Kras encodes KRas, a Ras-family small GTPase that functions as a lipid-anchored nucleotide switch. KRas cycles between inactive GDP-bound and active GTP-bound states, hydrolyzes GTP to GDP and phosphate, and transmits receptor-derived signals primarily from cytoplasmic membrane surfaces to RAF-MAPK and PI3K-AKT-mTOR effector pathways. Developmental and cancer phenotypes reflect perturbation of this core Ras signaling switch rather than separate primary molecular functions.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Cell membrane; Lipid-anchor; Cytoplasmic side |
| GO:0007265 Ras protein signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 file:mouse/Kras/Kras-deep-research-falcon.md KRas(ON) activates major growth and survival pathways, prominently RAS-RAF-MEK-ERK (MAPK) signaling |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch and GTP hydrolysis activity. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0003924 GTPase activity | IEA GO_REF:0000002 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch and GTP hydrolysis activity. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0003925 G protein activity | IEA GO_REF:0000003 | ACCEPT | Summary: G protein activity captures the core KRAS Ras-family nucleotide switch, with GTPase activity and GTP/GDP binding as the more specific mechanistic annotations. Reason: This is a valid broad molecular-function annotation for the core KRAS small GTPase switch, though GO:0003924, GO:0005525, and GO:0019003 are more specific. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005525 GTP binding | IEA GO_REF:0000002 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Plasma membrane localization is supported by UniProt/GO location evidence and is central to KRAS effector engagement. Reason: Plasma membrane association is a core cellular context for KRAS signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005886; C:plasma membrane; ISO:GO_Central. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | MODIFY | Summary: Generic signal transduction should be replaced by Ras protein signal transduction for KRAS. Reason: KRAS is a Ras-family GTPase switch; the broad signal-transduction parent is less precise than the supported Ras pathway term. Proposed replacements: Ras protein signal transduction |
| GO:0012505 endomembrane system | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0016020 membrane | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0005515 protein binding | IPI PMID:17229891 DYRK1A autophosphorylation on serine residue 520 modulates i... | MODIFY | Summary: IntAct KRAS-RAF1 (WITH/FROM P04049) record attributed to a study of DYRK1A autophosphorylation and 14-3-3 binding. Reason: The cached abstract concerns DYRK1A and does not describe Ras or RAF1; deferring to the IntAct curator (full text) for the KRAS-RAF1 interaction, which UniProt also lists. RAF1 is the canonical serine/threonine kinase effector engaged by GTP-bound Ras through its Ras-binding domain, so protein kinase binding is the informative MF (consistent with the human HRAS review). Proposed replacements: protein kinase binding Supporting Evidence: UniProt:P32883 P32883; P04049: RAF1; Xeno; NbExp=2 |
| GO:0005515 protein binding | IPI PMID:19164755 Identification of small-molecule inducers of pancreatic beta... | MODIFY | Summary: IntAct KRAS-RAF1 (WITH/FROM P04049) record attributed to a chemical screen for inducers of pancreatic beta-cell proliferation. Reason: The cached abstract does not describe Ras or RAF1; deferring to the IntAct curator (full text) for the KRAS-RAF1 interaction, which UniProt also lists. RAF1 is the canonical Ras effector kinase, so protein kinase binding is the informative MF. Proposed replacements: protein kinase binding Supporting Evidence: UniProt:P32883 P32883; P04049: RAF1; Xeno; NbExp=2 |
| GO:0005515 protein binding | IPI PMID:22975374 EGF receptor is required for KRAS-induced pancreatic tumorig... | REMOVE | Summary: Co-immunoprecipitation and colocalisation of oncogenic KRAS with EGFR (WITH/FROM Q01279) in KrasG12D pancreatic tumour cells; EGFR activity is required for KRAS-driven tumorigenesis. Reason: The co-IP places KRAS and EGFR in a common signalling complex, but EGFR acts upstream of Ras (via adaptors and GEFs) and no direct KRAS-EGFR binding mode or KRAS activity toward EGFR is shown, so protein kinase binding would overstate the evidence and no informative MF applies. Removal does not mean the reported interaction is false; the bare protein binding term simply carries no functional information about KRAS. Supporting Evidence: PMID:22975374 co-immunoprecipitation and co-immunofluorescence experiments showed clear interaction and colocalization of KRAS and EGFR in KrasG12D expressing tumor cell lines and acinar explants |
| GO:0007249 canonical NF-kappaB signal transduction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0012505 endomembrane system | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0007265 Ras protein signal transduction | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005829 cytosol | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0000164 protein phosphatase type 1 complex | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: The SHOC2/PP1 context is a regulatory complex interaction around Ras-MAPK signaling and should not be treated as a KRAS complex localization/function. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: COMPARTMENT OR COMPLEX MISMATCH |
| GO:0043406 positive regulation of MAP kinase activity | ISO GO_REF:0000096 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 file:mouse/Kras/Kras-deep-research-falcon.md KRas(ON) activates major growth and survival pathways, prominently RAS-RAF-MEK-ERK (MAPK) signaling |
| GO:0051000 positive regulation of nitric-oxide synthase activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0009898 cytoplasmic side of plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0010628 positive regulation of gene expression | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0019002 GMP binding | ISO GO_REF:0000096 | MODIFY | Summary: GMP binding is the wrong nucleotide specificity for KRAS and should be replaced by GTP and GDP binding. Reason: KRAS cycles between GTP-bound active and GDP-bound inactive states; local evidence supports GTP/GDP binding rather than GMP binding. Propagation Review Root cause: TERM SCOPING PROBLEM Proposed replacements: GTP binding GDP binding |
| GO:0019003 GDP binding | ISO GO_REF:0000096 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0019221 cytokine-mediated signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0030275 LRR domain binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: LRR-domain binding reflects a specific SHOC2-related regulatory interaction context and is too narrow and indirect to summarize KRAS function. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: GRANULARITY MISMATCH |
| GO:0042802 identical protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:2000774 positive regulation of cellular senescence | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0010467 gene expression | IMP PMID:29191600 Mig-6 deficiency cooperates with oncogenic Kras to promote m... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0009898 cytoplasmic side of plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0043495 protein-membrane adaptor activity | IDA PMID:12354753 Increased K-ras protein and activity in mouse and human lung... | UNDECIDED | Summary: MGI made this IDA from the full text of PMID:12354753; only the abstract is cached here, and it reports K-Ras p21 protein levels and GTP-loading at confluence without describing a membrane-tethering assay. Reason: The supporting evidence cannot be verified from the abstract-only cache, so the curator's experimental call is not overruled. Protein-membrane adaptor activity is an unusual molecular function for KRAS (which is itself lipid-anchored rather than an adaptor tethering other proteins), and full text is needed to confirm what was assayed. |
| GO:0048009 insulin-like growth factor receptor signaling pathway | ISO PMID:33302159 Functional dissection of the KRAS G12C mutation by compariso... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0048169 regulation of long-term neuronal synaptic plasticity | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0044877 protein-containing complex binding | ISO PMID:23209302 KIF14 negatively regulates Rap1a-Radil signaling during brea... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0007265 Ras protein signal transduction | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0010628 positive regulation of gene expression | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0021897 forebrain astrocyte development | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0048873 homeostasis of number of cells within a tissue | IGI PMID:24675817 Role of the protein tyrosine phosphatase Shp2 in homeostasis... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0045596 negative regulation of cell differentiation | IDA PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IDA PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IGI PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0016020 membrane | IDA PMID:10085069 Disruption of the mouse Rce1 gene results in defective Ras p... | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0016020 membrane | IGI PMID:14966563 Inactivation of Icmt inhibits transformation by oncogenic K-... | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9029152 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9682572 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-1250468 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-1250472 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005515 protein binding | IPI PMID:17404571 RASSF6 is a novel member of the RASSF family of tumor suppre... | REMOVE | Summary: The RASSF family tumour suppressor RASSF6 (WITH/FROM Q80UQ2) binds activated Ras through its Ras-association domain. Reason: RASSF6 is a non-catalytic Ras-association-domain effector; no more specific KRAS molecular function term applies (consistent with the RASSF rows in the human HRAS review). Removal does not mean the reported interaction is false; the bare protein binding term simply carries no functional information about KRAS. Supporting Evidence: PMID:17404571 RASSF6 possesses a Ras Association domain and binds activated Ras |
| GO:0003924 GTPase activity | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0007265 Ras protein signal transduction | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0030036 actin cytoskeleton organization | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0035022 positive regulation of Rac protein signal transduction | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0008542 visual learning | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0032228 regulation of synaptic transmission, GABAergic | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0043524 negative regulation of neuron apoptotic process | IGI PMID:10845775 Neurofibromin negatively regulates neurotrophin signaling th... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0051146 striated muscle cell differentiation | IGI PMID:15542848 Genetic interaction between Rb and K-ras in the control of d... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | TAS PMID:10498879 Transgenic models of lymphoid neoplasia and development of a... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0007265 Ras protein signal transduction | TAS PMID:10498879 Transgenic models of lymphoid neoplasia and development of a... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
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