Hsp90aa1

Summary: protein folding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: ATP hydrolysis activity is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein-containing complex is true but too generic for Hsp90aa1 chaperone complexes.

Reason: Use GO:0101031 protein folding chaperone complex for Hsp90 co-chaperone/client assemblies.

Proposed replacements: protein folding chaperone complex

Summary: plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ATP binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: nucleus is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein stabilization is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cellular response to heat is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Unfolded protein binding is not the best description of Hsp90aa1. Hsp90 is an ATP-dependent foldase for selected clients rather than a generic unfolded-protein holdase.

Reason: GO:0051082 is now formally obsolete, its upstream name being "obsolete unfolded protein binding". This repository records that in three tracked files, two of them machine-fetched upstream data: gocams/68b0f0d000005090/68b0f0d000005090-src.yaml:2436 and gocams/69729a3800002828/69729a3800002828-src.yaml:2717 both carry "label: obsolete unfolded protein binding", and projects/UNFOLDED_PROTEIN_BINDING.md:14 records it as checked live against QuickGO and OLS on 2026-07-25. What the local ontology snapshots carry is the pre-obsoletion label "unfolded protein binding" - cache/go/terms.csv, cache/ontologies/go.tsv (which additionally records is_obsolete False), and this gene's GOA rows - so a term-cache lookup alone will not show the obsoletion, which is why it is cited from the gocam caches instead. That project reclassifies such rows to a mechanism-specific MF term rather than leaving a generic binding term in place. Hsp90 is an ATP-dependent foldase, so GO:0140662 ATP-dependent protein folding chaperone is the term the project assigns to this class - the same replacement it records for the budding-yeast HSP90 paralogs HSP82 and HSC82, which are themselves the IBD seeds behind this very row.

Proposed replacements: ATP-dependent protein folding chaperone

Summary: neuronal cell body is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: myelin sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: perinuclear region of cytoplasm is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ATP binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: nucleus is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: mitochondrion is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein folding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: ATP hydrolysis activity is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: regulation of protein localization is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: melanosome is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein folding chaperone is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: dendritic growth cone is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: axonal growth cone is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Unfolded protein binding is not the best description of Hsp90aa1. Hsp90 is an ATP-dependent foldase for selected clients rather than a generic unfolded-protein holdase.

Reason: Replace with GO:0140662 ATP-dependent protein folding chaperone, which captures the ATP-driven Hsp90 mechanism.

Proposed replacements: ATP-dependent protein folding chaperone

Summary: ATP-dependent protein folding chaperone is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: neuron migration is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to dietary excess is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: UTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: CTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: activation of innate immune response is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of defense response to virus by host is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: skeletal muscle contraction is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: mRNA binding is too broad or indirect to be informative for Hsp90aa1 curation.

Reason: The term does not distinguish Hsp90aa1 ATP-dependent chaperone activity from generic binding, complex membership, RNA association, or co-fractionation.

Summary: GTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: response to xenobiotic stimulus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to salt stress is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cell surface is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of lamellipodium assembly is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cardiac muscle cell apoptotic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: negative regulation of striated muscle cell apoptotic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: basolateral plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: apical plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sulfonylurea receptor binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein phosphatase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein import into mitochondrial matrix is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: nitric-oxide synthase regulator activity is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: TPR domain binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: extracellular matrix is too broad or indirect to be informative for Hsp90aa1 curation.

Reason: The term does not distinguish Hsp90aa1 ATP-dependent chaperone activity from generic binding, complex membership, RNA association, or co-fractionation.

Summary: regulation of protein ubiquitination is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: brush border membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ubiquitin protein ligase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of protein polymerization is a peripheral or orthology-transferred Hsp90-associated annotation rather than a core Hsp90aa1 function.

Reason: The annotation is not impossible for Hsp90 biology, but the evidence is indirect or context-specific compared with the core ATP-dependent chaperone function.

Summary: response to follicle-stimulating hormone is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: dATP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: positive regulation of interferon-beta production is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Protein-containing complex is true but too generic for Hsp90aa1 chaperone complexes.

Reason: Use GO:0101031 protein folding chaperone complex for Hsp90 co-chaperone/client assemblies.

Proposed replacements: protein folding chaperone complex

Summary: cellular response to heat is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: response to isolation stress is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to platelet-derived growth factor stimulus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sperm flagellum is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: IEA orthology projection (GO_REF:0000107, Ensembl Compara) of a drug-response term onto a general cytosolic/nuclear molecular chaperone. There is no Hsp90aa1-specific experimental evidence that "response to cocaine" reflects a distinct biological role of this gene; any involvement would be the generic chaperoning of a client protein, not a cocaine-response function.

Reason: Over-propagation by ortholog transfer onto a hub chaperone. HSP90 buffers thousands of clients, so projecting a single-species drug-response phenotype onto it adds no functional information and is not supported by direct Hsp90aa1 evidence. This mirrors the treatment of the identical IEA cocaine annotation on SMAD3 (also GO_REF:0000107), which is marked as over-annotated for the same reason.

Summary: positive regulation of protein import into nucleus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: identical protein binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein homodimerization activity is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: histone deacetylase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: regulation of apoptotic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: neuronal cell body is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: myelin sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to estrogen is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: transmembrane transporter binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of protein catabolic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of cell size is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: tau protein binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: perinuclear region of cytoplasm is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein stabilization is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: GTPase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Rho GDP-dissociation inhibitor binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: chaperone-mediated protein complex assembly is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein maturation is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: positive regulation of cardiac muscle contraction is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to caloric restriction is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: DNA polymerase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to hydrogen peroxide is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to lipopolysaccharide is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to mechanical stimulus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to hypoxia is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: scaffold protein binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sperm mitochondrial sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sperm plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: disordered domain specific binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to virus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: regulation of postsynaptic membrane neurotransmitter receptor levels is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein folding chaperone complex is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: neurofibrillary tangle assembly is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: telomerase holoenzyme complex assembly is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein tyrosine kinase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: neuron migration is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: UTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: CTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: mRNA binding is too broad or indirect to be informative for Hsp90aa1 curation.

Reason: The term does not distinguish Hsp90aa1 ATP-dependent chaperone activity from generic binding, complex membership, RNA association, or co-fractionation.

Summary: ATP binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: ATP binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: GTP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: nucleus is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: mitochondrion is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cell surface is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of lamellipodium assembly is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: negative regulation of striated muscle cell apoptotic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: basolateral plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: apical plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ATP hydrolysis activity is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: sulfonylurea receptor binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein phosphatase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: nitric-oxide synthase regulator activity is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: TPR domain binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: extracellular matrix is too broad or indirect to be informative for Hsp90aa1 curation.

Reason: The term does not distinguish Hsp90aa1 ATP-dependent chaperone activity from generic binding, complex membership, RNA association, or co-fractionation.

Summary: brush border membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ubiquitin protein ligase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: dATP binding is not supported as a biologically meaningful Hsp90aa1 nucleotide-binding function.

Reason: Hsp90aa1 is an ATP-binding ATPase; automated transfer to other nucleotide-binding terms overstates the evidence.

Summary: Protein-containing complex is true but too generic for Hsp90aa1 chaperone complexes.

Reason: Use GO:0101031 protein folding chaperone complex for Hsp90 co-chaperone/client assemblies.

Proposed replacements: protein folding chaperone complex

Summary: Protein-containing complex is true but too generic for Hsp90aa1 chaperone complexes.

Reason: Use GO:0101031 protein folding chaperone complex for Hsp90 co-chaperone/client assemblies.

Proposed replacements: protein folding chaperone complex

Summary: sperm flagellum is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of protein import into nucleus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: identical protein binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein homodimerization activity is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: histone deacetylase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: neuronal cell body is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: myelin sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: transmembrane transporter binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of cell size is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: tau protein binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: tau protein binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: perinuclear region of cytoplasm is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: GTPase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Rho GDP-dissociation inhibitor binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: DNA polymerase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: scaffold protein binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sperm mitochondrial sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: sperm plasma membrane is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: disordered domain specific binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: regulation of postsynaptic membrane neurotransmitter receptor levels is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein folding chaperone complex is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: enzyme-substrate adaptor activity is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: protein tyrosine kinase binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: nucleoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein folding chaperone is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Cannot be adjudicated here: PMID:19010779 is cached abstract-only. Prior observation, not a verdict: AP-3 adaptor complex binding is not supported by the cached local evidence for PMID:19010779.

Reason: PMID:19010779 is cached abstract-only, so the curator's experimental evidence cannot be inspected here; per CLAUDE.md an experimental annotation is not overruled on that basis. Recorded observation, not a verdict: The cached PMID:19010779 text does not provide positive Hsp90aa1-specific evidence for AP-3 adaptor complex binding; generic cytosol/nucleus support is insufficient to retain this molecular interaction.

Summary: activation of innate immune response is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of defense response to virus by host is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: mitochondrion is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: positive regulation of interferon-beta production is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: regulation of apoptotic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cellular response to virus is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: identical protein binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein folding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein-containing complex is true but too generic for Hsp90aa1 chaperone complexes.

Reason: Use GO:0101031 protein folding chaperone complex for Hsp90 co-chaperone/client assemblies.

Proposed replacements: protein folding chaperone complex

Summary: cellular response to heat is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: protein folding chaperone is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: regulation of protein localization is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: neuronal cell body is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: dendritic growth cone is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: axonal growth cone is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: perinuclear region of cytoplasm is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: ATP binding is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: response to antibiotic is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: nucleus is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: response to heat is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to cold is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: myelin sheath is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: cytoplasm is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: TPR domain binding is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: response to unfolded protein is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Unfolded protein binding is not the best description of Hsp90aa1. Hsp90 is an ATP-dependent foldase for selected clients rather than a generic unfolded-protein holdase.

Reason: Replace with GO:0140662 ATP-dependent protein folding chaperone, which captures the ATP-driven Hsp90 mechanism.

Proposed replacements: ATP-dependent protein folding chaperone

Summary: Protein binding is an uninformative physical-interaction annotation for Hsp90aa1.

Reason: Hsp90 has many client and co-chaperone interactions; the useful functional call is ATP-dependent protein folding chaperone or a specific partner-binding term where justified.

Summary: cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.

Reason: This term captures a central molecular activity, process, complex, or main localization of Hsp90aa1.

Summary: nitric oxide biosynthetic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: nitric-oxide synthase regulator activity is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: PMID:12855682 supports Hsp90-dependent iNOS/NO modulation, while UniProt and the Falcon synthesis support the general ATP-dependent chaperone cycle; the cited PMID does not support protein refolding specifically.

Reason: PMID:12855682 supports Hsp90-dependent modulation of iNOS/NO production, not protein refolding specifically. Replace with the core ATP-dependent protein-folding chaperone activity based on UniProt/Falcon support for the HSP90 ATPase-coupled chaperone cycle.

Proposed replacements: ATP-dependent protein folding chaperone

Summary: positive regulation of nitric oxide biosynthetic process is supported or plausible for a specific Hsp90aa1 client, localization, stress, or tissue context, but it is not the conserved core chaperone function.

Reason: Retain this annotation as context-specific while keeping the core review focused on ATP-dependent chaperone activity and cytosolic/nuclear chaperone complexes.

Summary: Positive regulation of cytotoxic T cell differentiation is not supported by PMID:12855682, which addresses iNOS-mediated nitric oxide production and cytotoxicity.

Reason: PMID:12855682 supports iNOS-mediated nitric oxide production and cytotoxicity, not cytotoxic T-cell differentiation. Generic Hsp90 location/function evidence does not support retaining this BP annotation.