Mtor

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0004674 protein serine/threonine kinase activity	IBA GO_REF:0000033	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IBA GO_REF:0000033	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IBA GO_REF:0000033	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	IBA GO_REF:0000033	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038202 TORC1 signaling	IBA GO_REF:0000033	ACCEPT	Summary: mTORC1 signaling—phosphorylation of S6K1, 4E-BP1 and ULK1 to drive translation/growth and suppress autophagy—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC1 signaling. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0016242 negative regulation of macroautophagy	IBA GO_REF:0000033	ACCEPT	Summary: mTORC1 directly restrains macroautophagy by phosphorylating ULK1 and inhibiting the autophagy-initiation machinery when nutrients are abundant. Reason: Core; ULK1-mediated suppression of macroautophagy by mTORC1 (IMP/IBA). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0000139 Golgi membrane	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: mTOR associates peripherally with the cytoplasmic face of Golgi membranes; a minor location versus lysosomal/plasma-membrane sites. Reason: Secondary peripheral-membrane localization.
GO:0004674 protein serine/threonine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004715 non-membrane spanning protein tyrosine kinase activity	IEA GO_REF:0000003	REMOVE	Summary: Mislabels mTOR as a soluble tyrosine kinase; mTOR is a PIKK-family Ser/Thr kinase and any tyrosine activity is by-similarity speculation only. Reason: IEA electronic mis-mapping inconsistent with mTOR's Ser/Thr kinase identity.
GO:0005634 nucleus	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: mTOR shuttles to the nucleus and accumulates there under hypoxia; a regulated secondary localization beyond its cytoplasmic membrane sites. Reason: Regulated nuclear pool (EXP/IDA); secondary location.
GO:0005737 cytoplasm	IEA GO_REF:0000120	ACCEPT	Summary: mTOR is a cytoplasmic kinase that shuttles among lysosomal, ER and plasma-membrane surfaces and the cytosol/nucleus; cytoplasmic localization is experimentally established. Reason: Supported localization (EXP/ISS); mTOR carries out its kinase function in the cytoplasm. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005741 mitochondrial outer membrane	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: mTOR has been localized to the mitochondrial outer membrane and senses osmotic stress via mitochondrial dysfunction; a peripheral secondary location. Reason: Secondary localization (EXP) linked to stress sensing.
GO:0005765 lysosomal membrane	IEA GO_REF:0000120	ACCEPT	Summary: mTORC1 is recruited to and activated on the cytosolic face of the lysosomal membrane by Rag-Ragulator and Rheb, the principal site where mTOR integrates nutrient and growth-factor signals. Reason: Core localization for mTORC1 activation (UniProt: lysosome membrane, peripheral, cytoplasmic side). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005789 endoplasmic reticulum membrane	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: mTORC2 signals at the cytoplasmic face of the ER membrane; a real secondary location for mTOR complexes. Reason: Secondary membrane site for mTORC2.
GO:0005886 plasma membrane	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: mTORC2 is active at the plasma membrane where it phosphorylates AKT/PKC; a genuine secondary location for mTOR. Reason: mTORC2 plasma-membrane site; secondary to lysosomal mTORC1.
GO:0016301 kinase activity	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: Uninformative top-level kinase term; mTOR's activity is precisely captured by protein serine/threonine kinase activity (GO:0004674). Reason: Over-general MF superseded by the specific Ser/Thr kinase annotation.
GO:0016605 PML body	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: PML sequesters mTOR in nuclear PML bodies to repress mTORC1 (HIF1α translation control); a regulatory localization documented by IDA. Reason: Regulatory nuclear-body localization (IDA). Supporting Evidence: UniProt:Q9JLN9 Nucleus, PML body
GO:0019216 regulation of lipid metabolic process	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: mTOR regulates lipid metabolism via SREBP1/LPIN1 and mTORC2 lipogenic outputs; a broad metabolic regulatory role downstream of the kinase. Reason: Downstream metabolic regulation.
GO:0031346 positive regulation of cell projection organization	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: mTORC2 cytoskeletal control and mTORC1 translational control promote cell-projection/process formation; a downstream morphological output. Reason: Downstream cytoskeletal/translational output.
GO:0044877 protein-containing complex binding	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: Non-specific complex-binding term that does not describe mTOR's defined role within mTORC1/mTORC2. Reason: Generic binding term; superseded by complex annotations.
GO:0045335 phagocytic vesicle	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: mTOR localizes to phagosomes, relevant to phagosome maturation and innate-immune signaling; a peripheral compartment. Reason: Secondary vesicular localization.
GO:0045792 negative regulation of cell size	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Captures contexts where mTOR loss/inhibition reduces cell size or where mTOR feedback limits growth; the directionality opposite to its dominant pro-growth role. Reason: Context/loss-of-function readout of mTOR growth control.
GO:0048714 positive regulation of oligodendrocyte differentiation	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: mTOR signaling promotes oligodendrocyte differentiation and myelination programs; a downstream CNS differentiation role. Reason: Downstream CNS differentiation effect (IMP).
GO:0050795 regulation of behavior	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Broad behavioral regulation arising from mTOR's neuronal translation/plasticity roles; a pleiotropic downstream phenotype. Reason: Downstream pleiotropic behavioral role.
GO:0051155 positive regulation of striated muscle cell differentiation	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: mTOR supports striated-muscle differentiation via growth and translational programs; a downstream developmental output. Reason: Downstream muscle differentiation effect.
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000117	ACCEPT	Summary: mTOR regulates PI3K-AKT signaling both as the mTORC2 AKT-kinase and via mTORC1 feedback (GRB10/IRS), placing it as a direct regulator of this pathway. Reason: Core; mTOR directly sets AKT activity through mTORC2 and mTORC1 feedback. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	IEA GO_REF:0000116	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0120035 regulation of plasma membrane bounded cell projection organization	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: mTOR signaling shapes cell projections (neurites, protrusions) via cytoskeletal and translational outputs; a downstream morphogenetic role. Reason: Downstream morphogenetic effect of mTOR.
GO:0005515 protein binding	IPI PMID:12150926 Raptor, a binding partner of target of rapamycin (TOR), medi...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:16541103 mTOR-dependent stimulation of the association of eIF4G and e...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:18046414 mTOR controls mitochondrial oxidative function through a YY1...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:18566586 The mammalian target of rapamycin complex 2 controls folding...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:18664580 mTORC1 promotes survival through translational control of Mc...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:20801936 Tel2 structure and function in the Hsp90-dependent maturatio...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:21045808 mTORC2 can associate with ribosomes to promote cotranslation...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:22307628 Glycerolipid signals alter mTOR complex 2 (mTORC2) to dimini...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:23966835 Reduced juvenile long-term depression in tuberous sclerosis ...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:24036451 PIH1D1 interacts with mTOR complex 1 and enhances ribosome R...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:25686248 Huntingtin functions as a scaffold for selective macroautoph...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005515 protein binding	IPI PMID:25980607 Phosphorylation of ULK1 by AMPK regulates translocation of U...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0000139 Golgi membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR associates peripherally with the cytoplasmic face of Golgi membranes; a minor location versus lysosomal/plasma-membrane sites. Reason: Secondary peripheral-membrane localization.
GO:0000822 inositol hexakisphosphate binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: InsP6 is a structural cofactor reported to stabilize the mTOR kinase domain; a structural-ligand feature rather than the catalytic activity. Reason: Structural cofactor binding; non-core.
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO GO_REF:0000119	REMOVE	Summary: mTOR is a cytoplasmic Ser/Thr kinase, not a sequence-specific DNA-binding protein; it regulates Pol III indirectly via MAF1, so direct promoter DNA binding is an erroneous electronic inference. Reason: IEA/ISO electronic mis-assignment; mTOR does not directly bind promoter DNA.
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO GO_REF:0000119	REMOVE	Summary: mTOR does not bind Pol III promoter DNA directly; its effect on Pol III is via MAF1 phosphorylation, making this DNA-binding MF an electronic error. Reason: IEA/ISO electronic mis-assignment inconsistent with a kinase.
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO GO_REF:0000119	REMOVE	Summary: Sequence-specific promoter DNA binding is not a function of the mTOR kinase; Pol III control is indirect via MAF1, so this is an erroneous propagation. Reason: IEA/ISO electronic mis-assignment inconsistent with a kinase.
GO:0001156 TFIIIC-class transcription factor complex binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reflects mTOR's engagement with the Pol III transcription machinery to control tRNA gene transcription; an interaction supporting ribosome biogenesis. Reason: Interaction supporting Pol III/ribosome biogenesis output.
GO:0001558 regulation of cell growth	ISO GO_REF:0000119	ACCEPT	Summary: mTOR sets cell-growth rate by gating protein/lipid/nucleotide synthesis through mTORC1, making it a central regulator of cell growth. Reason: Core mTORC1 output. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0001933 negative regulation of protein phosphorylation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR can lower phosphorylation of some targets (e.g. via GRB10/IRS feedback dampening insulin signaling); a downstream regulatory effect. Reason: Indirect feedback effect downstream of core mTOR signaling.
GO:0001938 positive regulation of endothelial cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR promotes endothelial proliferation in angiogenesis through growth/translation; a downstream vascular phenotype. Reason: Downstream proliferative effect (vascular).
GO:0004672 protein kinase activity	ISO GO_REF:0000119	MODIFY	Summary: mTOR is specifically a serine/threonine protein kinase; the generic 'protein kinase activity' parent should be replaced by the specific Ser/Thr child term. Reason: Generic parent where the specific Ser/Thr kinase child (GO:0004674) is the correct MF. Proposed replacements: protein serine/threonine kinase activity
GO:0004674 protein serine/threonine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	ISO GO_REF:0000096	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004713 protein tyrosine kinase activity	ISO GO_REF:0000119	REMOVE	Summary: mTOR is a Ser/Thr (PIKK-family) kinase; the tyrosine-kinase EC 2.7.10.2 activity is only an unproven by-similarity inference and is not an established function of mouse mTOR. Reason: IEA/ISO/ISS by-similarity only; contradicted by mTOR's Ser/Thr (PIKK) catalytic identity.
GO:0005635 nuclear envelope	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Nuclear-envelope association (e.g. via PLPP7/NET39) consistent with mTOR's nucleocytoplasmic shuttling. Reason: Secondary localization tied to nuclear interactions.
GO:0005737 cytoplasm	ISO GO_REF:0000119	ACCEPT	Summary: mTOR is a cytoplasmic kinase that shuttles among lysosomal, ER and plasma-membrane surfaces and the cytosol/nucleus; cytoplasmic localization is experimentally established. Reason: Supported localization (EXP/ISS); mTOR carries out its kinase function in the cytoplasm. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005741 mitochondrial outer membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR has been localized to the mitochondrial outer membrane and senses osmotic stress via mitochondrial dysfunction; a peripheral secondary location. Reason: Secondary localization (EXP) linked to stress sensing.
GO:0005764 lysosome	ISO GO_REF:0000119	MODIFY	Summary: mTOR acts at the lysosomal membrane (cytoplasmic face), not in the lysosomal lumen; the membrane component is the precise localization. Reason: Over-general; lysosomal membrane (GO:0005765) is the specific compartment for mTORC1. Proposed replacements: lysosomal membrane Supporting Evidence: UniProt:Q9JLN9 Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
GO:0005765 lysosomal membrane	ISO GO_REF:0000119	ACCEPT	Summary: mTORC1 is recruited to and activated on the cytosolic face of the lysosomal membrane by Rag-Ragulator and Rheb, the principal site where mTOR integrates nutrient and growth-factor signals. Reason: Core localization for mTORC1 activation (UniProt: lysosome membrane, peripheral, cytoplasmic side). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005783 endoplasmic reticulum	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 is active at the ER membrane; ER localization is a genuine but secondary site relative to the lysosomal mTORC1 hub. Reason: Secondary localization (mTORC2 at ER).
GO:0005789 endoplasmic reticulum membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 signals at the cytoplasmic face of the ER membrane; a real secondary location for mTOR complexes. Reason: Secondary membrane site for mTORC2.
GO:0005794 Golgi apparatus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reported Golgi-membrane pool of mTOR (peripheral, cytoplasmic side); a secondary location relative to the lysosomal site of mTORC1 activation. Reason: Secondary localization by similarity.
GO:0005829 cytosol	ISO GO_REF:0000119	ACCEPT	Summary: Soluble cytosolic pool of mTOR/mTOR complexes consistent with its peripheral-membrane association and shuttling behavior. Reason: Supported localization (IDA) for cytoplasmic mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005886 plasma membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 is active at the plasma membrane where it phosphorylates AKT/PKC; a genuine secondary location for mTOR. Reason: mTORC2 plasma-membrane site; secondary to lysosomal mTORC1.
GO:0005979 regulation of glycogen biosynthetic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Via AKT/GSK3 downstream of mTORC2, mTOR signaling modulates glycogen synthesis; an indirect metabolic effect. Reason: Indirect downstream metabolic regulation.
GO:0006109 regulation of carbohydrate metabolic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR shapes carbohydrate handling through AKT-dependent glucose metabolism and glycolytic gene programs; a broad downstream metabolic role. Reason: Downstream metabolic regulation via AKT/mTORC1.
GO:0006468 protein phosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: mTOR catalyzes transfer of phosphate to its protein substrates within mTORC1 and mTORC2, the molecular event underlying all of its signaling outputs. Reason: Core catalytic process for a protein kinase; ISO but biologically definitive for mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0007616 long-term memory	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1-dependent protein synthesis is required for long-term memory consolidation; a downstream cognitive phenotype. Reason: Downstream cognitive output of mTOR translation control.
GO:0008361 regulation of cell size	ISO GO_REF:0000119	ACCEPT	Summary: Through mTORC1-driven biosynthesis, mTOR controls attainment of cell size; loss of mTOR reduces cell size. Reason: Core; cell size is a direct readout of mTORC1 anabolic activity. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0008542 visual learning	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR-dependent synaptic plasticity underlies visual learning; a downstream behavioral phenotype. Reason: Downstream behavioral output of mTOR.
GO:0009267 cellular response to starvation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Starvation suppresses mTORC1, de-repressing autophagy; mTOR is the switch responding to nutrient deprivation. Reason: Upstream starvation input gating mTORC1.
GO:0010507 negative regulation of autophagy	ISO GO_REF:0000096	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0010507 negative regulation of autophagy	ISO GO_REF:0000119	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0010718 positive regulation of epithelial to mesenchymal transition	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR signaling (notably mTORC2) can promote EMT during development and cancer; a downstream cell-fate/motility effect. Reason: Downstream EMT-promoting effect of mTOR.
GO:0010976 positive regulation of neuron projection development	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1/mTORC2 promote axon/dendrite outgrowth through translation and cytoskeletal regulation; a downstream neuronal output. Reason: Downstream neurite-growth effect of mTOR.
GO:0012505 endomembrane system	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Broad endomembrane localization reflecting mTOR's peripheral association with lysosomal/ER/Golgi membranes. Reason: General localization subsumed by specific membrane terms.
GO:0014042 positive regulation of neuron maturation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR signaling promotes neuronal maturation via translational and growth control; a downstream developmental role. Reason: Downstream neurodevelopmental effect of mTOR.
GO:0014736 negative regulation of muscle atrophy	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Active mTORC1 opposes muscle atrophy by sustaining protein synthesis and suppressing autophagy/proteolysis. Reason: Downstream anti-atrophy effect of mTORC1.
GO:0016020 membrane	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Generic membrane association consistent with mTOR being a peripheral membrane protein on several organelles. Reason: Generic CC subsumed by specific membrane terms.
GO:0019901 protein kinase binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR binds kinase substrates/regulators (e.g. AKT, S6K, ULK1); informative as interaction context but secondary to its own kinase activity. Reason: Partner-binding adjunct to mTOR's catalytic role.
GO:0019904 protein domain specific binding	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR engages partner domains (e.g. FRB-FKBP12/rapamycin, RICTOR/RAPTOR interfaces); contextually useful but not the core function. Reason: Interaction detail secondary to core kinase/scaffold role.
GO:0021510 spinal cord development	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR-dependent growth and patterning contribute to spinal cord development; a downstream developmental phenotype. Reason: Downstream developmental role of mTOR.
GO:0030425 dendrite	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Dendritic localization of mTOR supports local translation underlying synaptic plasticity; a neuron-specific secondary site. Reason: Neuronal localization linked to local translation.
GO:0031397 negative regulation of protein ubiquitination	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR phosphorylation can shield substrates from ubiquitination (e.g. AMBRA1-ULK1 axis); a downstream regulatory effect. Reason: Downstream effect on substrate ubiquitination.
GO:0031667 response to nutrient levels	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR responds to organismal/cellular nutrient levels to coordinate growth and metabolism via mTORC1. Reason: Upstream nutrient input to mTORC1.
GO:0031669 cellular response to nutrient levels	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Nutrient abundance dictates mTORC1 lysosomal recruitment and activity; mTOR is the effector translating nutrient state into growth decisions. Reason: Upstream nutrient input to mTORC1.
GO:0031670 cellular response to nutrient	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 integrates general nutrient availability to switch between anabolism and catabolism; mTOR is the central responder. Reason: Upstream nutrient input gating mTORC1.
GO:0031929 TOR signaling	ISO GO_REF:0000119	ACCEPT	Summary: mTOR is the namesake kinase of TOR signaling, transducing nutrient/growth-factor inputs into control of growth, translation and autophagy via mTORC1 and mTORC2. Reason: Core pathway directly executed by mTOR (IMP/IGI). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	ISO GO_REF:0000096	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	ISO GO_REF:0000119	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	ISO GO_REF:0000119	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031998 regulation of fatty acid beta-oxidation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1 suppresses fatty-acid oxidation when promoting anabolism (e.g. via PPAR/PGC-1 control); a downstream metabolic switch. Reason: Downstream metabolic regulation of mTORC1.
GO:0032095 regulation of response to food	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Hypothalamic mTOR signaling links nutrient/energy status to feeding responses; a downstream physiological role. Reason: Downstream physiological response of nutrient-sensing mTOR.
GO:0032869 cellular response to insulin stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Insulin activates mTORC1/mTORC2 through PI3K-AKT-TSC-Rheb; mTOR is the central effector of the insulin growth-factor response. Reason: Upstream growth-factor input to mTOR.
GO:0032956 regulation of actin cytoskeleton organization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 regulates the actin cytoskeleton through PKC and Rho/Rac GTPases; a characteristic downstream output of mTOR's mTORC2 activity. Reason: Downstream mTORC2 cytoskeletal output.
GO:0032991 protein-containing complex	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Generic 'part of a protein complex' statement; mTOR's specific TORC1/TORC2 complex memberships are the informative annotations. Reason: Generic CC subsumed by TORC1/TORC2 complex terms.
GO:0034198 cellular response to amino acid starvation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 is inactivated upon amino-acid withdrawal (loss of Rag-Ragulator lysosomal recruitment); mTOR is the sensor-effector responding to this input. Reason: Upstream nutrient input gating core mTORC1 activity.
GO:0035176 social behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR pathway dysregulation alters social behavior (relevant to autism-spectrum models); a downstream behavioral phenotype. Reason: Downstream behavioral phenotype of mTOR.
GO:0038202 TORC1 signaling	ISO GO_REF:0000119	ACCEPT	Summary: mTORC1 signaling—phosphorylation of S6K1, 4E-BP1 and ULK1 to drive translation/growth and suppress autophagy—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC1 signaling. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	ISO GO_REF:0000119	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0042220 response to cocaine	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR-dependent synaptic plasticity mediates neuronal responses to cocaine; a downstream pharmacological/behavioral phenotype. Reason: Downstream behavioral response via mTOR plasticity.
GO:0042802 identical protein binding	ISO GO_REF:0000119	MARK AS OVER ANNOTATED	Summary: Generic self-association term; mTOR's functional dimerization is better captured by the TORC1/TORC2 complex annotations. Reason: Uninformative generic MF.
GO:0043022 ribosome binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 associates with ribosomes to cotranslationally phosphorylate nascent AKT, and mTORC1 couples to translation; a functionally relevant but ancillary interaction. Reason: Supports cotranslational substrate phosphorylation; secondary to core kinase role.
GO:0043025 neuronal cell body	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Somatic localization of mTOR in neurons consistent with its role in neuronal growth and translation. Reason: Neuron-specific secondary localization.
GO:0043200 response to amino acid	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Amino-acid availability is a principal cue activating mTORC1; mTOR senses this through the lysosomal Rag machinery. Reason: Upstream nutrient cue for mTORC1.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000119	ACCEPT	Summary: As the mTORC2 kinase, mTOR phosphorylates AKT (PKB) Ser473, a defining step of PI3K-AKT signal transduction directly executed by mTOR. Reason: Core; mTORC2 is the AKT Ser473 kinase linking PI3K to AKT activation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0043525 positive regulation of neuron apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: In some neuronal contexts mTOR signaling promotes apoptosis; a context-dependent downstream survival effect. Reason: Context-dependent downstream neuronal effect.
GO:0043610 regulation of carbohydrate utilization	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR/AKT signaling tunes cellular glucose utilization in response to growth-factor and nutrient state; a downstream metabolic effect. Reason: Downstream metabolic effect of mTOR signaling.
GO:0045335 phagocytic vesicle	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR localizes to phagosomes, relevant to phagosome maturation and innate-immune signaling; a peripheral compartment. Reason: Secondary vesicular localization.
GO:0045429 positive regulation of nitric oxide biosynthetic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR/AKT signaling can promote eNOS-dependent NO production in endothelium; an indirect downstream metabolic effect. Reason: Indirect downstream effect of mTOR-AKT signaling.
GO:0045727 positive regulation of translation	ISO GO_REF:0000096	ACCEPT	Summary: mTORC1 promotes cap-dependent translation by phosphorylating 4E-BP1 (releasing eIF4E) and activating S6K1/2, a core anabolic output of mTOR. Reason: Core; mTORC1 directly drives translation via 4E-BP1/S6K. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0045727 positive regulation of translation	ISO GO_REF:0000119	ACCEPT	Summary: mTORC1 promotes cap-dependent translation by phosphorylating 4E-BP1 (releasing eIF4E) and activating S6K1/2, a core anabolic output of mTOR. Reason: Core; mTORC1 directly drives translation via 4E-BP1/S6K. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0045945 positive regulation of transcription by RNA polymerase III	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 activates Pol III transcription by phosphorylating/inhibiting the repressor MAF1, boosting tRNA/5S rRNA synthesis; downstream of mTOR. Reason: Downstream of mTORC1 (MAF1 phosphorylation).
GO:0045948 positive regulation of translational initiation	ISO GO_REF:0000119	ACCEPT	Summary: By phosphorylating 4E-BP1 mTORC1 frees eIF4E and stimulates assembly of the cap-binding initiation complex, directly promoting translational initiation. Reason: Core; 4E-BP1 phosphorylation by mTORC1 controls initiation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0046777 protein autophosphorylation	ISO GO_REF:0000096	ACCEPT	Summary: mTOR autophosphorylates (e.g. Ser2481) when assembled in mTORC1 or mTORC2, a hallmark of the active kinase used to report complex integrity. Reason: Core intrinsic kinase activity; documented mTOR autophosphorylation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0046889 positive regulation of lipid biosynthetic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR drives lipogenesis through SREBP1 and LPIN1 (mTORC1) and lipid synthesis programs (mTORC2); a major anabolic output downstream of mTOR. Reason: Downstream lipogenic program of mTOR signaling.
GO:0048255 mRNA stabilization	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC2 phosphorylation of IGF2BP1/IMP1 promotes target mRNA stability/translation; a downstream RNA-regulatory effect of mTOR. Reason: Downstream effect via mTORC2 substrate phosphorylation.
GO:0048661 positive regulation of smooth muscle cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR drives smooth-muscle proliferation (e.g. vascular remodeling); a downstream proliferative phenotype. Reason: Downstream proliferative effect.
GO:0048714 positive regulation of oligodendrocyte differentiation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR signaling promotes oligodendrocyte differentiation and myelination programs; a downstream CNS differentiation role. Reason: Downstream CNS differentiation effect (IMP).
GO:0050769 positive regulation of neurogenesis	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR-driven growth/translation supports neural progenitor proliferation and neurogenesis; a downstream developmental output. Reason: Downstream neurodevelopmental effect of mTOR.
GO:0051219 phosphoprotein binding	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR/its complexes recognize phosphorylated regulators (e.g. via SIN1/RPTOR); an interaction feature, not the core activity. Reason: Partner recognition adjunct to core function.
GO:0051549 positive regulation of keratinocyte migration	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR signaling promotes keratinocyte migration in wound healing through its cytoskeletal/growth outputs. Reason: Downstream motility/wound-healing effect.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000096	ACCEPT	Summary: mTORC2-mediated AKT hydrophobic-motif phosphorylation positively regulates PI3K-AKT signaling, a direct proximal output of mTOR kinase activity. Reason: Core; mTORC2 directly activates AKT via Ser473 phosphorylation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0060135 maternal process involved in female pregnancy	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR nutrient sensing in maternal/placental tissues supports pregnancy-associated growth processes; a downstream physiological role. Reason: Downstream physiological role of mTOR sensing.
GO:0060252 positive regulation of glial cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR's growth/proliferative outputs drive glial cell proliferation; a downstream CNS phenotype. Reason: Downstream proliferative effect in glia.
GO:0060999 positive regulation of dendritic spine development	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR-dependent local translation supports dendritic-spine formation/maturation underlying synaptic plasticity. Reason: Downstream synaptic-plasticity effect of mTOR.
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1-driven growth contributes to cardiomyocyte hypertrophic growth during heart development; a tissue-specific instance of mTOR's growth output. Reason: Tissue-specific instance of mTOR growth control.
GO:0061431 cellular response to methionine	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Methionine/SAM availability signals to mTORC1 (e.g. via SAMTOR); mTOR responds to set anabolic activity. Reason: Specific amino-acid input to mTORC1.
GO:0062027 positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR phosphorylation can promote SCF-mediated substrate degradation (IRS1 turnover), feeding back on insulin signaling. Reason: Downstream proteostatic feedback of mTOR signaling.
GO:0071230 cellular response to amino acid stimulus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Amino acids activate mTORC1 via Rag GTPases/Ragulator and lysosomal recruitment; mTOR responds to this stimulus to drive growth. Reason: Upstream nutrient input to mTORC1.
GO:0071233 cellular response to L-leucine	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Leucine is a key amino acid activating mTORC1 (via Sestrin2/leucyl-tRNA pathways and Rag GTPases); mTOR is the responding effector. Reason: Specific amino-acid input to mTORC1.
GO:0090335 regulation of brown fat cell differentiation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR (notably an FLCN-dependent non-canonical mTORC1 axis) regulates adipose browning/brown-fat differentiation; a tissue-level downstream role. Reason: Downstream tissue differentiation controlled by mTOR.
GO:0098978 glutamatergic synapse	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Synaptic mTOR pool supports activity-dependent local translation at glutamatergic synapses; a specialized neuronal localization. Reason: Neuronal-synapse localization.
GO:0099524 postsynaptic cytosol	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Postsynaptic cytosolic mTOR participates in local translational control of synaptic plasticity. Reason: Neuronal-synapse localization.
GO:0099547 regulation of translation at synapse, modulating synaptic transmission	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1-dependent local dendritic translation supports synaptic plasticity; a neuron-specific downstream output of mTOR. Reason: Downstream neuronal translation control by mTOR.
GO:0106310 protein serine kinase activity	ISO GO_REF:0000096	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	ISO GO_REF:0000119	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:1900181 negative regulation of protein localization to nucleus	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to retain them in the cytosol, preventing their nuclear entry; a specific mechanistic downstream effect. Reason: Downstream MiT/TFE cytosolic-retention effect of mTORC1.
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 promotes rRNA synthesis (Pol I) to support ribosome biogenesis, a downstream anabolic output of mTOR. Reason: Downstream ribosome-biogenesis output of mTORC1.
GO:1903691 positive regulation of wound healing, spreading of epidermal cells	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR-dependent migration/proliferation of epidermal cells supports wound re-epithelialization; a downstream tissue process. Reason: Downstream wound-healing process.
GO:1904000 positive regulation of eating behavior	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Hypothalamic mTORC1 activity modulates appetite/food intake; a downstream behavioral output of mTOR nutrient sensing. Reason: Downstream behavioral effect of mTOR signaling.
GO:1904037 positive regulation of epithelial cell apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: In some contexts mTOR signaling promotes epithelial apoptosis; a context-dependent downstream survival effect. Reason: Context-dependent downstream apoptotic effect.
GO:1904056 positive regulation of cholangiocyte proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR signaling promotes cholangiocyte (bile-duct epithelial) proliferation; a downstream hepatic phenotype. Reason: Downstream proliferative effect (liver).
GO:1904193 negative regulation of cholangiocyte apoptotic process	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR/AKT survival signaling suppresses cholangiocyte apoptosis; a downstream pro-survival phenotype. Reason: Downstream pro-survival effect of mTOR.
GO:1904197 positive regulation of granulosa cell proliferation	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR supports ovarian granulosa-cell proliferation during follicle growth; a downstream tissue phenotype. Reason: Downstream proliferative effect (ovary).
GO:1904206 positive regulation of skeletal muscle hypertrophy	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTORC1 drives skeletal-muscle hypertrophy by stimulating protein synthesis; a tissue-specific instance of mTOR's growth output. Reason: Downstream muscle-growth output of mTORC1.
GO:1904213 negative regulation of iodide transmembrane transport	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: mTOR signaling can suppress thyroid iodide uptake (NIS regulation); a downstream tissue-specific physiological effect. Reason: Downstream physiological effect of mTOR.
GO:1905671 regulation of lysosome organization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Via TFEB/TFE3 phosphorylation mTORC1 regulates lysosomal gene programs and organelle homeostasis. Reason: Downstream MiT/TFE-mediated effect of mTORC1.
GO:1905672 negative regulation of lysosome organization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to keep them cytosolic, suppressing lysosomal/autophagy gene expression and biogenesis. Reason: Downstream MiT/TFE inhibition by mTORC1.
GO:1990253 cellular response to leucine starvation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Leucine withdrawal inactivates mTORC1; mTOR is the kinase whose activity drops in response. Reason: Upstream nutrient input to mTORC1.
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR-directed phosphorylation can mark substrates for ubiquitin-dependent degradation; a downstream proteostatic effect. Reason: Downstream proteostatic effect of mTOR signaling.
GO:2000774 positive regulation of cellular senescence	ISO GO_REF:0000096	KEEP AS NON CORE	Summary: Hyperactive mTOR drives geroconversion/cellular senescence (the basis of rapamycin's anti-aging effect); a downstream phenotype. Reason: Downstream aging-related effect of mTOR.
GO:2000785 regulation of autophagosome assembly	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 negatively regulates autophagosome assembly via ULK1; a specific facet of its autophagy-suppressive output. Reason: Downstream autophagy regulation by mTORC1.
GO:0000822 inositol hexakisphosphate binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: InsP6 is a structural cofactor reported to stabilize the mTOR kinase domain; a structural-ligand feature rather than the catalytic activity. Reason: Structural cofactor binding; non-core.
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding	IEA GO_REF:0000107	REMOVE	Summary: mTOR is a cytoplasmic Ser/Thr kinase, not a sequence-specific DNA-binding protein; it regulates Pol III indirectly via MAF1, so direct promoter DNA binding is an erroneous electronic inference. Reason: IEA/ISO electronic mis-assignment; mTOR does not directly bind promoter DNA.
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding	IEA GO_REF:0000107	REMOVE	Summary: mTOR does not bind Pol III promoter DNA directly; its effect on Pol III is via MAF1 phosphorylation, making this DNA-binding MF an electronic error. Reason: IEA/ISO electronic mis-assignment inconsistent with a kinase.
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding	IEA GO_REF:0000107	REMOVE	Summary: Sequence-specific promoter DNA binding is not a function of the mTOR kinase; Pol III control is indirect via MAF1, so this is an erroneous propagation. Reason: IEA/ISO electronic mis-assignment inconsistent with a kinase.
GO:0001156 TFIIIC-class transcription factor complex binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reflects mTOR's engagement with the Pol III transcription machinery to control tRNA gene transcription; an interaction supporting ribosome biogenesis. Reason: Interaction supporting Pol III/ribosome biogenesis output.
GO:0001558 regulation of cell growth	IEA GO_REF:0000107	ACCEPT	Summary: mTOR sets cell-growth rate by gating protein/lipid/nucleotide synthesis through mTORC1, making it a central regulator of cell growth. Reason: Core mTORC1 output. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004672 protein kinase activity	IEA GO_REF:0000107	MODIFY	Summary: mTOR is specifically a serine/threonine protein kinase; the generic 'protein kinase activity' parent should be replaced by the specific Ser/Thr child term. Reason: Generic parent where the specific Ser/Thr kinase child (GO:0004674) is the correct MF. Proposed replacements: protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity	IEA GO_REF:0000120	REMOVE	Summary: mTOR is a Ser/Thr (PIKK-family) kinase; the tyrosine-kinase EC 2.7.10.2 activity is only an unproven by-similarity inference and is not an established function of mouse mTOR. Reason: IEA/ISO/ISS by-similarity only; contradicted by mTOR's Ser/Thr (PIKK) catalytic identity.
GO:0005635 nuclear envelope	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Nuclear-envelope association (e.g. via PLPP7/NET39) consistent with mTOR's nucleocytoplasmic shuttling. Reason: Secondary localization tied to nuclear interactions.
GO:0005764 lysosome	IEA GO_REF:0000107	MODIFY	Summary: mTOR acts at the lysosomal membrane (cytoplasmic face), not in the lysosomal lumen; the membrane component is the precise localization. Reason: Over-general; lysosomal membrane (GO:0005765) is the specific compartment for mTORC1. Proposed replacements: lysosomal membrane Supporting Evidence: UniProt:Q9JLN9 Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
GO:0005783 endoplasmic reticulum	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC2 is active at the ER membrane; ER localization is a genuine but secondary site relative to the lysosomal mTORC1 hub. Reason: Secondary localization (mTORC2 at ER).
GO:0005794 Golgi apparatus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Reported Golgi-membrane pool of mTOR (peripheral, cytoplasmic side); a secondary location relative to the lysosomal site of mTORC1 activation. Reason: Secondary localization by similarity.
GO:0005829 cytosol	IEA GO_REF:0000120	ACCEPT	Summary: Soluble cytosolic pool of mTOR/mTOR complexes consistent with its peripheral-membrane association and shuttling behavior. Reason: Supported localization (IDA) for cytoplasmic mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0008361 regulation of cell size	IEA GO_REF:0000107	ACCEPT	Summary: Through mTORC1-driven biosynthesis, mTOR controls attainment of cell size; loss of mTOR reduces cell size. Reason: Core; cell size is a direct readout of mTORC1 anabolic activity. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0009267 cellular response to starvation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Starvation suppresses mTORC1, de-repressing autophagy; mTOR is the switch responding to nutrient deprivation. Reason: Upstream starvation input gating mTORC1.
GO:0010507 negative regulation of autophagy	IEA GO_REF:0000120	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0010718 positive regulation of epithelial to mesenchymal transition	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR signaling (notably mTORC2) can promote EMT during development and cancer; a downstream cell-fate/motility effect. Reason: Downstream EMT-promoting effect of mTOR.
GO:0012505 endomembrane system	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Broad endomembrane localization reflecting mTOR's peripheral association with lysosomal/ER/Golgi membranes. Reason: General localization subsumed by specific membrane terms.
GO:0016020 membrane	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Generic membrane association consistent with mTOR being a peripheral membrane protein on several organelles. Reason: Generic CC subsumed by specific membrane terms.
GO:0031667 response to nutrient levels	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR responds to organismal/cellular nutrient levels to coordinate growth and metabolism via mTORC1. Reason: Upstream nutrient input to mTORC1.
GO:0031669 cellular response to nutrient levels	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Nutrient abundance dictates mTORC1 lysosomal recruitment and activity; mTOR is the effector translating nutrient state into growth decisions. Reason: Upstream nutrient input to mTORC1.
GO:0031670 cellular response to nutrient	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC1 integrates general nutrient availability to switch between anabolism and catabolism; mTOR is the central responder. Reason: Upstream nutrient input gating mTORC1.
GO:0031929 TOR signaling	IEA GO_REF:0000107	ACCEPT	Summary: mTOR is the namesake kinase of TOR signaling, transducing nutrient/growth-factor inputs into control of growth, translation and autophagy via mTORC1 and mTORC2. Reason: Core pathway directly executed by mTOR (IMP/IGI). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	IEA GO_REF:0000120	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IEA GO_REF:0000107	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0032869 cellular response to insulin stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Insulin activates mTORC1/mTORC2 through PI3K-AKT-TSC-Rheb; mTOR is the central effector of the insulin growth-factor response. Reason: Upstream growth-factor input to mTOR.
GO:0032956 regulation of actin cytoskeleton organization	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC2 regulates the actin cytoskeleton through PKC and Rho/Rac GTPases; a characteristic downstream output of mTOR's mTORC2 activity. Reason: Downstream mTORC2 cytoskeletal output.
GO:0034198 cellular response to amino acid starvation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC1 is inactivated upon amino-acid withdrawal (loss of Rag-Ragulator lysosomal recruitment); mTOR is the sensor-effector responding to this input. Reason: Upstream nutrient input gating core mTORC1 activity.
GO:0038202 TORC1 signaling	IEA GO_REF:0000107	ACCEPT	Summary: mTORC1 signaling—phosphorylation of S6K1, 4E-BP1 and ULK1 to drive translation/growth and suppress autophagy—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC1 signaling. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IEA GO_REF:0000107	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0042802 identical protein binding	IEA GO_REF:0000107	MARK AS OVER ANNOTATED	Summary: Generic self-association term; mTOR's functional dimerization is better captured by the TORC1/TORC2 complex annotations. Reason: Uninformative generic MF.
GO:0043022 ribosome binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC2 associates with ribosomes to cotranslationally phosphorylate nascent AKT, and mTORC1 couples to translation; a functionally relevant but ancillary interaction. Reason: Supports cotranslational substrate phosphorylation; secondary to core kinase role.
GO:0043200 response to amino acid	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Amino-acid availability is a principal cue activating mTORC1; mTOR senses this through the lysosomal Rag machinery. Reason: Upstream nutrient cue for mTORC1.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	ACCEPT	Summary: As the mTORC2 kinase, mTOR phosphorylates AKT (PKB) Ser473, a defining step of PI3K-AKT signal transduction directly executed by mTOR. Reason: Core; mTORC2 is the AKT Ser473 kinase linking PI3K to AKT activation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0045727 positive regulation of translation	IEA GO_REF:0000107	ACCEPT	Summary: mTORC1 promotes cap-dependent translation by phosphorylating 4E-BP1 (releasing eIF4E) and activating S6K1/2, a core anabolic output of mTOR. Reason: Core; mTORC1 directly drives translation via 4E-BP1/S6K. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0045945 positive regulation of transcription by RNA polymerase III	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC1 activates Pol III transcription by phosphorylating/inhibiting the repressor MAF1, boosting tRNA/5S rRNA synthesis; downstream of mTOR. Reason: Downstream of mTORC1 (MAF1 phosphorylation).
GO:0045948 positive regulation of translational initiation	IEA GO_REF:0000107	ACCEPT	Summary: By phosphorylating 4E-BP1 mTORC1 frees eIF4E and stimulates assembly of the cap-binding initiation complex, directly promoting translational initiation. Reason: Core; 4E-BP1 phosphorylation by mTORC1 controls initiation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0046889 positive regulation of lipid biosynthetic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR drives lipogenesis through SREBP1 and LPIN1 (mTORC1) and lipid synthesis programs (mTORC2); a major anabolic output downstream of mTOR. Reason: Downstream lipogenic program of mTOR signaling.
GO:0051219 phosphoprotein binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR/its complexes recognize phosphorylated regulators (e.g. via SIN1/RPTOR); an interaction feature, not the core activity. Reason: Partner recognition adjunct to core function.
GO:0051549 positive regulation of keratinocyte migration	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR signaling promotes keratinocyte migration in wound healing through its cytoskeletal/growth outputs. Reason: Downstream motility/wound-healing effect.
GO:0061431 cellular response to methionine	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Methionine/SAM availability signals to mTORC1 (e.g. via SAMTOR); mTOR responds to set anabolic activity. Reason: Specific amino-acid input to mTORC1.
GO:0062027 positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR phosphorylation can promote SCF-mediated substrate degradation (IRS1 turnover), feeding back on insulin signaling. Reason: Downstream proteostatic feedback of mTOR signaling.
GO:0071230 cellular response to amino acid stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Amino acids activate mTORC1 via Rag GTPases/Ragulator and lysosomal recruitment; mTOR responds to this stimulus to drive growth. Reason: Upstream nutrient input to mTORC1.
GO:0071233 cellular response to L-leucine	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Leucine is a key amino acid activating mTORC1 (via Sestrin2/leucyl-tRNA pathways and Rag GTPases); mTOR is the responding effector. Reason: Specific amino-acid input to mTORC1.
GO:1900181 negative regulation of protein localization to nucleus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to retain them in the cytosol, preventing their nuclear entry; a specific mechanistic downstream effect. Reason: Downstream MiT/TFE cytosolic-retention effect of mTORC1.
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC1 promotes rRNA synthesis (Pol I) to support ribosome biogenesis, a downstream anabolic output of mTOR. Reason: Downstream ribosome-biogenesis output of mTORC1.
GO:1903691 positive regulation of wound healing, spreading of epidermal cells	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTOR-dependent migration/proliferation of epidermal cells supports wound re-epithelialization; a downstream tissue process. Reason: Downstream wound-healing process.
GO:1905671 regulation of lysosome organization	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Via TFEB/TFE3 phosphorylation mTORC1 regulates lysosomal gene programs and organelle homeostasis. Reason: Downstream MiT/TFE-mediated effect of mTORC1.
GO:1905672 negative regulation of lysosome organization	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to keep them cytosolic, suppressing lysosomal/autophagy gene expression and biogenesis. Reason: Downstream MiT/TFE inhibition by mTORC1.
GO:1990253 cellular response to leucine starvation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Leucine withdrawal inactivates mTORC1; mTOR is the kinase whose activity drops in response. Reason: Upstream nutrient input to mTORC1.
GO:2000785 regulation of autophagosome assembly	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: mTORC1 negatively regulates autophagosome assembly via ULK1; a specific facet of its autophagy-suppressive output. Reason: Downstream autophagy regulation by mTORC1.
GO:0031648 protein destabilization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2 phosphorylation can target substrates (e.g. AKT, IRS1 via Fbw8) for turnover; a downstream proteostatic consequence of mTOR signaling. Reason: Downstream effect of mTOR-directed phosphorylation.
GO:0000045 autophagosome assembly	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 gates autophagosome formation by controlling ULK1/the initiation machinery; the process it regulates rather than a structure it builds. Reason: Downstream autophagy process regulated by mTORC1.
GO:0002181 cytoplasmic translation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 stimulates the cytoplasmic translation apparatus (eIF4F assembly, S6K) as a downstream anabolic output; mTOR is a regulator, not a ribosomal component. Reason: Downstream translation output of mTORC1.
GO:0006446 regulation of translational initiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 controls initiation through 4E-BP1/eIF4E and S6K; specific positive-initiation terms capture the core direction. Reason: Generic regulation covered by specific positive-initiation terms.
GO:0006511 ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR signaling influences proteasomal turnover of substrates (e.g. IRS1 via Fbw8, AKT); a downstream proteostatic consequence. Reason: Downstream effect of mTOR-directed phosphorylation on turnover.
GO:0007040 lysosome organization	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 controls lysosome biogenesis/organization through TFEB/TFE3 phosphorylation and cytosolic retention; a downstream organelle-level output. Reason: Downstream TFEB/TFE3-mediated effect of mTORC1.
GO:0008284 positive regulation of cell population proliferation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: By promoting growth and survival, mTOR signaling supports cell proliferation; a downstream proliferative output. Reason: Downstream proliferative effect of mTOR.
GO:0008286 insulin receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR operates downstream of the insulin receptor and exerts feedback (GRB10/IRS1) on it; an integral but downstream node of insulin signaling. Reason: Downstream/feedback node of insulin signaling.
GO:0010508 positive regulation of autophagy	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Atypical positive autophagy contexts (e.g. selective/non-canonical autophagy) attributed to mTOR signaling; minor relative to its dominant suppressive role. Reason: Context-specific downstream effect opposite to mTOR's main autophagy role.
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC2-driven phosphorylation routes substrates (e.g. IRS1) to SCF/Fbw8-mediated degradation; a downstream proteostatic output. Reason: Downstream proteostasis via mTORC2 phosphorylation.
GO:0045824 negative regulation of innate immune response	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR can dampen innate immune output (e.g. via metabolic/translational control); a downstream immune-regulatory effect. Reason: Downstream immune-regulatory effect.
GO:0045947 negative regulation of translational initiation	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: In some contexts mTOR-linked feedback restrains initiation (e.g. when mTORC1 is inhibited); a context-dependent downstream effect. Reason: Context-dependent downstream effect on initiation.
GO:0046627 negative regulation of insulin receptor signaling pathway	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTORC1 phosphorylates GRB10 and promotes IRS1 turnover, providing negative feedback on insulin-receptor signaling. Reason: Downstream feedback inhibition by mTORC1.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO GO_REF:0000119	ACCEPT	Summary: mTORC2-mediated AKT hydrophobic-motif phosphorylation positively regulates PI3K-AKT signaling, a direct proximal output of mTOR kinase activity. Reason: Core; mTORC2 directly activates AKT via Ser473 phosphorylation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0140367 antibacterial innate immune response	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: mTOR shapes innate antibacterial responses (autophagy/translation control in immune cells); a downstream immune role. Reason: Downstream innate-immune role of mTOR.
GO:1902554 serine/threonine protein kinase complex	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Generic parent of the mTORC1/mTORC2 kinase complexes; the specific TORC1/TORC2 complex terms are the informative annotations for mTOR. Reason: Subsumed by the specific TORC1/TORC2 complex annotations.
GO:1903940 negative regulation of TORC2 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Negative feedback on mTORC2 signaling; a regulatory nuance secondary to mTOR's core mTORC2 kinase role. Reason: Feedback aspect of mTORC2 signaling, not the core function.
GO:1904262 negative regulation of TORC1 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Captures contexts where mTOR activity (e.g. RPTOR phosphorylation) feeds back to dampen mTORC1; a regulatory facet of, rather than the core driving role of, mTOR. Reason: Feedback regulation downstream of core mTORC1 kinase activity.
GO:1904263 positive regulation of TORC1 signaling	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: Reflects mTOR autophosphorylation/assembly events that enhance mTORC1 output; ancillary to the core catalytic signaling annotation. Reason: Positive autoregulation downstream of core mTORC1 activity.
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	KEEP AS NON CORE	Summary: In other contexts mTOR signaling stabilizes substrates by limiting their ubiquitin-dependent turnover; a context-dependent proteostatic effect. Reason: Context-dependent downstream proteostatic effect.
GO:0006974 DNA damage response	NAS PMID:17041623 Stress and mTORture signaling.	KEEP AS NON CORE	Summary: mTOR (a PIKK-family kinase) intersects DNA-damage/stress signaling; a contextual role secondary to its growth-control function. Reason: Contextual PIKK-family stress role (NAS).
GO:0007010 cytoskeleton organization	NAS PMID:15268862 Rictor, a novel binding partner of mTOR, defines a rapamycin...	KEEP AS NON CORE	Summary: mTORC2 controls cytoskeletal organization via PKCα/Rho-Rac signaling; a broad downstream effect of mTOR. Reason: Downstream mTORC2 cytoskeletal output (NAS).
GO:0010507 negative regulation of autophagy	NAS PMID:28283069 mTOR Signaling in Growth, Metabolism, and Disease.	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0030307 positive regulation of cell growth	NAS PMID:22500797 mTOR signaling in growth control and disease.	ACCEPT	Summary: Integrating its translational and anabolic outputs, mTORC1 promotes increases in cell mass/size; cell growth is the canonical phenotype of mTOR activity. Reason: Core; growth promotion is the defining mTORC1 output. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0030307 positive regulation of cell growth	NAS PMID:25906254 mLST8 Promotes mTOR-Mediated Tumor Progression.	ACCEPT	Summary: Integrating its translational and anabolic outputs, mTORC1 promotes increases in cell mass/size; cell growth is the canonical phenotype of mTOR activity. Reason: Core; growth promotion is the defining mTORC1 output. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031669 cellular response to nutrient levels	NAS PMID:19299511 Specific activation of mTORC1 by Rheb G-protein in vitro inv...	KEEP AS NON CORE	Summary: Nutrient abundance dictates mTORC1 lysosomal recruitment and activity; mTOR is the effector translating nutrient state into growth decisions. Reason: Upstream nutrient input to mTORC1.
GO:0031669 cellular response to nutrient levels	NAS PMID:22500797 mTOR signaling in growth control and disease.	KEEP AS NON CORE	Summary: Nutrient abundance dictates mTORC1 lysosomal recruitment and activity; mTOR is the effector translating nutrient state into growth decisions. Reason: Upstream nutrient input to mTORC1.
GO:0043066 negative regulation of apoptotic process	NAS PMID:22500797 mTOR signaling in growth control and disease.	KEEP AS NON CORE	Summary: Through mTORC2-AKT survival signaling mTOR generally suppresses apoptosis; a downstream pro-survival output. Reason: Downstream pro-survival effect (mTORC2-AKT).
GO:0045821 positive regulation of glycolytic process	NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream...	KEEP AS NON CORE	Summary: mTORC1 boosts glycolysis (via HIF1/MYC programs) to fuel anabolic growth; a metabolic consequence of mTORC1 activity. Reason: Downstream metabolic output of mTORC1.
GO:0046889 positive regulation of lipid biosynthetic process	NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream...	KEEP AS NON CORE	Summary: mTOR drives lipogenesis through SREBP1 and LPIN1 (mTORC1) and lipid synthesis programs (mTORC2); a major anabolic output downstream of mTOR. Reason: Downstream lipogenic program of mTOR signaling.
GO:0071456 cellular response to hypoxia	NAS PMID:17041623 Stress and mTORture signaling.	KEEP AS NON CORE	Summary: Hypoxia inhibits mTORC1 (REDD1/TSC-dependent) and triggers mTOR nuclear accumulation; mTOR is the responding effector. Reason: Upstream stress input gating mTORC1 (IDA/NAS).
GO:0071470 cellular response to osmotic stress	NAS PMID:17041623 Stress and mTORture signaling.	KEEP AS NON CORE	Summary: mTOR senses osmotic stress via mitochondrial dysfunction, altering its activity; an upstream stress input. Reason: Upstream stress response of mTOR.
GO:1905857 positive regulation of pentose-phosphate shunt	NAS PMID:20670887 Activation of a metabolic gene regulatory network downstream...	KEEP AS NON CORE	Summary: mTORC1 promotes flux through the pentose phosphate pathway to supply nucleotide precursors, a delayed metabolic output of mTORC1. Reason: Downstream metabolic effect of mTORC1.
GO:0000139 Golgi membrane	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTOR associates peripherally with the cytoplasmic face of Golgi membranes; a minor location versus lysosomal/plasma-membrane sites. Reason: Secondary peripheral-membrane localization.
GO:0004713 protein tyrosine kinase activity	ISS GO_REF:0000024	REMOVE	Summary: mTOR is a Ser/Thr (PIKK-family) kinase; the tyrosine-kinase EC 2.7.10.2 activity is only an unproven by-similarity inference and is not an established function of mouse mTOR. Reason: IEA/ISO/ISS by-similarity only; contradicted by mTOR's Ser/Thr (PIKK) catalytic identity.
GO:0005634 nucleus	EXP PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	KEEP AS NON CORE	Summary: mTOR shuttles to the nucleus and accumulates there under hypoxia; a regulated secondary localization beyond its cytoplasmic membrane sites. Reason: Regulated nuclear pool (EXP/IDA); secondary location.
GO:0005737 cytoplasm	EXP PMID:11930000 FKBP12-rapamycin-associated protein associates with mitochon...	ACCEPT	Summary: mTOR is a cytoplasmic kinase that shuttles among lysosomal, ER and plasma-membrane surfaces and the cytosol/nucleus; cytoplasmic localization is experimentally established. Reason: Supported localization (EXP/ISS); mTOR carries out its kinase function in the cytoplasm. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005737 cytoplasm	EXP PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	ACCEPT	Summary: mTOR is a cytoplasmic kinase that shuttles among lysosomal, ER and plasma-membrane surfaces and the cytosol/nucleus; cytoplasmic localization is experimentally established. Reason: Supported localization (EXP/ISS); mTOR carries out its kinase function in the cytoplasm. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005741 mitochondrial outer membrane	EXP PMID:11930000 FKBP12-rapamycin-associated protein associates with mitochon...	KEEP AS NON CORE	Summary: mTOR has been localized to the mitochondrial outer membrane and senses osmotic stress via mitochondrial dysfunction; a peripheral secondary location. Reason: Secondary localization (EXP) linked to stress sensing.
GO:0005765 lysosomal membrane	ISS GO_REF:0000024	ACCEPT	Summary: mTORC1 is recruited to and activated on the cytosolic face of the lysosomal membrane by Rag-Ragulator and Rheb, the principal site where mTOR integrates nutrient and growth-factor signals. Reason: Core localization for mTORC1 activation (UniProt: lysosome membrane, peripheral, cytoplasmic side). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005789 endoplasmic reticulum membrane	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTORC2 signals at the cytoplasmic face of the ER membrane; a real secondary location for mTOR complexes. Reason: Secondary membrane site for mTORC2.
GO:0005886 plasma membrane	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTORC2 is active at the plasma membrane where it phosphorylates AKT/PKC; a genuine secondary location for mTOR. Reason: mTORC2 plasma-membrane site; secondary to lysosomal mTORC1.
GO:0106310 protein serine kinase activity	EXP PMID:11792863 Insulin-stimulated phosphorylation of lipin mediated by the ...	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	EXP PMID:18566587 Essential function of TORC2 in PKC and Akt turn motif phosph...	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	EXP PMID:21321111 mTOR complex 2 targets Akt for proteasomal degradation via p...	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	EXP PMID:27913603 The tumor suppressor FLCN mediates an alternate mTOR pathway...	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0106310 protein serine kinase activity	EXP PMID:31548312 Serine 474 phosphorylation is essential for maximal Akt2 kin...	ACCEPT	Summary: Captures mTOR phosphorylation of serine residues (e.g. AKT Ser473, 4E-BP1 serines), a component of its EC 2.7.11.1 serine/threonine kinase activity. Reason: Core MF consistent with experimental serine-phosphorylation of mTOR substrates. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0044325 transmembrane transporter binding	IPI PMID:27782176 Functional kinomics establishes a critical node of volume-se...	KEEP AS NON CORE	Summary: mTOR interacts with lysosomal transporters/channels (e.g. TPCN1/2, SLC38A9-type recruiters) relevant to nutrient sensing and recruitment. Reason: IPI interaction linked to lysosomal recruitment; non-core.
GO:0009615 response to virus	IDA PMID:36735752 Picornavirus infection enhances aspartate by the SLC38A8 tra...	KEEP AS NON CORE	Summary: mTOR signaling is engaged during antiviral responses (translational control, innate immunity); a downstream physiological role. Reason: Downstream innate-immune/translational role.
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTOR-directed phosphorylation can mark substrates for ubiquitin-dependent degradation; a downstream proteostatic effect. Reason: Downstream proteostatic effect of mTOR signaling.
GO:0004674 protein serine/threonine kinase activity	ISO PMID:15185396 Loss of tuberous sclerosis complex 1 (Tsc1) expression resul...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:1905671 regulation of lysosome organization	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Via TFEB/TFE3 phosphorylation mTORC1 regulates lysosomal gene programs and organelle homeostasis. Reason: Downstream MiT/TFE-mediated effect of mTORC1.
GO:0046889 positive regulation of lipid biosynthetic process	IDA PMID:29232555 mTORC2 Promotes Tumorigenesis via Lipid Synthesis.	KEEP AS NON CORE	Summary: mTOR drives lipogenesis through SREBP1 and LPIN1 (mTORC1) and lipid synthesis programs (mTORC2); a major anabolic output downstream of mTOR. Reason: Downstream lipogenic program of mTOR signaling.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:34245780 The innate immune kinase TBK1 directly increases mTORC2 acti...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:34245780 The innate immune kinase TBK1 directly increases mTORC2 acti...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:23142081 mTOR complex 2 regulates proper turnover of insulin receptor...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:23388827 mTOR complex 2 phosphorylates IMP1 cotranslationally to prom...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IDA PMID:23142081 mTOR complex 2 regulates proper turnover of insulin receptor...	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IDA PMID:23388827 mTOR complex 2 phosphorylates IMP1 cotranslationally to prom...	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0032869 cellular response to insulin stimulus	IDA PMID:23142081 mTOR complex 2 regulates proper turnover of insulin receptor...	KEEP AS NON CORE	Summary: Insulin activates mTORC1/mTORC2 through PI3K-AKT-TSC-Rheb; mTOR is the central effector of the insulin growth-factor response. Reason: Upstream growth-factor input to mTOR.
GO:0038203 TORC2 signaling	IDA PMID:23142081 mTOR complex 2 regulates proper turnover of insulin receptor...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:23388827 mTOR complex 2 phosphorylates IMP1 cotranslationally to prom...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:29232555 mTORC2 Promotes Tumorigenesis via Lipid Synthesis.	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005783 endoplasmic reticulum	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTORC2 is active at the ER membrane; ER localization is a genuine but secondary site relative to the lysosomal mTORC1 hub. Reason: Secondary localization (mTORC2 at ER).
GO:0004674 protein serine/threonine kinase activity	IDA PMID:18566586 The mammalian target of rapamycin complex 2 controls folding...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:18566587 Essential function of TORC2 in PKC and Akt turn motif phosph...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:21321111 mTOR complex 2 targets Akt for proteasomal degradation via p...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:24670654 Cell-cycle-regulated activation of Akt kinase by phosphoryla...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:31548312 Serine 474 phosphorylation is essential for maximal Akt2 kin...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:33850054 mTORC2 controls the activity of PKC and Akt by phosphorylati...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IDA PMID:24670654 Cell-cycle-regulated activation of Akt kinase by phosphoryla...	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	IDA PMID:33850054 mTORC2 controls the activity of PKC and Akt by phosphorylati...	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:18566586 The mammalian target of rapamycin complex 2 controls folding...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:18566587 Essential function of TORC2 in PKC and Akt turn motif phosph...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:21321111 mTOR complex 2 targets Akt for proteasomal degradation via p...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:24670654 Cell-cycle-regulated activation of Akt kinase by phosphoryla...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:31548312 Serine 474 phosphorylation is essential for maximal Akt2 kin...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	IDA PMID:33850054 mTORC2 controls the activity of PKC and Akt by phosphorylati...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA PMID:18566586 The mammalian target of rapamycin complex 2 controls folding...	ACCEPT	Summary: mTOR regulates PI3K-AKT signaling both as the mTORC2 AKT-kinase and via mTORC1 feedback (GRB10/IRS), placing it as a direct regulator of this pathway. Reason: Core; mTOR directly sets AKT activity through mTORC2 and mTORC1 feedback. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA PMID:21321111 mTOR complex 2 targets Akt for proteasomal degradation via p...	ACCEPT	Summary: mTOR regulates PI3K-AKT signaling both as the mTORC2 AKT-kinase and via mTORC1 feedback (GRB10/IRS), placing it as a direct regulator of this pathway. Reason: Core; mTOR directly sets AKT activity through mTORC2 and mTORC1 feedback. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA PMID:31548312 Serine 474 phosphorylation is essential for maximal Akt2 kin...	ACCEPT	Summary: mTOR regulates PI3K-AKT signaling both as the mTORC2 AKT-kinase and via mTORC1 feedback (GRB10/IRS), placing it as a direct regulator of this pathway. Reason: Core; mTOR directly sets AKT activity through mTORC2 and mTORC1 feedback. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0000822 inositol hexakisphosphate binding	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: InsP6 is a structural cofactor reported to stabilize the mTOR kinase domain; a structural-ligand feature rather than the catalytic activity. Reason: Structural cofactor binding; non-core.
GO:0031932 TORC2 complex	ISS GO_REF:0000024	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038203 TORC2 signaling	ISS GO_REF:0000024	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038202 TORC1 signaling	ISS GO_REF:0000024	ACCEPT	Summary: mTORC1 signaling—phosphorylation of S6K1, 4E-BP1 and ULK1 to drive translation/growth and suppress autophagy—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC1 signaling. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:1900181 negative regulation of protein localization to nucleus	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to retain them in the cytosol, preventing their nuclear entry; a specific mechanistic downstream effect. Reason: Downstream MiT/TFE cytosolic-retention effect of mTORC1.
GO:1905672 negative regulation of lysosome organization	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Active mTORC1 phosphorylates TFEB/TFE3 to keep them cytosolic, suppressing lysosomal/autophagy gene expression and biogenesis. Reason: Downstream MiT/TFE inhibition by mTORC1.
GO:0031929 TOR signaling	IMP PMID:15485918 Disruption of the mouse mTOR gene leads to early postimplant...	ACCEPT	Summary: mTOR is the namesake kinase of TOR signaling, transducing nutrient/growth-factor inputs into control of growth, translation and autophagy via mTORC1 and mTORC2. Reason: Core pathway directly executed by mTOR (IMP/IGI).
GO:0006468 protein phosphorylation	ISO PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	ACCEPT	Summary: mTOR catalyzes transfer of phosphate to its protein substrates within mTORC1 and mTORC2, the molecular event underlying all of its signaling outputs. Reason: Core catalytic process for a protein kinase; ISO but biologically definitive for mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0038202 TORC1 signaling	ISO PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	ACCEPT	Summary: mTORC1 signaling—phosphorylation of S6K1, 4E-BP1 and ULK1 to drive translation/growth and suppress autophagy—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC1 signaling.
GO:0038203 TORC2 signaling	ISO PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	ACCEPT	Summary: mTORC2 signaling—phosphorylation of AKT, PKC and SGK1 hydrophobic/turn motifs controlling survival, cytoskeleton and metabolism—is a core output mTOR directly mediates. Reason: Core pathway; mTOR is the catalytic effector of mTORC2 signaling (IDA-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0045860 positive regulation of protein kinase activity	ISO PMID:31915252 The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr...	KEEP AS NON CORE	Summary: By phosphorylating AGC kinases (AKT, PKC, SGK1) mTORC2 increases their activity; a downstream consequence of mTOR's core kinase function. Reason: Downstream activation of substrate kinases.
GO:0006954 inflammatory response	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: mTOR modulates inflammatory programs in immune cells through metabolic and translational control; a downstream immune phenotype (IGI). Reason: Downstream inflammatory role of mTOR.
GO:0009408 response to heat	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: mTOR signaling responds to heat/proteotoxic stress as part of cellular stress adaptation; a downstream phenotype (IGI). Reason: Stress-response context downstream of mTOR.
GO:0019228 neuronal action potential	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: mTOR signaling influences neuronal excitability/action-potential properties (e.g. via channel/translation control); a downstream neuronal phenotype (IGI). Reason: Downstream neurophysiological effect of mTOR.
GO:0048266 behavioral response to pain	IGI PMID:31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pai...	KEEP AS NON CORE	Summary: mTOR-dependent translation in sensory neurons modulates nociceptive/pain behavior; a downstream behavioral phenotype (IGI). Reason: Downstream nociceptive behavioral effect.
GO:0045335 phagocytic vesicle	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTOR localizes to phagosomes, relevant to phagosome maturation and innate-immune signaling; a peripheral compartment. Reason: Secondary vesicular localization.
GO:0034198 cellular response to amino acid starvation	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTORC1 is inactivated upon amino-acid withdrawal (loss of Rag-Ragulator lysosomal recruitment); mTOR is the sensor-effector responding to this input. Reason: Upstream nutrient input gating core mTORC1 activity.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:24011591 Phosphorylation of p62 activates the Keap1-Nrf2 pathway duri...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0010506 regulation of autophagy	IDA PMID:24011591 Phosphorylation of p62 activates the Keap1-Nrf2 pathway duri...	KEEP AS NON CORE	Summary: Generic regulation-of-autophagy; mTOR's core, well-defined role is the negative regulation captured by the specific ULK1-linked terms. Reason: Generic; specific negative-regulation terms are the informative ones.
GO:0010507 negative regulation of autophagy	ISS GO_REF:0000024	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0042752 regulation of circadian rhythm	IMP PMID:29750810 mTOR signaling regulates central and peripheral circadian cl...	KEEP AS NON CORE	Summary: mTOR signaling regulates circadian period and amplitude in the SCN and liver clocks; a downstream physiological role (IMP). Reason: Downstream circadian role of mTOR.
GO:1904059 regulation of locomotor rhythm	IMP PMID:29750810 mTOR signaling regulates central and peripheral circadian cl...	KEEP AS NON CORE	Summary: mTOR modulates circadian control of locomotor activity rhythms; a downstream behavioral-physiological phenotype (IMP). Reason: Downstream circadian-behavioral effect of mTOR.
GO:0031929 TOR signaling	ISS GO_REF:0000024	ACCEPT	Summary: mTOR is the namesake kinase of TOR signaling, transducing nutrient/growth-factor inputs into control of growth, translation and autophagy via mTORC1 and mTORC2. Reason: Core pathway directly executed by mTOR (IMP/IGI). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade	IMP PMID:18347059 Integration of protein kinases mTOR and extracellular signal...	KEEP AS NON CORE	Summary: mTOR signaling can antagonize calcineurin-NFAT signaling in immune/cardiac contexts; a downstream cross-talk effect (IMP). Reason: Downstream signaling cross-talk effect.
GO:0002296 T-helper 1 cell lineage commitment	IMP PMID:26410627 The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, ...	KEEP AS NON CORE	Summary: mTOR signaling directs Th1 lineage commitment in CD4+ T cells; a downstream immune-differentiation phenotype (IMP). Reason: Downstream immune differentiation role.
GO:0031929 TOR signaling	IGI PMID:26160071 miR-199a impairs autophagy and induces cardiac hypertrophy t...	ACCEPT	Summary: mTOR is the namesake kinase of TOR signaling, transducing nutrient/growth-factor inputs into control of growth, translation and autophagy via mTORC1 and mTORC2. Reason: Core pathway directly executed by mTOR (IMP/IGI). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0016242 negative regulation of macroautophagy	ISO PMID:25327288 Selective VPS34 inhibitor blocks autophagy and uncovers a ro...	ACCEPT	Summary: mTORC1 directly restrains macroautophagy by phosphorylating ULK1 and inhibiting the autophagy-initiation machinery when nutrients are abundant. Reason: Core; ULK1-mediated suppression of macroautophagy by mTORC1 (IMP/IBA). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	IDA PMID:12718876 GbetaL, a positive regulator of the rapamycin-sensitive path...	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0001932 regulation of protein phosphorylation	IDA PMID:17556672 Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC ...	KEEP AS NON CORE	Summary: Generic regulation-of-phosphorylation reflecting mTOR's kinase outputs; less informative than its direct Ser/Thr kinase annotations. Reason: Generic; covered by specific phosphorylation/kinase terms.
GO:0016242 negative regulation of macroautophagy	IMP PMID:23274896 Stimulation of autophagy improves endoplasmic reticulum stre...	ACCEPT	Summary: mTORC1 directly restrains macroautophagy by phosphorylating ULK1 and inhibiting the autophagy-initiation machinery when nutrients are abundant. Reason: Core; ULK1-mediated suppression of macroautophagy by mTORC1 (IMP/IBA). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0001934 positive regulation of protein phosphorylation	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: Generic statement of mTOR increasing substrate phosphorylation (e.g. AKT, S6K); the specific kinase-activity terms convey the mechanism. Reason: Generic regulatory term subsumed by mTOR's specific kinase MF.
GO:0003007 heart morphogenesis	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR-dependent cardiomyocyte growth contributes to heart morphogenesis; a downstream developmental phenotype (IMP). Reason: Downstream cardiac morphogenesis role.
GO:0003179 heart valve morphogenesis	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR signaling participates in valve development via growth/EMT control; a downstream developmental phenotype (IMP). Reason: Downstream valve morphogenesis role.
GO:0006112 energy reserve metabolic process	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTORC1 influences glycogen/energy-store metabolism as part of anabolic control; a downstream metabolic phenotype (IMP). Reason: Downstream metabolic role of mTORC1.
GO:0009791 post-embryonic development	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR is required for postnatal growth and development as a consequence of its anabolic/growth-control function. Reason: Developmental phenotype downstream of mTOR growth control.
GO:0035264 multicellular organism growth	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: Organism-level growth depends on mTORC1-driven cell growth; a whole-animal phenotype downstream of mTOR (IMP). Reason: Organismal phenotype of core cell-growth role.
GO:0048738 cardiac muscle tissue development	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR supports growth and maturation of cardiac muscle tissue; a downstream developmental phenotype (IMP). Reason: Downstream cardiac tissue development.
GO:0050882 voluntary musculoskeletal movement	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR's roles in neuromuscular growth and translation affect voluntary movement; a downstream organismal phenotype (IMP). Reason: Downstream motor phenotype of mTOR.
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	ACCEPT	Summary: mTOR regulates PI3K-AKT signaling both as the mTORC2 AKT-kinase and via mTORC1 feedback (GRB10/IRS), placing it as a direct regulator of this pathway. Reason: Core; mTOR directly sets AKT activity through mTORC2 and mTORC1 feedback. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0055013 cardiac muscle cell development	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTORC1-driven growth contributes to cardiomyocyte development/maturation; a downstream tissue phenotype (IMP). Reason: Downstream cardiomyocyte developmental role.
GO:0060048 cardiac muscle contraction	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR-dependent maintenance of cardiomyocyte growth/metabolism affects cardiac contractile function; a downstream physiological phenotype (IMP). Reason: Downstream cardiac-function phenotype of mTOR.
GO:0090559 regulation of membrane permeability	IMP PMID:25139234 Mammalian target of rapamycin is essential for cardiomyocyte...	KEEP AS NON CORE	Summary: mTOR signaling modulates ion-channel/membrane permeability in excitable cells; a downstream physiological effect (IMP). Reason: Downstream physiological effect of mTOR.
GO:0048714 positive regulation of oligodendrocyte differentiation	IMP PMID:25411504 Oligodendrocyte precursor cell-intrinsic effect of Rheb1 con...	KEEP AS NON CORE	Summary: mTOR signaling promotes oligodendrocyte differentiation and myelination programs; a downstream CNS differentiation role. Reason: Downstream CNS differentiation effect (IMP).
GO:0045670 regulation of osteoclast differentiation	IDA PMID:19440205 Transcription factor C/EBPbeta isoform ratio regulates osteo...	KEEP AS NON CORE	Summary: mTOR regulates osteoclastogenesis by adjusting CEBPB isoform expression; a downstream cell-differentiation role (IDA). Reason: Downstream differentiation effect (bone).
GO:0005515 protein binding	IPI PMID:23027611 5-HT(6) receptor recruitment of mTOR as a mechanism for pert...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0031641 regulation of myelination	IMP PMID:24101522 MicroRNA-23a promotes myelination in the central nervous sys...	KEEP AS NON CORE	Summary: mTOR controls myelination through oligodendrocyte/Schwann-cell growth and lipid synthesis; a downstream tissue-level role (IMP). Reason: Downstream myelination phenotype of mTOR.
GO:0030425 dendrite	IDA PMID:23836929 Degradation of high affinity HuD targets releases Kv1.1 mRNA...	KEEP AS NON CORE	Summary: Dendritic localization of mTOR supports local translation underlying synaptic plasticity; a neuron-specific secondary site. Reason: Neuronal localization linked to local translation.
GO:0005515 protein binding	IPI PMID:21413931 Protor-1 is required for efficient mTORC2-mediated activatio...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process	IDA PMID:23429704 Quantitative phosphoproteomics reveal mTORC1 activates de no...	KEEP AS NON CORE	Summary: mTORC1 stimulates pyrimidine synthesis via S6K1-mediated phosphorylation of CAD and pentose-phosphate-fed PRPP; a metabolic output downstream of mTORC1. Reason: Downstream anabolic process of mTORC1 signaling.
GO:0055006 cardiac cell development	IMP PMID:23342106 Mechanistic target of rapamycin (Mtor) is essential for muri...	KEEP AS NON CORE	Summary: mTOR-dependent growth is required for cardiac cell development; a tissue-specific downstream phenotype (IMP). Reason: Downstream cardiac developmental role.
GO:0010831 positive regulation of myotube differentiation	IGI PMID:19704009 Regulation of myoblast differentiation by the nuclear envelo...	KEEP AS NON CORE	Summary: mTOR signaling promotes myoblast fusion/myotube differentiation during myogenesis; a downstream developmental role (IGI). Reason: Downstream myogenic differentiation effect.
GO:0046889 positive regulation of lipid biosynthetic process	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: mTOR drives lipogenesis through SREBP1 and LPIN1 (mTORC1) and lipid synthesis programs (mTORC2); a major anabolic output downstream of mTOR. Reason: Downstream lipogenic program of mTOR signaling.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:21258367 AMPK and mTOR regulate autophagy through direct phosphorylat...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005515 protein binding	IPI PMID:21258367 AMPK and mTOR regulate autophagy through direct phosphorylat...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0010507 negative regulation of autophagy	IMP PMID:21258367 AMPK and mTOR regulate autophagy through direct phosphorylat...	ACCEPT	Summary: Under nutrient sufficiency mTORC1 phosphorylates ULK1 (Ser758) and other autophagy regulators to suppress autophagy; this inhibition is a core proximal mTOR output. Reason: Core; direct ULK1 phosphorylation by mTORC1 (IMP-supported). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031669 cellular response to nutrient levels	IDA PMID:21258367 AMPK and mTOR regulate autophagy through direct phosphorylat...	KEEP AS NON CORE	Summary: Nutrient abundance dictates mTORC1 lysosomal recruitment and activity; mTOR is the effector translating nutrient state into growth decisions. Reason: Upstream nutrient input to mTORC1.
GO:0005515 protein binding	IPI PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	MARK AS OVER ANNOTATED	Summary: Uninformative IPI 'protein binding' that does not capture mTOR's specific kinase or scaffolding role within its complexes. Reason: Generic binding term per curation guidelines; not informative.
GO:0005829 cytosol	IDA PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	ACCEPT	Summary: Soluble cytosolic pool of mTOR/mTOR complexes consistent with its peripheral-membrane association and shuttling behavior. Reason: Supported localization (IDA) for cytoplasmic mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0016605 PML body	IDA PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	KEEP AS NON CORE	Summary: PML sequesters mTOR in nuclear PML bodies to repress mTORC1 (HIF1α translation control); a regulatory localization documented by IDA. Reason: Regulatory nuclear-body localization (IDA). Supporting Evidence: UniProt:Q9JLN9 Nucleus, PML body
GO:0071456 cellular response to hypoxia	IDA PMID:16915281 PML inhibits HIF-1alpha translation and neoangiogenesis thro...	KEEP AS NON CORE	Summary: Hypoxia inhibits mTORC1 (REDD1/TSC-dependent) and triggers mTOR nuclear accumulation; mTOR is the responding effector. Reason: Upstream stress input gating mTORC1 (IDA/NAS).
GO:0043022 ribosome binding	IDA PMID:21045808 mTORC2 can associate with ribosomes to promote cotranslation...	KEEP AS NON CORE	Summary: mTORC2 associates with ribosomes to cotranslationally phosphorylate nascent AKT, and mTORC1 couples to translation; a functionally relevant but ancillary interaction. Reason: Supports cotranslational substrate phosphorylation; secondary to core kinase role.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:18347059 Integration of protein kinases mTOR and extracellular signal...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005634 nucleus	IDA PMID:18347059 Integration of protein kinases mTOR and extracellular signal...	KEEP AS NON CORE	Summary: mTOR shuttles to the nucleus and accumulates there under hypoxia; a regulated secondary localization beyond its cytoplasmic membrane sites. Reason: Regulated nuclear pool (EXP/IDA); secondary location.
GO:0005829 cytosol	IDA PMID:18347059 Integration of protein kinases mTOR and extracellular signal...	ACCEPT	Summary: Soluble cytosolic pool of mTOR/mTOR complexes consistent with its peripheral-membrane association and shuttling behavior. Reason: Supported localization (IDA) for cytoplasmic mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0018105 peptidyl-serine phosphorylation	IMP PMID:18347059 Integration of protein kinases mTOR and extracellular signal...	ACCEPT	Summary: mTOR phosphorylates serine residues of substrate peptides (e.g. AKT Ser473, 4E-BP1, ULK1 Ser758), the residue-level activity of its Ser/Thr kinase function. Reason: Core; IMP-supported residue-specific phosphorylation by mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005737 cytoplasm	ISS GO_REF:0000024	ACCEPT	Summary: mTOR is a cytoplasmic kinase that shuttles among lysosomal, ER and plasma-membrane surfaces and the cytosol/nucleus; cytoplasmic localization is experimentally established. Reason: Supported localization (EXP/ISS); mTOR carries out its kinase function in the cytoplasm. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0005764 lysosome	ISS GO_REF:0000024	MODIFY	Summary: mTOR acts at the lysosomal membrane (cytoplasmic face), not in the lysosomal lumen; the membrane component is the precise localization. Reason: Over-general; lysosomal membrane (GO:0005765) is the specific compartment for mTORC1. Proposed replacements: lysosomal membrane Supporting Evidence: UniProt:Q9JLN9 Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
GO:0005634 nucleus	IDA PMID:18381428 Lkb1 deficiency causes prostate neoplasia in the mouse.	KEEP AS NON CORE	Summary: mTOR shuttles to the nucleus and accumulates there under hypoxia; a regulated secondary localization beyond its cytoplasmic membrane sites. Reason: Regulated nuclear pool (EXP/IDA); secondary location.
GO:0006468 protein phosphorylation	ISO PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	ACCEPT	Summary: mTOR catalyzes transfer of phosphate to its protein substrates within mTORC1 and mTORC2, the molecular event underlying all of its signaling outputs. Reason: Core catalytic process for a protein kinase; ISO but biologically definitive for mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031931 TORC1 complex	ISO PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	ACCEPT	Summary: mTOR is the catalytic core of mTORC1 (with RPTOR and MLST8), the nutrient/growth-factor-responsive complex that drives anabolic growth at the lysosomal surface. Reason: Core complex; mTOR is an obligate subunit of mTORC1 (IDA/ComplexPortal CPX-4473). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0031932 TORC2 complex	ISO PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	ACCEPT	Summary: mTOR is the catalytic core of mTORC2 (with RICTOR, MAPKAP1/SIN1 and MLST8), the growth-factor-responsive complex that phosphorylates AKT/PKC/SGK hydrophobic motifs. Reason: Core complex; mTOR is an obligate subunit of mTORC2 (IDA/ComplexPortal CPX-4472). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0046777 protein autophosphorylation	ISO PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	ACCEPT	Summary: mTOR autophosphorylates (e.g. Ser2481) when assembled in mTORC1 or mTORC2, a hallmark of the active kinase used to report complex integrity. Reason: Core intrinsic kinase activity; documented mTOR autophosphorylation. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0010592 positive regulation of lamellipodium assembly	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTORC2-Rac1 signaling promotes lamellipodia formation during cell migration; a downstream motility output. Reason: Downstream mTORC2 motility effect (IDA).
GO:0030838 positive regulation of actin filament polymerization	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTORC2 promotes actin polymerization through Rac/Rho and PKC, driving cell shape and motility changes. Reason: Downstream mTORC2 cytoskeletal effect (IDA/IMP).
GO:0030838 positive regulation of actin filament polymerization	IMP PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTORC2 promotes actin polymerization through Rac/Rho and PKC, driving cell shape and motility changes. Reason: Downstream mTORC2 cytoskeletal effect (IDA/IMP).
GO:0032868 response to insulin	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTOR transduces insulin signaling into anabolic and metabolic outputs; an upstream stimulus for its complexes. Reason: Upstream growth-factor input to mTOR.
GO:0043200 response to amino acid	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: Amino-acid availability is a principal cue activating mTORC1; mTOR senses this through the lysosomal Rag machinery. Reason: Upstream nutrient cue for mTORC1.
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation	IMP PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTOR signaling can raise tyrosine phosphorylation of downstream effectors indirectly; not direct mTOR catalysis on tyrosine. Reason: Indirect downstream effect, not direct mTOR tyrosine kinase activity.
GO:0051496 positive regulation of stress fiber assembly	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTORC2-RhoA signaling promotes stress-fiber formation; a downstream cytoskeletal output. Reason: Downstream mTORC2 cytoskeletal effect (IDA).
GO:1900029 positive regulation of ruffle assembly	IDA PMID:15467718 Mammalian TOR complex 2 controls the actin cytoskeleton and ...	KEEP AS NON CORE	Summary: mTORC2-driven actin remodeling promotes membrane ruffling; a downstream cytoskeletal output. Reason: Downstream mTORC2 cytoskeletal effect (IDA).
GO:0045792 negative regulation of cell size	IGI PMID:15185396 Loss of tuberous sclerosis complex 1 (Tsc1) expression resul...	KEEP AS NON CORE	Summary: Captures contexts where mTOR loss/inhibition reduces cell size or where mTOR feedback limits growth; the directionality opposite to its dominant pro-growth role. Reason: Context/loss-of-function readout of mTOR growth control.
GO:0045792 negative regulation of cell size	ISO PMID:16286931 Regulation of neuronal morphology and function by the tumor ...	KEEP AS NON CORE	Summary: Captures contexts where mTOR loss/inhibition reduces cell size or where mTOR feedback limits growth; the directionality opposite to its dominant pro-growth role. Reason: Context/loss-of-function readout of mTOR growth control.
GO:0045792 negative regulation of cell size	IGI PMID:16286931 Regulation of neuronal morphology and function by the tumor ...	KEEP AS NON CORE	Summary: Captures contexts where mTOR loss/inhibition reduces cell size or where mTOR feedback limits growth; the directionality opposite to its dominant pro-growth role. Reason: Context/loss-of-function readout of mTOR growth control.
GO:0045859 regulation of protein kinase activity	IGI PMID:15185396 Loss of tuberous sclerosis complex 1 (Tsc1) expression resul...	KEEP AS NON CORE	Summary: mTOR modulates activity of downstream kinases through phosphorylation; regulatory consequence of its catalytic role. Reason: Downstream of core kinase activity.
GO:0016242 negative regulation of macroautophagy	IMP PMID:16714284 Autophagy is disrupted in a knock-in mouse model of juvenile...	ACCEPT	Summary: mTORC1 directly restrains macroautophagy by phosphorylating ULK1 and inhibiting the autophagy-initiation machinery when nutrients are abundant. Reason: Core; ULK1-mediated suppression of macroautophagy by mTORC1 (IMP/IBA). Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:11707573 FRAP/mTOR is required for proliferation and patterning durin...	ACCEPT	Summary: mTOR's defining catalytic activity (EC 2.7.11.1): as the kinase subunit of mTORC1/mTORC2 it phosphorylates Ser/Thr residues of 4E-BP1, S6K1, ULK1, AKT, PKC and many other substrates. Reason: Core MF; directly supported by experimental catalytic-activity assays and the EC 2.7.11.1 reaction in UniProt. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0018107 peptidyl-threonine phosphorylation	IDA PMID:11707573 FRAP/mTOR is required for proliferation and patterning durin...	ACCEPT	Summary: mTOR phosphorylates threonine residues of substrates (e.g. AKT Thr450 turn motif), part of its Ser/Thr kinase catalytic repertoire. Reason: Core; IDA-supported threonine phosphorylation by mTOR. Supporting Evidence: UniProt:Q9JLN9 Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. file:mouse/Mtor/Mtor-deep-research-falcon.md Mouse Mtor encodes mechanistic/mammalian target of rapamycin (mTOR), a PI3K-related serine/threonine kinase that nucleates two signaling complexes, mTORC1 and mTORC2.
GO:0007281 germ cell development	IDA PMID:12140361 Dissection of the c-Kit signaling pathway in mouse primordia...	KEEP AS NON CORE	Summary: mTOR-dependent growth/translation supports germ-cell development; a downstream developmental phenotype (IDA). Reason: Downstream developmental role of mTOR.

Gene Description

Existing Annotations Review

Core Functions

Acts as the catalytic kinase of mTORC1, integrating nutrient and growth-factor inputs at lysosomal membranes to regulate translation, cell growth, and autophagy.

Acts as the catalytic kinase of mTORC2, phosphorylating AGC-family kinase substrates including AKT and supporting PI3K-AKT pathway output.

References

Deep Research

Falcon

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