Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005634 nucleus	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0071943 Myc-Max complex	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0006357 regulation of transcription by RNA polymerase II	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	IBA GO_REF:0000033	PENDING	Summary: TODO: Review this GOA annotation
GO:0003700 DNA-binding transcription factor activity	IEA GO_REF:0000002	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005694 chromosome	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005730 nucleolus	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm	IEA GO_REF:0000044	PENDING	Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion	IEA GO_REF:0000108	PENDING	Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription	IEA GO_REF:0000002	PENDING	Summary: TODO: Review this GOA annotation
GO:0046983 protein dimerization activity	IEA GO_REF:0000002	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:19269368 The TRIM-NHL protein TRIM32 activates microRNAs and prevents...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:20211142 An atlas of combinatorial transcriptional regulation in mous...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:20434984 c-Myc regulates transcriptional pause release.	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:20946988 A Myc network accounts for similarities between embryonic st...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:36124234 Integrative analysis reveals histone demethylase LSD1 promot...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:9764821 The C. elegans MDL-1 and MXL-1 proteins can functionally sub...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000082 G1/S transition of mitotic cell cycle	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0000165 MAPK cascade	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0000320 re-entry into mitotic cell cycle	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0000785 chromatin	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0001046 core promoter sequence-specific DNA binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0001221 transcription coregulator binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0002082 regulation of oxidative phosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0003677 DNA binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0003690 double-stranded DNA binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0003700 DNA-binding transcription factor activity	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005730 nucleolus	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0006006 glucose metabolic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006338 chromatin remodeling	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0006351 DNA-templated transcription	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006352 DNA-templated transcription initiation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006366 transcription by RNA polymerase II	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006848 pyruvate transport	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006865 amino acid transport	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0006879 intracellular iron ion homeostasis	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0006974 DNA damage response	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0007007 inner mitochondrial membrane organization	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0007346 regulation of mitotic cell cycle	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010564 regulation of cell cycle process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0010628 positive regulation of gene expression	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0010629 negative regulation of gene expression	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0010918 positive regulation of mitochondrial membrane potential	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0014911 positive regulation of smooth muscle cell migration	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0016072 rRNA metabolic process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0032204 regulation of telomere maintenance	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0032986 protein-DNA complex disassembly	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0032991 protein-containing complex	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0043565 sequence-specific DNA binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045656 negative regulation of monocyte differentiation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045787 positive regulation of cell cycle	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045821 positive regulation of glycolytic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0046325 negative regulation of D-glucose import across plasma membrane	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0046722 lactic acid secretion	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0048147 negative regulation of fibroblast proliferation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0048661 positive regulation of smooth muscle cell proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0050679 positive regulation of epithelial cell proliferation	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0051276 chromosome organization	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0051782 negative regulation of cell division	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0060252 positive regulation of glial cell proliferation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0060633 negative regulation of transcription initiation by RNA polymerase II	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070371 ERK1 and ERK2 cascade	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0070888 E-box binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0071456 cellular response to hypoxia	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0071466 cellular response to xenobiotic stimulus	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0140297 DNA-binding transcription factor binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1901857 positive regulation of cellular respiration	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1902895 positive regulation of miRNA transcription	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:1903862 positive regulation of oxidative phosphorylation	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1904036 negative regulation of epithelial cell apoptotic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:1905761 SCF ubiquitin ligase complex binding	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:2001171 positive regulation of ATP biosynthetic process	ISO GO_REF:0000096	PENDING	Summary: TODO: Review this GOA annotation
GO:0071943 Myc-Max complex	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0090571 RNA polymerase II transcription repressor complex	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:20434984 c-Myc regulates transcriptional pause release.	PENDING	Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription	IDA PMID:20434984 c-Myc regulates transcriptional pause release.	PENDING	Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	ISO GO_REF:0000119	PENDING	Summary: TODO: Review this GOA annotation
GO:0016072 rRNA metabolic process	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0032206 positive regulation of telomere maintenance	IMP PMID:9637678 Myc activates telomerase.	PENDING	Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II	IDA PMID:9637678 Myc activates telomerase.	PENDING	Summary: TODO: Review this GOA annotation
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0001866 NK T cell proliferation	IMP PMID:19423665 Intrathymic proliferation wave essential for Valpha14+ natur...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000082 G1/S transition of mitotic cell cycle	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:23277542 Domain-specific c-Myc ubiquitylation controls c-Myc transcri...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription	IDA PMID:31005419 TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cell...	PENDING	Summary: TODO: Review this GOA annotation
GO:1904672 regulation of somatic stem cell population maintenance	IDA PMID:31005419 TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cell...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	TAS Reactome:R-MMU-9634437	PENDING	Summary: TODO: Review this GOA annotation
GO:0060261 positive regulation of transcription initiation by RNA polymerase II	IDA PMID:26691508 Physical Interactions and Functional Coordination between th...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA PMID:18625840 Nucleophosmin and its AML-associated mutant regulate c-Myc t...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:26523946 Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:18625840 Nucleophosmin and its AML-associated mutant regulate c-Myc t...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:22328504 TRIM6 interacts with Myc and maintains the pluripotency of m...	PENDING	Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding	IPI PMID:22328504 TRIM6 interacts with Myc and maintains the pluripotency of m...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048471 perinuclear region of cytoplasm	IDA PMID:22328504 TRIM6 interacts with Myc and maintains the pluripotency of m...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035457 cellular response to interferon-alpha	IDA PMID:24795346 Posttranscriptional regulation of c-Myc expression in adult ...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000791 euchromatin	IDA PMID:22723415 Wnt/β-catenin signaling regulates telomerase in stem cells a...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042981 regulation of apoptotic process	IMP PMID:23277542 Domain-specific c-Myc ubiquitylation controls c-Myc transcri...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II	IDA PMID:23277542 Domain-specific c-Myc ubiquitylation controls c-Myc transcri...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:23770341 Overexpression of c-myc in hepatocytes promotes activation o...	PENDING	Summary: TODO: Review this GOA annotation
GO:0010468 regulation of gene expression	ISO PMID:21447833 TIP110/p110nrb/SART3/p110 regulation of hematopoiesis throug...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage	IDA PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage	IMP PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:2001235 positive regulation of apoptotic signaling pathway	IDA PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:2001235 positive regulation of apoptotic signaling pathway	IMP PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0035914 skeletal muscle cell differentiation	IMP PMID:22147266 Analysis of early C2C12 myogenesis identifies stably and dif...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000987 cis-regulatory region sequence-specific DNA binding	IDA PMID:15511642 A role for nucleoprotein Zap3 in the reduction of telomerase...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005515 protein binding	IPI PMID:18438430 Pim kinase-dependent inhibition of c-Myc degradation.	PENDING	Summary: TODO: Review this GOA annotation
GO:0006974 DNA damage response	IDA PMID:20212154 p38 MAPK/MK2-mediated induction of miR-34c following DNA dam...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000165 MAPK cascade	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0006338 chromatin remodeling	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0006879 intracellular iron ion homeostasis	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0006974 DNA damage response	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0032204 regulation of telomere maintenance	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0044877 protein-containing complex binding	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0045656 negative regulation of monocyte differentiation	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0048146 positive regulation of fibroblast proliferation	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0050679 positive regulation of epithelial cell proliferation	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0051276 chromosome organization	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0051782 negative regulation of cell division	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0070888 E-box binding	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:19796622 Uncovering early response of gene regulatory networks in ESC...	PENDING	Summary: TODO: Review this GOA annotation
GO:0009314 response to radiation	IMP PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0016055 Wnt signaling pathway	IDA PMID:19056892 A functional link between Wnt signaling and SKP2-independent...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0005730 nucleolus	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0045893 positive regulation of DNA-templated transcription	ISS GO_REF:0000024	PENDING	Summary: TODO: Review this GOA annotation
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation	IMP PMID:19161241 C-myc as a modulator of renal stem/progenitor cell populatio...	PENDING	Summary: TODO: Review this GOA annotation
GO:0001658 branching involved in ureteric bud morphogenesis	IMP PMID:19161241 C-myc as a modulator of renal stem/progenitor cell populatio...	PENDING	Summary: TODO: Review this GOA annotation
GO:0002053 positive regulation of mesenchymal cell proliferation	IMP PMID:19161241 C-myc as a modulator of renal stem/progenitor cell populatio...	PENDING	Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II	IDA PMID:12196193 c-Myc represses the murine Nramp1 promoter.	PENDING	Summary: TODO: Review this GOA annotation
GO:0030424 axon	IDA PMID:10482234 Requirement for the homeobox gene Hb9 in the consolidation o...	PENDING	Summary: TODO: Review this GOA annotation
GO:0002904 positive regulation of B cell apoptotic process	IGI PMID:11604501 Bax loss impairs Myc-induced apoptosis and circumvents the s...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	IDA PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	IGI PMID:17596282 Unique mechanisms of growth regulation and tumor suppression...	PENDING	Summary: TODO: Review this GOA annotation
GO:0043085 positive regulation of catalytic activity	IMP PMID:17382917 c-Myc is essential for urokinase plasminogen activator expre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II	IMP PMID:17382917 c-Myc is essential for urokinase plasminogen activator expre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0010468 regulation of gene expression	IDA PMID:11438662 Apoptosis triggered by Myc-induced suppression of Bcl-X(L) o...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:17631878 Epidermal hyperplasia and expansion of the interfollicular s...	PENDING	Summary: TODO: Review this GOA annotation
GO:0001783 B cell apoptotic process	IMP PMID:12970677 c-Myc-deficient B lymphocytes are resistant to spontaneous a...	PENDING	Summary: TODO: Review this GOA annotation
GO:0016485 protein processing	IMP PMID:12970677 c-Myc-deficient B lymphocytes are resistant to spontaneous a...	PENDING	Summary: TODO: Review this GOA annotation
GO:0043279 response to alkaloid	IMP PMID:12970677 c-Myc-deficient B lymphocytes are resistant to spontaneous a...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042474 middle ear morphogenesis	IMP PMID:17523175 Neural crest cell deficiency of c-myc causes skull and heari...	PENDING	Summary: TODO: Review this GOA annotation
GO:0043473 pigmentation	IMP PMID:17523175 Neural crest cell deficiency of c-myc causes skull and heari...	PENDING	Summary: TODO: Review this GOA annotation
GO:0048705 skeletal system morphogenesis	IMP PMID:17523175 Neural crest cell deficiency of c-myc causes skull and heari...	PENDING	Summary: TODO: Review this GOA annotation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound	IMP PMID:17523175 Neural crest cell deficiency of c-myc causes skull and heari...	PENDING	Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription	IGI PMID:8521822 Mad3 and Mad4: novel Max-interacting transcriptional repress...	PENDING	Summary: TODO: Review this GOA annotation
GO:0016604 nuclear body	IDA PMID:15735755 PML interacts with Myc, and Myc target gene expression is al...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	ISO PMID:15994933 Identification of a novel c-Myc protein interactor, JPO2, wi...	PENDING	Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation	ISO PMID:15994933 Identification of a novel c-Myc protein interactor, JPO2, wi...	PENDING	Summary: TODO: Review this GOA annotation
GO:0003677 DNA binding	IDA PMID:12970171 Deletion of Mnt leads to disrupted cell cycle control and tu...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005819 spindle	IDA PMID:15509711 Serine-threonine kinases and transcription factors active in...	PENDING	Summary: TODO: Review this GOA annotation
GO:0009314 response to radiation	IDA PMID:14517295 c-Myc augments gamma irradiation-induced apoptosis by suppre...	PENDING	Summary: TODO: Review this GOA annotation
GO:0003677 DNA binding	IDA PMID:14560010 Miz1 is required for early embryonic development during gast...	PENDING	Summary: TODO: Review this GOA annotation
GO:0042981 regulation of apoptotic process	IDA PMID:12235125 Beta-catenin-induced melanoma growth requires the downstream...	PENDING	Summary: TODO: Review this GOA annotation
GO:0005634 nucleus	IDA PMID:11872843 Colorectal cancer in mice genetically deficient in the mucin...	PENDING	Summary: TODO: Review this GOA annotation

References

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000096

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000119

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

PMID:10482234

Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity.

PMID:11438662

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis.

PMID:11604501

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.

PMID:11872843

Colorectal cancer in mice genetically deficient in the mucin Muc2.

PMID:12196193

c-Myc represses the murine Nramp1 promoter.

PMID:12235125

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor.

PMID:12970171

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.

PMID:12970677

c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death.

PMID:14517295

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.

PMID:14560010

Miz1 is required for early embryonic development during gastrulation.

PMID:15509711

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.

PMID:15511642

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.

PMID:15735755

PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.

PMID:15994933

Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.

PMID:17382917

c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells.

PMID:17523175

Neural crest cell deficiency of c-myc causes skull and hearing defects.

PMID:17596282

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.

PMID:17631878

Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1.

PMID:18438430

Pim kinase-dependent inhibition of c-Myc degradation.

PMID:18625840

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.

PMID:19056892

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.

PMID:19161241

C-myc as a modulator of renal stem/progenitor cell population.

PMID:19269368

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.

PMID:19423665

Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

PMID:19796622

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.

PMID:20211142

An atlas of combinatorial transcriptional regulation in mouse and man.

PMID:20212154

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

PMID:20434984

c-Myc regulates transcriptional pause release.

PMID:20946988

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

PMID:21447833

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.

PMID:22147266

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.

PMID:22328504

TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.

PMID:22723415

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.

PMID:23277542

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.

PMID:23770341

Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis.

PMID:24795346

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response.

PMID:26523946

Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.

PMID:26691508

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.

PMID:31005419

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.

PMID:36124234

Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing.

PMID:8521822

Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

PMID:9637678

Myc activates telomerase.

PMID:9764821

The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX.

Reactome:R-MMU-9634437

Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa

📚 Additional Documentation

Deep Research Bioreason

(Myc-deep-research-bioreason.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:29 AM

Organism: Mus musculus

Sequence:

MDFLWALETPQTATTMPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLLRKRREQLKHKLEQLRNSGA

Thinking Trace

I begin with the InterPro architecture. Two broad family signatures, IPR002418 (Transcription regulator Myc family, residues 16–452) and IPR050433 (Myc family transcription factors, residues 22–452), cover nearly the entire protein, establishing membership in the Myc lineage of transcriptional regulators. Within this scaffold, IPR012682 (Transcription regulator Myc, N-terminal domain, residues 17–360) defines the characteristic N-terminal module that mediates transcriptional activation through cofactor recruitment and short linear motifs. The C-terminal half is organized around a DNA-interacting core: IPR036638 (Helix-loop-helix DNA-binding domain superfamily, residues 361–454) and IPR011598 (Myc-type basic helix-loop-helix domain, residues 369–427) together specify a basic region that contacts E-box DNA followed by an HLH dimerization module. Immediately downstream, IPR003327 (Leucine zipper, Myc, residues 423–452) provides a coiled-coil zipper that stabilizes higher-order dimers and enhances sequence-specific DNA binding and promoter selectivity. The ordered layout—N-terminal activation domain leading into a C-terminal bHLH followed by a leucine zipper—creates a modular transcription factor that binds E-box motifs and recruits transcriptional machinery.

This domain architecture dictates molecular function. The bHLH and leucine-zipper ensemble (IPR036638, IPR011598, IPR003327) causes sequence-specific DNA recognition and obligate dimerization, supporting DNA-binding transcription factor activity with RNA polymerase II specificity. The expansive N-terminal region (IPR012682) supplies interaction surfaces that assemble coactivators and chromatin regulators, reinforcing the assignment of RNA polymerase II transcription factor activity and sequence-specific DNA binding. Thus, the mechanistic core is a bHLH-zipper-driven dimer that binds regulatory DNA and modulates transcription initiation and elongation.

From function to process, Myc-family N-terminal activation modules typically stimulate gene expression programs that drive growth and biosynthesis. By recruiting coactivators and chromatin-modifying complexes via IPR012682, this factor positively regulates transcription by RNA polymerase II and broadly coordinates transcriptional outputs that promote cell proliferation and metabolic remodeling. Consequently, it participates in positive regulation of transcription and contributes to the regulation of cell population proliferation.

Cellular location follows from the need to access chromatin and RNA polymerase II. The presence of DNA-binding and activation modules necessitates a nuclear site of action, consistent with nuclear accumulation where promoter and enhancer targets reside. Therefore, the cellular component is the nucleus.

Integrating these observations yields a mechanistic hypothesis: the protein forms bHLH-zipper dimers that bind E-box elements at target promoters and enhancers, then uses its N-terminal activation domain to recruit histone acetyltransferases and chromatin remodelers, thereby enhancing RNA polymerase II transcription and driving proliferative gene programs. Likely partners include other bHLH-zipper transcription factors and co-regulators that stabilize dimers and bridge to the transcriptional apparatus, such as TRRAP-containing acetyltransferase assemblies and Mediator-associated components that together potentiate growth-associated transcriptional networks.

Functional Summary

A nuclear transcriptional regulator that uses a C-terminal basic helix-loop-helix and leucine zipper module to dimerize and bind E-box DNA elements, while an extensive N-terminal activation region recruits coactivators and chromatin-modifying complexes. Through this architecture, it stimulates RNA polymerase II–dependent transcriptional programs that promote growth and proliferation by coordinating expression of biosynthetic and cell-cycle–associated genes within the nucleus.

UniProt Summary

Is a transcriptional activator.

InterPro Domains

Transcription regulator Myc (IPR002418, family) — residues 16-452
Transcription regulator Myc, N-terminal (IPR012682, domain) — residues 17-360
Myc family transcription factors (IPR050433, family) — residues 22-452
Helix-loop-helix DNA-binding domain superfamily (IPR036638, homologous_superfamily) — residues 361-454
Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598, domain) — residues 369-427
Leucine zipper, Myc (IPR003327, domain) — residues 423-452

GO Terms

Molecular Function: molecular_function (GO:0003674), binding (GO:0005488), heterocyclic compound binding (GO:1901363), organic cyclic compound binding (GO:0097159), protein binding (GO:0005515), nucleic acid binding (GO:0003676), enzyme binding (GO:0019899), ubiquitin-like protein ligase binding (GO:0044389), transcription regulatory region nucleic acid binding (GO:0001067), DNA binding (GO:0003677), ubiquitin protein ligase binding (GO:0031625), double-stranded DNA binding (GO:0003690), sequence-specific DNA binding (GO:0043565), transcription cis-regulatory region binding (GO:0000976), sequence-specific double-stranded DNA binding (GO:1990837), cis-regulatory region sequence-specific DNA binding (GO:0000987), RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)

Biological Process: biological_process (GO:0008150), positive regulation of biological process (GO:0048518), regulation of biological process (GO:0050789), signaling (GO:0023052), multicellular organismal process (GO:0032501), biological regulation (GO:0065007), response to stimulus (GO:0050896), developmental process (GO:0032502), cellular process (GO:0009987), pigmentation (GO:0043473), metabolic process (GO:0008152), immune system process (GO:0002376), negative regulation of biological process (GO:0048519), response to external stimulus (GO:0009605), anatomical structure development (GO:0048856), anatomical structure morphogenesis (GO:0009653), response to chemical (GO:0042221), leukocyte activation (GO:0045321), cell population proliferation (GO:0008283), positive regulation of multicellular organismal process (GO:0051240), nitrogen compound metabolic process (GO:0006807), regulation of multicellular organismal process (GO:0051239), negative regulation of metabolic process (GO:0009892), cell-cell signaling (GO:0007267), regulation of developmental process (GO:0050793), positive regulation of cellular process (GO:0048522), cell death (GO:0008219), regulation of cellular process (GO:0050794), regulation of response to stimulus (GO:0048583), cellular response to stimulus (GO:0051716), regulation of signaling (GO:0023051), negative regulation of cellular process (GO:0048523), signal transduction (GO:0007165), cellular developmental process (GO:0048869), response to abiotic stimulus (GO:0009628), positive regulation of signaling (GO:0023056), cell activation (GO:0001775), multicellular organism development (GO:0007275), biosynthetic process (GO:0009058), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), organic substance metabolic process (GO:0071704), system process (GO:0003008), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), regulation of molecular function (GO:0065009), response to stress (GO:0006950), detection of stimulus (GO:0051606), morphogenesis of a branching structure (GO:0001763), positive regulation of developmental process (GO:0051094), cell communication (GO:0007154), primary metabolic process (GO:0044238), detection of external stimulus (GO:0009581), positive regulation of cell death (GO:0010942), tissue morphogenesis (GO:0048729), programmed cell death (GO:0012501), response to radiation (GO:0009314), response to xenobiotic stimulus (GO:0009410), cell differentiation (GO:0030154), system development (GO:0048731), animal organ development (GO:0048513), regulation of signal transduction (GO:0009966), regulation of macromolecule metabolic process (GO:0060255), detection of abiotic stimulus (GO:0009582), cellular aromatic compound metabolic process (GO:0006725), regulation of binding (GO:0051098), lymphocyte activation (GO:0046649), tube development (GO:0035295), animal organ morphogenesis (GO:0009887), organic cyclic compound metabolic process (GO:1901360), leukocyte proliferation (GO:0070661), negative regulation of macromolecule metabolic process (GO:0010605), apoptotic signaling pathway (GO:0097190), nephron morphogenesis (GO:0072028), regulation of nitrogen compound metabolic process (GO:0051171), cell surface receptor signaling pathway (GO:0007166), embryo development (GO:0009790), nephron development (GO:0072006), positive regulation of cell population proliferation (GO:0008284), positive regulation of nitrogen compound metabolic process (GO:0051173), tube morphogenesis (GO:0035239), positive regulation of signal transduction (GO:0009967), regulation of catalytic activity (GO:0050790), negative regulation of nitrogen compound metabolic process (GO:0051172), positive regulation of molecular function (GO:0044093), organic substance biosynthetic process (GO:1901576), organonitrogen compound metabolic process (GO:1901564), intracellular signal transduction (GO:0035556), positive regulation of macromolecule metabolic process (GO:0010604), cell-cell signaling by wnt (GO:0198738), heterocycle metabolic process (GO:0046483), negative regulation of molecular function (GO:0044092), protein metabolic process (GO:0019538), cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114), morphogenesis of a branching epithelium (GO:0061138), cellular biosynthetic process (GO:0044249), cellular nitrogen compound metabolic process (GO:0034641), negative regulation of cellular metabolic process (GO:0031324), response to organic substance (GO:0010033), macromolecule metabolic process (GO:0043170), detection of stimulus involved in sensory perception (GO:0050906), positive regulation of biosynthetic process (GO:0009891), muscle structure development (GO:0061061), embryonic morphogenesis (GO:0048598), regulation of cell population proliferation (GO:0042127), regulation of cell death (GO:0010941), tissue development (GO:0009888), response to nitrogen compound (GO:1901698), nucleobase-containing compound metabolic process (GO:0006139), positive regulation of cellular metabolic process (GO:0031325), regulation of cell communication (GO:0010646), cellular response to chemical stimulus (GO:0070887), cellular response to stress (GO:0033554), epithelial cell proliferation (GO:0050673), regulation of biosynthetic process (GO:0009889), regulation of cellular metabolic process (GO:0031323), negative regulation of biosynthetic process (GO:0009890), positive regulation of cell communication (GO:0010647), nervous system process (GO:0050877), regulation of primary metabolic process (GO:0080090), response to mechanical stimulus (GO:0009612), regulation of kidney development (GO:0090183), regulation of stem cell population maintenance (GO:2000036), macromolecule biosynthetic process (GO:0009059), organic cyclic compound biosynthetic process (GO:1901362), epithelial tube morphogenesis (GO:0060562), skeletal system morphogenesis (GO:0048705), nephron epithelium development (GO:0072009), regulation of macromolecule biosynthetic process (GO:0010556), negative regulation of binding (GO:0051100), regulation of protein metabolic process (GO:0051246), regulation of programmed cell death (GO:0043067), Wnt signaling pathway (GO:0016055), nephron epithelium morphogenesis (GO:0072088), sensory organ morphogenesis (GO:0090596), positive regulation of mesenchymal cell proliferation (GO:0002053), morphogenesis of an epithelium (GO:0002009), detection of mechanical stimulus (GO:0050982), regulation of protein binding (GO:0043393), regulation of epithelial cell proliferation (GO:0050678), kidney morphogenesis (GO:0060993), regulation of gene expression (GO:0010468), detection of mechanical stimulus involved in sensory perception of sound (GO:0050910), branching morphogenesis of an epithelial tube (GO:0048754), detection of mechanical stimulus involved in sensory perception (GO:0050974), embryonic organ development (GO:0048568), renal tubule development (GO:0061326), skeletal system development (GO:0001501), muscle cell differentiation (GO:0042692), nucleic acid metabolic process (GO:0090304), heterocycle biosynthetic process (GO:0018130), intrinsic apoptotic signaling pathway (GO:0097193), mesonephric tubule development (GO:0072164), negative regulation of cellular biosynthetic process (GO:0031327), regulation of RNA metabolic process (GO:0051252), positive regulation of catalytic activity (GO:0043085), negative regulation of nucleobase-containing compound metabolic process (GO:0045934), gene expression (GO:0010467), renal system development (GO:0072001), response to cytokine (GO:0034097), cellular response to xenobiotic stimulus (GO:0071466), lymphocyte proliferation (GO:0046651), proteolysis (GO:0006508), regulation of DNA metabolic process (GO:0051052), cellular response to DNA damage stimulus (GO:0006974), cellular response to organic substance (GO:0071310), positive regulation of DNA metabolic process (GO:0051054), embryonic organ morphogenesis (GO:0048562), regulation of hydrolase activity (GO:0051336), positive regulation of programmed cell death (GO:0043068), aromatic compound biosynthetic process (GO:0019438), sensory organ development (GO:0007423), positive regulation of apoptotic signaling pathway (GO:2001235), protein maturation (GO:0051604), middle ear morphogenesis (GO:0042474), regulation of mesenchymal cell proliferation (GO:0010464), regulation of apoptotic signaling pathway (GO:2001233), mononuclear cell proliferation (GO:0032943), sensory perception (GO:0007600), skeletal muscle cell differentiation (GO:0035914), positive regulation of epithelial cell proliferation (GO:0050679), nucleobase-containing compound biosynthetic process (GO:0034654), positive regulation of macromolecule biosynthetic process (GO:0010557), positive regulation of nucleobase-containing compound metabolic process (GO:0045935), positive regulation of RNA metabolic process (GO:0051254), response to organonitrogen compound (GO:0010243), muscle tissue development (GO:0060537), apoptotic process (GO:0006915), regulation of cellular biosynthetic process (GO:0031326), positive regulation of protein metabolic process (GO:0051247), T cell activation (GO:0042110), regulation of nucleobase-containing compound metabolic process (GO:0019219), negative regulation of macromolecule biosynthetic process (GO:0010558), cellular nitrogen compound biosynthetic process (GO:0044271), regulation of transferase activity (GO:0051338), muscle organ development (GO:0007517), epithelium development (GO:0060429), negative regulation of RNA metabolic process (GO:0051253), kidney development (GO:0001822), positive regulation of cellular biosynthetic process (GO:0031328), regulation of telomerase activity (GO:0051972), nephron tubule development (GO:0072080), regulation of apoptotic process (GO:0042981), RNA metabolic process (GO:0016070), regulation of proteolysis (GO:0030162), mesonephros development (GO:0001823), regulation of peptidase activity (GO:0052547), regulation of RNA biosynthetic process (GO:2001141), ear development (GO:0043583), cellular response to cytokine stimulus (GO:0071345), positive regulation of DNA biosynthetic process (GO:2000573), skeletal muscle tissue development (GO:0007519), renal tubule morphogenesis (GO:0061333), T cell proliferation (GO:0042098), branching involved in ureteric bud morphogenesis (GO:0001658), intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630), ureteric bud development (GO:0001657), positive regulation of RNA biosynthetic process (GO:1902680), positive regulation of hydrolase activity (GO:0051345), negative regulation of RNA biosynthetic process (GO:1902679), mesonephric tubule morphogenesis (GO:0072171), positive regulation of apoptotic process (GO:0043065), response to alkaloid (GO:0043279), positive regulation of transferase activity (GO:0051347), skeletal muscle organ development (GO:0060538), kidney epithelium development (GO:0072073), regulation of DNA-templated transcription (GO:0006355), ear morphogenesis (GO:0042471), positive regulation of proteolysis (GO:0045862), striated muscle cell differentiation (GO:0051146), regulation of DNA biosynthetic process (GO:2000278), leukocyte apoptotic process (GO:0071887), response to interferon-alpha (GO:0035455), RNA biosynthetic process (GO:0032774), nucleic acid-templated transcription (GO:0097659), sensory perception of mechanical stimulus (GO:0050954), nephron tubule morphogenesis (GO:0072078), alpha-beta T cell activation (GO:0046631), protein processing (GO:0016485), negative regulation of protein binding (GO:0032091), positive regulation of peptidase activity (GO:0010952), regulation of endopeptidase activity (GO:0052548), myotube differentiation (GO:0014902), negative regulation of DNA-templated transcription (GO:0045892), positive regulation of leukocyte apoptotic process (GO:2000108), lymphocyte apoptotic process (GO:0070227), sensory perception of sound (GO:0007605), ureteric bud morphogenesis (GO:0060675), mesonephric epithelium development (GO:0072163), positive regulation of nucleic acid-templated transcription (GO:1903508), positive regulation of telomerase activity (GO:0051973), regulation of leukocyte apoptotic process (GO:2000106), regulation of nucleic acid-templated transcription (GO:1903506), DNA-templated transcription (GO:0006351), cellular response to interferon-alpha (GO:0035457), regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of DNA-templated transcription (GO:0045893), regulation of DNA-templated transcription initiation (GO:2000142), negative regulation of nucleic acid-templated transcription (GO:1903507), positive regulation of DNA-templated transcription initiation (GO:2000144), positive regulation of transcription by RNA polymerase II (GO:0045944), regulation of lymphocyte apoptotic process (GO:0070228), negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription initiation by RNA polymerase II (GO:0060260), transcription by RNA polymerase II (GO:0006366), positive regulation of endopeptidase activity (GO:0010950), regulation of cysteine-type endopeptidase activity (GO:2000116), positive regulation of lymphocyte apoptotic process (GO:0070230), positive regulation of transcription initiation by RNA polymerase II (GO:0060261), positive regulation of cysteine-type endopeptidase activity (GO:2001056), regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281), regulation of B cell apoptotic process (GO:0002902), positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280), activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)

Cellular Component: cellular_component (GO:0005575), protein-containing complex (GO:0032991), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), cell projection (GO:0042995), chromatin (GO:0000785), perinuclear region of cytoplasm (GO:0048471), nuclear protein-containing complex (GO:0140513), cytoplasm (GO:0005737), transcription regulator complex (GO:0005667), membrane-enclosed lumen (GO:0031974), nuclear body (GO:0016604), nucleoplasm (GO:0005654), euchromatin (GO:0000791), plasma membrane bounded cell projection (GO:0120025), intracellular organelle (GO:0043229), RNA polymerase II transcription regulator complex (GO:0090575), non-membrane-bounded organelle (GO:0043228), organelle lumen (GO:0043233), membrane-bounded organelle (GO:0043227), intracellular membrane-bounded organelle (GO:0043231), intracellular non-membrane-bounded organelle (GO:0043232), neuron projection (GO:0043005), intracellular organelle lumen (GO:0070013), nucleus (GO:0005634), cytoskeleton (GO:0005856), nuclear lumen (GO:0031981), spindle (GO:0005819), chromosome (GO:0005694), axon (GO:0030424), microtubule cytoskeleton (GO:0015630)

Generated by BioReason

Deep Research Bioreason Rl

(Myc-deep-research-bioreason-rl.md)

BioReason Chat Export

Exported on March 22, 2026 at 01:29 AM

Organism: Mus musculus

Sequence:

MDFLWALETPQTATTMPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLLRKRREQLKHKLEQLRNSGA

Thinking Trace

Functional Summary

UniProt Summary

Is a transcriptional activator.

InterPro Domains

Transcription regulator Myc (IPR002418, family) — residues 16-452
Transcription regulator Myc, N-terminal (IPR012682, domain) — residues 17-360
Myc family transcription factors (IPR050433, family) — residues 22-452
Helix-loop-helix DNA-binding domain superfamily (IPR036638, homologous_superfamily) — residues 361-454
Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598, domain) — residues 369-427
Leucine zipper, Myc (IPR003327, domain) — residues 423-452

GO Terms

Generated by BioReason

Bioreason Rl Review

(Myc-bioreason-rl-review.md)

BioReason-Pro RL Review: Myc (mouse)

Source: Myc-deep-research-bioreason-rl.md

Correctness: 5/5
Completeness: 4/5

Functional Summary Review

The BioReason functional summary is accurate and well-constructed:

A nuclear transcriptional regulator that uses a C-terminal basic helix-loop-helix and leucine zipper module to dimerize and bind E-box DNA elements, while an extensive N-terminal activation region recruits coactivators and chromatin-modifying complexes. Through this architecture, it stimulates RNA polymerase II-dependent transcriptional programs that promote growth and proliferation by coordinating expression of biosynthetic and cell-cycle-associated genes within the nucleus.

This correctly identifies: (1) the bHLH-leucine zipper DNA-binding/dimerization module, (2) the N-terminal transactivation domain, (3) E-box binding specificity, (4) RNA polymerase II transcriptional activation, (5) nuclear localization, and (6) the biological output of growth and proliferation gene programs. These align with curated annotations including GO:0003700 (DNA-binding transcription factor activity, via GO_REF:0000002), GO:0005634 (nucleus), and GO:0006355 (regulation of DNA-templated transcription, via GO_REF:0000002).

The mention of "chromatin-modifying complexes" is accurate -- Myc recruits TRRAP/HAT complexes. The description of coordinating "biosynthetic and cell-cycle-associated genes" captures the established Myc transcriptional program well.

Minor gaps: The summary does not mention the obligate heterodimerization partner Max, which is essential for Myc's DNA-binding activity. The curated review includes GO:0046983 (protein dimerization activity, via GO_REF:0000002). Myc's roles in apoptosis induction (when survival signals are absent) and its involvement in ribosome biogenesis are also omitted.

Comparison with interpro2go:

The curated review has three GO_REF:0000002 annotations: GO:0003700 (DNA-binding transcription factor activity), GO:0006355 (regulation of DNA-templated transcription), and GO:0046983 (protein dimerization activity). BioReason's summary is fully consistent with the first two and implicitly covers the third (dimerization via the bHLH-leucine zipper). BioReason adds mechanistic context about E-box binding and chromatin modifier recruitment that interpro2go cannot provide. However, the explicit dimerization function could have been stated more clearly.

Notes on thinking trace

The trace correctly identifies the Myc-family N-terminal activation domain (IPR012682) and the bHLH-zip C-terminal architecture. The hypothesis about TRRAP-containing acetyltransferase assemblies and Mediator components is accurate and shows good biological knowledge integration. The reasoning chain from domain architecture to transcriptional activation to growth programs is well-constructed.

📄 View Raw YAML

id: P01108
gene_symbol: Myc
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:10090
  label: Mus musculus
description: 'TODO: Add description for Myc'
alternative_products:
- name: 2 (c-myc 1 {ECO:0000303|PubMed:3277717})
  id: P01108-1
- name: 1 (c-myc 2 {ECO:0000303|PubMed:3277717})
  id: P01108-2
  sequence_note: VSP_061781
- name: '3'
  id: P01108-3
  sequence_note: VSP_061782
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071943
    label: Myc-Max complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000978
    label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006357
    label: regulation of transcription by RNA polymerase II
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000981
    label: DNA-binding transcription factor activity, RNA polymerase II-specific
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003700
    label: DNA-binding transcription factor activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005694
    label: chromosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005739
    label: mitochondrion
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006355
    label: regulation of DNA-templated transcription
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046983
    label: protein dimerization activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19269368
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20211142
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20434984
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20946988
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:36124234
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9764821
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000082
    label: G1/S transition of mitotic cell cycle
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000320
    label: re-entry into mitotic cell cycle
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000785
    label: chromatin
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000978
    label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000981
    label: DNA-binding transcription factor activity, RNA polymerase II-specific
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001046
    label: core promoter sequence-specific DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001221
    label: transcription coregulator binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001227
    label: DNA-binding transcription repressor activity, RNA polymerase II-specific
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001228
    label: DNA-binding transcription activator activity, RNA polymerase II-specific
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002082
    label: regulation of oxidative phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003690
    label: double-stranded DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003700
    label: DNA-binding transcription factor activity
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006006
    label: glucose metabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006338
    label: chromatin remodeling
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006351
    label: DNA-templated transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006352
    label: DNA-templated transcription initiation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006355
    label: regulation of DNA-templated transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006366
    label: transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006848
    label: pyruvate transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006865
    label: amino acid transport
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006879
    label: intracellular iron ion homeostasis
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007007
    label: inner mitochondrial membrane organization
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007346
    label: regulation of mitotic cell cycle
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010564
    label: regulation of cell cycle process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010918
    label: positive regulation of mitochondrial membrane potential
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0014911
    label: positive regulation of smooth muscle cell migration
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016072
    label: rRNA metabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032204
    label: regulation of telomere maintenance
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032986
    label: protein-DNA complex disassembly
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032991
    label: protein-containing complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043565
    label: sequence-specific DNA binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044027
    label: negative regulation of gene expression via chromosomal CpG island methylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045656
    label: negative regulation of monocyte differentiation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045787
    label: positive regulation of cell cycle
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045821
    label: positive regulation of glycolytic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045893
    label: positive regulation of DNA-templated transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045893
    label: positive regulation of DNA-templated transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046325
    label: negative regulation of D-glucose import across plasma membrane
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046722
    label: lactic acid secretion
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048146
    label: positive regulation of fibroblast proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048146
    label: positive regulation of fibroblast proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048147
    label: negative regulation of fibroblast proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048661
    label: positive regulation of smooth muscle cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050679
    label: positive regulation of epithelial cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051276
    label: chromosome organization
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051782
    label: negative regulation of cell division
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060252
    label: positive regulation of glial cell proliferation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060633
    label: negative regulation of transcription initiation by RNA polymerase II
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070371
    label: ERK1 and ERK2 cascade
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070888
    label: E-box binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071456
    label: cellular response to hypoxia
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071466
    label: cellular response to xenobiotic stimulus
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140297
    label: DNA-binding transcription factor binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1901857
    label: positive regulation of cellular respiration
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902255
    label: positive regulation of intrinsic apoptotic signaling pathway by p53 class
      mediator
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1902895
    label: positive regulation of miRNA transcription
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1903862
    label: positive regulation of oxidative phosphorylation
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904036
    label: negative regulation of epithelial cell apoptotic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1905761
    label: SCF ubiquitin ligase complex binding
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001171
    label: positive regulation of ATP biosynthetic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000096
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071943
    label: Myc-Max complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090571
    label: RNA polymerase II transcription repressor complex
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:20434984
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045893
    label: positive regulation of DNA-templated transcription
  evidence_type: IDA
  original_reference_id: PMID:20434984
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: ISO
  original_reference_id: GO_REF:0000119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016072
    label: rRNA metabolic process
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032206
    label: positive regulation of telomere maintenance
  evidence_type: IMP
  original_reference_id: PMID:9637678
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:9637678
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000981
    label: DNA-binding transcription factor activity, RNA polymerase II-specific
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001866
    label: NK T cell proliferation
  evidence_type: IMP
  original_reference_id: PMID:19423665
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000082
    label: G1/S transition of mitotic cell cycle
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23277542
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006355
    label: regulation of DNA-templated transcription
  evidence_type: IDA
  original_reference_id: PMID:31005419
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904672
    label: regulation of somatic stem cell population maintenance
  evidence_type: IDA
  original_reference_id: PMID:31005419
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-MMU-9634437
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060261
    label: positive regulation of transcription initiation by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:26691508
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000978
    label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  evidence_type: IDA
  original_reference_id: PMID:18625840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26523946
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:18625840
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:22328504
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:22328504
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:22328504
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035457
    label: cellular response to interferon-alpha
  evidence_type: IDA
  original_reference_id: PMID:24795346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000791
    label: euchromatin
  evidence_type: IDA
  original_reference_id: PMID:22723415
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042981
    label: regulation of apoptotic process
  evidence_type: IMP
  original_reference_id: PMID:23277542
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:23277542
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:23770341
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010468
    label: regulation of gene expression
  evidence_type: ISO
  original_reference_id: PMID:21447833
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008630
    label: intrinsic apoptotic signaling pathway in response to DNA damage
  evidence_type: IDA
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008630
    label: intrinsic apoptotic signaling pathway in response to DNA damage
  evidence_type: IMP
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001235
    label: positive regulation of apoptotic signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2001235
    label: positive regulation of apoptotic signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035914
    label: skeletal muscle cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:22147266
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000987
    label: cis-regulatory region sequence-specific DNA binding
  evidence_type: IDA
  original_reference_id: PMID:15511642
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18438430
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: IDA
  original_reference_id: PMID:20212154
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000165
    label: MAPK cascade
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006338
    label: chromatin remodeling
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006879
    label: intracellular iron ion homeostasis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006974
    label: DNA damage response
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032204
    label: regulation of telomere maintenance
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0044877
    label: protein-containing complex binding
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045656
    label: negative regulation of monocyte differentiation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048146
    label: positive regulation of fibroblast proliferation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050679
    label: positive regulation of epithelial cell proliferation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051276
    label: chromosome organization
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051782
    label: negative regulation of cell division
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070888
    label: E-box binding
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:19796622
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0009314
    label: response to radiation
  evidence_type: IMP
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016055
    label: Wnt signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:19056892
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005730
    label: nucleolus
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045893
    label: positive regulation of DNA-templated transcription
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090096
    label: positive regulation of metanephric cap mesenchymal cell proliferation
  evidence_type: IMP
  original_reference_id: PMID:19161241
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001658
    label: branching involved in ureteric bud morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:19161241
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002053
    label: positive regulation of mesenchymal cell proliferation
  evidence_type: IMP
  original_reference_id: PMID:19161241
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: IDA
  original_reference_id: PMID:12196193
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030424
    label: axon
  evidence_type: IDA
  original_reference_id: PMID:10482234
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0002904
    label: positive regulation of B cell apoptotic process
  evidence_type: IGI
  original_reference_id: PMID:11604501
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: IDA
  original_reference_id: PMID:12235125
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: IDA
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: IGI
  original_reference_id: PMID:17596282
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043085
    label: positive regulation of catalytic activity
  evidence_type: IMP
  original_reference_id: PMID:17382917
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IMP
  original_reference_id: PMID:17382917
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010468
    label: regulation of gene expression
  evidence_type: IDA
  original_reference_id: PMID:11438662
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:17631878
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001783
    label: B cell apoptotic process
  evidence_type: IMP
  original_reference_id: PMID:12970677
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016485
    label: protein processing
  evidence_type: IMP
  original_reference_id: PMID:12970677
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043279
    label: response to alkaloid
  evidence_type: IMP
  original_reference_id: PMID:12970677
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042474
    label: middle ear morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:17523175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043473
    label: pigmentation
  evidence_type: IMP
  original_reference_id: PMID:17523175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048705
    label: skeletal system morphogenesis
  evidence_type: IMP
  original_reference_id: PMID:17523175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0050910
    label: detection of mechanical stimulus involved in sensory perception of sound
  evidence_type: IMP
  original_reference_id: PMID:17523175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006355
    label: regulation of DNA-templated transcription
  evidence_type: IGI
  original_reference_id: PMID:8521822
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016604
    label: nuclear body
  evidence_type: IDA
  original_reference_id: PMID:15735755
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: ISO
  original_reference_id: PMID:15994933
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: ISO
  original_reference_id: PMID:15994933
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: IDA
  original_reference_id: PMID:12970171
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IDA
  original_reference_id: PMID:15509711
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0009314
    label: response to radiation
  evidence_type: IDA
  original_reference_id: PMID:14517295
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003677
    label: DNA binding
  evidence_type: IDA
  original_reference_id: PMID:14560010
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042981
    label: regulation of apoptotic process
  evidence_type: IDA
  original_reference_id: PMID:12235125
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:11872843
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000096
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-rat orthologs
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
    links
  findings: []
- id: GO_REF:0000119
  title: Automated transfer of experimentally-verified manual GO annotation data to
    mouse-human orthologs
  findings: []
- id: PMID:10482234
  title: Requirement for the homeobox gene Hb9 in the consolidation of motor neuron
    identity.
  findings: []
- id: PMID:11438662
  title: Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed
    during lymphomagenesis.
  findings: []
- id: PMID:11604501
  title: Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53
    mutations during Myc-mediated lymphomagenesis.
  findings: []
- id: PMID:11872843
  title: Colorectal cancer in mice genetically deficient in the mucin Muc2.
  findings: []
- id: PMID:12196193
  title: c-Myc represses the murine Nramp1 promoter.
  findings: []
- id: PMID:12235125
  title: Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated
    transcription factor.
  findings: []
- id: PMID:12970171
  title: Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.
  findings: []
- id: PMID:12970677
  title: c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell
    death.
  findings: []
- id: PMID:14517295
  title: c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.
  findings: []
- id: PMID:14560010
  title: Miz1 is required for early embryonic development during gastrulation.
  findings: []
- id: PMID:15509711
  title: Serine-threonine kinases and transcription factors active in signal transduction
    are detected at high levels of phosphorylation during mitosis in preimplantation
    embryos and trophoblast stem cells.
  findings: []
- id: PMID:15511642
  title: A role for nucleoprotein Zap3 in the reduction of telomerase activity during
    embryonic stem cell differentiation.
  findings: []
- id: PMID:15735755
  title: PML interacts with Myc, and Myc target gene expression is altered in PML-null
    fibroblasts.
  findings: []
- id: PMID:15994933
  title: Identification of a novel c-Myc protein interactor, JPO2, with transforming
    activity in medulloblastoma cells.
  findings: []
- id: PMID:17382917
  title: c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced
    vascular smooth muscle cells.
  findings: []
- id: PMID:17523175
  title: Neural crest cell deficiency of c-myc causes skull and hearing defects.
  findings: []
- id: PMID:17596282
  title: Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation
    in the pancreas.
  findings: []
- id: PMID:17631878
  title: Epidermal hyperplasia and expansion of the interfollicular stem cell compartment
    in mutant mice with a C-terminal truncation of Patched1.
  findings: []
- id: PMID:18438430
  title: Pim kinase-dependent inhibition of c-Myc degradation.
  findings: []
- id: PMID:18625840
  title: Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through
    Fbw7 gamma.
  findings: []
- id: PMID:19056892
  title: A functional link between Wnt signaling and SKP2-independent p27 turnover
    in mammary tumors.
  findings: []
- id: PMID:19161241
  title: C-myc as a modulator of renal stem/progenitor cell population.
  findings: []
- id: PMID:19269368
  title: The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal
    in mouse neural progenitors.
  findings: []
- id: PMID:19423665
  title: Intrathymic proliferation wave essential for Valpha14+ natural killer T cell
    development depends on c-Myc.
  findings: []
- id: PMID:19796622
  title: Uncovering early response of gene regulatory networks in ESCs by systematic
    induction of transcription factors.
  findings: []
- id: PMID:20211142
  title: An atlas of combinatorial transcriptional regulation in mouse and man.
  findings: []
- id: PMID:20212154
  title: p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents
    Myc-dependent DNA replication.
  findings: []
- id: PMID:20434984
  title: c-Myc regulates transcriptional pause release.
  findings: []
- id: PMID:20946988
  title: A Myc network accounts for similarities between embryonic stem and cancer
    cell transcription programs.
  findings: []
- id: PMID:21447833
  title: TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
  findings: []
- id: PMID:22147266
  title: Analysis of early C2C12 myogenesis identifies stably and differentially expressed
    transcriptional regulators whose knock-down inhibits myoblast differentiation.
  findings: []
- id: PMID:22328504
  title: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic
    stem cells.
  findings: []
- id: PMID:22723415
  title: Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
  findings: []
- id: PMID:23277542
  title: Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic
    activity.
  findings: []
- id: PMID:23770341
  title: Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate
    cells and facilitates the onset of liver fibrosis.
  findings: []
- id: PMID:24795346
  title: Posttranscriptional regulation of c-Myc expression in adult murine HSCs during
    homeostasis and interferon-α-induced stress response.
  findings: []
- id: PMID:26523946
  title: Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically
    Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem
    Cells.
  findings: []
- id: PMID:26691508
  title: Physical Interactions and Functional Coordination between the Core Subunits
    of Set1/Mll Complexes and the Reprogramming Factors.
  findings: []
- id: PMID:31005419
  title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC
    Regulatory Network.
  findings: []
- id: PMID:36124234
  title: Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase
    II pausing.
  findings: []
- id: PMID:8521822
  title: 'Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress
    c-myc dependent transformation and are expressed during neural and epidermal differentiation.'
  findings: []
- id: PMID:9637678
  title: Myc activates telomerase.
  findings: []
- id: PMID:9764821
  title: The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate
    MAD and MAX.
  findings: []
- id: Reactome:R-MMU-9634437
  title: Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed
    by Cebpa
  findings: []

Myc

Gene Description

Existing Annotations Review

References

📚 Additional Documentation

Deep Research Bioreason

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Deep Research Bioreason Rl

BioReason Chat Export

Thinking Trace

Functional Summary

UniProt Summary

InterPro Domains

GO Terms

Bioreason Rl Review

BioReason-Pro RL Review: Myc (mouse)

Functional Summary Review

Notes on thinking trace

📄 View Raw YAML