id: Q63844
gene_symbol: Mapk3
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: Mapk3 encodes ERK1/p44 MAPK, a CMGC-family proline-directed serine/threonine
  protein kinase in the ERK1/2 branch of the RAS-RAF-MEK-ERK cascade. ERK1 is activated by
  MEK-mediated dual phosphorylation of the TEY activation-loop motif and phosphorylates many
  cytosolic and nuclear substrates selected by proline-directed motifs, D-motif/CD-site and
  DEF/FRS docking. ERK1 and ERK2 are closely related but not fully interchangeable in mouse;
  therefore direct kinase and ERK cascade terms are core, while developmental, immune, autophagy,
  neuronal, and stress-response phenotypes are curated as context-specific outputs.
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary
    mapping, accompanied by conservative changes to GO terms applied by UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat
    orthologs
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to orthologs
    using Ensembl Compara
  findings: []
- id: GO_REF:0000116
  title: Automatic Gene Ontology annotation based on Rhea mapping
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human
    orthologs
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10704452
  title: A dual role of erbB2 in myelination and in expansion of the schwann cell precursor
    pool.
  findings: []
- id: PMID:11254359
  title: 'Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons
    from a transgenic mouse.'
  findings: []
- id: PMID:11356865
  title: Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular
    signal-regulated kinase signaling required for inflammatory pain in mice.
  findings: []
- id: PMID:11684667
  title: Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney.
  findings: []
- id: PMID:11726647
  title: Prolonged nuclear retention of activated extracellular signal-regulated protein kinase
    promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal
    cell line.
  findings: []
- id: PMID:11841548
  title: Role of the nude gene in epithelial terminal differentiation.
  findings: []
- id: PMID:12062026
  title: Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates
    striatal-mediated learning and memory.
  findings: []
- id: PMID:12223545
  title: Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular
    signal-regulated kinase activation after transient focal cerebral ischemia in mice.
  findings: []
- id: PMID:12821670
  title: A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in
    pseudopodia during protease-activated receptor-2-induced chemotaxis.
  findings: []
- id: PMID:12872135
  title: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
  findings: []
- id: PMID:14636584
  title: Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated
    epithelial morphogenesis.
  findings: []
- id: PMID:14997210
  title: 'Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis,
    VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.'
  findings: []
- id: PMID:15314156
  title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding
    to a multifunctional docking site of met.
  findings: []
- id: PMID:15383658
  title: p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase
    SGK1.
  findings: []
- id: PMID:15537391
  title: Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK
    activation.
  findings: []
- id: PMID:15544353
  title: Treatment of cells with the angiogenic inhibitor fumagillin results in increased
    stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced
    phosphorylation of extracellular signal-regulated kinases.
  findings: []
- id: PMID:1717989
  title: Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential
    to phosphorylate tyrosine.
  findings: []
- id: PMID:17348861
  title: IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK,
    and Src-like tyrosine kinases.
  findings: []
- id: PMID:17644814
  title: Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells.
  findings: []
- id: PMID:18760695
  title: Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral
    and central nervous system.
  findings: []
- id: PMID:18952847
  title: Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling
    in neural crest development.
  findings: []
- id: PMID:19047410
  title: Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production
    by Giardia lamblia.
  findings: []
- id: PMID:19565474
  title: The ERK signaling cascade--views from different subcellular compartments.
  findings: []
- id: PMID:20037141
  title: Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage
    ABCA1 expression and cholesterol efflux.
  findings: []
- id: PMID:20053668
  title: Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting
    both osteoblastogenesis and osteoclastogenesis.
  findings: []
- id: PMID:20889126
  title: Insulin signaling to the glomerular podocyte is critical for normal kidney function.
  findings: []
- id: PMID:21220101
  title: Specific functions for ERK/MAPK signaling during PNS development.
  findings: []
- id: PMID:22033934
  title: TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular
    signal-regulated kinase (ERK) activation.
  findings: []
- id: PMID:22307056
  title: ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of
    Klf4.
  findings: []
- id: PMID:22451653
  title: Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating
    protein of 12 kDa (DAP12).
  findings: []
- id: PMID:24349514
  title: "MicroRNA-494, upregulated by tumor necrosis factor-\u03B1, desensitizes insulin\
    \ effect in C2C12 muscle cells."
  findings: []
- id: PMID:24431450
  title: Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation
    of the cerebellum.
  findings: []
- id: PMID:24493648
  title: Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3
    signals during Schwann cell development and myelination.
  findings: []
- id: PMID:25100655
  title: Crucial requirement of ERK/MAPK signaling in respiratory tract development.
  findings: []
- id: PMID:26375174
  title: Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor,
    mZnR/GPR39.
  findings: []
- id: PMID:31898284
  title: CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway
    After Intracerebral Hemorrhage in Mice.
  findings: []
- id: PMID:33331896
  title: Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
  findings: []
- id: Reactome:R-MMU-198706
  title: ERK1/2 activates ELK1
  findings: []
- id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
  title: Falcon deep research summary for mouse Mapk3
  findings: []
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: intracellular signal transduction is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - &id001
      id: GO:0070371
      label: ERK1 and ERK2 cascade
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0007166
    label: cell surface receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: cell surface receptor signaling pathway is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: phosphotyrosine residue binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: protein kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - &id002
      id: GO:0004707
      label: MAP kinase activity
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: ATP binding is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: mitochondrion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: early endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: late endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: Golgi apparatus is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cytoskeleton is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005901
    label: caveola
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: caveola is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: focal adhesion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0031143
    label: pseudopodium
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: pseudopodium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042473
    label: outer ear morphogenesis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: outer ear morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0043330
    label: response to exogenous dsRNA
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: response to exogenous dsRNA lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of cytoskeleton organization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060020
    label: Bergmann glial cell differentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: Bergmann glial cell differentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061308
    label: cardiac neural crest cell development involved in heart development
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cardiac neural crest cell development involved in heart development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071356
    label: cellular response to tumor necrosis factor
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: cellular response to tumor necrosis factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: caveolin-mediated endocytosis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of Golgi inheritance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000116
  review:
    summary: protein serine kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: regulation of early endosome to late endosome transport lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22307056
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0002841
    label: negative regulation of T cell mediated immune response to tumor cell
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of T cell mediated immune response to tumor cell lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005635
    label: nuclear envelope
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: nuclear envelope lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: epidermal growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: phosphatase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030509
    label: BMP signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: BMP signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to amino acid starvation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042770
    label: signal transduction in response to DNA damage
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: signal transduction in response to DNA damage lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: ERK dimerization is directly supported by PMID:26267534, but identical protein binding is a secondary signaling-state property rather than the core ERK1 kinase function.
    action: KEEP_AS_NON_CORE
    reason: Retain as supported non-core biology; the core molecular function remains ERK MAP kinase activity and protein phosphorylation.
    supported_by:
    - reference_id: PMID:26267534
      supporting_text: Upon activation, ERK dimerize, which is essential for ERK extranuclear,
        but not for nuclear, signaling
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of transcription by RNA polymerase II lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: interleukin-34-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070374
    label: positive regulation of ERK1 and ERK2 cascade
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: positive regulation of ERK1 and ERK2 cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070498
    label: interleukin-1-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: interleukin-1-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0071260
    label: cellular response to mechanical stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: cellular response to mechanical stimulus lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0140297
    label: DNA-binding transcription factor binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: DNA-binding transcription factor binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: positive regulation of neuroinflammatory response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: negative regulation of TORC1 signaling lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein-containing complex lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: protein serine kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-198706
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0016310
    label: phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: Phosphorylation is too broad for an ERK kinase annotation.
    action: MODIFY
    reason: The relevant process is protein phosphorylation catalyzed by ERK MAP kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - &id003
      id: GO:0006468
      label: protein phosphorylation
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: peptidyl-serine phosphorylation is consistent with core ERK MAP kinase activity,
      phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0031281
    label: positive regulation of cyclase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of cyclase activity lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0038083
    label: peptidyl-tyrosine autophosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: peptidyl-tyrosine autophosphorylation is not a defensible core ERK annotation.
    action: MARK_AS_OVER_ANNOTATED
    reason: The Falcon synthesis supports ERK as a proline-directed protein kinase in MAPK
      signaling; this term is too indirect, too broad, or mechanistically mismatched for the
      gene product.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0097542
    label: ciliary tip
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ciliary tip lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000045
    label: autophagosome assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: autophagosome assembly lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0002841
    label: negative regulation of T cell mediated immune response to tumor cell
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of T cell mediated immune response to tumor cell lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: ATP binding is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005635
    label: nuclear envelope
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: nuclear envelope lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: plasma membrane lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: caveola lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005929
    label: cilium
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cilium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0007173
    label: epidermal growth factor receptor signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: epidermal growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0009636
    label: response to toxic substance
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: response to toxic substance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0010507
    label: negative regulation of autophagy
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of autophagy lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of autophagy lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0010759
    label: positive regulation of macrophage chemotaxis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of macrophage chemotaxis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0015630
    label: microtubule cytoskeleton
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: microtubule cytoskeleton lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019902
    label: phosphatase binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: phosphatase binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030509
    label: BMP signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: BMP signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031669
    label: cellular response to nutrient levels
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to nutrient levels lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032206
    label: positive regulation of telomere maintenance
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of telomere maintenance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032435
    label: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of proteasomal ubiquitin-dependent protein catabolic process lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0034198
    label: cellular response to amino acid starvation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: cellular response to amino acid starvation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: intracellular signal transduction is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0036064
    label: ciliary basal body
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ciliary basal body lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0038202
    label: TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: TORC1 signaling lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042770
    label: signal transduction in response to DNA damage
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: signal transduction in response to DNA damage lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: ERK dimerization is directly supported by PMID:26267534, but identical protein binding is a secondary signaling-state property rather than the core ERK1 kinase function.
    action: KEEP_AS_NON_CORE
    reason: Retain as supported non-core biology; the core molecular function remains ERK MAP kinase activity and protein phosphorylation.
    supported_by:
    - reference_id: PMID:26267534
      supporting_text: Upon activation, ERK dimerize, which is essential for ERK extranuclear,
        but not for nuclear, signaling
- term:
    id: GO:0045727
    label: positive regulation of translation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: positive regulation of translation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of transcription by RNA polymerase II lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0046697
    label: decidualization
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: decidualization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0050821
    label: protein stabilization
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: protein stabilization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0050868
    label: negative regulation of T cell activation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of T cell activation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051403
    label: stress-activated MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061514
    label: interleukin-34-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: interleukin-34-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0065003
    label: protein-containing complex assembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: protein-containing complex assembly lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070374
    label: positive regulation of ERK1 and ERK2 cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of ERK1 and ERK2 cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070498
    label: interleukin-1-mediated signaling pathway
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: interleukin-1-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: scaffold protein binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0097237
    label: cellular response to toxic substance
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: cellular response to toxic substance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0120041
    label: positive regulation of macrophage proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of macrophage proliferation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0140297
    label: DNA-binding transcription factor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: DNA-binding transcription factor binding lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: positive regulation of neuroinflammatory response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:1904262
    label: negative regulation of TORC1 signaling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: negative regulation of TORC1 signaling lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0150078
    label: positive regulation of neuroinflammatory response
  evidence_type: IDA
  original_reference_id: PMID:31898284
  review:
    summary: positive regulation of neuroinflammatory response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0090370
    label: negative regulation of cholesterol efflux
  evidence_type: IMP
  original_reference_id: PMID:20037141
  review:
    summary: negative regulation of cholesterol efflux lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IMP
  original_reference_id: PMID:12062026
  review:
    summary: modulation of chemical synaptic transmission lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0050804
    label: modulation of chemical synaptic transmission
  evidence_type: IDA
  original_reference_id: PMID:12062026
  review:
    summary: modulation of chemical synaptic transmission lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IMP
  original_reference_id: PMID:12062026
  review:
    summary: glutamatergic synapse lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:12062026
  review:
    summary: glutamatergic synapse lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:1717989
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0048009
    label: insulin-like growth factor receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:14997210
  review:
    summary: insulin-like growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0048009
    label: insulin-like growth factor receptor signaling pathway
  evidence_type: ISO
  original_reference_id: PMID:17348861
  review:
    summary: insulin-like growth factor receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0008286
    label: insulin receptor signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:20889126
  review:
    summary: insulin receptor signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0014044
    label: Schwann cell development
  evidence_type: IMP
  original_reference_id: PMID:10704452
  review:
    summary: Schwann cell development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042552
    label: myelination
  evidence_type: IMP
  original_reference_id: PMID:10704452
  review:
    summary: myelination lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042552
    label: myelination
  evidence_type: IMP
  original_reference_id: PMID:18760695
  review:
    summary: myelination lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISO
  original_reference_id: PMID:33331896
  review:
    summary: protein serine/threonine kinase activity is consistent with core ERK MAP kinase
      activity, phosphorylation, cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0038133
    label: ERBB2-ERBB3 signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:24493648
  review:
    summary: ERBB2-ERBB3 signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: IGI
  original_reference_id: PMID:21220101
  review:
    summary: MAPK cascade is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-198706
  review:
    summary: nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14636584
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15537391
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
- term:
    id: GO:0071356
    label: cellular response to tumor necrosis factor
  evidence_type: IGI
  original_reference_id: PMID:24349514
  review:
    summary: cellular response to tumor necrosis factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IMP
  original_reference_id: PMID:26375174
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0051453
    label: regulation of intracellular pH
  evidence_type: IMP
  original_reference_id: PMID:26375174
  review:
    summary: regulation of intracellular pH lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: plasma membrane lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005901
    label: caveola
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: caveola lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030278
    label: regulation of ossification
  evidence_type: IGI
  original_reference_id: PMID:20053668
  review:
    summary: regulation of ossification lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:1904417
    label: positive regulation of xenophagy
  evidence_type: IGI
  original_reference_id: PMID:22033934
  review:
    summary: positive regulation of xenophagy lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0014032
    label: neural crest cell development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: neural crest cell development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0030878
    label: thyroid gland development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: thyroid gland development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0042473
    label: outer ear morphogenesis
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: outer ear morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0048538
    label: thymus development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: thymus development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060324
    label: face development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: face development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0061308
    label: cardiac neural crest cell development involved in heart development
  evidence_type: IGI
  original_reference_id: PMID:18952847
  review:
    summary: cardiac neural crest cell development involved in heart development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060020
    label: Bergmann glial cell differentiation
  evidence_type: IGI
  original_reference_id: PMID:24431450
  review:
    summary: Bergmann glial cell differentiation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: IGI
  original_reference_id: PMID:19047410
  review:
    summary: ERK1 and ERK2 cascade is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
- term:
    id: GO:0060425
    label: lung morphogenesis
  evidence_type: IGI
  original_reference_id: PMID:25100655
  review:
    summary: lung morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0060440
    label: trachea formation
  evidence_type: IGI
  original_reference_id: PMID:25100655
  review:
    summary: trachea formation lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: PMID:22451653
  review:
    summary: cytosol is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0070849
    label: response to epidermal growth factor
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: response to epidermal growth factor lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: mitochondrion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005769
    label: early endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: early endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005770
    label: late endosome
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: late endosome is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: Golgi apparatus is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005856
    label: cytoskeleton
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: cytoskeleton is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005901
    label: caveola
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: caveola is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0005925
    label: focal adhesion
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: focal adhesion is supported as ERK subcellular localization context but is not a core molecular activity.
    action: KEEP_AS_NON_CORE
    reason: PMID:19565474 supports ERK targeting to distinct subcellular compartments; retain this as non-core localization/context rather than the primary kinase function.
    supported_by:
    - reference_id: PMID:19565474
      supporting_text: targets at distinct subcellular compartments
- term:
    id: GO:0032872
    label: regulation of stress-activated MAPK cascade
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of stress-activated MAPK cascade lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0051493
    label: regulation of cytoskeleton organization
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of cytoskeleton organization lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0072584
    label: caveolin-mediated endocytosis
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: caveolin-mediated endocytosis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0090170
    label: regulation of Golgi inheritance
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of Golgi inheritance lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:2000641
    label: regulation of early endosome to late endosome transport
  evidence_type: TAS
  original_reference_id: PMID:19565474
  review:
    summary: regulation of early endosome to late endosome transport lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031143
    label: pseudopodium
  evidence_type: IDA
  original_reference_id: PMID:12821670
  review:
    summary: pseudopodium lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11254359
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11726647
  review:
    summary: nucleus is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:11726647
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15314156
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0051216
    label: cartilage development
  evidence_type: IDA
  original_reference_id: PMID:17644814
  review:
    summary: cartilage development lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0031663
    label: lipopolysaccharide-mediated signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: lipopolysaccharide-mediated signaling pathway lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0032496
    label: response to lipopolysaccharide
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: response to lipopolysaccharide lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0043330
    label: response to exogenous dsRNA
  evidence_type: IDA
  original_reference_id: PMID:12872135
  review:
    summary: response to exogenous dsRNA lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0019233
    label: sensory perception of pain
  evidence_type: IMP
  original_reference_id: PMID:11356865
  review:
    summary: sensory perception of pain lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15383658
  review:
    summary: protein kinase activity is less specific than ERK MAP kinase activity.
    action: MODIFY
    reason: MAPK1/MAPK3 are ERK-family MAP kinases with proline-directed serine/threonine
      protein kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - *id002
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:15383658
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: IDA
  original_reference_id: PMID:15383658
  review:
    summary: DNA damage response lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: IMP
  original_reference_id: PMID:11841548
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:11841548
  review:
    summary: protein phosphorylation is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15544353
  review:
    summary: protein binding records a physical association but is too generic to describe
      the gene product function.
    action: MARK_AS_OVER_ANNOTATED
    reason: The evidence supports regulated signaling-complex assembly, not a meaningful standalone
      protein binding function; more informative molecular and pathway terms capture the biology.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
- term:
    id: GO:0001784
    label: phosphotyrosine residue binding
  evidence_type: IMP
  original_reference_id: PMID:14636584
  review:
    summary: phosphotyrosine residue binding is supported in a specific HGF/paxillin cell-matrix
      interaction context, but is not the core ERK1 kinase function.
    action: KEEP_AS_NON_CORE
    reason: The cited evidence supports a context-specific tyrosine-phosphorylation-dependent
      ERK association.
    supported_by:
    - reference_id: PMID:14636584
      supporting_text: this is mediated by the tyrosine phosphorylation-dependent association
        of inactive ERK and the focal adhesion complex protein paxillin
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:12223545
  review:
    summary: cytoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade
      function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are described as present in **cytoplasmic, nuclear, and membrane-associated**
        pools.
- term:
    id: GO:0016310
    label: phosphorylation
  evidence_type: TAS
  original_reference_id: PMID:12223545
  review:
    summary: Phosphorylation is too broad for an ERK kinase annotation.
    action: MODIFY
    reason: The relevant process is protein phosphorylation catalyzed by ERK MAP kinase activity.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
    proposed_replacement_terms:
    - *id003
- term:
    id: GO:0004707
    label: MAP kinase activity
  evidence_type: TAS
  original_reference_id: PMID:11684667
  review:
    summary: MAP kinase activity is consistent with core ERK MAP kinase activity, phosphorylation,
      cascade function, or localization.
    action: ACCEPT
    reason: This term directly captures ERK catalytic activity, ERK cascade participation,
      protein phosphorylation, or canonical nucleo-cytoplasmic localization.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
        preference for **PX(S/T)P** motifs
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: TAS
  original_reference_id: PMID:11684667
  review:
    summary: signal transduction is a broad parent for ERK1/2 signaling.
    action: MODIFY
    reason: The more specific biological process for these ERK proteins is the ERK1 and ERK2
      cascade.
    supported_by:
    - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
      supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
    proposed_replacement_terms:
    - *id001
- term:
    id: GO:0009887
    label: animal organ morphogenesis
  evidence_type: IDA
  original_reference_id: PMID:11684667
  review:
    summary: animal organ morphogenesis lacks term-specific support in the currently available local evidence.
    action: UNDECIDED
    reason: The generic ERK context-dependence evidence does not justify retaining this
      specific annotation without direct support.
core_functions:
- description: ERK1 catalyzes proline-directed phosphorylation of protein substrates at serine/threonine
    residues after MEK-mediated dual activation-loop phosphorylation.
  molecular_function: *id002
  directly_involved_in:
  - *id003
  - *id001
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005634
    label: nucleus
  supported_by:
  - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
    supporting_text: ERK1/2 are **proline-directed Ser/Thr protein kinases**, with strong
      preference for **PX(S/T)P** motifs
- description: Acts with ERK2 as the final kinase tier of the RAS-RAF-MEK-ERK cascade, with
    output shaped by localization, docking motifs, and signal duration.
  molecular_function:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  directly_involved_in:
  - *id001
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005634
    label: nucleus
  supported_by:
  - reference_id: file:mouse/Mapk3/Mapk3-deep-research-falcon.md
    supporting_text: ERK1/2 function as the final kinases in the RAS-RAF-MEK-ERK cascade
proposed_new_terms: []
suggested_questions:
- question: Which ERK1 annotations should remain on Mapk3 when phenotypes are largely buffered
    by ERK2?
- question: Are nuclear import and compartment-specific ERK1 signaling mature enough for more
    specific GO annotation extensions?
suggested_experiments:
- description: Test ERK1-specific and ERK2-specific rescue in Mapk3/Mapk1 perturbation backgrounds
    across nuclear, cytosolic, and membrane-associated ERK reporters.
  hypothesis: ERK1 has partially redundant catalytic function but distinct localization/dynamics
    that determine a subset of Mapk3-specific annotations.
  experiment_type: Isoform-specific genetic rescue and live ERK biosensors