Jak1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0007259 cell surface receptor signaling pathway via JAK-STAT	IBA GO_REF:0000033	ACCEPT	Summary: Core JAK-STAT signaling role Reason: JAK1 is a core kinase component of cytokine receptor signaling via STAT transcription factors.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IBA GO_REF:0000033	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function. Supporting Evidence: file:mouse/Jak1/Jak1-notes.md JAK1 is a receptor-associated, non-receptor protein tyrosine kinase that phosphorylates receptor tails and STAT proteins in cytokine signaling. file:mouse/Jak1/Jak1-deep-research-falcon.md Falcon synthesis supports Jak1 as a cytosolic non-receptor tyrosine kinase that mediates cytokine receptor signaling through receptor and STAT phosphorylation.
GO:0005829 cytosol	IBA GO_REF:0000033	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0019221 cytokine-mediated signaling pathway	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: cytokine-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: growth hormone receptor signaling pathway via JAK-STAT pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0035556 intracellular signal transduction	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: intracellular signal transduction pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0030154 cell differentiation	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: cell differentiation pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0005131 growth hormone receptor binding	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: growth hormone receptor binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function.
GO:0000166 nucleotide binding	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: nucleotide binding is less specific than JAK1 tyrosine kinase activity Reason: The term is true at a broad level but over-annotated because more specific JAK1 tyrosine kinase terms are present.
GO:0004672 protein kinase activity	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: protein kinase activity is less specific than JAK1 tyrosine kinase activity Reason: The term is true at a broad level but over-annotated because more specific JAK1 tyrosine kinase terms are present.
GO:0004713 protein tyrosine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function. Supporting Evidence: file:mouse/Jak1/Jak1-notes.md JAK1 is a receptor-associated, non-receptor protein tyrosine kinase that phosphorylates receptor tails and STAT proteins in cytokine signaling.
GO:0005524 ATP binding	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: ATP binding is less specific than JAK1 tyrosine kinase activity Reason: ATP binding is an accurate molecular function of the JAK1 kinase domain, but it is less informative than the tyrosine kinase activity terms that capture the catalytic function.
GO:0005737 cytoplasm	IEA GO_REF:0000117	ACCEPT	Summary: cytoplasm localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0012505 endomembrane system	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: endomembrane system pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0016020 membrane	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: Generic membrane annotation Reason: The term is too broad to add useful information for JAK1 relative to specific tyrosine kinase and JAK-STAT annotations.
GO:0016301 kinase activity	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: kinase activity is less specific than JAK1 tyrosine kinase activity Reason: The term is true at a broad level but over-annotated because more specific JAK1 tyrosine kinase terms are present.
GO:0016740 transferase activity	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: transferase activity is less specific than JAK1 tyrosine kinase activity Reason: The term is true at a broad level but over-annotated because more specific JAK1 tyrosine kinase terms are present.
GO:0019221 cytokine-mediated signaling pathway	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: cytokine-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0035556 intracellular signal transduction	IEA GO_REF:0000002	KEEP AS NON CORE	Summary: intracellular signal transduction pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0046872 metal ion binding	IEA GO_REF:0000043	MARK AS OVER ANNOTATED	Summary: metal ion binding is less specific than JAK1 tyrosine kinase activity Reason: The term is true at a broad level but over-annotated because more specific JAK1 tyrosine kinase terms are present.
GO:0098761 cellular response to interleukin-7	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: cellular response to interleukin-7 pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function. Supporting Evidence: file:mouse/Jak1/Jak1-notes.md JAK1 is a receptor-associated, non-receptor protein tyrosine kinase that phosphorylates receptor tails and STAT proteins in cytokine signaling.
GO:0005634 nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: nucleus pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0005737 cytoplasm	ISO GO_REF:0000119	ACCEPT	Summary: cytoplasm localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0006468 protein phosphorylation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein phosphorylation pathway context Reason: Protein phosphorylation is JAK1's direct catalytic output, but this broad process term is less informative than the specific STAT protein tyrosine phosphorylation and JAK-STAT signaling terms captured in core_functions.
GO:0007259 cell surface receptor signaling pathway via JAK-STAT	ISO GO_REF:0000119	ACCEPT	Summary: Core JAK-STAT signaling role Reason: JAK1 is a core kinase component of cytokine receptor signaling via STAT transcription factors.
GO:0009898 cytoplasmic side of plasma membrane	ISO GO_REF:0000119	ACCEPT	Summary: cytoplasmic side of plasma membrane localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0019221 cytokine-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cytokine-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0019903 protein phosphatase binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein phosphatase binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function.
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane	ISO GO_REF:0000119	ACCEPT	Summary: extrinsic component of cytoplasmic side of plasma membrane localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0031625 ubiquitin protein ligase binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: ubiquitin protein ligase binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function.
GO:0034112 positive regulation of homotypic cell-cell adhesion	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of homotypic cell-cell adhesion pathway context Reason: This term captures a downstream response or regulatory outcome of JAK1 signaling rather than the core kinase activity.
GO:0035723 interleukin-15-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-15-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0035771 interleukin-4-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-4-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0038110 interleukin-2-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-2-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0038113 interleukin-9-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-9-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0038154 interleukin-11-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-11-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0060333 type II interferon-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: type II interferon-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0060337 type I interferon-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: type I interferon-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0070102 interleukin-6-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-6-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0140105 interleukin-10-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-10-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0150105 protein localization to cell-cell junction	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: protein localization to cell-cell junction pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:1900182 positive regulation of protein localization to nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of protein localization to nucleus pathway context Reason: This term captures a downstream response or regulatory outcome of JAK1 signaling rather than the core kinase activity.
GO:1903672 positive regulation of sprouting angiogenesis	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: positive regulation of sprouting angiogenesis pathway context Reason: This term captures a downstream response or regulatory outcome of JAK1 signaling rather than the core kinase activity.
GO:0005515 protein binding	IPI PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OS...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding is too generic to describe JAK1 function and should not be used as an informative functional annotation. Supporting Evidence: PMID:8272873 Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
GO:0005131 growth hormone receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: growth hormone receptor binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function.
GO:0006357 regulation of transcription by RNA polymerase II	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: regulation of transcription by RNA polymerase II pathway context Reason: This term captures a downstream response or regulatory outcome of JAK1 signaling rather than the core kinase activity.
GO:0030154 cell differentiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: cell differentiation pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0031730 CCR5 chemokine receptor binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: CCR5 chemokine receptor binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function.
GO:0038111 interleukin-7-mediated signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: interleukin-7-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0043235 receptor complex	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: receptor complex pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9674908	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function.
GO:0004713 protein tyrosine kinase activity	TAS Reactome:R-MMU-9674921	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function.
GO:0007259 cell surface receptor signaling pathway via JAK-STAT	ISS GO_REF:0000024	ACCEPT	Summary: Core JAK-STAT signaling role Reason: JAK1 is a core kinase component of cytokine receptor signaling via STAT transcription factors.
GO:0098761 cellular response to interleukin-7	IDA PMID:29581031 IL-7-induced phosphorylation of the adaptor Crk-like and oth...	UNDECIDED	Summary: PMID:29581031 supports IL-7-induced phosphorylation of Crk/CrkL targets in the cached abstract, but does not directly mention Jak1. Reason: Direct Jak1 dependence would need full-text or additional evidence.
GO:0004713 protein tyrosine kinase activity	IMP PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mic...	ACCEPT	Summary: Core JAK1 non-receptor tyrosine kinase activity Reason: JAK1 is a receptor-associated non-receptor tyrosine kinase and this term directly captures its catalytic molecular function. Supporting Evidence: PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mice.
GO:0007260 tyrosine phosphorylation of STAT protein	IMP PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mic...	ACCEPT	Summary: Direct STAT tyrosine phosphorylation activity Reason: JAK1 directly phosphorylates STAT proteins in cytokine receptor signaling, making this a direct output of its kinase activity. Supporting Evidence: PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mice.
GO:1904894 positive regulation of receptor signaling pathway via STAT	IMP PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mic...	ACCEPT	Summary: Core JAK-STAT signaling role Reason: JAK1 is a core kinase component of cytokine receptor signaling via STAT transcription factors. Supporting Evidence: PMID:27671227 Generation of Janus kinase 1 (JAK1) conditional knockout mice.
GO:0005829 cytosol	TAS Reactome:R-MMU-8983294	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-8983313	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-8983356	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9007126	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9007137	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9009867	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674900	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674908	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674921	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674931	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674959	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9674973	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9676072	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9705471	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9707972	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-9707979	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0036016 cellular response to interleukin-3	IDA PMID:8378315 Structure of the murine Jak2 protein-tyrosine kinase and its...	UNDECIDED	Summary: Cannot be adjudicated here: PMID:8378315 is cached abstract-only. Prior observation, not a verdict: PMID:8378315 supports Jak2 phosphorylation and activation after IL-3 stimulation, not Jak1 involvement in this IL-3 response. Reason: PMID:8378315 is cached abstract-only, so the curator's experimental evidence cannot be inspected here; per CLAUDE.md an experimental annotation is not overruled on that basis. Recorded observation, not a verdict: Cached evidence points to Jak2 rather than Jak1 for this pathway annotation.
GO:0038110 interleukin-2-mediated signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: interleukin-2-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity.
GO:0005515 protein binding	IPI PMID:15659653 The LIM/homeodomain protein Islet1 recruits Janus tyrosine k...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding is too generic to describe JAK1 function and should not be used as an informative functional annotation. Supporting Evidence: PMID:15659653 Jan 19. The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
GO:0005829 cytosol	TAS Reactome:R-MMU-1295758	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-1295764	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-1295768	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-MMU-8950409	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0005829 cytosol	TAS Reactome:R-NUL-1067645	ACCEPT	Summary: cytosol localization Reason: JAK1 is intracellular and receptor-associated at the cytoplasmic side of cytokine receptor complexes.
GO:0046677 response to antibiotic	ISO PMID:16280321 The heat shock protein 90-CDC37 chaperone complex is require...	KEEP AS NON CORE	Summary: response to antibiotic pathway context Reason: This term captures a downstream response or regulatory outcome of JAK1 signaling rather than the core kinase activity. Supporting Evidence: PMID:16280321 2005 Nov 9. The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
GO:0005131 growth hormone receptor binding	IPI PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and T...	KEEP AS NON CORE	Summary: growth hormone receptor binding interaction context Reason: This binding annotation reflects a receptor or regulator context for JAK1 but is not its core catalytic function. Supporting Evidence: PMID:10502458 The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
GO:0007167 enzyme-linked receptor protein signaling pathway	IDA PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by inter...	KEEP AS NON CORE	Summary: enzyme-linked receptor protein signaling pathway pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function. Supporting Evidence: PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
GO:0019221 cytokine-mediated signaling pathway	IDA PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by inter...	KEEP AS NON CORE	Summary: cytokine-mediated signaling pathway pathway context Reason: This is a valid cytokine receptor context for JAK1, but individual ligand pathways are context-specific rather than the core molecular activity. Supporting Evidence: PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
GO:0035556 intracellular signal transduction	IDA PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by inter...	KEEP AS NON CORE	Summary: intracellular signal transduction pathway context Reason: The annotation is compatible with JAK1 cytokine signaling biology but is not the core molecular function. Supporting Evidence: PMID:8022486 Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
GO:0004713 protein tyrosine kinase activity	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	ACCEPT	Summary: Core JAK1 tyrosine kinase activity; the cached record for PMID:10872802 is abstract-only and foregrounds the APS adaptor, which is a JAK substrate. Reason: The abstract-only cache does not show the Jak1 kinase experiment the MGI curator read in the full text, but APS/Lnk adaptors are JAK-binding substrates and protein tyrosine kinase activity is JAK1's core function, already accepted on IBA, IEA, ISO, TAS and IMP rows. Per the project rule, a clearly correct experimental annotation is accepted and deferred to the curator. Supporting Evidence: file:mouse/Jak1/Jak1-notes.md JAK1 is a receptor-associated, non-receptor protein tyrosine kinase that phosphorylates receptor tails and STAT proteins in cytokine signaling.
GO:0018108 peptidyl-tyrosine phosphorylation	IDA PMID:10872802 Molecular cloning of the mouse APS as a member of the Lnk fa...	ACCEPT	Summary: PMID:10872802 (abstract-only cache) shows APS tyrosine phosphorylation after IL-5, IL-3 or BCR stimulation and does not name the kinase; accepted by deferring to the MGI curator's full-text reading rather than on a mechanism visible in the cache. Reason: Peptidyl-tyrosine phosphorylation is the process counterpart of JAK1's accepted tyrosine kinase activity. The cached abstract-only record cannot show the full-text Jak1 experiment, and an abstract-only cache is not grounds to withhold agreement from a core experimental annotation. Supporting Evidence: file:mouse/Jak1/Jak1-notes.md JAK1 is a receptor-associated, non-receptor protein tyrosine kinase that phosphorylates receptor tails and STAT proteins in cytokine signaling.
GO:0005515 protein binding	IPI PMID:12738762 Fer is a downstream effector of insulin and mediates the act...	MARK AS OVER ANNOTATED	Summary: Generic protein binding Reason: Protein binding is too generic to describe JAK1 function and should not be used as an informative functional annotation. Supporting Evidence: PMID:12738762 May 8. Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.

Gene Description

Existing Annotations Review

Core Functions

JAK1 acts on the cytoplasmic side of cytokine receptor complexes as a non-receptor tyrosine kinase that phosphorylates receptor tails and STAT proteins.

References

Deep Research

Falcon

📚 Additional Documentation

Notes

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