Notch1 is the canonical mouse Notch receptor, a single-pass transmembrane protein that mediates juxtacrine cell-cell signaling. Ligand binding by DLL/JAG family proteins triggers ADAM and gamma-secretase cleavage, releasing the Notch intracellular domain (NICD), which enters the nucleus and forms an RBPJ/MAML transcriptional coactivator complex to activate target genes. In mouse, Notch1 has central roles in cell-fate decisions during embryogenesis and tissue homeostasis, with especially strong evidence for cardiovascular development, neurogenesis/gliogenesis, hematopoietic stem cell regulation, angiogenesis, and inhibition of myogenic differentiation.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0007219
Notch signaling pathway
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007411
axon guidance
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0009986
cell surface
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0043235
receptor complex
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001525
angiogenesis
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001701
in utero embryonic development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001947
heart looping
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002011
morphogenesis of an epithelial sheet
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002064
epithelial cell development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002437
inflammatory response to antigenic stimulus
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005509
calcium ion binding
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006355
regulation of DNA-templated transcription
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006959
humoral immune response
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010001
glial cell differentiation
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010718
positive regulation of epithelial to mesenchymal transition
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010720
positive regulation of cell development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0012505
endomembrane system
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016020
membrane
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030154
cell differentiation
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030326
embryonic limb morphogenesis
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030513
positive regulation of BMP signaling pathway
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030858
positive regulation of epithelial cell differentiation
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031902
late endosome membrane
|
IEA
GO_REF:0000044 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035850
epithelial cell differentiation involved in kidney development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0038023
signaling receptor activity
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042981
regulation of apoptotic process
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045165
cell fate commitment
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048589
developmental growth
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048608
reproductive structure development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048844
artery morphogenesis
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0050793
regulation of developmental process
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070986
left/right axis specification
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072012
glomerulus vasculature development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072080
nephron tubule development
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000136
regulation of cell proliferation involved in heart morphogenesis
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:17210915 Baf60c is a nuclear Notch signaling component required for t... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:21102556 RITA, a novel modulator of Notch signalling, acts via nuclea... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:22258620 Pten coordinates retinal neurogenesis by regulating Notch si... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:38891776 Pin1 Downregulation Is Involved in Excess Retinoic Acid-Indu... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:8749394 Physical interaction between a novel domain of the receptor ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001554
luteolysis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001669
acrosomal vesicle
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001837
epithelial to mesenchymal transition
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002052
positive regulation of neuroblast proliferation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002193
MAML1-RBP-Jkappa- ICN1 complex
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003151
outflow tract morphogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003184
pulmonary valve morphogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003192
mitral valve formation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003264
regulation of cardioblast proliferation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003713
transcription coactivator activity
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004888
transmembrane signaling receptor activity
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007221
positive regulation of transcription of Notch receptor target
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007283
spermatogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007507
heart development
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008284
positive regulation of cell population proliferation
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010628
positive regulation of gene expression
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010629
negative regulation of gene expression
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010667
negative regulation of cardiac muscle cell apoptotic process
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010812
negative regulation of cell-substrate adhesion
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0021515
cell differentiation in spinal cord
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031100
animal organ regeneration
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0032496
response to lipopolysaccharide
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0032966
negative regulation of collagen biosynthetic process
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035148
tube formation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035924
cellular response to vascular endothelial growth factor stimulus
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042127
regulation of cell population proliferation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042246
tissue regeneration
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042802
identical protein binding
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0043235
receptor complex
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045603
positive regulation of endothelial cell differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045662
negative regulation of myoblast differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045665
negative regulation of neuron differentiation
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045687
positive regulation of glial cell differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0046579
positive regulation of Ras protein signal transduction
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048708
astrocyte differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048709
oligodendrocyte differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0051152
positive regulation of smooth muscle cell differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060354
negative regulation of cell adhesion molecule production
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060412
ventricular septum morphogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0062043
positive regulation of cardiac epithelial to mesenchymal transition
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070374
positive regulation of ERK1 and ERK2 cascade
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071228
cellular response to tumor cell
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071372
cellular response to follicle-stimulating hormone stimulus
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0097150
neuronal stem cell population maintenance
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000048
negative regulation of cell-cell adhesion mediated by cadherin
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000737
negative regulation of stem cell differentiation
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000811
negative regulation of anoikis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2001027
negative regulation of endothelial cell chemotaxis
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001837
epithelial to mesenchymal transition
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002193
MAML1-RBP-Jkappa- ICN1 complex
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003151
outflow tract morphogenesis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003184
pulmonary valve morphogenesis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003192
mitral valve formation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003713
transcription coactivator activity
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004888
transmembrane signaling receptor activity
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007507
heart development
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008284
positive regulation of cell population proliferation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010629
negative regulation of gene expression
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010812
negative regulation of cell-substrate adhesion
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035148
tube formation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035924
cellular response to vascular endothelial growth factor stimulus
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042802
identical protein binding
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045662
negative regulation of myoblast differentiation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0046579
positive regulation of Ras protein signal transduction
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0051152
positive regulation of smooth muscle cell differentiation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060354
negative regulation of cell adhesion molecule production
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060412
ventricular septum morphogenesis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070374
positive regulation of ERK1 and ERK2 cascade
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071228
cellular response to tumor cell
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071372
cellular response to follicle-stimulating hormone stimulus
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000048
negative regulation of cell-cell adhesion mediated by cadherin
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000737
negative regulation of stem cell differentiation
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000811
negative regulation of anoikis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2001027
negative regulation of endothelial cell chemotaxis
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
IDA
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000137
negative regulation of cell proliferation involved in heart morphogenesis
|
IDA
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000137
negative regulation of cell proliferation involved in heart morphogenesis
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1990433
CSL-Notch-Mastermind transcription factor complex
|
ISO
GO_REF:0000119 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001669
acrosomal vesicle
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002052
positive regulation of neuroblast proliferation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003264
regulation of cardioblast proliferation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004888
transmembrane signaling receptor activity
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007221
positive regulation of transcription of Notch receptor target
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007283
spermatogenesis
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010628
positive regulation of gene expression
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010667
negative regulation of cardiac muscle cell apoptotic process
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0032966
negative regulation of collagen biosynthetic process
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042127
regulation of cell population proliferation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045603
positive regulation of endothelial cell differentiation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045665
negative regulation of neuron differentiation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045687
positive regulation of glial cell differentiation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048708
astrocyte differentiation
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0062043
positive regulation of cardiac epithelial to mesenchymal transition
|
ISO
GO_REF:0000096 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098685
Schaffer collateral - CA1 synapse
|
IMP
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098685
Schaffer collateral - CA1 synapse
|
IDA
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098685
Schaffer collateral - CA1 synapse
|
IMP
PMID:26635527 Notch1 Regulates Hippocampal Plasticity Through Interaction ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098685
Schaffer collateral - CA1 synapse
|
IDA
PMID:26635527 Notch1 Regulates Hippocampal Plasticity Through Interaction ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098839
postsynaptic density membrane
|
IEP
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098839
postsynaptic density membrane
|
IDA
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098839
postsynaptic density membrane
|
IDA
PMID:26635527 Notch1 Regulates Hippocampal Plasticity Through Interaction ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098978
glutamatergic synapse
|
IMP
PMID:26635527 Notch1 Regulates Hippocampal Plasticity Through Interaction ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0098978
glutamatergic synapse
|
IDA
PMID:26635527 Notch1 Regulates Hippocampal Plasticity Through Interaction ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0099565
chemical synaptic transmission, postsynaptic
|
IMP
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0099565
chemical synaptic transmission, postsynaptic
|
IDA
PMID:21315255 Activity-induced Notch signaling in neurons requires Arc/Arg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IGI
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0061344
regulation of cell adhesion involved in heart morphogenesis
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070168
negative regulation of biomineral tissue development
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:22110751 Inhibitory role of Notch1 in calcific aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010008
endosome membrane
|
TAS
Reactome:R-MMU-9793875 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010832
negative regulation of myotube differentiation
|
IMP
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0050768
negative regulation of neurogenesis
|
IMP
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071456
cellular response to hypoxia
|
IDA
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0140537
transcription regulator activator activity
|
IDA
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006357
regulation of transcription by RNA polymerase II
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060379
cardiac muscle cell myoblast differentiation
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:27719760 BLOS2 negatively regulates Notch signaling during neural and... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:18430783 Zfp64 participates in Notch signaling and regulates differen... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030163
protein catabolic process
|
IDA
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006606
protein import into nucleus
|
IDA
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010467
gene expression
|
IDA
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072538
T-helper 17 type immune response
|
IDA
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0097400
interleukin-17-mediated signaling pathway
|
IDA
PMID:28561022 IL-17 induced NOTCH1 activation in oligodendrocyte progenito... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007221
positive regulation of transcription of Notch receptor target
|
IGI
PMID:12794108 Notch-regulated ankyrin-repeat protein inhibits Notch1 signa... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007221
positive regulation of transcription of Notch receptor target
|
IGI
PMID:23160044 BCL6 controls neurogenesis through Sirt1-dependent epigeneti... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003713
transcription coactivator activity
|
IDA
PMID:17658278 Notch directly regulates Gata3 expression during T helper 2 ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003713
transcription coactivator activity
|
IDA
PMID:9111338 RBP-L, a transcription factor related to RBP-Jkappa. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003713
transcription coactivator activity
|
IDA
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070168
negative regulation of biomineral tissue development
|
IDA
PMID:23583836 Endothelial nitric oxide signaling regulates Notch1 in aorti... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0120163
negative regulation of cold-induced thermogenesis
|
IMP
PMID:25038826 Inhibition of Notch signaling promotes browning of white adi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003182
coronary sinus valve morphogenesis
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003184
pulmonary valve morphogenesis
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003332
negative regulation of extracellular matrix constituent secretion
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
IDA
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010614
negative regulation of cardiac muscle hypertrophy
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060412
ventricular septum morphogenesis
|
IMP
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1902339
positive regulation of apoptotic process involved in morphogenesis
|
IDA
PMID:26491108 Notch-Tnf signalling is required for development and homeost... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
IGI
PMID:27107132 Endothelial Notch1 Is Required for Proper Development of the... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003184
pulmonary valve morphogenesis
|
IGI
PMID:27107132 Endothelial Notch1 Is Required for Proper Development of the... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003203
endocardial cushion morphogenesis
|
IGI
PMID:27107132 Endothelial Notch1 Is Required for Proper Development of the... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048873
homeostasis of number of cells within a tissue
|
IGI
PMID:27107132 Endothelial Notch1 Is Required for Proper Development of the... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060412
ventricular septum morphogenesis
|
IGI
PMID:27107132 Endothelial Notch1 Is Required for Proper Development of the... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
IGI
PMID:23583836 Endothelial nitric oxide signaling regulates Notch1 in aorti... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:23583836 Endothelial nitric oxide signaling regulates Notch1 in aorti... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010628
positive regulation of gene expression
|
IGI
PMID:23583836 Endothelial nitric oxide signaling regulates Notch1 in aorti... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:28089369 Deciphering the Fringe-Mediated Notch Code: Identification o... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:28498977 Consequences of MEGF10 deficiency on myoblast function and N... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048845
venous blood vessel morphogenesis
|
IMP
PMID:18952909 Artery and vein size is balanced by Notch and ephrin B2/EphB... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1903849
positive regulation of aorta morphogenesis
|
IMP
PMID:18952909 Artery and vein size is balanced by Notch and ephrin B2/EphB... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010468
regulation of gene expression
|
IMP
PMID:11076679 Oscillating expression of c-Hey2 in the presomitic mesoderm ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:21191019 A protein (ORF2) encoded by the latency-related gene of bovi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045070
positive regulation of viral genome replication
|
IMP
PMID:21191019 A protein (ORF2) encoded by the latency-related gene of bovi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003197
endocardial cushion development
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:21985982 Delta-like 1-Lysine613 regulates notch signaling. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:18676613 The intracellular region of Notch ligands Dll1 and Dll3 regu... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:24715457 Cadherin-based adhesions in the apical endfoot are required ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005912
adherens junction
|
IDA
PMID:24715457 Cadherin-based adhesions in the apical endfoot are required ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016324
apical plasma membrane
|
IDA
PMID:24715457 Cadherin-based adhesions in the apical endfoot are required ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:12050162 The nephroblastoma overexpressed gene (NOV/ccn3) protein ass... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006357
regulation of transcription by RNA polymerase II
|
IMP
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
IMP
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0042127
regulation of cell population proliferation
|
IGI
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045607
regulation of inner ear auditory receptor cell differentiation
|
IMP
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045608
negative regulation of inner ear auditory receptor cell differentiation
|
IMP
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090090
negative regulation of canonical Wnt signaling pathway
|
IMP
PMID:25535395 Notch inhibition induces mitotically generated hair cells in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005112
Notch binding
|
IPI
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005783
endoplasmic reticulum
|
IDA
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
IDA
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008593
regulation of Notch signaling pathway
|
IGI
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031410
cytoplasmic vesicle
|
IDA
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045747
positive regulation of Notch signaling pathway
|
IDA
PMID:24667410 Notch4 reveals a novel mechanism regulating Notch signal tra... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0071944
cell periphery
|
IDA
PMID:23284756 Ascl1 (Mash1) knockout perturbs differentiation of nonneuron... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0043235
receptor complex
|
ISO
PMID:23382219 Structural basis for endosomal trafficking of diverse transm... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060271
cilium assembly
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1902263
apoptotic process involved in embryonic digit morphogenesis
|
IMP
PMID:16245338 Notch1 signals through Jagged2 to regulate apoptosis in the ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001726
ruffle
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005856
cytoskeleton
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030027
lamellipodium
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0008285
negative regulation of cell population proliferation
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035148
tube formation
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035924
cellular response to vascular endothelial growth factor stimulus
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090051
negative regulation of cell migration involved in sprouting angiogenesis
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2001027
negative regulation of endothelial cell chemotaxis
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035914
skeletal muscle cell differentiation
|
IMP
PMID:22147266 Analysis of early C2C12 myogenesis identifies stably and dif... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:17685488 Monitoring Notch1 activity in development: evidence for a fe... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IMP
PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:17303760 Combined loss of Hey1 and HeyL causes congenital heart defec... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003180
aortic valve morphogenesis
|
ISS
GO_REF:0000024 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003213
cardiac right atrium morphogenesis
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003241
growth involved in heart morphogenesis
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0014031
mesenchymal cell development
|
IMP
PMID:17303760 Combined loss of Hey1 and HeyL causes congenital heart defec... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030279
negative regulation of ossification
|
IMP
PMID:21493891 Diet-induced aortic valve disease in mice haploinsufficient ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IMP
PMID:19695258 Notch1 represses osteogenic pathways in aortic valve cells. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:15107403 The Notch target genes Hey1 and Hey2 are required for embryo... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0055008
cardiac muscle tissue morphogenesis
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060045
positive regulation of cardiac muscle cell proliferation
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060317
cardiac epithelial to mesenchymal transition
|
IMP
PMID:17303760 Combined loss of Hey1 and HeyL causes congenital heart defec... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060411
cardiac septum morphogenesis
|
IMP
PMID:20007915 Distinct roles for cell-autonomous Notch signaling in cardio... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060842
arterial endothelial cell differentiation
|
IMP
PMID:15107403 The Notch target genes Hey1 and Hey2 are required for embryo... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001947
heart looping
|
IGI
PMID:12730124 Notch signaling regulates left-right asymmetry determination... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003160
endocardium morphogenesis
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003162
atrioventricular node development
|
IMP
PMID:21266778 Notch signaling regulates murine atrioventricular conduction... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003169
coronary vein morphogenesis
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003181
atrioventricular valve morphogenesis
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003181
atrioventricular valve morphogenesis
|
IMP
PMID:21266778 Notch signaling regulates murine atrioventricular conduction... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003198
epithelial to mesenchymal transition involved in endocardial cushion formation
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003203
endocardial cushion morphogenesis
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003207
cardiac chamber formation
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003208
cardiac ventricle morphogenesis
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003209
cardiac atrium morphogenesis
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003214
cardiac left ventricle morphogenesis
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003273
cell migration involved in endocardial cushion formation
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003344
pericardium morphogenesis
|
IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003344
pericardium morphogenesis
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003344
pericardium morphogenesis
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010718
positive regulation of epithelial to mesenchymal transition
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030334
regulation of cell migration
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030335
positive regulation of cell migration
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060038
cardiac muscle cell proliferation
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060843
venous endothelial cell differentiation
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060948
cardiac vascular smooth muscle cell development
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060956
endocardial cell differentiation
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060979
vasculogenesis involved in coronary vascular morphogenesis
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060982
coronary artery morphogenesis
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0061384
heart trabecula morphogenesis
|
IMP
PMID:20890042 Integration of a Notch-dependent mesenchymal gene program an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070986
left/right axis specification
|
IGI
PMID:12730124 Notch signaling regulates left-right asymmetry determination... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1901201
regulation of extracellular matrix assembly
|
IMP
PMID:21311046 Differential Notch signaling in the epicardium is required f... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1901189
positive regulation of ephrin receptor signaling pathway
|
IC
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003157
endocardium development
|
IMP
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003222
ventricular trabecula myocardium morphogenesis
|
IMP
PMID:17336907 Notch signaling is essential for ventricular chamber develop... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-4396387 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-9667655 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-9824206 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-9824230 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-9824231 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-MMU-9824278 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-NUL-2064853 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-NUL-2064883 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-NUL-2065560 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005654
nucleoplasm
|
TAS
Reactome:R-NUL-4396363 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-MMU-2067638 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-MMU-209285 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-NUL-2065902 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0019899
enzyme binding
|
IPI
PMID:17573339 Asparaginyl hydroxylation of the Notch ankyrin repeat domain... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0019899
enzyme binding
|
IPI
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:19245366 MYPT1, the targeting subunit of smooth-muscle myosin phospha... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004857
enzyme inhibitor activity
|
IDA
PMID:17573339 Asparaginyl hydroxylation of the Notch ankyrin repeat domain... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:18299578 Interaction with factor inhibiting HIF-1 defines an addition... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IDA
PMID:21419176 The EGF-like proteins DLK1 and DLK2 function as inhibitory n... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0043086
negative regulation of catalytic activity
|
IDA
PMID:17573339 Asparaginyl hydroxylation of the Notch ankyrin repeat domain... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2053938 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2053963 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2066712 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2067638 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2071906 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2077477 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-MMU-2077479 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-NUL-2065902 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005576
extracellular region
|
TAS
Reactome:R-NUL-209162 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000139
Golgi membrane
|
TAS
Reactome:R-MMU-2023158 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000139
Golgi membrane
|
TAS
Reactome:R-MMU-2032750 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005789
endoplasmic reticulum membrane
|
TAS
Reactome:R-MMU-2023179 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005789
endoplasmic reticulum membrane
|
TAS
Reactome:R-MMU-2032750 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005789
endoplasmic reticulum membrane
|
TAS
Reactome:R-MMU-9824249 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005789
endoplasmic reticulum membrane
|
TAS
Reactome:R-NUL-1986584 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-209285 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-NUL-2063915 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-NUL-209162 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2053938 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:15574878 Fringe glycosyltransferases differentially modulate Notch1 p... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0009986
cell surface
|
IDA
PMID:15574878 Fringe glycosyltransferases differentially modulate Notch1 p... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002437
inflammatory response to antigenic stimulus
|
IGI
PMID:17658279 Direct regulation of Gata3 expression determines the T helpe... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006959
humoral immune response
|
IGI
PMID:17658279 Direct regulation of Gata3 expression determines the T helpe... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003219
cardiac right ventricle formation
|
IMP
PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IMP
PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090090
negative regulation of canonical Wnt signaling pathway
|
IMP
PMID:19620969 A regulatory pathway involving Notch1/beta-catenin/Isl1 dete... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:20547764 ZFP423 coordinates Notch and bone morphogenetic protein sign... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030513
positive regulation of BMP signaling pathway
|
IDA
PMID:20547764 ZFP423 coordinates Notch and bone morphogenetic protein sign... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:20547764 ZFP423 coordinates Notch and bone morphogenetic protein sign... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:2000974
negative regulation of pro-B cell differentiation
|
IMP
PMID:12032823 Overexpression of the Notch target genes Hes in vivo induces... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0046427
positive regulation of receptor signaling pathway via JAK-STAT
|
IDA
PMID:15156153 Hes binding to STAT3 mediates crosstalk between Notch and JA... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000122
negative regulation of transcription by RNA polymerase II
|
IDA
PMID:12032823 Overexpression of the Notch target genes Hes in vivo induces... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:12666205 Hes1 but not Hes5 regulates an astrocyte versus oligodendroc... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048711
positive regulation of astrocyte differentiation
|
IDA
PMID:12666205 Hes1 but not Hes5 regulates an astrocyte versus oligodendroc... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0048715
negative regulation of oligodendrocyte differentiation
|
IDA
PMID:12666205 Hes1 but not Hes5 regulates an astrocyte versus oligodendroc... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060253
negative regulation of glial cell proliferation
|
IDA
PMID:12666205 Hes1 but not Hes5 regulates an astrocyte versus oligodendroc... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072017
distal tubule development
|
IEP
PMID:15821257 Segmental expression of Notch and Hairy genes in nephrogenes... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072044
collecting duct development
|
IEP
PMID:15821257 Segmental expression of Notch and Hairy genes in nephrogenes... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072144
glomerular mesangial cell development
|
IEP
PMID:15821257 Segmental expression of Notch and Hairy genes in nephrogenes... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007219
Notch signaling pathway
|
IMP
PMID:19154718 Hey2 regulation by FGF provides a Notch-independent mechanis... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0009912
auditory receptor cell fate commitment
|
IMP
PMID:19154718 Hey2 regulation by FGF provides a Notch-independent mechanis... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045665
negative regulation of neuron differentiation
|
IGI
PMID:10205173 Hes1 and Hes5 as notch effectors in mammalian neuronal diffe... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045955
negative regulation of calcium ion-dependent exocytosis
|
IMP
PMID:19251639 Notch and Wnt signals cooperatively control cell proliferati... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0050679
positive regulation of epithelial cell proliferation
|
IGI
PMID:19251639 Notch and Wnt signals cooperatively control cell proliferati... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0032495
response to muramyl dipeptide
|
IDA
PMID:21156799 Intracellular pathogen sensor NOD2 programs macrophages to t... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030514
negative regulation of BMP signaling pathway
|
IMP
PMID:19695258 Notch1 represses osteogenic pathways in aortic valve cells. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045668
negative regulation of osteoblast differentiation
|
IMP
PMID:19695258 Notch1 represses osteogenic pathways in aortic valve cells. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0002051
osteoblast fate commitment
|
NAS
PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003160
endocardium morphogenesis
|
IEP
PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045892
negative regulation of DNA-templated transcription
|
IDA
PMID:16025100 Mutations in NOTCH1 cause aortic valve disease. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060528
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
|
IMP
PMID:16360140 Notch signaling is required for normal prostatic epithelial ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060740
prostate gland epithelium morphogenesis
|
IMP
PMID:16360140 Notch signaling is required for normal prostatic epithelial ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0060768
regulation of epithelial cell proliferation involved in prostate gland development
|
IMP
PMID:16360140 Notch signaling is required for normal prostatic epithelial ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001701
in utero embryonic development
|
IMP
PMID:7789282 Notch1 is required for the coordinate segmentation of somite... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0007368
determination of left/right symmetry
|
IMP
PMID:7789282 Notch1 is required for the coordinate segmentation of somite... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0014807
regulation of somitogenesis
|
IMP
PMID:7789282 Notch1 is required for the coordinate segmentation of somite... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0021915
neural tube development
|
IMP
PMID:7789282 Notch1 is required for the coordinate segmentation of somite... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0043069
negative regulation of programmed cell death
|
IMP
PMID:7789282 Notch1 is required for the coordinate segmentation of somite... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:16324690 BMP7 inhibits branching morphogenesis in the prostate gland ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045893
positive regulation of DNA-templated transcription
|
IDA
PMID:9111338 RBP-L, a transcription factor related to RBP-Jkappa. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly in... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:9315665 Isolation and functional analysis of a cDNA for human Jagged... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0001889
liver development
|
IMP
PMID:15226394 Notch signaling controls hepatoblast differentiation by alte... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010468
regulation of gene expression
|
IMP
PMID:9102301 Conservation of the Notch signalling pathway in mammalian ne... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0030182
neuron differentiation
|
IMP
PMID:9102301 Conservation of the Notch signalling pathway in mammalian ne... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0050767
regulation of neurogenesis
|
IMP
PMID:9102301 Conservation of the Notch signalling pathway in mammalian ne... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2053963 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2066712 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2067638 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2071906 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2077477 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-MMU-2077479 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
TAS
Reactome:R-NUL-2065902 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005634
nucleus
|
IDA
PMID:17079689 Canonical notch signaling functions as a commitment switch i... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005886
plasma membrane
|
IDA
PMID:17079689 Canonical notch signaling functions as a commitment switch i... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045618
positive regulation of keratinocyte differentiation
|
IGI
PMID:16618808 Cross-regulation between Notch and p63 in keratinocyte commi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045618
positive regulation of keratinocyte differentiation
|
IDA
PMID:17079689 Canonical notch signaling functions as a commitment switch i... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:16618808 Cross-regulation between Notch and p63 in keratinocyte commi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IGI
PMID:16618808 Cross-regulation between Notch and p63 in keratinocyte commi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031490
chromatin DNA binding
|
IDA
PMID:17658278 Notch directly regulates Gata3 expression during T helper 2 ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0045944
positive regulation of transcription by RNA polymerase II
|
IDA
PMID:17658278 Notch directly regulates Gata3 expression during T helper 2 ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0046533
negative regulation of photoreceptor cell differentiation
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IMP
PMID:16452096 Notch 1 inhibits photoreceptor production in the developing ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0005737
cytoplasm
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IDA
PMID:15965470 DNER acts as a neuron-specific Notch ligand during Bergmann ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0010001
glial cell differentiation
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IMP
PMID:15965470 DNER acts as a neuron-specific Notch ligand during Bergmann ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0005634
nucleus
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IDA
PMID:16607638 Jag2-Notch1 signaling regulates oral epithelial differentiat... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007440
foregut morphogenesis
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IMP
PMID:16107537 Direct regulation of intestinal fate by Notch. |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045165
cell fate commitment
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IMP
PMID:16107537 Direct regulation of intestinal fate by Notch. |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0050678
regulation of epithelial cell proliferation
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IMP
PMID:16107537 Direct regulation of intestinal fate by Notch. |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0002040
sprouting angiogenesis
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IMP
PMID:15809373 Essential role of endothelial Notch1 in angiogenesis. |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0031069
hair follicle morphogenesis
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IMP
PMID:15978571 Notch1 is essential for postnatal hair follicle development ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030326
embryonic limb morphogenesis
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IGI
PMID:16169548 Notch1 and 2 cooperate in limb ectoderm to receive an early ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0043065
positive regulation of apoptotic process
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IGI
PMID:16169548 Notch1 and 2 cooperate in limb ectoderm to receive an early ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0035116
embryonic hindlimb morphogenesis
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IMP
PMID:16245338 Notch1 signals through Jagged2 to regulate apoptosis in the ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045944
positive regulation of transcription by RNA polymerase II
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IDA
PMID:16145673 Fjx1: a notch-inducible secreted ligand with specific bindin... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0048754
branching morphogenesis of an epithelial tube
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IMP
PMID:15064243 Functional diversity of notch family genes in fetal lung dev... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0005634
nucleus
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IDA
PMID:10206645 A presenilin-1-dependent gamma-secretase-like protease media... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007409
axonogenesis
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IMP
PMID:16120638 Notch signaling coordinates the patterning of striatal compa... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030900
forebrain development
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IMP
PMID:16120638 Notch signaling coordinates the patterning of striatal compa... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030900
forebrain development
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IGI
PMID:16120638 Notch signaling coordinates the patterning of striatal compa... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045665
negative regulation of neuron differentiation
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IMP
PMID:16120638 Notch signaling coordinates the patterning of striatal compa... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0048663
neuron fate commitment
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IGI
PMID:16120638 Notch signaling coordinates the patterning of striatal compa... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045944
positive regulation of transcription by RNA polymerase II
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IDA
PMID:15902259 The Mesp2 transcription factor establishes segmental borders... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0001708
cell fate specification
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IMP
PMID:15068794 High commitment of embryonic keratinocytes to terminal diffe... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007409
axonogenesis
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IDA
PMID:15598981 Targeted deletion of numb and numblike in sensory neurons re... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030154
cell differentiation
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IMP
PMID:12186854 Notch1 control of oligodendrocyte differentiation in the spi... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030216
keratinocyte differentiation
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IMP
PMID:15068794 High commitment of embryonic keratinocytes to terminal diffe... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0003682
chromatin binding
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IDA
PMID:15689374 RBPjkappa-dependent Notch function regulates Gata2 and is es... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0006357
regulation of transcription by RNA polymerase II
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IGI
PMID:15689374 RBPjkappa-dependent Notch function regulates Gata2 and is es... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030324
lung development
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IMP
PMID:15064243 Functional diversity of notch family genes in fetal lung dev... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045596
negative regulation of cell differentiation
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IMP
PMID:15064243 Functional diversity of notch family genes in fetal lung dev... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0008284
positive regulation of cell population proliferation
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IGI
PMID:15509736 Fibroblast growth factor receptor signaling promotes radial ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0045944
positive regulation of transcription by RNA polymerase II
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IDA
PMID:12783854 Periodic repression by the bHLH factor Hes7 is an essential ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0048103
somatic stem cell division
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IGI
PMID:15509736 Fibroblast growth factor receptor signaling promotes radial ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0008544
epidermis development
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IGI
PMID:15525534 gamma-secretase functions through Notch signaling to maintai... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0031069
hair follicle morphogenesis
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IMP
PMID:15525534 gamma-secretase functions through Notch signaling to maintai... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0043065
positive regulation of apoptotic process
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IDA
PMID:15081359 Notch activation induces apoptosis in neural progenitor cell... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0001837
epithelial to mesenchymal transition
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IMP
PMID:14701881 Notch promotes epithelial-mesenchymal transition during card... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007492
endoderm development
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IMP
PMID:14657333 Notch signaling controls multiple steps of pancreatic differ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0030154
cell differentiation
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IMP
PMID:14657333 Notch signaling controls multiple steps of pancreatic differ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0005886
plasma membrane
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IC
PMID:10551863 Mouse jagged1 physically interacts with notch2 and other not... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007219
Notch signaling pathway
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IC
PMID:10551863 Mouse jagged1 physically interacts with notch2 and other not... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0048103
somatic stem cell division
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IDA
PMID:12717450 A role for Wnt signalling in self-renewal of haematopoietic ... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007368
determination of left/right symmetry
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IMP
PMID:12730124 Notch signaling regulates left-right asymmetry determination... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0005515
protein binding
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IPI
PMID:10551863 Mouse jagged1 physically interacts with notch2 and other not... |
PENDING |
Summary: TODO: Review this GOA annotation
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GO:0007386
compartment pattern specification
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IMP
PMID:12001066 Segmentation defects of Notch pathway mutants and absence of... |
PENDING |
Summary: TODO: Review this GOA annotation
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Exported on March 22, 2026 at 01:24 AM
Organism: Mus musculus
Sequence:
MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGGVCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDIPPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYGHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGM
I begin with the InterPro architecture. A broad family signature, IPR008297 (Notch family, residues 5–2000), blankets essentially the entire polypeptide, immediately placing the protein within the Notch receptor lineage. The N-terminal half is densely packed with extracellular EGF modules: IPR000742 (EGF-like domain, residues 20–1426), IPR001881 (EGF-like calcium-binding domain, residues 59–1384), IPR018097 (EGF-like calcium-binding conserved site, residues 178–1253), and IPR049883 (NOTCH1, EGF-like calcium-binding domain, residues 178–900). These repeated EGF repeats and their Ca2+-binding motifs generate a rigid, cysteine-rich scaffold that enforces precise intermolecular contacts and mechanosensing at the cell surface. This extracellular region is further supported by IPR009030 (Growth factor receptor cysteine-rich domain superfamily, residues 288–1311), emphasizing a disulfide-stabilized receptor fold, and by IPR000152 (EGF-type aspartate/asparagine hydroxylation site, residues 195–1255) and IPR013032 (EGF-like conserved site, residues 344–1374), which together indicate extensive post-translational hydroxylation and glycosylation typical of secreted or surface-exposed EGF arrays. This extracellular EGF architecture causes high-affinity, Ca2+-tunable binding and force-dependent activation characteristic of Notch receptors.
Proceeding into the intracellular signaling core, a series of Notch-specific modules appears: IPR022362 (Neurogenic locus notch homolog protein 1 family, residues 1426–1714) leads into IPR000800 (Notch domain, residues 1442–1571), IPR035993 (Notch-like domain superfamily, residues 1448–1561), IPR010660 (Notch, NOD domain, residues 1566–1622), and IPR011656 (Notch, NODP domain, residues 1660–1722). This ordered block encodes the canonical heterodimerization and negative regulatory apparatus of Notch receptors: the NOD/NODP cassette forms the negative regulatory region that clamps the receptor’s intracellular tail until activating endocytosis and mechanical tension unlock it. Downstream, IPR036770 (Ankyrin repeat-containing domain superfamily, residues 1858–2000) and IPR002110 (Ankyrin repeat, residues 1870–1980) specify a C-terminal ankyrin-repeat platform that binds transcriptional co-regulators. The combined evidence—extracellular EGF arrays, followed by the NOD/NODP switch and a C-terminal ankyrin scaffold—defines a single-pass type I receptor that signals by proteolytic activation and intracellular complex assembly.
From this architecture, the molecular function resolves as follows. The extracellular EGF array and calcium-binding sites enforce ligand-gated activation and support protein-protein interactions at the surface; the intracellular ankyrin repeats and the activated signaling core drive assembly of transcriptional effector complexes. This causally establishes protein binding (GO:0005515) as the operative activity: the receptor binds extracellular ligands and intracellular partners to translate a surface cue into transcriptional control.
The biological process follows from this signaling logic. Notch receptors govern binary fate decisions by inducing gene expression programs that restrain or promote differentiation. The EGF-driven activation and ankyrin-mediated transcriptional assembly together enforce control of lineage bifurcation and timing, aligning with cell fate determination (GO:0001708). This process-level inference arises directly from the coupling of an extracellular ligand-gated module to an intracellular transcriptional hub.
Cellular location is dictated by the single-pass type I topology and the extracellular EGF region. Such receptors are synthesized into the secretory pathway and displayed at the cell surface, where they function as membrane-bound signal transducers. This places the protein at the plasma membrane/cell surface and classifies it as an integral component of membrane, matching a single-pass type I membrane protein.
Mechanistically, the extracellular EGF platform binds Delta/Serrate/Jagged-type ligands on neighboring cells; endocytosis and Ca2+-stabilized EGF architecture transmit mechanical force that unlocks the NOD/NODP switch, triggering intramembrane proteolysis and liberation of the intracellular domain. The released intracellular fragment then engages the ankyrin-repeat platform to recruit CSL/RBPJ transcription complexes and coactivators, thereby rewiring gene expression to bias cell fate. Likely interaction partners include membrane ligands and extracellular modulators that deliver activation cues, as well as intracellular DNA-binding and co-regulatory assemblies that implement the transcriptional output.
A single-pass cell-surface receptor that uses a long calcium-stabilized EGF repeat array to sense extracellular cues and trigger intramembrane signaling. Upon ligand engagement and endocytic activation, a built-in regulatory switch releases the intracellular tail, which then assembles transcriptional effector complexes via ankyrin repeats to reprogram gene expression. This signaling cascade governs binary fate decisions and timing of differentiation by coupling extracellular recognition to intracellular transcriptional control at the plasma membrane.
Functions as a receptor for several membrane-bound ligands that are presented on the surface of adjacent cells. Activates transcription factors that are involved in lineage specification. May play a role in cell-fate determination (By similarity).
IPR008297, family) — residues 5-2000IPR000742, domain) — residues 20-1426IPR001881, domain) — residues 59-1384IPR018097, conserved_site) — residues 178-1253IPR049883, domain) — residues 178-900IPR000152, ptm) — residues 195-1255IPR009030, homologous_superfamily) — residues 288-1311IPR013032, conserved_site) — residues 344-1374IPR022362, family) — residues 1426-1714IPR000800, domain) — residues 1442-1571IPR035993, homologous_superfamily) — residues 1448-1561IPR010660, domain) — residues 1566-1622IPR011656, domain) — residues 1660-1722IPR036770, homologous_superfamily) — residues 1858-2000IPR002110, repeat) — residues 1870-1980Molecular Function: molecular_function (GO:0003674), molecular function regulator activity (GO:0098772), binding (GO:0005488), transcription regulator activity (GO:0140110), enzyme regulator activity (GO:0030234), molecular function activator activity (GO:0140677), heterocyclic compound binding (GO:1901363), chromatin binding (GO:0003682), organic cyclic compound binding (GO:0097159), transcription coregulator activity (GO:0003712), protein binding (GO:0005515), molecular function inhibitor activity (GO:0140678), nucleic acid binding (GO:0003676), signaling receptor binding (GO:0005102), chromatin DNA binding (GO:0031490), enzyme binding (GO:0019899), enzyme inhibitor activity (GO:0004857), transcription coactivator activity (GO:0003713), Notch binding (GO:0005112), DNA binding (GO:0003677)
Biological Process: biological_process (GO:0008150), biological regulation (GO:0065007), response to stimulus (GO:0050896), reproductive process (GO:0022414), regulation of biological process (GO:0050789), reproduction (GO:0000003), multicellular organismal process (GO:0032501), metabolic process (GO:0008152), homeostatic process (GO:0042592), immune system process (GO:0002376), localization (GO:0051179), signaling (GO:0023052), growth (GO:0040007), negative regulation of biological process (GO:0048519), positive regulation of biological process (GO:0048518), developmental process (GO:0032502), cellular process (GO:0009987), anatomical structure development (GO:0048856), negative regulation of signaling (GO:0023057), cell division (GO:0051301), developmental process involved in reproduction (GO:0003006), anatomical structure formation involved in morphogenesis (GO:0048646), multicellular organismal-level homeostasis (GO:0048871), regulation of response to stimulus (GO:0048583), negative regulation of cellular process (GO:0048523), biosynthetic process (GO:0009058), positive regulation of viral process (GO:0048524), establishment of localization (GO:0051234), catabolic process (GO:0009056), macromolecule localization (GO:0033036), developmental growth (GO:0048589), cell population proliferation (GO:0008283), nitrogen compound metabolic process (GO:0006807), negative regulation of multicellular organismal process (GO:0051241), cell death (GO:0008219), positive regulation of locomotion (GO:0040017), regulation of signaling (GO:0023051), negative regulation of developmental process (GO:0051093), signal transduction (GO:0007165), negative regulation of transport (GO:0051051), regulation of viral process (GO:0050792), primary metabolic process (GO:0044238), morphogenesis of a branching structure (GO:0001763), positive regulation of developmental process (GO:0051094), negative regulation of response to stimulus (GO:0048585), regulation of growth (GO:0040008), cellular localization (GO:0051641), immune response (GO:0006955), positive regulation of multicellular organismal process (GO:0051240), molting cycle (GO:0042303), pattern specification process (GO:0007389), cellular component organization or biogenesis (GO:0071840), regulation of multicellular organismal process (GO:0051239), negative regulation of metabolic process (GO:0009892), regulation of cellular process (GO:0050794), cellular response to stimulus (GO:0051716), regulation of locomotion (GO:0040012), cellular developmental process (GO:0048869), response to abiotic stimulus (GO:0009628), organ growth (GO:0035265), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), molting cycle process (GO:0022404), regulation of molecular function (GO:0065009), export from cell (GO:0140352), cell communication (GO:0007154), positive regulation of cellular process (GO:0048522), anatomical structure morphogenesis (GO:0009653), cell motility (GO:0048870), response to chemical (GO:0042221), regulation of reproductive process (GO:2000241), positive regulation of growth (GO:0045927), regulation of developmental process (GO:0050793), positive regulation of signaling (GO:0023056), multicellular organism development (GO:0007275), regulation of localization (GO:0032879), organic substance metabolic process (GO:0071704), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), response to stress (GO:0006950), cellular component morphogenesis (GO:0032989), negative regulation of cellular component organization (GO:0051129), regulation of cell motility (GO:2000145), regulation of system process (GO:0044057), animal organ development (GO:0048513), neural retina development (GO:0003407), regulation of vesicle-mediated transport (GO:0060627), positive regulation of apoptotic process involved in development (GO:1904747), negative regulation of cellular response to growth factor stimulus (GO:0090288), retina development in camera-type eye (GO:0060041), negative regulation of secretion (GO:0051048), regulation of development, heterochronic (GO:0040034), cardiac septum morphogenesis (GO:0060411), regulation of anatomical structure morphogenesis (GO:0022603), secretion by cell (GO:0032940), nephron development (GO:0072006), trabecula morphogenesis (GO:0061383), negative regulation of muscle hypertrophy (GO:0014741), positive regulation of epidermis development (GO:0045684), positive regulation of nitrogen compound metabolic process (GO:0051173), positive regulation of cell differentiation (GO:0045597), appendage development (GO:0048736), organic substance biosynthetic process (GO:1901576), negative regulation of cell population proliferation (GO:0008285), protein metabolic process (GO:0019538), specification of symmetry (GO:0009799), cellular biosynthetic process (GO:0044249), response to oxygen-containing compound (GO:1901700), prostate gland epithelium morphogenesis (GO:0060740), macromolecule metabolic process (GO:0043170), positive regulation of cell motility (GO:2000147), positive regulation of biosynthetic process (GO:0009891), homeostasis of number of cells (GO:0048872), endocardial cushion formation (GO:0003272), muscle structure development (GO:0061061), regulation of cell population proliferation (GO:0042127), regulation of cell death (GO:0010941), regionalization (GO:0003002), response to nitrogen compound (GO:1901698), negative regulation of cell differentiation (GO:0045596), transport (GO:0006810), humoral immune response (GO:0006959), positive regulation of cell communication (GO:0010647), regulation of cellular metabolic process (GO:0031323), hair cycle process (GO:0022405), regulation of primary metabolic process (GO:0080090), negative regulation of signal transduction (GO:0009968), response to hypoxia (GO:0001666), regulation of viral genome replication (GO:0045069), negative regulation of cell death (GO:0060548), cell differentiation (GO:0030154), negative regulation of nervous system development (GO:0051961), system development (GO:0048731), response to oxygen levels (GO:0070482), cardiac septum development (GO:0003279), regulation of cell adhesion (GO:0030155), regulation of organ growth (GO:0046620), heart growth (GO:0060419), tube development (GO:0035295), cell morphogenesis (GO:0000902), animal organ morphogenesis (GO:0009887), cell surface receptor signaling pathway (GO:0007166), regulation of cellular component organization (GO:0051128), negative regulation of biomineral tissue development (GO:0070168), regulation of ossification (GO:0030278), positive regulation of cell population proliferation (GO:0008284), tube morphogenesis (GO:0035239), positive regulation of developmental growth (GO:0048639), negative regulation of cell communication (GO:0010648), apoptotic process involved in development (GO:1902742), axis specification (GO:0009798), retina morphogenesis in camera-type eye (GO:0060042), hair follicle morphogenesis (GO:0031069), morphogenesis of a branching epithelium (GO:0061138), positive regulation of organ growth (GO:0046622), cardiac chamber development (GO:0003205), negative regulation of cellular metabolic process (GO:0031324), cell fate commitment (GO:0045165), embryonic morphogenesis (GO:0048598), cellular response to chemical stimulus (GO:0070887), glomerulus development (GO:0032835), tissue homeostasis (GO:0001894), stem cell division (GO:0017145), hair cycle (GO:0042633), regulation of cold-induced thermogenesis (GO:0120161), developmental growth involved in morphogenesis (GO:0060560), negative regulation of photoreceptor cell differentiation (GO:0046533), regulation of signal transduction (GO:0009966), foregut morphogenesis (GO:0007440), regulation of macromolecule metabolic process (GO:0060255), reproductive structure development (GO:0048608), cellular aromatic compound metabolic process (GO:0006725), regulation of muscle adaptation (GO:0043502), positive regulation of epithelial to mesenchymal transition (GO:0010718), establishment of protein localization (GO:0045184), regulation of cellular component biogenesis (GO:0044087), regulation of apoptotic process involved in development (GO:1904748), intracellular transport (GO:0046907), negative regulation of macromolecule metabolic process (GO:0010605), muscle cell proliferation (GO:0033002), embryo development (GO:0009790), regulation of catalytic activity (GO:0050790), negative regulation of nitrogen compound metabolic process (GO:0051172), regulation of epidermis development (GO:0045682), positive regulation of macromolecule metabolic process (GO:0010604), blood vessel development (GO:0001568), heterocycle metabolic process (GO:0046483), negative regulation of molecular function (GO:0044092), establishment of localization in cell (GO:0051649), appendage morphogenesis (GO:0035107), cellular nitrogen compound metabolic process (GO:0034641), apoptotic process involved in morphogenesis (GO:0060561), angiogenesis (GO:0001525), regulation of multicellular organismal development (GO:2000026), regulation of viral transcription (GO:0046782), positive regulation of cellular metabolic process (GO:0031325), cellular response to stress (GO:0033554), epithelial cell proliferation (GO:0050673), cellular macromolecule localization (GO:0070727), negative regulation of biosynthetic process (GO:0009890), regulation of cellular response to growth factor stimulus (GO:0090287), positive regulation of cell death (GO:0010942), tissue morphogenesis (GO:0048729), programmed cell death (GO:0012501), adaptive immune response (GO:0002250), cell development (GO:0048468), prostate gland morphogenesis (GO:0060512), cardiac muscle tissue growth (GO:0055017), cell fate determination (GO:0001708), heart valve development (GO:0003170), negative regulation of ossification (GO:0030279), inflammatory response to antigenic stimulus (GO:0002437), organic cyclic compound metabolic process (GO:1901360), forebrain development (GO:0030900), hair follicle development (GO:0001942), regulation of nitrogen compound metabolic process (GO:0051171), regulation of cell differentiation (GO:0045595), cellular component organization (GO:0016043), inner ear development (GO:0048839), organic substance catabolic process (GO:1901575), positive regulation of nervous system development (GO:0051962), negative regulation of secretion by cell (GO:1903531), regulation of developmental growth (GO:0048638), endocardium development (GO:0003157), cell migration (GO:0016477), positive regulation of signal transduction (GO:0009967), regulation of secretion by cell (GO:1903530), positive regulation of viral genome replication (GO:0045070), regulation of transport (GO:0051049), organonitrogen compound metabolic process (GO:1901564), defense response (GO:0006952), response to organic substance (GO:0010033), anatomical structure homeostasis (GO:0060249), regulation of viral life cycle (GO:1903900), tissue development (GO:0009888), nucleobase-containing compound metabolic process (GO:0006139), head development (GO:0060322), regulation of cell communication (GO:0010646), regulation of biosynthetic process (GO:0009889), cardiac chamber morphogenesis (GO:0003206), heart valve morphogenesis (GO:0003179), negative regulation of cold-induced thermogenesis (GO:0120163), endoderm development (GO:0007492), regulation of hematopoietic progenitor cell differentiation (GO:1901532), nephron epithelium development (GO:0072009), cell projection organization (GO:0030030), regulation of Notch signaling pathway (GO:0008593), somatic stem cell division (GO:0048103), regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092), positive regulation of cardiac muscle cell proliferation (GO:0060045), regulation of receptor signaling pathway via STAT (GO:1904892), regulation of epithelial cell proliferation (GO:0050678), semi-lunar valve development (GO:1905314), muscle cell differentiation (GO:0042692), embryonic heart tube development (GO:0035050), cell surface receptor signaling pathway involved in heart development (GO:0061311), circulatory system development (GO:0072359), response to decreased oxygen levels (GO:0036293), positive regulation of cell migration (GO:0030335), regulation of osteoblast differentiation (GO:0045667), cell projection morphogenesis (GO:0048858), pulmonary valve morphogenesis (GO:0003184), cytokine-mediated signaling pathway (GO:0019221), negative regulation of exocytosis (GO:0045920), ventricular septum development (GO:0003281), positive regulation of Notch signaling pathway (GO:0045747), regulation of cell proliferation involved in heart morphogenesis (GO:2000136), cellular response to organic substance (GO:0071310), establishment of protein localization to organelle (GO:0072594), cell migration involved in heart development (GO:0060973), positive regulation of epithelial cell differentiation (GO:0030858), limb morphogenesis (GO:0035108), regulation of muscle cell differentiation (GO:0051147), hepaticobiliary system development (GO:0061008), skeletal muscle cell differentiation (GO:0035914), Notch signaling pathway (GO:0007219), cardiac atrium morphogenesis (GO:0003209), positive regulation of macromolecule biosynthetic process (GO:0010557), apoptotic process (GO:0006915), adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460), regulation of nucleobase-containing compound metabolic process (GO:0019219), epithelium development (GO:0060429), gland morphogenesis (GO:0022612), positive regulation of cellular biosynthetic process (GO:0031328), atrioventricular valve morphogenesis (GO:0003181), regulation of epithelial cell differentiation (GO:0030856), respiratory system development (GO:0060541), response to peptide (GO:1901652), regulation of programmed cell death (GO:0043067), protein catabolic process (GO:0030163), gland development (GO:0048732), cell differentiation involved in kidney development (GO:0061005), cardiac ventricle development (GO:0003231), morphogenesis of an epithelium (GO:0002009), positive regulation of neurogenesis (GO:0050769), skin development (GO:0043588), regulation of cell migration (GO:0030334), neuron development (GO:0048666), coronary vasculature development (GO:0060976), branching morphogenesis of an epithelial tube (GO:0048754), cardiac ventricle morphogenesis (GO:0003208), macromolecule catabolic process (GO:0009057), embryonic organ development (GO:0048568), cell morphogenesis involved in differentiation (GO:0000904), exocytosis (GO:0006887), renal tubule development (GO:0061326), nucleic acid metabolic process (GO:0090304), camera-type eye photoreceptor cell differentiation (GO:0060219), regulation of extracellular matrix organization (GO:1903053), negative regulation of cellular biosynthetic process (GO:0031327), negative regulation of Wnt signaling pathway (GO:0030178), mesenchymal cell differentiation (GO:0048762), negative regulation of cardiac muscle hypertrophy (GO:0010614), gene expression (GO:0010467), negative regulation of nucleobase-containing compound metabolic process (GO:0045934), regulation of cardiac muscle cell proliferation (GO:0060043), renal system development (GO:0072001), cardiac muscle cell proliferation (GO:0060038), reproductive system development (GO:0061458), negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101), embryonic organ morphogenesis (GO:0048562), negative regulation of hematopoietic progenitor cell differentiation (GO:1901533), positive regulation of cell development (GO:0010720), urogenital system development (GO:0001655), positive regulation of gene expression (GO:0010628), muscle organ morphogenesis (GO:0048644), positive regulation of receptor signaling pathway via STAT (GO:1904894), positive regulation of nucleobase-containing compound metabolic process (GO:0045935), regulation of extracellular matrix assembly (GO:1901201), respiratory tube development (GO:0030323), response to organonitrogen compound (GO:0010243), positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100), prostate gland development (GO:0030850), venous blood vessel development (GO:0060841), negative regulation of macromolecule biosynthetic process (GO:0010558), cardiac atrium development (GO:0003230), cardiocyte differentiation (GO:0035051), blood vessel endothelial cell differentiation (GO:0060837), regulation of epithelial to mesenchymal transition (GO:0010717), glomerulus vasculature development (GO:0072012), digestive tract development (GO:0048565), neuron differentiation (GO:0030182), cardiac cell development (GO:0055006), epithelial tube morphogenesis (GO:0060562), nitrogen compound transport (GO:0071705), embryonic digit morphogenesis (GO:0042733), regulation of macromolecule biosynthetic process (GO:0010556), cellular response to oxygen levels (GO:0071453), sensory system development (GO:0048880), vasculature development (GO:0001944), connective tissue development (GO:0061448), regulation of glial cell proliferation (GO:0060251), glial cell differentiation (GO:0010001), organic substance transport (GO:0071702), embryonic heart tube morphogenesis (GO:0003143), negative regulation of muscle cell differentiation (GO:0051148), regulation of gene expression (GO:0010468), regulation of cardiac muscle tissue growth (GO:0055021), striated muscle cell proliferation (GO:0014855), intracellular protein transport (GO:0006886), negative regulation of osteoblast differentiation (GO:0045668), epithelial cell development (GO:0002064), regulation of embryonic development (GO:0045995), heart trabecula morphogenesis (GO:0061384), epidermal cell fate specification (GO:0009957), sprouting angiogenesis (GO:0002040), heart development (GO:0007507), artery development (GO:0060840), cellular response to hypoxia (GO:0071456), positive regulation of heart growth (GO:0060421), atrioventricular valve development (GO:0003171), organonitrogen compound catabolic process (GO:1901565), epithelial cell fate commitment (GO:0072148), neuron fate commitment (GO:0048663), muscle cell development (GO:0055001), aromatic compound biosynthetic process (GO:0019438), regulation of cell development (GO:0060284), sensory organ development (GO:0007423), regulation of exocytosis (GO:0017157), secretion (GO:0046903), regulation of Wnt signaling pathway (GO:0030111), regulation of glial cell differentiation (GO:0045685), positive regulation of epithelial cell proliferation (GO:0050679), neurogenesis (GO:0022008), positive regulation of RNA metabolic process (GO:0051254), ventricular septum morphogenesis (GO:0060412), inflammatory response (GO:0006954), negative regulation of epithelial cell proliferation (GO:0050680), left/right pattern formation (GO:0060972), muscle tissue development (GO:0060537), regulation of stem cell proliferation (GO:0072091), regulation of cellular biosynthetic process (GO:0031326), regulation of cardiac muscle hypertrophy (GO:0010611), cellular nitrogen compound biosynthetic process (GO:0044271), embryonic appendage morphogenesis (GO:0035113), protein localization (GO:0008104), muscle organ development (GO:0007517), negative regulation of cell development (GO:0010721), embryo development ending in birth or egg hatching (GO:0009792), regulation of neuron differentiation (GO:0045664), macromolecule biosynthetic process (GO:0009059), organic cyclic compound biosynthetic process (GO:1901362), negative regulation of BMP signaling pathway (GO:0030514), digestive system development (GO:0055123), cell part morphogenesis (GO:0032990), sensory organ morphogenesis (GO:0090596), nuclear transport (GO:0051169), aortic valve morphogenesis (GO:0003180), regulation of BMP signaling pathway (GO:0030510), regulation of muscle system process (GO:0090257), regulation of epidermal cell differentiation (GO:0045604), brain development (GO:0007420), negative regulation of neurogenesis (GO:0050768), regulation of heart growth (GO:0060420), heart morphogenesis (GO:0003007), nervous system development (GO:0007399), epidermis development (GO:0008544), protein transport (GO:0015031), positive regulation of cardiac muscle tissue growth (GO:0055023), heterocycle biosynthetic process (GO:0018130), vasculogenesis (GO:0001570), central nervous system development (GO:0007417), negative regulation of glial cell proliferation (GO:0060253), inner ear receptor cell differentiation (GO:0060113), regulation of RNA metabolic process (GO:0051252), response to cytokine (GO:0034097), negative regulation of catalytic activity (GO:0043086), muscle tissue morphogenesis (GO:0060415), neural tube development (GO:0021915), positive regulation of programmed cell death (GO:0043068), positive regulation of epidermal cell differentiation (GO:0045606), regulation of nervous system development (GO:0051960), mesenchyme development (GO:0060485), negative regulation of neuron differentiation (GO:0045665), left/right axis specification (GO:0070986), digestive tract morphogenesis (GO:0048546), epithelial cell differentiation (GO:0030855), nucleobase-containing compound biosynthetic process (GO:0034654), regulation of biomineral tissue development (GO:0070167), determination of bilateral symmetry (GO:0009855), lung development (GO:0030324), stem cell differentiation (GO:0048863), mesenchyme morphogenesis (GO:0072132), myoblast differentiation (GO:0045445), blood vessel morphogenesis (GO:0048514), negative regulation of epithelial cell differentiation (GO:0030857), limb development (GO:0060173), regulation of secretion (GO:0051046), vesicle-mediated transport (GO:0016192), homeostasis of number of cells within a tissue (GO:0048873), negative regulation of RNA metabolic process (GO:0051253), kidney development (GO:0001822), anterior/posterior pattern specification (GO:0009952), regulation of apoptotic process (GO:0042981), negative regulation of gliogenesis (GO:0014014), striated muscle tissue development (GO:0014706), ear development (GO:0043583), cardiac left ventricle morphogenesis (GO:0003214), skeletal muscle tissue development (GO:0007519), ventricular trabecula myocardium morphogenesis (GO:0003222), regulation of oligodendrocyte differentiation (GO:0048713), liver development (GO:0001889), positive regulation of RNA biosynthetic process (GO:1902680), artery morphogenesis (GO:0048844), cardiac epithelial to mesenchymal transition (GO:0060317), nucleocytoplasmic transport (GO:0006913), regulation of astrocyte differentiation (GO:0048710), response to interleukin-17 (GO:0097396), positive regulation of BMP signaling pathway (GO:0030513), cardiac muscle tissue development (GO:0048738), photoreceptor cell differentiation (GO:0046530), kidney epithelium development (GO:0072073), endocardial cushion morphogenesis (GO:0003203), columnar/cuboidal epithelial cell differentiation (GO:0002065), gliogenesis (GO:0042063), neuron projection development (GO:0031175), endothelium development (GO:0003158), epidermal cell differentiation (GO:0009913), regulation of keratinocyte differentiation (GO:0045616), nucleic acid-templated transcription (GO:0097659), pericardium development (GO:0060039), mechanoreceptor differentiation (GO:0042490), determination of left/right symmetry (GO:0007368), pulmonary valve development (GO:0003177), eye morphogenesis (GO:0048592), hindlimb morphogenesis (GO:0035137), smooth muscle cell differentiation (GO:0051145), oligodendrocyte differentiation (GO:0048709), endocardial cushion development (GO:0003197), epidermis morphogenesis (GO:0048730), negative regulation of regulated secretory pathway (GO:1903306), regulation of neurogenesis (GO:0050767), negative regulation of canonical Wnt signaling pathway (GO:0090090), regulation of canonical Wnt signaling pathway (GO:0060828), inner ear auditory receptor cell differentiation (GO:0042491), cell morphogenesis involved in neuron differentiation (GO:0048667), skeletal muscle organ development (GO:0060538), regulation of striated muscle cell differentiation (GO:0051153), positive regulation of gliogenesis (GO:0014015), positive regulation of glial cell differentiation (GO:0045687)
Cellular Component: cellular_component (GO:0005575), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), membrane (GO:0016020), membrane-enclosed lumen (GO:0031974), cytosol (GO:0005829), cell surface (GO:0009986), cell periphery (GO:0071944), cell junction (GO:0030054), organelle subcompartment (GO:0031984), apical part of cell (GO:0045177), cytoplasm (GO:0005737), endomembrane system (GO:0012505), nucleoplasm (GO:0005654), extracellular region (GO:0005576), organelle membrane (GO:0031090), cytoplasmic vesicle (GO:0031410), intracellular organelle (GO:0043229), apical plasma membrane (GO:0016324), endoplasmic reticulum subcompartment (GO:0098827), nuclear outer membrane-endoplasmic reticulum membrane network (GO:0042175), Golgi apparatus (GO:0005794), plasma membrane region (GO:0098590), organelle lumen (GO:0043233), endoplasmic reticulum (GO:0005783), anchoring junction (GO:0070161), membrane-bounded organelle (GO:0043227), plasma membrane (GO:0005886), intracellular membrane-bounded organelle (GO:0043231), bounding membrane of organelle (GO:0098588), endoplasmic reticulum membrane (GO:0005789), vesicle (GO:0031982), intracellular organelle lumen (GO:0070013), cell-cell junction (GO:0005911), Golgi membrane (GO:0000139), intracellular vesicle (GO:0097708), nucleus (GO:0005634), nuclear lumen (GO:0031981), adherens junction (GO:0005912)
Generated by BioReason
Exported on March 22, 2026 at 01:24 AM
Organism: Mus musculus
Sequence:
MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGGVCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDIPPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYGHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGM
I begin with the InterPro architecture. A broad family signature, IPR008297 (Notch family, residues 5–2000), blankets essentially the entire polypeptide, immediately placing the protein within the Notch receptor lineage. The N-terminal half is densely packed with extracellular EGF modules: IPR000742 (EGF-like domain, residues 20–1426), IPR001881 (EGF-like calcium-binding domain, residues 59–1384), IPR018097 (EGF-like calcium-binding conserved site, residues 178–1253), and IPR049883 (NOTCH1, EGF-like calcium-binding domain, residues 178–900). These repeated EGF repeats and their Ca2+-binding motifs generate a rigid, cysteine-rich scaffold that enforces precise intermolecular contacts and mechanosensing at the cell surface. This extracellular region is further supported by IPR009030 (Growth factor receptor cysteine-rich domain superfamily, residues 288–1311), emphasizing a disulfide-stabilized receptor fold, and by IPR000152 (EGF-type aspartate/asparagine hydroxylation site, residues 195–1255) and IPR013032 (EGF-like conserved site, residues 344–1374), which together indicate extensive post-translational hydroxylation and glycosylation typical of secreted or surface-exposed EGF arrays. This extracellular EGF architecture causes high-affinity, Ca2+-tunable binding and force-dependent activation characteristic of Notch receptors.
Proceeding into the intracellular signaling core, a series of Notch-specific modules appears: IPR022362 (Neurogenic locus notch homolog protein 1 family, residues 1426–1714) leads into IPR000800 (Notch domain, residues 1442–1571), IPR035993 (Notch-like domain superfamily, residues 1448–1561), IPR010660 (Notch, NOD domain, residues 1566–1622), and IPR011656 (Notch, NODP domain, residues 1660–1722). This ordered block encodes the canonical heterodimerization and negative regulatory apparatus of Notch receptors: the NOD/NODP cassette forms the negative regulatory region that clamps the receptor’s intracellular tail until activating endocytosis and mechanical tension unlock it. Downstream, IPR036770 (Ankyrin repeat-containing domain superfamily, residues 1858–2000) and IPR002110 (Ankyrin repeat, residues 1870–1980) specify a C-terminal ankyrin-repeat platform that binds transcriptional co-regulators. The combined evidence—extracellular EGF arrays, followed by the NOD/NODP switch and a C-terminal ankyrin scaffold—defines a single-pass type I receptor that signals by proteolytic activation and intracellular complex assembly.
From this architecture, the molecular function resolves as follows. The extracellular EGF array and calcium-binding sites enforce ligand-gated activation and support protein-protein interactions at the surface; the intracellular ankyrin repeats and the activated signaling core drive assembly of transcriptional effector complexes. This causally establishes protein binding (GO:0005515) as the operative activity: the receptor binds extracellular ligands and intracellular partners to translate a surface cue into transcriptional control.
The biological process follows from this signaling logic. Notch receptors govern binary fate decisions by inducing gene expression programs that restrain or promote differentiation. The EGF-driven activation and ankyrin-mediated transcriptional assembly together enforce control of lineage bifurcation and timing, aligning with cell fate determination (GO:0001708). This process-level inference arises directly from the coupling of an extracellular ligand-gated module to an intracellular transcriptional hub.
Cellular location is dictated by the single-pass type I topology and the extracellular EGF region. Such receptors are synthesized into the secretory pathway and displayed at the cell surface, where they function as membrane-bound signal transducers. This places the protein at the plasma membrane/cell surface and classifies it as an integral component of membrane, matching a single-pass type I membrane protein.
Mechanistically, the extracellular EGF platform binds Delta/Serrate/Jagged-type ligands on neighboring cells; endocytosis and Ca2+-stabilized EGF architecture transmit mechanical force that unlocks the NOD/NODP switch, triggering intramembrane proteolysis and liberation of the intracellular domain. The released intracellular fragment then engages the ankyrin-repeat platform to recruit CSL/RBPJ transcription complexes and coactivators, thereby rewiring gene expression to bias cell fate. Likely interaction partners include membrane ligands and extracellular modulators that deliver activation cues, as well as intracellular DNA-binding and co-regulatory assemblies that implement the transcriptional output.
A single-pass cell-surface receptor that uses a long calcium-stabilized EGF repeat array to sense extracellular cues and trigger intramembrane signaling. Upon ligand engagement and endocytic activation, a built-in regulatory switch releases the intracellular tail, which then assembles transcriptional effector complexes via ankyrin repeats to reprogram gene expression. This signaling cascade governs binary fate decisions and timing of differentiation by coupling extracellular recognition to intracellular transcriptional control at the plasma membrane.
Functions as a receptor for several membrane-bound ligands that are presented on the surface of adjacent cells. Activates transcription factors that are involved in lineage specification. May play a role in cell-fate determination (By similarity).
IPR008297, family) — residues 5-2000IPR000742, domain) — residues 20-1426IPR001881, domain) — residues 59-1384IPR018097, conserved_site) — residues 178-1253IPR049883, domain) — residues 178-900IPR000152, ptm) — residues 195-1255IPR009030, homologous_superfamily) — residues 288-1311IPR013032, conserved_site) — residues 344-1374IPR022362, family) — residues 1426-1714IPR000800, domain) — residues 1442-1571IPR035993, homologous_superfamily) — residues 1448-1561IPR010660, domain) — residues 1566-1622IPR011656, domain) — residues 1660-1722IPR036770, homologous_superfamily) — residues 1858-2000IPR002110, repeat) — residues 1870-1980Molecular Function: molecular_function (GO:0003674), molecular function regulator activity (GO:0098772), binding (GO:0005488), transcription regulator activity (GO:0140110), enzyme regulator activity (GO:0030234), molecular function activator activity (GO:0140677), heterocyclic compound binding (GO:1901363), chromatin binding (GO:0003682), organic cyclic compound binding (GO:0097159), transcription coregulator activity (GO:0003712), protein binding (GO:0005515), molecular function inhibitor activity (GO:0140678), nucleic acid binding (GO:0003676), signaling receptor binding (GO:0005102), chromatin DNA binding (GO:0031490), enzyme binding (GO:0019899), enzyme inhibitor activity (GO:0004857), transcription coactivator activity (GO:0003713), Notch binding (GO:0005112), DNA binding (GO:0003677)
Biological Process: biological_process (GO:0008150), biological regulation (GO:0065007), response to stimulus (GO:0050896), reproductive process (GO:0022414), regulation of biological process (GO:0050789), reproduction (GO:0000003), multicellular organismal process (GO:0032501), metabolic process (GO:0008152), homeostatic process (GO:0042592), immune system process (GO:0002376), localization (GO:0051179), signaling (GO:0023052), growth (GO:0040007), negative regulation of biological process (GO:0048519), positive regulation of biological process (GO:0048518), developmental process (GO:0032502), cellular process (GO:0009987), anatomical structure development (GO:0048856), negative regulation of signaling (GO:0023057), cell division (GO:0051301), developmental process involved in reproduction (GO:0003006), anatomical structure formation involved in morphogenesis (GO:0048646), multicellular organismal-level homeostasis (GO:0048871), regulation of response to stimulus (GO:0048583), negative regulation of cellular process (GO:0048523), biosynthetic process (GO:0009058), positive regulation of viral process (GO:0048524), establishment of localization (GO:0051234), catabolic process (GO:0009056), macromolecule localization (GO:0033036), developmental growth (GO:0048589), cell population proliferation (GO:0008283), nitrogen compound metabolic process (GO:0006807), negative regulation of multicellular organismal process (GO:0051241), cell death (GO:0008219), positive regulation of locomotion (GO:0040017), regulation of signaling (GO:0023051), negative regulation of developmental process (GO:0051093), signal transduction (GO:0007165), negative regulation of transport (GO:0051051), regulation of viral process (GO:0050792), primary metabolic process (GO:0044238), morphogenesis of a branching structure (GO:0001763), positive regulation of developmental process (GO:0051094), negative regulation of response to stimulus (GO:0048585), regulation of growth (GO:0040008), cellular localization (GO:0051641), immune response (GO:0006955), positive regulation of multicellular organismal process (GO:0051240), molting cycle (GO:0042303), pattern specification process (GO:0007389), cellular component organization or biogenesis (GO:0071840), regulation of multicellular organismal process (GO:0051239), negative regulation of metabolic process (GO:0009892), regulation of cellular process (GO:0050794), cellular response to stimulus (GO:0051716), regulation of locomotion (GO:0040012), cellular developmental process (GO:0048869), response to abiotic stimulus (GO:0009628), organ growth (GO:0035265), positive regulation of response to stimulus (GO:0048584), regulation of metabolic process (GO:0019222), molting cycle process (GO:0022404), regulation of molecular function (GO:0065009), export from cell (GO:0140352), cell communication (GO:0007154), positive regulation of cellular process (GO:0048522), anatomical structure morphogenesis (GO:0009653), cell motility (GO:0048870), response to chemical (GO:0042221), regulation of reproductive process (GO:2000241), positive regulation of growth (GO:0045927), regulation of developmental process (GO:0050793), positive regulation of signaling (GO:0023056), multicellular organism development (GO:0007275), regulation of localization (GO:0032879), organic substance metabolic process (GO:0071704), cellular metabolic process (GO:0044237), positive regulation of metabolic process (GO:0009893), response to stress (GO:0006950), cellular component morphogenesis (GO:0032989), negative regulation of cellular component organization (GO:0051129), regulation of cell motility (GO:2000145), regulation of system process (GO:0044057), animal organ development (GO:0048513), neural retina development (GO:0003407), regulation of vesicle-mediated transport (GO:0060627), positive regulation of apoptotic process involved in development (GO:1904747), negative regulation of cellular response to growth factor stimulus (GO:0090288), retina development in camera-type eye (GO:0060041), negative regulation of secretion (GO:0051048), regulation of development, heterochronic (GO:0040034), cardiac septum morphogenesis (GO:0060411), regulation of anatomical structure morphogenesis (GO:0022603), secretion by cell (GO:0032940), nephron development (GO:0072006), trabecula morphogenesis (GO:0061383), negative regulation of muscle hypertrophy (GO:0014741), positive regulation of epidermis development (GO:0045684), positive regulation of nitrogen compound metabolic process (GO:0051173), positive regulation of cell differentiation (GO:0045597), appendage development (GO:0048736), organic substance biosynthetic process (GO:1901576), negative regulation of cell population proliferation (GO:0008285), protein metabolic process (GO:0019538), specification of symmetry (GO:0009799), cellular biosynthetic process (GO:0044249), response to oxygen-containing compound (GO:1901700), prostate gland epithelium morphogenesis (GO:0060740), macromolecule metabolic process (GO:0043170), positive regulation of cell motility (GO:2000147), positive regulation of biosynthetic process (GO:0009891), homeostasis of number of cells (GO:0048872), endocardial cushion formation (GO:0003272), muscle structure development (GO:0061061), regulation of cell population proliferation (GO:0042127), regulation of cell death (GO:0010941), regionalization (GO:0003002), response to nitrogen compound (GO:1901698), negative regulation of cell differentiation (GO:0045596), transport (GO:0006810), humoral immune response (GO:0006959), positive regulation of cell communication (GO:0010647), regulation of cellular metabolic process (GO:0031323), hair cycle process (GO:0022405), regulation of primary metabolic process (GO:0080090), negative regulation of signal transduction (GO:0009968), response to hypoxia (GO:0001666), regulation of viral genome replication (GO:0045069), negative regulation of cell death (GO:0060548), cell differentiation (GO:0030154), negative regulation of nervous system development (GO:0051961), system development (GO:0048731), response to oxygen levels (GO:0070482), cardiac septum development (GO:0003279), regulation of cell adhesion (GO:0030155), regulation of organ growth (GO:0046620), heart growth (GO:0060419), tube development (GO:0035295), cell morphogenesis (GO:0000902), animal organ morphogenesis (GO:0009887), cell surface receptor signaling pathway (GO:0007166), regulation of cellular component organization (GO:0051128), negative regulation of biomineral tissue development (GO:0070168), regulation of ossification (GO:0030278), positive regulation of cell population proliferation (GO:0008284), tube morphogenesis (GO:0035239), positive regulation of developmental growth (GO:0048639), negative regulation of cell communication (GO:0010648), apoptotic process involved in development (GO:1902742), axis specification (GO:0009798), retina morphogenesis in camera-type eye (GO:0060042), hair follicle morphogenesis (GO:0031069), morphogenesis of a branching epithelium (GO:0061138), positive regulation of organ growth (GO:0046622), cardiac chamber development (GO:0003205), negative regulation of cellular metabolic process (GO:0031324), cell fate commitment (GO:0045165), embryonic morphogenesis (GO:0048598), cellular response to chemical stimulus (GO:0070887), glomerulus development (GO:0032835), tissue homeostasis (GO:0001894), stem cell division (GO:0017145), hair cycle (GO:0042633), regulation of cold-induced thermogenesis (GO:0120161), developmental growth involved in morphogenesis (GO:0060560), negative regulation of photoreceptor cell differentiation (GO:0046533), regulation of signal transduction (GO:0009966), foregut morphogenesis (GO:0007440), regulation of macromolecule metabolic process (GO:0060255), reproductive structure development (GO:0048608), cellular aromatic compound metabolic process (GO:0006725), regulation of muscle adaptation (GO:0043502), positive regulation of epithelial to mesenchymal transition (GO:0010718), establishment of protein localization (GO:0045184), regulation of cellular component biogenesis (GO:0044087), regulation of apoptotic process involved in development (GO:1904748), intracellular transport (GO:0046907), negative regulation of macromolecule metabolic process (GO:0010605), muscle cell proliferation (GO:0033002), embryo development (GO:0009790), regulation of catalytic activity (GO:0050790), negative regulation of nitrogen compound metabolic process (GO:0051172), regulation of epidermis development (GO:0045682), positive regulation of macromolecule metabolic process (GO:0010604), blood vessel development (GO:0001568), heterocycle metabolic process (GO:0046483), negative regulation of molecular function (GO:0044092), establishment of localization in cell (GO:0051649), appendage morphogenesis (GO:0035107), cellular nitrogen compound metabolic process (GO:0034641), apoptotic process involved in morphogenesis (GO:0060561), angiogenesis (GO:0001525), regulation of multicellular organismal development (GO:2000026), regulation of viral transcription (GO:0046782), positive regulation of cellular metabolic process (GO:0031325), cellular response to stress (GO:0033554), epithelial cell proliferation (GO:0050673), cellular macromolecule localization (GO:0070727), negative regulation of biosynthetic process (GO:0009890), regulation of cellular response to growth factor stimulus (GO:0090287), positive regulation of cell death (GO:0010942), tissue morphogenesis (GO:0048729), programmed cell death (GO:0012501), adaptive immune response (GO:0002250), cell development (GO:0048468), prostate gland morphogenesis (GO:0060512), cardiac muscle tissue growth (GO:0055017), cell fate determination (GO:0001708), heart valve development (GO:0003170), negative regulation of ossification (GO:0030279), inflammatory response to antigenic stimulus (GO:0002437), organic cyclic compound metabolic process (GO:1901360), forebrain development (GO:0030900), hair follicle development (GO:0001942), regulation of nitrogen compound metabolic process (GO:0051171), regulation of cell differentiation (GO:0045595), cellular component organization (GO:0016043), inner ear development (GO:0048839), organic substance catabolic process (GO:1901575), positive regulation of nervous system development (GO:0051962), negative regulation of secretion by cell (GO:1903531), regulation of developmental growth (GO:0048638), endocardium development (GO:0003157), cell migration (GO:0016477), positive regulation of signal transduction (GO:0009967), regulation of secretion by cell (GO:1903530), positive regulation of viral genome replication (GO:0045070), regulation of transport (GO:0051049), organonitrogen compound metabolic process (GO:1901564), defense response (GO:0006952), response to organic substance (GO:0010033), anatomical structure homeostasis (GO:0060249), regulation of viral life cycle (GO:1903900), tissue development (GO:0009888), nucleobase-containing compound metabolic process (GO:0006139), head development (GO:0060322), regulation of cell communication (GO:0010646), regulation of biosynthetic process (GO:0009889), cardiac chamber morphogenesis (GO:0003206), heart valve morphogenesis (GO:0003179), negative regulation of cold-induced thermogenesis (GO:0120163), endoderm development (GO:0007492), regulation of hematopoietic progenitor cell differentiation (GO:1901532), nephron epithelium development (GO:0072009), cell projection organization (GO:0030030), regulation of Notch signaling pathway (GO:0008593), somatic stem cell division (GO:0048103), regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092), positive regulation of cardiac muscle cell proliferation (GO:0060045), regulation of receptor signaling pathway via STAT (GO:1904892), regulation of epithelial cell proliferation (GO:0050678), semi-lunar valve development (GO:1905314), muscle cell differentiation (GO:0042692), embryonic heart tube development (GO:0035050), cell surface receptor signaling pathway involved in heart development (GO:0061311), circulatory system development (GO:0072359), response to decreased oxygen levels (GO:0036293), positive regulation of cell migration (GO:0030335), regulation of osteoblast differentiation (GO:0045667), cell projection morphogenesis (GO:0048858), pulmonary valve morphogenesis (GO:0003184), cytokine-mediated signaling pathway (GO:0019221), negative regulation of exocytosis (GO:0045920), ventricular septum development (GO:0003281), positive regulation of Notch signaling pathway (GO:0045747), regulation of cell proliferation involved in heart morphogenesis (GO:2000136), cellular response to organic substance (GO:0071310), establishment of protein localization to organelle (GO:0072594), cell migration involved in heart development (GO:0060973), positive regulation of epithelial cell differentiation (GO:0030858), limb morphogenesis (GO:0035108), regulation of muscle cell differentiation (GO:0051147), hepaticobiliary system development (GO:0061008), skeletal muscle cell differentiation (GO:0035914), Notch signaling pathway (GO:0007219), cardiac atrium morphogenesis (GO:0003209), positive regulation of macromolecule biosynthetic process (GO:0010557), apoptotic process (GO:0006915), adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460), regulation of nucleobase-containing compound metabolic process (GO:0019219), epithelium development (GO:0060429), gland morphogenesis (GO:0022612), positive regulation of cellular biosynthetic process (GO:0031328), atrioventricular valve morphogenesis (GO:0003181), regulation of epithelial cell differentiation (GO:0030856), respiratory system development (GO:0060541), response to peptide (GO:1901652), regulation of programmed cell death (GO:0043067), protein catabolic process (GO:0030163), gland development (GO:0048732), cell differentiation involved in kidney development (GO:0061005), cardiac ventricle development (GO:0003231), morphogenesis of an epithelium (GO:0002009), positive regulation of neurogenesis (GO:0050769), skin development (GO:0043588), regulation of cell migration (GO:0030334), neuron development (GO:0048666), coronary vasculature development (GO:0060976), branching morphogenesis of an epithelial tube (GO:0048754), cardiac ventricle morphogenesis (GO:0003208), macromolecule catabolic process (GO:0009057), embryonic organ development (GO:0048568), cell morphogenesis involved in differentiation (GO:0000904), exocytosis (GO:0006887), renal tubule development (GO:0061326), nucleic acid metabolic process (GO:0090304), camera-type eye photoreceptor cell differentiation (GO:0060219), regulation of extracellular matrix organization (GO:1903053), negative regulation of cellular biosynthetic process (GO:0031327), negative regulation of Wnt signaling pathway (GO:0030178), mesenchymal cell differentiation (GO:0048762), negative regulation of cardiac muscle hypertrophy (GO:0010614), gene expression (GO:0010467), negative regulation of nucleobase-containing compound metabolic process (GO:0045934), regulation of cardiac muscle cell proliferation (GO:0060043), renal system development (GO:0072001), cardiac muscle cell proliferation (GO:0060038), reproductive system development (GO:0061458), negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101), embryonic organ morphogenesis (GO:0048562), negative regulation of hematopoietic progenitor cell differentiation (GO:1901533), positive regulation of cell development (GO:0010720), urogenital system development (GO:0001655), positive regulation of gene expression (GO:0010628), muscle organ morphogenesis (GO:0048644), positive regulation of receptor signaling pathway via STAT (GO:1904894), positive regulation of nucleobase-containing compound metabolic process (GO:0045935), regulation of extracellular matrix assembly (GO:1901201), respiratory tube development (GO:0030323), response to organonitrogen compound (GO:0010243), positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100), prostate gland development (GO:0030850), venous blood vessel development (GO:0060841), negative regulation of macromolecule biosynthetic process (GO:0010558), cardiac atrium development (GO:0003230), cardiocyte differentiation (GO:0035051), blood vessel endothelial cell differentiation (GO:0060837), regulation of epithelial to mesenchymal transition (GO:0010717), glomerulus vasculature development (GO:0072012), digestive tract development (GO:0048565), neuron differentiation (GO:0030182), cardiac cell development (GO:0055006), epithelial tube morphogenesis (GO:0060562), nitrogen compound transport (GO:0071705), embryonic digit morphogenesis (GO:0042733), regulation of macromolecule biosynthetic process (GO:0010556), cellular response to oxygen levels (GO:0071453), sensory system development (GO:0048880), vasculature development (GO:0001944), connective tissue development (GO:0061448), regulation of glial cell proliferation (GO:0060251), glial cell differentiation (GO:0010001), organic substance transport (GO:0071702), embryonic heart tube morphogenesis (GO:0003143), negative regulation of muscle cell differentiation (GO:0051148), regulation of gene expression (GO:0010468), regulation of cardiac muscle tissue growth (GO:0055021), striated muscle cell proliferation (GO:0014855), intracellular protein transport (GO:0006886), negative regulation of osteoblast differentiation (GO:0045668), epithelial cell development (GO:0002064), regulation of embryonic development (GO:0045995), heart trabecula morphogenesis (GO:0061384), epidermal cell fate specification (GO:0009957), sprouting angiogenesis (GO:0002040), heart development (GO:0007507), artery development (GO:0060840), cellular response to hypoxia (GO:0071456), positive regulation of heart growth (GO:0060421), atrioventricular valve development (GO:0003171), organonitrogen compound catabolic process (GO:1901565), epithelial cell fate commitment (GO:0072148), neuron fate commitment (GO:0048663), muscle cell development (GO:0055001), aromatic compound biosynthetic process (GO:0019438), regulation of cell development (GO:0060284), sensory organ development (GO:0007423), regulation of exocytosis (GO:0017157), secretion (GO:0046903), regulation of Wnt signaling pathway (GO:0030111), regulation of glial cell differentiation (GO:0045685), positive regulation of epithelial cell proliferation (GO:0050679), neurogenesis (GO:0022008), positive regulation of RNA metabolic process (GO:0051254), ventricular septum morphogenesis (GO:0060412), inflammatory response (GO:0006954), negative regulation of epithelial cell proliferation (GO:0050680), left/right pattern formation (GO:0060972), muscle tissue development (GO:0060537), regulation of stem cell proliferation (GO:0072091), regulation of cellular biosynthetic process (GO:0031326), regulation of cardiac muscle hypertrophy (GO:0010611), cellular nitrogen compound biosynthetic process (GO:0044271), embryonic appendage morphogenesis (GO:0035113), protein localization (GO:0008104), muscle organ development (GO:0007517), negative regulation of cell development (GO:0010721), embryo development ending in birth or egg hatching (GO:0009792), regulation of neuron differentiation (GO:0045664), macromolecule biosynthetic process (GO:0009059), organic cyclic compound biosynthetic process (GO:1901362), negative regulation of BMP signaling pathway (GO:0030514), digestive system development (GO:0055123), cell part morphogenesis (GO:0032990), sensory organ morphogenesis (GO:0090596), nuclear transport (GO:0051169), aortic valve morphogenesis (GO:0003180), regulation of BMP signaling pathway (GO:0030510), regulation of muscle system process (GO:0090257), regulation of epidermal cell differentiation (GO:0045604), brain development (GO:0007420), negative regulation of neurogenesis (GO:0050768), regulation of heart growth (GO:0060420), heart morphogenesis (GO:0003007), nervous system development (GO:0007399), epidermis development (GO:0008544), protein transport (GO:0015031), positive regulation of cardiac muscle tissue growth (GO:0055023), heterocycle biosynthetic process (GO:0018130), vasculogenesis (GO:0001570), central nervous system development (GO:0007417), negative regulation of glial cell proliferation (GO:0060253), inner ear receptor cell differentiation (GO:0060113), regulation of RNA metabolic process (GO:0051252), response to cytokine (GO:0034097), negative regulation of catalytic activity (GO:0043086), muscle tissue morphogenesis (GO:0060415), neural tube development (GO:0021915), positive regulation of programmed cell death (GO:0043068), positive regulation of epidermal cell differentiation (GO:0045606), regulation of nervous system development (GO:0051960), mesenchyme development (GO:0060485), negative regulation of neuron differentiation (GO:0045665), left/right axis specification (GO:0070986), digestive tract morphogenesis (GO:0048546), epithelial cell differentiation (GO:0030855), nucleobase-containing compound biosynthetic process (GO:0034654), regulation of biomineral tissue development (GO:0070167), determination of bilateral symmetry (GO:0009855), lung development (GO:0030324), stem cell differentiation (GO:0048863), mesenchyme morphogenesis (GO:0072132), myoblast differentiation (GO:0045445), blood vessel morphogenesis (GO:0048514), negative regulation of epithelial cell differentiation (GO:0030857), limb development (GO:0060173), regulation of secretion (GO:0051046), vesicle-mediated transport (GO:0016192), homeostasis of number of cells within a tissue (GO:0048873), negative regulation of RNA metabolic process (GO:0051253), kidney development (GO:0001822), anterior/posterior pattern specification (GO:0009952), regulation of apoptotic process (GO:0042981), negative regulation of gliogenesis (GO:0014014), striated muscle tissue development (GO:0014706), ear development (GO:0043583), cardiac left ventricle morphogenesis (GO:0003214), skeletal muscle tissue development (GO:0007519), ventricular trabecula myocardium morphogenesis (GO:0003222), regulation of oligodendrocyte differentiation (GO:0048713), liver development (GO:0001889), positive regulation of RNA biosynthetic process (GO:1902680), artery morphogenesis (GO:0048844), cardiac epithelial to mesenchymal transition (GO:0060317), nucleocytoplasmic transport (GO:0006913), regulation of astrocyte differentiation (GO:0048710), response to interleukin-17 (GO:0097396), positive regulation of BMP signaling pathway (GO:0030513), cardiac muscle tissue development (GO:0048738), photoreceptor cell differentiation (GO:0046530), kidney epithelium development (GO:0072073), endocardial cushion morphogenesis (GO:0003203), columnar/cuboidal epithelial cell differentiation (GO:0002065), gliogenesis (GO:0042063), neuron projection development (GO:0031175), endothelium development (GO:0003158), epidermal cell differentiation (GO:0009913), regulation of keratinocyte differentiation (GO:0045616), nucleic acid-templated transcription (GO:0097659), pericardium development (GO:0060039), mechanoreceptor differentiation (GO:0042490), determination of left/right symmetry (GO:0007368), pulmonary valve development (GO:0003177), eye morphogenesis (GO:0048592), hindlimb morphogenesis (GO:0035137), smooth muscle cell differentiation (GO:0051145), oligodendrocyte differentiation (GO:0048709), endocardial cushion development (GO:0003197), epidermis morphogenesis (GO:0048730), negative regulation of regulated secretory pathway (GO:1903306), regulation of neurogenesis (GO:0050767), negative regulation of canonical Wnt signaling pathway (GO:0090090), regulation of canonical Wnt signaling pathway (GO:0060828), inner ear auditory receptor cell differentiation (GO:0042491), cell morphogenesis involved in neuron differentiation (GO:0048667), skeletal muscle organ development (GO:0060538), regulation of striated muscle cell differentiation (GO:0051153), positive regulation of gliogenesis (GO:0014015), positive regulation of glial cell differentiation (GO:0045687)
Cellular Component: cellular_component (GO:0005575), cellular anatomical entity (GO:0110165), intracellular anatomical structure (GO:0005622), organelle (GO:0043226), membrane (GO:0016020), membrane-enclosed lumen (GO:0031974), cytosol (GO:0005829), cell surface (GO:0009986), cell periphery (GO:0071944), cell junction (GO:0030054), organelle subcompartment (GO:0031984), apical part of cell (GO:0045177), cytoplasm (GO:0005737), endomembrane system (GO:0012505), nucleoplasm (GO:0005654), extracellular region (GO:0005576), organelle membrane (GO:0031090), cytoplasmic vesicle (GO:0031410), intracellular organelle (GO:0043229), apical plasma membrane (GO:0016324), endoplasmic reticulum subcompartment (GO:0098827), nuclear outer membrane-endoplasmic reticulum membrane network (GO:0042175), Golgi apparatus (GO:0005794), plasma membrane region (GO:0098590), organelle lumen (GO:0043233), endoplasmic reticulum (GO:0005783), anchoring junction (GO:0070161), membrane-bounded organelle (GO:0043227), plasma membrane (GO:0005886), intracellular membrane-bounded organelle (GO:0043231), bounding membrane of organelle (GO:0098588), endoplasmic reticulum membrane (GO:0005789), vesicle (GO:0031982), intracellular organelle lumen (GO:0070013), cell-cell junction (GO:0005911), Golgi membrane (GO:0000139), intracellular vesicle (GO:0097708), nucleus (GO:0005634), nuclear lumen (GO:0031981), adherens junction (GO:0005912)
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template_file: templates/gene_research_go_focused.md
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organism: mouse
gene_id: Notch1
gene_symbol: Notch1
uniprot_accession: Q01705
protein_description: 'RecName: Full=Neurogenic locus notch homolog protein 1; Short=Notch
1; AltName: Full=Motch A {ECO:0000303|PubMed:8440332}; AltName: Full=mT14; AltName:
Full=p300; Contains: RecName: Full=Notch 1 extracellular truncation {ECO:0000303|PubMed:10882062};
Short=NEXT {ECO:0000303|PubMed:10882062}; Contains: RecName: Full=Notch 1 intracellular
domain; Short=NICD; Flags: Precursor;'
gene_info: Name=Notch1; Synonyms=Motch {ECO:0000303|PubMed:8440332};
organism_full: Mus musculus (Mouse).
protein_family: Belongs to the NOTCH family. .
protein_domains: Ankyrin_rpt. (IPR002110); Ankyrin_rpt-contain_sf. (IPR036770);
EGF. (IPR000742); EGF-like_Ca-bd_dom. (IPR001881); EGF-like_CS. (IPR013032)
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BEFORE YOU BEGIN RESEARCH: You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.
DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE. Instead:
- State clearly: "The gene symbol 'Notch1' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information
Please provide a comprehensive research report on the gene Notch1 (gene ID: Notch1, UniProt: Q01705) in mouse.
The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.
You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.
We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.
We are interested in where in or outside the cell the gene product carries out its function.
We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.
Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
Notch1 (Neurogenic locus notch homolog 1) is a single-pass transmembrane receptor in the mouse, encoded by the Notch1 gene (UniProt Q01705). It belongs to the highly conserved Notch family of receptors (Notch1–4 in mammals) that mediate cell–cell communication and cell fate decisions (www.nature.com) (www.nature.com). Notch1 was originally identified by homology to Drosophila Notch (a “neurogenic” gene controlling nervous system development) and shares the fundamental role of regulating how cells differentiate during development and homeostasis (www.nature.com). In essence, Notch1 functions as a ligand-activated signaling receptor: when activated by neighboring cells, it directly influences gene transcription in the nucleus, thereby altering cell behavior. This pathway is crucial for many developmental processes and continues to operate throughout the lifespan, with roles in maintaining adult tissue structure and responding to injury (www.nature.com). Consistent with its broad importance, Notch signaling (and Notch1 in particular) has been linked to numerous human diseases, including developmental disorders and cancers (www.nature.com).
Structure and Processing: The Notch1 protein is produced as a large precursor (~2530 amino acids) that undergoes proteolytic processing and contains several defined domains important for its function. The extracellular region of mouse Notch1 features 36 EGF-like repeats (epidermal growth factor–like domains) which facilitate ligand binding (pmc.ncbi.nlm.nih.gov). Within these repeats, a specific segment (around EGF repeats 11–12) is critical for recognizing Notch ligands (such as Delta-like and Jagged family proteins) (pmc.ncbi.nlm.nih.gov). Adjacent to the EGF repeats is the negative regulatory region (NRR), composed of three cysteine-rich LIN-12/Notch repeats (LNRs) and a heterodimerization (HD) domain (pmc.ncbi.nlm.nih.gov). In the Golgi apparatus, the nascent Notch1 precursor is cleaved at the HD domain by a furin-like convertase (this is called the S1 cleavage), separating the protein into an N-terminal extracellular subunit and a C-terminal transmembrane subunit that remain non-covalently associated (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This processing yields the mature heterodimeric Notch1 receptor that is transported to the cell surface (pmc.ncbi.nlm.nih.gov). The LNR–HD region keeps the receptor in an autoinhibited conformation, preventing signaling in the absence of ligand (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).
Notch1 is activated through direct cell–cell contact. When a Notch ligand (e.g. DLL1, DLL4, JAG1, or JAG2 on a neighboring cell) binds to the Notch1 extracellular domain, it induces a conformational change and “pulling” force that exposes the receptor’s cleavage site in the HD domain (pmc.ncbi.nlm.nih.gov). This leads to the second proteolytic cut (the S2 cleavage) by ADAM-family metalloproteases at the cell surface (pmc.ncbi.nlm.nih.gov). After this ligand-triggered S2 cleavage, the remaining membrane-tethered fragment of Notch1 – called NEXT (Notch extracellular truncation) – is rapidly cleaved within its transmembrane segment by the γ-secretase complex (S3 cleavage) (pmc.ncbi.nlm.nih.gov). The γ-secretase enzyme (a multi-subunit protease complex including Presenilin) releases the Notch1 intracellular domain (NICD) from the membrane (pmc.ncbi.nlm.nih.gov). This NICD is the key effector of Notch signaling: it translocates from the cytoplasm into the nucleus to regulate gene expression (pmc.ncbi.nlm.nih.gov). The NICD contains several functional domains: an RBPJ association module (RAM) near its N-terminus, seven ankyrin repeats (ANK) that serve as protein–protein interaction surfaces, two nuclear localization sequences (NLS) flanking the ANK region (ensuring NICD enters the nucleus), and a C-terminal PEST domain rich in proline, glutamic acid, serine, threonine (pmc.ncbi.nlm.nih.gov). The PEST motif carries degradation signals that target NICD for ubiquitin-mediated proteasomal turnover, thereby limiting the duration of Notch1 signaling (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Notch1’s overall architecture is shared by other Notch receptors, with Notch2–4 having similar domain organization and differing mostly in the number of EGF repeats and length of their PEST regions (pmc.ncbi.nlm.nih.gov).
Once liberated by γ-secretase, the Notch1 intracellular domain (NICD) acts as a transcriptional regulator. Canonical Notch signaling involves NICD partnering with a DNA-binding protein of the CSL family (also known as RBPJ in mammals, CBF1/Su(H)/Lag-1 in other species) (www.nature.com) (pmc.ncbi.nlm.nih.gov). In the absence of NICD, RBPJ/CSL is bound to target gene promoters along with corepressor proteins and histone deacetylases, keeping those target genes silenced (pmc.ncbi.nlm.nih.gov). When NICD enters the nucleus, it directly binds to RBPJ/CSL, via the RAM and ankyrin domains, and converts it into a transcriptional activator complex (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). NICD binding displaces the pre-bound corepressors and allows recruitment of coactivator proteins – most importantly, a Mastermind-like (MAML) protein, which bridges NICD and CSL and helps recruit the transcriptional machinery (pmc.ncbi.nlm.nih.gov). The assembled NICD–CSL–MAML complex drives expression of Notch target genes (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). A classic family of direct Notch targets are the Hairy/Enhancer of Split (HES) genes and their relatives the HEY genes, which encode transcriptional repressors that in turn modulate cell differentiation programs (pmc.ncbi.nlm.nih.gov). Thus, the primary outcome of Notch1 activation is changes in gene expression in the signal-receiving cell, typically leading to context-dependent effects like cell fate specification or inhibition of differentiation. Notch signaling is unusual in that the receptor itself (NICD fragment) becomes a part of the nuclear transcription factor complex, a mechanism often described as “signal transduction by proteolysis.” This directness bypasses second messengers and allows immediate transcriptional response to cell–cell interactions (www.nature.com). Importantly, Notch signaling is highly context-dependent – the same signal can have different outcomes depending on the cell type and the network of other signals and transcription factors present (pubmed.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).
The Notch pathway is conserved across metazoans and generally operates at short range, requiring cells to be in direct contact (pmc.ncbi.nlm.nih.gov). Mammals have five canonical Notch ligands (Delta-like 1, 3, 4 and Jagged-1, 2), which are themselves transmembrane proteins presented on adjacent cells (pmc.ncbi.nlm.nih.gov). Notch1–ligand binding is a unidirectional signaling event: the cell expressing the ligand acts as the “signaling” cell, and the cell expressing Notch1 receives the signal. Notch1 activation typically influences binary cell fate decisions – for example, helping one cell adopt a primary fate while its neighbors adopt an alternative fate, a process famously described as lateral inhibition in neurogenesis (pmc.ncbi.nlm.nih.gov). Notch1 can also mediate inductive signaling, where a steady Notch signal drives neighboring cells into a particular differentiated state. The specificity of action is partly achieved by the fact that Notch1’s influence is limited to the nucleus of the cell that produces NICD (there is no diffusion of NICD to other cells), and by the localized nature of ligand–receptor contact (often within epithelial cell junctions or niche microenvironments). After NICD initiates target gene transcription, its activity is attenuated by phosphorylation and ubiquitylation (primarily via the E3 ubiquitin ligase FBXW7 acting on the PEST domain), causing NICD degradation (pmc.ncbi.nlm.nih.gov). This built-in negative feedback ensures Notch1 signals are transient unless continually stimulated by ligand. Notch1 signaling can also be modulated by glycosylation of its EGF repeats (mediated by enzymes like Fringe), which alters ligand binding affinity and receptor activation (pmc.ncbi.nlm.nih.gov).
Recent insights: While the canonical CSL-dependent pathway is the best-understood mode of Notch1 action, studies show that Notch1 has additional non-canonical roles and regulatory modes. For instance, Notch1 and its ligands can interact within the same cell (“cis-interactions”) to inhibit signaling. In a 2024 study, Thambyrajah et al. demonstrated that in embryonic hematopoietic stem cells, Jagged1 ligands expressed on the same cell surface bind Notch1 in cis and prevent its activation, thereby preserving the stem cell fate (pmc.ncbi.nlm.nih.gov). If Notch1 in these cells is forcibly activated (bypassing cis-inhibition), the stem cells prematurely differentiate, indicating that Notch1 inactivity is required to maintain the stem cell state in that context (pmc.ncbi.nlm.nih.gov). This cis-inhibition mechanism highlights how cells can autonomously modulate Notch1 signaling strength by co-expressing ligands, adding a layer of control beyond external ligand availability. Another frontier in Notch1 biology is its transcription-independent functions. A 2023 study reported a form of “Notch1 cortical signaling” in which the Notch1 protein at the cell membrane (particularly the transmembrane domain and remaining juxtamembrane portions after NICD release) helps organize the cortical actin cytoskeleton and cell–cell junctions (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). White et al. (2023) found that Notch1 at epithelial adherens junctions interacts with an effector protein FAM83H and stabilizes E-cadherin-based cell adhesion, which in turn restrains EGFR signaling and excessive cell proliferation (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Notably, this structural role required the presence of the Notch1 transmembrane segment (TMD) but not the NICD, suggesting it operates independently of gene transcription. Such non-canonical functions appear specialized (observed in mammary epithelial architectures and previously in endothelial cells (pmc.ncbi.nlm.nih.gov)) but reveal that Notch1 receptors can influence cell architecture and signaling at the cortex in addition to their classical nuclear role. These discoveries underscore that Notch1 is a versatile signaling module, with ongoing research uncovering new modes of action.
Developmental roles: Notch1 is a master regulator of cell fate during embryonic development. Through iterative cell–cell signaling events, Notch1 helps pattern tissues and coordinate differentiation. In general, Notch1 activation tends to maintain an undifferentiated state or progenitor character in cells that receive the signal, thereby postponing or redirecting their differentiation. For example, in the nervous system, Notch1 signaling in neural progenitor cells inhibits neuronal differentiation, ensuring that not all cells convert into neurons at once. This mechanism – initially discovered from the neurogenic phenotype of Notch mutants in flies – is conserved in mammals and is critical for balancing neural stem cell maintenance with neuron production (www.nature.com). Loss of Notch activity in neural precursors leads to premature neuronal differentiation and depletion of the progenitor pool, whereas excessive Notch1 can block neurons from forming. Notch1 also plays repeated roles at later stages of neurodevelopment, influencing gliogenesis and synaptic patterning (often through induction of Hes/Hey genes that suppress proneural factors). Because of these roles, Notch1 is required for proper brain development and has been implicated in neurodevelopmental disorders when dysregulated (www.nature.com).
In the hematopoietic and immune system, Notch1 provides a famous example of a binary cell-fate switch. Notch1 signaling is essential for T-cell lineage commitment in the thymus. Experimental studies showed that if Notch1 is disabled in hematopoietic progenitor cells, those progenitors fail to become T cells and instead default to the B-cell lineage – even when they reside in the thymic environment (pmc.ncbi.nlm.nih.gov). In a landmark 2001 study, Radtke and colleagues demonstrated that Notch1–deficient common lymphoid precursors adopt a B cell fate in the thymus, whereas normally the thymus (via Notch-Delta signals) instructs them to become T cells (pmc.ncbi.nlm.nih.gov). Thus, Notch1 serves as a pivotal switch that directs lymphoid precursors towards the T cell program and away from the B cell program. Consistently, Delta-like ligands (especially DLL4) presented by thymic epithelial cells activate Notch1 on immigrant progenitors to trigger the T-cell developmental pathway. Beyond T cells, Notch1 (and related receptors) also influence other blood cell lineages and the formation of hematopoietic stem cells. During embryogenesis, Notch1 is required for the emergence of definitive hematopoietic stem cells from hemogenic endothelium in the aorta-gonad-mesonephros region (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). If Notch signaling is blocked at that stage, fewer HSCs are produced. In the adult bone marrow, Notch signals (from niche cells) continue to support HSC maintenance and may bias differentiation outcomes for lymphocytes and other lineages, although redundancy with other Notch receptors exists.
Notch1 is indispensable for proper organogenesis and tissue patterning. Mice lacking functional Notch1 die in mid-gestation, reflecting widespread developmental failures (www.nature.com). Notch1-null or Notch1 signal–deficient embryos display defects in somite segmentation (leading to irregular formation of the vertebral column segments) and in vascular development (www.nature.com). Notch1, together with DLL1 and DLL4, is crucial for the formation of the embryonic vasculature: it helps specify arterial endothelial cell identity and coordinate angiogenic sprouting. For instance, in developing blood vessels, cells with higher Notch1 activity adopt an arterial fate while suppressing venous differentiation, and Notch1-DLL4 interactions between endothelial tip and stalk cells refine the pattern of new vessel branching. Notch1 is also involved in the development of the heart (cardiac outflow tract and valves), pancreas, kidneys, and many other structures by modulating the differentiation of progenitors in those tissues. In each context, Notch1 often acts reiteratively: for example, controlling the proliferation of a progenitor pool, then later influencing the choice of specific cell subtypes that arise. Many of these roles have been defined by conditional knockout studies in mice. In the intestinal epithelium, Notch1 and Notch2 signals maintain the balance between absorptive enterocytes and secretory cells (goblet and others) – Notch activation promotes the absorptive cell fate and prevents secretory differentiation. Accordingly, inhibiting Notch (with γ-secretase inhibitors) in adult mice causes a rapid increase in goblet cells in the gut and loss of proliferative crypt progenitors, explaining why diarrhea is a side effect of systemic Notch blockade (pmc.ncbi.nlm.nih.gov). Notch1 signaling similarly maintains stem or progenitor states in the skin, inner ear, lung airways, and other renewing tissues, while coordinating proper differentiation timing. As Bray and Bigas (2025) note, Notch signaling often has “iterative roles” during development – first controlling the state of a progenitor, then later the fate of its progeny – and these roles can continue into adulthood in tissue maintenance and repair (www.nature.com). For example, Notch1 activity persists in adult neural stem cell niches (subventricular zone and hippocampus), where it restrains differentiation and promotes stem cell self-renewal, contributing to ongoing neurogenesis in a regulated manner (www.nature.com). In summary, Notch1’s primary biological function is to act as a context-dependent cell fate regulator: by transmitting local cell–cell signals into changes in gene expression, it shapes developmental patterning and ensures the proper balance between progenitors and differentiated cells in many tissues (pmc.ncbi.nlm.nih.gov) (www.nature.com).
Homeostasis and regeneration: Notch1’s influence extends beyond embryonic development into adult tissue homeostasis. Many adult stem cell systems exploit Notch signaling to control differentiation. We have mentioned the intestine and bone marrow as examples; similarly, in the epidermis, Notch1 promotes differentiation of keratinocytes. When Notch1 is active in a basal skin cell, it drives that cell to exit the stem cell compartment and differentiate into a spinous/intermediate cell, helping form the stratified layers. If Notch1 is lost in skin progenitors, those cells can expand excessively and fail to differentiate properly (www.nature.com). This role of Notch1 in inducing differentiation in skin (and thus restraining unchecked growth) is one reason that Notch1 is considered a tumor suppressor in the epidermis – Notch1-deficient skin can develop epidermal cancers (squamous cell carcinomas) due to accumulation of undifferentiated, proliferative cells (www.nature.com). In other contexts, Notch1 can act to support proliferation: for example, Notch signaling is involved in liver regeneration and cardiac injury responses, where it may help reactive progenitor cells expand or transform. The outcome depends on how the Notch1 targets interface with other pathways (e.g. Notch1 crosstalks with Wnt, TGF-β, and hypoxia pathways in various stem cell niches (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov)). Overall, Notch1 provides a means for cells in a community (tissue) to communicate and coordinate behavior, maintaining tissue architecture. This is vividly illustrated by the recent finding that Notch1 at cell junctions strengthens adhesion: in a confluent epithelial layer, Notch1’s presence at the cortex helps cells sense confluency and suppresses further growth (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). In summary, from embryogenesis through adulthood, Notch1 plays a “gate-keeper” role in cell fate and differentiation, ensuring the right cells form at the right time and place, and that stem cell pools are neither prematurely exhausted nor overgrown. When this regulation goes awry, developmental defects or diseases can result.
Given its central role in regulating cell proliferation and differentiation, it is not surprising that NOTCH1 is involved in many diseases. Aberrant Notch1 signaling – either excessive or deficient – can contribute to oncogenesis, developmental syndromes, and other pathologies. Notch1 is somewhat unusual in that it can function as an oncogene in some tissues and a tumor suppressor in others (pmc.ncbi.nlm.nih.gov) (www.nature.com).
Oncogenic Notch1: The clearest example of Notch1 as an oncogenic driver is in T-cell acute lymphoblastic leukemia (T-ALL). NOTCH1 was first linked to human T-ALL in the early 1990s, and subsequent genomic studies revealed that more than 50% of T-ALL patients have somatic activating mutations in the NOTCH1 gene (pmc.ncbi.nlm.nih.gov). These mutations typically occur either in the HD domain (extracellular heterodimerization region) or in the C-terminal PEST domain of Notch1 (pmc.ncbi.nlm.nih.gov). HD domain mutations (e.g. small deletions or amino-acid substitutions) destabilize the autoinhibited conformation, essentially making the receptor prone to ligand-independent activation (pmc.ncbi.nlm.nih.gov). PEST domain mutations remove the degron signals, prolonging the NICD’s half-life in the nucleus (pmc.ncbi.nlm.nih.gov). Both types of mutations lead to excessive Notch1 signaling in T-cell progenitors. This drives leukemia by altering transcription of genes that control cell growth and metabolism – for example, Notch1 directly upregulates MYC and other oncogenic programs in T-ALL cells (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). In mouse models, forced activation of Notch1 in hematopoietic stem cells or thymocytes is sufficient to induce T-cell leukemias (pmc.ncbi.nlm.nih.gov). The clinical relevance is significant: NOTCH1 status is being explored as a prognostic marker in T-ALL, and components of Notch signaling are targets for therapy (see below). Notch1 is also mutated or overactivated in certain solid tumors. For instance, about 10–15% of human non-small cell lung carcinomas (especially lung adenocarcinoma) have mutations in Notch pathway genes, sometimes including NOTCH1. Notch1 activation is linked to poor differentiation and stem-like tumor cell phenotype in some solid cancers such as triple-negative breast cancer and pancreatic ductal carcinoma (pmc.ncbi.nlm.nih.gov). On the other hand, in some tumors Notch1 acts as a tumor suppressor: frequent loss-of-function mutations in NOTCH1 are found in squamous cell carcinomas of the skin, esophagus, and head and neck (www.nature.com), suggesting that when Notch1’s prodifferentiation signal is removed, cells become prone to malignant transformation. Indeed, a study in mouse skin showed that Notch1 deletion led to spontaneous basal cell carcinomas, whereas activating Notch1 caused those cells to exit the cell cycle via differentiation (www.nature.com). This dichotomy exemplifies the context-dependent nature of Notch1 – promoting cancer in settings like T cells (where it sustains an undifferentiated, proliferative state) but suppressing cancer in settings like stratified epithelia (where it is needed to induce differentiation of potential cancer-initiating cells). Beyond cancer, germline mutations in Notch pathway components can cause developmental disorders. NOTCH1 germline mutations in humans have been associated with congenital heart defects, such as bicuspid aortic valve and left ventricular outflow tract malformations (pmc.ncbi.nlm.nih.gov). In these cases, heterozygous loss of Notch1 impairs valve formation and can lead to early-onset calcification of valves (pmc.ncbi.nlm.nih.gov). (Mutations in the ligand JAG1 or in NOTCH2 cause Alagille syndrome, a complex developmental disease affecting the liver, heart, and other organs (pmc.ncbi.nlm.nih.gov) – highlighting again that balanced Notch signaling is vital for normal organ development.)
Therapeutic targeting of Notch1: The prominent role of Notch1 in diseases like T-ALL has motivated efforts to develop Notch pathway inhibitors. The simplest way to block Notch signaling is to prevent NICD production via γ-secretase inhibitors (GSIs), since γ-secretase is required for S3 cleavage of all Notch receptors. In fact, one of the first clinical trials (launched in 2006) for Notch-related therapy used a GSI (MK-0752) in patients with refractory T-ALL (pmc.ncbi.nlm.nih.gov). The drug did achieve a reduction in leukemia burden in some cases (one T-ALL patient had ~45% tumor mass reduction in 4 weeks), but unfortunately the trial had to be halted due to dose-limiting toxicity – namely, severe gastrointestinal side effects (secretory diarrhea) (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This toxicity was anticipated from animal studies: GSIs cause an overproduction of goblet cells in the intestines by blocking Notch1/2, disrupting gut homeostasis. The GSI trial outcome underscored a key challenge: Notch1 is so important in normal physiology that systemic inhibition leads to mechanism-related side effects (pmc.ncbi.nlm.nih.gov). Since then, researchers have pursued more selective strategies to inhibit Notch1 in cancer while sparing other tissues. One approach has been to develop monoclonal antibodies against specific Notch receptors or ligands. Brontictuzumab is a humanized antibody that binds the negative regulatory region of NOTCH1, stabilizing the autoinhibited conformation and preventing ligand activation. In a Phase I study (initiated 2013) of brontictuzumab in patients with advanced solid tumors, there were signs of anti-tumor activity: 2 out of 48 patients achieved partial tumor responses and 4 others had stable disease for ≥6 months, particularly in tumors like adenoid cystic carcinoma that are known to often have aberrant Notch activation (pmc.ncbi.nlm.nih.gov). Notably, adenoid cystic carcinomas with activating NOTCH1 mutations responded, suggesting target engagement (pmc.ncbi.nlm.nih.gov). However, even with this receptor-specific blockade, toxicities were observed – including grade 3 diarrhea and fatigue in some patients, which were dose-limiting (pmc.ncbi.nlm.nih.gov). These events reflect on-target effects of Notch1 inhibition in normal gut and perhaps other tissues. Other Notch-targeting agents have been tested, such as antibodies against Notch2/3 (e.g. tarextumab) and ligand blockers or decoys, with mixed results and sometimes unexpected pro-tumor effects in certain contexts (since Notch can also suppress tumors). There are also inhibitors of the Notch transcription complex under investigation (e.g. small molecules inhibiting RBPJ–NICD interaction or MAML function) (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov), which might offer another route to dial down Notch1-driven gene expression. None of these therapies have yet achieved regulatory approval, due in part to the narrow therapeutic window.
Interestingly, one area where Notch1 status is being leveraged is cancer immunotherapy. Emerging evidence suggests that tumors harboring Notch pathway mutations (often loss-of-function) may respond differently to immune checkpoint blockade. Notch-inactivating mutations can lead to a less differentiated, more antigenic tumor cell phenotype and a pro-inflammatory microenvironment – for example, via increased T cell infiltration or higher expression of immune genes (pmc.ncbi.nlm.nih.gov). A recent clinical study in 2023 found that NSCLC patients with NOTCH1 mutations had significantly better outcomes on PD-1/PD-L1 inhibitor therapy than those with wild-type Notch1 (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Specifically, NOTCH1-mutant lung cancer patients showed higher tumor mutational burden and achieved superior overall survival under checkpoint blockade (median overall survival was longer, and on multivariate analysis Notch1 mutation was associated with a hazard ratio ~0.4 for death) (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This suggests that loss of Notch1 signaling in a tumor might increase immune visibility (perhaps by upregulating neoantigen expression or interferon pathways), making them more susceptible to immunotherapy. While this finding needs further validation, it points to NOTCH1 mutation as a potential biomarker for immunotherapy response in certain cancers. More broadly, it exemplifies how deepening our understanding of Notch1’s role in tumor biology could inform personalized treatment strategies – either by directly targeting the pathway or by exploiting its downstream effects on tumor–immune interactions.
Conclusion: Notch1 is a fundamental signaling protein that ties together cell-to-cell communication with gene regulation. Through its ligand-induced proteolysis mechanism, Notch1 directly converts external signals at the cell membrane into changes in transcriptional programs in the nucleus. It controls critical decisions in cell fate, proliferation, and differentiation in a context-dependent manner. Modern research (2023–2024) continues to reveal new facets of Notch1 biology – from cis-inhibitory loops that fine-tune stem cell signals (pmc.ncbi.nlm.nih.gov), to non-traditional roles in strengthening cell junctions and controlling cell polarity (pmc.ncbi.nlm.nih.gov). These insights expand our view of how Notch1 functions beyond the classical paradigm. Clinically, Notch1 stands as a double-edged sword: its dysregulation can lead to severe diseases, yet it is a challenging therapeutic target due to its importance in normal physiology. Ongoing work in developmental biology, structural biochemistry, and clinical oncology is converging to unravel how to modulate Notch1 safely and effectively. By learning how Notch1’s “molecular decisions” are made and modulated, scientists hope to design interventions that can, for example, shut down a Notch1-driven leukemia or stimulate regenerative healing in tissues, without collateral damage. Notch1 thus remains a focus of intense research as both a paradigm of cell signaling and a key node in human health and disease (pmc.ncbi.nlm.nih.gov) (www.nature.com).
References: (Publication dates and URLs are provided in citations throughout the text)
Source: Notch1-deep-research-bioreason-rl.md
The BioReason functional summary is largely accurate:
A single-pass cell-surface receptor that uses a long calcium-stabilized EGF repeat array to sense extracellular cues and trigger intramembrane signaling. Upon ligand engagement and endocytic activation, a built-in regulatory switch releases the intracellular tail, which then assembles transcriptional effector complexes via ankyrin repeats to reprogram gene expression. This signaling cascade governs binary fate decisions and timing of differentiation by coupling extracellular recognition to intracellular transcriptional control at the plasma membrane.
This correctly describes: (1) the EGF repeat extracellular domain with calcium stabilization, (2) the proteolytic activation mechanism (intramembrane signaling), (3) the release of the intracellular domain (NICD), (4) the ankyrin repeat-mediated assembly of transcriptional complexes, and (5) the role in cell fate determination (GO:0001708). The curated review confirms Notch1 as "the canonical mouse Notch receptor" with roles in "cell-fate decisions during embryogenesis and tissue homeostasis."
The mention of "endocytic activation" is slightly misleading -- endocytosis by the ligand-presenting (signal-sending) cell provides the pulling force, but the Notch-bearing cell undergoes proteolytic cleavage at the membrane. The summary could be read as suggesting the Notch receptor itself is endocytosed for activation, which is not the primary mechanism.
A minor inaccuracy: the primary molecular function is described as "protein binding" (GO:0005515), which is too generic. The curated review identifies more specific functions including GO:0005112 (Notch binding), GO:0038023 (signaling receptor activity), and the transcriptional coactivator role. BioReason does not explicitly name the RBPJ/CSL transcription factor partnership in the summary, though the thinking trace does.
Comparison with interpro2go:
The curated review has six GO_REF:0000002 annotations: GO:0005509 (calcium ion binding), GO:0006355 (regulation of DNA-templated transcription), GO:0030154 (cell differentiation), GO:0038023 (signaling receptor activity), GO:0042981 (regulation of apoptotic process), and GO:0050793 (regulation of developmental process). BioReason's functional summary captures most of these conceptually (calcium stabilization, transcriptional regulation, cell fate/differentiation, receptor signaling) but misses the apoptotic connection. BioReason adds substantial value in explaining the proteolytic activation mechanism and the NOD/NODP regulatory switch, which interpro2go cannot convey.
The trace provides excellent analysis of the domain architecture, correctly interpreting the EGF repeat array, the NOD/NODP negative regulatory region, and the ankyrin repeat transcriptional scaffold. The mechanistic model of force-dependent activation and intramembrane proteolysis is accurate. The mention of Delta/Serrate/Jagged ligands and CSL/RBPJ complexes shows good biological context.
id: Q01705
gene_symbol: Notch1
product_type: PROTEIN
status: IN_PROGRESS
taxon:
id: NCBITaxon:10090
label: Mus musculus
description: Notch1 is the canonical mouse Notch receptor, a single-pass transmembrane protein that mediates juxtacrine cell-cell
signaling. Ligand binding by DLL/JAG family proteins triggers ADAM and gamma-secretase cleavage, releasing the Notch intracellular
domain (NICD), which enters the nucleus and forms an RBPJ/MAML transcriptional coactivator complex to activate target genes.
In mouse, Notch1 has central roles in cell-fate decisions during embryogenesis and tissue homeostasis, with especially strong
evidence for cardiovascular development, neurogenesis/gliogenesis, hematopoietic stem cell regulation, angiogenesis, and
inhibition of myogenic differentiation.
alternative_products:
- name: '1'
id: Q01705-1
- name: '2'
id: Q01705-2
sequence_note: VSP_001402, VSP_001403, VSP_001404
- name: '3'
id: Q01705-3
sequence_note: VSP_043064
- name: '4'
id: Q01705-4
sequence_note: VSP_043065
existing_annotations:
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007411
label: axon guidance
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0009986
label: cell surface
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043235
label: receptor complex
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001525
label: angiogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001701
label: in utero embryonic development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001947
label: heart looping
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002011
label: morphogenesis of an epithelial sheet
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002064
label: epithelial cell development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002437
label: inflammatory response to antigenic stimulus
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005509
label: calcium ion binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006355
label: regulation of DNA-templated transcription
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006959
label: humoral immune response
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010001
label: glial cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010718
label: positive regulation of epithelial to mesenchymal transition
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010720
label: positive regulation of cell development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0012505
label: endomembrane system
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016020
label: membrane
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030154
label: cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030326
label: embryonic limb morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030513
label: positive regulation of BMP signaling pathway
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030858
label: positive regulation of epithelial cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031902
label: late endosome membrane
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035850
label: epithelial cell differentiation involved in kidney development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0038023
label: signaling receptor activity
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042981
label: regulation of apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045165
label: cell fate commitment
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048589
label: developmental growth
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048608
label: reproductive structure development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048844
label: artery morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0050793
label: regulation of developmental process
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070986
label: left/right axis specification
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072012
label: glomerulus vasculature development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072080
label: nephron tubule development
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000136
label: regulation of cell proliferation involved in heart morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:17210915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21102556
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22258620
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:38891776
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:8749394
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001554
label: luteolysis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001669
label: acrosomal vesicle
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001837
label: epithelial to mesenchymal transition
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002052
label: positive regulation of neuroblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002193
label: MAML1-RBP-Jkappa- ICN1 complex
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003151
label: outflow tract morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003184
label: pulmonary valve morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003192
label: mitral valve formation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003264
label: regulation of cardioblast proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003713
label: transcription coactivator activity
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004888
label: transmembrane signaling receptor activity
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007221
label: positive regulation of transcription of Notch receptor target
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007283
label: spermatogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007507
label: heart development
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008284
label: positive regulation of cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010629
label: negative regulation of gene expression
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010667
label: negative regulation of cardiac muscle cell apoptotic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010812
label: negative regulation of cell-substrate adhesion
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0021515
label: cell differentiation in spinal cord
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031100
label: animal organ regeneration
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0032496
label: response to lipopolysaccharide
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0032966
label: negative regulation of collagen biosynthetic process
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035148
label: tube formation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035924
label: cellular response to vascular endothelial growth factor stimulus
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042127
label: regulation of cell population proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042246
label: tissue regeneration
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042802
label: identical protein binding
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043235
label: receptor complex
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045603
label: positive regulation of endothelial cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045662
label: negative regulation of myoblast differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045665
label: negative regulation of neuron differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045687
label: positive regulation of glial cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0046579
label: positive regulation of Ras protein signal transduction
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048708
label: astrocyte differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048709
label: oligodendrocyte differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0051152
label: positive regulation of smooth muscle cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060354
label: negative regulation of cell adhesion molecule production
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060412
label: ventricular septum morphogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0062043
label: positive regulation of cardiac epithelial to mesenchymal transition
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070374
label: positive regulation of ERK1 and ERK2 cascade
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071228
label: cellular response to tumor cell
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071372
label: cellular response to follicle-stimulating hormone stimulus
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090051
label: negative regulation of cell migration involved in sprouting angiogenesis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0097150
label: neuronal stem cell population maintenance
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000048
label: negative regulation of cell-cell adhesion mediated by cadherin
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000737
label: negative regulation of stem cell differentiation
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000811
label: negative regulation of anoikis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2001027
label: negative regulation of endothelial cell chemotaxis
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001837
label: epithelial to mesenchymal transition
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002193
label: MAML1-RBP-Jkappa- ICN1 complex
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003151
label: outflow tract morphogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003184
label: pulmonary valve morphogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003192
label: mitral valve formation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003713
label: transcription coactivator activity
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004888
label: transmembrane signaling receptor activity
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007507
label: heart development
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008284
label: positive regulation of cell population proliferation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010629
label: negative regulation of gene expression
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010812
label: negative regulation of cell-substrate adhesion
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035148
label: tube formation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035924
label: cellular response to vascular endothelial growth factor stimulus
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042802
label: identical protein binding
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045662
label: negative regulation of myoblast differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0046579
label: positive regulation of Ras protein signal transduction
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0051152
label: positive regulation of smooth muscle cell differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060354
label: negative regulation of cell adhesion molecule production
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060412
label: ventricular septum morphogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070374
label: positive regulation of ERK1 and ERK2 cascade
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071228
label: cellular response to tumor cell
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071372
label: cellular response to follicle-stimulating hormone stimulus
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090051
label: negative regulation of cell migration involved in sprouting angiogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000048
label: negative regulation of cell-cell adhesion mediated by cadherin
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000737
label: negative regulation of stem cell differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000811
label: negative regulation of anoikis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2001027
label: negative regulation of endothelial cell chemotaxis
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IDA
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000137
label: negative regulation of cell proliferation involved in heart morphogenesis
evidence_type: IDA
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000137
label: negative regulation of cell proliferation involved in heart morphogenesis
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1990433
label: CSL-Notch-Mastermind transcription factor complex
evidence_type: ISO
original_reference_id: GO_REF:0000119
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001669
label: acrosomal vesicle
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002052
label: positive regulation of neuroblast proliferation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003264
label: regulation of cardioblast proliferation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004888
label: transmembrane signaling receptor activity
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007221
label: positive regulation of transcription of Notch receptor target
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007283
label: spermatogenesis
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010667
label: negative regulation of cardiac muscle cell apoptotic process
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0032966
label: negative regulation of collagen biosynthetic process
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042127
label: regulation of cell population proliferation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045603
label: positive regulation of endothelial cell differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045665
label: negative regulation of neuron differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045687
label: positive regulation of glial cell differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048708
label: astrocyte differentiation
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0062043
label: positive regulation of cardiac epithelial to mesenchymal transition
evidence_type: ISO
original_reference_id: GO_REF:0000096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098685
label: Schaffer collateral - CA1 synapse
evidence_type: IMP
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098685
label: Schaffer collateral - CA1 synapse
evidence_type: IDA
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098685
label: Schaffer collateral - CA1 synapse
evidence_type: IMP
original_reference_id: PMID:26635527
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098685
label: Schaffer collateral - CA1 synapse
evidence_type: IDA
original_reference_id: PMID:26635527
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098839
label: postsynaptic density membrane
evidence_type: IEP
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098839
label: postsynaptic density membrane
evidence_type: IDA
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098839
label: postsynaptic density membrane
evidence_type: IDA
original_reference_id: PMID:26635527
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098978
label: glutamatergic synapse
evidence_type: IMP
original_reference_id: PMID:26635527
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0098978
label: glutamatergic synapse
evidence_type: IDA
original_reference_id: PMID:26635527
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0099565
label: chemical synaptic transmission, postsynaptic
evidence_type: IMP
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0099565
label: chemical synaptic transmission, postsynaptic
evidence_type: IDA
original_reference_id: PMID:21315255
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IGI
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0061344
label: regulation of cell adhesion involved in heart morphogenesis
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070168
label: negative regulation of biomineral tissue development
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:22110751
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010008
label: endosome membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9793875
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010832
label: negative regulation of myotube differentiation
evidence_type: IMP
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0050768
label: negative regulation of neurogenesis
evidence_type: IMP
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071456
label: cellular response to hypoxia
evidence_type: IDA
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0140537
label: transcription regulator activator activity
evidence_type: IDA
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006357
label: regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060379
label: cardiac muscle cell myoblast differentiation
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:27719760
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18430783
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030163
label: protein catabolic process
evidence_type: IDA
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006606
label: protein import into nucleus
evidence_type: IDA
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010467
label: gene expression
evidence_type: IDA
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072538
label: T-helper 17 type immune response
evidence_type: IDA
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0097400
label: interleukin-17-mediated signaling pathway
evidence_type: IDA
original_reference_id: PMID:28561022
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007221
label: positive regulation of transcription of Notch receptor target
evidence_type: IGI
original_reference_id: PMID:12794108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007221
label: positive regulation of transcription of Notch receptor target
evidence_type: IGI
original_reference_id: PMID:23160044
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003713
label: transcription coactivator activity
evidence_type: IDA
original_reference_id: PMID:17658278
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003713
label: transcription coactivator activity
evidence_type: IDA
original_reference_id: PMID:9111338
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003713
label: transcription coactivator activity
evidence_type: IDA
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070168
label: negative regulation of biomineral tissue development
evidence_type: IDA
original_reference_id: PMID:23583836
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0120163
label: negative regulation of cold-induced thermogenesis
evidence_type: IMP
original_reference_id: PMID:25038826
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003182
label: coronary sinus valve morphogenesis
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003184
label: pulmonary valve morphogenesis
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003332
label: negative regulation of extracellular matrix constituent secretion
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010614
label: negative regulation of cardiac muscle hypertrophy
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060412
label: ventricular septum morphogenesis
evidence_type: IMP
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1902339
label: positive regulation of apoptotic process involved in morphogenesis
evidence_type: IDA
original_reference_id: PMID:26491108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: IGI
original_reference_id: PMID:27107132
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003184
label: pulmonary valve morphogenesis
evidence_type: IGI
original_reference_id: PMID:27107132
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003203
label: endocardial cushion morphogenesis
evidence_type: IGI
original_reference_id: PMID:27107132
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048873
label: homeostasis of number of cells within a tissue
evidence_type: IGI
original_reference_id: PMID:27107132
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060412
label: ventricular septum morphogenesis
evidence_type: IGI
original_reference_id: PMID:27107132
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: IGI
original_reference_id: PMID:23583836
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:23583836
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IGI
original_reference_id: PMID:23583836
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28089369
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28498977
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048845
label: venous blood vessel morphogenesis
evidence_type: IMP
original_reference_id: PMID:18952909
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1903849
label: positive regulation of aorta morphogenesis
evidence_type: IMP
original_reference_id: PMID:18952909
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010468
label: regulation of gene expression
evidence_type: IMP
original_reference_id: PMID:11076679
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21191019
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045070
label: positive regulation of viral genome replication
evidence_type: IMP
original_reference_id: PMID:21191019
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003197
label: endocardial cushion development
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:21985982
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:18676613
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:24715457
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005912
label: adherens junction
evidence_type: IDA
original_reference_id: PMID:24715457
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016324
label: apical plasma membrane
evidence_type: IDA
original_reference_id: PMID:24715457
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:12050162
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006357
label: regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: IMP
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0042127
label: regulation of cell population proliferation
evidence_type: IGI
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045607
label: regulation of inner ear auditory receptor cell differentiation
evidence_type: IMP
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045608
label: negative regulation of inner ear auditory receptor cell differentiation
evidence_type: IMP
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090090
label: negative regulation of canonical Wnt signaling pathway
evidence_type: IMP
original_reference_id: PMID:25535395
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005112
label: Notch binding
evidence_type: IPI
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005783
label: endoplasmic reticulum
evidence_type: IDA
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008593
label: regulation of Notch signaling pathway
evidence_type: IGI
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031410
label: cytoplasmic vesicle
evidence_type: IDA
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045747
label: positive regulation of Notch signaling pathway
evidence_type: IDA
original_reference_id: PMID:24667410
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0071944
label: cell periphery
evidence_type: IDA
original_reference_id: PMID:23284756
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043235
label: receptor complex
evidence_type: ISO
original_reference_id: PMID:23382219
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060271
label: cilium assembly
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1902263
label: apoptotic process involved in embryonic digit morphogenesis
evidence_type: IMP
original_reference_id: PMID:16245338
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001726
label: ruffle
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005856
label: cytoskeleton
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030027
label: lamellipodium
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008285
label: negative regulation of cell population proliferation
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035148
label: tube formation
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035924
label: cellular response to vascular endothelial growth factor stimulus
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090051
label: negative regulation of cell migration involved in sprouting angiogenesis
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2001027
label: negative regulation of endothelial cell chemotaxis
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035914
label: skeletal muscle cell differentiation
evidence_type: IMP
original_reference_id: PMID:22147266
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:17685488
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:16025100
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:16025100
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:17303760
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003180
label: aortic valve morphogenesis
evidence_type: ISS
original_reference_id: GO_REF:0000024
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003213
label: cardiac right atrium morphogenesis
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003241
label: growth involved in heart morphogenesis
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0014031
label: mesenchymal cell development
evidence_type: IMP
original_reference_id: PMID:17303760
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030279
label: negative regulation of ossification
evidence_type: IMP
original_reference_id: PMID:21493891
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IMP
original_reference_id: PMID:19695258
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:15107403
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0055008
label: cardiac muscle tissue morphogenesis
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060045
label: positive regulation of cardiac muscle cell proliferation
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060317
label: cardiac epithelial to mesenchymal transition
evidence_type: IMP
original_reference_id: PMID:17303760
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060411
label: cardiac septum morphogenesis
evidence_type: IMP
original_reference_id: PMID:20007915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060842
label: arterial endothelial cell differentiation
evidence_type: IMP
original_reference_id: PMID:15107403
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001947
label: heart looping
evidence_type: IGI
original_reference_id: PMID:12730124
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003160
label: endocardium morphogenesis
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003162
label: atrioventricular node development
evidence_type: IMP
original_reference_id: PMID:21266778
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003169
label: coronary vein morphogenesis
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003181
label: atrioventricular valve morphogenesis
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003181
label: atrioventricular valve morphogenesis
evidence_type: IMP
original_reference_id: PMID:21266778
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003198
label: epithelial to mesenchymal transition involved in endocardial cushion formation
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003203
label: endocardial cushion morphogenesis
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003207
label: cardiac chamber formation
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003208
label: cardiac ventricle morphogenesis
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003209
label: cardiac atrium morphogenesis
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003214
label: cardiac left ventricle morphogenesis
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003273
label: cell migration involved in endocardial cushion formation
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003344
label: pericardium morphogenesis
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003344
label: pericardium morphogenesis
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003344
label: pericardium morphogenesis
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010718
label: positive regulation of epithelial to mesenchymal transition
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030334
label: regulation of cell migration
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030335
label: positive regulation of cell migration
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060038
label: cardiac muscle cell proliferation
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060843
label: venous endothelial cell differentiation
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060948
label: cardiac vascular smooth muscle cell development
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060956
label: endocardial cell differentiation
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060979
label: vasculogenesis involved in coronary vascular morphogenesis
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060982
label: coronary artery morphogenesis
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0061384
label: heart trabecula morphogenesis
evidence_type: IMP
original_reference_id: PMID:20890042
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070986
label: left/right axis specification
evidence_type: IGI
original_reference_id: PMID:12730124
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1901201
label: regulation of extracellular matrix assembly
evidence_type: IMP
original_reference_id: PMID:21311046
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1901189
label: positive regulation of ephrin receptor signaling pathway
evidence_type: IC
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003157
label: endocardium development
evidence_type: IMP
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003222
label: ventricular trabecula myocardium morphogenesis
evidence_type: IMP
original_reference_id: PMID:17336907
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-4396387
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9667655
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9824206
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9824230
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9824231
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9824278
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2064853
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2064883
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2065560
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005654
label: nucleoplasm
evidence_type: TAS
original_reference_id: Reactome:R-NUL-4396363
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2067638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-MMU-209285
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2065902
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:17573339
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0019899
label: enzyme binding
evidence_type: IPI
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:19245366
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004857
label: enzyme inhibitor activity
evidence_type: IDA
original_reference_id: PMID:17573339
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:18299578
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IDA
original_reference_id: PMID:21419176
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043086
label: negative regulation of catalytic activity
evidence_type: IDA
original_reference_id: PMID:17573339
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2053938
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2053963
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2066712
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2067638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2071906
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2077477
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2077479
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2065902
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005576
label: extracellular region
evidence_type: TAS
original_reference_id: Reactome:R-NUL-209162
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000139
label: Golgi membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2023158
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000139
label: Golgi membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2032750
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005789
label: endoplasmic reticulum membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2023179
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005789
label: endoplasmic reticulum membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2032750
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005789
label: endoplasmic reticulum membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-9824249
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005789
label: endoplasmic reticulum membrane
evidence_type: TAS
original_reference_id: Reactome:R-NUL-1986584
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-209285
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2063915
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-NUL-209162
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2053938
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:15574878
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0009986
label: cell surface
evidence_type: IDA
original_reference_id: PMID:15574878
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002437
label: inflammatory response to antigenic stimulus
evidence_type: IGI
original_reference_id: PMID:17658279
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006959
label: humoral immune response
evidence_type: IGI
original_reference_id: PMID:17658279
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003219
label: cardiac right ventricle formation
evidence_type: IMP
original_reference_id: PMID:19620969
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IMP
original_reference_id: PMID:19620969
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090090
label: negative regulation of canonical Wnt signaling pathway
evidence_type: IMP
original_reference_id: PMID:19620969
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:20547764
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030513
label: positive regulation of BMP signaling pathway
evidence_type: IDA
original_reference_id: PMID:20547764
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:20547764
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:2000974
label: negative regulation of pro-B cell differentiation
evidence_type: IMP
original_reference_id: PMID:12032823
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0046427
label: positive regulation of receptor signaling pathway via JAK-STAT
evidence_type: IDA
original_reference_id: PMID:15156153
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000122
label: negative regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:12032823
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:12666205
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048711
label: positive regulation of astrocyte differentiation
evidence_type: IDA
original_reference_id: PMID:12666205
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048715
label: negative regulation of oligodendrocyte differentiation
evidence_type: IDA
original_reference_id: PMID:12666205
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060253
label: negative regulation of glial cell proliferation
evidence_type: IDA
original_reference_id: PMID:12666205
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072017
label: distal tubule development
evidence_type: IEP
original_reference_id: PMID:15821257
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072044
label: collecting duct development
evidence_type: IEP
original_reference_id: PMID:15821257
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072144
label: glomerular mesangial cell development
evidence_type: IEP
original_reference_id: PMID:15821257
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IMP
original_reference_id: PMID:19154718
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0009912
label: auditory receptor cell fate commitment
evidence_type: IMP
original_reference_id: PMID:19154718
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045665
label: negative regulation of neuron differentiation
evidence_type: IGI
original_reference_id: PMID:10205173
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045955
label: negative regulation of calcium ion-dependent exocytosis
evidence_type: IMP
original_reference_id: PMID:19251639
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0050679
label: positive regulation of epithelial cell proliferation
evidence_type: IGI
original_reference_id: PMID:19251639
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0032495
label: response to muramyl dipeptide
evidence_type: IDA
original_reference_id: PMID:21156799
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030514
label: negative regulation of BMP signaling pathway
evidence_type: IMP
original_reference_id: PMID:19695258
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045668
label: negative regulation of osteoblast differentiation
evidence_type: IMP
original_reference_id: PMID:19695258
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002051
label: osteoblast fate commitment
evidence_type: NAS
original_reference_id: PMID:16025100
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003160
label: endocardium morphogenesis
evidence_type: IEP
original_reference_id: PMID:16025100
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045892
label: negative regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:16025100
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060528
label: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
evidence_type: IMP
original_reference_id: PMID:16360140
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060740
label: prostate gland epithelium morphogenesis
evidence_type: IMP
original_reference_id: PMID:16360140
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0060768
label: regulation of epithelial cell proliferation involved in prostate gland development
evidence_type: IMP
original_reference_id: PMID:16360140
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001701
label: in utero embryonic development
evidence_type: IMP
original_reference_id: PMID:7789282
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007368
label: determination of left/right symmetry
evidence_type: IMP
original_reference_id: PMID:7789282
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0014807
label: regulation of somitogenesis
evidence_type: IMP
original_reference_id: PMID:7789282
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0021915
label: neural tube development
evidence_type: IMP
original_reference_id: PMID:7789282
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043069
label: negative regulation of programmed cell death
evidence_type: IMP
original_reference_id: PMID:7789282
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:16324690
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045893
label: positive regulation of DNA-templated transcription
evidence_type: IDA
original_reference_id: PMID:9111338
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10958687
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:9315665
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001889
label: liver development
evidence_type: IMP
original_reference_id: PMID:15226394
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010468
label: regulation of gene expression
evidence_type: IMP
original_reference_id: PMID:9102301
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030182
label: neuron differentiation
evidence_type: IMP
original_reference_id: PMID:9102301
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0050767
label: regulation of neurogenesis
evidence_type: IMP
original_reference_id: PMID:9102301
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2053963
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2066712
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2067638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2071906
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2077477
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-MMU-2077479
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: TAS
original_reference_id: Reactome:R-NUL-2065902
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:17079689
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IDA
original_reference_id: PMID:17079689
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045618
label: positive regulation of keratinocyte differentiation
evidence_type: IGI
original_reference_id: PMID:16618808
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045618
label: positive regulation of keratinocyte differentiation
evidence_type: IDA
original_reference_id: PMID:17079689
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:16618808
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IGI
original_reference_id: PMID:16618808
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031490
label: chromatin DNA binding
evidence_type: IDA
original_reference_id: PMID:17658278
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:17658278
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0046533
label: negative regulation of photoreceptor cell differentiation
evidence_type: IMP
original_reference_id: PMID:16452096
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:15965470
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010001
label: glial cell differentiation
evidence_type: IMP
original_reference_id: PMID:15965470
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:16607638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007440
label: foregut morphogenesis
evidence_type: IMP
original_reference_id: PMID:16107537
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045165
label: cell fate commitment
evidence_type: IMP
original_reference_id: PMID:16107537
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0050678
label: regulation of epithelial cell proliferation
evidence_type: IMP
original_reference_id: PMID:16107537
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0002040
label: sprouting angiogenesis
evidence_type: IMP
original_reference_id: PMID:15809373
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031069
label: hair follicle morphogenesis
evidence_type: IMP
original_reference_id: PMID:15978571
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030326
label: embryonic limb morphogenesis
evidence_type: IGI
original_reference_id: PMID:16169548
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IGI
original_reference_id: PMID:16169548
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035116
label: embryonic hindlimb morphogenesis
evidence_type: IMP
original_reference_id: PMID:16245338
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:16145673
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048754
label: branching morphogenesis of an epithelial tube
evidence_type: IMP
original_reference_id: PMID:15064243
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005634
label: nucleus
evidence_type: IDA
original_reference_id: PMID:10206645
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007409
label: axonogenesis
evidence_type: IMP
original_reference_id: PMID:16120638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030900
label: forebrain development
evidence_type: IMP
original_reference_id: PMID:16120638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030900
label: forebrain development
evidence_type: IGI
original_reference_id: PMID:16120638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045665
label: negative regulation of neuron differentiation
evidence_type: IMP
original_reference_id: PMID:16120638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048663
label: neuron fate commitment
evidence_type: IGI
original_reference_id: PMID:16120638
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:15902259
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001708
label: cell fate specification
evidence_type: IMP
original_reference_id: PMID:15068794
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007409
label: axonogenesis
evidence_type: IDA
original_reference_id: PMID:15598981
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030154
label: cell differentiation
evidence_type: IMP
original_reference_id: PMID:12186854
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030216
label: keratinocyte differentiation
evidence_type: IMP
original_reference_id: PMID:15068794
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003682
label: chromatin binding
evidence_type: IDA
original_reference_id: PMID:15689374
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006357
label: regulation of transcription by RNA polymerase II
evidence_type: IGI
original_reference_id: PMID:15689374
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030324
label: lung development
evidence_type: IMP
original_reference_id: PMID:15064243
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045596
label: negative regulation of cell differentiation
evidence_type: IMP
original_reference_id: PMID:15064243
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008284
label: positive regulation of cell population proliferation
evidence_type: IGI
original_reference_id: PMID:15509736
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0045944
label: positive regulation of transcription by RNA polymerase II
evidence_type: IDA
original_reference_id: PMID:12783854
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048103
label: somatic stem cell division
evidence_type: IGI
original_reference_id: PMID:15509736
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0008544
label: epidermis development
evidence_type: IGI
original_reference_id: PMID:15525534
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031069
label: hair follicle morphogenesis
evidence_type: IMP
original_reference_id: PMID:15525534
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0043065
label: positive regulation of apoptotic process
evidence_type: IDA
original_reference_id: PMID:15081359
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0001837
label: epithelial to mesenchymal transition
evidence_type: IMP
original_reference_id: PMID:14701881
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007492
label: endoderm development
evidence_type: IMP
original_reference_id: PMID:14657333
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0030154
label: cell differentiation
evidence_type: IMP
original_reference_id: PMID:14657333
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005886
label: plasma membrane
evidence_type: IC
original_reference_id: PMID:10551863
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007219
label: Notch signaling pathway
evidence_type: IC
original_reference_id: PMID:10551863
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0048103
label: somatic stem cell division
evidence_type: IDA
original_reference_id: PMID:12717450
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007368
label: determination of left/right symmetry
evidence_type: IMP
original_reference_id: PMID:12730124
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:10551863
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0007386
label: compartment pattern specification
evidence_type: IMP
original_reference_id: PMID:12001066
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
references:
- id: GO_REF:0000002
title: Gene Ontology annotation through association of InterPro records with GO terms
findings: []
- id: GO_REF:0000024
title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence
similarity
findings: []
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative
changes to GO terms applied by UniProt
findings: []
- id: GO_REF:0000096
title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
findings: []
- id: GO_REF:0000107
title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
findings: []
- id: GO_REF:0000117
title: Electronic Gene Ontology annotations created by ARBA machine learning models
findings: []
- id: GO_REF:0000119
title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
findings: []
- id: GO_REF:0000120
title: Combined Automated Annotation using Multiple IEA Methods
findings: []
- id: PMID:10205173
title: Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
findings: []
- id: PMID:10206645
title: A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
findings: []
- id: PMID:10551863
title: Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.
findings: []
- id: PMID:10958687
title: Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation
of Notch2.
findings: []
- id: PMID:11076679
title: Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial
signaling through multiple interacting bHLH factors.
findings: []
- id: PMID:12001066
title: Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe
double mutant mice.
findings: []
- id: PMID:12032823
title: Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations.
findings: []
- id: PMID:12050162
title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits
myoblast differentiation via Notch signaling pathway.
findings: []
- id: PMID:12186854
title: Notch1 control of oligodendrocyte differentiation in the spinal cord.
findings: []
- id: PMID:12666205
title: Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.
findings: []
- id: PMID:12717450
title: A role for Wnt signalling in self-renewal of haematopoietic stem cells.
findings: []
- id: PMID:12730124
title: Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.
findings: []
- id: PMID:12783854
title: Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.
findings: []
- id: PMID:12794108
title: 'Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in
T cell development.'
findings: []
- id: PMID:14657333
title: Notch signaling controls multiple steps of pancreatic differentiation.
findings: []
- id: PMID:14701881
title: Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
findings: []
- id: PMID:15064243
title: Functional diversity of notch family genes in fetal lung development.
findings: []
- id: PMID:15068794
title: High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism.
findings: []
- id: PMID:15081359
title: Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.
findings: []
- id: PMID:15107403
title: The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.
findings: []
- id: PMID:15156153
title: Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
findings: []
- id: PMID:15226394
title: Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors.
findings: []
- id: PMID:15509736
title: Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in
telencephalic progenitors.
findings: []
- id: PMID:15525534
title: gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning
or initial morphogenesis.
findings: []
- id: PMID:15574878
title: Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.
findings: []
- id: PMID:15598981
title: Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
findings: []
- id: PMID:15689374
title: RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic
cells.
findings: []
- id: PMID:15809373
title: Essential role of endothelial Notch1 in angiogenesis.
findings: []
- id: PMID:15821257
title: Segmental expression of Notch and Hairy genes in nephrogenesis.
findings: []
- id: PMID:15902259
title: The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
findings: []
- id: PMID:15965470
title: DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
findings: []
- id: PMID:15978571
title: Notch1 is essential for postnatal hair follicle development and homeostasis.
findings: []
- id: PMID:16025100
title: Mutations in NOTCH1 cause aortic valve disease.
findings: []
- id: PMID:16107537
title: Direct regulation of intestinal fate by Notch.
findings: []
- id: PMID:16120638
title: Notch signaling coordinates the patterning of striatal compartments.
findings: []
- id: PMID:16145673
title: 'Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.'
findings: []
- id: PMID:16169548
title: Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.
findings: []
- id: PMID:16245338
title: Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.
findings: []
- id: PMID:16324690
title: BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.
findings: []
- id: PMID:16360140
title: Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.
findings: []
- id: PMID:16452096
title: Notch 1 inhibits photoreceptor production in the developing mammalian retina.
findings: []
- id: PMID:16607638
title: Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.
findings: []
- id: PMID:16618808
title: Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
findings: []
- id: PMID:17079689
title: Canonical notch signaling functions as a commitment switch in the epidermal lineage.
findings: []
- id: PMID:17210915
title: Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
findings: []
- id: PMID:17303760
title: Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.
findings: []
- id: PMID:17336907
title: Notch signaling is essential for ventricular chamber development.
findings: []
- id: PMID:17573339
title: Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
findings: []
- id: PMID:17658278
title: Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
findings: []
- id: PMID:17658279
title: Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
findings: []
- id: PMID:17685488
title: 'Monitoring Notch1 activity in development: evidence for a feedback regulatory loop.'
findings: []
- id: PMID:18299578
title: Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia
signaling pathways.
findings: []
- id: PMID:18430783
title: Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
findings: []
- id: PMID:18676613
title: The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.
findings: []
- id: PMID:18952909
title: Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis.
findings: []
- id: PMID:19154718
title: Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.
findings: []
- id: PMID:19245366
title: MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase
factor inhibiting hypoxia-inducible factor (FIH).
findings: []
- id: PMID:19251639
title: Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.
findings: []
- id: PMID:19620969
title: A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.
findings: []
- id: PMID:19695258
title: Notch1 represses osteogenic pathways in aortic valve cells.
findings: []
- id: PMID:20007915
title: Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
findings: []
- id: PMID:20547764
title: ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.
findings: []
- id: PMID:20890042
title: Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac
valve formation.
findings: []
- id: PMID:21102556
title: RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
findings: []
- id: PMID:21156799
title: Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation.
findings: []
- id: PMID:21191019
title: A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.
findings: []
- id: PMID:21266778
title: Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.
findings: []
- id: PMID:21311046
title: Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
findings: []
- id: PMID:21315255
title: Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal
networks.
findings: []
- id: PMID:21419176
title: The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate
each other's activities.
findings: []
- id: PMID:21493891
title: Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
findings: []
- id: PMID:21985982
title: Delta-like 1-Lysine613 regulates notch signaling.
findings: []
- id: PMID:22110751
title: Inhibitory role of Notch1 in calcific aortic valve disease.
findings: []
- id: PMID:22147266
title: Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose
knock-down inhibits myoblast differentiation.
findings: []
- id: PMID:22258620
title: Pten coordinates retinal neurogenesis by regulating Notch signalling.
findings: []
- id: PMID:23160044
title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
findings: []
- id: PMID:23284756
title: Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium.
findings: []
- id: PMID:23382219
title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
findings: []
- id: PMID:23583836
title: Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.
findings: []
- id: PMID:24667410
title: Notch4 reveals a novel mechanism regulating Notch signal transduction.
findings: []
- id: PMID:24715457
title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in
vertebrates.
findings: []
- id: PMID:25038826
title: Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
findings: []
- id: PMID:25535395
title: Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
findings: []
- id: PMID:26491108
title: Notch-Tnf signalling is required for development and homeostasis of arterial valves.
findings: []
- id: PMID:26635527
title: Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and
CREB Signaling.
findings: []
- id: PMID:27107132
title: Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.
findings: []
- id: PMID:27719760
title: BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development.
findings: []
- id: PMID:28089369
title: 'Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination
between Ligands.'
findings: []
- id: PMID:28498977
title: Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.
findings: []
- id: PMID:28561022
title: IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene
expression.
findings: []
- id: PMID:38891776
title: Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure.
findings: []
- id: PMID:7789282
title: Notch1 is required for the coordinate segmentation of somites.
findings: []
- id: PMID:8749394
title: Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
findings: []
- id: PMID:9102301
title: Conservation of the Notch signalling pathway in mammalian neurogenesis.
findings: []
- id: PMID:9111338
title: RBP-L, a transcription factor related to RBP-Jkappa.
findings: []
- id: PMID:9315665
title: Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.
findings: []
- id: Reactome:R-MMU-2023158
title: Glycosylation of Pre-Notch by Fringe
findings: []
- id: Reactome:R-MMU-2023179
title: Glucosylation of Pre-Notch by Poglut1
findings: []
- id: Reactome:R-MMU-2032750
title: Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum
findings: []
- id: Reactome:R-MMU-2053938
title: Dll4 binds Notch1
findings: []
- id: Reactome:R-MMU-2053963
title: Notch1 binds Jag1
findings: []
- id: Reactome:R-MMU-2066712
title: Dner binds Notch1
findings: []
- id: Reactome:R-MMU-2067638
title: Gamma secretase cleaves Dner:Notch1 complex
findings: []
- id: Reactome:R-MMU-2071906
title: Notch1 binds Dlk1
findings: []
- id: Reactome:R-MMU-2077477
title: Numb recruits Itch to Notch1
findings: []
- id: Reactome:R-MMU-2077479
title: Itch ubiquitinates Notch
findings: []
- id: Reactome:R-MMU-209285
title: The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD
into the cytoplasm
findings: []
- id: Reactome:R-MMU-4396387
title: mNOTCH1 coactivator complex bind promoters of Hey genes
findings: []
- id: Reactome:R-MMU-9667655
title: Nbea binds nicd1
findings: []
- id: Reactome:R-MMU-9793875
title: Dll3 binds Notch1
findings: []
- id: Reactome:R-MMU-9824206
title: Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm
findings: []
- id: Reactome:R-MMU-9824230
title: Hes7 binds the Lfng gene
findings: []
- id: Reactome:R-MMU-9824231
title: Rbpj:Nicd and Msgn1 bind the Lfng gene
findings: []
- id: Reactome:R-MMU-9824249
title: Expression of Notch1 in presomitic mesoderm
findings: []
- id: Reactome:R-MMU-9824278
title: Hes7 binds the Hes7 gene
findings: []
- id: Reactome:R-NUL-1986584
title: Fucosylation of Pre-Notch by POFUT1
findings: []
- id: Reactome:R-NUL-2063915
title: ADAM17 cleaves Notch1 at S2
findings: []
- id: Reactome:R-NUL-2064853
title: FBXW7 binds phosphorylated NICD1
findings: []
- id: Reactome:R-NUL-2064883
title: FBXW7 mediates ubiquitination of phosphorylated NICD1
findings: []
- id: Reactome:R-NUL-2065560
title: mNICD1 binds HIF1A
findings: []
- id: Reactome:R-NUL-2065902
title: Gamma secretase complex cleaves Cntn1-actived Notch1
findings: []
- id: Reactome:R-NUL-209162
title: Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD
findings: []
- id: Reactome:R-NUL-4396363
title: mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
findings: []