Ghr

UniProt ID: P16882
Organism: Mus musculus
Review Status: INITIALIZED
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Gene Description

TODO: Add description for Ghr

Existing Annotations Review

GO Term Evidence Action Reason
GO:0009897 external side of plasma membrane
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019221 cytokine-mediated signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004903 growth hormone receptor activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060396 growth hormone receptor signaling pathway
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019955 cytokine binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017046 peptide hormone binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070195 growth hormone receptor complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004896 cytokine receptor activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004903 growth hormone receptor activity
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006897 endocytosis
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060396 growth hormone receptor signaling pathway
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004903 growth hormone receptor activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008289 lipid binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009986 cell surface
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017046 peptide hormone binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019838 growth factor binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031623 receptor internalization
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032355 response to estradiol
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032870 cellular response to hormone stimulus
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0040018 positive regulation of multicellular organism growth
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042445 hormone metabolic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042803 protein homodimerization activity
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043235 receptor complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046898 response to cycloheximide
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048009 insulin-like growth factor receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060396 growth hormone receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070195 growth hormone receptor complex
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042976 activation of Janus kinase activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004903 growth hormone receptor activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005615 extracellular space
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007259 cell surface receptor signaling pathway via JAK-STAT
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0009755 hormone-mediated signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019901 protein kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019903 protein phosphatase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030296 protein tyrosine kinase activator activity
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032107 regulation of response to nutrient levels
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042169 SH2 domain binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043025 neuronal cell body
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043410 positive regulation of MAPK cascade
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060396 growth hormone receptor signaling pathway
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060400 negative regulation of growth hormone receptor signaling pathway
ISO
GO_REF:0000119 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990782 protein tyrosine kinase binding
ISO
GO_REF:0000096 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
IDA
PMID:8702683
Growth hormone promotes the association of transcription fac... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8702683
Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor.
GO:0016020 membrane
IDA
PMID:11834450
Structurally distinct membrane-associated and soluble forms ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:11834450
Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse.
GO:0019530 taurine metabolic process
IMP
PMID:18648510
Altered metabolism of growth hormone receptor mutant mice: a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18648510
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study.
GO:0040014 regulation of multicellular organism growth
IMP
PMID:18648510
Altered metabolism of growth hormone receptor mutant mice: a... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:18648510
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study.
GO:0005615 extracellular space
HDA
PMID:24006456
Extracellular matrix secretion by cardiac fibroblasts: role ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:24006456
Epub 2013 Sep 4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1168790 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1168910 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1168923 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1168927 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169194 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169229 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169240 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169250 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169142 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
TAS
Reactome:R-MMU-1169206 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-MMU-1168790 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:8702683
Growth hormone promotes the association of transcription fac... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8702683
Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor.
GO:0004903 growth hormone receptor activity
IDA
PMID:6303755
Hepatic binding of human and bovine growth hormones and ovin... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:6303755
Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse.
GO:0017046 peptide hormone binding
IPI
PMID:10556780
Up-regulation of GH-binding protein by mouse GH in transgeni... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10556780
Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone.
GO:0005634 nucleus
IDA
PMID:9144201
Functional growth hormone (GH) receptors and GH are expresse... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9144201
Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Pantaleon M(1), Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL.
GO:0005886 plasma membrane
IDA
PMID:9144201
Functional growth hormone (GH) receptors and GH are expresse... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:9144201
Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Pantaleon M(1), Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000096
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000119
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
PMID:10556780
Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone.
PMID:11834450
Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse.
PMID:18648510
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study.
PMID:24006456
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
PMID:6303755
Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse.
PMID:8702683
Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor.
PMID:9144201
Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?
Reactome:R-MMU-1168790
ADAM17 cleavage of Ghr
Reactome:R-MMU-1168910
Stat5 association with Ghr
Reactome:R-MMU-1168923
Stat5 tyrosine phosphorylation
Reactome:R-MMU-1168927
Growth hormone receptor binds Lyn
Reactome:R-MMU-1169142
Jak2 binds Stat1/Stat3
Reactome:R-MMU-1169194
Socs binding to JAK2
Reactome:R-MMU-1169206
Jak2 phosphorylates Stat1/Stat3
Reactome:R-MMU-1169229
Ptp1b dephosphorylates Jak2
Reactome:R-MMU-1169240
Shp1 (Ptpn6) dephosphorylates Jak2
Reactome:R-MMU-1169250
Shp1 binds Jak2 in the receptor complex

📄 View Raw YAML

 
id: P16882
gene_symbol: Ghr
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Ghr'
existing_annotations:
  - term:
      id: GO:0009897
      label: external side of plasma membrane
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019221
      label: cytokine-mediated signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046427
      label: positive regulation of receptor signaling pathway via JAK-STAT
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004903
      label: growth hormone receptor activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060396
      label: growth hormone receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008284
      label: positive regulation of cell population proliferation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019955
      label: cytokine binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017046
      label: peptide hormone binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070195
      label: growth hormone receptor complex
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004896
      label: cytokine receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004903
      label: growth hormone receptor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0006897
      label: endocytosis
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060396
      label: growth hormone receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004903
      label: growth hormone receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008289
      label: lipid binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0017046
      label: peptide hormone binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019838
      label: growth factor binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031623
      label: receptor internalization
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032355
      label: response to estradiol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032870
      label: cellular response to hormone stimulus
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0040018
      label: positive regulation of multicellular organism growth
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042445
      label: hormone metabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042802
      label: identical protein binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042803
      label: protein homodimerization activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043235
      label: receptor complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046898
      label: response to cycloheximide
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048009
      label: insulin-like growth factor receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060396
      label: growth hormone receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0070195
      label: growth hormone receptor complex
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0036464
      label: cytoplasmic ribonucleoprotein granule
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042976
      label: activation of Janus kinase activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004903
      label: growth hormone receptor activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007259
      label: cell surface receptor signaling pathway via JAK-STAT
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0009755
      label: hormone-mediated signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019901
      label: protein kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0019903
      label: protein phosphatase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030296
      label: protein tyrosine kinase activator activity
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032107
      label: regulation of response to nutrient levels
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0042169
      label: SH2 domain binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043025
      label: neuronal cell body
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043161
      label: proteasome-mediated ubiquitin-dependent protein catabolic process
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043410
      label: positive regulation of MAPK cascade
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046427
      label: positive regulation of receptor signaling pathway via JAK-STAT
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060396
      label: growth hormone receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060397
      label: growth hormone receptor signaling pathway via JAK-STAT
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060400
      label: negative regulation of growth hormone receptor signaling pathway
    evidence_type: ISO
    original_reference_id: GO_REF:0000119
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1990782
      label: protein tyrosine kinase binding
    evidence_type: ISO
    original_reference_id: GO_REF:0000096
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0060397
      label: growth hormone receptor signaling pathway via JAK-STAT
    evidence_type: IDA
    original_reference_id: PMID:8702683
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8702683
          supporting_text: Growth hormone promotes the association of 
            transcription factor STAT5 with the growth hormone receptor.
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IDA
    original_reference_id: PMID:11834450
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:11834450
          supporting_text: Structurally distinct membrane-associated and soluble
            forms of GH-binding protein in the mouse.
  - term:
      id: GO:0019530
      label: taurine metabolic process
    evidence_type: IMP
    original_reference_id: PMID:18648510
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18648510
          supporting_text: 'Altered metabolism of growth hormone receptor mutant mice:
            a combined NMR metabonomics and microarray study.'
  - term:
      id: GO:0040014
      label: regulation of multicellular organism growth
    evidence_type: IMP
    original_reference_id: PMID:18648510
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18648510
          supporting_text: 'Altered metabolism of growth hormone receptor mutant mice:
            a combined NMR metabonomics and microarray study.'
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: HDA
    original_reference_id: PMID:24006456
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:24006456
          supporting_text: 'Epub 2013 Sep 4. Extracellular matrix secretion by cardiac
            fibroblasts: role of microRNA-29b and microRNA-30c.'
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1168790
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1168910
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1168923
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1168927
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169194
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169229
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169240
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169250
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169142
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1169206
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-MMU-1168790
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:8702683
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8702683
          supporting_text: Growth hormone promotes the association of 
            transcription factor STAT5 with the growth hormone receptor.
  - term:
      id: GO:0004903
      label: growth hormone receptor activity
    evidence_type: IDA
    original_reference_id: PMID:6303755
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:6303755
          supporting_text: Hepatic binding of human and bovine growth hormones 
            and ovine prolactin in the dwarf "little" mouse.
  - term:
      id: GO:0017046
      label: peptide hormone binding
    evidence_type: IPI
    original_reference_id: PMID:10556780
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10556780
          supporting_text: Up-regulation of GH-binding protein by mouse GH in 
            transgenic mice overexpressing GH-releasing hormone.
  - term:
      id: GO:0005634
      label: nucleus
    evidence_type: IDA
    original_reference_id: PMID:9144201
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9144201
          supporting_text: 'Functional growth hormone (GH) receptors and GH are expressed
            by preimplantation mouse embryos: a role for GH in early embryogenesis?
            Pantaleon M(1), Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL.'
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:9144201
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:9144201
          supporting_text: 'Functional growth hormone (GH) receptors and GH are expressed
            by preimplantation mouse embryos: a role for GH in early embryogenesis?
            Pantaleon M(1), Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL.'
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000096
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-rat orthologs
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000119
    title: Automated transfer of experimentally-verified manual GO annotation 
      data to mouse-human orthologs
    findings: []
  - id: PMID:10556780
    title: Up-regulation of GH-binding protein by mouse GH in transgenic mice 
      overexpressing GH-releasing hormone.
    findings: []
  - id: PMID:11834450
    title: Structurally distinct membrane-associated and soluble forms of 
      GH-binding protein in the mouse.
    findings: []
  - id: PMID:18648510
    title: "Altered metabolism of growth hormone receptor mutant mice: a combined
      NMR metabonomics and microarray study."
    findings: []
  - id: PMID:24006456
    title: 'Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b
      and microRNA-30c.'
    findings: []
  - id: PMID:6303755
    title: Hepatic binding of human and bovine growth hormones and ovine 
      prolactin in the dwarf "little" mouse.
    findings: []
  - id: PMID:8702683
    title: Growth hormone promotes the association of transcription factor STAT5
      with the growth hormone receptor.
    findings: []
  - id: PMID:9144201
    title: 'Functional growth hormone (GH) receptors and GH are expressed by preimplantation
      mouse embryos: a role for GH in early embryogenesis?'
    findings: []
  - id: Reactome:R-MMU-1168790
    title: ADAM17 cleavage of Ghr
    findings: []
  - id: Reactome:R-MMU-1168910
    title: Stat5 association with Ghr
    findings: []
  - id: Reactome:R-MMU-1168923
    title: Stat5 tyrosine phosphorylation
    findings: []
  - id: Reactome:R-MMU-1168927
    title: Growth hormone receptor binds Lyn
    findings: []
  - id: Reactome:R-MMU-1169142
    title: Jak2 binds Stat1/Stat3
    findings: []
  - id: Reactome:R-MMU-1169194
    title: Socs binding to JAK2
    findings: []
  - id: Reactome:R-MMU-1169206
    title: Jak2 phosphorylates Stat1/Stat3
    findings: []
  - id: Reactome:R-MMU-1169229
    title: Ptp1b dephosphorylates Jak2
    findings: []
  - id: Reactome:R-MMU-1169240
    title: Shp1 (Ptpn6) dephosphorylates Jak2
    findings: []
  - id: Reactome:R-MMU-1169250
    title: Shp1 binds Jak2 in the receptor complex
    findings: []