Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN). Major tumor suppressor that dephosphorylates phosphatidylinositol-3,4,5-trisphosphate (PIP3) to negatively regulate the PI3K/AKT signaling pathway. Also acts as a protein phosphatase on serine/threonine and tyrosine residues. Critical for cell cycle control, apoptosis regulation, and cell migration.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0042995 cell projection | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PTEN localizes to cell projections in neurons. Reason: Secondary or downstream function Supporting Evidence: UniProt:O08586 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus {ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000250|UniProtKB:P60484}. Cell projection, dendritic spine {ECO:0000269|PubMed:33428810}. file:mouse/Pten/Pten-deep-research-perplexity.md provider: perplexity |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PTEN antagonizes PI3K/AKT signaling by dephosphorylating PIP3. Reason: Secondary or downstream function Supporting Evidence: UniProt:O08586 Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Nuclear localization. Reason: Essential site of PTEN activity Supporting Evidence: UniProt:O08586 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus {ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PTEN negatively regulates PI3K/AKT signaling via lipid phosphatase activity. Reason: Secondary or downstream function Supporting Evidence: UniProt:O08586 Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival |
| GO:0005829 cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: Cytosolic localization. Reason: Essential site of PTEN activity Supporting Evidence: UniProt:O08586 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. |
| GO:0046856 phosphatidylinositol dephosphorylation | IBA GO_REF:0000033 | ACCEPT | Summary: Core lipid phosphatase function. Reason: Essential PTEN enzymatic activity Supporting Evidence: UniProt:O08586 Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate |
| GO:0004725 protein tyrosine phosphatase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Dual-specificity protein phosphatase activity. Reason: Essential PTEN enzymatic activity Supporting Evidence: UniProt:O08586 FUNCTION: Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Core PIP3 3-phosphatase activity. Reason: Essential PTEN enzymatic activity Supporting Evidence: UniProt:O08586 removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate file:mouse/Pten/Pten-deep-research-falcon.md Falcon synthesis supports PTEN as a phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase that antagonizes PI3K/AKT signaling. |
| GO:0048870 cell motility | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PTEN modulates cell migration and motility. Reason: Secondary or downstream function Supporting Evidence: UniProt:O08586 Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (By similarity). |
| GO:0004721 phosphoprotein phosphatase activity | IEA GO_REF:0000043 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0004722 protein serine/threonine phosphatase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0004725 protein tyrosine phosphatase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0006629 lipid metabolic process | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: lipid metabolic process Reason: Secondary or downstream function |
| GO:0006915 apoptotic process | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: apoptotic process Reason: Secondary or downstream function |
| GO:0007399 nervous system development | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: nervous system development Reason: Secondary or downstream function |
| GO:0008285 negative regulation of cell population proliferation | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: Negative regulation of proliferation is a downstream tumor-suppressor outcome of PTEN phosphatase activity. Reason: Secondary or downstream function |
| GO:0009966 regulation of signal transduction | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of signal transduction Reason: Secondary or downstream function |
| GO:0010604 positive regulation of macromolecule metabolic process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of macromolecule met... Reason: Secondary or downstream function |
| GO:0010648 negative regulation of cell communication | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of cell communicatio... Reason: Secondary or downstream function |
| GO:0010977 negative regulation of neuron projection development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of neuron projection... Reason: Secondary or downstream function |
| GO:0014069 postsynaptic density | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: postsynaptic density Reason: Secondary or downstream function |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0016605 PML body | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: PML body Reason: Secondary or downstream function |
| GO:0016787 hydrolase activity | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general |
| GO:0016791 phosphatase activity | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general |
| GO:0019899 enzyme binding | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general |
| GO:0023057 negative regulation of signaling | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of signaling Reason: Secondary or downstream function |
| GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity | IEA GO_REF:0000116 | KEEP AS NON CORE | Summary: inositol-1,3,4,5,6-pentakisphosphate 3-p... Reason: Secondary or downstream function |
| GO:0042995 cell projection | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: cell projection Reason: Secondary or downstream function |
| GO:0043197 dendritic spine | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: dendritic spine Reason: Secondary or downstream function |
| GO:0045595 regulation of cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of cell differentiation Reason: Secondary or downstream function |
| GO:0046856 phosphatidylinositol dephosphorylation | IEA GO_REF:0000002 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: inositol-1,3,4,5-tetrakisphosphate 3-pho... Reason: Secondary or downstream function |
| GO:0051726 regulation of cell cycle | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: regulation of cell cycle Reason: Secondary or downstream function |
| GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: phosphatidylinositol-3,4-bisphosphate 3-... Reason: Secondary or downstream function |
| GO:0060044 negative regulation of cardiac muscle cell proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of cardiac muscle ce... Reason: Secondary or downstream function |
| GO:0005515 protein binding | IPI PMID:16456542 PTEN tumor suppressor associates with NHERF proteins to atte... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:16456542 PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. |
| GO:0005515 protein binding | IPI PMID:17218262 Essential role for nuclear PTEN in maintaining chromosomal i... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:17218262 Essential role for nuclear PTEN in maintaining chromosomal integrity. |
| GO:0005515 protein binding | IPI PMID:18716620 The deubiquitinylation and localization of PTEN are regulate... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. |
| GO:0005515 protein binding | IPI PMID:23123091 Involvement of PTEN in TPA-mediated p53-activation in mouse ... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:23123091 Epub 2012 Oct 30. Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells. |
| GO:0005515 protein binding | IPI PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. |
| GO:0005886 plasma membrane | ISO GO_REF:0000119 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0006470 protein dephosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0006470 protein dephosphorylation | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0033137 negative regulation of peptidyl-serine phosphorylation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of peptidyl-serine p... Reason: Secondary or downstream function |
| GO:0097225 sperm midpiece | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: sperm midpiece Reason: Secondary or downstream function |
| GO:0097228 sperm principal piece | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: sperm principal piece Reason: Secondary or downstream function |
| GO:1901017 negative regulation of potassium ion transmembrane transporter activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of potassium ion tra... Reason: Secondary or downstream function |
| GO:2000272 negative regulation of signaling receptor activity | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of signaling recepto... Reason: Secondary or downstream function |
| GO:0001649 osteoblast differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: osteoblast differentiation Reason: Secondary or downstream function |
| GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phosphatidylinositol-3-phosphate phospha... Reason: Secondary or downstream function |
| GO:0004721 phosphoprotein phosphatase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0004722 protein serine/threonine phosphatase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0004725 protein tyrosine phosphatase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0005161 platelet-derived growth factor receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: platelet-derived growth factor receptor ... Reason: Secondary or downstream function |
| GO:0005634 nucleus | ISO GO_REF:0000119 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0005654 nucleoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0005737 cytoplasm | ISO GO_REF:0000119 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0005829 cytosol | ISO GO_REF:0000119 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0007056 spindle assembly involved in female meiosis | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: spindle assembly involved in female meio... Reason: Secondary or downstream function |
| GO:0007613 memory | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: memory Reason: Secondary or downstream function |
| GO:0008013 beta-catenin binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: beta-catenin binding Reason: Secondary or downstream function |
| GO:0008285 negative regulation of cell population proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Negative regulation of proliferation is a downstream tumor-suppressor outcome of PTEN phosphatase activity. Reason: Secondary or downstream function |
| GO:0008285 negative regulation of cell population proliferation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: Negative regulation of proliferation is a downstream tumor-suppressor outcome of PTEN phosphatase activity. Reason: Secondary or downstream function |
| GO:0009898 cytoplasmic side of plasma membrane | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cytoplasmic side of plasma membrane Reason: Secondary or downstream function |
| GO:0010628 positive regulation of gene expression | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of gene expression Reason: Secondary or downstream function |
| GO:0010666 positive regulation of cardiac muscle cell apoptotic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of cardiac muscle ce... Reason: Secondary or downstream function |
| GO:0010719 negative regulation of epithelial to mesenchymal transition | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of epithelial to mes... Reason: Secondary or downstream function |
| GO:0010977 negative regulation of neuron projection development | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of neuron projection... Reason: Secondary or downstream function |
| GO:0010997 anaphase-promoting complex binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: anaphase-promoting complex binding Reason: Secondary or downstream function |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | ISO GO_REF:0000096 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0016324 apical plasma membrane | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: apical plasma membrane Reason: Secondary or downstream function |
| GO:0019899 enzyme binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general |
| GO:0030165 PDZ domain binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: PDZ domain binding Reason: Secondary or downstream function |
| GO:0030165 PDZ domain binding | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: PDZ domain binding Reason: Secondary or downstream function |
| GO:0030336 negative regulation of cell migration | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of cell migration Reason: Secondary or downstream function |
| GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: inositol-1,3,4,5,6-pentakisphosphate 3-p... Reason: Secondary or downstream function |
| GO:0031175 neuron projection development | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: neuron projection development Reason: Secondary or downstream function |
| GO:0031647 regulation of protein stability | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: regulation of protein stability Reason: Secondary or downstream function |
| GO:0032755 positive regulation of interleukin-6 production | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of interleukin-6 pro... Reason: Secondary or downstream function |
| GO:0032760 positive regulation of tumor necrosis factor production | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of tumor necrosis fa... Reason: Secondary or downstream function |
| GO:0032869 cellular response to insulin stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cellular response to insulin stimulus Reason: Secondary or downstream function |
| GO:0035255 ionotropic glutamate receptor binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: ionotropic glutamate receptor binding Reason: Secondary or downstream function |
| GO:0042802 identical protein binding | ISO GO_REF:0000119 | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general |
| GO:0042995 cell projection | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cell projection Reason: Secondary or downstream function |
| GO:0043065 positive regulation of apoptotic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of apoptotic process Reason: Secondary or downstream function |
| GO:0043066 negative regulation of apoptotic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: Apoptosis regulation is a downstream PI3K/AKT pathway outcome of PTEN phosphatase activity. Reason: Secondary or downstream function |
| GO:0043197 dendritic spine | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: dendritic spine Reason: Secondary or downstream function |
| GO:0044320 cellular response to leptin stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cellular response to leptin stimulus Reason: Secondary or downstream function |
| GO:0045211 postsynaptic membrane | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic membrane Reason: Secondary or downstream function |
| GO:0045666 positive regulation of neuron differentiation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: positive regulation of neuron differenti... Reason: Secondary or downstream function |
| GO:0045668 negative regulation of osteoblast differentiation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of osteoblast differ... Reason: Secondary or downstream function |
| GO:0045786 negative regulation of cell cycle | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cell cycle Reason: Secondary or downstream function |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of transcription by ... Reason: Secondary or downstream function |
| GO:0046856 phosphatidylinositol dephosphorylation | ISO GO_REF:0000096 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0046856 phosphatidylinositol dephosphorylation | ISO GO_REF:0000119 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0048008 platelet-derived growth factor receptor signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: platelet-derived growth factor receptor ... Reason: Secondary or downstream function |
| GO:0050765 negative regulation of phagocytosis | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of phagocytosis Reason: Secondary or downstream function |
| GO:0050821 protein stabilization | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: protein stabilization Reason: Secondary or downstream function |
| GO:0051548 negative regulation of keratinocyte migration | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of keratinocyte migr... Reason: Secondary or downstream function |
| GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: inositol-1,3,4,5-tetrakisphosphate 3-pho... Reason: Secondary or downstream function |
| GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phosphatidylinositol-3,4-bisphosphate 3-... Reason: Secondary or downstream function |
| GO:0051895 negative regulation of focal adhesion assembly | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of focal adhesion as... Reason: Secondary or downstream function |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | ISO GO_REF:0000119 | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role |
| GO:0052866 phosphatidylinositol phosphate phosphatase activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: phosphatidylinositol phosphate phosphata... Reason: Secondary or downstream function |
| GO:0060044 negative regulation of cardiac muscle cell proliferation | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of cardiac muscle ce... Reason: Secondary or downstream function |
| GO:0060292 long-term synaptic depression | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: long-term synaptic depression Reason: Secondary or downstream function |
| GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: regulation of Fc receptor mediated stimu... Reason: Secondary or downstream function |
| GO:0071257 cellular response to electrical stimulus | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: cellular response to electrical stimulus Reason: Secondary or downstream function |
| GO:0071361 cellular response to ethanol | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cellular response to ethanol Reason: Secondary or downstream function |
| GO:0071545 inositol phosphate catabolic process | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: inositol phosphate catabolic process Reason: Secondary or downstream function |
| GO:0099524 postsynaptic cytosol | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: postsynaptic cytosol Reason: Secondary or downstream function |
| GO:0140678 molecular function inhibitor activity | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: molecular function inhibitor activity Reason: Secondary or downstream function |
| GO:1900425 negative regulation of defense response to bacterium | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of defense response ... Reason: Secondary or downstream function |
| GO:1902533 positive regulation of intracellular signal transduction | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of intracellular sig... Reason: Secondary or downstream function |
| GO:1902807 negative regulation of cell cycle G1/S phase transition | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of cell cycle G1/S p... Reason: Secondary or downstream function |
| GO:1903690 negative regulation of wound healing, spreading of epidermal cells | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of wound healing, sp... Reason: Secondary or downstream function |
| GO:1903860 negative regulation of dendrite extension | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: negative regulation of dendrite extensio... Reason: Secondary or downstream function |
| GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of vascular associat... Reason: Secondary or downstream function |
| GO:1990314 cellular response to insulin-like growth factor stimulus | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: cellular response to insulin-like growth... Reason: Secondary or downstream function |
| GO:1990782 protein tyrosine kinase binding | ISO GO_REF:0000096 | KEEP AS NON CORE | Summary: protein tyrosine kinase binding Reason: Secondary or downstream function |
| GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: positive regulation of ubiquitin-depende... Reason: Secondary or downstream function |
| GO:2000134 negative regulation of G1/S transition of mitotic cell cycle | ISO GO_REF:0000119 | KEEP AS NON CORE | Summary: negative regulation of G1/S transition o... Reason: Secondary or downstream function |
| GO:0060766 negative regulation of androgen receptor signaling pathway | IMP PMID:29057879 Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates ... | KEEP AS NON CORE | Summary: negative regulation of androgen receptor... Reason: Secondary or downstream function Supporting Evidence: PMID:29057879 Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. |
| GO:1904262 negative regulation of TORC1 signaling | IMP PMID:29057879 Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates ... | KEEP AS NON CORE | Summary: negative regulation of TORC1 signaling Reason: Secondary or downstream function Supporting Evidence: PMID:29057879 Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:20940307 Regulation of PTEN stability and activity by Plk3. | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:20940307 2010 Oct 12. Regulation of PTEN stability and activity by Plk3. |
| GO:0007270 neuron-neuron synaptic transmission | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: neuron-neuron synaptic transmission Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0032286 central nervous system myelin maintenance | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: central nervous system myelin maintenanc... Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0043005 neuron projection | IDA PMID:21664258 Reelin deficiency causes specific defects in the molecular c... | KEEP AS NON CORE | Summary: neuron projection Reason: Secondary or downstream function Supporting Evidence: PMID:21664258 Epub 2011 Jun 2. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. |
| GO:0060074 synapse maturation | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: synapse maturation Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0060291 long-term synaptic potentiation | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: long-term synaptic potentiation Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0060997 dendritic spine morphogenesis | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: dendritic spine morphogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0090394 negative regulation of excitatory postsynaptic potential | IMP PMID:21411674 Pten knockdown in vivo increases excitatory drive onto denta... | KEEP AS NON CORE | Summary: negative regulation of excitatory postsy... Reason: Secondary or downstream function Supporting Evidence: PMID:21411674 Pten knockdown in vivo increases excitatory drive onto dentate granule cells. |
| GO:0097105 presynaptic membrane assembly | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: presynaptic membrane assembly Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0097107 postsynaptic density assembly | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: postsynaptic density assembly Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:1990757 ubiquitin ligase activator activity | IMP PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive comple... | KEEP AS NON CORE | Summary: ubiquitin ligase activator activity Reason: Secondary or downstream function Supporting Evidence: PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. |
| GO:2000463 positive regulation of excitatory postsynaptic potential | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: positive regulation of excitatory postsy... Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:2000808 negative regulation of synaptic vesicle clustering | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: negative regulation of synaptic vesicle ... Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: inositol-1,3,4,5,6-pentakisphosphate 3-p... Reason: Secondary or downstream function |
| GO:0006915 apoptotic process | IGI PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endomet... | KEEP AS NON CORE | Summary: apoptotic process Reason: Secondary or downstream function Supporting Evidence: PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. |
| GO:0010467 gene expression | IGI PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endomet... | KEEP AS NON CORE | Summary: gene expression Reason: Secondary or downstream function Supporting Evidence: PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. |
| GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation | IGI PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endomet... | KEEP AS NON CORE | Summary: negative regulation of protein kinase ac... Reason: Secondary or downstream function Supporting Evidence: PMID:20418913 The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:19147652 MicroRNA expression in response to murine myocardial infarct... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:19147652 MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. |
| GO:2000773 negative regulation of cellular senescence | IMP PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive comple... | KEEP AS NON CORE | Summary: negative regulation of cellular senescen... Reason: Secondary or downstream function Supporting Evidence: PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | ISO PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. |
| GO:1990381 ubiquitin-specific protease binding | ISO PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses... | KEEP AS NON CORE | Summary: ubiquitin-specific protease binding Reason: Secondary or downstream function Supporting Evidence: PMID:26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. |
| GO:0048681 negative regulation of axon regeneration | IMP PMID:26203138 Gene-Silencing Screen for Mammalian Axon Regeneration Identi... | KEEP AS NON CORE | Summary: negative regulation of axon regeneration Reason: Secondary or downstream function Supporting Evidence: PMID:26203138 Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. |
| GO:0060044 negative regulation of cardiac muscle cell proliferation | IGI PMID:23575307 mir-17-92 cluster is required for and sufficient to induce c... | KEEP AS NON CORE | Summary: negative regulation of cardiac muscle ce... Reason: Secondary or downstream function Supporting Evidence: PMID:23575307 2013 Apr 10. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. |
| GO:0032228 regulation of synaptic transmission, GABAergic | IMP PMID:24875179 PTEN degradation after ischemic stroke: a double-edged sword... | KEEP AS NON CORE | Summary: regulation of synaptic transmission, GAB... Reason: Secondary or downstream function Supporting Evidence: PMID:24875179 Epub 2014 May 27. PTEN degradation after ischemic stroke: a double-edged sword. |
| GO:0036294 cellular response to decreased oxygen levels | IDA PMID:24875179 PTEN degradation after ischemic stroke: a double-edged sword... | KEEP AS NON CORE | Summary: cellular response to decreased oxygen le... Reason: Secondary or downstream function Supporting Evidence: PMID:24875179 Epub 2014 May 27. PTEN degradation after ischemic stroke: a double-edged sword. |
| GO:0071456 cellular response to hypoxia | IDA PMID:24875179 PTEN degradation after ischemic stroke: a double-edged sword... | KEEP AS NON CORE | Summary: cellular response to hypoxia Reason: Secondary or downstream function Supporting Evidence: PMID:24875179 Epub 2014 May 27. PTEN degradation after ischemic stroke: a double-edged sword. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:25512490 PTEN signaling through RAF1 proto-oncogene serine/threonine ... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:25512490 PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IMP PMID:25512490 PTEN signaling through RAF1 proto-oncogene serine/threonine ... | KEEP AS NON CORE | Summary: positive regulation of ERK1 and ERK2 cas... Reason: Secondary or downstream function Supporting Evidence: PMID:25512490 PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. |
| GO:0048679 regulation of axon regeneration | IGI PMID:24733831 B-RAF kinase drives developmental axon growth and promotes a... | KEEP AS NON CORE | Summary: regulation of axon regeneration Reason: Secondary or downstream function Supporting Evidence: PMID:24733831 B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. |
| GO:0005515 protein binding | IPI PMID:20448149 Dlg1-PTEN interaction regulates myelin thickness to prevent ... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:20448149 May 6. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. |
| GO:0005515 protein binding | IPI PMID:18332125 PTEN nuclear localization is regulated by oxidative stress a... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:18332125 Mar 10. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. |
| GO:2001235 positive regulation of apoptotic signaling pathway | IMP PMID:9778245 Negative regulation of PKB/Akt-dependent cell survival by th... | KEEP AS NON CORE | Summary: positive regulation of apoptotic signali... Reason: Secondary or downstream function Supporting Evidence: PMID:9778245 Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. |
| GO:0060341 regulation of cellular localization | IMP PMID:21266327 Rictor/mTORC2 is essential for maintaining a balance between... | KEEP AS NON CORE | Summary: regulation of cellular localization Reason: Secondary or downstream function Supporting Evidence: PMID:21266327 Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. |
| GO:0007416 synapse assembly | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: synapse assembly Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0033555 multicellular organismal response to stress | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: multicellular organismal response to str... Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0048853 forebrain morphogenesis | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: forebrain morphogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0050771 negative regulation of axonogenesis | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: negative regulation of axonogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0031642 negative regulation of myelination | IMP PMID:20448149 Dlg1-PTEN interaction regulates myelin thickness to prevent ... | KEEP AS NON CORE | Summary: negative regulation of myelination Reason: Secondary or downstream function Supporting Evidence: PMID:20448149 May 6. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:20448149 Dlg1-PTEN interaction regulates myelin thickness to prevent ... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:20448149 May 6. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. |
| GO:0019901 protein kinase binding | IPI PMID:20940307 Regulation of PTEN stability and activity by Plk3. | KEEP AS NON CORE | Summary: protein kinase binding Reason: Secondary or downstream function Supporting Evidence: PMID:20940307 2010 Oct 12. Regulation of PTEN stability and activity by Plk3. |
| GO:0007611 learning or memory | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: learning or memory Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0007626 locomotory behavior | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: locomotory behavior Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0021542 dentate gyrus development | IMP PMID:17706614 A seizure-prone phenotype is associated with altered free-ru... | KEEP AS NON CORE | Summary: dentate gyrus development Reason: Secondary or downstream function Supporting Evidence: PMID:17706614 2007 Jul 20. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. |
| GO:0021955 central nervous system neuron axonogenesis | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: central nervous system neuron axonogenes... Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0030534 adult behavior | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: adult behavior Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0032535 regulation of cellular component size | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: regulation of cellular component size Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:0035176 social behavior | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: social behavior Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0035176 social behavior | IMP PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooper... | KEEP AS NON CORE | Summary: social behavior Reason: Secondary or downstream function Supporting Evidence: PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. |
| GO:0042711 maternal behavior | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: maternal behavior Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0045475 locomotor rhythm | IMP PMID:17706614 A seizure-prone phenotype is associated with altered free-ru... | KEEP AS NON CORE | Summary: locomotor rhythm Reason: Secondary or downstream function Supporting Evidence: PMID:17706614 2007 Jul 20. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. |
| GO:0045792 negative regulation of cell size | IMP PMID:21411674 Pten knockdown in vivo increases excitatory drive onto denta... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:21411674 Pten knockdown in vivo increases excitatory drive onto dentate granule cells. |
| GO:0046621 negative regulation of organ growth | IMP PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooper... | KEEP AS NON CORE | Summary: negative regulation of organ growth Reason: Secondary or downstream function Supporting Evidence: PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. |
| GO:0048854 brain morphogenesis | IMP PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooper... | KEEP AS NON CORE | Summary: brain morphogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0060024 rhythmic synaptic transmission | IMP PMID:17706614 A seizure-prone phenotype is associated with altered free-ru... | KEEP AS NON CORE | Summary: rhythmic synaptic transmission Reason: Secondary or downstream function Supporting Evidence: PMID:17706614 2007 Jul 20. A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. |
| GO:0060134 prepulse inhibition | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: prepulse inhibition Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0060134 prepulse inhibition | IMP PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooper... | KEEP AS NON CORE | Summary: prepulse inhibition Reason: Secondary or downstream function Supporting Evidence: PMID:19208814 Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. |
| GO:0060179 male mating behavior | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: male mating behavior Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0060997 dendritic spine morphogenesis | IMP PMID:21411674 Pten knockdown in vivo increases excitatory drive onto denta... | KEEP AS NON CORE | Summary: dendritic spine morphogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:21411674 Pten knockdown in vivo increases excitatory drive onto dentate granule cells. |
| GO:0061002 negative regulation of dendritic spine morphogenesis | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: negative regulation of dendritic spine m... Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0090071 negative regulation of ribosome biogenesis | IMP PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 def... | KEEP AS NON CORE | Summary: negative regulation of ribosome biogenes... Reason: Secondary or downstream function Supporting Evidence: PMID:18082964 Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. |
| GO:2000808 negative regulation of synaptic vesicle clustering | IMP PMID:16675393 Pten regulates neuronal arborization and social interaction ... | KEEP AS NON CORE | Summary: negative regulation of synaptic vesicle ... Reason: Secondary or downstream function Supporting Evidence: PMID:16675393 Pten regulates neuronal arborization and social interaction in mice. |
| GO:0043005 neuron projection | IMP PMID:21664258 Reelin deficiency causes specific defects in the molecular c... | KEEP AS NON CORE | Summary: neuron projection Reason: Secondary or downstream function Supporting Evidence: PMID:21664258 Epub 2011 Jun 2. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. |
| GO:0035749 myelin sheath adaxonal region | IDA PMID:20237282 Pals1 is a major regulator of the epithelial-like polarizati... | UNDECIDED | Summary: Cannot be adjudicated here: PMID:20237282 is cached abstract-only. Prior observation, not a verdict: PMID:20237282 supports Pals1-dependent Schwann-cell polarity and myelin extension, not direct PTEN localization to the myelin sheath adaxonal region. Reason: PMID:20237282 is cached abstract-only, so the curator's experimental evidence cannot be inspected here; per CLAUDE.md an experimental annotation is not overruled on that basis. Recorded observation, not a verdict: Cached evidence is for Pals1/myelin polarity and does not support this Pten annotation. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive comple... | KEEP AS NON CORE | Summary: positive regulation of cell population p... Reason: Secondary or downstream function Supporting Evidence: PMID:21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. |
| GO:0043220 Schmidt-Lanterman incisure | IDA PMID:20237282 Pals1 is a major regulator of the epithelial-like polarizati... | UNDECIDED | Summary: Cannot be adjudicated here: PMID:20237282 is cached abstract-only. Prior observation, not a verdict: PMID:20237282 supports Pals1-dependent Schwann-cell polarity and myelin extension, not direct PTEN localization to Schmidt-Lanterman incisures. Reason: PMID:20237282 is cached abstract-only, so the curator's experimental evidence cannot be inspected here; per CLAUDE.md an experimental annotation is not overruled on that basis. Recorded observation, not a verdict: Cached evidence is for Pals1/myelin polarity and does not support this Pten annotation. |
| GO:0005515 protein binding | IPI PMID:18190691 Na+/H+ exchanger regulatory factor 1 inhibits platelet-deriv... | MARK AS OVER ANNOTATED | Summary: Non-specific term Reason: Term is too general Supporting Evidence: PMID:18190691 Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. |
| GO:0010975 regulation of neuron projection development | IMP PMID:19778506 DISC1 regulates new neuron development in the adult brain vi... | KEEP AS NON CORE | Summary: regulation of neuron projection developm... Reason: Secondary or downstream function Supporting Evidence: PMID:19778506 DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. |
| GO:0005634 nucleus | IDA PMID:18332125 PTEN nuclear localization is regulated by oxidative stress a... | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity Supporting Evidence: PMID:18332125 Mar 10. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. |
| GO:0051726 regulation of cell cycle | IGI PMID:18332125 PTEN nuclear localization is regulated by oxidative stress a... | KEEP AS NON CORE | Summary: regulation of cell cycle Reason: Secondary or downstream function Supporting Evidence: PMID:18332125 Mar 10. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. |
| GO:0002902 regulation of B cell apoptotic process | IMP PMID:9990064 Mutation of Pten/Mmac1 in mice causes neoplasia in multiple ... | KEEP AS NON CORE | Summary: regulation of B cell apoptotic process Reason: Secondary or downstream function Supporting Evidence: PMID:9990064 Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. |
| GO:0033032 regulation of myeloid cell apoptotic process | IMP PMID:9990064 Mutation of Pten/Mmac1 in mice causes neoplasia in multiple ... | KEEP AS NON CORE | Summary: regulation of myeloid cell apoptotic pro... Reason: Secondary or downstream function Supporting Evidence: PMID:9990064 Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. |
| GO:0005634 nucleus | IDA PMID:14522255 Prostate-specific deletion of the murine Pten tumor suppress... | UNDECIDED | Summary: PMID:14522255 supports Pten prostate tumor suppression in the cached abstract, but does not provide direct PTEN nuclear localization evidence. Reason: Full-text localization evidence would be needed before accepting this evidence-specific nucleus annotation. |
| GO:0005737 cytoplasm | IDA PMID:14522255 Prostate-specific deletion of the murine Pten tumor suppress... | UNDECIDED | Summary: PMID:14522255 supports Pten prostate tumor suppression in the cached abstract, but does not provide direct PTEN cytoplasmic localization evidence. Reason: Full-text localization evidence would be needed before accepting this evidence-specific cytoplasm annotation. |
| GO:0050680 negative regulation of epithelial cell proliferation | IMP PMID:15994948 Targeted biallelic inactivation of Pten in the mouse prostat... | KEEP AS NON CORE | Summary: negative regulation of epithelial cell p... Reason: Secondary or downstream function Supporting Evidence: PMID:15994948 Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. |
| GO:0060736 prostate gland growth | IMP PMID:15994948 Targeted biallelic inactivation of Pten in the mouse prostat... | KEEP AS NON CORE | Summary: prostate gland growth Reason: Secondary or downstream function Supporting Evidence: PMID:15994948 Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. |
| GO:0005634 nucleus | IDA PMID:18562292 The ubiquitin ligase Nedd4-1 is dispensable for the regulati... | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity Supporting Evidence: PMID:18562292 The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. |
| GO:0005737 cytoplasm | IDA PMID:18562292 The ubiquitin ligase Nedd4-1 is dispensable for the regulati... | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity Supporting Evidence: PMID:18562292 The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. |
| GO:0008285 negative regulation of cell population proliferation | IMP PMID:16027169 Feedback inhibition of Akt signaling limits the growth of tu... | KEEP AS NON CORE | Summary: Negative regulation of proliferation is supported as a downstream tumor-suppressor outcome of PTEN signaling, but not as the core enzymatic function. Reason: Secondary or downstream function Supporting Evidence: PMID:16027169 Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. |
| GO:0008285 negative regulation of cell population proliferation | IGI PMID:16027168 Genetic analysis of Pten and Tsc2 functional interactions in... | KEEP AS NON CORE | Summary: Negative regulation of proliferation is supported as a downstream tumor-suppressor outcome of PTEN signaling, but not as the core enzymatic function. Reason: Secondary or downstream function Supporting Evidence: PMID:16027168 Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. |
| GO:0001525 angiogenesis | IMP PMID:16107612 The PTEN/PI3K pathway governs normal vascular development an... | KEEP AS NON CORE | Summary: angiogenesis Reason: Secondary or downstream function Supporting Evidence: PMID:16107612 The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. |
| GO:0043542 endothelial cell migration | IMP PMID:16107612 The PTEN/PI3K pathway governs normal vascular development an... | KEEP AS NON CORE | Summary: endothelial cell migration Reason: Secondary or downstream function Supporting Evidence: PMID:16107612 The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. |
| GO:0048738 cardiac muscle tissue development | IMP PMID:16107612 The PTEN/PI3K pathway governs normal vascular development an... | KEEP AS NON CORE | Summary: cardiac muscle tissue development Reason: Secondary or downstream function Supporting Evidence: PMID:16107612 The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. |
| GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: phosphatidylinositol-3,4-bisphosphate 3-... Reason: Secondary or downstream function |
| GO:0051895 negative regulation of focal adhesion assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of focal adhesion as... Reason: Secondary or downstream function |
| GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:10339565 PTEN modulates cell cycle progression and cell survival by r... | ACCEPT | Summary: Core PI3K pathway regulation Reason: Essential PTEN signaling role Supporting Evidence: PMID:10339565 PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. |
| GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: phosphatidylinositol-3-phosphate phospha... Reason: Secondary or downstream function |
| GO:0004722 protein serine/threonine phosphatase activity | ISS GO_REF:0000024 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0004725 protein tyrosine phosphatase activity | ISS GO_REF:0000024 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0005737 cytoplasm | ISS GO_REF:0000024 | ACCEPT | Summary: Cellular localization Reason: Essential site of PTEN activity |
| GO:0006470 protein dephosphorylation | ISS GO_REF:0000024 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0008285 negative regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Negative regulation of proliferation is a downstream outcome of PTEN phosphatase activity. Reason: Secondary or downstream function |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | ISS GO_REF:0000024 | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity |
| GO:0030165 PDZ domain binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: PDZ domain binding Reason: Secondary or downstream function |
| GO:0030336 negative regulation of cell migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of cell migration Reason: Secondary or downstream function |
| GO:0031647 regulation of protein stability | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of protein stability Reason: Secondary or downstream function |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:10339565 PTEN modulates cell cycle progression and cell survival by r... | KEEP AS NON CORE | Summary: Apoptosis regulation is a downstream PI3K/AKT pathway outcome of PTEN phosphatase activity. Reason: Secondary or downstream function Supporting Evidence: PMID:10339565 PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. |
| GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: inositol-1,3,4,5-tetrakisphosphate 3-pho... Reason: Secondary or downstream function |
| GO:0007507 heart development | IMP PMID:15755804 Analysis of mouse embryonic patterning and morphogenesis by ... | KEEP AS NON CORE | Summary: heart development Reason: Secondary or downstream function Supporting Evidence: PMID:15755804 Analysis of mouse embryonic patterning and morphogenesis by forward genetics. |
| GO:0007417 central nervous system development | IMP PMID:12091320 PTEN is essential for cell migration but not for fate determ... | KEEP AS NON CORE | Summary: central nervous system development Reason: Secondary or downstream function Supporting Evidence: PMID:12091320 PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. |
| GO:0016477 cell migration | IMP PMID:12091320 PTEN is essential for cell migration but not for fate determ... | KEEP AS NON CORE | Summary: cell migration Reason: Secondary or downstream function Supporting Evidence: PMID:12091320 PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. |
| GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | IDA PMID:9778245 Negative regulation of PKB/Akt-dependent cell survival by th... | ACCEPT | Summary: Core phosphatase function Reason: Essential PTEN enzymatic activity Supporting Evidence: PMID:9778245 Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. |
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