Kras encodes KRas, a Ras-family small GTPase that functions as a lipid-anchored nucleotide switch. KRas cycles between inactive GDP-bound and active GTP-bound states, hydrolyzes GTP to GDP and phosphate, and transmits receptor-derived signals primarily from cytoplasmic membrane surfaces to RAF-MAPK and PI3K-AKT-mTOR effector pathways. Developmental and cancer phenotypes reflect perturbation of this core Ras signaling switch rather than separate primary molecular functions.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Cell membrane; Lipid-anchor; Cytoplasmic side |
| GO:0007265 Ras protein signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 file:mouse/Kras/Kras-deep-research-falcon.md KRas(ON) activates major growth and survival pathways, prominently RAS-RAF-MEK-ERK (MAPK) signaling |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch and GTP hydrolysis activity. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0003924 GTPase activity | IEA GO_REF:0000002 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch and GTP hydrolysis activity. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0003925 G protein activity | IEA GO_REF:0000003 | ACCEPT | Summary: G protein activity captures the core KRAS Ras-family nucleotide switch, with GTPase activity and GTP/GDP binding as the more specific mechanistic annotations. Reason: This is a valid broad molecular-function annotation for the core KRAS small GTPase switch, though GO:0003924, GO:0005525, and GO:0019003 are more specific. Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005525 GTP binding | IEA GO_REF:0000002 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Plasma membrane localization is supported by UniProt/GO location evidence and is central to KRAS effector engagement. Reason: Plasma membrane association is a core cellular context for KRAS signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005886; C:plasma membrane; ISO:GO_Central. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0007165 signal transduction | IEA GO_REF:0000002 | MODIFY | Summary: Generic signal transduction should be replaced by Ras protein signal transduction for KRAS. Reason: KRAS is a Ras-family GTPase switch; the broad signal-transduction parent is less precise than the supported Ras pathway term. Proposed replacements: Ras protein signal transduction |
| GO:0012505 endomembrane system | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0016020 membrane | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0005515 protein binding | IPI PMID:17229891 DYRK1A autophosphorylation on serine residue 520 modulates i... | MARK AS OVER ANNOTATED | Summary: This annotation is too generic or imprecise for KRAS; specific GTPase, GTP/GDP binding, membrane localization, and Ras signaling terms better capture the supported function. Reason: Term is too generic or less specific than the supported KRAS GTPase/nucleotide-binding activity |
| GO:0005515 protein binding | IPI PMID:19164755 Identification of small-molecule inducers of pancreatic beta... | MARK AS OVER ANNOTATED | Summary: This annotation is too generic or imprecise for KRAS; specific GTPase, GTP/GDP binding, membrane localization, and Ras signaling terms better capture the supported function. Reason: Term is too generic or less specific than the supported KRAS GTPase/nucleotide-binding activity |
| GO:0005515 protein binding | IPI PMID:22975374 EGF receptor is required for KRAS-induced pancreatic tumorig... | MARK AS OVER ANNOTATED | Summary: This annotation is too generic or imprecise for KRAS; specific GTPase, GTP/GDP binding, membrane localization, and Ras signaling terms better capture the supported function. Reason: Term is too generic or less specific than the supported KRAS GTPase/nucleotide-binding activity |
| GO:0007249 canonical NF-kappaB signal transduction | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0012505 endomembrane system | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0007265 Ras protein signal transduction | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005829 cytosol | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0000164 protein phosphatase type 1 complex | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: The SHOC2/PP1 context is a regulatory complex interaction around Ras-MAPK signaling and should not be treated as a KRAS complex localization/function. |
| GO:0043406 positive regulation of MAP kinase activity | ISO GO_REF:0000096 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 file:mouse/Kras/Kras-deep-research-falcon.md KRas(ON) activates major growth and survival pathways, prominently RAS-RAF-MEK-ERK (MAPK) signaling |
| GO:0051000 positive regulation of nitric-oxide synthase activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0009898 cytoplasmic side of plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0010628 positive regulation of gene expression | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0019002 GMP binding | ISO GO_REF:0000096 | MODIFY | Summary: GMP binding is the wrong nucleotide specificity for KRAS and should be replaced by GTP and GDP binding. Reason: KRAS cycles between GTP-bound active and GDP-bound inactive states; local evidence supports GTP/GDP binding rather than GMP binding. Proposed replacements: GTP binding GDP binding |
| GO:0019003 GDP binding | ISO GO_REF:0000096 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0019221 cytokine-mediated signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0030275 LRR domain binding | ISO GO_REF:0000096 | MARK AS OVER ANNOTATED | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: LRR-domain binding reflects a specific SHOC2-related regulatory interaction context and is too narrow and indirect to summarize KRAS function. |
| GO:0042802 identical protein binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:2000774 positive regulation of cellular senescence | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0010467 gene expression | IMP PMID:29191600 Mig-6 deficiency cooperates with oncogenic Kras to promote m... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0009898 cytoplasmic side of plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0043495 protein-membrane adaptor activity | IDA PMID:12354753 Increased K-ras protein and activity in mouse and human lung... | UNDECIDED | Summary: MGI made this IDA from the full text of PMID:12354753; only the abstract is cached here, and it reports K-Ras p21 protein levels and GTP-loading at confluence without describing a membrane-tethering assay. Reason: The supporting evidence cannot be verified from the abstract-only cache, so the curator's experimental call is not overruled. Protein-membrane adaptor activity is an unusual molecular function for KRAS (which is itself lipid-anchored rather than an adaptor tethering other proteins), and full text is needed to confirm what was assayed. |
| GO:0048009 insulin-like growth factor receptor signaling pathway | ISO PMID:33302159 Functional dissection of the KRAS G12C mutation by compariso... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0048169 regulation of long-term neuronal synaptic plasticity | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0044877 protein-containing complex binding | ISO PMID:23209302 KIF14 negatively regulates Rap1a-Radil signaling during brea... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0007265 Ras protein signal transduction | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0010628 positive regulation of gene expression | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0021897 forebrain astrocyte development | IMP PMID:22577135 Oncogenic Kras expression in postmitotic neurons leads to S1... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0048873 homeostasis of number of cells within a tissue | IGI PMID:24675817 Role of the protein tyrosine phosphatase Shp2 in homeostasis... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Broad cytoplasm localization is supported by the UniProt/GO location record, though KRAS signaling is more specifically associated with cytoplasmic membrane surfaces. Reason: Cytoplasm is a valid broad cellular-component annotation for KRAS, but the more informative localization is cytoplasmic side of the plasma membrane for membrane-proximal Ras signaling. Supporting Evidence: UniProt:P32883 DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. file:mouse/Kras/Kras-deep-research-falcon.md KRas signaling depends on **plasma membrane (PM) localization** and nanoscale **spatial organization** (nanoclustering), which creates a membrane environment that supports productive effector engagement. |
| GO:0045596 negative regulation of cell differentiation | IDA PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IDA PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0060441 epithelial tube branching involved in lung morphogenesis | IGI PMID:24058167 Lung epithelial branching program antagonizes alveolar diffe... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0016020 membrane | IDA PMID:10085069 Disruption of the mouse Rce1 gene results in defective Ras p... | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0016020 membrane | IGI PMID:14966563 Inactivation of Icmt inhibits transformation by oncogenic K-... | MARK AS OVER ANNOTATED | Summary: Generic membrane localization is less precise than KRAS plasma-membrane and cytoplasmic-side localization terms. Reason: KRAS membrane association is real, but the generic membrane term is less informative than the supported plasma membrane and cytoplasmic side of plasma membrane annotations. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9029152 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-MMU-9682572 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-1250468 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-1250472 | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0005515 protein binding | IPI PMID:17404571 RASSF6 is a novel member of the RASSF family of tumor suppre... | MARK AS OVER ANNOTATED | Summary: This annotation is too generic or imprecise for KRAS; specific GTPase, GTP/GDP binding, membrane localization, and Ras signaling terms better capture the supported function. Reason: Term is too generic or less specific than the supported KRAS GTPase/nucleotide-binding activity |
| GO:0003924 GTPase activity | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0007265 Ras protein signal transduction | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0030036 actin cytoskeleton organization | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0035022 positive regulation of Rac protein signal transduction | IGI PMID:15665300 Glioma formation in neurofibromatosis 1 reflects preferentia... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0008542 visual learning | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0032228 regulation of synaptic transmission, GABAergic | IGI PMID:11793011 Mechanism for the learning deficits in a mouse model of neur... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0043524 negative regulation of neuron apoptotic process | IGI PMID:10845775 Neurofibromin negatively regulates neurotrophin signaling th... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0051146 striated muscle cell differentiation | IGI PMID:15542848 Genetic interaction between Rb and K-ras in the control of d... | KEEP AS NON CORE | Summary: This annotation is compatible with KRAS biology, but represents a downstream phenotype, pathway context, interaction, or broad localization rather than the core molecular switch. Reason: Valid contextual annotation, but downstream or accessory to the core KRAS nucleotide-switch function |
| GO:0003924 GTPase activity | TAS PMID:10498879 Transgenic models of lymphoid neoplasia and development of a... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
| GO:0007265 Ras protein signal transduction | TAS PMID:10498879 Transgenic models of lymphoid neoplasia and development of a... | ACCEPT | Summary: Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output. Reason: Core Ras-family GTPase switch and membrane-proximal signaling role Supporting Evidence: UniProt:P32883 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. file:mouse/Kras/Kras-deep-research-falcon.md Mouse KRas is a **Ras-family small GTPase (GTP hydrolase)** that acts as a nucleotide-dependent molecular switch: **KRas-GTP** recruits/activates effectors to drive signaling, while **KRas-GDP** is comparatively inactive. |
Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)