label: receptor tyrosine kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031100
      label: animal organ regeneration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032008
      label: positive regulation of TOR signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032689
      label: negative regulation of type II interferon production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032692
      label: negative regulation of interleukin-1 production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032825
      label: positive regulation of natural killer cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035457
      label: cellular response to interferon-alpha
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035754
      label: B cell chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043027
      label: cysteine-type endopeptidase inhibitor activity involved in 
        apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046718
      label: symbiont entry into host cell
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046813
      label: receptor-mediated virion attachment to host cell
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046827
      label: positive regulation of protein export from nucleus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050766
      label: positive regulation of phagocytosis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070168
      label: negative regulation of biomineral tissue development
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071307
      label: cellular response to vitamin K
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072659
      label: protein localization to plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0085029
      label: extracellular matrix assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097028
      label: dendritic cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097241
      label: hematopoietic stem cell migration to bone marrow
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900142
      label: negative regulation of oligodendrocyte apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000270
      label: negative regulation of fibroblast apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000510
      label: positive regulation of dendritic cell chemotaxis
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000533
      label: negative regulation of renal albumin absorption
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000669
      label: negative regulation of dendritic cell apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: >-
        OVER-ANNOTATION: Gas6 does NOT catalyze phosphorylation itself - it is a secreted
        "Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER" (UniProt).
        Gas6
        binds these receptor tyrosine kinases, which then autophosphorylate and activate
        downstream kinase cascades. Gas6 is already correctly annotated to GO:0045860
        "positive regulation of protein kinase activity" and GO:0048018 "receptor
        ligand
        activity", which accurately describe its role. The phosphorylation process
        itself
        is performed by the AXL/TYRO3/MER receptor kinases, not by Gas6.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
  - term:
      id: GO:0032148
      label: activation of protein kinase B activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001786
      label: phosphatidylserine binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001961
      label: positive regulation of cytokine-mediated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006909
      label: phagocytosis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010804
      label: negative regulation of tumor necrosis factor-mediated signaling 
        pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019064
      label: fusion of virus membrane with host plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019079
      label: viral genome replication
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030971
      label: receptor tyrosine kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032008
      label: positive regulation of TOR signaling
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032689
      label: negative regulation of type II interferon production
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032692
      label: negative regulation of interleukin-1 production
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032825
      label: positive regulation of natural killer cell differentiation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035457
      label: cellular response to interferon-alpha
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035754
      label: B cell chemotaxis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043027
      label: cysteine-type endopeptidase inhibitor activity involved in 
        apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046718
      label: symbiont entry into host cell
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046813
      label: receptor-mediated virion attachment to host cell
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046827
      label: positive regulation of protein export from nucleus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050766
      label: positive regulation of phagocytosis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070168
      label: negative regulation of biomineral tissue development
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071307
      label: cellular response to vitamin K
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072659
      label: protein localization to plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097241
      label: hematopoietic stem cell migration to bone marrow
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1900142
      label: negative regulation of oligodendrocyte apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000270
      label: negative regulation of fibroblast apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000510
      label: positive regulation of dendritic cell chemotaxis
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000669
      label: negative regulation of dendritic cell apoptotic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: HDA
    original_reference_id: PMID:24006456
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24006456
          supporting_text: 'Epub 2013 Sep 4. Extracellular matrix secretion by cardiac
            fibroblasts: role of microRNA-29b and microRNA-30c.'
  - term:
      id: GO:0046827
      label: positive regulation of protein export from nucleus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019064
      label: fusion of virus membrane with host plasma membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046813
      label: receptor-mediated virion attachment to host cell
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001786
      label: phosphatidylserine binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001961
      label: positive regulation of cytokine-mediated signaling pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006909
      label: phagocytosis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0010804
      label: negative regulation of tumor necrosis factor-mediated signaling 
        pathway
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019079
      label: viral genome replication
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032689
      label: negative regulation of type II interferon production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032692
      label: negative regulation of interleukin-1 production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032825
      label: positive regulation of natural killer cell differentiation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035457
      label: cellular response to interferon-alpha
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0035754
      label: B cell chemotaxis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043027
      label: cysteine-type endopeptidase inhibitor activity involved in 
        apoptotic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046718
      label: symbiont entry into host cell
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050766
      label: positive regulation of phagocytosis
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070168
      label: negative regulation of biomineral tissue development
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0097241
      label: hematopoietic stem cell migration to bone marrow
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000669
      label: negative regulation of dendritic cell apoptotic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: >-
        OVER-ANNOTATION: Gas6 does NOT catalyze phosphorylation itself - it is a secreted
        ligand for receptor tyrosine kinases AXL, TYRO3, and MER. The receptor kinases
        perform the phosphorylation upon Gas6 binding, not Gas6 itself. Gas6 is already
        correctly annotated to GO:0045860 "positive regulation of protein kinase activity"
        which accurately describes its role as a kinase activator.
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
  - term:
      id: GO:0032008
      label: positive regulation of TOR signaling
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032148
      label: activation of protein kinase B activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071307
      label: cellular response to vitamin K
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0072659
      label: protein localization to plasma membrane
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0085029
      label: extracellular matrix assembly
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000270
      label: negative regulation of fibroblast apoptotic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000533
      label: negative regulation of renal albumin absorption
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:16723520
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16723520
          supporting_text: Gas6/Axl signaling activates the phosphatidylinositol
            3-kinase/Akt1 survival pathway to protect oligodendrocytes from 
            tumor necrosis factor alpha-induced apoptosis.
  - term:
      id: GO:0001764
      label: neuron migration
    evidence_type: IGI
    original_reference_id: PMID:18787040
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18787040
          supporting_text: Sep 11. Axl and Tyro3 modulate female reproduction by
            influencing gonadotropin-releasing hormone neuron survival and 
            migration.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:18188450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18188450
          supporting_text: Role of Gas6 in erythropoiesis and anemia in mice.
  - term:
      id: GO:0031589
      label: cell-substrate adhesion
    evidence_type: IMP
    original_reference_id: PMID:18188450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18188450
          supporting_text: Role of Gas6 in erythropoiesis and anemia in mice.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:18188450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18188450
          supporting_text: Role of Gas6 in erythropoiesis and anemia in mice.
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: IDA
    original_reference_id: PMID:18159085
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18159085
          supporting_text: Gas6 and the Tyro 3 receptor tyrosine kinase 
            subfamily regulate the phagocytic function of Sertoli cells.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IMP
    original_reference_id: PMID:18188450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18188450
          supporting_text: Role of Gas6 in erythropoiesis and anemia in mice.
  - term:
      id: GO:0071363
      label: cellular response to growth factor stimulus
    evidence_type: IMP
    original_reference_id: PMID:18188450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18188450
          supporting_text: Role of Gas6 in erythropoiesis and anemia in mice.
  - term:
      id: GO:0007596
      label: blood coagulation
    evidence_type: IMP
    original_reference_id: PMID:15184064
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15184064
          supporting_text: Vitamin K-dependent Gas6 activates ERK kinase and 
            stimulates growth of cardiac fibroblasts.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IMP
    original_reference_id: PMID:15184064
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15184064
          supporting_text: Vitamin K-dependent Gas6 activates ERK kinase and 
            stimulates growth of cardiac fibroblasts.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IGI
    original_reference_id: PMID:15650770
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15650770
          supporting_text: Role of Gas6 receptors in platelet signaling during 
            thrombus stabilization and implications for antithrombotic therapy.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000008
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007167
      label: enzyme-linked receptor protein signaling pathway
    evidence_type: IGI
    original_reference_id: PMID:9395235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9395235
          supporting_text: Signaling through the ARK tyrosine kinase receptor 
            protects from apoptosis in the absence of growth stimulation.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:9395235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9395235
          supporting_text: Signaling through the ARK tyrosine kinase receptor 
            protects from apoptosis in the absence of growth stimulation.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IGI
    original_reference_id: PMID:9395235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9395235
          supporting_text: Signaling through the ARK tyrosine kinase receptor 
            protects from apoptosis in the absence of growth stimulation.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:9395235
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9395235
          supporting_text: Signaling through the ARK tyrosine kinase receptor 
            protects from apoptosis in the absence of growth stimulation.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: PMID:8336730
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8336730
          supporting_text: The protein encoded by a growth arrest-specific gene 
            (gas6) is a new member of the vitamin K-dependent proteins related 
            to protein S, a negative coregulator in the blood coagulation 
            cascade.
  - term:
      id: GO:0009267
      label: cellular response to starvation
    evidence_type: IDA
    original_reference_id: PMID:8336730
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8336730
          supporting_text: The protein encoded by a growth arrest-specific gene 
            (gas6) is a new member of the vitamin K-dependent proteins related 
            to protein S, a negative coregulator in the blood coagulation 
            cascade.
  - term:
      id: GO:0071363
      label: cellular response to growth factor stimulus
    evidence_type: IDA
    original_reference_id: PMID:8336730
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8336730
          supporting_text: The protein encoded by a growth arrest-specific gene 
            (gas6) is a new member of the vitamin K-dependent proteins related 
            to protein S, a negative coregulator in the blood coagulation 
            cascade.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000008
    title: Gene Ontology annotation by the MGI curatorial staff, curated 
      orthology
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:15184064
    title: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth 
      of cardiac fibroblasts.
    findings: []
  - id: PMID:15650770
    title: Role of Gas6 receptors in platelet signaling during thrombus 
      stabilization and implications for antithrombotic therapy.
    findings: []
  - id: PMID:16723520
    title: Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 
      survival pathway to protect oligodendrocytes from tumor necrosis factor 
      alpha-induced apoptosis.
    findings: []
  - id: PMID:18159085
    title: Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the 
      phagocytic function of Sertoli cells.
    findings: []
  - id: PMID:18188450
    title: Role of Gas6 in erythropoiesis and anemia in mice.
    findings: []
  - id: PMID:18787040
    title: Axl and Tyro3 modulate female reproduction by influencing 
      gonadotropin-releasing hormone neuron survival and migration.
    findings: []
  - id: PMID:24006456
    title: 'Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b
      and microRNA-30c.'
    findings: []
  - id: PMID:8336730
    title: The protein encoded by a growth arrest-specific gene (gas6) is a new 
      member of the vitamin K-dependent proteins related to protein S, a 
      negative coregulator in the blood coagulation cascade.
    findings: []
  - id: PMID:9395235
    title: Signaling through the ARK tyrosine kinase receptor protects from 
      apoptosis in the absence of growth stimulation.
    findings: []