Mapk1

id: P63085
gene_symbol: Mapk1
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: Mapk1 encodes ERK2/p42 MAPK, a CMGC-family proline-directed serine/threonine
  protein kinase and terminal kinase of the canonical RAS-RAF-MEK-ERK cascade. MEK1/2
  activates ERK2 by dual phosphorylation of its TEY activation-loop motif, after which
  ERK2 phosphorylates cytosolic, nuclear, cytoskeletal, and membrane-proximal substrates
  selected by proline-directed motifs plus D/DEF docking interactions. Developmental,
  inflammatory, sensory, and disease-response annotations are retained as context-specific
  outputs when supported, but the core annotation is MAP kinase catalytic activity
  in ERK1/2 signaling.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000008
  title: Gene Ontology annotation by the MGI curatorial staff, curated orthology
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-rat orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
    links
  findings: []
- id: GO_REF:0000116
  title: Automatic Gene Ontology annotation based on Rhea mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-human orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10419510
  title: Interaction of mitogen-activated protein kinases with the kinase interaction
    motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains
    ERK2 in the cytoplasm.
  findings: []
- id: PMID:10704452
  title: A dual role of erbB2 in myelination and in expansion of the schwann cell
    precursor pool.
  findings: []
- id: PMID:11404397
  title: 'Beta-amyloid activates the mitogen-activated protein kinase cascade via
    hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms
    related to Alzheimer''s disease.'
  findings: []
- id: PMID:11684667
  title: Erk MAP kinase regulates branching morphogenesis in the developing mouse
    kidney.
  findings: []
- id: PMID:11726647
  title: Prolonged nuclear retention of activated extracellular signal-regulated protein
    kinase promotes cell death generated by oxidative toxicity or proteasome inhibition
    in a neuronal cell line.
  findings: []
- id: PMID:11841548
  title: Role of the nude gene in epithelial terminal differentiation.
  findings: []
- id: PMID:11854404
  title: Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun
    NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase
    XCL100 in Xenopus oocytes.
  findings: []
- id: PMID:11884367
  title: 'Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart:
    enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation
    in PKCepsilon-induced cardioprotection.'
  findings: []
- id: PMID:12223545
  title: Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing
    extracellular signal-regulated kinase activation after transient focal cerebral
    ischemia in mice.
  findings: []
- id: PMID:12721286
  title: A novel RNA polymerase II C-terminal domain phosphatase that preferentially
    dephosphorylates serine 5.
  findings: []
- id: PMID:12808090
  title: Gab1 is an integrator of cell death versus cell survival signals in oxidative
    stress.
  findings: []
- id: PMID:12821670
  title: A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation
    in pseudopodia during protease-activated receptor-2-induced chemotaxis.
  findings: []
- id: PMID:12872135
  title: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
  findings: []
- id: PMID:12925581
  title: Spatial and temporal patterns of ERK signaling during mouse embryogenesis.
  findings: []
- id: PMID:14622137
  title: Essential role for ERK2 mitogen-activated protein kinase in placental development.
  findings: []
- id: PMID:14636584
  title: Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth
    factor-stimulated epithelial morphogenesis.
  findings: []
- id: PMID:14744933
  title: 'Suppression of mitochondrial respiration through recruitment of p160 myb
    binding protein to PGC-1alpha: modulation by p38 MAPK.'
  findings: []
- id: PMID:14970190
  title: Amylin inhibits bone resorption while the calcitonin receptor controls bone
    formation in vivo.
  findings: []
- id: PMID:14997210
  title: 'Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated
    chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study
    in the 5T33MM model.'
  findings: []
- id: PMID:15102471
  title: Bioinformatics and cellular signaling.
  findings: []
- id: PMID:15196959
  title: The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate
    mesoderm cell fate.
  findings: []
- id: PMID:15284227
  title: MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein
    kinase CK2alpha.
  findings: []
- id: PMID:15314156
  title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by
    binding to a multifunctional docking site of met.
  findings: []
- id: PMID:15383658
  title: p53-dependent inhibition of FKHRL1 in response to DNA damage through protein
    kinase SGK1.
  findings: []
- id: PMID:15537391
  title: Vanishin is a novel ubiquitinylated death-effector domain protein that blocks
    ERK activation.
  findings: []
- id: PMID:15544353
  title: Treatment of cells with the angiogenic inhibitor fumagillin results in increased
    stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and
    reduced phosphorylation of extracellular signal-regulated kinases.
  findings: []
- id: PMID:15896720
  title: Presenilin acts as a positive regulator of basal level activity of ERK through
    the Raf-MEK1 signaling pathway.
  findings: []
- id: PMID:16148006
  title: ERK2 shows a restrictive and locally selective mechanism of recognition by
    its tyrosine phosphatase inactivators not shared by its activator MEK1.
  findings: []
- id: PMID:16251435
  title: Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic
    plasticity and spatial memory.
  findings: []
- id: PMID:1659995
  title: Functional expression in mammalian cells of a full-length cDNA coding for
    the pp42/MAP kinase (p42mapk) protein.
  findings: []
- id: PMID:17187070
  title: Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing
    T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
  findings: []
- id: PMID:18045539
  title: 'Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1
    signal.'
  findings: []
- id: PMID:18084034
  title: ERK is a novel regulatory kinase for poly(A) polymerase.
  findings: []
- id: PMID:18241670
  title: 'Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase
    2-binding protein in testis.'
  findings: []
- id: PMID:18590835
  title: Identification of ERK2-binding domain of EBITEIN1, a novel ERK2-binding protein.
  findings: []
- id: PMID:18604197
  title: IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
  findings: []
- id: PMID:18760695
  title: Neuregulin-1/ErbB signaling serves distinct functions in myelination of the
    peripheral and central nervous system.
  findings: []
- id: PMID:18952847
  title: Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling
    in neural crest development.
  findings: []
- id: PMID:19047410
  title: Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12
    production by Giardia lamblia.
  findings: []
- id: PMID:19455133
  title: Targeted tandem affinity purification of PSD-95 recovers core postsynaptic
    complexes and schizophrenia susceptibility proteins.
  findings: []
- id: PMID:19565474
  title: The ERK signaling cascade--views from different subcellular compartments.
  findings: []
- id: PMID:20053668
  title: Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by
    affecting both osteoblastogenesis and osteoclastogenesis.
  findings: []
- id: PMID:20056832
  title: Acute insulin signaling in pancreatic beta-cells is mediated by multiple
    Raf-1 dependent pathways.
  findings: []
- id: PMID:20418913
  title: The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development
    and progression.
  findings: []
- id: PMID:20554783
  title: Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein
    kinase extracellular-regulated kinase (ERK) to membranes through interaction with
    the ERK common docking domain.
  findings: []
- id: PMID:20661302
  title: Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing
    NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.
  findings: []
- id: PMID:21220101
  title: Specific functions for ERK/MAPK signaling during PNS development.
  findings: []
- id: PMID:22451653
  title: Siglec-15 protein regulates formation of functional osteoclasts in concert
    with DNAX-activating protein of 12 kDa (DAP12).
  findings: []
- id: PMID:23644467
  title: The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate
    breast cancer metastasis.
  findings: []
- id: PMID:24349514
  title: MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin
    effect in C2C12 muscle cells.
  findings: []
- id: PMID:24381169
  title: α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R)
    to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
  findings: []
- id: PMID:24431450
  title: Shp2-dependent ERK signaling is essential for induction of Bergmann glia
    and foliation of the cerebellum.
  findings: []
- id: PMID:24493648
  title: Activation of MAPK overrides the termination of myelin growth and replaces
    Nrg1/ErbB3 signals during Schwann cell development and myelination.
  findings: []
- id: PMID:25100655
  title: Crucial requirement of ERK/MAPK signaling in respiratory tract development.
  findings: []
- id: PMID:26240334
  title: FXR1P is a GSK3β substrate regulating mood and emotion processing.
  findings: []
- id: PMID:26267534
  title: Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK
    Pathway Oncogenes.
  findings: []
- id: PMID:26375174
  title: Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor,
    mZnR/GPR39.
  findings: []
- id: PMID:27822540
  title: Identification of Novel Host Interactors of Effectors Secreted by Salmonella
    and Citrobacter.
  findings: []
- id: PMID:28671696
  title: Spatiotemporal profile of postsynaptic interactomes integrates components
    of complex brain disorders.
  findings: []
- id: PMID:31898284
  title: CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling
    Pathway After Intracerebral Hemorrhage in Mice.
  findings: []
- id: PMID:33331896
  title: Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
  findings: []
- id: PMID:38198890
  title: Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake
    to promote muscle regeneration.
  findings: []
- id: PMID:8221888
  title: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase
    that dephosphorylates MAP kinase in vivo.
  findings: []
- id: PMID:8626447
  title: Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid
    cell line by expressing the Syk protein-tyrosine kinase.
  findings: []
- id: PMID:8828504
  title: Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular
    signaling pathways.
  findings: []
- id: PMID:9064344
  title: Signaling capacity of the T cell antigen receptor is negatively regulated
    by the PTP1C tyrosine phosphatase.
  findings: []
- id: PMID:9254656
  title: The motheaten mutation rescues B cell signaling and development in CD45-deficient
    mice.
  findings: []
- id: PMID:9447983
  title: A novel, multifuntional c-Cbl binding protein in insulin receptor signaling
    in 3T3-L1 adipocytes.
  findings: []
- id: Reactome:R-MMU-198706
  title: ERK1/2 activates ELK1
  findings: []
- id: Reactome:R-MMU-9769840
  title: Mapk1,(Mapk3) phosphorylate Npas4
  findings: []
- id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
  title: Falcon deep research summary for mouse Mapk1
  findings: []
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: intracellular signal transduction is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - &id001
      id: GO:0070371
      label: ERK1 and ERK2 cascade
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: cell surface receptor signaling pathway is a broad parent for ERK1/2
      signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: phosphotyrosine residue binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0001890
    label: placenta development
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: placenta development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: protein kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - &id002
      id: GO:0004707
      label: MAP kinase activity
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: ATP binding is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: early endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: late endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: Golgi apparatus is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: centrosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: spindle is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005901
    label: caveola
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: caveola is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: focal adhesion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0006357
    label: regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: regulation of transcription by RNA polymerase II lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031143
    label: pseudopodium
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: pseudopodium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0035094
    label: response to nicotine
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: response to nicotine lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042473
    label: outer ear morphogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: outer ear morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0043330
    label: response to exogenous dsRNA
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: response to exogenous dsRNA lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of cytoskeleton organization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060020
    label: Bergmann glial cell differentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: Bergmann glial cell differentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061308
    label: cardiac neural crest cell development involved in heart development
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cardiac neural crest cell development involved in heart development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071356
    label: cellular response to tumor necrosis factor
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cellular response to tumor necrosis factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071375
    label: cellular response to peptide hormone stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cellular response to peptide hormone stimulus lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071396
    label: cellular response to lipid
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cellular response to lipid lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: caveolin-mediated endocytosis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of Golgi inheritance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000116
  review:
    summary: protein serine kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: positive regulation of neuroinflammatory response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of early endosome to late endosome transport lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10419510
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15102471
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16148006
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18045539
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19455133
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20554783
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23644467
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27822540
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28671696
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IPI
  original_reference_id: PMID:26267534
  review:
    summary: ERK dimerization is directly supported by PMID:26267534, but identical protein binding is a secondary signaling-state property rather than the core ERK2 kinase function.
    action: KEEP_AS_NON_CORE
    reason: The cached publication explicitly states that activated ERK dimerizes. Retain as supported non-core biology instead of leaving the accessible IPI evidence undecided.
    supported_by:
    - reference_id: PMID:26267534
      supporting_text: Upon activation, ERK dimerize, which is essential for ERK extranuclear,
        but not for nuclear, signaling
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: epidermal growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phosphatase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to amino acid starvation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0038127
    label: ERBB signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: ERBB signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: ERK dimerization is directly supported by PMID:26267534, but identical protein binding is a secondary signaling-state property rather than the core ERK2 kinase function.
    action: KEEP_AS_NON_CORE
    reason: Retain as supported non-core biology; the core molecular function remains ERK MAP kinase activity and protein phosphorylation.
    supported_by:
    - reference_id: PMID:26267534
      supporting_text: Upon activation, ERK dimerize, which is essential for ERK extranuclear,
        but not for nuclear, signaling
- term:
    id: GO:0045542
    label: positive regulation of cholesterol biosynthetic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of cholesterol biosynthetic process lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045880
    label: positive regulation of smoothened signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of smoothened signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: interleukin-34-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: ERK1 and ERK2 cascade is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:38198890
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0043415
    label: positive regulation of skeletal muscle tissue regeneration
  evidence_type: IMP
  original_reference_id: PMID:38198890
  review:
    summary: positive regulation of skeletal muscle tissue regeneration lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein-containing complex lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: protein serine kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0045880
    label: positive regulation of smoothened signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: positive regulation of smoothened signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-198706
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9769840
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0010800
    label: positive regulation of peptidyl-threonine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of peptidyl-threonine phosphorylation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: peptidyl-serine phosphorylation is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0097542
    label: ciliary tip
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ciliary tip lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0003690
    label: double-stranded DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: double-stranded DNA binding is not a defensible core ERK annotation.
    action: MARK_AS_OVER_ANNOTATED
    reason: The Falcon synthesis supports ERK as a proline-directed protein kinase
      in MAPK signaling; this term is too indirect, too broad, or mechanistically
      mismatched for the gene product.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: ATP binding is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: plasma membrane lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: caveola lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005929
    label: cilium
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cilium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: epidermal growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0009636
    label: response to toxic substance
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: response to toxic substance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0010759
    label: positive regulation of macrophage chemotaxis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of macrophage chemotaxis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: postsynaptic density lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0015630
    label: microtubule cytoskeleton
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: microtubule cytoskeleton lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0015966
    label: diadenosine tetraphosphate biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: diadenosine tetraphosphate biosynthetic process is not a defensible core
      ERK annotation.
    action: MARK_AS_OVER_ANNOTATED
    reason: The Falcon synthesis supports ERK as a proline-directed protein kinase
      in MAPK signaling; this term is too indirect, too broad, or mechanistically
      mismatched for the gene product.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0019233
    label: sensory perception of pain
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: sensory perception of pain lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein kinase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phosphatase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030424
    label: axon
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: axon lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031435
    label: mitogen-activated protein kinase kinase kinase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: mitogen-activated protein kinase kinase kinase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032206
    label: positive regulation of telomere maintenance
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of telomere maintenance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032839
    label: dendrite cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: dendrite cytoplasm lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to amino acid starvation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0035094
    label: response to nicotine
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: response to nicotine lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: intracellular signal transduction is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0036064
    label: ciliary basal body
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ciliary basal body lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0038127
    label: ERBB signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ERBB signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042307
    label: positive regulation of protein import into nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of protein import into nucleus lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ERK dimerization is directly supported by PMID:26267534, but identical protein binding is a secondary signaling-state property rather than the core ERK2 kinase function.
    action: KEEP_AS_NON_CORE
    reason: Retain as supported non-core biology; the core molecular function remains ERK MAP kinase activity and protein phosphorylation.
    supported_by:
    - reference_id: PMID:26267534
      supporting_text: Upon activation, ERK dimerize, which is essential for ERK extranuclear,
        but not for nuclear, signaling
- term:
    id: GO:0043204
    label: perikaryon
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: perikaryon lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0043627
    label: response to estrogen
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: response to estrogen lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045542
    label: positive regulation of cholesterol biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of cholesterol biosynthetic process lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045727
    label: positive regulation of translation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of translation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045893
    label: positive regulation of DNA-templated transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of DNA-templated transcription lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0046697
    label: decidualization
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: decidualization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060045
    label: positive regulation of cardiac muscle cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of cardiac muscle cell proliferation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: interleukin-34-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: ERK1 and ERK2 cascade is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ERK1 and ERK2 cascade is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0097237
    label: cellular response to toxic substance
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cellular response to toxic substance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0120041
    label: positive regulation of macrophage proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of macrophage proliferation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18590835
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: IDA
  original_reference_id: PMID:31898284
  review:
    summary: positive regulation of neuroinflammatory response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20418913
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: PMID:33331896
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22451653
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:26240334
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0048009
    label: insulin-like growth factor receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:14997210
  review:
    summary: insulin-like growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0048009
    label: insulin-like growth factor receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:24381169
  review:
    summary: insulin-like growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISO
  original_reference_id: PMID:8828504
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:1659995
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0008286
    label: insulin receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:20056832
  review:
    summary: insulin receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0014044
    label: Schwann cell development
  evidence_type: IMP
  original_reference_id: PMID:10704452
  review:
    summary: Schwann cell development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042552
    label: myelination
  evidence_type: IMP
  original_reference_id: PMID:10704452
  review:
    summary: myelination lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042552
    label: myelination
  evidence_type: IMP
  original_reference_id: PMID:18760695
  review:
    summary: myelination lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0038133
    label: ERBB2-ERBB3 signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:24493648
  review:
    summary: ERBB2-ERBB3 signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IGI
  original_reference_id: PMID:21220101
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-198706
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9769840
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15537391
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IPI
  original_reference_id: PMID:8221888
  review:
    summary: phosphatase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071356
    label: cellular response to tumor necrosis factor
  evidence_type: IGI
  original_reference_id: PMID:24349514
  review:
    summary: cellular response to tumor necrosis factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IMP
  original_reference_id: PMID:26375174
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0051453
    label: regulation of intracellular pH
  evidence_type: IMP
  original_reference_id: PMID:26375174
  review:
    summary: regulation of intracellular pH lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: plasma membrane lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: caveola lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0035094
    label: response to nicotine
  evidence_type: IGI
  original_reference_id: PMID:11404397
  review:
    summary: response to nicotine lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:20554783
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:20554783
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0030278
    label: regulation of ossification
  evidence_type: IGI
  original_reference_id: PMID:20053668
  review:
    summary: regulation of ossification lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0007507
    label: heart development
  evidence_type: IMP
  original_reference_id: PMID:18952847
  review:
    summary: heart development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0014032
    label: neural crest cell development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: neural crest cell development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030878
    label: thyroid gland development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: thyroid gland development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042473
    label: outer ear morphogenesis
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: outer ear morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0048538
    label: thymus development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: thymus development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060324
    label: face development
  evidence_type: IMP
  original_reference_id: PMID:18952847
  review:
    summary: face development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060324
    label: face development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: face development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061308
    label: cardiac neural crest cell development involved in heart development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: cardiac neural crest cell development involved in heart development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060020
    label: Bergmann glial cell differentiation
  evidence_type: IGI
  original_reference_id: PMID:24431450
  review:
    summary: Bergmann glial cell differentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IGI
  original_reference_id: PMID:19047410
  review:
    summary: ERK1 and ERK2 cascade is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0060425
    label: lung morphogenesis
  evidence_type: IGI
  original_reference_id: PMID:25100655
  review:
    summary: lung morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060440
    label: trachea formation
  evidence_type: IGI
  original_reference_id: PMID:25100655
  review:
    summary: trachea formation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060291
    label: long-term synaptic potentiation
  evidence_type: IGI
  original_reference_id: PMID:20661302
  review:
    summary: long-term synaptic potentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0072686
    label: mitotic spindle
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: mitotic spindle lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15196959
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11854404
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15544353
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15284227
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17187070
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18241670
  review:
    summary: protein binding records a physical association but is too generic to
      describe the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful
      standalone protein binding function; more informative molecular and pathway
      terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:18084034
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IMP
  original_reference_id: PMID:18084034
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:18084034
  review:
    summary: peptidyl-serine phosphorylation is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:18084034
  review:
    summary: peptidyl-serine phosphorylation is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: peptidyl-serine phosphorylation is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: mitochondrion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: early endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: late endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: Golgi apparatus is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: cytoskeleton is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005901
    label: caveola
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: caveola is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: focal adhesion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of cytoskeleton organization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: caveolin-mediated endocytosis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of Golgi inheritance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of early endosome to late endosome transport lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031143
    label: pseudopodium
  evidence_type: IDA
  original_reference_id: PMID:12821670
  review:
    summary: pseudopodium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IDA
  original_reference_id: PMID:11884367
  review:
    summary: mitochondrion lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:11884367
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0033598
    label: mammary gland epithelial cell proliferation
  evidence_type: IDA
  original_reference_id: PMID:18604197
  review:
    summary: mammary gland epithelial cell proliferation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11726647
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:12925581
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:11726647
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0008353
    label: RNA polymerase II CTD heptapeptide repeat kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12721286
  review:
    summary: RNA polymerase II CTD heptapeptide repeat kinase activity lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000008
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK
      MAP kinase activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0060716
    label: labyrinthine layer blood vessel development
  evidence_type: IMP
  original_reference_id: PMID:14622137
  review:
    summary: labyrinthine layer blood vessel development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:9447983
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:9254656
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:9064344
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:9254656
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0050853
    label: B cell receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9254656
  review:
    summary: B cell receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:9064344
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0050852
    label: T cell receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:9064344
  review:
    summary: T cell receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15896720
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:15896720
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0031663
    label: lipopolysaccharide-mediated signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: lipopolysaccharide-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032496
    label: response to lipopolysaccharide
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: response to lipopolysaccharide lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0043330
    label: response to exogenous dsRNA
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: response to exogenous dsRNA lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045596
    label: negative regulation of cell differentiation
  evidence_type: IGI
  original_reference_id: PMID:14970190
  review:
    summary: negative regulation of cell differentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:15284227
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15284227
  review:
    summary: kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0019858
    label: cytosine metabolic process
  evidence_type: IDA
  original_reference_id: PMID:15284227
  review:
    summary: cytosine metabolic process is not a defensible core ERK annotation.
    action: MARK_AS_OVER_ANNOTATED
    reason: The Falcon synthesis supports ERK as a proline-directed protein kinase
      in MAPK signaling; this term is too indirect, too broad, or mechanistically
      mismatched for the gene product.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:16251435
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15314156
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: IDA
  original_reference_id: PMID:15383658
  review:
    summary: DNA damage response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1
      and ERK2 cascade.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
        (ERK1/2 MAPK) cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8626447
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IMP
  original_reference_id: PMID:11841548
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:11841548
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:14744933
  review:
    summary: protein kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:14744933
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12808090
  review:
    summary: kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IMP
  original_reference_id: PMID:14636584
  review:
    summary: phosphotyrosine residue binding is supported in a specific HGF/paxillin cell-matrix
      interaction context, but is not the core ERK2 kinase function.
    action: KEEP_AS_NON_CORE
    reason: The cited evidence supports a context-specific tyrosine-phosphorylation-dependent
      ERK association.
    supported_by:
    - reference_id: PMID:14636584
      supporting_text: this is mediated by the tyrosine phosphorylation-dependent association
        of inactive ERK and the focal adhesion complex protein paxillin
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:12925581
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:12223545
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
        preferentially phosphorylating substrates containing **PX(S/T)P**
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:12223545
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
      supporting_text: ERK2 continuously exchanges between cytoplasm and nucleus
- term:
    id: GO:0009887
    label: animal organ morphogenesis
  evidence_type: IDA
  original_reference_id: PMID:11684667
  review:
    summary: animal organ morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
core_functions:
- description: ERK2 catalyzes proline-directed phosphorylation of protein substrates
    at serine/threonine residues after MEK-dependent activation-loop phosphorylation.
  molecular_function: *id002
  directly_involved_in:
  - id: GO:0006468
    label: protein phosphorylation
  - *id001
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005634
    label: nucleus
  supported_by:
  - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
    supporting_text: ERK2 is a **proline-directed serine/threonine protein kinase**,
      preferentially phosphorylating substrates containing **PX(S/T)P**
- description: Acts as a terminal kinase in the RAS-RAF-MEK-ERK pathway to translate
    growth factor and receptor signals into compartment-specific phosphorylation programs.
  molecular_function:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  directly_involved_in:
  - *id001
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005634
    label: nucleus
  supported_by:
  - reference_id: file:mouse/Mapk1/Mapk1-deep-research-falcon.md
    supporting_text: ERK2 is a terminal kinase in the canonical **RAS-RAF-MEK-ERK**
      (ERK1/2 MAPK) cascade
proposed_new_terms: []
suggested_questions:
- question: Which ERK2 substrate classes are sufficiently direct and recurring to
    support more specific substrate- or compartment-scoped GO-CAM modeling?
- question: Which Mapk1 developmental annotations remain valid when separated from
    overlapping ERK1 activity?
suggested_experiments:
- description: Map direct ERK2 substrates in cytosolic versus nuclear compartments
    after acute MEK activation using analog-sensitive or proximity-labeled ERK2 alleles.
  hypothesis: Mapk1 core function is shared MAP kinase catalysis, but biologically
    specific outputs depend on compartment-restricted substrate access.
  experiment_type: Compartment-resolved phosphoproteomics